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<button class="button is-small is-link">Go</button> </div> </div> </form> </div> </div> <ol class="breathe-horizontal" start="1"> <li class="arxiv-result"> <div class="is-marginless"> <p class="list-title is-inline-block"><a href="https://arxiv.org/abs/2410.21256">arXiv:2410.21256</a> <span> [<a href="https://arxiv.org/pdf/2410.21256">pdf</a>, <a href="https://arxiv.org/format/2410.21256">other</a>] </span> </p> <div class="tags is-inline-block"> <span class="tag is-small is-link tooltip is-tooltip-top" data-tooltip="Artificial Intelligence">cs.AI</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Computer Vision and Pattern Recognition">cs.CV</span> <span class="tag is-small is-grey tooltip is-tooltip-top" data-tooltip="Image and Video Processing">eess.IV</span> </div> </div> <p class="title is-5 mathjax"> Multi-modal AI for comprehensive breast cancer prognostication </p> <p class="authors"> <span class="search-hit">Authors:</span> <a href="/search/cs?searchtype=author&query=Witowski%2C+J">Jan Witowski</a>, <a href="/search/cs?searchtype=author&query=Zeng%2C+K">Ken Zeng</a>, <a href="/search/cs?searchtype=author&query=Cappadona%2C+J">Joseph Cappadona</a>, <a href="/search/cs?searchtype=author&query=Elayoubi%2C+J">Jailan Elayoubi</a>, <a href="/search/cs?searchtype=author&query=Chiru%2C+E+D">Elena Diana Chiru</a>, <a href="/search/cs?searchtype=author&query=Chan%2C+N">Nancy Chan</a>, <a href="/search/cs?searchtype=author&query=Kang%2C+Y">Young-Joon Kang</a>, <a href="/search/cs?searchtype=author&query=Howard%2C+F">Frederick Howard</a>, <a href="/search/cs?searchtype=author&query=Ostrovnaya%2C+I">Irina Ostrovnaya</a>, <a href="/search/cs?searchtype=author&query=Fernandez-Granda%2C+C">Carlos Fernandez-Granda</a>, <a href="/search/cs?searchtype=author&query=Schnabel%2C+F">Freya Schnabel</a>, <a href="/search/cs?searchtype=author&query=Ozerdem%2C+U">Ugur Ozerdem</a>, <a href="/search/cs?searchtype=author&query=Liu%2C+K">Kangning Liu</a>, <a href="/search/cs?searchtype=author&query=Steinsnyder%2C+Z">Zoe Steinsnyder</a>, <a href="/search/cs?searchtype=author&query=Thakore%2C+N">Nitya Thakore</a>, <a href="/search/cs?searchtype=author&query=Sadic%2C+M">Mohammad Sadic</a>, <a href="/search/cs?searchtype=author&query=Yeung%2C+F">Frank Yeung</a>, <a href="/search/cs?searchtype=author&query=Liu%2C+E">Elisa Liu</a>, <a href="/search/cs?searchtype=author&query=Hill%2C+T">Theodore Hill</a>, <a href="/search/cs?searchtype=author&query=Swett%2C+B">Benjamin Swett</a>, <a href="/search/cs?searchtype=author&query=Rigau%2C+D">Danielle Rigau</a>, <a href="/search/cs?searchtype=author&query=Clayburn%2C+A">Andrew Clayburn</a>, <a href="/search/cs?searchtype=author&query=Speirs%2C+V">Valerie Speirs</a>, <a href="/search/cs?searchtype=author&query=Vetter%2C+M">Marcus Vetter</a>, <a href="/search/cs?searchtype=author&query=Sojak%2C+L">Lina Sojak</a> , et al. (26 additional authors not shown) </p> <p class="abstract mathjax"> <span class="has-text-black-bis has-text-weight-semibold">Abstract</span>: <span class="abstract-short has-text-grey-dark mathjax" id="2410.21256v1-abstract-short" style="display: inline;"> Treatment selection in breast cancer is guided by molecular subtypes and clinical characteristics. Recurrence risk assessment plays a crucial role in personalizing treatment. Current methods, including genomic assays, have limited accuracy and clinical utility, leading to suboptimal decisions for many patients. We developed a test for breast cancer patient stratification based on digital pathology… <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2410.21256v1-abstract-full').style.display = 'inline'; document.getElementById('2410.21256v1-abstract-short').style.display = 'none';">▽ More</a> </span> <span class="abstract-full has-text-grey-dark mathjax" id="2410.21256v1-abstract-full" style="display: none;"> Treatment selection in breast cancer is guided by molecular subtypes and clinical characteristics. Recurrence risk assessment plays a crucial role in personalizing treatment. Current methods, including genomic assays, have limited accuracy and clinical utility, leading to suboptimal decisions for many patients. We developed a test for breast cancer patient stratification based on digital pathology and clinical characteristics using novel AI methods. Specifically, we utilized a vision transformer-based pan-cancer foundation model trained with self-supervised learning to extract features from digitized H&E-stained slides. These features were integrated with clinical data to form a multi-modal AI test predicting cancer recurrence and death. The test was developed and evaluated using data from a total of 8,161 breast cancer patients across 15 cohorts originating from seven countries. Of these, 3,502 patients from five cohorts were used exclusively for evaluation, while the remaining patients were used for training. Our test accurately predicted our primary endpoint, disease-free interval, in the five external cohorts (C-index: 0.71 [0.68-0.75], HR: 3.63 [3.02-4.37, p<0.01]). In a direct comparison (N=858), the AI test was more accurate than Oncotype DX, the standard-of-care 21-gene assay, with a C-index of 0.67 [0.61-0.74] versus 0.61 [0.49-0.73], respectively. Additionally, the AI test added independent information to Oncotype DX in a multivariate analysis (HR: 3.11 [1.91-5.09, p<0.01)]). The test demonstrated robust accuracy across all major breast cancer subtypes, including TNBC (C-index: 0.71 [0.62-0.81], HR: 3.81 [2.35-6.17, p=0.02]), where no diagnostic tools are currently recommended by clinical guidelines. These results suggest that our AI test can improve accuracy, extend applicability to a wider range of patients, and enhance access to treatment selection tools. <a class="is-size-7" style="white-space: nowrap;" onclick="document.getElementById('2410.21256v1-abstract-full').style.display = 'none'; document.getElementById('2410.21256v1-abstract-short').style.display = 'inline';">△ Less</a> </span> </p> <p class="is-size-7"><span class="has-text-black-bis has-text-weight-semibold">Submitted</span> 28 October, 2024; <span class="has-text-black-bis has-text-weight-semibold">originally announced</span> October 2024. </p> </li> </ol> <div class="is-hidden-tablet">  <span class="help" style="display: inline-block;"><a href="https://github.com/arXiv/arxiv-search/releases">Search v0.5.6 released 2020-02-24</a>  </span> </div> </div> </main> <footer> <div class="columns is-desktop" role="navigation" aria-label="Secondary">  <div class="column"> <div class="columns"> <div class="column"> <ul 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