Unraveling the complexities of adolescent depression: A call for action

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article </span> </div> </div> <div class="sectioncontent cl" id="cimg5div" style="display:none;"> <span id="citation_html">Zhang Y, Hei MY, Wang MZ, Zhang JG, Wang S. Unraveling the complexities of adolescent depression: A call for action. <em>World J Psychiatry</em> 2024; 14(11): 1772-1778 [PMID: <a href='http://www.ncbi.nlm.nih.gov/pubmed/39564178' target='_blank'>39564178</a> DOI: <a href='https://dx.doi.org/10.5498/wjp.v14.i11.1772' target='_blank'>10.5498/wjp.v14.i11.1772</a>]</span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg6');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg6" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Corresponding Author of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg6div" style="display:none;"> <span>Shu Wang, MD, Neurosurgeon, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing 100070, China. <email>wangshu.cn@outlook.com</email></span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg10');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg10" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Research Domain of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg10div" style="display:none;"> <span>Psychiatry</span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg11');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg11" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Article-Type of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg11div" style="display:none;"> <span>Letter to the Editor</span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg12');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg12" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Open-Access Policy of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg12div" style="display:none;"> <span>This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <a href="http://creativecommons.org/licenses/by-nc/4.0/" target="_blank">http://creativecommons.org/licenses/by-nc/4.0/</a></span> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl" onclick="ShowDetail('cimg15');"> <div class="sectionimg fl"> <img style="border:0;" alt="" id="cimg15" src="https://www.f6publishing.com/contents/images/collapsed_yes.gif" /> </div> <div class="sectiontext fl"> <span> Times Cited Counts in Google of This Article </span> </div> </div> <div class="sectioncontent cl" id="cimg15div" style="display:none;"> <ul> <li><a href="http://www.google.com/search?as_q=Unraveling the complexities of adolescent depression: A call for action" target="_blank">Unraveling the complexities of adolescent depression: A call for action</a></li> </ul> </div> </div> <div class="left-collapse cl"> <div class="sectiontitle cl"> <div class="sectiontext fl"> <span> Number of Hits and Downloads for This Article </span> </div> </div> <div class="sectioncontent 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class="infotitle"> Publisher of This Article </div> <div class="infocontent"> Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA </div> <br /> </div> </div> </div> <div class="infopart fr"> <link rel="stylesheet" href="/DXR.axd?r=1_74,1_68,1_69,1_70,1_73,1_210,1_207-2NNPn" /><link rel="stylesheet" href="/DXR.axd?r=1_209,1_206,1_254,1_253,1_84-2NNPn" /> <script id="dxis_1324860310" 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Author(s) 2024.</b><span> Published by Baishideng Publishing Group Inc. All rights reserved.</span> </div> <div id="dpjournal"> <span>World J Psychiatry. </span><span>Nov 19, 2024; </span><span>14(11): 1772-1778</span><br /> <span>Published online Nov 19, 2024. doi: <a href="http://dx.doi.org/10.5498/wjp.v14.i11.1772" target="_self">10.5498/wjp.v14.i11.1772</a></span> </div> <div id="dptitle"> Unraveling the complexities of adolescent depression: A call for action </div> <div id="dpauthors"> <a href="javascript:void(0);" id="thisauthor699677" class="author-name-link" data-f-name="Yuan" data-l-name="Zhang" data-name="Yuan Zhang" target="_self">Yuan Zhang</a>, <a href="javascript:void(0);" id="thisauthor699678" class="author-name-link" data-f-name="Ming-Yan" data-l-name="Hei" data-name="Ming-Yan Hei" target="_self">Ming-Yan Hei</a>, <a href="javascript:void(0);" id="thisauthor699679" class="author-name-link" data-f-name="Min-Zhong" data-l-name="Wang" data-name="Min-Zhong Wang" target="_self">Min-Zhong Wang</a>, <a href="javascript:void(0);" id="thisauthor699680" class="author-name-link" data-f-name="Jian-Guo" data-l-name="Zhang" data-name="Jian-Guo Zhang" target="_self">Jian-Guo Zhang</a>, <a href="javascript:void(0);" id="thisauthor699681" class="author-name-link" data-f-name="Shu" data-l-name="Wang" data-name="Shu Wang" target="_self">Shu Wang</a> </div> <div id="dpaff"> <div><b>Yuan Zhang, Ming-Yan Hei, </b>Neonatal Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China</div><div><b>Min-Zhong Wang, </b>Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, Shandong Province, China</div><div><b>Jian-Guo Zhang, Shu Wang, </b>Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China</div> </div> <div id="dporcid" style="display:;"> <b>ORCID number: </b><span>Min-Zhong Wang (<a href='http://orcid.org/0000-0002-5765-182X' target='_blank'>0000-0002-5765-182X</a>); Shu Wang (<a href='http://orcid.org/0000-0002-5914-0804' target='_blank'>0000-0002-5914-0804</a>).</span> </div> <div id="dpfn"> <div><b>Author contributions</b>: Zhang Y collected the data, analyzed the data, and revised the manuscript; Hei MY, Wang MZ and Zhang JG designed the study, collected the data, analyzed the data, and revised the manuscript; Wang S designed the study, collected the data, analyzed the data, drafted the manuscript, and revised the manuscript. All the authors read and approved the final manuscript.</div> <div><b>Conflict-of-interest statement:</b> The authors declare that they have no conflicts of interest.</div><div><b>Open-Access:</b> This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: <a href="https://creativecommons.org/Licenses/by-nc/4.0/">https://creativecommons.org/Licenses/by-nc/4.0/</a></div><div><b>Corresponding author</b>: Shu Wang, MD, Neurosurgeon, Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Beijing 100070, China. <a href="mailto:wangshu.cn@outlook.com">wangshu.cn@outlook.com</a></div> <div><b>Received:</b> August 6, 2024<br /><b>Revised:</b> October 8, 2024<br /><b>Accepted:</b> October 22, 2024<br /><b>Published online:</b> November 19, 2024<br /><b>Processing time:</b> 92 Days and 22.6 Hours<br /></div> </div> <br /> </div>  <div id="article-abstract-container"> <div class="article-section-title-0"> <span>Abstract</span> </div> <div id="dpabstract"> <div><p>The adolescent years are a period of profound change, both physically and psychologically. For many, these years are marked by excitement and exploration, but for others, they are fraught with challenges that can lead to significant mental health issues. Depression, in particular, has become an increasingly prevalent concern among adolescents worldwide, and its multifaceted etiology requires a comprehensive approach to understanding and intervention. A recent study on the relationships among negative life events, dysfunctional attitudes, social support, and depressive symptoms in Chinese adolescents offers valuable insights into the complex interplay between various factors contributing to adolescent depression. The authors explore a moderated mediation model to better under<Hypen />stand how these factors interact with and contribute to the onset of depression. This article aims to delve into the key findings of the study, highlight its implications for clinical practice, and encourage further research in this critical area.</p> </div> <div class="article-abstract-item" style="display:;"> <b>Key Words: </b><span><a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Depression' target='blank'>Depression</a>; <a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Adolescent' target='blank'>Adolescent</a>; <a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Mental+health' target='blank'>Mental health</a>; <a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Dysfunctional+attitudes' target='blank'>Dysfunctional attitudes</a>; <a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Social+support' target='blank'>Social support</a>; <a href='https://www.f6publishing.com/ArticlesByKeywords?type=2&pageNumber=1&keyword=Negative+life+events' target='blank'>Negative life events</a></span> </div> <br /> <div class="article-abstract-item"> <span><p><b>Core Tip:</b> This article addresses a recent study examined the interplay between dysfunctional attitudes, social support, negative life events, and depressive symptoms in adolescents through a moderated mediation model. We focus on the need for comprehensive interventions that enhance social support systems, address dysfunctional thought patterns, and provide coping strategies for negative life events, ultimately informing more effective clinical practices and policies aimed at adolescent mental health.</p></span> </div> <div id="dpcitation" class="article-abstract-item rs_skip"> <hr /> <ul> <li> <b>Citation: </b>Zhang Y, Hei MY, Wang MZ, Zhang JG, Wang S. Unraveling the complexities of adolescent depression: A call for action. <i>World J Psychiatry</i> 2024; 14(11): 1772-1778 </li> <li> <b>URL: </b><a href="https://www.wjgnet.com/2220-3206/full/v14/i11/1772.htm" target="_self">https://www.wjgnet.com/2220-3206/full/v14/i11/1772.htm</a> </li> <li> <b>DOI: </b><a href="https://dx.doi.org/10.5498/wjp.v14.i11.1772" target="_self">https://dx.doi.org/10.5498/wjp.v14.i11.1772</a> </li> </ul> <hr/> </div> </div> </div>  <div id="article-main-container"> <div> <div id="sec11"><div id="sec11title" class="article-section-title-0">TO THE EDITOR</div><p class="article-section-content" id="p11">Adolescent depression is a significant public health concern affecting a substantial number of young people during their developmental years[<a class="refcontent" href="#B1" data-jats-ref-type="bibr" data-jats-rid="B1">1</a>,<a class="refcontent" href="#B2" data-jats-ref-type="bibr" data-jats-rid="B2">2</a>]. Characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities, it can profoundly impact all aspects of an adolescent's life, including academic performance, social relationships, and physical health, which could lead to serious consequences for individuals, families, and society at large[<a class="refcontent" href="#B3" data-jats-ref-type="bibr" data-jats-rid="B3">3</a>]. The prevalence of depression in adolescents varies, with estimates ranging from 5% to 8% in any given year, and lifetime prevalence rates are estimated at approximately 15% to 20%[<a class="refcontent" href="#B1" data-jats-ref-type="bibr" data-jats-rid="B1">1</a>,<a class="refcontent" href="#B4" data-jats-ref-type="bibr" data-jats-rid="B4">4</a>,<a class="refcontent" href="#B5" data-jats-ref-type="bibr" data-jats-rid="B5">5</a>]. The onset of depression often peaks between the ages of adolescence and young adulthood[<a class="refcontent" href="#B6" data-jats-ref-type="bibr" data-jats-rid="B6">6</a>]. The Global Burden of Disease Study (2021) reported that depression is one of the leading causes of disability among young people globally[<a class="refcontent" href="#B7" data-jats-ref-type="bibr" data-jats-rid="B7">7</a>]. Globally, there has been an increasing trend in depression among adolescents. Research indicates that depressive symptoms are particularly widespread among adolescents in China, a phenomenon that can be linked to the country's swift economic transformations, the rapid advancement of internet technology, and distinctive educational environment[<a class="refcontent" href="#B8" data-jats-ref-type="bibr" data-jats-rid="B8">8</a>,<a class="refcontent" href="#B9" data-jats-ref-type="bibr" data-jats-rid="B9">9</a>]. While many studies suggest that urbanization generally increases the burden of mental illness, research specific to China has revealed a different pattern. Depression is more prevalent in less urbanized areas of the country, possibly related to the lack of mental health courses in rural areas. In addition, the six-year follow-up showed that those in poorer health amongst these people were more likely to develop depression subsequently[<a class="refcontent" href="#B10" data-jats-ref-type="bibr" data-jats-rid="B10">10</a>]. A Chinese epidemiological study showed that 9.5% of 1007 adults with depression received treatment, while only 0.5% received adequate treatment. Although data on depression are scarce, depression has been gaining attention in China in recent years, and in 2021 the Chinese government announced a nationwide screening program for depression in children and adolescents[<a class="refcontent" href="#B11" data-jats-ref-type="bibr" data-jats-rid="B11">11</a>].</p><p class="article-section-content" id="p12">Adolescent depression is influenced by a complex interplay of genetic, biological, environmental, and psychosocial factors. Genetic predispositions play a significant role, as evidenced by higher rates of depression among children and adolescents with a family history of mood disorders[<a class="refcontent" href="#B12" data-jats-ref-type="bibr" data-jats-rid="B12">12</a>,<a class="refcontent" href="#B13" data-jats-ref-type="bibr" data-jats-rid="B13">13</a>]. Neurobiological factors, including imbalances in neurotransmitters such as serotonin, dopamine, and norepinephrine, have also been implicated[<a class="refcontent" href="#B14" data-jats-ref-type="bibr" data-jats-rid="B14">14</a>]. Environmental factors, such as stressful life events (<i>e.g.</i>, parental divorce, bullying), socioeconomic status, and exposure to violence, contribute significantly to the risk of developing depression[<a class="refcontent" href="#B15" data-jats-ref-type="bibr" data-jats-rid="B15">15</a>]. Psychosocial factors, including low self-esteem, poor peer relationships, and maladaptive coping strategies, further exacerbate risk[<a class="refcontent" href="#B16" data-jats-ref-type="bibr" data-jats-rid="B16">16</a>]. The transition through adolescence results in significant biological, psychological, and social changes, making this period particularly vulnerable to the onset of depressive disorders[<a class="refcontent" href="#B17" data-jats-ref-type="bibr" data-jats-rid="B17">17</a>]. Understanding the factors that contribute to the development of depression during this life stage is crucial for developing effective prevention and treatment strategies.</p></div><div id="sec12"><div id="sec12title" class="article-section-title-0">KEY FINDINGS AND IMPLICATIONS</div><p class="article-section-content" id="p11">The study by Yu <i>et al</i>[<a class="refcontent" href="#B18" data-jats-ref-type="bibr" data-jats-rid="B18">18</a>] is a valuable contribution to the field, offering a nuanced perspective on the relationships among negative life events, dysfunctional attitudes, social support, and depressive symptoms in Chinese adolescents. The authors employed a moderated mediation model to examine how social support moderates the impact of negative life events on depressive symptoms, which is mediated by specific dysfunctional attitudes.</p><div id="sec22"><div id="sec22title" class="article-section-title-1">The role of dysfunctional attitudes</div><p class="article-section-content" id="p21">Dysfunctional attitudes, defined as rigid and maladaptive beliefs about oneself, others, and the world, have been consistently linked to the onset and maintenance of depression[<a class="refcontent" href="#B19" data-jats-ref-type="bibr" data-jats-rid="B19">19</a>,<a class="refcontent" href="#B20" data-jats-ref-type="bibr" data-jats-rid="B20">20</a>]. The study highlights the role of two specific dysfunctional attitudes-perfectionism and autonomy-in the development of depressive symptoms. Perfectionistic attitudes, characterized by excessively high standards and critical self-evaluations, and autonomy, involving a strong need for independence and control, were found to mediate the effect of negative life events on depressive symptoms. These findings underscore the importance of addressing dysfunctional attitudes in the context of preventive interventions and therapeutic approaches aimed at reducing depressive symptoms in adolescents[<a class="refcontent" href="#B21" data-jats-ref-type="bibr" data-jats-rid="B21">21</a>].</p></div><div id="sec23"><div id="sec23title" class="article-section-title-1">The protective effect of social support</div><p class="article-section-content" id="p21">Social support, encompassing emotional, informational, and tangible assistance provided by family, friends, and community members, plays a crucial role in buffering against the negative effects of stressors[<a class="refcontent" href="#B22" data-jats-ref-type="bibr" data-jats-rid="B22">22</a>,<a class="refcontent" href="#B23" data-jats-ref-type="bibr" data-jats-rid="B23">23</a>]. The study revealed that social support acts as a protective factor, mitigating the impact of negative life events on depressive symptoms, particularly when adolescents hold dysfunctional attitudes. These findings support the notion that fostering strong social connections and enhancing social support networks can be powerful tools for preventing and treating depression in adolescents[<a class="refcontent" href="#B24" data-jats-ref-type="bibr" data-jats-rid="B24">24</a>,<a class="refcontent" href="#B25" data-jats-ref-type="bibr" data-jats-rid="B25">25</a>]. A social support system is comprised of three key components: The family, the school, and the community. Firstly, the government should incentivize businesses to implement flexible work schedules for parents, allowing them more time to engage with their children. Such deep emotional interactions can facilitate the early identification of children’s emotional issues, enabling timely and constructive responses that bolster their psychological resilience[<a class="refcontent" href="#B26" data-jats-ref-type="bibr" data-jats-rid="B26">26</a>]. Secondly, equipping schools with professional psychological counselors and instituting regular reviews and assessments of mental health education by the educational authorities can ensure that young individuals under significant psychological strain receive expert guidance. This approach also aids in fostering positive coping mechanisms among students. Lastly, government bodies can subsidize community mental health clinics to lower operational costs and promote enduring, stable collaborations between communities and healthcare providers. These partnerships are crucial for the early detection of adolescent mental health issues, while home visitation programs can enhance the mental well-being of adolescents by addressing and improving the family environment[<a class="refcontent" href="#B27" data-jats-ref-type="bibr" data-jats-rid="B27">27</a>].</p></div></div><div id="sec13"><div id="sec13title" class="article-section-title-0">CLINICAL AND PRACTICAL IMPLICATIONS</div><p class="article-section-content" id="p11">The findings of this study have several important implications for clinical practice and public health initiatives. First, the identification of specific dysfunctional attitudes as mediators in the relationship between negative life events and depressive symptoms suggests that targeted interventions aimed at modifying these attitudes could be beneficial[<a class="refcontent" href="#B28" data-jats-ref-type="bibr" data-jats-rid="B28">28</a>]. Cognitive-behavioral therapy, which focuses on challenging and changing unhelpful cognitive distortions and behaviors, is well suited to address perfectionism and autonomy-related attitudes[<a class="refcontent" href="#B29" data-jats-ref-type="bibr" data-jats-rid="B29">29</a><span>-</span><a class="refcontent" href="#B31" data-jats-ref-type="bibr" data-jats-rid="B31">31</a>]. Second, the protective role of social support highlights the need for community-based programs that promote social connectedness and foster supportive relationships among adolescents[<a class="refcontent" href="#B32" data-jats-ref-type="bibr" data-jats-rid="B32">32</a>,<a class="refcontent" href="#B33" data-jats-ref-type="bibr" data-jats-rid="B33">33</a>]. Schools, in particular, can play a pivotal role in facilitating these connections through peer support groups, mentorship programs, and parent–teacher collaborations[<a class="refcontent" href="#B34" data-jats-ref-type="bibr" data-jats-rid="B34">34</a><span>-</span><a class="refcontent" href="#B36" data-jats-ref-type="bibr" data-jats-rid="B36">36</a>].</p></div><div id="sec14"><div id="sec14title" class="article-section-title-0">FUTURE DIRECTIONS</div><p class="article-section-content" id="p11">While the study provides valuable insights, there are several areas where future research can build upon these findings. Longitudinal studies that track adolescents over time would help clarify the temporal sequence of events and the causal relationships between negative life events, dysfunctional attitudes, social support, and depressive symptoms[<a class="refcontent" href="#B37" data-jats-ref-type="bibr" data-jats-rid="B37">37</a>,<a class="refcontent" href="#B38" data-jats-ref-type="bibr" data-jats-rid="B38">38</a>]. Additionally, exploring cultural variations in the prevalence of dysfunctional attitudes and the effectiveness of social support across different societies would enrich our understanding of the universality of these findings[<a class="refcontent" href="#B39" data-jats-ref-type="bibr" data-jats-rid="B39">39</a>]. Furthermore, investigating the neurobiological underpinnings of these processes may reveal new targets for intervention and prevention efforts. While the study provides valuable insights, several areas for future research emerge.</p><div id="sec22"><div id="sec22title" class="article-section-title-1">Longitudinal studies</div><p class="article-section-content" id="p21">Longitudinal research could provide a clearer picture of the temporal relationships between negative life events, dysfunctional attitudes, social support, and the development of depressive symptoms over time.</p></div><div id="sec23"><div id="sec23title" class="article-section-title-1">Cultural factors</div><p class="article-section-content" id="p21">Further exploration of cultural differences in parenting styles and social support networks would enhance our understanding of how these factors influence adolescent mental health in various cultural contexts.</p></div><div id="sec24"><div id="sec24title" class="article-section-title-1">Intervention strategies</div><p class="article-section-content" id="p21">Based on these findings, targeted interventions that focus on enhancing social support networks, especially among adolescents with low social support, could be developed. These might include peer support groups, family therapy, and community-based programs.</p></div><div id="sec25"><div id="sec25title" class="article-section-title-1">Mechanisms of social support</div><p class="article-section-content" id="p21">Investigating the specific mechanisms through which social support exerts its protective effects could inform more effective intervention strategies.</p></div><div id="sec26"><div id="sec26title" class="article-section-title-1">Diverse populations</div><p class="article-section-content" id="p21">Expanding research to include diverse populations with cross-regional surveys and international cooperation, including rural <i>vs</i> urban communities, could provide a more comprehensive view of the role of social support in mitigating depression.</p></div></div><div id="sec15"><div id="sec15title" class="article-section-title-0">FOCUS OF POTENTIAL INFLUENCES FROM CORONAVIRUS DISEASE 2019</div><p class="article-section-content" id="p11">The coronavirus disease 2019 (COVID-19) pandemic has had profound effects on the mental health of adolescents, with a notable increase in the prevalence of depression[<a class="refcontent" href="#B40" data-jats-ref-type="bibr" data-jats-rid="B40">40</a>,<a class="refcontent" href="#B41" data-jats-ref-type="bibr" data-jats-rid="B41">41</a>]. The disruption caused by the pandemic has created a complex set of challenges that have contributed to this rise. The report showed that the most influential factors were age, and gender[<a class="refcontent" href="#B42" data-jats-ref-type="bibr" data-jats-rid="B42">42</a>].</p><div id="sec22"><div id="sec22title" class="article-section-title-1">Social isolation and disruption of social activities</div><p class="article-section-content" id="p21">Adolescents rely heavily on social interactions for emotional support and development. Quarantine measures, school closures, and restrictions on gatherings have led to prolonged periods of isolation, which can exacerbate feelings of loneliness and contribute to depressive symptoms[<a class="refcontent" href="#B43" data-jats-ref-type="bibr" data-jats-rid="B43">43</a>,<a class="refcontent" href="#B44" data-jats-ref-type="bibr" data-jats-rid="B44">44</a>].</p></div><div id="sec23"><div id="sec23title" class="article-section-title-1">Educational disruptions</div><p class="article-section-content" id="p21">School closures and the shift to remote learning have disrupted routines and structures, which are important for adolescent mental health. The sudden change in learning environments has led to increased stress, anxiety, and feelings of inadequacy, especially for those who struggle with online education[<a class="refcontent" href="#B45" data-jats-ref-type="bibr" data-jats-rid="B45">45</a>].</p></div><div id="sec24"><div id="sec24title" class="article-section-title-1">Increased screen time</div><p class="article-section-content" id="p21">With limited opportunities for outdoor activities and socialization, many adolescents have turned to digital devices for entertainment and communication. Excessive screen time, especially social media use, has been linked to higher rates of depression and anxiety in adolescents[<a class="refcontent" href="#B46" data-jats-ref-type="bibr" data-jats-rid="B46">46</a>,<a class="refcontent" href="#B47" data-jats-ref-type="bibr" data-jats-rid="B47">47</a>].</p></div><div id="sec25"><div id="sec25title" class="article-section-title-1">Economic stress and family dynamics</div><p class="article-section-content" id="p21">The economic downturn caused by the pandemic has resulted in financial strain for many families. Adolescents are sensitive to family stress, and economic hardship can lead to increased conflict and tension within the home environment, contributing to depression[<a class="refcontent" href="#B48" data-jats-ref-type="bibr" data-jats-rid="B48">48</a>].</p></div><div id="sec26"><div id="sec26title" class="article-section-title-1">Uncertainty and fear</div><p class="article-section-content" id="p21">The uncertainty surrounding the pandemic, including fears of illness and loss, can create a sense of helplessness and anxiety. Adolescents may worry about their own health and the health of loved ones, leading to chronic stress and depression[<a class="refcontent" href="#B41" data-jats-ref-type="bibr" data-jats-rid="B41">41</a>].</p></div><div id="sec27"><div id="sec27title" class="article-section-title-1">Limited access to mental health services</div><p class="article-section-content" id="p21">During the pandemic, many adolescents faced barriers to accessing mental health services due to lockdowns, the reduced availability of therapists, and concerns about safety. This lack of professional support can hinder the effective mana<Hypen />gement of depressive symptoms[<a class="refcontent" href="#B40" data-jats-ref-type="bibr" data-jats-rid="B40">40</a>].</p></div><div id="sec28"><div id="sec28title" class="article-section-title-1">Mitigating factors</div><p class="article-section-content" id="p21">Despite these challenges, some adolescents have shown resilience and adaptability. Supportive family environments, regular physical activity, and engagement in hobbies and interests have helped mitigate the negative effects of the pandemic on mental health[<a class="refcontent" href="#B49" data-jats-ref-type="bibr" data-jats-rid="B49">49</a>].</p><p class="article-section-content" id="p22">Thus, the COVID-19 pandemic has significantly impacted the mental health of adolescents, increasing the prevalence of depression[<a class="refcontent" href="#B50" data-jats-ref-type="bibr" data-jats-rid="B50">50</a>,<a class="refcontent" href="#B51" data-jats-ref-type="bibr" data-jats-rid="B51">51</a>]. Addressing these issues requires a multifaceted approach, including increased access to mental health resources, support systems for families, and efforts to maintain social connections and routines[<a class="refcontent" href="#B52" data-jats-ref-type="bibr" data-jats-rid="B52">52</a>]. Continued research and monitoring will be crucial for understanding the long-term effects of the pandemic on adolescent mental health, which could be helpful not only for preparing for future potential epidemics but also for the post-COVID-19 era[<a class="refcontent" href="#B53" data-jats-ref-type="bibr" data-jats-rid="B53">53</a>].</p></div></div><div id="sec16"><div id="sec16title" class="article-section-title-0">CONCLUSION</div><p class="article-section-content" id="p11">Understanding and effectively addressing adolescent depression is critical for promoting the long-term well-being of young individuals. Early intervention, comprehensive treatment approaches, and ongoing research into the etiology and management of depression are essential for improving outcomes and reducing the burden of this condition on adolescents and their families. Elucidating the complex interplay between negative life events, dysfunctional attitudes, social support, and depressive symptoms underscores the need for a multifaceted approach to address this growing public health concern. Clinicians, educators, policymakers, and researchers must work together to implement evidence-based practices that not only treat existing cases of depression but also prevent its onset. Through collaborative efforts, we can create a more supportive environment for adolescents, promoting resilience and mental well-being.</p></div><div id="sec17"><div id="sec17title" class="article-section-title-0">ACKNOWLEDGEMENTS</div><p class="article-section-content" id="p11">Dr. Shu Wang is a senior collaborator of the Global Burden of Disease Collaborator Network, which is supported by the Institute for Health Metrics and Evaluation, the University of Washington School of Medicine.</p></div> </div> <div class="article-section-title-0" style="display:block"> <span>Footnotes</span> </div> <div style="display:block;" class="article-section-content"> <p><bold>Provenance and peer review:</bold> Invited article; Externally peer reviewed.</p><p><bold>Peer-review model:</bold> Single blind</p><p><bold>Specialty type:</bold> Psychiatry</p><p><bold>Country of origin:</bold> China</p><p><bold>Peer-review report’s classification</bold></p><p><bold>Scientific Quality:</bold> Grade 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name='refsource'>Worldviews Evid Based Nurs</a></em>. 2022;<b>19</b>:130-137. </span> <span style="display:inline"> [<a href="http://www.ncbi.nlm.nih.gov/pubmed/35229967" pub-id-type="pubmed" pub-id="35229967" target="_blank">PubMed</a>]</span> <span style="display:inline"> [<a href="https://dx.doi.org/10.1111/wvn.12566" pub-id-type="doi" pub-id="10.1111/wvn.12566" target="_blank">DOI</a>]</span> <span> <span class="ref-count-sep">[</span>Cited in This Article: <span id="B51thiscited"></span><span class='ref-count-sep'>]</span></span> <span class="ref-count"> <span class="ref-count-sep">[</span>Cited by in Crossref: 6<span class='ref-count-sep'>]</span></span> <span class="ref-count"> <span class='ref-count-sep'>[</span><a href='/2220-3206/CitedArticlesInF6?id=10.1111%2fwvn.12566' target='_blank'>Cited by in F6Publishing: 50</a><span class='ref-count-sep'>]</span></span> <span class="ref-count"> <span class='ref-count-sep'>[</span><a href='javascript:void(0);' 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