CINXE.COM
Just a moment...
<!DOCTYPE html><html lang="en-US"><head><title>Just a moment...</title><meta http-equiv="Content-Type" content="text/html; charset=UTF-8"><meta http-equiv="X-UA-Compatible" content="IE=Edge"><meta name="robots" content="noindex,nofollow"><meta name="viewport" content="width=device-width,initial-scale=1"><style>*{box-sizing:border-box;margin:0;padding:0}html{line-height:1.15;-webkit-text-size-adjust:100%;color:#313131;font-family:system-ui,-apple-system,BlinkMacSystemFont,Segoe UI,Roboto,Helvetica Neue,Arial,Noto Sans,sans-serif,Apple Color Emoji,Segoe UI Emoji,Segoe UI Symbol,Noto Color Emoji}body{display:flex;flex-direction:column;height:100vh;min-height:100vh}.main-content{margin:8rem auto;max-width:60rem;padding-left:1.5rem}@media (width <= 720px){.main-content{margin-top:4rem}}.h2{font-size:1.5rem;font-weight:500;line-height:2.25rem}@media (width <= 720px){.h2{font-size:1.25rem;line-height:1.5rem}}#challenge-error-text{background-image:url(data:image/svg+xml;base64,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);background-repeat:no-repeat;background-size:contain;padding-left:34px}@media (prefers-color-scheme:dark){body{background-color:#222;color:#d9d9d9}}</style><meta http-equiv="refresh" content="390"></head><body class="no-js"><div class="main-wrapper" role="main"><div class="main-content"><noscript><div class="h2"><span id="challenge-error-text">Enable JavaScript and cookies to continue</span></div></noscript></div></div><script>(function(){window._cf_chl_opt={cvId: '3',cZone: "pubs.acs.org",cType: 'managed',cRay: '8e949a89eb045fb5',cH: '_3ruFj8q5pTvZ5VbEbldwuO286B4YVqfdfXbZ4yYvHo-1732736569-1.2.1.1-6GpqPzsF8_I0tDwT6Dw5iKuPTgdqNp0jq9MixMoZ6j392ArgfI88FBUCig4TRmmO',cUPMDTk: "\/doi\/10.1021\/om0343925?__cf_chl_tk=xWbGpVCVoudvIPVvjtgBsFe8TUO3bFKvoRLBpr3EnU0-1732736569-1.0.1.1-gWoVtfVb74_y9MtFPYHktCpU3iQF2Dl8zcpBHKa0z6I",cFPWv: 'b',cITimeS: '1732736569',cTTimeMs: '1000',cMTimeMs: '390000',cTplC: 0,cTplV: 5,cTplB: 'cf',cK: "",fa: "\/doi\/10.1021\/om0343925?__cf_chl_f_tk=xWbGpVCVoudvIPVvjtgBsFe8TUO3bFKvoRLBpr3EnU0-1732736569-1.0.1.1-gWoVtfVb74_y9MtFPYHktCpU3iQF2Dl8zcpBHKa0z6I",md: "cnjv1vndWE9gtgK0LHGjEtLBq2yQltkG.CQr1a5J69E-1732736569-1.2.1.1-Cx7jhwzvcLBq1HacVACMHSl2wTLLFaZkplWgSrJybAIeVjkk8Vv7rEUZ..87FtiKylfZye4mgLSZENn16HZiEtX8vdUK5XIvHwm6_stn1Uox44K7nxQRh_xeoF7K6uPFbwCgANYo5RMImrmSdI5Vv6Ex22xTTODANEQS3T.wdDoZEBMKi8DGQYC2UBMJrEChdqt0IK0OfbTDDTZbwuJksixVcXWFp4yn9qtYEg1KBVyGOcVGThh9EpaVOxTg9_I4uWR61R_mixlD2LJ4BZvtPo9tuQBrlsGDdUyVOU5OpKbOTqZXiPfQR9.E0ZNFgICEENvBhXxQAjq.3vStdA5HL_kLZAys3rUzbKm3TsZsB5tbHsxzV0xlSuQPwVn26ULgjQ8iwUlSub1WvwiX4xkz8F7aK8vsVPo1dsMAWjO.DGFGoh4YybvlxpXrMEp1Wk5gYksFD1wvUlvvVJC7aboLLVbZdg5_tlB6Ma97USdlsSwFOeGAso6xAqFFebRXP_GSczTB_i4o0rB7_YOf2MkH5nBBBwL4RHb.XPLHSB21qP1B1Uwl.AthHljrLJOZzZdnvrj3hHLCgrrcV8239q32j.j6.MvMxV_EAWJVzueokb3sUe29N._YQ9kkt.1UFVj0G2Krv13jnuWW.ucbMtGz7tnukJw67Kg4xDpO05ZEx7XGIGdX1rxWL0vYRg1ahBLpVDHxryWfCSyO4A3E54TzDQQsPvCepze3s35GhdrVFPiOgMJyfIywSQU278Ep0DeRb1nejn2OxSCRAUGjDN1wpGQ.Bo5xbzXJltv6o4mgNcZw4SkN61._L8F5FjM09ED3G4xmsmIti3ASrlHMQjwiZyi1o0IMhrsa8j4dbfS2m5LOcy5kB9_0qQtlxZcfJvKGL1dzAsgkJKlyNjyKoKqOUmB3BcDpAi2qStPM7Beu_WSDysz49hB0UM9ljb36PWqaR08mN1gMgnTwnH2nQGHqK7olYaOnvkoaafgiZIYAQhIuy.id7EVA.3m3GM8jMYr.PwCVePOb726nh2RmkuWqlEPSNZmA.tcuI_XY2O0xTyrqUKJ57EZ7J_CahVOS1p9Vl0KMCm.u.jkB_sJPeUUhaJMNYBlIbnTAJO_2f9LbrAJbHUuNYj2VQcAWwg8d9QHVF9P0Aqj92h66x28iMdL.9CL2jhzPhd..1hwE97RBaFSnxE0RFdzfd16x.jo2qf0pQe7prd.w58ea9cX7P35PZI_xamR16fcMj.hymuCkcfuQfmPP5M8S4WqnxnuB5X9wqho3ZYpkw76ou4w3kK4sNc.ZknRGaFmImR._jNmYSHdysJMKIqYajUkoTIVF1QCVg.sfO8rjo9mFuMjC1MjWn6bCrUl0IjmIL9OjyYEb_mmxAojyDdniXC1VJ6OhVg0u47k0IPTBAQrM_6akf3WitOf0gg34rKPj2blZIALbDicYz3VFEB4kdGsFAYAHnOTd6K1LDPj51xGDZ65YfE023dI2MjgyQ5aB3NruHBms8eN_CrJPO.gkarya.X5fMVcVnKiPOYd22jjLs.BILtAGpyLFK6vXWVYC1jUIPhqofvLNcDegS7YfstkTwzDQa59dhhs2wkZW8GZAkoEYTuCgTHVlqlhL0XMcmdGxFr.Pp2fg7MxP9dLysyE3wA_NLALzVALaX7kGsaZzOPcwJtHa082UTI1bvfXXFKFUUHqDG.PtkUogggJ63I_Z23KVOIJznP7L39FVz_aqrjg64zIScHj2KPCRq5JQhBYkTB9IfuBqL5FSmwc3stdpFZgaWbtZ_BkhZzt65uXaMDxunYkCkyhzE6GdYSz_4zL_8FeLzT7mDlq1Ib6C0WdgRyNWpnxEV2oXIRikH7t9Iqp.6ypazOACQOFJciDj6_6vzl_9UbB1gPy29DWsm3eCr6op3Kn2Ks69misgPsTVVw6df_umk12MIfr8bJiwz5C94ftcROPHwj.stKF7ZqhOsjZNyFe3vLiPNCeWyqh.jU6HwSbasqSfmVQN2YzXzYKpso4cdHU4uSJm6aheYo552BV0gCT263MfzLiyjsE79ygSuj5Ghq2wrhMQxQwjzz_O4if2S4HKoLdBbS10Xin44HW.3ybxwtiS2msCk7wd802yJuOAnn4.kXOzjptTERLzcZFyqxmmE5688bbsgmtgw9fBttPsgFkQJu7U76Et8tax4rzYgIkXqfYDjTHIO0I3olbthUnoCYSkCUPo4AA.e.XiDPwxVMhSSL1pTRPLOgizveAz2R46gfHu8oISK5yXatqlQz9QMghBRavSTIvpSiW7THICk.jSeD.CfnDlDCTiuas_i4uAePfT5kHkp.yzpt4SQIzdvPekxcsZPGck9.K994OcwG5FtR7AtgSfxvvRI2yzl0UQE2iWq4dR0CSqQm2yIq71ELwbDaOvyR1orVAYuHWTReeVHyiIIKZtCBdNOsBygJlbvGHIeDtiDat3bqMo9WuwfjAixo5oT.9zyaS_SagaN7O_9fCJnqu4rIroK1047VptaXqpEK0LFkUFzvIzPzFdF5WsVrtOLLVk3nAwxApRsWQNhS_gVfMXhwQi3Qz.PRwg9QSCp8rj.gLqPuCdUA3EMSRS_KlnfMry8DFJbHdpm5m2wXKDR1HxBzlA2Xffu9ADZrFFBLls3YdrJ0c18JrvX9HIE.wuWjGSIkoaYRgjAdYcxwaHiy.hMI0_LF4gfk5ytSBwR6QgBZX5opjsxaWB6BoGWLJfw9D4_1ocuG03qIOyqXKXxyFF7wQqal.OP0EFQ.SoekX.gtiKDNB6.O5OojYqo56LQAfLJIwUXEsVOyg_lJ4lgX8ZtVaDP4qeIsVptso5_RldbO7DtXVNZEHV.n6fDP3Drj4Fls4Nrjd8ZbkOvopzVXI9hw.ZIy6_e0tlRcKDb3R_Ma0UaNBD3NlHruEbTb8ITcvbrA.KJmuKIHIrDPPLU152VVQX5x1qBA",mdrd: "aXbx1kqkotvPq9nwYRW9x9KB610t4tQN8eAc3C.QHbw-1732736569-1.2.1.1-ODR93sT3gs8_z7TQNGOaXpoEidO76_W21XyFYZ0W.wfArWHbANKvclfVCLDu74hFue10IavdbHl.uoUle.VqyoPT7nx_nPzp3Kzrim40bR1CtR8i0zrNmcXsfBdYf0sNv2Dxz7zey7GA4r_Hu7s5fTRXB5.hgcYWtKnWKbp42FWwLqaNpqfBmwhnfL4sIPuPagBNT6fTlh3YV5_nuAT2o4bIYDBpgPDF.qEOh6gxYLebunAj5TtE4DhU_mB8JVUwGCKIKGD3KCwe1c97gsm8R7VFvM4ceQsh1H8PFUiBr7acHvCsMJHA4QOD9ZdL0HDEsso1qsRitLXB50ygdnAhfz1y7kx.iyGsFM1uQkscj8eW.dlIKr8_1t9kg1Q80n6b8MHdcXSs923cIUe_ug0DOuqkzpuyZGHLLYSIXEEdY_yaycXgMfDskpTyeLjjm2lNkp1eO6RoB1GusJ_WJNfspS7lXuwRs5eDQ.ClgOSGPzDASeNQvSktPz7uCZ35iB5xR2z3qqMfEwhTN2f1M1Udx1hweJteE9l9M810nWYD7Ny_te3.KPOCmcM1MfUfaJvz4rcboN5jzATy1pDqufW76VQSHZUU1OfF4zKLqEyksgQg_KJ.5uFaTtP8e2QN449wQfgloEXocpAapygKaLMFvHnznbydFf7cS8joK02SyGFkAvt5GEyyYsKPx3Gzkfsie4Hbcv5Tvq4WG9RgpfL0rSPlZrrgrxEmHtqo1BOFRdRfBXPB5gSz22NrJXPhphNWtlLq1pf.Pj4CsGHKbcG2E4NBHbemrmopDWOTuJjRo9gaqGEzEfHUFfAwqzyt6xVfUBuHCUES7tMtS46setybzdsGBsLt1Y3LdCxt5t.KEE0JF8qB2VKHRSWM_vrK_cRWqMWzNDyvS5w4eBPqyD4Y_rAMyyiUk3W9E03SvwDus1sCd4ekEtruN0kaY91BATTkoORqmCl04xglWV3_uSKHdO7tpGPvUsuTfgZn6ZEl4SIESGWRPnTxDiuH7joy63ejhrLtWuOT1sy.t83EHoQmB0dmlHFlCGfWQo8FCKFMuY8VvH_hg.L_YUhbOr28K5y88epQEDYIksY5Zn5T3MMynCZLqYBW6AkfYZr7ARopzn8qE3TpYrT8p6ac2Po5zjkaf3wEF65F0H7h4ib8s_8KIMJLkOv.tTKZy.OGDHbD35CY33HOwvxZg9GVYZy1YG_2daKMgOYrPxvLkzYrUqraf_J8fR_UBXVz5TlNvBL1UEY6jiT8qdQsxjNjfFhGnQbJgH21.eybZbTVgfL8Z9UtONLBWtcCCpI7VZPTaJSinY3ud9uDgqenbT2Q9DOXVcd637h_Kfv1DhpUwCNaRfxqpxQK4Zc5t0cqebfMm3BB33q407BxBURx.3RXqdHhKdl9VSuXWUGXnQQ4QxK18S8fCBmVNkKlsmR9k4a.RHTjSpvjO5qM0hr95DIs4JxiWg9THltydxYF.O1H0_gtludptssFih8pury6Eu1hE50iGDvnb10AjyD76goiNXWfte8._Z8MTrmI._pLRsYNu_ejramEjbcwT69EQpH3QgMNKFti4.SV2PxpiC75wDXN1MX70tVeQuRto4izNfZkKjBfIAFueBdIricHRrgBpmgO3B.wNwnGOFbQaEeJfbbADQkbQW83yDaJ0JNFnfAJrYGB4OFuJeYyJS8T8gtQ2pD6xeyr5Lyd_1iss0W7hz8BZBCI82pHLp4FNa6g4a66vm.BN3iuXiqqYS2uR_tO0WeNXRkV9wGR7VR69ooC5IEn16PLXc8IVoQJGR26bOaIR5ZLSomcREMqU1J.ixGwfO2nVRrK1ywpHThggvSafaLdfInAXPb.DDDyXwXQaxkJ.mUYrMCrnieMq__BfyRlFfd67NaxU2nbFzi3QWtgn6FF326t0aTH9UZ5BRKYk3GO62NXp36aFbMOqSZuwnOtqU3q0Y4"};var cpo = document.createElement('script');cpo.src = '/cdn-cgi/challenge-platform/h/b/orchestrate/chl_page/v1?ray=8e949a89eb045fb5';window._cf_chl_opt.cOgUHash = location.hash === '' && location.href.indexOf('#') !== -1 ? '#' : location.hash;window._cf_chl_opt.cOgUQuery = location.search === '' && location.href.slice(0, location.href.length - window._cf_chl_opt.cOgUHash.length).indexOf('?') !== -1 ? '?' : location.search;if (window.history && window.history.replaceState) {var ogU = location.pathname + window._cf_chl_opt.cOgUQuery + window._cf_chl_opt.cOgUHash;history.replaceState(null, null, "\/doi\/10.1021\/om0343925?__cf_chl_rt_tk=xWbGpVCVoudvIPVvjtgBsFe8TUO3bFKvoRLBpr3EnU0-1732736569-1.0.1.1-gWoVtfVb74_y9MtFPYHktCpU3iQF2Dl8zcpBHKa0z6I" + window._cf_chl_opt.cOgUHash);cpo.onload = function() {history.replaceState(null, null, ogU);}}document.getElementsByTagName('head')[0].appendChild(cpo);}());</script></body></html>