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href="http://dbpedia.org/resource/Brexpiprazole">Brexpiprazole</a> </h1> </div> </div> <div class="row"> <div class="col"> <div class="text-muted"> An Entity of Type: <a href="http://dbpedia.org/ontology/ChemicalSubstance">chemical substance</a>, from Named Graph: <a href="http://dbpedia.org">http://dbpedia.org</a>, within Data Space: <a href="http://dbpedia.org">dbpedia.org</a> </div> </div> </div> <div class="row pt-2"> <div class="col-xs-9 col-sm-10"> Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). The drug was approved by the U.S. Food and Drug Administration (FDA) on 10 July 2015, for the treatment of schizophrenia, and as an adjunctive treatment for depression. It has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD). </div> <div class="col-xs-3 col-sm-2"> <a href="#" class="thumbnail"> <img src="http://commons.wikimedia.org/wiki/Special:FilePath/Brexpiprazole.svg?width=300" alt="thumbnail" class="img-fluid" /> </a> </div> </div> </div> </section>   <section> <div class="container-xl"> <div class="row"> <div class="table-responsive"> <table class="table table-hover table-sm table-light"> <thead> <tr> <th class="col-xs-3 ">Property</th> <th class="col-xs-9 px-3">Value</th> </tr> </thead> <tbody> <tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/ontology/abstract">dbo:abstract</a> </td><td class="col-10 text-break"><ul> <li style="display:none;">بريكسبيبريزول (بالإنجليزية: Brexpiprazole)‏ هو دواء يُستعمل في علاج: * ذهان * اضطراب فصامي عاطفي * قلق (ar)</li> <li>Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). The drug was approved by the U.S. Food and Drug Administration (FDA) on 10 July 2015, for the treatment of schizophrenia, and as an adjunctive treatment for depression. It has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD). The drug was developed by Otsuka and Lundbeck, and is considered to be a successor of Otsuka's top-selling atypical antipsychotic aripiprazole (Abilify). It is available as a generic medication. (en)</li> <li style="display:none;">Brexpiprazol ist ein Wirkstoff aus der Gruppe der Antipsychotika und wird in der Behandlung der Schizophrenie eingesetzt. (de)</li> <li style="display:none;">Le Brexpiprazole (code produit: OPC-34712) est un agoniste partiel des récepteurs de dopamine D2 développé par Otsuka et Lundbeck. Son nom commercial est Rexulti. Il est actuellement en phase d'étude clinique pour le traitement de la dépression majeure, de la schizophrénie et du trouble du déficit de l'attention . Le produit a été initialement conçu pour offrir une alternative à l'aripiprazole, offrant une plus grande efficacité et moins d'effets secondaires (notamment akathisie, agitation psychomotrice et insomnies. Mais à ce jour, seule une étude comparant l'aripiprazole est terminée et ne démontre aucune différence d'efficacité entre aripiprazole et brexpiprazole . Pour Ostuka, le brexpiprazole est destiné à être le successeur de l'antipsychotique aripiprazole, dont le brevet américain expire en octobre 2014 (mais qui bénéficie d'une extension de 6 mois due à l'exclusivité pédiatrique). (fr)</li> <li style="display:none;">O brexpiprazol(pt-BR) ou brexpiprazole(pt-PT?) (nomes comerciais: Rexulti, Rxulti, entre outros) é um antipsicótico atípico, da classe dos aceleradores e moduladores de serotonina (AMS), que atua como agonista parcial do receptor D2 de dopamina. Em 10 de julho de 2015, a droga foi aprovada nos Estados Unidos pela Food and Drug Administration (FDA) para tratamento de esquizofrenia e tratamento adjuvante para casos de depressão. O brexpripazol foi projetado para fornecer maior eficácia e tolerabilidade em relação aos tratamentos adjuvantes estabelecidos para transtorno depressivo maior (por exemplo, produz menos efeitos colaterais, como acatisia, inquietação e/ou insônia). A droga foi desenvolvida pelas companhias farmacêuticas Otsuka e Lundbeck, e é considerada uma sucessora do antipsicótico atípico aripiprazol. (pt)</li> <li style="display:none;">Brekspiprazol – wielofunkcyjny organiczny związek chemiczny, stosowany jako lek przeciwpsychotyczny. Lek otrzymał zgodę Agencji Żywności i Leków (FDA) w lipcu 2015 roku na rejestrację w leczeniu objawów schizofrenii i jako pomocniczy lek w dużej depresji. Lek został opracowany i wprowadzony na rynek farmaceutyczny przez firmy farmaceutyczne i Lundbeck. W grudniu 2021 zatwierdziła brekspiprazol do leczenia schizofrenii u młodzieży w wieku 13-17, na podstawie ekstrapolacji danych klinicznych uzyskanych z leczenia osób dorosłych (pl)</li> <li style="display:none;">Brexpiprazol är aktiv substans i ett neuroleptiskt läkemedel. Handelsnamn i Sverige är Rxulti och i USA Rexulti. Läkemedlet används för behandling av depression men även schizofreni. Brexpiprazol utvecklades fram genom ett samarbete mellan och Lundbeck och anses vara en efterföljare av Otsukas mest sålda atypiska antipsykotiska, det vill säga aripiprazol (Abilify). 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(xsd:integer)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/kegg">dbp:kegg</a> </td><td class="col-10 text-break"><ul> <li>D10309 (en)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/legalAu">dbp:legalAu</a> </td><td class="col-10 text-break"><ul> <li>S4 (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/legalEu">dbp:legalEu</a> </td><td class="col-10 text-break"><ul> <li>Rx-only (en)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/legalUs">dbp:legalUs</a> </td><td class="col-10 text-break"><ul> <li>Rx-only (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/licenceEu">dbp:licenceEu</a> </td><td class="col-10 text-break"><ul> <li>yes (en)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/licenceUs">dbp:licenceUs</a> </td><td class="col-10 text-break"><ul> <li>Brexpiprazole (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/medlineplus">dbp:medlineplus</a> </td><td class="col-10 text-break"><ul> <li>a615046 (en)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/metabolism">dbp:metabolism</a> </td><td class="col-10 text-break"><ul> <li>Hepatic (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/n">dbp:n</a> </td><td class="col-10 text-break"><ul> <li>3 (xsd:integer)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/o">dbp:o</a> </td><td class="col-10 text-break"><ul> <li>2 (xsd:integer)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/pregnancyAu">dbp:pregnancyAu</a> 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rel="dbp:title" resource="http://dbpedia.org/resource/Pharmacodynamics" href="http://dbpedia.org/resource/Pharmacodynamics">dbr:Pharmacodynamics</a></li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/titlestyle">dbp:titlestyle</a> </td><td class="col-10 text-break"><ul> <li>background:#ccccff (en)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/tradename">dbp:tradename</a> </td><td class="col-10 text-break"><ul> <li>Rexulti, Rxulti (en)</li> </ul></td></tr><tr class="even"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/unii">dbp:unii</a> </td><td class="col-10 text-break"><ul> <li>2 (xsd:integer)</li> </ul></td></tr><tr class="odd"><td class="col-2"><a class="uri" href="http://dbpedia.org/property/width">dbp:width</a> </td><td class="col-10 text-break"><ul> <li>175 (xsd:integer)</li> <li>250 (xsd:integer)</li> </ul></td></tr><tr class="even"><td 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Brexpiprazole)‏ هو دواء يُستعمل في علاج: * ذهان * اضطراب فصامي عاطفي * قلق (ar)</li> <li style="display:none;">Brexpiprazol ist ein Wirkstoff aus der Gruppe der Antipsychotika und wird in der Behandlung der Schizophrenie eingesetzt. (de)</li> <li style="display:none;">Brekspiprazol – wielofunkcyjny organiczny związek chemiczny, stosowany jako lek przeciwpsychotyczny. Lek otrzymał zgodę Agencji Żywności i Leków (FDA) w lipcu 2015 roku na rejestrację w leczeniu objawów schizofrenii i jako pomocniczy lek w dużej depresji. Lek został opracowany i wprowadzony na rynek farmaceutyczny przez firmy farmaceutyczne i Lundbeck. W grudniu 2021 zatwierdziła brekspiprazol do leczenia schizofrenii u młodzieży w wieku 13-17, na podstawie ekstrapolacji danych klinicznych uzyskanych z leczenia osób dorosłych (pl)</li> <li style="display:none;">Brexpiprazol är aktiv substans i ett neuroleptiskt läkemedel. Handelsnamn i Sverige är Rxulti och i USA Rexulti. Läkemedlet används för behandling av depression men även schizofreni. Brexpiprazol utvecklades fram genom ett samarbete mellan och Lundbeck och anses vara en efterföljare av Otsukas mest sålda atypiska antipsykotiska, det vill säga aripiprazol (Abilify). (sv)</li> <li>Brexpiprazole, sold under the brand name Rexulti among others, is an atypical antipsychotic. It is a dopamine D2 receptor partial agonist and has been described as a "serotonin–dopamine activity modulator" (SDAM). The drug was approved by the U.S. Food and Drug Administration (FDA) on 10 July 2015, for the treatment of schizophrenia, and as an adjunctive treatment for depression. It has been designed to provide improved efficacy and tolerability (e.g., less akathisia, restlessness and/or insomnia) over established adjunctive treatments for major depressive disorder (MDD). (en)</li> <li style="display:none;">Le Brexpiprazole (code produit: OPC-34712) est un agoniste partiel des récepteurs de dopamine D2 développé par Otsuka et Lundbeck. Son nom commercial est Rexulti. Il est actuellement en phase d'étude clinique pour le traitement de la dépression majeure, de la schizophrénie et du trouble du déficit de l'attention . Le produit a été initialement conçu pour offrir une alternative à l'aripiprazole, offrant une plus grande efficacité et moins d'effets secondaires (notamment akathisie, agitation psychomotrice et insomnies. Mais à ce jour, seule une étude comparant l'aripiprazole est terminée et ne démontre aucune différence d'efficacité entre aripiprazole et brexpiprazole . (fr)</li> <li style="display:none;">O brexpiprazol(pt-BR) ou brexpiprazole(pt-PT?) (nomes comerciais: Rexulti, Rxulti, entre outros) é um antipsicótico atípico, da classe dos aceleradores e moduladores de serotonina (AMS), que atua como agonista parcial do receptor D2 de dopamina. Em 10 de julho de 2015, a droga foi aprovada nos Estados Unidos pela Food and Drug Administration (FDA) para tratamento de esquizofrenia e tratamento adjuvante para casos de depressão. O brexpripazol foi projetado para fornecer maior eficácia e tolerabilidade em relação aos tratamentos adjuvantes estabelecidos para transtorno depressivo maior (por exemplo, produz menos efeitos colaterais, como acatisia, inquietação e/ou insônia). 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