CINXE.COM
Oncostatin M (OSM) Signaling Pathways: R&D Systems
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data-form="pathways_il-21_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-21 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-27_p28_il-30_signaling_pathways" action="/pathways/il-27-p28il-30-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-27-p28il-30-signaling-pathways" class="pathway_link" data-form="pathways_il-27_p28_il-30_signaling_pathways"> IL-27 p28/IL-30 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-31_signaling_pathways" action="/pathways/il-31-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-31-signaling-pathways" class="pathway_link" data-form="pathways_il-31_signaling_pathways"> IL-31 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways" action="/pathways/il4-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il4-signaling-pathways" class="pathway_link" data-form="pathways_il-4_signaling_pathways"> IL-4 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-4-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-4_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-6_signaling_pathways" action="/pathways/il-6-family-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il-6-family-signaling-pathways" class="pathway_link" data-form="pathways_il-6_signaling_pathways"> IL-6 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways" action="/pathways/il7-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il7-signaling-pathways" class="pathway_link" data-form="pathways_il-7_signaling_pathways"> IL-7 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-7-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-7_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-7 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways" action="/pathways/il9-signaling-pathways" method="post"> <li class=""> <a href="/pathways/il9-signaling-pathways" class="pathway_link" data-form="pathways_il-9_signaling_pathways"> IL-9 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types" action="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" method="post"> <li class=""> <a href="/pathways/il-9-signaling-pathways-their-primary-biological-effects-in-different-immune-cell-types" class="pathway_link" data-form="pathways_il-9_signaling_pathways_and_their_primary_biological_effects_in_different_immune_cell_types"> IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_inflammasome_activation_pathways" action="/pathways/inflammasome-activation-pathways" method="post"> <li class=""> <a href="/pathways/inflammasome-activation-pathways" class="pathway_link" data-form="pathways_inflammasome_activation_pathways"> Inflammasome Activation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_innate_lymphoid_cell_differentiation_pathways" action="/pathways/innate-lymphoid-cell-differentiation-pathways" method="post"> <li class=""> <a href="/pathways/innate-lymphoid-cell-differentiation-pathways" class="pathway_link" data-form="pathways_innate_lymphoid_cell_differentiation_pathways"> Innate Lymphoid Cell Differentiation Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_lif_signaling_pathways" action="/pathways/lif-signaling-pathways" method="post"> <li class=""> <a href="/pathways/lif-signaling-pathways" class="pathway_link" data-form="pathways_lif_signaling_pathways"> LIF Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mdsc-mediated_mechanisms_of_immunosuppression" action="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" method="post"> <li class=""> <a href="/pathways/mdsc-mediated-mechanisms-of-immunosuppression" class="pathway_link" data-form="pathways_mdsc-mediated_mechanisms_of_immunosuppression"> MDSC-Mediated Mechanisms of Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression" action="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" method="post"> <li class=""> <a href="/pathways/mechanisms-of-regulatory-t-cell-mediated-suppression" class="pathway_link" data-form="pathways_mechanisms_of_regulatory_t_cell-mediated_suppression"> Mechanisms of Regulatory T Cell-Mediated Suppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression" action="/pathways/tumor-associated-macrophage-tam" method="post"> <li class=""> <a href="/pathways/tumor-associated-macrophage-tam" class="pathway_link" data-form="pathways_mechanisms_of_tumor-associated_macrophage_tam-mediated_immunosuppression"> Mechanisms of Tumor-Associated Macrophage TAM-Mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression" action="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" method="post"> <li class=""> <a href="/pathways/mechanisms-tumor-derived-exosome-tex-mediated-immunosuppression" class="pathway_link" data-form="pathways_mechanisms_of_tumor-derived_exosome_tex-mediated_immunosuppression"> Mechanisms of Tumor-derived Exosome TEX-mediated Immunosuppression </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions" action="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" method="post"> <li class=""> <a href="/pathways/natural-killer-cell-receptors-human-target-cell-nk-cell-ligand-receptor-interactions-pathway" class="pathway_link" data-form="pathways_natural_killer_cell_receptors__human_target_cell_–_nk_cell_ligand-receptor_interactions"> Natural Killer Cell Receptors: Human Target Cell – NK Cell Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_neuropoietin_signaling_pathways" action="/pathways/neuropoietin-signaling-pathways" method="post"> <li class=""> <a href="/pathways/neuropoietin-signaling-pathways" class="pathway_link" data-form="pathways_neuropoietin_signaling_pathways"> Neuropoietin Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_nod-like_receptor_signaling_pathways" action="/pathways/nod-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/nod-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_nod-like_receptor_signaling_pathways"> NOD-like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_oncostatin_m_signaling_pathways" action="/pathways/oncostatin-m-signaling-pathways" method="post"> <li class="active"> <a href="/pathways/oncostatin-m-signaling-pathways" class="pathway_link" data-form="pathways_oncostatin_m_signaling_pathways"> Oncostatin M Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways" action="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/pathogen-damage-activated-c-type-lectin-receptor-signaling-pathways" class="pathway_link" data-form="pathways_pathogen_or_damage-activated_c-type_lectin_receptor_signaling_pathways"> Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions" action="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" method="post"> <li class=""> <a href="/pathways/t-cell-co-signaling-pathway-lig-recept-interactions" class="pathway_link" data-form="pathways_t_cell_co-signaling_pathway__ligand-receptor_interactions"> T Cell Co-Signaling Pathway: Ligand-Receptor Interactions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tgf-beta_signaling_pathways" action="/pathways/tgf-beta-signaling-pathways" method="post"> <li class=""> <a href="/pathways/tgf-beta-signaling-pathways" class="pathway_link" data-form="pathways_tgf-beta_signaling_pathways"> TGF-beta Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th1_differentiation_pathway" action="/pathways/th1-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th1-differentiation-pathway" class="pathway_link" data-form="pathways_th1_differentiation_pathway"> Th1 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th17_differentiation_pathway" action="/pathways/th17-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th17-differentiation-pathway" class="pathway_link" data-form="pathways_th17_differentiation_pathway"> Th17 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_th2_differentiation_pathway" action="/pathways/th2-differentiation-pathway" method="post"> <li class=""> <a href="/pathways/th2-differentiation-pathway" class="pathway_link" data-form="pathways_th2_differentiation_pathway"> Th2 Differentiation Pathway </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions" action="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" method="post"> <li class=""> <a href="/pathways/tnf-superfamily-pathway-human-lig-recept-interactions-their-associated-functions" class="pathway_link" data-form="pathways_tnf_superfamily_pathway__human_ligand-receptor_interactions__their_associated_functions"> TNF Superfamily Pathway: Human Ligand-Receptor Interactions & their Associated Functions </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_toll-like_receptor_signaling_pathways" action="/pathways/toll-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/toll-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_toll-like_receptor_signaling_pathways"> Toll-Like Receptor Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_i_interferon_signaling_pathways" action="/pathways/type-i-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-i-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_i_interferon_signaling_pathways"> Type I Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_ii_interferon_signaling_pathways" action="/pathways/type-ii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-ii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_ii_interferon_signaling_pathways"> Type II Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_type_iii_interferon_signaling_pathways" action="/pathways/type-iii-interferon-signaling-pathways" method="post"> <li class=""> <a href="/pathways/type-iii-interferon-signaling-pathways" class="pathway_link" data-form="pathways_type_iii_interferon_signaling_pathways"> Type III Interferon Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_vegf_-_vegf_r2_signaling_pathways" action="/pathways/vegf-vegf-r2-signaling-pathways" method="post"> <li class=""> <a href="/pathways/vegf-vegf-r2-signaling-pathways" class="pathway_link" data-form="pathways_vegf_-_vegf_r2_signaling_pathways"> VEGF - VEGF R2 Signaling Pathways </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> <form id="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr" action="/pathways/rig-i-like-receptor-signaling-pathways" method="post"> <li class=""> <a href="/pathways/rig-i-like-receptor-signaling-pathways" class="pathway_link" data-form="pathways_virus_detection_and_induction_of_antiviral_signaling_pathways_by_rig-i-like_receptors_rlr"> Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors RLR </a> </li> <input type="hidden" name="pw_parent" value="Immunology"> </form> </ul> </li> <li class="pathways-li "> <form id="pathways_neuroscience_pathways" action="/pathways/neuroscience" method="post"> <a href="/pathways/neuroscience" data-form="pathways_neuroscience_pathways" class="pathway_link"> <span class="icon-"> Neuroscience Pathways </span> </a> <input type="hidden" name="pw_parent" value="Neuroscience"> </form> </li> <li class="pathways-li "> <form id="pathways_proteases__other_enzymes_pathways" action="/pathways/proteases" method="post"> <a href="/pathways/proteases" data-form="pathways_proteases__other_enzymes_pathways" class="pathway_link"> <span class="icon-"> Proteases & Other Enzymes Pathways </span> </a> <input type="hidden" name="pw_parent" value="proteases"> </form> </li> <li class="pathways-li "> <form id="pathways_signal_transduction_pathways" action="/pathways/signal-transduction" method="post"> <a href="/pathways/signal-transduction" data-form="pathways_signal_transduction_pathways" class="pathway_link"> <span class="icon-"> Signal Transduction Pathways </span> </a> <input type="hidden" name="pw_parent" value="signal-transduction"> </form> </li> <li class="pathways-li "> <form id="pathways_stem_cell_pathways" action="/pathways/stem-cells" method="post"> <a href="/pathways/stem-cells" data-form="pathways_stem_cell_pathways" class="pathway_link"> <span class="icon-"> Stem Cell Pathways </span> </a> <input type="hidden" name="pw_parent" value="stem-cells"> </form> </li> <li class="pathways-li "> <form id="pathways_ubiquitin_related_modifiers__pathways" action="/pathways/ubiquitin-related-modifiers-and-pathways" method="post"> <a href="/pathways/ubiquitin-related-modifiers-and-pathways" data-form="pathways_ubiquitin_related_modifiers__pathways" class="pathway_link"> <span class="icon-"> Ubiquitin, Related Modifiers, & Pathways </span> </a> <input type="hidden" name="pw_parent" value="ubiquitin-related-modifiers-and-pathways"> </form> </li> </ul> </div> </div> </div> </div> </div> <div class="pw_right col-xs-12 col-sm-8 col-md-9"> <div class="search_mobile_buttons"> <div class="pw_menu_toggle btn btn-tertiary">Show Categories</div> </div> <div class="pw_header"> <h1>Oncostatin M Signaling Pathways</h1> <p id="pw-intro-txt">Click on the other IL-6 family cytokines shown in the Explore Pathways box below to see the signaling pathways that are activated by each cytokine. Refer to the table below each pathway to see a select list of cytokine-expressing cells or tissues and the primary biological effects induced by the different members of the IL-6 cytokine family.<br></p> <div id="pw-con" data-mapname="" data-primary_segment="il-6family_osm"> <div id="pw-main-nav-wrapper"> <div class="row"> <div id="pw-button-nav-top" class="col-xs-12 col-sm-12"> <div class="row"> <div id="pw-button-nav"> <div class="dropdown col-xs-12 col-sm-6 col-md-4"> <button class="btn-pw" type="button" data-toggle="dropup">Explore Pathways<span class="caret"></span></button> <ul id="pathwaynav" class="dropdown-content"><li class="pw_rdblue_sm pw_sm_btn"><a href="/il-6-family-signaling-pathways"><span>IL-6</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/il-11-signaling-pathways"><span>IL-11</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/il-27-p28il-30-signaling-pathways"><span>IL-27 p28/IL-30</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/il-31-signaling-pathways"><span>IL-31</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/lif-signaling-pathways"><span>LIF</span></a></li> <li class="pw_sm_btn-active"><a href="/oncostatin-m-signaling-pathways"><span>Oncostatin M</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/cardiotrophin-signaling-pathways"><span>Cardiotrophin-1</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/cardiotrophin-cytokine-clc-signaling-pathways"><span>Cardiotrophin-like Cytokine (CLC)</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/cntf-signaling-pathways"><span>CNTF</span></a></li> <li class="pw_rdblue_sm pw_sm_btn"><a href="/neuropoietin-signaling-pathways"><span>Neuropoietin</span></a></li> </ul> </div> </div> <div class="col-xs-12 col-sm-6 col-md-5" > <div id="pw-nav-subtitle"> Oncostatin M Signaling Pathways </div> </div> <div id="pw-print-button-col" class="col-xs-12 col-sm-6 col-md-3" > <a href="#print-copy-form" id="btn-get-print-copy" class="btn btn-primary"><img class="btn-icon" src="https://resources.rndsystems.com/images/Pathways/icons/icon-image.svg"/> Get Print Copy</a> </div> </div> </div> </div> </div> <div id="pw-map"> <div id="pw-maps"> <div id="el1_gry" class="il-6family_osm pw-sprite el-gray1 pw-gray" style="top:181.6666717529297px;left:362.66668701171875px;"> </div> <div id="el1_off" data-id="1" data-set="OncostatinMOSM163" data-type="" class="il-6family_osm pw-sprite el-off1" style="top:181.6666717529297px;left:362.66668701171875px;"> </div> <div id="el1_ct" class="pw-tooltip" data-id="1"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/oncostatin-m-osm">OSM</a><br> </div> </div> <div id="el2_gry" class="il-6family_osm pw-label el-gray2 pw-gray" style="top:167.6666717529297px;left:317.66668701171875px;"> Oncostatin M (OSM) </div> <div id="el2_off" data-id="2" data-set="OncostatinMOSM163" data-type="No Products Click" class="il-6family_osm pw-label el-off2" style="top:167.6666717529297px;left:317.66668701171875px;"> Oncostatin M (OSM)</div> <div id="el2_ct" class="pw-tooltip" data-id="2"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/oncostatin-m-osm">OSM</a><br> </div> </div> <div id="el3_gry" class="il-6family_osm pw-label2 el-gray3 pw-gray" style="top:215.33334350585938px;left:294.66668701171875px;"> Type I </div> <div id="el3_off" data-id="3" data-set="TypeI" data-type="" class="il-6family_osm pw-label2 el-off3" style="top:215.33334350585938px;left:294.66668701171875px;"> Type I</div> <div id="el3_ct" class="pw-tooltip" data-id="3"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el4_gry" class="il-6family_osm pw-label2 el-gray4 pw-gray" style="top:216px;left:425.66668701171875px;"> Type II </div> <div id="el4_off" data-id="4" data-set="TypeII" data-type="" class="il-6family_osm pw-label2 el-off4" style="top:216px;left:425.66668701171875px;"> Type II</div> <div id="el4_ct" class="pw-tooltip" data-id="4"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el5_gry" class="il-6family_osm pw-sprite el-gray5 pw-gray" style="top:257.66668701171875px;left:267.66668701171875px;"> </div> <div id="el5_off" data-id="5" data-set="LIFR166" data-type="" class="il-6family_osm pw-sprite el-off5" style="top:257.66668701171875px;left:267.66668701171875px;"> </div> <div id="el5_ct" class="pw-tooltip" data-id="5"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/lif-r-alpha">LIF R alpha</a><br> </div> </div> <div id="el6_gry" class="il-6family_osm pw-label el-gray6 pw-gray" style="top:280px;left:313.66668701171875px;"> LIF R </div> <div id="el6_off" data-id="6" data-set="LIFR166" data-type="No Products Click" class="il-6family_osm pw-label el-off6" style="top:280px;left:313.66668701171875px;"> LIF R</div> <div id="el6_ct" class="pw-tooltip" data-id="6"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/lif-r-alpha">LIF R alpha</a><br> </div> </div> <div id="el7_gry" class="il-6family_osm pw-sprite el-gray7 pw-gray" style="top:302.66668701171875px;left:282.66668701171875px;"> </div> <div id="el7_off" data-id="7" data-set="OSM167" data-type="No Products Click" class="il-6family_osm pw-sprite el-off7" style="top:302.66668701171875px;left:282.66668701171875px;"> </div> <div id="el7_ct" class="pw-tooltip" data-id="7"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/oncostatin-m-osm">OSM</a><br> </div> </div> <div id="el8_gry" class="il-6family_osm pw-label el-gray8 pw-gray" style="top:343.66668701171875px;left:236.66668701171875px;"> OSM </div> <div id="el8_off" data-id="8" data-set="OSM167" data-type="No 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style="top:390.3333435058594px;left:403.66668701171875px;"> </div> <div id="el31_off" data-id="31" data-set="Jak1179" data-type="No Products Click" class="il-6family_osm pw-sprite el-off31" style="top:390.3333435058594px;left:403.66668701171875px;"> </div> <div id="el31_ct" class="pw-tooltip" data-id="31"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/jak1">Jak1</a><br> </div> </div> <div id="el32_gry" class="il-6family_osm pw-label el-gray32 pw-gray" style="top:403.66668701171875px;left:386.66668701171875px;"> Jak1 </div> <div id="el32_off" data-id="32" data-set="Jak1179" data-type="No Products Click" class="il-6family_osm pw-label el-off32" style="top:403.66668701171875px;left:386.66668701171875px;"> Jak1</div> <div id="el32_ct" class="pw-tooltip" data-id="32"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/jak1">Jak1</a><br> </div> </div> <div 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class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray40 pw-gray" style="top:468px;left:195.66668701171875px;"> IRS1/2 </div> <div id="el40_off" data-id="40" data-set="IRS12337" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off40" style="top:468px;left:195.66668701171875px;"> IRS1/2</div> <div id="el40_ct" class="pw-tooltip" data-id="40"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/irs1">IRS1</a><br><a href="/target/irs2">IRS2</a><br> </div> </div> <div id="el41_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray41 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style="top:569.3333435058594px;left:125.66668701171875px;"> </div> <div id="el53_off" data-id="53" data-set="PI3-K344" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off53" style="top:569.3333435058594px;left:125.66668701171875px;"> </div> <div id="el53_ct" class="pw-tooltip" data-id="53"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pi-3-kinase-p55-gamma">PI 3-kinase p55 gamma</a><br><a href="/target/pi-3-kinase-p85-alpha">PI 3-Kinase p85 alpha</a><br><a href="/target/pi-3-kinase-p85-beta">PI 3-Kinase p85 beta</a><br><a href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a href="/search?keywords=pi3k">All PI 3-K 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href="/target/pi-3-kinase-p110-beta">PI 3-Kinase p110 beta</a><br><a href="/target/pi-3-kinase-p110-gamma">PI 3-Kinase p110 gamma</a><br><a href="/target/pi-3-kinase-p110-delta">PI 3-Kinase p110 delta</a><br><a href="/search?keywords=pi3k">All PI 3-K Products</a><br> </div> </div> <div id="el55_gry" class="il-6family_osm pw-sprite el-gray55 pw-gray" style="top:669px;left:170.66668701171875px;"> </div> <div id="el55_off" data-id="55" data-set="PKCdelta345" data-type="No Products Click" class="il-6family_osm pw-sprite el-off55" style="top:669px;left:170.66668701171875px;"> </div> <div id="el55_ct" class="pw-tooltip" data-id="55"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pkc-delta">PKC delta</a><br> </div> </div> <div id="el56_gry" class="il-6family_osm pw-label el-gray56 pw-gray" style="top:672.3333435058594px;left:192.66668701171875px;"> PKC delta </div> <div id="el56_off" data-id="56" data-set="PKCdelta345" 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data-id="57"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el58_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray58 pw-gray" style="top:401px;left:151.66668701171875px;"> PIP<sub>2</sub> </div> <div id="el58_off" data-id="58" data-set="PIP2346" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off58" style="top:401px;left:151.66668701171875px;"> PIP<sub>2</sub></div> <div id="el58_ct" class="pw-tooltip" data-id="58"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=PIP2">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el59_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray59 pw-gray" style="top:414px;left:67.66668701171875px;"> </div> <div id="el59_off" data-id="59" data-set="PIP3347" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off59" style="top:414px;left:67.66668701171875px;"> </div> <div id="el59_ct" class="pw-tooltip" data-id="59"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/inositol-lipid-antagonists">PIP3</a><br> </div> </div> <div id="el60_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray60 pw-gray" style="top:418.66668701171875px;left:89.66668701171875px;"> PIP<sub>3</sub> </div> <div id="el60_off" data-id="60" data-set="PIP3347" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off60" style="top:418.66668701171875px;left:89.66668701171875px;"> PIP<sub>3</sub></div> <div id="el60_ct" class="pw-tooltip" data-id="60"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/inositol-lipid-antagonists">PIP3</a><br> </div> </div> <div id="el61_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray61 pw-gray" style="top:444.66668701171875px;left:25.66668701171875px;"> </div> <div id="el61_off" data-id="61" data-set="PDK-1348" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off61" style="top:444.66668701171875px;left:25.66668701171875px;"> </div> <div id="el61_ct" class="pw-tooltip" data-id="61"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pdk-1">PDK-1</a><br> </div> </div> <div id="el62_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray62 pw-gray" style="top:452.3333435058594px;left:47.66668701171875px;"> PDK-1 </div> <div id="el62_off" data-id="62" data-set="PDK-1348" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off62" style="top:452.3333435058594px;left:47.66668701171875px;"> PDK-1</div> <div id="el62_ct" class="pw-tooltip" data-id="62"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pdk-1">PDK-1</a><br> </div> </div> <div id="el63_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray63 pw-gray" style="top:491.33333587646484px;left:6.66668701171875px;"> </div> <div id="el63_off" data-id="63" data-set="AktPKB349" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off63" style="top:491.33333587646484px;left:6.66668701171875px;"> </div> <div id="el63_ct" class="pw-tooltip" data-id="63"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/akt">Akt</a><br><a href="/target/akt1">Akt1</a><br><a href="/target/akt2">Akt2</a><br><a href="/target/akt3">Akt3</a><br> </div> </div> <div id="el64_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray64 pw-gray" style="top:496px;left:28.66668701171875px;"> Akt/PKB </div> <div id="el64_off" data-id="64" data-set="AktPKB349" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off64" style="top:496px;left:28.66668701171875px;"> Akt/PKB</div> <div id="el64_ct" class="pw-tooltip" data-id="64"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/akt">Akt</a><br><a href="/target/akt1">Akt1</a><br><a href="/target/akt2">Akt2</a><br><a href="/target/akt3">Akt3</a><br> </div> </div> <div id="el65_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label2 pw-center el-gray65 pw-gray" style="top:529.3333435058594px;left:21.5px;"> Cell Survival<br>Cell Proliferation </div> <div id="el65_off" data-id="65" data-set="CellSurvivalCellProliferation" data-type="" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label2 pw-center el-off65" style="top:529.3333435058594px;left:21.5px;"> Cell Survival<br>Cell Proliferation</div> <div id="el65_ct" class="pw-tooltip" data-id="65"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el66_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray66 pw-gray" style="top:581.3333358764648px;left:31.66668701171875px;"> </div> <div id="el66_off" data-id="66" data-set="TSC12Inactive351" data-type="" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off66" style="top:581.3333358764648px;left:31.66668701171875px;"> </div> <div id="el66_ct" class="pw-tooltip" data-id="66"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/tsc1">TSC1</a><br><a href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el67_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label pw-center el-gray67 pw-gray" style="top:578px;left:52px;"> TSC1/2<br>(Inactive) </div> <div id="el67_off" data-id="67" data-set="TSC12Inactive351" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label pw-center el-off67" style="top:578px;left:52px;"> TSC1/2<br>(Inactive)</div> <div id="el67_ct" class="pw-tooltip" data-id="67"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/tsc1">TSC1</a><br><a href="/target/tsc2">TSC2</a><br> </div> </div> <div id="el68_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray68 pw-gray" style="top:626px;left:30.66668701171875px;"> </div> <div id="el68_off" data-id="68" data-set="Rheb352" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off68" style="top:626px;left:30.66668701171875px;"> </div> <div id="el68_ct" class="pw-tooltip" data-id="68"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/rheb">Rheb</a><br> </div> </div> <div id="el69_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray69 pw-gray" style="top:628.6666717529297px;left:3.66668701171875px;"> Rheb </div> <div id="el69_off" data-id="69" data-set="Rheb352" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off69" style="top:628.6666717529297px;left:3.66668701171875px;"> Rheb</div> <div id="el69_ct" class="pw-tooltip" data-id="69"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/rheb">Rheb</a><br> </div> </div> <div id="el70_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray70 pw-gray" style="top:625.6666679382324px;left:41.66668701171875px;"> </div> <div id="el70_off" data-id="70" data-set="GTP353" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off70" style="top:625.6666679382324px;left:41.66668701171875px;"> </div> <div id="el70_ct" class="pw-tooltip" data-id="70"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el71_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray71 pw-gray" style="top:630.3333435058594px;left:62.66668701171875px;"> GTP </div> <div id="el71_off" data-id="71" data-set="GTP353" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off71" style="top:630.3333435058594px;left:62.66668701171875px;"> GTP</div> <div id="el71_ct" class="pw-tooltip" data-id="71"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> We currently do not offer products for this molecule<br><br>Use our <a target="_blank" href="/products/product-suggestions?m=GTP">Product Suggestion form</a> to enter a request.<br><br>You will be notified once it becomes available. </div> </div> <div id="el72_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray72 pw-gray" style="top:668.3333358764648px;left:50.66668701171875px;"> </div> <div id="el72_off" data-id="72" data-set="mTORC1354" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off72" style="top:668.3333358764648px;left:50.66668701171875px;"> </div> <div id="el72_ct" class="pw-tooltip" data-id="72"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/deptor-depdc6">DEPTOR</a><br><a href="/target/gbl">GBL</a><br><a href="/target/tor">mTOR</a><br><a href="/target/pras40">PRAS40</a><br><a href="/target/rptor">RPTOR</a><br> </div> </div> <div id="el73_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray73 pw-gray" style="top:671.6666717529297px;left:69.66668701171875px;"> mTORC1 </div> <div id="el73_off" data-id="73" data-set="mTORC1354" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off73" style="top:671.6666717529297px;left:69.66668701171875px;"> mTORC1</div> <div id="el73_ct" class="pw-tooltip" data-id="73"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/deptor-depdc6">DEPTOR</a><br><a href="/target/gbl">GBL</a><br><a href="/target/tor">mTOR</a><br><a href="/target/pras40">PRAS40</a><br><a href="/target/rptor">RPTOR</a><br> </div> </div> <div id="el74_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray74 pw-gray" style="top:699.6666870117188px;left:15.66668701171875px;"> </div> <div id="el74_off" data-id="74" data-set="p70S6Kinase355" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off74" style="top:699.6666870117188px;left:15.66668701171875px;"> </div> <div id="el74_ct" class="pw-tooltip" data-id="74"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/p70-s6-kinase">p70 S6 Kinase</a><br><a href="/target/p70-s6-kinase-beta">p70 S6 Kinase beta</a><br> </div> </div> <div id="el75_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray75 pw-gray" style="top:719.3333435058594px;left:4.66668701171875px;"> p70 S6K </div> <div id="el75_off" data-id="75" data-set="p70S6Kinase355" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off75" style="top:719.3333435058594px;left:4.66668701171875px;"> p70 S6K</div> <div id="el75_ct" class="pw-tooltip" data-id="75"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/p70-s6-kinase">p70 S6 Kinase</a><br><a href="/target/p70-s6-kinase-beta">p70 S6 Kinase beta</a><br> </div> </div> <div id="el76_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray76 pw-gray" style="top:751.3333435058594px;left:16.66668701171875px;"> </div> <div id="el76_off" data-id="76" data-set="RPS6356" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off76" style="top:751.3333435058594px;left:16.66668701171875px;"> </div> <div id="el76_ct" class="pw-tooltip" data-id="76"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el77_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray77 pw-gray" style="top:773px;left:7.66668701171875px;"> RPS6 </div> <div id="el77_off" data-id="77" data-set="RPS6356" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off77" style="top:773px;left:7.66668701171875px;"> RPS6</div> <div id="el77_ct" class="pw-tooltip" data-id="77"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/ribosomal-protein-s6-rps6">Ribosomal Protein S6</a><br> </div> </div> <div id="el78_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray78 pw-gray" style="top:699px;left:86.66668701171875px;"> </div> <div id="el78_off" data-id="78" data-set="4EBP1357" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off78" style="top:699px;left:86.66668701171875px;"> </div> <div id="el78_ct" class="pw-tooltip" data-id="78"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el79_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray79 pw-gray" style="top:701px;left:107px;"> 4EBP1 </div> <div id="el79_off" data-id="79" data-set="4EBP1357" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off79" style="top:701px;left:107px;"> 4EBP1</div> <div id="el79_ct" class="pw-tooltip" data-id="79"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el80_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray80 pw-gray" style="top:711.6666870117188px;left:86.66668701171875px;"> </div> <div id="el80_off" data-id="80" data-set="eIF4E358" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off80" style="top:711.6666870117188px;left:86.66668701171875px;"> </div> <div id="el80_ct" class="pw-tooltip" data-id="80"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el81_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray81 pw-gray" style="top:716.3333435058594px;left:108.66668701171875px;"> eIF4E </div> <div id="el81_off" data-id="81" data-set="eIF4E358" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off81" style="top:716.3333435058594px;left:108.66668701171875px;"> eIF4E</div> <div id="el81_ct" class="pw-tooltip" data-id="81"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el82_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray82 pw-gray" style="top:751.3333435058594px;left:57.66668701171875px;"> </div> <div id="el82_off" data-id="82" data-set="eIF4E359" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off82" style="top:751.3333435058594px;left:57.66668701171875px;"> </div> <div id="el82_ct" class="pw-tooltip" data-id="82"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el83_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray83 pw-gray" style="top:772px;left:51.66668701171875px;"> eIF4E </div> <div id="el83_off" data-id="83" data-set="eIF4E359" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off83" style="top:772px;left:51.66668701171875px;"> eIF4E</div> <div id="el83_ct" class="pw-tooltip" data-id="83"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/eif4e">eIF4E</a><br> </div> </div> <div id="el84_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray84 pw-gray" style="top:752px;left:119.66668701171875px;"> </div> <div id="el84_off" data-id="84" data-set="4EBP1360" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off84" style="top:752px;left:119.66668701171875px;"> </div> <div id="el84_ct" class="pw-tooltip" data-id="84"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el85_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray85 pw-gray" style="top:771.6666717529297px;left:114.66668701171875px;"> 4EBP1 </div> <div id="el85_off" data-id="85" data-set="4EBP1360" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off85" style="top:771.6666717529297px;left:114.66668701171875px;"> 4EBP1</div> <div id="el85_ct" class="pw-tooltip" data-id="85"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/4ebp1">4EBP1</a><br> </div> </div> <div id="el86_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label2 el-gray86 pw-gray" style="top:801px;left:21.2px;"> Protein Synthesis </div> <div id="el86_off" data-id="86" data-set="ProteinSynthesis" data-type="" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label2 el-off86" style="top:801px;left:21.2px;"> Protein Synthesis</div> <div id="el86_ct" class="pw-tooltip" data-id="86"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> </div> </div> <div id="el87_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray87 pw-gray" style="top:549.6666679382324px;left:271.66668701171875px;"> </div> <div id="el87_off" data-id="87" data-set="STAT1362" data-type="" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off87" style="top:549.6666679382324px;left:271.66668701171875px;"> </div> <div id="el87_ct" class="pw-tooltip" data-id="87"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br> </div> </div> <div id="el88_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray88 pw-gray" style="top:570px;left:264.66668701171875px;"> STAT1 </div> <div id="el88_off" data-id="88" data-set="STAT1362" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off88" style="top:570px;left:264.66668701171875px;"> STAT1</div> <div id="el88_ct" class="pw-tooltip" data-id="88"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br> </div> </div> <div id="el89_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray89 pw-gray" style="top:604px;left:335.66668701171875px;"> </div> <div id="el89_off" data-id="89" data-set="STAT3363" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off89" style="top:604px;left:335.66668701171875px;"> </div> <div id="el89_ct" class="pw-tooltip" data-id="89"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat3">STAT3</a><br> </div> </div> <div id="el90_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray90 pw-gray" style="top:624.3333435058594px;left:328.66668701171875px;"> STAT3 </div> <div id="el90_off" data-id="90" data-set="STAT3363" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off90" style="top:624.3333435058594px;left:328.66668701171875px;"> STAT3</div> <div id="el90_ct" class="pw-tooltip" data-id="90"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat3">STAT3</a><br> </div> </div> <div id="el91_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray91 pw-gray" style="top:538.3333435058594px;left:463.66668701171875px;"> </div> <div id="el91_off" data-id="91" data-set="STAT5364" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off91" style="top:538.3333435058594px;left:463.66668701171875px;"> </div> <div id="el91_ct" class="pw-tooltip" data-id="91"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el92_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray92 pw-gray" style="top:559.6666870117188px;left:456.66668701171875px;"> STAT5 </div> <div id="el92_off" data-id="92" data-set="STAT5364" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off92" style="top:559.6666870117188px;left:456.66668701171875px;"> STAT5</div> <div id="el92_ct" class="pw-tooltip" data-id="92"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el93_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray93 pw-gray" style="top:665.6666870117188px;left:327.66668701171875px;"> </div> <div id="el93_off" data-id="93" data-set="STATDimer365" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off93" style="top:665.6666870117188px;left:327.66668701171875px;"> </div> <div id="el93_ct" class="pw-tooltip" data-id="93"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br><a href="/target/stat3">STAT3</a><br><a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el94_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray94 pw-gray" style="top:687px;left:310.66668701171875px;"> STAT Dimer </div> <div id="el94_off" data-id="94" data-set="STATDimer365" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off94" style="top:687px;left:310.66668701171875px;"> STAT Dimer</div> <div id="el94_ct" class="pw-tooltip" data-id="94"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br><a href="/target/stat3">STAT3</a><br><a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el95_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray95 pw-gray" style="top:836px;left:327.66668701171875px;"> </div> <div id="el95_off" data-id="95" data-set="STATDimer366" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off95" style="top:836px;left:327.66668701171875px;"> </div> <div id="el95_ct" class="pw-tooltip" data-id="95"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br><a href="/target/stat3">STAT3</a><br><a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el96_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray96 pw-gray" style="top:827.3333435058594px;left:314.66668701171875px;"> STAT Dimer </div> <div id="el96_off" data-id="96" data-set="STATDimer366" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-27p28_il-30 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off96" style="top:827.3333435058594px;left:314.66668701171875px;"> STAT Dimer</div> <div id="el96_ct" class="pw-tooltip" data-id="96"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/stat1">STAT1</a><br><a href="/target/stat3">STAT3</a><br><a href="/target/stat5a">STAT5a</a><br><a href="/target/stat5a-b">STAT5a/b</a><br><a href="/target/stat5b">STAT5b</a><br> </div> </div> <div id="el97_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray97 pw-gray" style="top:483.3333435058594px;left:535.666748046875px;"> </div> <div id="el97_off" data-id="97" data-set="SHP-2orSHC367" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off97" style="top:483.3333435058594px;left:535.666748046875px;"> </div> <div id="el97_ct" class="pw-tooltip" data-id="97"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/shp-2">SHP-2</a><br><a href="/target/shc1">SHC1</a><br> </div> </div> <div id="el98_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray98 pw-gray" style="top:489px;left:446.66668701171875px;"> SHP-2 or SHC </div> <div id="el98_off" data-id="98" data-set="SHP-2orSHC367" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off98" style="top:489px;left:446.66668701171875px;"> SHP-2 or SHC</div> <div id="el98_ct" class="pw-tooltip" data-id="98"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/shp-2">SHP-2</a><br><a href="/target/shc1">SHC1</a><br> </div> </div> <div id="el99_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray99 pw-gray" style="top:494px;left:538.666748046875px;"> </div> <div id="el99_off" data-id="99" data-set="Grb2368" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off99" style="top:494px;left:538.666748046875px;"> </div> <div id="el99_ct" class="pw-tooltip" data-id="99"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/grb2">GRB2</a><br> </div> </div> <div id="el100_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray100 pw-gray" style="top:502.66668701171875px;left:514.666748046875px;"> Grb2 </div> <div id="el100_off" data-id="100" data-set="Grb2368" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off100" style="top:502.66668701171875px;left:514.666748046875px;"> Grb2</div> <div id="el100_ct" class="pw-tooltip" data-id="100"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/grb2">GRB2</a><br> </div> </div> <div id="el101_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray101 pw-gray" style="top:506.66668701171875px;left:540.666748046875px;"> </div> <div id="el101_off" data-id="101" data-set="SOS369" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off101" style="top:506.66668701171875px;left:540.666748046875px;"> </div> <div id="el101_ct" class="pw-tooltip" data-id="101"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/sos2">SOS2</a><br> </div> </div> <div id="el102_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray102 pw-gray" style="top:511.3333435058594px;left:560.666748046875px;"> SOS </div> <div id="el102_off" data-id="102" data-set="SOS369" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off102" style="top:511.3333435058594px;left:560.666748046875px;"> SOS</div> <div id="el102_ct" class="pw-tooltip" data-id="102"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/sos2">SOS2</a><br> </div> </div> <div id="el103_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-gray103 pw-gray" style="top:483.3333435058594px;left:546.666748046875px;"> </div> <div id="el103_off" data-id="103" data-set="Gab12370" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-sprite el-off103" style="top:483.3333435058594px;left:546.666748046875px;"> </div> <div id="el103_ct" class="pw-tooltip" data-id="103"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/gab2">GAB2</a><br> </div> </div> <div id="el104_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-gray104 pw-gray" style="top:486px;left:568.666748046875px;"> Gab1/2 </div> <div id="el104_off" data-id="104" data-set="Gab12370" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 il-6family_neuropoietin pw-label el-off104" style="top:486px;left:568.666748046875px;"> Gab1/2</div> <div id="el104_ct" class="pw-tooltip" data-id="104"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/gab2">GAB2</a><br> </div> </div> <div id="el105_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray105 pw-gray" style="top:591.6666679382324px;left:513.666748046875px;"> </div> <div id="el105_off" data-id="105" data-set="Vav371" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off105" style="top:591.6666679382324px;left:513.666748046875px;"> </div> <div id="el105_ct" class="pw-tooltip" data-id="105"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/vav-1">Vav-1</a><br> </div> </div> <div id="el106_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray106 pw-gray" style="top:596px;left:493.666748046875px;"> Vav </div> <div id="el106_off" data-id="106" data-set="Vav371" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off106" style="top:596px;left:493.666748046875px;"> Vav</div> <div id="el106_ct" class="pw-tooltip" data-id="106"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/vav-1">Vav-1</a><br> </div> </div> <div id="el107_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray107 pw-gray" style="top:629px;left:514.666748046875px;"> </div> <div id="el107_off" data-id="107" data-set="Rac1372" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off107" style="top:629px;left:514.666748046875px;"> </div> <div id="el107_ct" class="pw-tooltip" data-id="107"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/rac1">Rac1</a><br> </div> </div> <div id="el108_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray108 pw-gray" style="top:628.3333358764648px;left:486.666748046875px;"> Rac1 </div> <div id="el108_off" data-id="108" data-set="Rac1372" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off108" style="top:628.3333358764648px;left:486.666748046875px;"> Rac1</div> <div id="el108_ct" class="pw-tooltip" data-id="108"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/rac1">Rac1</a><br> </div> </div> <div id="el109_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray109 pw-gray" style="top:663.3333740234375px;left:488.666748046875px;"> </div> <div id="el109_off" data-id="109" data-set="MAPKKKUnknown373" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off109" style="top:663.3333740234375px;left:488.666748046875px;"> </div> <div id="el109_ct" class="pw-tooltip" data-id="109"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/mekk2">MEKK2</a><br><a href="/target/mekk3">MEKK3</a><br><a href="/target/tak1">TAK1</a><br> </div> </div> <div id="el110_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label pw-center el-gray110 pw-gray" style="top:646.6667175292969px;left:426px;"> MAPKKK<br>(Unknown) </div> <div id="el110_off" data-id="110" data-set="MAPKKKUnknown373" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label pw-center el-off110" style="top:646.6667175292969px;left:426px;"> MAPKKK<br>(Unknown)</div> <div id="el110_ct" class="pw-tooltip" data-id="110"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/mekk2">MEKK2</a><br><a href="/target/mekk3">MEKK3</a><br><a href="/target/tak1">TAK1</a><br> </div> </div> <div id="el111_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray111 pw-gray" style="top:683.6666870117188px;left:448px;"> </div> <div id="el111_off" data-id="111" data-set="MKK4374" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off111" style="top:683.6666870117188px;left:448px;"> </div> <div id="el111_ct" class="pw-tooltip" data-id="111"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/mkk4">MKK4</a><br> </div> </div> <div id="el112_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray112 pw-gray" style="top:685.6666870117188px;left:409px;"> MKK-4 </div> <div id="el112_off" data-id="112" data-set="MKK4374" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off112" style="top:685.6666870117188px;left:409px;"> MKK-4</div> <div id="el112_ct" class="pw-tooltip" data-id="112"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/mkk4">MKK4</a><br> </div> </div> <div id="el113_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray113 pw-gray" style="top:731.6666870117188px;left:404px;"> </div> <div id="el113_off" data-id="113" data-set="p38375" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off113" style="top:731.6666870117188px;left:404px;"> </div> <div id="el113_ct" class="pw-tooltip" data-id="113"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/p38">p38</a><br><a href="/target/p38-alpha">p38 alpha</a><br><a href="/target/p38-beta-mapk11">p38 beta</a><br><a href="/target/p38-gamma">p38 gamma</a><br><a href="/target/p38-delta">p38 delta</a><br><a href="/target/p38-inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el114_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray114 pw-gray" style="top:752.6666870117188px;left:403px;"> p38 </div> <div id="el114_off" data-id="114" data-set="p38375" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off114" style="top:752.6666870117188px;left:403px;"> p38</div> <div id="el114_ct" class="pw-tooltip" data-id="114"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/p38">p38</a><br><a href="/target/p38-alpha">p38 alpha</a><br><a href="/target/p38-beta-mapk11">p38 beta</a><br><a href="/target/p38-gamma">p38 gamma</a><br><a href="/target/p38-delta">p38 delta</a><br><a href="/target/p38-inhibitors">p38 Inhibitors</a><br> </div> </div> <div id="el115_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray115 pw-gray" style="top:730.6666870117188px;left:449px;"> </div> <div id="el115_off" data-id="115" data-set="JNK376" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off115" style="top:730.6666870117188px;left:449px;"> </div> <div id="el115_ct" class="pw-tooltip" data-id="115"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/jnk">JNK</a><br><a href="/target/jnk1">JNK1</a><br><a href="/target/jnk1-jnk2">JNK1/JNK2</a><br><a href="/target/jnk3">JNK3</a><br> </div> </div> <div id="el116_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray116 pw-gray" style="top:751.6666870117188px;left:447px;"> JNK </div> <div id="el116_off" data-id="116" data-set="JNK376" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off116" style="top:751.6666870117188px;left:447px;"> JNK</div> <div id="el116_ct" class="pw-tooltip" data-id="116"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/jnk">JNK</a><br><a href="/target/jnk1">JNK1</a><br><a href="/target/jnk1-jnk2">JNK1/JNK2</a><br><a href="/target/jnk3">JNK3</a><br> </div> </div> <div id="el117_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray117 pw-gray" style="top:731px;left:495.666748046875px;"> </div> <div id="el117_off" data-id="117" data-set="PKCdelta377" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off117" style="top:731px;left:495.666748046875px;"> </div> <div id="el117_ct" class="pw-tooltip" data-id="117"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pkc-delta">PKC delta</a><br> </div> </div> <div id="el118_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray118 pw-gray" style="top:751.3333435058594px;left:493.666748046875px;"> PKC delta </div> <div id="el118_off" data-id="118" data-set="PKCdelta377" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off118" style="top:751.3333435058594px;left:493.666748046875px;"> PKC delta</div> <div id="el118_ct" class="pw-tooltip" data-id="118"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/pkc-delta">PKC delta</a><br> </div> </div> <div id="el119_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-gray119 pw-gray" style="top:835.3333435058594px;left:458.66668701171875px;"> </div> <div id="el119_off" data-id="119" data-set="AP-1378" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-sprite el-off119" style="top:835.3333435058594px;left:458.66668701171875px;"> </div> <div id="el119_ct" class="pw-tooltip" data-id="119"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/atf2">ATF2</a><br><a href="/target/c-jun">c-Jun</a><br><a href="/target/c-fos">c-Fos</a><br><a href="/target/junb">JunB</a><br><a href="/target/jund">JunD</a><br><a href="/target/fosb-g0s3">FosB/G0S3</a><br><a href="/target/fra-1">Fra-1</a><br> </div> </div> <div id="el120_gry" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-gray120 pw-gray" style="top:826.6666870117188px;left:461.66668701171875px;"> AP-1 </div> <div id="el120_off" data-id="120" data-set="AP-1378" data-type="No Products Click" class="il-6family_il-6 il-6family_il-11 il-6family_il-31 il-6family_lif il-6family_osm il-6family_clc il-6family_cntf il-6family_ct-1 pw-label el-off120" style="top:826.6666870117188px;left:461.66668701171875px;"> AP-1</div> <div id="el120_ct" class="pw-tooltip" data-id="120"> <div class="pw-tooltip-head">Products<a href="#">Close</a></div> <div class="pw-tooltip-inner"> <a href="/target/atf2">ATF2</a><br><a href="/target/c-jun">c-Jun</a><br><a 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src="https://resources.rndsystems.com/images/Pathways/pathway-images/osm-static.png?t=3" alt="Oncostatin M Signaling Pathways" style="height:912px"> </div> </div> <div id="pathway-description"><p><h2>Overview of Oncostatin M (OSM) Signaling Pathways</h2> <p>Oncostatin M (OSM) is a member of the IL-6 cytokine family, which also includes IL-6, IL-11, IL-27 p28/IL-30, IL-31, Leukemia inhibitory factor (LIF), Cardiotrophin-like cytokine (CLC), Ciliary neurotrophic factor (CNTF), Cardiotrophin-1 (CT-1), and Neuropoietin. OSM is produced primarily by activated monocytes and macrophages, activated T cells, dendritic cells, neutrophils, and osteoblasts. Like other IL-6 family cytokines, OSM is a long chain four alpha-helix bundle cytokine with up-up-down-down topology, but it is unique in that it can signal through two different receptor complexes. The type I OSM receptor complex consists of LIF R and gp130, while the type II OSM receptor complex consists of OSM R and gp130. OSM initially binds with low affinity to gp130 and then recruits either LIF R or OSM R. LIF R, OSM R, and gp130 all associate with members of the Jak family of tyrosine kinases through their cytoplasmic domains, leading to the phosphorylation, dimerization, and nuclear translocation of STAT family proteins, predominantly STAT3, STAT5, and STAT1. In addition, OSM signaling triggers activation of the Ras-MAPK pathway, the PI 3-K-Akt pathway, the p38 and JNK MAPK pathways, and PKC delta.</p> <p>OSM was originally discovered as a cytokine capable of inhibiting the growth of melanoma cells and has subsequently been found to have a wide range of effects on different cell types. It has been shown to regulate the formation and maintenance of the bone marrow niche required for hematopoiesis, to suppress adipocyte differentiation and promote osteoblast differentiation of mesenchymal stem cells, and to regulate inflammatory responses. OSM is capable of both promoting and inhibiting inflammation depending on the target cell and the other cytokines present in the microenvironment. In the liver, OSM was found to regulate the acute phase response, as well as hepatocyte proliferation and tissue remodeling during liver regeneration. Additionally, OSM has been shown to regulate the development of the central nervous system, induce the dedifferentiation of cardiomyocytes, regulate the production of other cytokines and growth factors by endothelial cells, and stimulate angiogenesis.</p> <p>To learn more, please visit our <a href="/research-area/il--6-family">IL-6 Family Research Area page</a>.</p> <table cellpadding="1" cellspacing="1" class="border" width="100%"> <tbody> <tr> <td class="blue_high">Primary OSM-Expressing Cells</td> <td class="blue_high">Primary Biological Effects of OSM</td> </tr> <tr> <td>Activated monocytes/macrophages</td> <td>Regulates the formation and maintenance of the hematopoietic microenvironment</td> </tr> <tr> <td>Activated T cells</td> <td>Regulates mesenchymal stem cell differentiation; Suppresses adipocyte differentiation</td> </tr> <tr> <td>Dendritic cells</td> <td>Regulates hepatocyte proliferation and tissue remodeling during liver regeneration; Regulates the acute phase response</td> </tr> <tr> <td>Neutrophils</td> <td>Induces cardiomyocyte dedifferentiation</td> </tr> <tr> <td>Osteoblasts</td> <td>Regulates bone formation and resorption</td> </tr> <tr> <td> </td> <td>Neuroregulatory</td> </tr> <tr> <td> </td> <td>Regulates the development of nociceptive neurons in the dorsal root ganglia</td> </tr> <tr> <td> </td> <td>Regulates inflammatory responses</td> </tr> <tr> <td> </td> <td>Regulates the production of other cytokines and growth factors by endothelial cells; Stimulates angiogenesis</td> </tr> </tbody> </table></p></div> <div id="print-copy-form" class="accordion-wrapper"> <h3 class="builder-header builder-bead-type ui-accordion-header ui-helper-reset ui-state-default ui-corner-all ui-accordion-icons" data-toggle="collapse" data-target="#collapsePathwayRequest" aria-expanded="false" id="pathwayRequestAccordionHeader"> <span class="ui-accordion-header-icon" id="accordionArrow"></span> Get Print Copy of this Pathway </h3> <div class="collapse" 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