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This quest for going with adjuvants has brought about a large number of atoms... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_81998632" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">With the onset of antigen creation utilizing biosynthetic and rDNA strategies, the need to manage adjuvants alongside immunizations has expanded astoundingly. This quest for going with adjuvants has brought about a large number of atoms from mineral salts to bacterial polysaccharides and Immuno stimulatory edifices that extent significantly in viability. In addition, the adjuvant particle is particular to its antigen atom and henceforth must be custom-made appropriately to boost adequacy and security, keeping up the expense at the very least. This paper investigates the attributes of these particles, their method of activity and the headways in the field.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/81998632" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6fb1cf635d334b315315b5f52ee2fcef" rel="nofollow" data-download="{"attachment_id":87846452,"asset_id":81998632,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/87846452/download_file?st=MTc0MTEwNTI4Nyw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2464654" href="https://jntua.academia.edu/DivyaAnumakonda">Divya Anumakonda</a><script data-card-contents-for-user="2464654" type="text/json">{"id":2464654,"first_name":"Divya","last_name":"Anumakonda","domain_name":"jntua","page_name":"DivyaAnumakonda","display_name":"Divya Anumakonda","profile_url":"https://jntua.academia.edu/DivyaAnumakonda","photo":"https://0.academia-photos.com/2464654/771280/958661/s65_divya.anumakonda.gif"}</script></span></span></li><li class="js-paper-rank-work_81998632 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="81998632"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 81998632, container: ".js-paper-rank-work_81998632", }); 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This quest for going with adjuvants has brought about a large number of atoms... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_86870787" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">With the onset of antigen creation utilizing biosynthetic and rDNA strategies, the need to manage adjuvants alongside immunizations has expanded astoundingly. This quest for going with adjuvants has brought about a large number of atoms from mineral salts to bacterial polysaccharides and Immuno stimulatory edifices that extent significantly in viability. In addition, the adjuvant particle is particular to its antigen atom and henceforth must be custom-made appropriately to boost adequacy and security, keeping up the expense at the very least. This paper investigates the attributes of these particles, their method of activity and the headways in the field.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/86870787" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="500b4681bffb8ff5ac32e08913caa43b" rel="nofollow" data-download="{"attachment_id":91229121,"asset_id":86870787,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/91229121/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="2464654" href="https://jntua.academia.edu/DivyaAnumakonda">Divya Anumakonda</a><script data-card-contents-for-user="2464654" type="text/json">{"id":2464654,"first_name":"Divya","last_name":"Anumakonda","domain_name":"jntua","page_name":"DivyaAnumakonda","display_name":"Divya Anumakonda","profile_url":"https://jntua.academia.edu/DivyaAnumakonda","photo":"https://0.academia-photos.com/2464654/771280/958661/s65_divya.anumakonda.gif"}</script></span></span></li><li class="js-paper-rank-work_86870787 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="86870787"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 86870787, container: ".js-paper-rank-work_86870787", }); 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This quest for going with adjuvants has brought about a large number of atoms from mineral salts to bacterial polysaccharides and Immuno stimulatory edifices that extent significantly in viability. In addition, the adjuvant particle is particular to its antigen atom and henceforth must be custom-made appropriately to boost adequacy and security, keeping up the expense at the very least. This paper investigates the attributes of these particles, their method of activity and the headways in the field.","publication":"Research and reviews: journal of medical and health sciences","publication_with_fallback":"Research and reviews: journal of medical and health sciences","downloadable_attachments":[{"id":91229121,"asset_id":86870787,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/91229121/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/91229121/immunologic-adjuvants--an-overview--libre.pdf?1663553900=\u0026response-content-disposition=attachment%3B+filename%3DImmunologic_Adjuvants_A_AA_An_Overview.pdf\u0026Expires=1741108887\u0026Signature=FBAGbfsuEq~KdNs~-va4n1OmofjUcynZ9Fhc4rM7XvQZjCqWq2xRx6x5tGJ8Ct-btgU0Ktdl4Md5rPb4X--wjTPeB6iCKEKW3YHuqkJsW1xOBACs7UmC~tQQb8Sc3LTsNbAm7Yy~J8SRvKC1-8ynWGnR4Xewex43vx~BYnt5~P9Vsd8tIkNZe1w8k9GXieWSSBvEYcGJL~n~tGi3g9a-PjTFNyR9H1f6~nMbjUWERdn4t4qT3-hn5UnFdVdhY-knArCw5SIFLKvTh1VuP2dfSjGL~feyXy438cddOtxJ4AEQnVd7xronNFi3KG4eePAHk3e1Kt294gjz06LPkid7eg__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/91229121/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/91229121/mini_magick20220919-1-1o63nb6.png?1663551542"}],"downloadable_attachments_with_full_thumbnails":[{"id":91229121,"asset_id":86870787,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/91229121/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/91229121/immunologic-adjuvants--an-overview--libre.pdf?1663553900=\u0026response-content-disposition=attachment%3B+filename%3DImmunologic_Adjuvants_A_AA_An_Overview.pdf\u0026Expires=1741108888\u0026Signature=MTG1cXkMfpucG-zD8rzr5fuvIwIVKQqBvWiFe0SophfQQbkKpksUjtOEi9gUv4fKb8wK6uMy2fBVxGsRdlvD76PrNVKNVf5vDRzVXgIQodidsqOJUh8aSOYuzchz1ePfFGt6CLVdFHal0Dlj-~B8BxjOlqCQpEOUEDVqR4NE7dfwLOLQNyLUGRACEbz6oCAkYau3LsShTaIFqHxEtJYQLNKDtoInpjmExmkQvZkWnZhdKyec1PbJVINASINSWO-ObFPgMycPTzdI~bL5LLNpHx1Lhl3RKnlAx9DmGoKTfBxyFQcdawG7drFyKER5rskcMcCwNncXVD-F-HhOF~Tg-g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/91229121/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/91229121/mini_magick20220919-1-1o63nb6.png?1663551542"}],"has_pdf":true,"has_fulltext":true,"page_count":8,"ordered_authors":[{"id":2464654,"first_name":"Divya","last_name":"Anumakonda","domain_name":"jntua","page_name":"DivyaAnumakonda","display_name":"Divya Anumakonda","profile_url":"https://jntua.academia.edu/DivyaAnumakonda","photo":"https://0.academia-photos.com/2464654/771280/958661/s65_divya.anumakonda.gif"}],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine","nofollow":true},{"id":1485245,"name":"Adjuvant","url":"https://www.academia.edu/Documents/in/Adjuvant","nofollow":true}],"publication_year":2014,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":15,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_6740448" data-work_id="6740448" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/6740448/Assessment_of_Hupu_Gum_for_Its_Carrier_Property_in_the_Design_and_Evaluation_of_Solid_Mixtures_of_Poorly_Water_Soluble_Drug_Rofecoxib">Assessment of Hupu Gum for Its Carrier Property in the Design and Evaluation of Solid Mixtures of Poorly Water Soluble Drug -Rofecoxib</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">There are no reports about the pharmaceutical applications of hupu gum (HG). Hence the present study was undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken as model... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_6740448" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">There are no reports about the pharmaceutical applications of hupu gum (HG). Hence the present study was undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken as model drug. For comparison solid mixtures were prepared with carriers such as poly vinyl pyrrolidone (PVP), sodium starch glycollate (SSG) and guar gum (GG). Physical mixing (PM), co-grinding (CG), kneading (KT) and solvent evaporation (SE) techniques were used to prepare the solid mixtures, using all the carriers in different carrier and drug ratios. The solid mixtures were characterized by powder X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy (FTIR). There was a significant improvement in the dissolution rate of solid mixtures of HG, when compared with the solid mixtures of other carriers. There was an increase in dissolution rate with increase in concentration of HG upto 1:1 ratio of carrier and drug. No drug-carrier interaction was found by FTIR studies. XRD studies indicated reduction in crystallinity of the drug with increase in HG concentration. Hence HG could be a useful carrier for the dissolution enhancement of poorly water soluble drugs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/6740448" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="35bdf145ca873b66ddd5f92e2957baf3" rel="nofollow" data-download="{"attachment_id":33455664,"asset_id":6740448,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/33455664/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_6740448 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="6740448"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 6740448, container: ".js-paper-rank-work_6740448", }); 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Hence the present study was undertaken to test its suitability in the dissolution enhancement of poorly water soluble drug. Rofecoxib (RFB) was taken as model drug. For comparison solid mixtures were prepared with carriers such as poly vinyl pyrrolidone (PVP), sodium starch glycollate (SSG) and guar gum (GG). Physical mixing (PM), co-grinding (CG), kneading (KT) and solvent evaporation (SE) techniques were used to prepare the solid mixtures, using all the carriers in different carrier and drug ratios. The solid mixtures were characterized by powder X-ray diffraction (XRD) and Fourier-transformed infrared spectroscopy (FTIR). There was a significant improvement in the dissolution rate of solid mixtures of HG, when compared with the solid mixtures of other carriers. There was an increase in dissolution rate with increase in concentration of HG upto 1:1 ratio of carrier and drug. No drug-carrier interaction was found by FTIR studies. XRD studies indicated reduction in crystallinity of the drug with increase in HG concentration. Hence HG could be a useful carrier for the dissolution enhancement of poorly water soluble drugs.","publication":null,"publication_with_fallback":null,"downloadable_attachments":[{"id":33455664,"asset_id":6740448,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/33455664/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/33455664/RFB-HG-CDD.pdf?1738111565=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_Hupu_Gum_for_Its_Carrier_P.pdf\u0026Expires=1741108888\u0026Signature=MUUvgTBPRWZyFIyWDG34~TgPKnKTb8BoQWWnaEph2jjA589hMfNs9tgGzwm1wlQvM42JLTIyh3kDcUWFNzfkh3QgIUFEIWlGtZoQBqGw5puYs1dFQscwQI9mrtamg3IAnPe3XeXPD~z2hGInXZXugBojtVQC2OTeB8p9ndEutlzCY-50Z9QqkaD752rGKR~IkpZ6-nuaLVOx0wqDS~4oVeXORqgWxRvqsdfOAZslv2hPJJCiHpDJYgO5RMP2m9mjL3XAw3aq86VS0XPfRCfxMm75zXbAtYfGGHZ9AHPkugEzKqUM5qq9fAtvQyFk5vcJahUKqI2zSDoQgrmmLyq2wA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/33455664/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/33455664/mini_magick20220708-14201-xp0do2.png?1657270555"}],"downloadable_attachments_with_full_thumbnails":[{"id":33455664,"asset_id":6740448,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/33455664/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/33455664/RFB-HG-CDD.pdf?1738111565=\u0026response-content-disposition=attachment%3B+filename%3DAssessment_of_Hupu_Gum_for_Its_Carrier_P.pdf\u0026Expires=1741108888\u0026Signature=MUUvgTBPRWZyFIyWDG34~TgPKnKTb8BoQWWnaEph2jjA589hMfNs9tgGzwm1wlQvM42JLTIyh3kDcUWFNzfkh3QgIUFEIWlGtZoQBqGw5puYs1dFQscwQI9mrtamg3IAnPe3XeXPD~z2hGInXZXugBojtVQC2OTeB8p9ndEutlzCY-50Z9QqkaD752rGKR~IkpZ6-nuaLVOx0wqDS~4oVeXORqgWxRvqsdfOAZslv2hPJJCiHpDJYgO5RMP2m9mjL3XAw3aq86VS0XPfRCfxMm75zXbAtYfGGHZ9AHPkugEzKqUM5qq9fAtvQyFk5vcJahUKqI2zSDoQgrmmLyq2wA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/33455664/download_file?st=MTc0MTEwNTI4OCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/33455664/mini_magick20220708-14201-xp0do2.png?1657270555"}],"has_pdf":true,"has_fulltext":true,"page_count":10,"ordered_authors":[{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology","nofollow":true},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true},{"id":205584,"name":"Solubility","url":"https://www.academia.edu/Documents/in/Solubility","nofollow":true},{"id":448628,"name":"Drug release kinetics","url":"https://www.academia.edu/Documents/in/Drug_release_kinetics","nofollow":true},{"id":773202,"name":"NOVEL DRUG DELIVERY SYSTEM","url":"https://www.academia.edu/Documents/in/NOVEL_DRUG_DELIVERY_SYSTEM"},{"id":1109503,"name":"Carriers","url":"https://www.academia.edu/Documents/in/Carriers"}],"publication_year":null,"publication_year_with_fallback":null,"paper_rank":null,"all_time_views":218,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_16196649 coauthored" data-work_id="16196649" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/16196649/Solid_self_microemulsification_of_Atorvastatin_using_hydrophilic_carriers_a_design">Solid self microemulsification of Atorvastatin using hydrophilic carriers: a design</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Context: Atorvastatin has a limited advantage to formulate oral dosage forms. Objective: To enhance the solubility of Atorvastatin and to design the suitable solid self-microemulsifying drug delivery systems (S-SMEDDS) Materials and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_16196649" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Context: Atorvastatin has a limited advantage to formulate oral dosage forms.<br />Objective: To enhance the solubility of Atorvastatin and to design the suitable solid<br />self-microemulsifying drug delivery systems (S-SMEDDS)<br />Materials and methods: The clear and transparent self-microemulsifying drug delivery system<br />(SMEDDS) were formulated using coconut oil and isopropyl myristate as lipid phases; Tween 80<br />as surfactant; PEG 400 and glycerin as co-surfactant at 2:1, 3:1, 1:2 and 1:3 ratio. The pseudo<br />ternary phase diagrams were constructed to identify the microemulsion region. The SMEDDS<br />were evaluated for zeta potential, poly dispersity index, globule size, pH, viscosity and drug<br />release. The solid SMEDDS were developed by employing adsorption and melt granulation<br />methods. The S-SMEDDS were evaluated for micromeritics, morphology, solid state property,<br />reconstitution ability, drug release and stability.<br />Results: The micro formulations formed with particle size of 25nm had shown a 3-folds rise in<br />drug release. The solid SMEDDS had reconstituted to a good microemulsion rapidly in 1–3 min,<br />with a release of 94.62% at the end of 30 min and behaved as immediate releasing capsules.<br />Their shelf-life was found to be 1.3 years.<br />Discussion: The 1:3 ratio SMEDDS had shown more drug release owing to their less particle size.<br />The solid SMEDDS had shown an increased dissolution profiles than atorvastatin. The solid state<br />of the drug had changed in formulation inferring their enhanced solubility.<br />Conclusion: The solid form of atorvastatin liquid SMEDDS had been formulated successfully with<br />enhanced shelf life and solubility.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/16196649" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="1106db8808360e3d2a6de849d45fc6f2" rel="nofollow" data-download="{"attachment_id":38897154,"asset_id":16196649,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/38897154/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-16196649">+4</span><div class="hidden js-additional-users-16196649"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://rguhs.academia.edu/HariniVadlamudi">Harini Chowdary Vadlamudi</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://svce.academia.edu/JasminIsmail">Jasmin Ismail</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/VandanaR">Vandana R</a></span></div><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/RNandaKishore">R Nanda Kishore</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-16196649'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-16196649').html(); } } new HoverPopover(popoverSettings); })();</script></li><li class="js-paper-rank-work_16196649 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="16196649"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 16196649, container: ".js-paper-rank-work_16196649", }); });</script></li><li class="js-percentile-work_16196649 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 16196649; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_16196649"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_16196649 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="16196649"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 16196649; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=16196649]").text(description); $(".js-view-count-work_16196649").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_16196649").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21205096" data-work_id="21205096" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21205096/In_vitro_Dynamics_of_Ibuprofen_Incorporated_Proniosomal_Gel">In vitro Dynamics of Ibuprofen Incorporated Proniosomal Gel</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The research was aimed to encapsulate the ibuprofen with proniosomal gel and facilitate ibuprofen release in sustained manner for sustained drug release. Methods: Different proniosomal gels of ibuprofen were formulated with Span 20/Span... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21205096" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The research was aimed to encapsulate the ibuprofen with proniosomal gel and facilitate ibuprofen release in sustained manner for sustained drug release. Methods: Different proniosomal gels of ibuprofen were formulated with Span 20/Span 80 and soya lecithin using the method described in literature. In all formulations cholesterol concentration was kept constant. The prepared proniosomal gels were evaluated for chemical incompatibility by FT-IR, vesicle size analysis, encapsulation efficiency, in vitro drug permeation and in vitro drug release kinetics were performed. Results: The principal absorption peaks of ibuprofen were retained in the proniosomal gels indicating that there was no interaction between ibuprofen and excipients. Vesicular diameter markedly depended on the type of the non-ionic surfactant used. As the outer diameter depends on the HLB value of surfactant, the vesicular diameter was less for proniosomes prepared using Span 80 (low HLB). The encapsulation efficiency was more for the proniosomal gels prepared using Span 20. Proniosomal gel prepared using Span 80 showed higher flux across the membrane due to its leaky membrane. The order of ibuprofen release from the proniosomal gel was PN2>PN4>PN1>PN3. Conclusion: The optimized proniosomal gel formulation PN3 containing Span 20 exhibited prolonged ibuprofen release profiles. Fickian diffusion mechanism was observed with the PN3 formulation which was due to the sustained release property. The results indicated that the proniosomal gel would be an effective transdermal delivery system for ibuprofen.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21205096" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="76dc2c9089f664e7fb176dce5f5a43c6" rel="nofollow" data-download="{"attachment_id":54183152,"asset_id":21205096,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183152/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21205096 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21205096"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21205096, container: ".js-paper-rank-work_21205096", }); });</script></li><li class="js-percentile-work_21205096 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205096; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21205096"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21205096 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21205096"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205096; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205096]").text(description); $(".js-view-count-work_21205096").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21205096").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21205097" data-work_id="21205097" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21205097/An_overview_on_in_situ_micronization_technique_An_emerging_novel_concept_in_advanced_drug_delivery">An overview on in situ micronization technique – An emerging novel concept in advanced drug delivery</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21205097" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The use of drug powders containing micronized drug particles has been increasing in several pharmaceutical dosage forms to overcome the dissolution and bioavailability problems. Most of the newly developed drugs are poorly water soluble which limits dissolution rate and bioavailability. The dissolution rate can be enhanced by micronization of the drug particles. The properties of the micronized drug substance such as particle size, size distribution, shape, surface properties, and agglomeration behaviour and powder flow are affected by the type of micronization technique used. Mechanical communition, spray drying and supercritical fluid (SCF) technology are the most commonly employed techniques for production of micronized drug particles but the characteristics of the resulting drug product cannot be controlled using these techniques. Hence, a newer technique called in situ micronization is developed in order to overcome the limitations associated with the other techniques. This review summarizes the existing knowledge on in situ micronization techniques. The properties of the resulting drug substance obtained by in situ micronization were also compared.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21205097" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="2a2d99a0bb9806ff2db015903ece4f05" rel="nofollow" data-download="{"attachment_id":54183168,"asset_id":21205097,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183168/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21205097 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21205097"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21205097, container: ".js-paper-rank-work_21205097", }); });</script></li><li class="js-percentile-work_21205097 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205097; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21205097"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21205097 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21205097"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205097; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205097]").text(description); $(".js-view-count-work_21205097").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21205097").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21205099" data-work_id="21205099" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21205099/Formulation_and_evaluation_of_chitosan_solid_lipid_nanoparticles_of_carbamazepine">Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The present work aims at preparing aqueous suspension of Solid lipid Nanoparticles containing Chitosan (CT) which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Carbamezapine (CBZ)... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21205099" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The present work aims at preparing aqueous suspension of Solid lipid Nanoparticles containing Chitosan (CT) which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Carbamezapine (CBZ) is a lipophilic drug which shows it antiepileptic activity by inactivating sodium channels. The solid lipid Nanoparticles (SLN) of Chitosan-CBZ were prepared by using solvent injection method using ethanol as organic solvent. The prepared SLN formulations exhibited high encapsulation efficiency, high physical stability. The drug incorporated SLNs have demonstrated that the controlled release patterns of the drug for prolonged period. The prepared SLNs were characterized for surface morphology by SEM analysis, entrapment efficiency, zeta potential, FTIR, DSC and In-vitro diffusion studies. The hydrodynamic mean diameter and zeta potential were 168.7 ± 1.8 nm and -28.9 ± 2.0 mV for SLN-chitosan-CBZ respectively. Therefore chitosan-SLN can be good candidates to encapsulate CBZ and to increase its therapeutic efficacy in the treatment of Epilepsy.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21205099" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="118de19ce8a0da61d2418d1f66c681ab" rel="nofollow" data-download="{"attachment_id":54183130,"asset_id":21205099,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183130/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21205099 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21205099"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21205099, container: ".js-paper-rank-work_21205099", }); });</script></li><li class="js-percentile-work_21205099 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205099; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21205099"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21205099 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21205099"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205099; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205099]").text(description); $(".js-view-count-work_21205099").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21205099").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21205099"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">11</a>  </div><span class="InlineList-item-text u-textTruncate u-pl10x"><a class="InlineList-item-text" data-has-card-for-ri="9130" rel="nofollow" href="https://www.academia.edu/Documents/in/Chitosan">Chitosan</a>, <script data-card-contents-for-ri="9130" type="text/json">{"id":9130,"name":"Chitosan","url":"https://www.academia.edu/Documents/in/Chitosan","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="23390" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry">Pharmaceutical Chemistry</a>, <script data-card-contents-for-ri="23390" type="text/json">{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="78753" rel="nofollow" href="https://www.academia.edu/Documents/in/Differential_scanning_calorimetry">Differential scanning calorimetry</a>, <script data-card-contents-for-ri="78753" type="text/json">{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="227299" rel="nofollow" href="https://www.academia.edu/Documents/in/Triglycerides">Triglycerides</a><script data-card-contents-for-ri="227299" type="text/json">{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21205099]'), work: {"id":21205099,"title":"Formulation and evaluation of chitosan solid lipid nanoparticles of carbamazepine","created_at":"2016-01-29T22:57:46.551-08:00","owner_id":11079820,"url":"https://www.academia.edu/21205099/Formulation_and_evaluation_of_chitosan_solid_lipid_nanoparticles_of_carbamazepine","slug":"Formulation_and_evaluation_of_chitosan_solid_lipid_nanoparticles_of_carbamazepine","dom_id":"work_21205099","summary":"The present work aims at preparing aqueous suspension of Solid lipid Nanoparticles containing Chitosan (CT) which is a biopolymer that exhibits a number of interesting properties which include controlled drug delivery. Carbamezapine (CBZ) is a lipophilic drug which shows it antiepileptic activity by inactivating sodium channels. The solid lipid Nanoparticles (SLN) of Chitosan-CBZ were prepared by using solvent injection method using ethanol as organic solvent. The prepared SLN formulations exhibited high encapsulation efficiency, high physical stability. The drug incorporated SLNs have demonstrated that the controlled release patterns of the drug for prolonged period. The prepared SLNs were characterized for surface morphology by SEM analysis, entrapment efficiency, zeta potential, FTIR, DSC and In-vitro diffusion studies. The hydrodynamic mean diameter and zeta potential were 168.7 ± 1.8 nm and -28.9 ± 2.0 mV for SLN-chitosan-CBZ respectively. Therefore chitosan-SLN can be good candidates to encapsulate CBZ and to increase its therapeutic efficacy in the treatment of Epilepsy.","publication":"Lipids in Health and Disease","publication_with_fallback":"Lipids in Health and Disease","downloadable_attachments":[{"id":54183130,"asset_id":21205099,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/54183130/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/54183130/Lipids-libre.pdf?1503160264=\u0026response-content-disposition=attachment%3B+filename%3DFormulation_and_evaluation_of_chitosan_s.pdf\u0026Expires=1741108889\u0026Signature=Iv-ySyWNi603e72oDXrrUzT88FUSPU1ZttElBQ5Xpc1P-6ZQZzHida3FAamzJEWpRbG1syyR32wH8CWvxHfAlEKat8D29WIxx2GqSPBCw6dsxh6BBPDDiiLP9TrCQjnD6nD8XW97hPrkQk9ZvZe1qvcMR2ikJuRkU9hp7mGXvMIT1UFCKYLe-Hy-5xXc3QuCDE~1Puwi2ICOT2kK2VwJANF1A1RClwV8U872iQMBWtsEVqRSfsJPqCPDdzEu4zakQymphIdfGyfeKnZNr4X~Y6qEDLJ3kYVYMORKYK3b5at0N21v4rBUffj83qqoB77~7KQjPImJ7flcvbw6eEON2A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/54183130/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/54183130/mini_magick20190118-25788-xj4nxw.png?1547801687"}],"downloadable_attachments_with_full_thumbnails":[{"id":54183130,"asset_id":21205099,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/54183130/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/54183130/Lipids-libre.pdf?1503160264=\u0026response-content-disposition=attachment%3B+filename%3DFormulation_and_evaluation_of_chitosan_s.pdf\u0026Expires=1741108889\u0026Signature=Iv-ySyWNi603e72oDXrrUzT88FUSPU1ZttElBQ5Xpc1P-6ZQZzHida3FAamzJEWpRbG1syyR32wH8CWvxHfAlEKat8D29WIxx2GqSPBCw6dsxh6BBPDDiiLP9TrCQjnD6nD8XW97hPrkQk9ZvZe1qvcMR2ikJuRkU9hp7mGXvMIT1UFCKYLe-Hy-5xXc3QuCDE~1Puwi2ICOT2kK2VwJANF1A1RClwV8U872iQMBWtsEVqRSfsJPqCPDdzEu4zakQymphIdfGyfeKnZNr4X~Y6qEDLJ3kYVYMORKYK3b5at0N21v4rBUffj83qqoB77~7KQjPImJ7flcvbw6eEON2A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/54183130/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/54183130/mini_magick20190118-25788-xj4nxw.png?1547801687"}],"has_pdf":true,"has_fulltext":true,"page_count":8,"ordered_authors":[{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":9130,"name":"Chitosan","url":"https://www.academia.edu/Documents/in/Chitosan","nofollow":true},{"id":23390,"name":"Pharmaceutical Chemistry","url":"https://www.academia.edu/Documents/in/Pharmaceutical_Chemistry","nofollow":true},{"id":78753,"name":"Differential scanning calorimetry","url":"https://www.academia.edu/Documents/in/Differential_scanning_calorimetry","nofollow":true},{"id":227299,"name":"Triglycerides","url":"https://www.academia.edu/Documents/in/Triglycerides","nofollow":true},{"id":300178,"name":"Nanocapsules","url":"https://www.academia.edu/Documents/in/Nanocapsules"},{"id":375054,"name":"Rats","url":"https://www.academia.edu/Documents/in/Rats"},{"id":382466,"name":"Carbamazepine","url":"https://www.academia.edu/Documents/in/Carbamazepine"},{"id":390245,"name":"Particle Size","url":"https://www.academia.edu/Documents/in/Particle_Size"},{"id":398650,"name":"Fourier transform infrared spectroscopy","url":"https://www.academia.edu/Documents/in/Fourier_transform_infrared_spectroscopy"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats"},{"id":651604,"name":"Seizures","url":"https://www.academia.edu/Documents/in/Seizures"}],"publication_year":2012,"publication_year_with_fallback":2012,"paper_rank":null,"all_time_views":17,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21205102 coauthored" data-work_id="21205102" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21205102/In_Vitro_Assessment_and_Pharmacodynamics_of_Nimesulide_Incorporated_Aloe_vera_Transemulgel">In-Vitro Assessment and Pharmacodynamics of Nimesulide Incorporated Aloe vera Transemulgel</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of the investigation was to prepare nimesulide emulsion for incorporation in Aloe vera gel base to formulate &amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;nimesulide - Aloe vera transemulgel&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21205102" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of the investigation was to prepare nimesulide emulsion for incorporation in Aloe vera gel base to formulate &amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;nimesulide - Aloe vera transemulgel&amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; (NAE) and to carryout in-vitro assessment and in-vivo anti-inflammatory studies of the product. Although the use of nimesulide is banned for oral administration, due to its potential for inducing hepatotoxicity and thrombocytopenia, the use of nimesulide for topical delivery is prominent in the treatment of many inflammatory conditions including rheumatoid arthritis. The drug loading capacity of transdermal gels is low for hydrophobic drugs such as nimesulide. Nimesulide can be effectively incorporated into emulgels (a combination of emulsion and gel). Aloe vera has a mild anti-inflammatory effect and in the present study Aloe vera gel was formulated and used as a gel base to prepare NAE. The emulgels thus prepared were evaluated for viscosity, pH, in-vitro permeation, stability and skin irritation test. In-vivo anti-inflammatory studies were performed using carrageenan induced hind paw edema method in Wistar rats. The results were compared with that of commercial nimesulide gel (CNG). From the in-vitro studies, effective permeation of nimesulide from NAE (53.04 %) was observed compared to CNG (44.72 %) at 30 min indicating better drug release from NAE. Topical application of the emulgel found no skin irritation. Stability studies proved the integrity of the formulation. The percentage of inhibition of edema was highest for the prepared NAE (67.4 % inhibition after 240 min) compared to CNG (59.6 %). From our results, it was concluded that the Aloe vera gel acts as an effective gel base to prepare nimesulide emulgel with high drug loading capacity (86.4 % drug content) compared to CNG (70.5 % drug content) with significant anti-inflammatory effect.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21205102" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="11f8fc0506ab8bbf43581fa071744000" rel="nofollow" data-download="{"attachment_id":41829874,"asset_id":21205102,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/41829874/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span><span class="u-displayInlineBlock InlineList-item-text"> and <span class="u-textDecorationUnderline u-clickable InlineList-item-text js-work-more-authors-21205102">+1</span><div class="hidden js-additional-users-21205102"><div><span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a href="https://independent.academia.edu/SundaresanCR">Sundaresan CR</a></span></div></div></span><script>(function(){ var popoverSettings = { el: $('.js-work-more-authors-21205102'), placement: 'bottom', hide_delay: 200, html: true, content: function(){ return $('.js-additional-users-21205102').html(); 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container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21205102 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21205102"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205102; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205102]").text(description); $(".js-view-count-work_21205102").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21205102").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="21205102"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">9</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="109384" rel="nofollow" href="https://www.academia.edu/Documents/in/Viscosity">Viscosity</a>, <script data-card-contents-for-ri="109384" type="text/json">{"id":109384,"name":"Viscosity","url":"https://www.academia.edu/Documents/in/Viscosity","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="119903" rel="nofollow" href="https://www.academia.edu/Documents/in/Aloe">Aloe</a>, <script data-card-contents-for-ri="119903" type="text/json">{"id":119903,"name":"Aloe","url":"https://www.academia.edu/Documents/in/Aloe","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="162553" rel="nofollow" href="https://www.academia.edu/Documents/in/Skin">Skin</a>, <script data-card-contents-for-ri="162553" type="text/json">{"id":162553,"name":"Skin","url":"https://www.academia.edu/Documents/in/Skin","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="284907" rel="nofollow" href="https://www.academia.edu/Documents/in/Gels">Gels</a><script data-card-contents-for-ri="284907" type="text/json">{"id":284907,"name":"Gels","url":"https://www.academia.edu/Documents/in/Gels","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=21205102]'), work: {"id":21205102,"title":"In-Vitro Assessment and Pharmacodynamics of Nimesulide Incorporated Aloe vera Transemulgel","created_at":"2016-01-29T22:57:46.938-08:00","owner_id":11079820,"url":"https://www.academia.edu/21205102/In_Vitro_Assessment_and_Pharmacodynamics_of_Nimesulide_Incorporated_Aloe_vera_Transemulgel","slug":"In_Vitro_Assessment_and_Pharmacodynamics_of_Nimesulide_Incorporated_Aloe_vera_Transemulgel","dom_id":"work_21205102","summary":"The aim of the investigation was to prepare nimesulide emulsion for incorporation in Aloe vera gel base to formulate \u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;#39;nimesulide - Aloe vera transemulgel\u0026amp;amp;amp;amp;amp;amp;amp;amp;amp;#39; (NAE) and to carryout in-vitro assessment and in-vivo anti-inflammatory studies of the product. Although the use of nimesulide is banned for oral administration, due to its potential for inducing hepatotoxicity and thrombocytopenia, the use of nimesulide for topical delivery is prominent in the treatment of many inflammatory conditions including rheumatoid arthritis. The drug loading capacity of transdermal gels is low for hydrophobic drugs such as nimesulide. Nimesulide can be effectively incorporated into emulgels (a combination of emulsion and gel). Aloe vera has a mild anti-inflammatory effect and in the present study Aloe vera gel was formulated and used as a gel base to prepare NAE. The emulgels thus prepared were evaluated for viscosity, pH, in-vitro permeation, stability and skin irritation test. In-vivo anti-inflammatory studies were performed using carrageenan induced hind paw edema method in Wistar rats. The results were compared with that of commercial nimesulide gel (CNG). From the in-vitro studies, effective permeation of nimesulide from NAE (53.04 %) was observed compared to CNG (44.72 %) at 30 min indicating better drug release from NAE. Topical application of the emulgel found no skin irritation. Stability studies proved the integrity of the formulation. The percentage of inhibition of edema was highest for the prepared NAE (67.4 % inhibition after 240 min) compared to CNG (59.6 %). From our results, it was concluded that the Aloe vera gel acts as an effective gel base to prepare nimesulide emulgel with high drug loading capacity (86.4 % drug content) compared to CNG (70.5 % drug content) with significant anti-inflammatory effect.","publication":"Current Drug Discovery Technologies","publication_with_fallback":"Current Drug Discovery Technologies","downloadable_attachments":[{"id":41829874,"asset_id":21205102,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://a.academia-assets.com/images/blank-paper.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/41829874/Nimesulide_CDDT.pdf?1738286572=\u0026response-content-disposition=attachment%3B+filename%3DIn_Vitro_Assessment_and_Pharmacodynamics.pdf\u0026Expires=1741108889\u0026Signature=SFDqANobX1t2dZPQXRAjBUHiue10LnEZtyq8twC2Iq8jo2Rv8qlPrGJNjkVf69byiJBJKnIE1jgXmYFCpDom-HIglhU6w6f2BIrrVNMJ-LAAH0gOay156eH4pj7UTfjMeVxEXLzUhrSOnT-EKhRtUxEmBFRQRBhdsKJvIk~DQlz2Jtnp1JJL8H2FxFF66HZtCS54cASsaWwgsVGXW-9tsuawfhF-bHAKOdQm8wY3g4VvlYqtTk6CcOoaxAAbDNGkaEFSDN88qsD-aj0mOs4585qNi4hNxt~ulFNgQHVnWdeKZ3E5QR7pvOAJPN7gKQ8h7IYVb31T6nefuQ9YQrYm8A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/41829874/download_file?st=MTc0MTEwNTI4OSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":null}],"downloadable_attachments_with_full_thumbnails":[],"has_pdf":true,"has_fulltext":true,"page_count":null,"ordered_authors":[{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"},{"id":27819357,"first_name":"Sundaresan","last_name":"CR","domain_name":"independent","page_name":"SundaresanCR","display_name":"Sundaresan CR","profile_url":"https://independent.academia.edu/SundaresanCR","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":109384,"name":"Viscosity","url":"https://www.academia.edu/Documents/in/Viscosity","nofollow":true},{"id":119903,"name":"Aloe","url":"https://www.academia.edu/Documents/in/Aloe","nofollow":true},{"id":162553,"name":"Skin","url":"https://www.academia.edu/Documents/in/Skin","nofollow":true},{"id":284907,"name":"Gels","url":"https://www.academia.edu/Documents/in/Gels","nofollow":true},{"id":382481,"name":"Edema","url":"https://www.academia.edu/Documents/in/Edema"},{"id":564879,"name":"Wistar Rats","url":"https://www.academia.edu/Documents/in/Wistar_Rats"},{"id":568887,"name":"Carrageenan","url":"https://www.academia.edu/Documents/in/Carrageenan"},{"id":1135814,"name":"Drug Stability","url":"https://www.academia.edu/Documents/in/Drug_Stability"},{"id":1137254,"name":"Hydrogen-Ion Concentration","url":"https://www.academia.edu/Documents/in/Hydrogen-Ion_Concentration"}],"publication_year":2014,"publication_year_with_fallback":2014,"paper_rank":null,"all_time_views":71,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_21205103" data-work_id="21205103" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/21205103/Pharmacological_profiling_of_Argemone_mexicana_for_its_aphrodisiac_potentials_in_male_Wistar_rats">Pharmacological profiling of Argemone mexicana for its aphrodisiac potentials in male Wistar rats</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">ABSTRACT Objective: To study the aphrodisiac potentials of ethanol extract of Argemone mexicana L. (A. mexicana) of Papaveraceae family in sexually sluggish male Wistar rats. Methods: The sexually tirneaactteidv ew mitha leet hraatnso lw... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_21205103" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">ABSTRACT Objective: To study the aphrodisiac potentials of ethanol extract of Argemone mexicana L. (A. mexicana) of Papaveraceae family in sexually sluggish male Wistar rats. Methods: The sexually tirneaactteidv ew mitha leet hraatnso lw eexretr adcitv iodf eAd. imnteox itcwaon ag r(EouEpAsM o) fa 8t 1r agt/sk ega dcahi.l yT horea lt edsot sger ofourp 2 a8n dimayasl.s Owthereer gmroouunpt ,a innitmroamlsi swsieorne, terjeaactuelda twiointh; psoilsdt eenjaafciul lcaittorrayt ep aaut saen a onrda lf rdeoqsuee nocf i5e sm ogf /mkgo.u Tnht,e i nlatrtoemncisiessio nof, wanedre e ejasctiumlaattieodn uwseinreg mELeIaSsAu.r eRde osnu l0ts, :7 Tthh,e 1 E4tEhA, M21 wsta as nndo n2l8etthh adla yesv.e nS eartu mdo stees toof s4te.0r ogn/ek gl.e vTehles borya l idnocsrienags eo fi nE EanAoM- g ehnaist asli g ninifviceastnitglayt oernyh a bnecheadv iothr,e f roerqieunetnactiieosn o fo fm omuanlte,s in ttorwomaridsss io fne,m aanlde ejaculation (P&amp;lt; 0.01). The latencies of mount, intromission and ejaculation were significantly decreased (P&amp;lt;0.05). The EEAM has produced marked variation in sexual behavior characteristics and was able to elevate the serum testosterone levels (P&amp;lt;0.01) on par to that of sildenafil citrate. Conclusion: The EEAM has elevated sexual dysfunctions in male rats. These potentials may bvaes rceullaatteudr et</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/21205103" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="de18831b045e296f67bc292f9861aeaa" rel="nofollow" data-download="{"attachment_id":54183105,"asset_id":21205103,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183105/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_21205103 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="21205103"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 21205103, container: ".js-paper-rank-work_21205103", }); });</script></li><li class="js-percentile-work_21205103 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 21205103; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_21205103"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_21205103 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="21205103"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 21205103; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=21205103]").text(description); $(".js-view-count-work_21205103").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_21205103").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34276343" data-work_id="34276343" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34276343/Pharmaceutical_Investigation">Pharmaceutical Investigation</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Background: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic evaluation of the formulation. Materials and Methods: The gel was prepared by using carbopol 934 as gelling agent and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34276343" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Background: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic<br />evaluation of the formulation. Materials and Methods: The gel was prepared by using carbopol 934 as gelling agent and<br />methyl paraben as a preservative in an Aloe vera gel base. The formulated gel was also evaluated for physicochemical<br />parameters like pH, viscosity, drug content, and in vitro diffusion assessment. Pharmacodynamic activity of the formulation<br />was evaluated in Wistar albino rats. The formulated gel was compared with that of similar marketed gel (commercial<br />piroxicam gel (CPG)) against the same parameters. Results: From in vitro studies, an effective drug release from PAG<br />was observed to be 68.17% when compared with that of the CPG (62.71%) at 180 min indicating better drug release<br />from the gel formulated in this study. Percentage inhibition of edema was greater for the preparation of PAG (29.57<br />mean percent inhibition after 60 min) compared to marketed gel which exhibited 18.3% after 60 min. Conclusion: It was<br />concluded from the results that the Aloe vera gel acts as an effective gel base to prepare piroxicam gel with high drug<br />loading capacity and improved anti-inflammatory effect. From the statistical analysis the formulation of PAG showed<br />better release than the CPG at p < 0.05 level of significance.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34276343" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="422987e359d62fb92a68fc121c8c6a6a" rel="nofollow" data-download="{"attachment_id":54183188,"asset_id":34276343,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183188/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34276343 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34276343"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34276343, container: ".js-paper-rank-work_34276343", }); 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$(".js-view-count[data-work-id=34276343]").text(description); $(".js-view-count-work_34276343").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34276343").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34276343"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">2</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="140" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacology">Pharmacology</a>, <script data-card-contents-for-ri="140" type="text/json">{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="656" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a><script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34276343]'), work: {"id":34276343,"title":"Pharmaceutical Investigation","created_at":"2017-08-19T09:34:10.838-07:00","owner_id":11079820,"url":"https://www.academia.edu/34276343/Pharmaceutical_Investigation","slug":"Pharmaceutical_Investigation","dom_id":"work_34276343","summary":"Background: The aim of the study was to develop piroxicam-Aloe vera gel (PAG) formulation and make a pharmacodynamic\nevaluation of the formulation. Materials and Methods: The gel was prepared by using carbopol 934 as gelling agent and\nmethyl paraben as a preservative in an Aloe vera gel base. The formulated gel was also evaluated for physicochemical\nparameters like pH, viscosity, drug content, and in vitro diffusion assessment. Pharmacodynamic activity of the formulation\nwas evaluated in Wistar albino rats. The formulated gel was compared with that of similar marketed gel (commercial\npiroxicam gel (CPG)) against the same parameters. Results: From in vitro studies, an effective drug release from PAG\nwas observed to be 68.17% when compared with that of the CPG (62.71%) at 180 min indicating better drug release\nfrom the gel formulated in this study. Percentage inhibition of edema was greater for the preparation of PAG (29.57\nmean percent inhibition after 60 min) compared to marketed gel which exhibited 18.3% after 60 min. Conclusion: It was\nconcluded from the results that the Aloe vera gel acts as an effective gel base to prepare piroxicam gel with high drug\nloading capacity and improved anti-inflammatory effect. From the statistical analysis the formulation of PAG showed\nbetter release than the CPG at p \u003c 0.05 level of significance.","publication":null,"publication_with_fallback":null,"downloadable_attachments":[{"id":54183188,"asset_id":34276343,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/54183188/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/54183188/PharmInvestigations_2013_3_4_212_121303_1-libre.pdf?1503160761=\u0026response-content-disposition=attachment%3B+filename%3DPharmaceutical_Investigation.pdf\u0026Expires=1741108890\u0026Signature=bvsXG4xsN57iS60iVfSFeK5QoBzRPXaq9PVJSJV63fmh4rmVkwxOFLNqBQi8-nDjoV3i~1rcC9fnpXHUolxqBrG6Jx4US6QPSgHqAs55Frvuqeyj5XQZEjO5KDdW4rRrXwcMOvunTsJ3dBp~-nc5hf-QIEPA12Lq-qaM2ZOmLN9YC5z~v3IP0Mip~tuhpkucc-u0RKFDhOJhlW8MxU5rxDRlOFbPTBA0rub2zuE7sHOmAv-nd9OAT6v7FJdVpgo8Ty~OOg-OxL0RjS~Z013RmCJ1rCBZiABgIJsr~ILSQNOjDDNAtGG0ajoVZo0yw~oo7BCLCfniYTXEp-Xhw04ysQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/54183188/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":null}],"downloadable_attachments_with_full_thumbnails":[],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":140,"name":"Pharmacology","url":"https://www.academia.edu/Documents/in/Pharmacology","nofollow":true},{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}],"publication_year":null,"publication_year_with_fallback":null,"paper_rank":null,"all_time_views":95,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_34276366" data-work_id="34276366" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/34276366/Potential_of_microemulsified_entacapone_drug_delivery_systems_in_the_management_of_acute_Parkinsons_disease">Potential of microemulsified entacapone drug delivery systems in the management of acute Parkinson's disease</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Objective: To design solid self-microemulsifying drug delivery system (S-SMEDDS) of entacapone and evaluate for its anti-Parkinson's potentials. Methods: Solubility studies were performed in various vehicles i.e., oils, surfactants and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_34276366" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Objective: To design solid self-microemulsifying drug delivery system (S-SMEDDS) of entacapone and evaluate for its anti-Parkinson's potentials.<br />Methods: Solubility studies were performed in various vehicles i.e., oils, surfactants and co-surfactants and pseudo-ternary phase diagrams were plotted to understand the microemulsion formation region. Liquid self-microemulsifying drug delivery systems (SMEDDS) were developed using gingelly and rice bran oil as lipid vehicles, Tween 80 and Span 20 as surfactants and glycerin, propylene glycol as co-surfactants. They were characterized by Fourier transform infrared spectroscopy, pH, viscosity, zeta potential, polydispersibility index and droplet size analysis and evaluated for drug content, in-vitro release, in-vitro diffusion and ex-vivo permeation. Optimized liquid SMEDDS were converted into S-SMEDDS by adsorption and melt granulation procedures. Characterization by differential scanning calorimetry, SEM, micrometrics, reconstitution property, moisture content and evaluation by drug content, drug release kinetics and shelf-life were performed for S-SMEDDS. Parkinsonism was induced and pharmacodynamic potentials of S-SMEDDS were evaluated.<br />Results: S-SMEDDS formulation AG8 had shown the highest drug release of 90.92% within 60 min. Pharmacodynamic studies also proved the efficiency of entacapone SSMEDDS against Parkinsonism.<br />Conclusions: Entacapone S-SMEDDS is an effective drug delivery system that offers more predictable and extensive drug release with enhanced shelf-life in the treatment of acute Parkinsonism.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/34276366" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6f9b7529c3e8e3792ec53b4159102d14" rel="nofollow" data-download="{"attachment_id":54183214,"asset_id":34276366,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/54183214/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="11079820" href="https://jntua.academia.edu/PrasannaRajuY">Prasanna Raju Y</a><script data-card-contents-for-user="11079820" type="text/json">{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}</script></span></span></li><li class="js-paper-rank-work_34276366 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="34276366"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 34276366, container: ".js-paper-rank-work_34276366", }); 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$(".js-view-count[data-work-id=34276366]").text(description); $(".js-view-count-work_34276366").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_34276366").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="34276366"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="70046" rel="nofollow" href="https://www.academia.edu/Documents/in/Microemulsion">Microemulsion</a><script data-card-contents-for-ri="70046" type="text/json">{"id":70046,"name":"Microemulsion","url":"https://www.academia.edu/Documents/in/Microemulsion","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=34276366]'), work: {"id":34276366,"title":"Potential of microemulsified entacapone drug delivery systems in the management of acute Parkinson's disease","created_at":"2017-08-19T09:37:15.443-07:00","owner_id":11079820,"url":"https://www.academia.edu/34276366/Potential_of_microemulsified_entacapone_drug_delivery_systems_in_the_management_of_acute_Parkinsons_disease","slug":"Potential_of_microemulsified_entacapone_drug_delivery_systems_in_the_management_of_acute_Parkinsons_disease","dom_id":"work_34276366","summary":"Objective: To design solid self-microemulsifying drug delivery system (S-SMEDDS) of entacapone and evaluate for its anti-Parkinson's potentials.\nMethods: Solubility studies were performed in various vehicles i.e., oils, surfactants and co-surfactants and pseudo-ternary phase diagrams were plotted to understand the microemulsion formation region. Liquid self-microemulsifying drug delivery systems (SMEDDS) were developed using gingelly and rice bran oil as lipid vehicles, Tween 80 and Span 20 as surfactants and glycerin, propylene glycol as co-surfactants. They were characterized by Fourier transform infrared spectroscopy, pH, viscosity, zeta potential, polydispersibility index and droplet size analysis and evaluated for drug content, in-vitro release, in-vitro diffusion and ex-vivo permeation. Optimized liquid SMEDDS were converted into S-SMEDDS by adsorption and melt granulation procedures. Characterization by differential scanning calorimetry, SEM, micrometrics, reconstitution property, moisture content and evaluation by drug content, drug release kinetics and shelf-life were performed for S-SMEDDS. Parkinsonism was induced and pharmacodynamic potentials of S-SMEDDS were evaluated.\nResults: S-SMEDDS formulation AG8 had shown the highest drug release of 90.92% within 60 min. Pharmacodynamic studies also proved the efficiency of entacapone SSMEDDS against Parkinsonism.\nConclusions: Entacapone S-SMEDDS is an effective drug delivery system that offers more predictable and extensive drug release with enhanced shelf-life in the treatment of acute Parkinsonism.","publication":null,"publication_with_fallback":null,"downloadable_attachments":[{"id":54183214,"asset_id":34276366,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/54183214/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/54183214/Entacapone-JOAD-2016-libre.pdf?1503160884=\u0026response-content-disposition=attachment%3B+filename%3DPotential_of_microemulsified_entacapone.pdf\u0026Expires=1741108890\u0026Signature=cmlgdQxJd24s9ICTCW6JGgx0780a4iL6xnNEo9CehI8u1ftSOULxcSGCFl1PXHT-dXOxSQ43ZLGML1WPvL2BtxaZ7zua8ilSRDzfwEYuk9fNHQKiI2R8Mdd0zBLyXtQUVP5PPndtY81AqWG8eN2LAOhP50JELho6qsuSfsZrUBZxfVCoDUbre0DYNGkRrTM0ADlJA85wbM25B4ciXdt4sNeJf8BdcbYvzePkXakmdmkNJ2OVtR3sB4Jzd3tig2oF0GYmyQF-0oK5LNXYRWWPcYdDyt-SEuy-BQBrLeOHSqt87sGyWhAzQ4G6D~O31xfQpGNo-PRPI3yvIEayCh1yOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/54183214/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/54183214/mini_magick20190118-14710-1v9j671.png?1547801632"}],"downloadable_attachments_with_full_thumbnails":[{"id":54183214,"asset_id":34276366,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/54183214/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/54183214/Entacapone-JOAD-2016-libre.pdf?1503160884=\u0026response-content-disposition=attachment%3B+filename%3DPotential_of_microemulsified_entacapone.pdf\u0026Expires=1741108890\u0026Signature=cmlgdQxJd24s9ICTCW6JGgx0780a4iL6xnNEo9CehI8u1ftSOULxcSGCFl1PXHT-dXOxSQ43ZLGML1WPvL2BtxaZ7zua8ilSRDzfwEYuk9fNHQKiI2R8Mdd0zBLyXtQUVP5PPndtY81AqWG8eN2LAOhP50JELho6qsuSfsZrUBZxfVCoDUbre0DYNGkRrTM0ADlJA85wbM25B4ciXdt4sNeJf8BdcbYvzePkXakmdmkNJ2OVtR3sB4Jzd3tig2oF0GYmyQF-0oK5LNXYRWWPcYdDyt-SEuy-BQBrLeOHSqt87sGyWhAzQ4G6D~O31xfQpGNo-PRPI3yvIEayCh1yOw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/54183214/download_file?st=MTc0MTEwNTI5MCw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/54183214/mini_magick20190118-14710-1v9j671.png?1547801632"}],"has_pdf":true,"has_fulltext":true,"page_count":12,"ordered_authors":[{"id":11079820,"first_name":"Prasanna Raju","last_name":"Y","domain_name":"jntua","page_name":"PrasannaRajuY","display_name":"Prasanna Raju Y","profile_url":"https://jntua.academia.edu/PrasannaRajuY","photo":"/images/s65_no_pic.png"}],"research_interests":[{"id":70046,"name":"Microemulsion","url":"https://www.academia.edu/Documents/in/Microemulsion","nofollow":true}],"publication_year":null,"publication_year_with_fallback":null,"paper_rank":null,"all_time_views":23,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_115421084" data-work_id="115421084" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/115421084/Implantable_drug_delivery_systems_An_overview">Implantable drug delivery systems: An overview</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest">Rajgor, et al.: Recent advances in implantable drug delivery system Figure 6: Schematic of an implantable rod</div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/115421084" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="02f44677d19ce17790d4e09960c6043d" rel="nofollow" data-download="{"attachment_id":111831989,"asset_id":115421084,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button 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js-work-link" href="https://www.academia.edu/92968001/Challenges_in_the_Research_and_Development_of_Orphan_Drugs_A_Review">Challenges in the Research and Development of Orphan Drugs: A Review</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Pharmaceutical agents which treat rare medical conditions like orphan or rare diseases are called “orphan drugs”. The name ‘orphan’ itself indicates that the pharmaceutical industries are showing less interest in the development and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_92968001" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pharmaceutical agents which treat rare medical conditions like orphan or rare diseases are called “orphan drugs”. The name ‘orphan’ itself indicates that the pharmaceutical industries are showing less interest in the development and marketing of drugs intended only for a small number of patients. Difficulty in the diagnosis and therapeutic management of rare disease is the major challenge in the development of orphan drug. In recent years, progress has been made in the development of orphan drugs by pharma industries due to enactment of different regulations, administration authorities, tax benefits, marketing rights and public awareness by different countries. 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The name 'orphan' itself indicates that the pharmaceutical industries are showing less interest in the development and... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_108723915" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Pharmaceutical agents which treat rare medical conditions like orphan or rare diseases are called "orphan drugs". The name 'orphan' itself indicates that the pharmaceutical industries are showing less interest in the development and marketing of drugs intended only for a small number of patients. Difficulty in the diagnosis and therapeutic management of rare disease is the major challenge in the development of orphan drug. In recent years, progress has been made in the development of orphan drugs by pharma industries due to enactment of different regulations, administration authorities, tax benefits, marketing rights and public awareness by different countries. This review provides an overview of incentives, marketing rights and administrative authorities of different countries like U.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/108723915" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="f9eaa4db94085b4e166ee0f569cd7e5e" rel="nofollow" data-download="{"attachment_id":107033799,"asset_id":108723915,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/107033799/download_file?st=MTc0MTEwNTI5MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_108723915 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="108723915"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 108723915, container: ".js-paper-rank-work_108723915", }); 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$(".js-view-count[data-work-id=108723915]").text(description); $(".js-view-count-work_108723915").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_108723915").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="108723915"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i>  <a class="InlineList-item-text u-positionRelative">5</a>  </div><span class="InlineList-item-text u-textTruncate u-pl9x"><a class="InlineList-item-text" data-has-card-for-ri="26" rel="nofollow" href="https://www.academia.edu/Documents/in/Business">Business</a>, <script data-card-contents-for-ri="26" type="text/json">{"id":26,"name":"Business","url":"https://www.academia.edu/Documents/in/Business","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="10347" rel="nofollow" href="https://www.academia.edu/Documents/in/European_Union">European Union</a>, <script data-card-contents-for-ri="10347" type="text/json">{"id":10347,"name":"European Union","url":"https://www.academia.edu/Documents/in/European_Union","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="95655" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmaceutical">Pharmaceutical</a>, <script data-card-contents-for-ri="95655" type="text/json">{"id":95655,"name":"Pharmaceutical","url":"https://www.academia.edu/Documents/in/Pharmaceutical","nofollow":true}</script><a class="InlineList-item-text" data-has-card-for-ri="185860" rel="nofollow" href="https://www.academia.edu/Documents/in/Incentive">Incentive</a><script data-card-contents-for-ri="185860" type="text/json">{"id":185860,"name":"Incentive","url":"https://www.academia.edu/Documents/in/Incentive","nofollow":true}</script></span></li><script>(function(){ if (true) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=108723915]'), work: {"id":108723915,"title":"Challenges in the Research and Development of Orphan Drugs: A Review","created_at":"2023-10-30T04:10:49.100-07:00","owner_id":229895351,"url":"https://www.academia.edu/108723915/Challenges_in_the_Research_and_Development_of_Orphan_Drugs_A_Review","slug":"Challenges_in_the_Research_and_Development_of_Orphan_Drugs_A_Review","dom_id":"work_108723915","summary":"Pharmaceutical agents which treat rare medical conditions like orphan or rare diseases are called \"orphan drugs\". The name 'orphan' itself indicates that the pharmaceutical industries are showing less interest in the development and marketing of drugs intended only for a small number of patients. Difficulty in the diagnosis and therapeutic management of rare disease is the major challenge in the development of orphan drug. In recent years, progress has been made in the development of orphan drugs by pharma industries due to enactment of different regulations, administration authorities, tax benefits, marketing rights and public awareness by different countries. 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Fluoxetine and Sertraline solid dispersions were prepared using PEG... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_124568708" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The main aim of the study was to enhance dissolution rate of Fluoxetine and Sertraline hydrochloride by formulating as solid dispersions using solvent evaporation method. Fluoxetine and Sertraline solid dispersions were prepared using PEG 4000 as polymer. PEGylated conjugates were prepared in the weight ratios of 1:0.5, 1:1, 1:2, 1:3, and 1:4 using solvent evaporation method. Physicochemical properties were evaluated using solubility studies, FTIR, powder XRD, SEM, dissolution studies. From solubility studies F5, S5 showed highest solubility. From FTIR studies it was proved that there was no interaction between drug and polymer. From SEM and powder XRD studies it was observed that change of polymorphic form of Fluoxetine and Sertraline from crystalline to amorphous form within the solid dispersion. From dissolution studies data it was observed that F5 and S5 showed maximum drug release within 45, 60min respectively, hence they were considered as optimized formulations. Based on the results, it can be concluded that developed solid dispersions was successful to enhance dissolution rate of both the drugs.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/124568708" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="6d6f6e4e974c7ce7fdd3050606a47d9f" rel="nofollow" data-download="{"attachment_id":118769485,"asset_id":124568708,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/118769485/download_file?st=MTc0MTEwNTI5MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_124568708 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="124568708"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 124568708, container: ".js-paper-rank-work_124568708", }); });</script></li><li class="js-percentile-work_124568708 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124568708; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_124568708"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_124568708 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="124568708"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124568708; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124568708]").text(description); $(".js-view-count-work_124568708").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_124568708").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_124568788" data-work_id="124568788" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/124568788/oral_fast_dissolving_films">oral fast dissolving films</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The concept of fast dissolving oral films has become popular as an alternative to fast dissolving tablets. Oral films by reducing the frequency of dosage can provide maximum therapeutic efficacy, enhanced bioavailability and stability.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_124568788" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The concept of fast dissolving oral films has become popular as an alternative to fast dissolving tablets. Oral films by reducing the frequency of dosage can provide maximum therapeutic efficacy, enhanced bioavailability and stability. They will also skip the first pass metabolism of drugs. These advantages made this formulation most approved among geriatric and pediatric patients and patients with fear of choking. The present study aimed to develop and evaluate fast dissolving oral films of Fluoxetine HCl by using different film forming polymers like pullulan and PVA by solvent casting method. Six formulations of Fluoxetine HCl were prepared using different ratio's of polymers. The films were evaluated for thickness, weight uniformity, folding endurance, in-vitro disintegration, in-vitro dissolution, FTIR studies, SEM, XRD studies, in-vitro wetting studies, % moisture uptake and drug content. Among all the formulations optimized formulation showed disintegration time within 1min with highest dissolution rate of 97.8% within 12min. Based on the results, it can be concluded that the developed formulation was successful to enhance drug delivery and onset of action.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/124568788" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="c92973681beda801c476b0f5011cf42e" rel="nofollow" data-download="{"attachment_id":118769551,"asset_id":124568788,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/118769551/download_file?st=MTc0MTEwNTI5MSw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_124568788 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="124568788"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 124568788, container: ".js-paper-rank-work_124568788", }); });</script></li><li class="js-percentile-work_124568788 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124568788; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_124568788"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_124568788 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="124568788"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124568788; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124568788]").text(description); $(".js-view-count-work_124568788").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_124568788").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="124568788"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="656" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a><script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=124568788]'), work: {"id":124568788,"title":"oral fast dissolving films","created_at":"2024-10-09T04:18:19.358-07:00","owner_id":229895351,"url":"https://www.academia.edu/124568788/oral_fast_dissolving_films","slug":"oral_fast_dissolving_films","dom_id":"work_124568788","summary":"The concept of fast dissolving oral films has become popular as an alternative to fast dissolving tablets. Oral films by reducing the frequency of dosage can provide maximum therapeutic efficacy, enhanced bioavailability and stability. They will also skip the first pass metabolism of drugs. These advantages made this formulation most approved among geriatric and pediatric patients and patients with fear of choking. The present study aimed to develop and evaluate fast dissolving oral films of Fluoxetine HCl by using different film forming polymers like pullulan and PVA by solvent casting method. Six formulations of Fluoxetine HCl were prepared using different ratio's of polymers. The films were evaluated for thickness, weight uniformity, folding endurance, in-vitro disintegration, in-vitro dissolution, FTIR studies, SEM, XRD studies, in-vitro wetting studies, % moisture uptake and drug content. Among all the formulations optimized formulation showed disintegration time within 1min with highest dissolution rate of 97.8% within 12min. Based on the results, it can be concluded that the developed formulation was successful to enhance drug delivery and onset of action.","publication":"IJPSRR","publication_with_fallback":"IJPSRR","downloadable_attachments":[{"id":118769551,"asset_id":124568788,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/118769551/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/118769551/phd_2-libre.pdf?1728475302=\u0026response-content-disposition=attachment%3B+filename%3Doral_fast_dissolving_films.pdf\u0026Expires=1741108891\u0026Signature=ZK4Qh9xlTIPX~eVLP6XUV8mIsgfKcZFV~3pUOceVWBj9KGjgObGdzt2zybW-nn1ZxH-KGByUflOTj4FDtimN687BJLDXi2fZYbbkf17mo~jDnRld1mmooW3oZQEINtz21bseOFl09XtCf5jhwBcflO2ldcvOoAGlUudi162l49wAeNRSKP2~E0pQkUvcXS-cZaPTsbOuw40u8JQzLd~Skx7MduiYL8nuqbz40KkbqC5rJMzPFAGlovbL7WADWx38pYRYmITwsvnlrA4hfp1US~hgpjgLBDCrbyGd9ZyrWOeklI6o2IrbgRwRXunxOl1yL8lov6JtICoUOTce2TrMiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/118769551/download_file?st=MTc0MTEwNTI5MSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/118769551/mini_magick20241009-1-c6cine.png?1728472696"}],"downloadable_attachments_with_full_thumbnails":[{"id":118769551,"asset_id":124568788,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/118769551/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/118769551/phd_2-libre.pdf?1728475302=\u0026response-content-disposition=attachment%3B+filename%3Doral_fast_dissolving_films.pdf\u0026Expires=1741108891\u0026Signature=ZK4Qh9xlTIPX~eVLP6XUV8mIsgfKcZFV~3pUOceVWBj9KGjgObGdzt2zybW-nn1ZxH-KGByUflOTj4FDtimN687BJLDXi2fZYbbkf17mo~jDnRld1mmooW3oZQEINtz21bseOFl09XtCf5jhwBcflO2ldcvOoAGlUudi162l49wAeNRSKP2~E0pQkUvcXS-cZaPTsbOuw40u8JQzLd~Skx7MduiYL8nuqbz40KkbqC5rJMzPFAGlovbL7WADWx38pYRYmITwsvnlrA4hfp1US~hgpjgLBDCrbyGd9ZyrWOeklI6o2IrbgRwRXunxOl1yL8lov6JtICoUOTce2TrMiA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/118769551/download_file?st=MTc0MTEwNTI5MSw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/118769551/mini_magick20241009-1-c6cine.png?1728472696"}],"has_pdf":true,"has_fulltext":true,"page_count":6,"ordered_authors":[{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}],"research_interests":[{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}],"publication_year":2022,"publication_year_with_fallback":2022,"paper_rank":null,"all_time_views":2,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_124568823" data-work_id="124568823" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/124568823/POSTPARTUM_MOOD_DISORDERS_A_THREAT_TO_NEW_MOTHERS_AND_INFANTS">POSTPARTUM MOOD DISORDERS: A THREAT TO NEW MOTHERS AND INFANTS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Introduction: Postpartum mood disorders like postpartum depression (PPD) may affect women after child birth. History: It is often observed in patients who have past history of major depression post pregnancy and during pregnancy. It is... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_124568823" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Introduction: Postpartum mood disorders like postpartum depression (PPD) may affect women after child birth. History: It is often observed in patients who have past history of major depression post pregnancy and during pregnancy. It is difficult to recognise mothers suffering with postpartum depression that leads to delay in their treatment. Postpartum mood disorders have a negative impact on mother and child bonding which affects child growth and development. Treatment: Treatment protocol of the patient is based on the symptom severity. Mild cases of postpartum mood disorders, can be treated with psychotherapy. In moderate to severe cases, treatment protocol starts with psychotherapy and progress to pharmacotherapy. Pharmacological treatment for PPD is similar to major depression in terms of antidepressant dose. In severe cases of PPD, electro convulsive therapy (ECT) showed better results. Conclusion: The percentage of women suffering with PPD has increased drastically due to the situations like COVID restrictions, nuclear families, lack of help from family members, life style modifications, marital dissatisfaction, lack of support from partner, lack of idea in handling a baby.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/124568823" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="91d114961069d08fbd6b06f5192e1884" rel="nofollow" data-download="{"attachment_id":118769592,"asset_id":124568823,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/118769592/download_file?st=MTc0MTEwNTI5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_124568823 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="124568823"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 124568823, container: ".js-paper-rank-work_124568823", }); });</script></li><li class="js-percentile-work_124568823 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124568823; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_124568823"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_124568823 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="124568823"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124568823; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124568823]").text(description); $(".js-view-count-work_124568823").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_124568823").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="124568823"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="656" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a><script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=124568823]'), work: {"id":124568823,"title":"POSTPARTUM MOOD DISORDERS: A THREAT TO NEW MOTHERS AND INFANTS","created_at":"2024-10-09T04:20:36.165-07:00","owner_id":229895351,"url":"https://www.academia.edu/124568823/POSTPARTUM_MOOD_DISORDERS_A_THREAT_TO_NEW_MOTHERS_AND_INFANTS","slug":"POSTPARTUM_MOOD_DISORDERS_A_THREAT_TO_NEW_MOTHERS_AND_INFANTS","dom_id":"work_124568823","summary":"Introduction: Postpartum mood disorders like postpartum depression (PPD) may affect women after child birth. History: It is often observed in patients who have past history of major depression post pregnancy and during pregnancy. It is difficult to recognise mothers suffering with postpartum depression that leads to delay in their treatment. Postpartum mood disorders have a negative impact on mother and child bonding which affects child growth and development. Treatment: Treatment protocol of the patient is based on the symptom severity. Mild cases of postpartum mood disorders, can be treated with psychotherapy. In moderate to severe cases, treatment protocol starts with psychotherapy and progress to pharmacotherapy. Pharmacological treatment for PPD is similar to major depression in terms of antidepressant dose. In severe cases of PPD, electro convulsive therapy (ECT) showed better results. Conclusion: The percentage of women suffering with PPD has increased drastically due to the situations like COVID restrictions, nuclear families, lack of help from family members, life style modifications, marital dissatisfaction, lack of support from partner, lack of idea in handling a baby.","publication":"World journal of pharmaceutical research","publication_with_fallback":"World journal of pharmaceutical research","downloadable_attachments":[{"id":118769592,"asset_id":124568823,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/118769592/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/118769592/ppd_article-libre.pdf?1728475291=\u0026response-content-disposition=attachment%3B+filename%3DPOSTPARTUM_MOOD_DISORDERS_A_THREAT_TO_NE.pdf\u0026Expires=1741108891\u0026Signature=gZV7EjfHUTgLS~j7YVj2rrN2GvYQQTmDD1Srzl3vWNKtUhU1DkKGKgGcucqLw1Ajb87bipRaT0eC4l~RQgD-k7FAIEsBQ0AtEkgNm6OeL8WU9Rhi9ajFGMevAxZ0VqsVbRlegCT1k4CLARiYOjxUY1LqoMRXrUkkqy81HmlGLW4bIWT1d17dIqfUoYbRJtoK1nOdoyDoPl8y4nWsT6b9h1eOhdJSJT0YluKCaJKGA2kwXghZtlVdMkoCS5zUHndX8hHzcXGAYWRdUJDrLKwgnABwNdugvw8KKqQYnNS-LaRRmk3~L5cCGYGDqC--zufRpf-mtWB3rOWTcS8V7JXa~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/118769592/download_file?st=MTc0MTEwNTI5Miw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/118769592/mini_magick20241009-1-v8yy9f.png?1728472834"}],"downloadable_attachments_with_full_thumbnails":[{"id":118769592,"asset_id":124568823,"asset_type":"Work","always_allow_download":false,"scribd_thumbnail_url":"https://attachments.academia-assets.com/118769592/thumbnails/1.jpg","download_url":"https://d1wqtxts1xzle7.cloudfront.net/118769592/ppd_article-libre.pdf?1728475291=\u0026response-content-disposition=attachment%3B+filename%3DPOSTPARTUM_MOOD_DISORDERS_A_THREAT_TO_NE.pdf\u0026Expires=1741108891\u0026Signature=gZV7EjfHUTgLS~j7YVj2rrN2GvYQQTmDD1Srzl3vWNKtUhU1DkKGKgGcucqLw1Ajb87bipRaT0eC4l~RQgD-k7FAIEsBQ0AtEkgNm6OeL8WU9Rhi9ajFGMevAxZ0VqsVbRlegCT1k4CLARiYOjxUY1LqoMRXrUkkqy81HmlGLW4bIWT1d17dIqfUoYbRJtoK1nOdoyDoPl8y4nWsT6b9h1eOhdJSJT0YluKCaJKGA2kwXghZtlVdMkoCS5zUHndX8hHzcXGAYWRdUJDrLKwgnABwNdugvw8KKqQYnNS-LaRRmk3~L5cCGYGDqC--zufRpf-mtWB3rOWTcS8V7JXa~g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA","download_file_url":"https://www.academia.edu/attachments/118769592/download_file?st=MTc0MTEwNTI5Miw4LjIyMi4yMDguMTQ2&","full_thumbnail_url":"https://0.academia-photos.com/attachment_thumbnails/118769592/mini_magick20241009-1-v8yy9f.png?1728472834"}],"has_pdf":true,"has_fulltext":true,"page_count":8,"ordered_authors":[{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}],"research_interests":[{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}],"publication_year":2023,"publication_year_with_fallback":2023,"paper_rank":null,"all_time_views":10,"active_discussion":{}}, }) } })();</script></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_124568888" data-work_id="124568888" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/124568888/IN_VITRO_DRUG_RELEASE_PROFILE_OF_ACECLOFENAC_NIOSOMES_FORMED_WITH_DIFFERENT_RATIOS_OF_CHOLESTEROL_USING_SORBITAN_ESTERS">IN VITRO DRUG RELEASE PROFILE OF ACECLOFENAC NIOSOMES FORMED WITH DIFFERENT RATIO'S OF CHOLESTEROL USING SORBITAN ESTERS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">Niosomes are non-ionic surfactant vesicles are microscopic lamellar structures formed on the admixture of non-ionic surfactant of alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media.... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_124568888" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">Niosomes are non-ionic surfactant vesicles are microscopic lamellar structures formed on the admixture of non-ionic surfactant of alkyl or dialkyl polyglycerol ether class and cholesterol with subsequent hydration in aqueous media. Niosomes were formed using sorbitan esters (span 20, 40, 60 and 80) and cholesterol in different molar ratios. Acelofenac niosomes are formed using ether injection method. The so formed niosomes were evaluated for their in-vitro drug release and the best formulation with sustained drug release was formed with span-60. The mechanism of drug release was governed by peppas.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/124568888" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="efe57ef1cbf6f6e83c8fccbcd384750e" rel="nofollow" data-download="{"attachment_id":118769652,"asset_id":124568888,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/118769652/download_file?st=MTc0MTEwNTI5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_124568888 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="124568888"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 124568888, container: ".js-paper-rank-work_124568888", }); });</script></li><li class="js-percentile-work_124568888 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124568888; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_124568888"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_124568888 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="124568888"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124568888; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124568888]").text(description); $(".js-view-count-work_124568888").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_124568888").removeClass('hidden') })</script></div></li></ul></li></ul></div></div><div class="u-borderBottom1 u-borderColorGrayLighter"><div class="clearfix u-pv7x u-mb0x js-work-card work_124568968" data-work_id="124568968" itemscope="itemscope" itemtype="https://schema.org/ScholarlyArticle"><div class="header"><div class="title u-fontSerif u-fs22 u-lineHeight1_3"><a class="u-tcGrayDarkest js-work-link" href="https://www.academia.edu/124568968/International_Journal_for_Pharmaceutical_Research_Scholars_IJPRS">International Journal for Pharmaceutical Research Scholars (IJPRS</a></div></div><div class="u-pb4x u-mt3x"><div class="summary u-fs14 u-fw300 u-lineHeight1_5 u-tcGrayDarkest"><div class="summarized">The aim of the present work was to develop colon specific drug delivery system for Diltiazem using natural polymers as carriers. We have investigated colon specific, pulsatile device to achieve time and site specific release of Diltiazem... <a class="more_link u-tcGrayDark u-linkUnstyled" data-container=".work_124568968" data-show=".complete" data-hide=".summarized" data-more-link-behavior="true" href="#">more</a></div><div class="complete hidden">The aim of the present work was to develop colon specific drug delivery system for Diltiazem using natural polymers as carriers. We have investigated colon specific, pulsatile device to achieve time and site specific release of Diltiazem based on chronopharmaceutical considerations. The basic design consists of an insoluble hard gelatin capsule body, filled with Diltiazem surface solid dispersions and sealed with guar gum hydrogel plug. The entire capsule was coated with ethyl cellulose, so that the variability in gastric emptying time can be overcome and a colon specific release can be achieved. Surface solid dispersions (SSDs) of Diltiazem were prepared using natural polymers such as Guar gum (GG), sodium alginate and Xanthan gum (XG) in the weight ratios of 1:2,1:4 and 1:6 by using emulsification solvent evaporation method. Physicochemical properties of the prepared SSD were characterized by FTIR and SEM. Optimized SSD were obtained by practical yield, drug content, solubility and dissolution studies and were selected for further fabrication of pulsincaps. Guar gum was used as hydrogel plug material to maintain a suitable lag period. The prepared pulsincaps were evaluated for in-vitro release. Pulsincap formulated with Diltiazem : Sodium alginate at 1:2 ratio of surface solid dispersions showed highest drug release over the period of 19 hr and release was found to be Higuchi model kinetics. The present research study results have confirmed that the modified pulsincap of Diltiazem is a suitable device for the time dependent and site specific delivery to the colon segment of GIT.</div></div></div><ul class="InlineList u-ph0x u-fs13"><li class="InlineList-item logged_in_only"><div class="share_on_academia_work_button"><a class="academia_share Button Button--inverseBlue Button--sm js-bookmark-button" data-academia-share="Work/124568968" data-share-source="work_strip" data-spinner="small_white_hide_contents"><i class="fa fa-plus"></i><span class="work-strip-link-text u-ml1x" data-content="button_text">Bookmark</span></a></div></li><li class="InlineList-item"><div class="download"><a id="95a0b211ae098bdcd3ba195d76be88a1" rel="nofollow" data-download="{"attachment_id":118769724,"asset_id":124568968,"asset_type":"Work","always_allow_download":false,"track":null,"button_location":"work_strip","source":null,"hide_modal":null}" class="Button Button--sm Button--inverseGreen js-download-button prompt_button doc_download" href="https://www.academia.edu/attachments/118769724/download_file?st=MTc0MTEwNTI5Miw4LjIyMi4yMDguMTQ2&s=work_strip"><i class="fa fa-arrow-circle-o-down fa-lg"></i><span class="u-textUppercase u-ml1x" data-content="button_text">Download</span></a></div></li><li class="InlineList-item"><ul class="InlineList InlineList--bordered u-ph0x"><li class="InlineList-item InlineList-item--bordered"><span class="InlineList-item-text">by <span itemscope="itemscope" itemprop="author" itemtype="https://schema.org/Person"><a class="u-tcGrayDark u-fw700" data-has-card-for-user="229895351" href="https://jntua.academia.edu/DrDivyadivya">Dr. Divya Budarapu</a><script data-card-contents-for-user="229895351" type="text/json">{"id":229895351,"first_name":"Dr. Divya","last_name":"Budarapu","domain_name":"jntua","page_name":"DrDivyadivya","display_name":"Dr. Divya Budarapu","profile_url":"https://jntua.academia.edu/DrDivyadivya","photo":"https://0.academia-photos.com/229895351/86466008/104493985/s65_divya.budarapu.jpg"}</script></span></span></li><li class="js-paper-rank-work_124568968 InlineList-item InlineList-item--bordered hidden"><span class="js-paper-rank-view hidden u-tcGrayDark" data-paper-rank-work-id="124568968"><i class="u-m1x fa fa-bar-chart"></i><strong class="js-paper-rank"></strong></span><script>$(function() { new Works.PaperRankView({ workId: 124568968, container: ".js-paper-rank-work_124568968", }); });</script></li><li class="js-percentile-work_124568968 InlineList-item InlineList-item--bordered hidden u-tcGrayDark"><span class="percentile-widget hidden"><span class="u-mr2x percentile-widget" style="display: none">•</span><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 124568968; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-percentile-work_124568968"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></li><li class="js-view-count-work_124568968 InlineList-item InlineList-item--bordered hidden"><div><span><span class="js-view-count view-count u-mr2x" data-work-id="124568968"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 124568968; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=124568968]").text(description); $(".js-view-count-work_124568968").attr('title', description).tooltip(); }); });</script></span><script>$(function() { $(".js-view-count-work_124568968").removeClass('hidden') })</script></div></li><li class="InlineList-item u-positionRelative" style="max-width: 250px"><div class="u-positionAbsolute" data-has-card-for-ri-list="124568968"><i class="fa fa-tag InlineList-item-icon u-positionRelative"></i></div><span class="InlineList-item-text u-textTruncate u-pl6x"><a class="InlineList-item-text" data-has-card-for-ri="656" rel="nofollow" href="https://www.academia.edu/Documents/in/Pharmacy">Pharmacy</a><script data-card-contents-for-ri="656" type="text/json">{"id":656,"name":"Pharmacy","url":"https://www.academia.edu/Documents/in/Pharmacy","nofollow":true}</script></span></li><script>(function(){ if (false) { new Aedu.ResearchInterestListCard({ el: $('*[data-has-card-for-ri-list=124568968]'), work: {"id":124568968,"title":"International Journal for Pharmaceutical Research Scholars (IJPRS","created_at":"2024-10-09T04:26:53.603-07:00","owner_id":229895351,"url":"https://www.academia.edu/124568968/International_Journal_for_Pharmaceutical_Research_Scholars_IJPRS","slug":"International_Journal_for_Pharmaceutical_Research_Scholars_IJPRS","dom_id":"work_124568968","summary":"The aim of the present work was to develop colon specific drug delivery system for Diltiazem using natural polymers as carriers. 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Guar gum was used as hydrogel plug material to maintain a suitable lag period. The prepared pulsincaps were evaluated for in-vitro release. Pulsincap formulated with Diltiazem : Sodium alginate at 1:2 ratio of surface solid dispersions showed highest drug release over the period of 19 hr and release was found to be Higuchi model kinetics. 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