Collagen and the effect of poly-l-lactic acid based materials on its synthesis

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Eng., C; citation_volume=69; citation_pages=437-446;citation_publication_date=2016; " /> <meta name="citation_reference" content="citation_title= et al., Composite poly-L-lactic acid/poly-(α, β)-DL-aspartic acid/collagen nanofibrous scaffolds for dermal tissue regeneration; citation_author=R. Ravichandran; citation_journal_title=Mater. Sci. Eng., C; citation_volume=32; citation_pages=1443-1451;citation_publication_date=2012; " /> <meta content=" Collagen is an important protein in various biological functions such as providing elasticity and waterproofing to the skin, structural stability to the cells in connective tissues (e.g. tendons, and bone) and stabilisation of atherosclerotic plaques. Collagen as a peptide with a peculiar triple helical structure is majorly composed of glycine and proline amino acids and is synthesised by fibroblasts via intracellular and extracellular mechanisms. Collagen plays an important role in wound healing, bone repair and plaque build-up during atherosclerosis. Various factors such as interleukins, insulin-like growth factor-I, nicotine, and glucose have been shown to influence collagen synthesis. This paper provides an overview of collagen structure, synthesis mechanisms, and the parameters that stimulate those mechanisms. Poly-L-lactic acid as a well-known biocompatible and biodegradable polymer has proved to stimulate collagen synthesis in various physical forms. As such, in this review special emphasis is laid on the effects of poly-L-lactic acid as well as its mechanism of action on collagen synthesis. 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Click to view all articles in this issue." title="Issue 17, 2021">Issue 17, 2021</a> </div> <nav aria-label="Article"> <ul class="article-nav__bar"> <li> <a href="/en/Content/ArticleLanding/2021/BM/D1BM90079J"> Previous <span class="v-mobile-hide--inline">Article</span> </a> </li> <li> <a href="/en/Content/ArticleLanding/2021/BM/D1BM00634G"> Next <span class="v-mobile-hide--inline">Article</span> </a> </li> </ul> </nav> <div class="list-control"> <div class="list__collection--image"> <div class="list__item"> <a href="/en/journals/journal/bm" class="list__item-link"> <div class="list__image-col"> <img src="/en/Image/Get?imageInfo.ImageType=CoverIssue&imageInfo.ImageIdentifier.SerCode=BM&imageInfo.ImageIdentifier.IssueId=BM009017" id="imgLoader" alt="" class="list__item-img" height="88"> </div> <div class="list__text-col"> <div class="list__item-label"> <span class="page-head__context">From the journal:</span> <h3 class="h--heading3 no-heading">Biomaterials Science</h3> </div> </div> </a> </div> </div> </div> <br> </div> <article class="article-control"> <div class="article__title"> <h2 class="capsule__title fixpadv--m"> Collagen and the effect of poly-<span class="small-caps">l</span>-lactic acid based materials on its synthesis </h2> <div class="fixpadv--m crossmark-button"> <button type="button" data-target="crossmark"><img width="150" height="32" src="https://crossmark-cdn.crossref.org/widget/v2.0/logos/CROSSMARK_Color_horizontal.svg" alt="Check for updates" /></button> </div> </div> <div class="article__authors"> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3ASubarna%20Ray">Subarna Ray</a>,<a href="#fn1" title="These authors contributed equally.">†</a><span><sup><i>a</i></sup></span>   </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AHossein%20Adelnia">Hossein Adelnia</a><a href="#fn1" title="These authors contributed equally.">†</a><span><sup><i>ab</i></sup></span>  and  </span> <span class="article__author-link"> <a href="/en/results?searchtext=Author%3AHang%20T.%20Ta">Hang T. Ta</a> <span class="orcid ver-b"><a target="_blank" title="Select to open ORCID record for Hang T. Ta (orcid.org/0000-0003-1188-0472) in a new window" href="https://orcid.org/0000-0003-1188-0472"><img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/orcid_16x16.png" alt="ORCID logo"></a></span> *<span><sup><i>abc</i></sup></span>   </span> </div> <div class="drawer-control fixpadv--m"> <a href="#" role="button" id="btnAuthorAffiliations" aria-expanded="false" aria-controls="pnlAuthorAffiliations" class="drawer__handle"> <span class="drawer__icon"></span> Author affiliations </a> <div class="drawer__content" id="pnlAuthorAffiliations" aria-labelledby="btnAuthorAffiliations"> <div> <p class="article__author-affiliation"> <span> * </span> <span> Corresponding authors </span> </p> <p class="article__author-affiliation"> <span> <sup>a</sup> </span> <span> Queensland Micro- and Nanotechnology Centre, Griffith University, Brisbane, Queensland, Australia <br /> <b>E-mail:</b> <a href="mailto:h.ta@griffith.edu.au" title="h.ta@griffith.edu.au">h.ta@griffith.edu.au</a> </span> </p> <p class="article__author-affiliation"> <span> <sup>b</sup> </span> <span> Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Brisbane, Queensland, Australia </span> </p> <p class="article__author-affiliation"> <span> <sup>c</sup> </span> <span> School of Environment and Science, Griffith University, Brisbane, Queensland, Australia </span> </p> </div> </div> </div> <h3 class="h--heading3 article-abstract__heading">Abstract</h3> <div class="capsule__column-wrapper"> <div class="capsule__text"> <p xmlns="http://www.rsc.org/schema/rscart38">Collagen is an important protein in various biological functions such as providing elasticity and waterproofing to the skin, structural stability to the cells in connective tissues (<em>e.g.</em> tendons, and bone) and stabilisation of atherosclerotic plaques. Collagen as a peptide with a peculiar triple helical structure is majorly composed of glycine and proline amino acids and is synthesised by fibroblasts <em>via</em> intracellular and extracellular mechanisms. Collagen plays an important role in wound healing, bone repair and plaque build-up during atherosclerosis. Various factors such as interleukins, insulin-like growth factor-I, nicotine, and glucose have been shown to influence collagen synthesis. This paper provides an overview of collagen structure, synthesis mechanisms, and the parameters that stimulate those mechanisms. Poly-<small>L</small>-lactic acid as a well-known biocompatible and biodegradable polymer has proved to stimulate collagen synthesis in various physical forms. As such, in this review special emphasis is laid on the effects of poly-<small>L</small>-lactic acid as well as its mechanism of action on collagen synthesis.</p> </div> <div class="capsule__article-image fixpadv--s"> <img src="/en/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=D1BM00516B&imageInfo.ImageIdentifier.Year=2021" alt="Graphical abstract: Collagen and the effect of poly-l-lactic acid based materials on its synthesis" /> </div> </div> <p></p> <div id="pnlArticleAccess" class="article-access fixpadt--xxl" style="display: none; border: 0;"> <div class="article-access__inner" style="background-color: #F1F1F3;"> <div class="article-access__head fixpad--s"> You have access to this article </div> <div class="fixpad--xl"> <div id="pnlViewFullArticleButton" class="paywall__body text--centered"> <div id="pnlArticleLoading"> <span id="thtmlLoadingMessage"> <img src="https://www.rsc-cdn.org/pubs-core/2022.0.159/content/NewImages/Ajax-GA-Loader.gif" alt="" class="ver-m" /> Please wait while we load your content... </span> <span id="thtmlErrorMessage" style="display: none;"> Something went wrong. <a href="#" id="btnTryAgain">Try again?</a> </span> </div> </div> </div> </div> </div> <div id="pnlArticleContent" class="t-html"> <div id="pnlArticleContentLoaded"> </div> </div> </article> </section> </div> <div class="layout__panel layout__panel--secondary layout__panel--40 layout__panel--filled"> <section class="layout__content"> <input id="contentType" name="contentType" type="hidden" value="" /> <div class="tab-control"> <div class="tab__nav" role="tablist" aria-label="Article"> <div class="tab__item" role="none"> <a href="#pnlAbstract" class="tab__btn selected" role="tab" id="btnAbstract" aria-selected="true" aria-controls="pnlAbstract">About</a> </div> <div class="tab__item" role="none"> <a href="#pnlCitation" class="tab__btn" role="tab" id="btnCitation" aria-selected="false" aria-controls="pnlCitation">Cited by</a> </div> <div class="tab__item" role="none"> <a href="#pnlRelatedContent" class="tab__btn" role="tab" id="btnRelatedContent" aria-selected="false" aria-controls="pnlRelatedContent">Related</a> </div> </div> <div class="tab__panel open" role="tabpanel" id="pnlAbstract" aria-hidden="false" aria-labelledby="btnAbstract" data-loaded="true"> <div class="fixpadv--m"> <div id="divAbout"> <div id="DownloadOption" class="autopad--h fixpadv--l" style="min-height: 150px;"> <div class="text--centered"> <a href="#" class="btn btn--cta btn--disabled btn--block btn--stack btn-icon btn-icon--loading"> Download options <span class="btn-info">Please wait...</span> </a> </div> </div> <div class="autopad--h"> <h2 class="h--heading3">Article information</h2> <dl class="definition-list"> <div class="c doi-link"> <dt class="sr-only">DOI</dt> <dd class="c__24"><a class="text--small" title="Link to landing page via DOI" href="https://doi.org/10.1039/D1BM00516B">https://doi.org/10.1039/D1BM00516B</a></dd> </div> <div class="c fixpadt--l line-separator"> <dt class="c__10"><strong>Article type</strong></dt> <dd class="c__14">Review Article</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">Submitted</dt> <dd class="c__14">01 Apr 2021</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">Accepted</dt> <dd class="c__14">28 Jun 2021</dd> </div> <div class="c fixpadt--l"> <dt class="c__10">First published</dt> <dd class="c__14">29 Jun 2021</dd> </div> </dl> <div class="c fixpadt--l line-separator"> <div class="c__10"> <h3 class="definition-label"> <label for="ResultAbstractFormat"><span class="sr-only">Download</span> Citation</label> </h3> </div> <div class="c__14"> <i><strong>Biomater. 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Collagen and the effect of poly-l-lactic acid based materials on its synthesis - Biomaterials Science (RSC Publishing)