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Scott Kogan, MD | UCSF Helen Diller Family Comprehensive Cancer Center
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Kogan, MD </h1> <strong> <p>Professor, Department of Laboratory Medicine, UCSF</p> </strong> <div class="people-callout__memberships"> <h2 class="people-callout__memberships-title">Cancer Center Program Membership</h2> <a href="/research/programs/cancer-immunology-hematology">Cancer Immunology & Immunotherapy</a> </div> </div> </div> <div class="column-4 sidebar last"> <div class="widget widget--people-details"> <div class="widget__content"> <p> <strong>Phone:</strong> <a href="tel:%28415%29514-1590%28voice%29">(415) 514-1590 (voice)</a> </p> <div class="field field-address-postal field--type-address field--label-hidden field__item"> <p class="address" translate="no"> Box 0100, UCSF <br> San Francisco, CA 94143-0100 </p> </div> <a href="https://www.ucsfhealth.org/providers/dr-scott-kogan" class="button button--dark-blue" target="_blank"> Physician Biography </a> <p> <a class="button button--dark-blue" href="https://profiles.ucsf.edu/scott.kogan"> UCSF Profiles </a> </p> </div> </div> </div> </article> </div> </div> </div> </div> </div> <div class="views-element-container block block-views block-views-blockperson-header-person-tabs-block" id="block-views-block-person-header-tabs-block"> <div block="block-views-block-person-header-tabs-block" region="content_header"><div class="view view-person-header view-id-person_header view-display-id-person_tabs_block js-view-dom-id-51d724155ee6e78d0ca3a89f58a85e843cf0dbacad0f02df2ce7bcf01c1b7453"> <div class="view-content"> <div class="views-row"> <section about="/people/kogan.scott" class="node node--type-kanopi-ucsf-person node--view-mode-default"> <div class="profile-tabs"> <div class="profile-tab-nav"> <ul> <li><a href="#research" class="active">Research</a></li> <li><a href="#education">Training</a></li> <li><a href="#honors">Awards</a></li> <li><a href="#publications">Publications</a></li> </ul> </div> </div> </section> </div> </div> </div> </div> </div> </section> </div> <a id="main-content" tabindex="-1"></a> <div class="column-8 content"> <div id="block-mainpagecontent" class="block block-system block-system-main-block"> <article about="/people/kogan.scott" class="node node--type-kanopi-ucsf-person node--view-mode-full"> <div class="node__content content"> <div class="column-8 content"> <div class="profile-tab-container"> <div class="profile-tab profile-tab-active" id="research"> <div class="profile-tab-item"> <h3>Research Summary</h3> <p>I am a Professor in the Department of Laboratory Medicine and the Helen Diller Family Comprehensive Cancer Center at the University of California San Francisco. I am a board-certified hematopathologist with 24 years in active practice diagnosing lymphomas, leukemias, and other hematologic disorders. As a past chair of the Hematopathology subcommittee of the National Cancer Institute鈥檚 Mouse Models of Human Cancers Consortium, I am an internationally recognized expert in the characterization and classification of hematopoietic neoplasms in mice as well as in humans. I am also a noted researcher in the molecular pathogenesis of leukemia, including in the initiation of leukemia by genetic changes. My hematopathology training and research background combine to facilitate consultations and collaborations with investigators at UCSF, nationally, and internationally. I use my expertise and experience in pathology and laboratory medicine to direct the Histology and Biomarker Core of the UCSF HDFCCC.</p> </div> <div class="profile-tab-item"> <h3>Research Funding</h3> <ul class="list-no-disc"> <li><div> June 1, 2014 - May 31, 2020 - Impact of low IL-10 levels at birth and leukemia risk , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA185058</div></li> <li><div> September 25, 2009 - June 30, 2019 - Center for Integrative Research on Childhood Leukemia and the Environment , Co-Investigator . Sponsor: NIH, Sponsor Award ID: P50ES018172</div></li> <li><div> February 1, 2013 - January 31, 2016 - Impact of B-Cell Lineage on Progression of B-Acute Lymphoblastic Leukemia , Co-Principal Investigator . Sponsor: NIH, Sponsor Award ID: R21CA173028</div></li> <li><div> April 1, 2002 - January 31, 2014 - Molecular Mechanisms of Leukemogenesis by PMLRAR alpha , Principal Investigator . Sponsor: NIH, Sponsor Award ID: R01CA095274</div></li> </ul> </div> </div> <div class="profile-tab" id="education"> <h3>Education</h3> <p>Harvard College, Cambridge, MA, A.B., 1986, Biochemical Sciences<br /> University of California San Francisco, M.D., 1991, Medicine<br /> Laboratory Medicine Residency, UCSF, 1991-1993, Laboratory Medicine<br /> Hematopathology Fellowship, UCSF, 1997-1998, Hematopathology</p> </div> <div class="profile-tab" id="honors"> <h3>Honors & Awards</h3> <ul> <li>1986<br /> Summa Cum Laude, Phi Beta Kappa</li> <li>1986<br /> Joseph L. Barrett Award for Teaching, Harvard University</li> <li>1993<br /> National Committee for Clinical Laboratory Standards, Honored Graduate Award</li> <li>1993<br /> UCSF Molecular Medicine Training Program</li> <li>1993<br /> American Cancer Society Physician Research Training Award</li> <li>1994<br /> Howard Hughes Medical Institute Postdoctoral Research Fellowship for Physicians</li> <li>1997<br /> Burroughs Wellcome Fund Career Award</li> <li>2000<br /> 32nd Edward Mallinckrodt Jr. Scholar Award</li> <li>2001<br /> Medical Student Teaching Award, Excellence for Small Group Instruction</li> <li>2002<br /> Department of Laboratory Medicine Resident Teaching Award</li> <li>2004<br /> Leukemia & Lymphoma Society Scholar Award</li> <li>2007<br /> Mentor Award, UCSF Department of Pediatrics</li> </ul> </div> <div class="profile-tab" id="publications"> <h3>Selected Publications</h3> <ol> <li> Zhong C, Li S, Arroyo K, Morimoto LM, de Smith AJ, Metayer C, Ma X, Kogan SC, Gauderman WJ, Wiemels JL. Gene-environment analyses reveal novel genetic candidates with prenatal tobacco exposure in relation to risk for childhood acute lymphoblastic leukemia. Cancer Epidemiol Biomarkers Prev. 2023 Sep 29. <a href="https://pubmed.ncbi.nlm.nih.gov/37773025" target="_blank">View on PubMed</a> </li> <li> Mas G, Man N, Nakata Y, Martinez-Caja C, Karl D, Beckedorff F, Tamiro F, Chen C, Duffort S, Itonaga H, Mookhtiar AK, Kunkalla K, Valencia AM, Collings CK, Kadoch C, Vega F, Kogan SC, Morey L, Bilbao D, Nimer SD. The SWI/SNF chromatin-remodeling subunit DPF2 facilitates NRF2-dependent antiinflammatory and antioxidant gene expression. J Clin Invest. 2023 07 03; 133(13). <a href="https://pubmed.ncbi.nlm.nih.gov/37200093" target="_blank">View on PubMed</a> </li> <li> Fitch BA, Situ J, Wiemels JL, Kogan SC, Zhou M. Impact of pinworm infection on the development of murine B-cell leukemia/lymphoma in the presence and absence of ETV6::RUNX1. Haematologica. 2023 Jun 22. <a href="https://pubmed.ncbi.nlm.nih.gov/37345483" target="_blank">View on PubMed</a> </li> <li> Hu Y, Geere M, Awan M, Leavitt AD, Brown LE, Pearson HJ, Gandelman JS, Kogan SC. Dapsone-induced methemoglobinemia and hemolysis in a woman without G6PD deficiency presenting with idiopathic urticaria. Hematology. 2022 Dec; 27(1):1253-1258. <a href="https://pubmed.ncbi.nlm.nih.gov/36444994" target="_blank">View on PubMed</a> </li> <li> Wiemels JL, Wang R, Zhou M, Hansen H, Gallant R, Jung J, Mancuso N, De Smith AJ, Metayer C, Kogan SC, Ma X. Cytomegalovirus proteins, maternal pregnancy cytokines, and their impact on neonatal immune cytokine profiles and acute lymphoblastic leukemogenesis in children. Haematologica. 2022 09 01; 107(9):2266-2270. <a href="https://pubmed.ncbi.nlm.nih.gov/35638549" target="_blank">View on PubMed</a> </li> <li> Carnevale J, Shifrut E, Kale N, Nyberg WA, Blaeschke F, Chen YY, Li Z, Bapat SP, Diolaiti ME, O'Leary P, Vedova S, Belk J, Daniel B, Roth TL, Bachl S, Anido AA, Prinzing B, Iba帽ez-Vega J, Lange S, Haydar D, Luetke-Eversloh M, Born-Bony M, Hegde B, Kogan S, Feuchtinger T, Okada H, Satpathy AT, Shannon K, Gottschalk S, Eyquem J, Krenciute G, Ashworth A, Marson A. RASA2 ablation in T cells boosts antigen sensitivity and long-term function. Nature. 2022 09; 609(7925):174-182. <a href="https://pubmed.ncbi.nlm.nih.gov/36002574" target="_blank">View on PubMed</a> </li> <li> Qi Z, Wen KW, Ki A, Prakash S, Kogan S, Yu J. Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia. Cytogenet Genome Res. 2022; 162(3):119-123. <a href="https://pubmed.ncbi.nlm.nih.gov/35675801" target="_blank">View on PubMed</a> </li> <li> Alveena Thomas, Margaret C. Fang, Scott Kogan, Colin C. Hubbard, Paula N. Friedman, Li Gong, Teri E. Klein, Edith A. Nutescu, Travis J. O'Brien, Matthew Tuck, Minoli A. Perera, Janice B. Schwartz. Apixaban Concentrations in Routine Clinical Care of Older Adults With Nonvalvular Atrial Fibrillation. JACC Advances. 2022 Jun 1; 1(2):100039. <a href="https://pubmed.ncbi.nlm.nih.gov/" target="_blank">View on PubMed</a> </li> <li> Gallant RE, Arroyo K, Bracci PM, Li S, Metayer C, Kogan SC, Wendt GA, Francis SS, de Smith AJ, Wiemels JL. Clinical characteristics of cytomegalovirus-positive pediatric acute lymphoblastic leukemia at diagnosis. Am J Hematol. 2022 06 01; 97(6):E198-E201. <a href="https://pubmed.ncbi.nlm.nih.gov/35285969" target="_blank">View on PubMed</a> </li> <li> Fitch BA, Zhou M, Situ J, Surianarayanan S, Reeves MQ, Hermiston ML, Wiemels JL, Kogan SC. Decreased IL-10 accelerates B-cell leukemia/lymphoma in a mouse model of pediatric lymphoid leukemia. Blood Adv. 2022 01 08; 6(3):854-865. <a href="https://pubmed.ncbi.nlm.nih.gov/34727170" target="_blank">View on PubMed</a> </li> <li> Schwartz JB, Kogan SC, Fang MC. Preventing Bleeding With Direct-Acting Oral Anticoagulants. J Am Coll Cardiol. 2021 10 19; 78(16):e127. <a href="https://pubmed.ncbi.nlm.nih.gov/34649705" target="_blank">View on PubMed</a> </li> <li> Morales CE, Stieglitz E, Kogan SC, Loh ML, Braun BS. Nf1 and Sh2b3 mutations cooperate in vivo in a mouse model of juvenile myelomonocytic leukemia. 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Anti-factor Xa activity assays of direct-acting oral anticoagulants during clinical care: An observational study. Res Pract Thromb Haemost. 2021 May; 5(4):e12528. <a href="https://pubmed.ncbi.nlm.nih.gov/34013157" target="_blank">View on PubMed</a> </li> <li> Snijders AM, Zhou M, Whitehead TP, Fitch B, Pandey P, Hechmer A, Huang A, Schick SF, de Smith AJ, Olshen AB, Metayer C, Mao JH, Wiemels JL, Kogan SC. In utero and early-life exposure to thirdhand smoke causes profound changes to the immune system. Clin Sci (Lond). 2021 04 30; 135(8):1053-1063. <a href="https://pubmed.ncbi.nlm.nih.gov/33851706" target="_blank">View on PubMed</a> </li> <li> Feng Q, de Smith AJ, Vergara-Lluri M, Muskens IS, McKean-Cowdin R, Kogan S, Brynes R, Wiemels JL. Trends in Acute Lymphoblastic Leukemia Incidence in the United States by Race/Ethnicity From 2000 to 2016. Am J Epidemiol. 2021 04 06; 190(4):519-527. <a href="https://pubmed.ncbi.nlm.nih.gov/33034340" target="_blank">View on PubMed</a> </li> <li> Kogan SC. PML-RAR伪: changing myeloid networks. Blood. 2021 03 18; 137(11):1439-1440. <a href="https://pubmed.ncbi.nlm.nih.gov/33734342" target="_blank">View on PubMed</a> </li> <li> Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, Del Pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales CE, Schanze D, Castel P, Hirose K, Huang GN, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS, Shannon K. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 11 05; 5(21). <a href="https://pubmed.ncbi.nlm.nih.gov/32990679" target="_blank">View on PubMed</a> </li> <li> Gloria Mas Martin, Na Man, Daniel Karl, Concepcion Martinez, Stephanie Duffort, Hidehiro Itonaga, Adnan K Mookhtiar, Daniel Bilbao, Kranthi Kunkalla, Alfredo M Valencia, Clayton Collings, Cigall Kadoch, Francisco Vega, Scott C. Kogan, Stephen Nimer. The Baf Subunit Dpf2 Regulates Resolution of Inflammation By Controlling Macrophage Differentiation Transcription Factor Networks. 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