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Yao</title> <meta name="description" content="Search results for: Yali Yao"> <meta name="keywords" content="Yali Yao"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="Yali Yao"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 8</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: Yali Yao</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">8</span> Visual Search Based Indoor Localization in Low Light via RGB-D Camera</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yali%20Zheng">Yali Zheng</a>, <a href="https://publications.waset.org/abstracts/search?q=Peipei%20Luo"> Peipei Luo</a>, <a href="https://publications.waset.org/abstracts/search?q=Shinan%20Chen"> Shinan Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Jiasheng%20Hao"> Jiasheng Hao</a>, <a href="https://publications.waset.org/abstracts/search?q=Hong%20Cheng"> Hong Cheng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Most of traditional visual indoor navigation algorithms and methods only consider the localization in ordinary daytime, while we focus on the indoor re-localization in low light in the paper. As RGB images are degraded in low light, less discriminative infrared and depth image pairs are taken, as the input, by RGB-D cameras, the most similar candidates, as the output, are searched from databases which is built in the bag-of-word framework. Epipolar constraints can be used to relocalize the query infrared and depth image sequence. We evaluate our method in two datasets captured by Kinect2. The results demonstrate very promising re-localization results for indoor navigation system in low light environments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=indoor%20navigation" title="indoor navigation">indoor navigation</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20light" title=" low light"> low light</a>, <a href="https://publications.waset.org/abstracts/search?q=RGB-D%20camera" title=" RGB-D camera"> RGB-D camera</a>, <a href="https://publications.waset.org/abstracts/search?q=vision%20based" title=" vision based"> vision based</a> </p> <a href="https://publications.waset.org/abstracts/66057/visual-search-based-indoor-localization-in-low-light-via-rgb-d-camera" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66057.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">460</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">7</span> The Influence of Feedgas Ratio on the Ethene Hydroformylation using Rh-Co Bimetallic Catalyst Supported by Reduced Graphene Oxide</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianli%20Chang">Jianli Chang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yusheng%20Zhang"> Yusheng Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Yao"> Yali Yao</a>, <a href="https://publications.waset.org/abstracts/search?q=Diane%20Hildebrandt"> Diane Hildebrandt</a>, <a href="https://publications.waset.org/abstracts/search?q=Xinying%20Liu"> Xinying Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The influence of feed-gas ratio on the ethene hydroformylation over an Rh-Co bimetallic catalyst supported by reduced graphene oxide (RGO) has been investigated in a tubular fixed bed reactor. Argon was used as balance gas when the feed-gas ratio was changed, which can keep the partial pressure of the other two kinds of gas constant while the ratio of one component in feed-gas was changed. First, the effect of single-component gas ratio on the performance of ethene hydroformylation was studied one by one (H₂, C₂H₄ and CO). Then an optimized ratio was found to obtain a high selectivity to C₃ oxygenates. The results showed that: (1) 0.5%Rh-20%Co/RGO is a promising heterogeneous catalyst for ethene hydroformylation. (2) H₂ and CO have a more significant influence than C₂H₄ on selectivity to oxygenates. (3) A lower H₂ ratio and a higher CO ratio in feed-gas can lead to a higher selectivity to oxygenates. (4) The highest selectivity to oxygenates, 61.70%, was obtained at the feed-gas ratio CO: C₂H₄: H₂ = 4: 2: 1. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ethene%20hydroformylation" title="ethene hydroformylation">ethene hydroformylation</a>, <a href="https://publications.waset.org/abstracts/search?q=reduced%20graphene%20oxide" title=" reduced graphene oxide"> reduced graphene oxide</a>, <a href="https://publications.waset.org/abstracts/search?q=rhodium%20cobalt%20bimetallic%20catalyst" title=" rhodium cobalt bimetallic catalyst"> rhodium cobalt bimetallic catalyst</a>, <a href="https://publications.waset.org/abstracts/search?q=the%20effect%20of%20feed-gas%20ratio" title=" the effect of feed-gas ratio"> the effect of feed-gas ratio</a> </p> <a href="https://publications.waset.org/abstracts/146368/the-influence-of-feedgas-ratio-on-the-ethene-hydroformylation-using-rh-co-bimetallic-catalyst-supported-by-reduced-graphene-oxide" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/146368.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">6</span> Messiness and Strategies for Elite Interview: Multi-Sited Ethnographic Research in Mainland China</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yali%20Liu">Yali Liu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The ethnographic research involved a multi-sited field trip study in China to compile in-depth data from Chinese multilingual academics of Korean, Japanese, and Russian. It aimed to create a culturally-informed portrait of their values and perceptions regarding their choice of language for academic publishing. Extended and lengthy fieldwork, or known as ‘deep hanging out’, enabled the author to gain a comprehensive understanding of the research context at the macro-level and the participants’ experiences at the micro-level. This research involved multiple fieldwork sites, which the author selected in acknowledgment of the diversity in China’s regions with respect to their geopolitical context, socio-economic development, cultural traditions, and administrative status. The 14 weeks of data collection took the author over-land to five regions in northern China: Hebei province, Tianjin, Jilin province, Gansu province, and Xinjiang. Responding to the fieldwork dynamics, the author positioned herself at different degrees of insiderness and outsiderness. This occurred at three levels: the regional level, the individual level, and the within-individual level. To enhance the ability to reflect on the authors’ researcher subjectivity, the author explored her understanding of the five ‘I’s, derived from the authors’ natural attributes. This helped the author to monitor her subjectivity, particularly during critical decision-making. The methodological challenges the author navigated were related to interviewing elites; this involved the initial approach, establishing a relationship, and negotiating the unequal power relationship during our contact. The author developed a number of strategies to strengthen her authority, and to gain the confidence of her envisaged participants and secure their collaboration, and the author negotiated a form of reciprocity that reflected their needs and expectations. The current ethnographic research has both theoretical and practical significance. It contributes to the methodological development regarding multi-sited ethnographic research. The messiness and strategies about positioning and interviewing elites will provide practical lessons for researchers who conduct ethnographic research, especially from power-‘less’ positions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=multi-sited%20ethnographic%20research" title="multi-sited ethnographic research">multi-sited ethnographic research</a>, <a href="https://publications.waset.org/abstracts/search?q=elite%20interview" title=" elite interview"> elite interview</a>, <a href="https://publications.waset.org/abstracts/search?q=multilingual%20China" title=" multilingual China"> multilingual China</a>, <a href="https://publications.waset.org/abstracts/search?q=subjectivity" title=" subjectivity"> subjectivity</a>, <a href="https://publications.waset.org/abstracts/search?q=reciprocity" title=" reciprocity"> reciprocity</a> </p> <a href="https://publications.waset.org/abstracts/117628/messiness-and-strategies-for-elite-interview-multi-sited-ethnographic-research-in-mainland-china" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/117628.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">110</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">5</span> A Description Analysis of Mortality Rate of Human Infection with Avian Influenza A(H7N9) Virus in China</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lei%20Zhou">Lei Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Chao%20Li"> Chao Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruiqi%20Ren"> Ruiqi Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Dan%20Li"> Dan Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Wang"> Yali Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Daxin%20Ni"> Daxin Ni</a>, <a href="https://publications.waset.org/abstracts/search?q=Zijian%20Feng"> Zijian Feng</a>, <a href="https://publications.waset.org/abstracts/search?q=Qun%20Li"> Qun Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Since the first human infection with avian influenza A(H7N9) case was reported in China on 31 March 2013, five epidemics have been observed in China through February 2013 and September 2017. Though the overall mortality rate of H7N9 has remained as high as around 40% throughout the five epidemics, the specific mortality rate in Mainland China varied by provinces. We conducted a descriptive analysis of mortality rates of H7N9 cases to explore the various severity features of the disease and then to provide clues of further analyses of potential factors associated with the severity of the disease. Methods: The data for analysis originated from the National Notifiable Infectious Disease Report and Surveillance System (NNIDRSS). The surveillance system and identification procedure for H7N9 infection have not changed in China since 2013. The definition of a confirmed H7N9 case is as same as previous reports. Mortality rates of H7N9 cases are described and compared by time and location of reporting, age and sex, and genetic features of H7N9 virus strains. Results: The overall mortality rate, the male and female specific overall rates of H7N9 is 39.6% (608/1533), 40.3% (432/1072) and 38.2% (176/461), respectively. There was no significant difference between the mortality rates of male and female. The age-specific mortality rates are significantly varied by age groups (χ²=38.16, p < 0.001). The mortality of H7N9 cases in the age group between 20 and 60 (33.17%) and age group of over 60 (51.16%) is much higher than that in the age group of under 20 (5.00%). Considering the time of reporting, the mortality rates of cases which were reported in the first (40.57%) and fourth (42.51%) quarters of each year are significantly higher than the mortality of cases which were reported in the second (36.02%) and third (27.27%) quarters (χ²=75.18, p < 0.001). The geographic specific mortality rates vary too. The mortality rates of H7N9 cases reported from the Northeast China (66.67%) and Westeast China (56.52%) are significantly higher than that of H7N9 cases reported from the remained area of mainland China. The mortality rate of H7N9 cases reported from the Central China is the lowest (34.38%). The mortality rates of H7N9 cases reported from rural (37.76%) and urban (38.96%) areas are similar. The mortality rate of H7N9 cases infected with the highly pathogenic avian influenza A(H7N9) virus (48.15%) is higher than the rate of H7N9 cases infected with the low pathogenic avian influenza A(H7N9) virus (37.57%), but the difference is not statistically significant. Preliminary analyses showed that age and some clinical complications such as respiratory failure, heart failure, and septic shock could be potential risk factors associated with the death of H7N9 cases. Conclusions: The mortality rates of H7N9 cases varied by age, sex, time of reporting and geographical location in mainland China. Further in-depth analyses and field investigations of the factors associated with the severity of H7N9 cases need to be considered. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=H7N9%20virus" title="H7N9 virus">H7N9 virus</a>, <a href="https://publications.waset.org/abstracts/search?q=Avian%20Influenza" title=" Avian Influenza"> Avian Influenza</a>, <a href="https://publications.waset.org/abstracts/search?q=mortality" title=" mortality"> mortality</a>, <a href="https://publications.waset.org/abstracts/search?q=China" title=" China"> China</a> </p> <a href="https://publications.waset.org/abstracts/85904/a-description-analysis-of-mortality-rate-of-human-infection-with-avian-influenza-ah7n9-virus-in-china" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85904.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">243</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">4</span> Applying Push Notifications with Behavioral Change Strategies in Fitness Applications: A Survey of User's Perception Based on Consumer Engagement </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yali%20Liu">Yali Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Avello%20Iturriagagoitia"> Maria Avello Iturriagagoitia</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Fitness applications (apps) are one of the most popular mobile health (mHealth) apps. These apps can help prevent/control health issues such as obesity, which is one of the most serious public health challenges in the developed world in recent decades. Compared with the traditional intervention like face-to-face treatment, it is cheaper and more convenient to use fitness apps to interfere with physical activities and healthy behaviors. Nevertheless, fitness applications apps tend to have high abandonment rates and low levels of user engagement. Therefore, maintaining the endurance of users' usage is challenging. In fact, previous research shows a variety of strategies -goal-setting, self-monitoring, coaching, etc.- for promoting fitness and health behavior change. These strategies can influence the users’ perseverance and self-monitoring of the program as well as favoring their adherence to routines that involve a long-term behavioral change. However, commercial fitness apps rarely incorporate these strategies into their design, thus leading to a lack of engagement with the apps. Most of today’s mobile services and brands engage their users proactively via push notifications. Push notifications. These notifications are visual or auditory alerts to inform mobile users about a wide range of topics that entails an effective and personal mean of communication between the app and the user. One of the research purposes of this article is to implement the application of behavior change strategies through push notifications. Proposes: This study aims to better understand the influence that effective use of push notifications combined with the behavioral change strategies will have on users’ engagement with the fitness app. And the secondary objectives are 1) to discuss the sociodemographic differences in utilization of push notifications of fitness apps; 2) to determine the impact of each strategy in customer engagement. Methods: The study uses a combination of the Consumer Engagement Theory and UTAUT2 based model to conduct an online survey among current users of fitness apps. The questionnaire assessed attitudes to each behavioral change strategy, and sociodemographic variables. Findings: Results show the positive effect of push notifications in the generation of consumer engagement and the different impacts of each strategy among different groups of population in customer engagement. Conclusions: Fitness apps with behavior change strategies have a positive impact on increasing users’ usage time and customer engagement. Theoretical experts can participate in designing fitness applications, along with technical designers. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=behavioral%20change" title="behavioral change">behavioral change</a>, <a href="https://publications.waset.org/abstracts/search?q=customer%20engagement" title=" customer engagement"> customer engagement</a>, <a href="https://publications.waset.org/abstracts/search?q=fitness%20app" title=" fitness app"> fitness app</a>, <a href="https://publications.waset.org/abstracts/search?q=push%20notification" title=" push notification"> push notification</a>, <a href="https://publications.waset.org/abstracts/search?q=UTAUT2" title=" UTAUT2"> UTAUT2</a> </p> <a href="https://publications.waset.org/abstracts/121114/applying-push-notifications-with-behavioral-change-strategies-in-fitness-applications-a-survey-of-users-perception-based-on-consumer-engagement" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/121114.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">135</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">3</span> The First Import of Yellow Fever Cases in China and Its Revealing Suggestions for the Control and Prevention of Imported Emerging Diseases</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chao%20Li">Chao Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Zhou"> Lei Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruiqi%20Ren"> Ruiqi Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Dan%20Li"> Dan Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Wang"> Yali Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Daxin%20Ni"> Daxin Ni</a>, <a href="https://publications.waset.org/abstracts/search?q=Zijian%20Feng"> Zijian Feng</a>, <a href="https://publications.waset.org/abstracts/search?q=Qun%20Li"> Qun Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: In 2016, yellow fever had been first ever discovered in China, soon after the yellow fever epidemic occurred in Angola. After the discovery, China had promptly made the national protocol of control and prevention and strengthened the surveillance on passenger and vector. In this study, a descriptive analysis was conducted to summarize China’s experiences of response towards this import epidemic, in the hope of providing experiences on prevention and control of yellow fever and other similar imported infectious diseases in the future. Methods: The imported cases were discovered and reported by General Administration of Quality Supervision, Inspection and Quarantine (AQSIQ) and several hospitals. Each clinically diagnosed yellow fever case was confirmed by real-time reverse transcriptase polymerase chain reaction (RT–PCR). The data of the imported yellow fever cases were collected by local Centers for Disease Control and Prevention (CDC) through field investigations soon after they received the reports. Results: A total of 11 imported cases from Angola were reported in China, during Angola’s yellow fever outbreak. Six cases were discovered by the AQSIQ, among which two with mild symptom were initiative declarations at the time of entry. Except for one death, the remaining 10 cases all had recovered after timely and proper treatment. All cases are Chinese, and lived in Luanda, the capital of Angola. 73% were retailers (8/11) from Fuqing city in Fujian province, and the other three were labors send by companies. 10 cases had experiences of medical treatment in Luanda after onset, among which 8 cases visited the same local Chinese medicine hospital (China Railway four Bureau Hospital). Among the 11 cases, only one case had an effective vaccination. The result of emergency surveillance for mosquito density showed that only 14 containers of water were found positive around places of three cases, and the Breteau Index is 15. Conclusions: Effective response was taken to control and prevent the outbreak of yellow fever in China after discovering the imported cases. However, though the similar origin of Chinese in Angola has provided an easy access for disease detection, information sharing, health education and vaccination on yellow fever; these conveniences were overlooked during previous disease prevention methods. Besides, only one case having effective vaccination revealed the inadequate capacity of immunization service in China. These findings will provide suggestions to improve China’s capacity to deal with not only yellow fever but also other similar imported diseases in China. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=yellow%20fever" title="yellow fever">yellow fever</a>, <a href="https://publications.waset.org/abstracts/search?q=first%20import" title=" first import"> first import</a>, <a href="https://publications.waset.org/abstracts/search?q=China" title=" China"> China</a>, <a href="https://publications.waset.org/abstracts/search?q=suggestion" title=" suggestion"> suggestion</a> </p> <a href="https://publications.waset.org/abstracts/85916/the-first-import-of-yellow-fever-cases-in-china-and-its-revealing-suggestions-for-the-control-and-prevention-of-imported-emerging-diseases" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85916.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">187</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">2</span> Prevalent Features of Human Infections with Highly Pathogenic Avian Influenza A(H7N9) Virus, China, 2017</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lei%20Zhou">Lei Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Dan%20Li"> Dan Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruiqi%20Ren"> Ruiqi Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Chao%20Li"> Chao Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Wang"> Yali Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Daxin%20Ni"> Daxin Ni</a>, <a href="https://publications.waset.org/abstracts/search?q=Zijian%20Feng"> Zijian Feng</a>, <a href="https://publications.waset.org/abstracts/search?q=Timothy%20M.%20Uyeki"> Timothy M. Uyeki</a>, <a href="https://publications.waset.org/abstracts/search?q=Qun%20Li"> Qun Li</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Since the first human infections with avian influenza A(H7N9) virus were identified in early 2013, 1533 cases of laboratory-confirmed A(H7N9) virus infections were reported and confirmed as of September 13, 2017. The fifth epidemic was defined as starting from September 1, 2016, and the number of A(H7N9) cases has surged since the end of December in 2016. On February 18, 2017, the A(H7N9) cases who were infected with highly pathogenic avian influenza (HPAI) virus was reported from Southern China. The HPAI A(H7N9) cases were identified and then an investigation and analyses were conducted to assess whether disease severity in humans has changed with HPAI A(H7N9) compared with low pathogenic avian influenza (LPAI) A(H7N9) virus infection. Methods: All confirmed cases with A(H7N9) virus infections reported throughout mainland China from September 1, 2016, to September 13, 2017, were included. Cases' information was extracted from field investigation reports and the notifiable infectious surveillance system to describe the demographic, clinical, and epidemiologic characteristics. Descriptive statistics were used to compare HPAI A(H7N9) cases with all LPAI A(H7N9) cases reported during the fifth epidemic. Results: A total of 27 cases of HPAI A(H7N9) virus were identified infection from five provinces, including Guangxi (44%), Guangdong (33%), Hunan (15%), Hebei (4%) and Shangxi (4%). The median age of cases of HPAI A(H7N9) virus infection was 60 years (range, 15 to 80) and most of them were male (59%) and lived in rural areas (78%). All 27 cases had live poultry related exposures within 10 days before their illness onset. In comparison with LPAI A(H7N9) case-patients, HPAI A(H7N9) case-patients were significantly more likely to live in rural areas (78% vs. 51%; p = 0.006), have exposure to the sick or dead poultry (56% vs. 19%; p = 0.000), and be hospitalized earlier (median 3 vs. 4 days; p = 0.007). No significant differences were observed in median age, sex, prevalence of underlying chronic medical conditions, median time from illness onset to first medical service seeking, starting antiviral treatment, and diagnosis. Although the median time from illness onset to death (9 vs. 13 days) was shorter and the overall case-fatality proportion (48% vs. 38%) was higher for HPAI A(H7N9) case-patients than for LPAI A(H7N9) case-patients, these differences were not statistically significant. Conclusions: Our findings indicate that HPAI A(H7N9) virus infection was associated with exposure to sick and dead poultry in rural areas when visited live poultry market or in the backyard. In the fifth epidemic in mainland China, HPAI A (H7N9) case-patients were hospitalized earlier than LPAI A(H7N9) case-patients. Although the difference was not statistically significant, the mortality of HPAI A (H7N9) case-patients was obviously higher than that of LPAI A(H7N9) case-patients, indicating a potential severity change of HPAI A(H7N9) virus infection. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Avian%20influenza%20A%20%28H7N9%29%20virus" title="Avian influenza A (H7N9) virus">Avian influenza A (H7N9) virus</a>, <a href="https://publications.waset.org/abstracts/search?q=highly%20pathogenic%20avian%20influenza%20%28HPAI%29" title=" highly pathogenic avian influenza (HPAI)"> highly pathogenic avian influenza (HPAI)</a>, <a href="https://publications.waset.org/abstracts/search?q=case-patients" title=" case-patients"> case-patients</a>, <a href="https://publications.waset.org/abstracts/search?q=poultry" title=" poultry"> poultry</a> </p> <a href="https://publications.waset.org/abstracts/85960/prevalent-features-of-human-infections-with-highly-pathogenic-avian-influenza-ah7n9-virus-china-2017" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/85960.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">166</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Safety and Efficacy of RM-001, Autologous HBG1/2 Promoter-Modified CD34+Hematopoietic Stem and Progenitor Cells, in Transfusion-Dependent β-Thalassemia</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rongrong%20Liu">Rongrong Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Li%20Wang"> Li Wang</a>, <a href="https://publications.waset.org/abstracts/search?q=Hui%20Xu"> Hui Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Jianpei%20Fang"> Jianpei Fang</a>, <a href="https://publications.waset.org/abstracts/search?q=Sixi%20Liu"> Sixi Liu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaolin%20Yin"> Xiaolin Yin</a>, <a href="https://publications.waset.org/abstracts/search?q=Junbin%20Liang"> Junbin Liang</a>, <a href="https://publications.waset.org/abstracts/search?q=Gaohui%20Yan"> Gaohui Yan</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaoyun%20Li"> Yaoyun Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yali%20Zhou"> Yali Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Xinyu%20Li"> Xinyu Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Yue%20Li"> Yue Li</a>, <a href="https://publications.waset.org/abstracts/search?q=Lei%20Shi"> Lei Shi</a>, <a href="https://publications.waset.org/abstracts/search?q=Yongrong%20Lai"> Yongrong Lai</a>, <a href="https://publications.waset.org/abstracts/search?q=Junjiu%20Huang"> Junjiu Huang</a>, <a href="https://publications.waset.org/abstracts/search?q=Xinhua%20Zhang"> Xinhua Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Beta-Thalassemia is caused by reduced (β+) or absent (β0) synthesis of the β-globin chains of hemoglobin. Transfusions and oral iron chelation therapy have improved the quality of life for patients with Transfusion-Dependent thalassemia (TDT). Recent advances in genome editing platforms of CRISPR-Cas9 have paved the way for induction of HbF by reactivating expression of γ-chain.Aims: We performed CRISPR-Cas9-mediated genome editing of hematopoietic stem cells to mutate HBG1/HBG2 promoter sequence, thereby representing a naturally occurring HPFH-liked mutation, producing RM-001. Here, we present an initial assessment of safety and efficacy of RM-001 in patients with TDT. Methods: Patients (6–35 y of age) with TDT receiving packed red blood cell (pRBC) transfusions of ≥100 mL/kg/y or ≥10 units/y in the previous 2 y were eligible. CD34+ cells were edited with CRISPR-Cas9 using a guide RNA specific for the binding site of BCL11A on the HBG1/2 promoter. Prior to RM-001 product infusion (day 0), patients received myeloablative conditioning with Busulfan from day-7 to day-4. Patients were monitored for AEs Hb expression.Results: Data cut as of 28 Feb 2024, 16 TDT patients have been treated with RM-001 and followed ≥3 months. 5 of these 16 patients had finished their 24 months follow up. Eleven patients have β0/β0 genotype and five patients have β0/β+ genotype. In addition to β-thalassemia, two patients had α- deletion with the genotype of --/αα. Efficacy:All patients received a single dose intravenous infusion of RM-001 cells. 5 of them had been followed 24 months or longer. All patients achieved transfusion-independent (TI, total Hb continued ≥ 9g/dL) (Figure1). Patients demonstrated sustained and clinically meaningful increases in HbF levels since 4 month post-RM-001 infusion (Figure.2). Total hemoglobin in all patients was stable at 10-12g/dL during the follow-up period. Safety:The adverse events observed after RM-001 infusion were consistent with those that are typical of Busulfan-based myeloablation. The allelic editing analysis at 6-month visit showed that the on-target allelic editing frequency in bone marrow cells was 73.44% (64.65% to 84.6%, n=13).Summary/Conclusion: This interim analysis, in which all the 19 patients age from 7.9 to 25yo met the success criteria for the trial with respect to transfusion independence, showed that autologous HBG1/2 promoter-modified CD34+ HSPCs gene therapy resulted in an adequate amount of HbF as early as 2 months after infusion led to near-normal hemoglobin levels, remained transfusion-free through the reported period without product related SAE. After RM-001 infusion, high levels of HbF proportion and on-target editing in bone marrow cells were maintained. Submitted on behalf of the RM-001 Investigators. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=thalassemian" title="thalassemian">thalassemian</a>, <a href="https://publications.waset.org/abstracts/search?q=genetherapy" title=" genetherapy"> genetherapy</a>, <a href="https://publications.waset.org/abstracts/search?q=CRISPR%2FCas9" title=" CRISPR/Cas9"> CRISPR/Cas9</a>, <a href="https://publications.waset.org/abstracts/search?q=HbF" title=" HbF"> HbF</a> </p> <a href="https://publications.waset.org/abstracts/184624/safety-and-efficacy-of-rm-001-autologous-hbg12-promoter-modified-cd34hematopoietic-stem-and-progenitor-cells-in-transfusion-dependent-v-thalassemia" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/184624.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">19</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 16th foundational anniversary</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Account <li><a href="https://waset.org/profile">My Account</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Explore <li><a href="https://waset.org/disciplines">Disciplines</a></li> <li><a href="https://waset.org/conferences">Conferences</a></li> <li><a href="https://waset.org/conference-programs">Conference Program</a></li> <li><a href="https://waset.org/committees">Committees</a></li> <li><a href="https://publications.waset.org">Publications</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Research <li><a href="https://publications.waset.org/abstracts">Abstracts</a></li> <li><a href="https://publications.waset.org">Periodicals</a></li> <li><a href="https://publications.waset.org/archive">Archive</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Open Science <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Philosophy.pdf">Open Science Philosophy</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Science-Award.pdf">Open Science Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Open-Society-Open-Science-and-Open-Innovation.pdf">Open Innovation</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Postdoctoral-Fellowship-Award.pdf">Postdoctoral Fellowship Award</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/Scholarly-Research-Review.pdf">Scholarly Research Review</a></li> </ul> </div> <div class="col-md-2"> <ul class="list-unstyled"> Support <li><a href="https://waset.org/page/support">Support</a></li> <li><a href="https://waset.org/profile/messages/create">Contact Us</a></li> <li><a href="https://waset.org/profile/messages/create">Report Abuse</a></li> </ul> </div> </div> </div> </div> </div> <div class="container text-center"> <hr style="margin-top:0;margin-bottom:.3rem;"> <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank" class="text-muted small">Creative Commons Attribution 4.0 International License</a> <div id="copy" class="mt-2">© 2024 World Academy of Science, Engineering and Technology</div> </div> </footer> <a href="javascript:" id="return-to-top"><i class="fas fa-arrow-up"></i></a> <div class="modal" id="modal-template"> <div class="modal-dialog"> <div class="modal-content"> <div class="row m-0 mt-1"> <div class="col-md-12"> <button type="button" class="close" data-dismiss="modal" aria-label="Close"><span aria-hidden="true">×</span></button> </div> </div> <div class="modal-body"></div> </div> </div> </div> <script src="https://cdn.waset.org/static/plugins/jquery-3.3.1.min.js"></script> <script src="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/js/bootstrap.bundle.min.js"></script> <script src="https://cdn.waset.org/static/js/site.js?v=150220211556"></script> <script> jQuery(document).ready(function() { /*jQuery.get("https://publications.waset.org/xhr/user-menu", function (response) { jQuery('#mainNavMenu').append(response); });*/ jQuery.get({ url: "https://publications.waset.org/xhr/user-menu", cache: false }).then(function(response){ jQuery('#mainNavMenu').append(response); }); }); </script> </body> </html>