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title="IL16 – Welsh" lang="cy" hreflang="cy" data-title="IL16" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/Interleucina_16" title="Interleucina 16 – Galician" lang="gl" hreflang="gl" data-title="Interleucina 16" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Interleuchina_16" title="Interleuchina 16 – Italian" lang="it" hreflang="it" data-title="Interleuchina 16" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Interleukina_16" title="Interleukina 16 – Polish" lang="pl" hreflang="pl" data-title="Interleukina 16" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Interleucina_16" title="Interleucina 16 – Portuguese" lang="pt" hreflang="pt" data-title="Interleucina 16" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%98%D0%BD%D1%82%D0%B5%D1%80%D0%BB%D0%B5%D1%83%D0%BA%D0%B8%D0%BD_16" title="Интерлеукин 16 – Serbian" lang="sr" hreflang="sr" data-title="Интерлеукин 16" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Protein-coding gene in the species Homo sapiens</div> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">IL16</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Protein_IL16_PDB_1i16.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9d/Protein_IL16_PDB_1i16.png/250px-Protein_IL16_PDB_1i16.png" decoding="async" width="250" height="283" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/9/9d/Protein_IL16_PDB_1i16.png 1.5x" data-file-width="301" data-file-height="341" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=O54824%20or%20Q14005%20or%20H0YLH9">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:O54824,Q14005,H0YLH9">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1I16">1I16</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1X6D">1X6D</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/5FB8">5FB8</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/5980">IL16</a></span>, LCF, NPRprIL-16, IL-16, interleukin 16</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/603035">603035</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:1270855">1270855</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=18157">18157</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=IL16">IL16</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000172349">IL16 - orthologs</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_15.svg" class="mw-file-description" title="Chromosome 15 (human)"><img alt="Chromosome 15 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/300px-Ideogram_human_chromosome_15.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/450px-Ideogram_human_chromosome_15.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/07/Ideogram_human_chromosome_15.svg/600px-Ideogram_human_chromosome_15.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_15_(human)" class="mw-redirect" title="Chromosome 15 (human)">Chromosome 15 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_15_ideogram.svg" class="mw-file-description" title="Chromosome 15 (human)"><img alt="Chromosome 15 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/300px-Human_chromosome_15_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/450px-Human_chromosome_15_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5c/Human_chromosome_15_ideogram.svg/600px-Human_chromosome_15_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 228.87950031015px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IL16"><img alt="Genomic location for IL16" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 234.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IL16"><img alt="Genomic location for IL16" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">15q25.1</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">81,159,575 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">81,314,058 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/260px-Ideogram_house_mouse_chromosome_7.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/390px-Ideogram_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/e/e4/Ideogram_house_mouse_chromosome_7.svg/520px-Ideogram_house_mouse_chromosome_7.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 7 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_7.svg" class="mw-file-description" title="Chromosome 7 (mouse)"><img alt="Chromosome 7 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/300px-Ideogram_of_house_mouse_chromosome_7.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/450px-Ideogram_of_house_mouse_chromosome_7.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2c/Ideogram_of_house_mouse_chromosome_7.svg/600px-Ideogram_of_house_mouse_chromosome_7.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 163.14950211275px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for IL16"><img alt="Genomic location for IL16" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 169.1px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for IL16"><img alt="Genomic location for IL16" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">7 D3|7 47.43 cM</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">83,292,033 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">83,394,934 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000172349">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">bone marrow cells</li><br /><li style="line-height: 137%;">appendix</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">monocyte</li><br /><li style="line-height: 137%;">lymph node</li><br /><li style="line-height: 137%;">cerebellar hemisphere</li><br /><li style="line-height: 137%;">right hemisphere of cerebellum</li><br /><li style="line-height: 137%;">tendon of biceps brachii</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000001741">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">pharynx</li><br /><li style="line-height: 137%;">granulocyte</li><br /><li style="line-height: 137%;">thymus</li><br /><li style="line-height: 137%;">spleen</li><br /><li style="line-height: 137%;">blood</li><br /><li style="line-height: 137%;">tibiofemoral joint</li><br /><li style="line-height: 137%;">mesenteric lymph nodes</li><br /><li style="line-height: 137%;">sciatic nerve</li><br /><li style="line-height: 137%;">cerebellar cortex</li><br /><li style="line-height: 137%;">dentate gyrus of hippocampal formation granule cell</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000172349">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_IL16_209827_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/PBB_GE_IL16_209827_s_at_fs.png/250px-PBB_GE_IL16_209827_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/6/65/PBB_GE_IL16_209827_s_at_fs.png/375px-PBB_GE_IL16_209827_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/6/65/PBB_GE_IL16_209827_s_at_fs.png/500px-PBB_GE_IL16_209827_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_IL16_209828_s_at_fs.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/PBB_GE_IL16_209828_s_at_fs.png/250px-PBB_GE_IL16_209828_s_at_fs.png" decoding="async" width="250" height="181" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/3/33/PBB_GE_IL16_209828_s_at_fs.png/375px-PBB_GE_IL16_209828_s_at_fs.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/3/33/PBB_GE_IL16_209828_s_at_fs.png/500px-PBB_GE_IL16_209828_s_at_fs.png 2x" data-file-width="732" data-file-height="530" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/3603/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005125">cytokine activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042609">CD4 receptor binding</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005622">intracellular anatomical structure</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005576">extracellular region</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005615">extracellular space</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016607">nuclear speck</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050930">induction of positive chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006935">chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016032">viral process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030595">leukocyte chemotaxis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006955">immune response</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051924">regulation of calcium ion transport</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010469">regulation of signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019221">cytokine-mediated signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=3603&rn=1">3603</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=16170&rn=1">16170</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000172349;db=core">ENSG00000172349</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000001741;db=core">ENSMUSG00000001741</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/Q14005">Q14005</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/O54824">O54824</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001172128">NM_001172128</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004513">NM_004513</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_172217">NM_172217</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001352684">NM_001352684</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001352685">NM_001352685</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001352686">NM_001352686</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010551">NM_010551</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001360087">NM_001360087</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001360088">NM_001360088</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001360089">NM_001360089</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001165599">NP_001165599</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004504">NP_004504</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_757366">NP_757366</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001339613">NP_001339613</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001339614">NP_001339614</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001339615">NP_001339615</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_034681">NP_034681</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001347016">NP_001347016</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001347017">NP_001347017</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001347018">NP_001347018</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr15:81159575-81314058">Chr 15: 81.16 – 81.31 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr7:83292033-83394934">Chr 7: 83.29 – 83.39 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14907199" class="extiw" title="d:Q14907199">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14907200" class="extiw" title="d:Q14907200">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Interleukin 16</b> is a <a href="/wiki/Inflammation" title="Inflammation">pro-inflammatory</a> pleiotropic <a href="/wiki/Cytokine" title="Cytokine">cytokine</a>. Its precursor, pro-interleukin-16 is a <a href="/wiki/Protein" title="Protein">protein</a> that in humans is encoded by the <i>IL16</i> <a href="/wiki/Gene" title="Gene">gene</a>.<sup id="cite_ref-pmid91442272_5-0" class="reference"><a href="#cite_note-pmid91442272-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-entrez3_6-0" class="reference"><a href="#cite_note-entrez3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> This gene was discovered in 1982 at <a href="/wiki/Boston_University" title="Boston University">Boston University</a> by Dr. David Center and Dr. William Cruikshank.<sup id="cite_ref-Cruikshank_19823_7-0" class="reference"><a href="#cite_note-Cruikshank_19823-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_16&action=edit&section=1" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The cytokine encoded by this gene is a pleiotropic cytokine that functions as a chemoattractant, a modulator of <a href="/wiki/T_cell" title="T cell">T cell</a> activation, and an inhibitor of <a href="/wiki/HIV" title="HIV">HIV</a> replication. The signaling process of this cytokine is mediated by <a href="/wiki/CD4" title="CD4">CD4</a>. The product of this gene undergoes <a href="/wiki/Proteolysis" title="Proteolysis">proteolytic</a> processing, which is found to yield two functional proteins. The cytokine function is exclusively attributed to the secreted <a href="/wiki/C-terminus" title="C-terminus">C-terminal</a> <a href="/wiki/Peptide" title="Peptide">peptide</a>, while the <a href="/wiki/N-terminus" title="N-terminus">N-terminal</a> product may play a role in <a href="/wiki/Cell_cycle" title="Cell cycle">cell cycle</a> control. <a href="/wiki/Caspase_3" title="Caspase 3">Caspase 3</a> is reported to be involved in the proteolytic processing of this protein. Two <a href="/wiki/Alternative_splicing" title="Alternative splicing">alternatively spliced transcript</a> variants encoding distinct <a href="/wiki/Protein_isoform" title="Protein isoform">isoforms</a> have been reported.<sup id="cite_ref-entrez3_6-1" class="reference"><a href="#cite_note-entrez3-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Interleukin 16 (IL-16) is released by a variety of cells (including <a href="/wiki/Lymphocytes" class="mw-redirect" title="Lymphocytes">lymphocytes</a> and some <a href="/wiki/Epithelial_cells" class="mw-redirect" title="Epithelial cells">epithelial cells</a>) that has been characterized as a <a href="/wiki/Chemoattractant" class="mw-redirect" title="Chemoattractant">chemoattractant</a> for certain immune cells expressing the cell surface molecule <a href="/wiki/CD4" title="CD4">CD4</a>. IL-16 was originally described as a factor that could attract activated <a href="/wiki/T_cells" class="mw-redirect" title="T cells">T cells</a> in humans, it was previously called lymphocyte chemoattractant factor (LCF).<sup id="cite_ref-Cruikshank_19823_7-1" class="reference"><a href="#cite_note-Cruikshank_19823-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Since then, this interleukin has been shown to recruit and activate many other cells expressing the CD4 molecule, including <a href="/wiki/Monocytes" class="mw-redirect" title="Monocytes">monocytes</a>, <a href="/wiki/Eosinophils" class="mw-redirect" title="Eosinophils">eosinophils</a>, and <a href="/wiki/Dendritic_cells" class="mw-redirect" title="Dendritic cells">dendritic cells</a>.<sup id="cite_ref-pmid108578462_8-0" class="reference"><a href="#cite_note-pmid108578462-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>The structure of IL-16 was determined following its <a href="/wiki/Gene_cloning" class="mw-redirect" title="Gene cloning">cloning</a> in 1994.<sup id="cite_ref-pmid79109672_9-0" class="reference"><a href="#cite_note-pmid79109672-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> This cytokine is produced as a precursor peptide (pro-IL-16) that requires processing by an <a href="/wiki/Enzyme" title="Enzyme">enzyme</a> called <a href="/wiki/Caspase" title="Caspase">caspase</a>-3 to become active. CD4 is the <a href="/wiki/Cell_signaling" title="Cell signaling">cell signaling</a> <a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">receptor</a> for mature IL-16. </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_16&action=edit&section=2" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Interleukin 16 has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <ul><li><a href="/wiki/GRIN2A" title="GRIN2A">GRIN2A</a>,<sup id="cite_ref-pmid10479680_10-0" class="reference"><a href="#cite_note-pmid10479680-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GRIN2D" title="GRIN2D">GRIN2D</a>,<sup id="cite_ref-pmid10479680_10-1" class="reference"><a href="#cite_note-pmid10479680-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/KCNJ10" title="KCNJ10">KCNJ10</a>,<sup id="cite_ref-pmid10479680_10-2" class="reference"><a href="#cite_note-pmid10479680-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/KCNJ15" title="KCNJ15">KCNJ15</a>,<sup id="cite_ref-pmid10479680_10-3" class="reference"><a href="#cite_note-pmid10479680-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Kir2.1" title="Kir2.1">Kir2.1</a>,<sup id="cite_ref-pmid10479680_10-4" class="reference"><a href="#cite_note-pmid10479680-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PPP1R12A" title="PPP1R12A">PPP1R12A</a>,<sup id="cite_ref-pmid12923170_11-0" class="reference"><a href="#cite_note-pmid12923170-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/PPP1R12B" title="PPP1R12B">PPP1R12B</a>.<sup id="cite_ref-pmid12923170_11-1" class="reference"><a href="#cite_note-pmid12923170-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup></li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_16&action=edit&section=3" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000172349">GRCh38: Ensembl release 89: ENSG00000172349</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000001741">GRCm38: Ensembl release 89: ENSMUSG00000001741</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome 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no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=3603">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D16170&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-pmid91442272-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid91442272_5-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBaierBannertWernerLang1997" class="citation journal cs1">Baier M, Bannert N, Werner A, Lang K, Kurth R (May 1997). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24668">"Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>94</b> (10): <span class="nowrap">5273–</span>5277. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1997PNAS...94.5273B">1997PNAS...94.5273B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.94.10.5273">10.1073/pnas.94.10.5273</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24668">24668</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9144227">9144227</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Molecular+cloning%2C+sequence%2C+expression%2C+and+processing+of+the+interleukin+16+precursor&rft.volume=94&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5273-%3C%2Fspan%3E5277&rft.date=1997-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC24668%23id-name%3DPMC&rft_id=info%3Apmid%2F9144227&rft_id=info%3Adoi%2F10.1073%2Fpnas.94.10.5273&rft_id=info%3Abibcode%2F1997PNAS...94.5273B&rft.aulast=Baier&rft.aufirst=M&rft.au=Bannert%2C+N&rft.au=Werner%2C+A&rft.au=Lang%2C+K&rft.au=Kurth%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC24668&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-entrez3-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-entrez3_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-entrez3_6-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3603">"Entrez Gene: IL16 interleukin 16 (lymphocyte chemoattractant factor)"</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Entrez+Gene%3A+IL16+interleukin+16+%28lymphocyte+chemoattractant+factor%29&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3FDb%3Dgene%26Cmd%3DShowDetailView%26TermToSearch%3D3603&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-Cruikshank_19823-7"><span 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=Modulation+of+lymphocyte+migration+by+human+lymphokines.+II.+Purification+of+a+lymphotactic+factor+%28LCF%29&rft.volume=128&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2569-%3C%2Fspan%3E2574&rft.date=1982-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A33890529%23id-name%3DS2CID&rft_id=info%3Apmid%2F7042841&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.128.6.2569&rft.aulast=Cruikshank&rft.aufirst=W&rft.au=Center%2C+DM&rft_id=http%3A%2F%2Fwww.jimmunol.org%2Fcgi%2Freprint%2F128%2F6%2F2569&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-pmid108578462-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid108578462_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCruikshankKornfeldCenter2000" class="citation journal cs1">Cruikshank WW, Kornfeld H, Center DM (June 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjlb.67.6.757">"Interleukin-16"</a>. <i>Journal of Leukocyte Biology</i>. <b>67</b> (6): <span class="nowrap">757–</span>766. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjlb.67.6.757">10.1002/jlb.67.6.757</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10857846">10857846</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Leukocyte+Biology&rft.atitle=Interleukin-16&rft.volume=67&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E757-%3C%2Fspan%3E766&rft.date=2000-06&rft_id=info%3Adoi%2F10.1002%2Fjlb.67.6.757&rft_id=info%3Apmid%2F10857846&rft.aulast=Cruikshank&rft.aufirst=WW&rft.au=Kornfeld%2C+H&rft.au=Center%2C+DM&rft_id=https%3A%2F%2Fdoi.org%2F10.1002%252Fjlb.67.6.757&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-pmid79109672-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid79109672_9-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCruikshankCenterNisarWu1994" class="citation journal cs1">Cruikshank WW, Center DM, Nisar N, Wu M, Natke B, Theodore AC, Kornfeld H (May 1994). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43941">"Molecular and functional analysis of a lymphocyte chemoattractant factor: association of biologic function with CD4 expression"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>91</b> (11): <span class="nowrap">5109–</span>5113. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1994PNAS...91.5109C">1994PNAS...91.5109C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.91.11.5109">10.1073/pnas.91.11.5109</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43941">43941</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7910967">7910967</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Molecular+and+functional+analysis+of+a+lymphocyte+chemoattractant+factor%3A+association+of+biologic+function+with+CD4+expression&rft.volume=91&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5109-%3C%2Fspan%3E5113&rft.date=1994-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC43941%23id-name%3DPMC&rft_id=info%3Apmid%2F7910967&rft_id=info%3Adoi%2F10.1073%2Fpnas.91.11.5109&rft_id=info%3Abibcode%2F1994PNAS...91.5109C&rft.aulast=Cruikshank&rft.aufirst=WW&rft.au=Center%2C+DM&rft.au=Nisar%2C+N&rft.au=Wu%2C+M&rft.au=Natke%2C+B&rft.au=Theodore%2C+AC&rft.au=Kornfeld%2C+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC43941&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-pmid10479680-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid10479680_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid10479680_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-pmid10479680_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-pmid10479680_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-pmid10479680_10-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKurschnerYuzaki1999" class="citation journal cs1">Kurschner C, Yuzaki M (September 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450">"Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein"</a>. <i>The Journal of Neuroscience</i>. <b>19</b> (18): <span class="nowrap">7770–</span>7780. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.19-18-07770.1999">10.1523/JNEUROSCI.19-18-07770.1999</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450">6782450</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10479680">10479680</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Neuronal+interleukin-16+%28NIL-16%29%3A+a+dual+function+PDZ+domain+protein&rft.volume=19&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E7770-%3C%2Fspan%3E7780&rft.date=1999-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782450%23id-name%3DPMC&rft_id=info%3Apmid%2F10479680&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.19-18-07770.1999&rft.aulast=Kurschner&rft.aufirst=C&rft.au=Yuzaki%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782450&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> <li id="cite_note-pmid12923170-11"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid12923170_11-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid12923170_11-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFBannertVollhardtAsomuddinovHaag2003" class="citation journal cs1">Bannert N, Vollhardt K, Asomuddinov B, Haag M, König H, Norley S, Kurth R (October 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M306669200">"PDZ Domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits"</a>. <i>The Journal of Biological Chemistry</i>. <b>278</b> (43): <span class="nowrap">42190–</span>42199. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M306669200">10.1074/jbc.M306669200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12923170">12923170</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=PDZ+Domain-mediated+interaction+of+interleukin-16+precursor+proteins+with+myosin+phosphatase+targeting+subunits&rft.volume=278&rft.issue=43&rft.pages=%3Cspan+class%3D%22nowrap%22%3E42190-%3C%2Fspan%3E42199&rft.date=2003-10&rft_id=info%3Adoi%2F10.1074%2Fjbc.M306669200&rft_id=info%3Apmid%2F12923170&rft.aulast=Bannert&rft.aufirst=N&rft.au=Vollhardt%2C+K&rft.au=Asomuddinov%2C+B&rft.au=Haag%2C+M&rft.au=K%C3%B6nig%2C+H&rft.au=Norley%2C+S&rft.au=Kurth%2C+R&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M306669200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_16&action=edit&section=4" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFWilsonCenterCruikshank2004" class="citation journal cs1">Wilson KC, Center DM, Cruikshank WW (June 2004). "The effect of interleukin-16 and its precursor on T lymphocyte activation and growth". <i>Growth Factors</i>. <b>22</b> (2): <span class="nowrap">97–</span>104. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1080%2F08977190410001704679">10.1080/08977190410001704679</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15253385">15253385</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:16860935">16860935</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Growth+Factors&rft.atitle=The+effect+of+interleukin-16+and+its+precursor+on+T+lymphocyte+activation+and+growth&rft.volume=22&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E97-%3C%2Fspan%3E104&rft.date=2004-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A16860935%23id-name%3DS2CID&rft_id=info%3Apmid%2F15253385&rft_id=info%3Adoi%2F10.1080%2F08977190410001704679&rft.aulast=Wilson&rft.aufirst=KC&rft.au=Center%2C+DM&rft.au=Cruikshank%2C+WW&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFCopeland2005" class="citation journal cs1">Copeland KF (December 2005). 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Mini+Reviews+in+Medicinal+Chemistry&rft.atitle=Modulation+of+HIV-1+transcription+by+cytokines+and+chemokines&rft.volume=5&rft.issue=12&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1093-%3C%2Fspan%3E1101&rft.date=2005-12&rft_id=info%3Adoi%2F10.2174%2F138955705774933383&rft_id=info%3Apmid%2F16375755&rft.aulast=Copeland&rft.aufirst=KF&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFRandCruikshankCenterWeller1991" class="citation journal cs1">Rand TH, Cruikshank WW, Center DM, Weller PF (June 1991). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2190841">"CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration"</a>. <i>The 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title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Immunology&rft.atitle=A+role+for+IL-16+in+the+cross-talk+between+dendritic+cells+and+T+cells&rft.volume=163&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3232-%3C%2Fspan%3E3238&rft.date=1999-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A36053665%23id-name%3DS2CID&rft_id=info%3Apmid%2F10477592&rft_id=info%3Adoi%2F10.4049%2Fjimmunol.163.6.3232&rft.aulast=Kaser&rft.aufirst=A&rft.au=Dunzendorfer%2C+S&rft.au=Offner%2C+FA&rft.au=Ryan%2C+T&rft.au=Schwabegger%2C+A&rft.au=Cruikshank%2C+WW&rft.au=Wiedermann%2C+CJ&rft.au=Tilg%2C+H&rft_id=https%3A%2F%2Fdoi.org%2F10.4049%252Fjimmunol.163.6.3232&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222"><cite id="CITEREFKurschnerYuzaki1999" class="citation journal cs1">Kurschner C, Yuzaki M (September 1999). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450">"Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein"</a>. <i>The Journal of Neuroscience</i>. <b>19</b> (18): <span class="nowrap">7770–</span>7780. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1523%2FJNEUROSCI.19-18-07770.1999">10.1523/JNEUROSCI.19-18-07770.1999</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782450">6782450</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10479680">10479680</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Neuroscience&rft.atitle=Neuronal+interleukin-16+%28NIL-16%29%3A+a+dual+function+PDZ+domain+protein&rft.volume=19&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E7770-%3C%2Fspan%3E7780&rft.date=1999-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782450%23id-name%3DPMC&rft_id=info%3Apmid%2F10479680&rft_id=info%3Adoi%2F10.1523%2FJNEUROSCI.19-18-07770.1999&rft.aulast=Kurschner&rft.aufirst=C&rft.au=Yuzaki%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6782450&rfr_id=info%3Asid%2Fen.wikipedia.org%3AInterleukin+16" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Interleukin_16&action=edit&section=5" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Overview of all the structural information available in the <a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a> for <a href="/wiki/UniProt" title="UniProt">UniProt</a>: <i><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/Q14005">Q14005</a></i> (Interleukin-16) at the <a href="/wiki/PDBe-KB" title="PDBe-KB">PDBe-KB</a>.</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output 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INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1i16_EBI.jpg/180px-PDB_1i16_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1i16_EBI.jpg/270px-PDB_1i16_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d1/PDB_1i16_EBI.jpg/360px-PDB_1i16_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1i16</b>: STRUCTURE OF INTERLEUKIN 16: IMPLICATIONS FOR FUNCTION, NMR, 20 STRUCTURES</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1x6d_EBI.jpg" class="mw-file-description" title="1x6d: Solution structures of the PDZ domain of human Interleukin-16"><img alt="1x6d: Solution structures of the PDZ domain of human Interleukin-16" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1x6d_EBI.jpg/180px-PDB_1x6d_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1x6d_EBI.jpg/270px-PDB_1x6d_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1c/PDB_1x6d_EBI.jpg/360px-PDB_1x6d_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1x6d</b>: Solution structures of the PDZ domain of human Interleukin-16</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Cell_signaling:_cytokines64" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" 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title="Cytokine">cytokines</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">By family</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Chemokine" title="Chemokine">Chemokine</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">CCL</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CCL1" title="CCL1">CCL1</a></li> <li><a href="/wiki/CCL2" title="CCL2">CCL2</a>/MCP1</li> <li><a href="/wiki/CCL3" title="CCL3">CCL3</a>/MIP1α</li> <li><a href="/wiki/CCL4" title="CCL4">CCL4</a>/MIP1β</li> <li><a href="/wiki/CCL5" title="CCL5">CCL5</a>/RANTES</li> <li><a href="/wiki/CCL6" title="CCL6">CCL6</a></li> <li><a href="/wiki/CCL7" title="CCL7">CCL7</a></li> <li><a href="/wiki/CCL8" title="CCL8">CCL8</a></li> <li><a href="/wiki/CCL9" title="CCL9">CCL9</a></li> <li><a href="/wiki/CCL11" title="CCL11">CCL11</a></li> <li><a href="/wiki/CCL12" title="CCL12">CCL12</a></li> <li><a href="/wiki/CCL13" title="CCL13">CCL13</a></li> <li><a href="/wiki/CCL14" title="CCL14">CCL14</a></li> <li><a href="/wiki/CCL15" title="CCL15">CCL15</a></li> <li><a href="/wiki/CCL16" title="CCL16">CCL16</a></li> <li><a href="/wiki/CCL17" title="CCL17">CCL17</a></li> <li><a href="/wiki/CCL18" title="CCL18">CCL18</a>/PARC/DCCK1/AMAC1/MIP4</li> <li><a href="/wiki/CCL19" title="CCL19">CCL19</a></li> <li><a href="/wiki/CCL20" title="CCL20">CCL20</a></li> <li><a href="/wiki/CCL21" title="CCL21">CCL21</a></li> <li><a href="/wiki/CCL22" title="CCL22">CCL22</a></li> <li><a href="/wiki/CCL23" title="CCL23">CCL23</a></li> <li><a href="/wiki/CCL24" title="CCL24">CCL24</a></li> <li><a href="/wiki/CCL25" title="CCL25">CCL25</a></li> <li><a href="/wiki/CCL26" title="CCL26">CCL26</a></li> <li><a href="/wiki/C-C_motif_chemokine_ligand_27" title="C-C motif chemokine ligand 27">CCL27</a></li> <li><a href="/wiki/CCL28" title="CCL28">CCL28</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CXCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CXCL1" title="CXCL1">CXCL1</a>/KC</li> <li><a href="/wiki/CXCL2" title="CXCL2">CXCL2</a></li> <li><a href="/wiki/CXCL3" title="CXCL3">CXCL3</a></li> <li><a href="/wiki/Platelet_factor_4" title="Platelet factor 4">CXCL4</a></li> <li><a href="/wiki/CXCL5" title="CXCL5">CXCL5</a></li> <li><a href="/wiki/CXCL6" title="CXCL6">CXCL6</a></li> <li><a href="/wiki/CXCL7" title="CXCL7">CXCL7</a></li> <li><a href="/wiki/Interleukin_8" title="Interleukin 8">CXCL8/IL8</a></li> <li><a href="/wiki/CXCL9" title="CXCL9">CXCL9</a></li> <li><a href="/wiki/CXCL10" title="CXCL10">CXCL10</a></li> <li><a href="/wiki/CXCL11" title="CXCL11">CXCL11</a></li> <li><a href="/wiki/SDF-1_(biology)" class="mw-redirect" title="SDF-1 (biology)">CXCL12</a></li> <li><a href="/wiki/CXCL13" title="CXCL13">CXCL13</a></li> <li><a href="/wiki/CXCL14" title="CXCL14">CXCL14</a></li> <li><a href="/wiki/CXCL15" title="CXCL15">CXCL15</a></li> <li><a href="/wiki/CXCL16" title="CXCL16">CXCL16</a></li> <li><a href="/wiki/CXCL17" title="CXCL17">CXCL17</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">CX3CL</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CX3CL1" title="CX3CL1">CX3CL1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">XCL</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/XCL1" title="XCL1">XCL1</a></li> <li><a href="/wiki/XCL2" title="XCL2">XCL2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tumor_necrosis_factors" class="mw-redirect" title="Tumor necrosis factors">TNF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li> <li><a href="/wiki/Lymphotoxin" title="Lymphotoxin">Lymphotoxin</a> <ul><li><a href="/wiki/Lymphotoxin_alpha" title="Lymphotoxin alpha">TNFB/LTA</a></li> <li><a href="/wiki/Lymphotoxin_beta" title="Lymphotoxin beta">TNFC/LTB</a></li></ul></li> <li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L">TNFSF4</a></li> <li><a href="/wiki/CD154" title="CD154">TNFSF5/CD40LG</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">TNFSF6</a></li> <li><a href="/wiki/CD70" title="CD70">TNFSF7</a></li> <li><a href="/wiki/CD153" title="CD153">TNFSF8</a></li> <li><a href="/wiki/4-1BB_ligand" class="mw-redirect" title="4-1BB ligand">TNFSF9</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">TNFSF10</a></li> <li><a href="/wiki/RANKL" title="RANKL">TNFSF11</a></li> <li><a href="/wiki/A_proliferation-inducing_ligand" class="mw-redirect" title="A proliferation-inducing ligand">TNFSF13</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">TNFSF13B</a></li> <li><a href="/wiki/EDA_(gene)" class="mw-redirect" title="EDA (gene)">EDA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interleukin" title="Interleukin">Interleukin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_I_cytokine_receptor" title="Type I cytokine receptor">Type I</a><br />(grouped by<br />receptor<br />subunit)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Common_gamma_chain" title="Common gamma chain">γ chain</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_2" title="Interleukin 2">IL2</a>/<a href="/wiki/Interleukin_15" title="Interleukin 15">IL15</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a>/<a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li> <li><a href="/wiki/Interleukin_7" title="Interleukin 7">IL7</a></li> <li><a href="/wiki/Interleukin_9" title="Interleukin 9">IL9</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">IL21</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/CSF2RB" title="CSF2RB">β chain</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_3" title="Interleukin 3">IL3</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor">GMCSF</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">IL6 like/<a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">gp130</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_11" title="Interleukin 11">IL11</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_30" title="Interleukin 30">IL30</a></li> <li><a href="/wiki/Interleukin_31" title="Interleukin 31">IL31</a> <ul><li>+non IL <a href="/wiki/Oncostatin_M" title="Oncostatin M">OSM</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">LIF</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor" title="Ciliary neurotrophic factor">CNTF</a></li> <li><a href="/wiki/Cardiotrophin_1" title="Cardiotrophin 1">CTF1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/w/index.php?title=IL12_family&action=edit&redlink=1" class="new" title="IL12 family (page does not exist)">IL12 family</a>/<a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">IL12RB1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_12" title="Interleukin 12">IL12</a></li> <li><a href="/wiki/Interleukin_23" title="Interleukin 23">IL23</a></li> <li><a href="/wiki/Interleukin_27" title="Interleukin 27">IL27</a></li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">IL35</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-taxilin" title="Alpha-taxilin">IL14</a></li> <li><a class="mw-selflink selflink">IL16</a></li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">IL32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">IL34</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Type_II_cytokine_receptor" title="Type II cytokine receptor">Type II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL10_family" class="mw-redirect" title="IL10 family">IL10 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a>/<a href="/wiki/Interleukin_22" title="Interleukin 22">IL22</a></li> <li><a href="/wiki/Interleukin_19" title="Interleukin 19">IL19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">IL20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">IL24</a></li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">IL26</a></li> <li><a href="/wiki/Interferon_type_III" title="Interferon type III">Interferon type III</a> <ul><li><a href="/wiki/Interleukin_28" title="Interleukin 28">IL28/IFNL2+3</a></li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">IL29/IFNL1</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon" title="Interferon">Interferon</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_I" title="Interferon type I">I</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_alpha_1" class="mw-redirect" title="Interferon alpha 1">IFNA1</a></li> <li><a href="/wiki/IFNA2" title="IFNA2">IFNA2</a></li> <li><a href="/wiki/IFNA4" title="IFNA4">IFNA4</a></li> <li><a href="/wiki/IFNA5" title="IFNA5">IFNA5</a></li> <li><a href="/wiki/IFNA6" title="IFNA6">IFNA6</a></li> <li><a href="/wiki/IFNA7" title="IFNA7">IFNA7</a></li> <li><a href="/wiki/IFNA8" title="IFNA8">IFNA8</a></li> <li><a href="/wiki/IFNA10" title="IFNA10">IFNA10</a></li> <li><a href="/wiki/IFNA13" title="IFNA13">IFNA13</a></li> <li><a href="/wiki/IFNA14" title="IFNA14">IFNA14</a></li> <li><a href="/wiki/IFNA16" title="IFNA16">IFNA16</a></li> <li><a href="/wiki/IFNA17" title="IFNA17">IFNA17</a></li> <li><a href="/wiki/IFNA21" title="IFNA21">IFNA21</a></li> <li><a href="/wiki/IFNB1" title="IFNB1">IFNB1</a></li> <li><a href="/wiki/IFNK" title="IFNK">IFNK</a></li> <li><a href="/wiki/IFNW1" title="IFNW1">IFNW1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Interferon_type_II" class="mw-redirect" title="Interferon type II">II</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNG</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Immunoglobulin_superfamily" title="Immunoglobulin superfamily">Ig superfamily</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_1_family" class="mw-redirect" title="Interleukin 1 family">IL1 family</a>: <a href="/wiki/IL1A" class="mw-redirect" title="IL1A">IL1A/IL1F1</a></li> <li><a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">IL1B/IL1F2</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">1Ra/IL1F3</a></li> <li><a href="/wiki/IL1F5" class="mw-redirect" title="IL1F5">IL1F5</a></li> <li><a href="/wiki/IL36A" title="IL36A">IL1F6</a></li> <li><a href="/wiki/IL1F7" class="mw-redirect" title="IL1F7">IL1F7</a></li> <li><a href="/wiki/IL36B" title="IL36B">IL1F8</a></li> <li><a href="/wiki/IL1F9" class="mw-redirect" title="IL1F9">IL1F9</a></li> <li><a href="/wiki/IL1F10" title="IL1F10">IL1F10</a></li> <li><a href="/wiki/Interleukin_33" title="Interleukin 33">33/IL1F11</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">18/IL1G</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/IL17_family" class="mw-redirect" title="IL17 family">IL17 family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_17" title="Interleukin 17">IL17</a>/<a href="/wiki/Interleukin_25" title="Interleukin 25">IL25</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">IL17A</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Hematopoietic" class="mw-redirect" title="Hematopoietic">Hematopoietic</a> <ul><li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">KITLG</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factor</a></li></ul></li> <li><a href="/wiki/Osteopontin" title="Osteopontin">SPP1</a></li> <li><a href="/wiki/Macrophage_migration_inhibitory_factor" title="Macrophage migration inhibitory factor">MIF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">By function/<br />cell</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Proinflammatory_cytokine" class="mw-redirect" title="Proinflammatory cytokine">proinflammatory cytokine</a></i> <ul><li><a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">IL1</a></li> <li><a href="/wiki/Tumor_necrosis_factor_alpha" class="mw-redirect" title="Tumor necrosis factor alpha">TNFA</a></li></ul></li></ul> <ul><li><a href="/wiki/Monokine" title="Monokine">Monokine</a></li> <li><a href="/wiki/Lymphokine" title="Lymphokine">Lymphokine</a> <ul><li><i>T<sub>h</sub>1</i> <ul><li><a href="/wiki/Interferon_gamma" title="Interferon gamma">IFNγ</a></li> <li><a href="/wiki/Tumor_necrosis_factor_beta" class="mw-redirect" title="Tumor necrosis factor beta">TNFβ</a></li></ul></li> <li><i>T<sub>h</sub>2</i> <ul><li><a href="/wiki/Interleukin_4" title="Interleukin 4">IL4</a></li> <li><a href="/wiki/Interleukin_5" title="Interleukin 5">IL5</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">IL6</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">IL10</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">IL13</a></li></ul></li></ul></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235"></div><div role="navigation" class="navbox" aria-labelledby="Interleukin_receptor_modulators601" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231"><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Interleukin_receptor_modulators" title="Template:Interleukin receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Interleukin_receptor_modulators" title="Template talk:Interleukin receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Interleukin_receptor_modulators" title="Special:EditPage/Template:Interleukin receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Interleukin_receptor_modulators601" style="font-size:114%;margin:0 4em"><a href="/wiki/Interleukin_receptor" title="Interleukin receptor">Interleukin receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-1_receptor" title="Interleukin-1 receptor">IL-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_1" class="mw-redirect" title="Interleukin 1">Interleukin 1</a> (<a href="/wiki/Interleukin_1_alpha" class="mw-redirect" title="Interleukin 1 alpha">α</a>, <a href="/wiki/Interleukin_1_beta" title="Interleukin 1 beta">β</a>)</li> <li><a href="/w/index.php?title=Mobenakin&action=edit&redlink=1" class="new" title="Mobenakin (page does not exist)">Mobenakin</a></li> <li><a href="/w/index.php?title=Pifonakin&action=edit&redlink=1" class="new" title="Pifonakin (page does not exist)">Pifonakin</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=AF-12198&action=edit&redlink=1" class="new" title="AF-12198 (page does not exist)">AF-12198</a></li> <li><a href="/wiki/Anakinra" title="Anakinra">Anakinra</a></li> <li><a href="/wiki/Interleukin_1_receptor_antagonist" class="mw-redirect" title="Interleukin 1 receptor antagonist">IL-1RA</a></li> <li><a href="/w/index.php?title=Isunakinra&action=edit&redlink=1" class="new" title="Isunakinra (page does not exist)">Isunakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Canakinumab" title="Canakinumab">Canakinumab</a></li> <li><a href="/wiki/Gevokizumab" title="Gevokizumab">Gevokizumab</a></li> <li><a href="/w/index.php?title=Lutikizumab&action=edit&redlink=1" class="new" title="Lutikizumab (page does not exist)">Lutikizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Rilonacept" title="Rilonacept">Rilonacept (IL-1 Trap)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-2_receptor" class="mw-redirect" title="Interleukin-2 receptor">IL-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Adargileukin_alfa&action=edit&redlink=1" class="new" title="Adargileukin alfa (page does not exist)">Adargileukin alfa</a></li> <li><a href="/wiki/Aldesleukin" class="mw-redirect" title="Aldesleukin">Aldesleukin</a></li> <li><a href="/w/index.php?title=Celmoleukin&action=edit&redlink=1" class="new" title="Celmoleukin (page does not exist)">Celmoleukin</a></li> <li><a href="/wiki/Denileukin_diftitox" title="Denileukin diftitox">Denileukin diftitox</a></li> <li><a href="/wiki/Interleukin_2" title="Interleukin 2">Interleukin 2</a></li> <li><a href="/w/index.php?title=Pegaldesleukin&action=edit&redlink=1" class="new" title="Pegaldesleukin (page does not exist)">Pegaldesleukin</a></li> <li><a href="/w/index.php?title=Teceleukin&action=edit&redlink=1" class="new" title="Teceleukin (page does not exist)">Teceleukin</a></li> <li><a href="/wiki/Tucotuzumab_celmoleukin" title="Tucotuzumab celmoleukin">Tucotuzumab celmoleukin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Basiliximab" title="Basiliximab">Basiliximab</a></li> <li><a href="/wiki/Daclizumab" title="Daclizumab">Daclizumab (dacliximab)</a></li> <li><a href="/wiki/Inolimomab" title="Inolimomab">Inolimomab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-3_receptor" title="Interleukin-3 receptor">IL-3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Daniplestim&action=edit&redlink=1" class="new" title="Daniplestim (page does not exist)">Daniplestim</a></li> <li><a href="/wiki/Interleukin_3" title="Interleukin 3">Interleukin 3</a></li> <li><a href="/w/index.php?title=Leridistim&action=edit&redlink=1" class="new" title="Leridistim (page does not exist)">Leridistim</a></li> <li><a href="/w/index.php?title=Milodistim&action=edit&redlink=1" class="new" title="Milodistim (page does not exist)">Milodistim</a></li> <li><a href="/w/index.php?title=Muplestim&action=edit&redlink=1" class="new" title="Muplestim (page does not exist)">Muplestim</a></li> <li><a href="/wiki/Promegapoietin" title="Promegapoietin">Promegapoietin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">IL-4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Pitrakinra" title="Pitrakinra">Pitrakinra</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dupilumab" title="Dupilumab">Dupilumab</a></li> <li><a href="/wiki/Pascolizumab" title="Pascolizumab">Pascolizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-5_receptor" title="Interleukin-5 receptor">IL-5</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_5" title="Interleukin 5">Interleukin 5</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=YM-90709&action=edit&redlink=1" class="new" title="YM-90709 (page does not exist)">YM-90709</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Benralizumab" title="Benralizumab">Benralizumab</a></li> <li><a href="/wiki/Mepolizumab" title="Mepolizumab">Mepolizumab</a></li> <li><a href="/wiki/Reslizumab" title="Reslizumab">Reslizumab</a></li></ul> <ul><li><i>Antisense oligonucleotides:</i> <a href="/w/index.php?title=TPI_ASM8&action=edit&redlink=1" class="new" title="TPI ASM8 (page does not exist)">TPI ASM8</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">IL-6</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Atexakin_alfa&action=edit&redlink=1" class="new" title="Atexakin alfa (page does not exist)">Atexakin alfa</a></li> <li><a href="/wiki/Interleukin_6" title="Interleukin 6">Interleukin 6</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=ARGX-109&action=edit&redlink=1" class="new" title="ARGX-109 (page does not exist)">ARGX-109</a></li> <li><a href="/wiki/Clazakizumab" title="Clazakizumab">Clazakizumab</a></li> <li><a href="/wiki/Elsilimomab" title="Elsilimomab">Elsilimomab</a></li> <li><a href="/w/index.php?title=MAb_1339&action=edit&redlink=1" class="new" title="MAb 1339 (page does not exist)">mAb 1339</a></li> <li><a href="/wiki/Olokizumab" title="Olokizumab">Olokizumab</a></li> <li><a href="/wiki/Sarilumab" title="Sarilumab">Sarilumab</a></li> <li><a href="/wiki/Siltuximab" title="Siltuximab">Siltuximab</a></li> <li><a href="/wiki/Sirukumab" title="Sirukumab">Sirukumab</a></li> <li><a href="/wiki/Tocilizumab" title="Tocilizumab">Tocilizumab</a></li> <li><a href="/wiki/Levilimab" title="Levilimab">Levilimab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">IL-7</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_7" title="Interleukin 7">Interleukin 7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-8_receptor" title="Interleukin-8 receptor">IL-8</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) <a href="/wiki/Template:Chemokine_receptor_modulators" title="Template:Chemokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_9_receptor" class="mw-redirect" title="Interleukin 9 receptor">IL-9</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_9" title="Interleukin 9">Interleukin 9</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Enokizumab&action=edit&redlink=1" class="new" title="Enokizumab (page does not exist)">Enokizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-10_receptor" title="Interleukin-10 receptor">IL-10</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ilodecakin&action=edit&redlink=1" class="new" title="Ilodecakin (page does not exist)">Ilodecakin</a></li> <li><a href="/wiki/Interleukin_10" title="Interleukin 10">Interleukin 10 (CSIF)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-11_receptor" title="Interleukin-11 receptor">IL-11</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_11" title="Interleukin 11">Interleukin 11 (AGIF)</a></li> <li><a href="/wiki/Oprelvekin" title="Oprelvekin">Oprelvekin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-12_receptor" title="Interleukin-12 receptor">IL-12</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Edodekin_alfa&action=edit&redlink=1" class="new" title="Edodekin alfa (page does not exist)">Edodekin alfa</a></li> <li><a href="/wiki/Interleukin_12" title="Interleukin 12">Interleukin 12</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-13_receptor" title="Interleukin-13 receptor">IL-13</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Binetrakin&action=edit&redlink=1" class="new" title="Binetrakin (page does not exist)">Binetrakin</a></li> <li><a href="/w/index.php?title=Cintredekin_besudotox&action=edit&redlink=1" class="new" title="Cintredekin besudotox (page does not exist)">Cintredekin besudotox</a></li> <li><a href="/wiki/Interleukin_4" title="Interleukin 4">Interleukin 4</a></li> <li><a href="/wiki/Interleukin_13" title="Interleukin 13">Interleukin 13</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Anrukinzumab" title="Anrukinzumab">Anrukinzumab</a></li> <li><a href="/wiki/Lebrikizumab" title="Lebrikizumab">Lebrikizumab</a></li> <li><a href="/wiki/Tralokinumab" title="Tralokinumab">Tralokinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-15_receptor" title="Interleukin-15 receptor">IL-15</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/ALT-803" class="mw-redirect" title="ALT-803">ALT-803</a></li> <li><a href="/wiki/Interleukin_15" title="Interleukin 15">Interleukin 15</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-17_receptor" title="Interleukin-17 receptor">IL-17</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_17" title="Interleukin 17">Interleukin 17</a> (<a href="/wiki/IL17A" class="mw-redirect" title="IL17A">A</a>, <a href="/w/index.php?title=IL17B&action=edit&redlink=1" class="new" title="IL17B (page does not exist)">B</a>, <a href="/w/index.php?title=IL17C&action=edit&redlink=1" class="new" title="IL17C (page does not exist)">C</a>, <a href="/w/index.php?title=IL17D&action=edit&redlink=1" class="new" title="IL17D (page does not exist)">D</a>, <a href="/wiki/IL17E" class="mw-redirect" title="IL17E">E (interleukin 25)</a>, <a href="/wiki/IL17F" class="mw-redirect" title="IL17F">F</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brodalumab" title="Brodalumab">Brodalumab</a></li> <li><a href="/wiki/Ixekizumab" title="Ixekizumab">Ixekizumab</a></li> <li><a href="/wiki/Perakizumab" title="Perakizumab">Perakizumab</a></li> <li><a href="/w/index.php?title=Remtolumab&action=edit&redlink=1" class="new" title="Remtolumab (page does not exist)">Remtolumab</a></li> <li><a href="/wiki/Secukinumab" title="Secukinumab">Secukinumab</a></li> <li><a href="/w/index.php?title=Vunakizumab&action=edit&redlink=1" class="new" title="Vunakizumab (page does not exist)">Vunakizumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-18_receptor" title="Interleukin-18 receptor">IL-18</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Iboctadekin&action=edit&redlink=1" class="new" title="Iboctadekin (page does not exist)">Iboctadekin</a></li> <li><a href="/wiki/Interleukin_18" title="Interleukin 18">Interleukin 18</a></li> <li><a href="/wiki/Interleukin_37" title="Interleukin 37">Interleukin 37</a></li> <li><a href="/w/index.php?title=Tadekinig&action=edit&redlink=1" class="new" title="Tadekinig (page does not exist)">Tadekinig</a></li></ul> <ul><li><i>Binding proteins:</i> <a href="/wiki/IL18BP" title="IL18BP">IL18BP</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-20_receptor" title="Interleukin-20 receptor">IL-20</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_19" title="Interleukin 19">Interleukin 19</a></li> <li><a href="/wiki/Interleukin_20" title="Interleukin 20">Interleukin 20</a></li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fletikumab" title="Fletikumab">Fletikumab</a> (against IL-20)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-21_receptor" title="Interleukin-21 receptor">IL-21</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Denenicokin&action=edit&redlink=1" class="new" title="Denenicokin (page does not exist)">Denenicokin</a></li> <li><a href="/wiki/Interleukin_21" title="Interleukin 21">Interleukin 21</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=NNC0114-0005&action=edit&redlink=1" class="new" title="NNC0114-0005 (page does not exist)">NNC0114-0005</a></li> <li><a href="/w/index.php?title=NNC0114-0006&action=edit&redlink=1" class="new" title="NNC0114-0006 (page does not exist)">NNC0114-0006</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-22_receptor" title="Interleukin-22 receptor">IL-22</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_22" title="Interleukin 22">Interleukin 22</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Fezakinumab" title="Fezakinumab">Fezakinumab</a> (against IL-22)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-23_receptor" title="Interleukin-23 receptor">IL-23</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_23" title="Interleukin 23">Interleukin 23 (SGRF)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Brazikumab" title="Brazikumab">Brazikumab</a></li> <li><a href="/wiki/Briakinumab" title="Briakinumab">Briakinumab</a></li> <li><a href="/wiki/Guselkumab" title="Guselkumab">Guselkumab</a></li> <li><a href="/wiki/Risankizumab" title="Risankizumab">Risankizumab</a></li> <li><a href="/wiki/Tildrakizumab" title="Tildrakizumab">Tildrakizumab</a></li> <li><a href="/wiki/Ustekinumab" title="Ustekinumab">Ustekinumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-27_receptor" title="Interleukin-27 receptor">IL-27</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_27" title="Interleukin 27">Interleukin 27 (interleukin 30)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-28_receptor" title="Interleukin-28 receptor">IL-28</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Interferon_%CE%BB4&action=edit&redlink=1" class="new" title="Interferon λ4 (page does not exist)">Interferon λ4 (IFN-λ4)</a></li> <li><a href="/wiki/Interleukin_28" title="Interleukin 28">Interleukin 28</a> (<a href="/w/index.php?title=Interleukin_28A&action=edit&redlink=1" class="new" title="Interleukin 28A (page does not exist)">A (IFN-λ2)</a>, <a href="/wiki/Interleukin_28B" class="mw-redirect" title="Interleukin 28B">B (IFN-λ3)</a>)</li> <li><a href="/wiki/Interleukin_29" title="Interleukin 29">Interleukin-29 (IFN-λ1)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin-31_receptor" title="Interleukin-31 receptor">IL-31</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_31" title="Interleukin 31">Interleukin 31</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_1" class="mw-redirect" title="Interleukin 1 receptor-like 1">IL1RL1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_33" title="Interleukin 33">Interleukin 33</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Interleukin_1_receptor-like_2" class="mw-redirect" title="Interleukin 1 receptor-like 2">IL1RL2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Interleukin_36" title="Interleukin 36">Interleukin 36</a> (<a href="/wiki/IL36A" title="IL36A">α</a>, <a href="/wiki/IL36B" title="IL36B">β</a>, <a href="/wiki/IL36G" title="IL36G">γ</a>)</li> <li><a href="/wiki/Interleukin_38" class="mw-redirect" title="Interleukin 38">Interleukin 38</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Interleukin_36_receptor_antagonist" title="Interleukin 36 receptor antagonist">IL-36RA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Interleukin_14" class="mw-redirect" title="Interleukin 14">Interleukin 14 (taxilin alpha, HMW-BCGF)</a></li> <li><a class="mw-selflink selflink">Interleukin 16</a> (signals through <a href="/wiki/CD4" title="CD4">CD4</a>)</li> <li><a href="/wiki/Interleukin_24" title="Interleukin 24">Interleukin 24</a> (signals through <a href="/wiki/IL22RA1" title="IL22RA1">IL-22Rα1</a>/<a href="/wiki/Interleukin_20_receptor,_beta_subunit" title="Interleukin 20 receptor, beta subunit">IL-20Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_26" title="Interleukin 26">Interleukin 26</a> (signals through <a href="/wiki/Interleukin_20_receptor,_alpha_subunit" title="Interleukin 20 receptor, alpha subunit">IL-20Rα</a>/<a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">IL-10Rβ</a> heterodimer)</li> <li><a href="/wiki/Interleukin_32" title="Interleukin 32">Interleukin 32</a></li> <li><a href="/wiki/Interleukin_34" title="Interleukin 34">Interleukin 34</a> (signals through <a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">M-CSFR/CSF1R</a>)</li> <li><a href="/wiki/Interleukin_35" title="Interleukin 35">Interleukin 35</a></li></ul> <ul><li><i>Unsorted:</i> <a href="/wiki/Efavaleukin_alfa" title="Efavaleukin alfa">Efavaleukin alfa</a></li> <li><a href="/w/index.php?title=Efineptakin_alfa&action=edit&redlink=1" class="new" title="Efineptakin alfa (page does not exist)">Efineptakin alfa</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <p><i>This article incorporates text from the <a href="/wiki/United_States_National_Library_of_Medicine" title="United States National Library of Medicine">United States National Library of Medicine</a>, which is in the <a href="/wiki/Public_domain" title="Public domain">public domain</a>.</i> </p>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?useformat=desktop&type=1x1&usesul3=0" alt="" width="1" height="1" style="border: none; position: absolute;"></noscript> <div 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