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KEGG DRUG: Fentanyl
<!doctype html> <html><head> <title>KEGG DRUG: Fentanyl</title> <link type="text/css" rel="stylesheet" href="/css/gn2.css?1743962473"> <link type="text/css" rel="stylesheet" href="/css/bget.css?1743962473"> <meta name="viewport" content="width=device-width, initial-scale=1.0"> <link type="text/css" rel="stylesheet" href="/css/bgetm.css?1743962473" media="only screen and (max-width: 768px)"> <style>.kcfd{display:none;}</style> <script> <!-- var getElementsByClassName = document.getElementsByClassName ? function (cl){ return document.getElementsByClassName(cl); } : function (cl){ var elms = []; var objs = document.getElementsByTagName('*'); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(obj.className == cl){ elms.push(obj); } } return elms; }; function toggleField(clk,cl,show,hide){ var objs = getElementsByClassName(cl); for(var i=0;i<objs.length;i++){ var obj = objs[i]; if(!obj.style.display||obj.style.display == 'none'){ obj.style.display = 'block'; clk.innerHTML = ' « '+hide; } 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form.setAttribute(key,params[key]); } else{ var obj = document.createElement('input'); obj.setAttribute('type','hidden'); obj.setAttribute('name',key); obj.setAttribute('value',params[key]); form.appendChild(obj); } } form.submit(); } window.onload=function(){window.focus();init();}; //---> </script> </head> <body> <div> <table border=0 cellpadding=0 cellspacing=0><tr><td> <table border=0 cellpadding=0 cellspacing=0 width="668"><tr><td width=70><a href="/kegg/drug"><img align="middle" alt="KEGG" border=0 src="/Fig/bget/kegg5.gif"></a></td><td> </td><td><a name="drug:D00320"></a><font class="title5">DRUG: Fentanyl</font></td><td class="tar vbot"><button class="btn" onclick="javascript:void(window.open('/kegg/document/help_bget_drug.html','KEGG_Help','toolbar=no,location=no,directories=no,width=720,height=640,resizable=yes,scrollbars=yes'));return false;">Help</button></td></tr></table><form method="post" action="/entry/" enctype="application/x-www-form-urlencoded" id="form1" name="form1"></form><table class="w1" width="650"> <tr> <td class="fr5 w1"> <table width="650" class="w2"> <tr><th class="th50 deft tal vmid"><span class="nowrap">Entry</span></th> <td class="td50 defd"><table class="w1" width="100%"><tr><td class="tal pd0"><code><span class="nowrap">D00320 Drug <br> </span></code></td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Name</span></th> <td class="td51 defd"><div class="cel">Fentanyl (JAN/USP/INN);<br>Duragesic (TN);<br>Subsys (TN)</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Product</span></th> <td class="td50 defd"></td></tr> <tr><th class="th51 rept tal vtop"><span class="nowrap"> Generic</span></th> <td class="td51 repd"><div class="cel"><a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0ff70df0-2cda-d96c-42a8-3bf180310498">FENTANYL (Apotex Corp.)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=0ff70df0-2cda-d96c-42a8-3bf180310499">FENTANYL (Apotex Corp.)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=529836fc-527c-45d8-a318-ab5513c053fe">FENTANYL (Bryant Ranch Prepack)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=578def77-4959-4392-83a8-0abfcbf1d023">FENTANYL (Bryant Ranch Prepack)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=7c51f184-c2a0-4867-b8fb-d58910ee1966">FENTANYL (Bryant Ranch Prepack)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=bf02ffd0-cc5d-446b-b648-378f6885052f">FENTANYL (INGENUS PHARMACEUTICALS)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2a2238e9-4b5d-c56d-8663-dd354ff9ae0c">FENTANYL (Mylan Pharmaceuticals)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3bbc19e3-5bf1-495a-b698-3d77f83236e9">FENTANYL (Quality Care Products)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=242759ef-cb6d-4e3e-9f8d-5e31efa1f289">FENTANYL SYSTEM (ALVOGEN)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ff9536e1-a4e8-4eb3-901c-ba9b86256672">FENTANYL SYSTEM (Lake Erie Medical DBA Quality Care Products LLC)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=18d3e9ef-eb61-44d2-b58c-207015122e13">FENTANYL SYSTEM (Quality Care Products)</a>, <a href="https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=e15a7e9b-8025-49dd-9a6d-bafcccf1959f">FENTANYL TRANSDERMAL (SpecGx LLC)</a></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Formula</span></th> <td class="td50 defd"><div class="cel">C22H28N2O<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Exact mass</span></th> <td class="td51 defd"><div class="cel">336.2202<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Mol weight</span></th> <td class="td50 defd"><div class="cel">336.47<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure</span></th> <td class="td51 defd"><a href="/Fig/drug/D00320.gif"><img name="img0" src="/Fig/drug/D00320.gif" style="max-width:600px" border=0></a><br> <button class="btn" onclick="location.href='/entry/-f+m+D00320';return false;">Mol file</button><button class="btn" onclick="location.href='/entry/-f+k+D00320';return false;">KCF file</button><button class="btn" onclick="location.href='https://www.genome.jp/tools-bin/strsearch_view?ENTRY=D00320&PROGRAM=simcomp&DATABASE=drug';return false;">DB search</button></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">Simcomp</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='/kegg-bin/simcomp_list?id=D00320';return false;">Neighbor</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Class</span></th> <td class="td51 defd"><div class="cel"><span class="nowrap">Neuropsychiatric agent<br> <a href="/entry/DG02030">DG02030</a> Anesthetics<br> <a href="/entry/DG02027">DG02027</a> General anesthetics<br> <a href="/entry/DG02026">DG02026</a> Opioid anesthetics<br> <a href="/entry/DG01564">DG01564</a> Opioid receptor agonist<br> <a href="/entry/DG01563">DG01563</a> mu-Opioid receptor agonist<br> Analgesic<br> <a href="/entry/DG01984">DG01984</a> Opioid analgesics<br> Metabolizing enzyme substrate<br> <a href="/entry/DG01633">DG01633</a> CYP3A/CYP3A4 substrate<br> <a href="/entry/DG02913">DG02913</a> CYP3A4 substrate<br> </span></div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Remark</span></th> <td class="td50 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Therapeutic category: </span></td><td><a href="/brite/br08301+D00320">8219</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ATC code: </span></td><td><a href="/brite/br08303+D00320">N01AH01 N02AB03</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Chemical structure group: </span></td><td><a href="/entry/DG00791">DG00791</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">Product (DG00791): </span></td><td>D00320<<a href="/entry/dr_ja:D00320">JP</a>/US> D01399<<a href="/entry/dr_ja:D01399">JP</a>/<a href="/entry/D01399">US</a>> </td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Efficacy</span></th> <td class="td51 defd"><div class="cel">Analgesic (narcotic), Opioid receptor agonist</div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Comment</span></th> <td class="td50 defd"><div class="cel">synthetic-opioid<br> Phenylpiperidine derivative<br> </div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Target</span></th> <td class="td51 defd"><div class="cel">OPRM1 [HSA:<a href="/entry/hsa:4988">4988</a>] [KO:<a href="/entry/K04215">K04215</a>]</div></td></tr> <tr><th class="th50 rept tal vtop"><span class="nowrap"> Pathway</span></th> <td class="td50 repd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/hsa04080+4988">hsa04080</a> </span></td><td>Neuroactive ligand-receptor interaction</td></tr></table></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Metabolism</span></th> <td class="td51 defd"><div class="cel">Enzyme: CYP3A4 [HSA:<a href="/entry/hsa:1576">1576</a>]<br> </div></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Interaction</span></th> <td class="td50 defd"><div class="cel"><button class="btn" onclick="location.href='/kegg-bin/ddi_list?drug=D00320';return false;">DDI search</button></div></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Structure map</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07039+D00320">map07039</a> </span></td><td>Opioid analgesics</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap"><a href="/pathway/map07224+D00320">map07224</a> </span></td><td>Opioid receptor agonists/antagonists</td></tr></table></td></tr> <tr><th class="th50 deft tal vtop"><span class="nowrap">Brite</span></th> <td class="td50 defd"><div class="cel"><span class="nowrap">Anatomical Therapeutic Chemical (ATC) classification [BR:<a href="/brite/br08303+D00320">br08303</a>]<br> N NERVOUS SYSTEM<br> N01 ANESTHETICS<br> N01A ANESTHETICS, GENERAL<br> N01AH Opioid anesthetics<br> N01AH01 Fentanyl<br> D00320 Fentanyl (JAN/USP/INN) <JP/US><br> N02 ANALGESICS<br> N02A OPIOIDS<br> N02AB Phenylpiperidine derivatives<br> N02AB03 Fentanyl<br> D00320 Fentanyl (JAN/USP/INN) <JP/US><br> USP drug classification [BR:<a href="/brite/br08302+D00320">br08302</a>]<br> Analgesics<br> Opioid Analgesics, Long-acting<br> Fentanyl<br> D00320 Fentanyl (JAN/USP/INN)<br> Opioid Analgesics, Short-acting<br> Fentanyl<br> D00320 Fentanyl (JAN/USP/INN)<br> Therapeutic category of drugs in Japan [BR:<a href="/brite/br08301+D00320">br08301</a>]<br> 8 Narcotics<br> 82 Non-alkaloidal narcotics<br> 821 Synthetic narcotics<br> 8219 Others<br> D00320 Fentanyl (JAN/USP/INN)<br> Drug groups [BR:<a href="/brite/br08330+D00320+DG02030">br08330</a>]<br> Neuropsychiatric agent<br> DG02030 Anesthetics<br> DG02027 General anesthetics<br> DG02026 Opioid anesthetics<br> DG00791 Fentanyl<br> D00320 Fentanyl<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG00791 Fentanyl<br> D00320 Fentanyl<br> Analgesic<br> DG01984 Opioid analgesics<br> DG00791 Fentanyl<br> D00320 Fentanyl<br> Metabolizing enzyme substrate<br> DG01633 CYP3A/CYP3A4 substrate<br> DG02913 CYP3A4 substrate<br> DG00791 Fentanyl<br> D00320 Fentanyl<br> Target-based classification of drugs [BR:<a href="/brite/br08310+D00320">br08310</a>]<br> G Protein-coupled receptors<br> Rhodopsin family<br> Opioid<br> OPRM1<br> D00320 Fentanyl (JAN/USP/INN) <JP/US><br> Drug metabolizing enzymes and transporters [<a href="/kegg/drug/br08309.html?id=D00320">br08309.html</a>]<br> Drug metabolizing enzymes<br> D00320<br> Narcotics and psychotropics in Japan [<a href="/kegg/drug/br08308.html?id=D00320">br08308.html</a>]<br> Narcotics by Cabinet Order Article 1 (163 substances)<br> D00320<br> Drug groups [BR:<a href="/brite/br08330+D00320+DG02030">br08330</a>]<br> Neuropsychiatric agent<br> DG02030 Anesthetics<br> DG02027 General anesthetics<br> DG02026 Opioid anesthetics<br> DG00791 Fentanyl<br> DG01564 Opioid receptor agonist<br> DG01563 mu-Opioid receptor agonist<br> DG00791 Fentanyl<br> Analgesic<br> DG01984 Opioid analgesics<br> DG00791 Fentanyl<br> Metabolizing enzyme substrate<br> DG01633 CYP3A/CYP3A4 substrate<br> DG02913 CYP3A4 substrate<br> DG00791 Fentanyl<br> </span></div><button class="btn" onclick="location.href='/kegg-bin/search_brite?option=-a&search_string=D00320';return false;">BRITE hierarchy</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">Other DBs</span></th> <td class="td51 defd"><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">CAS: </span></td><td>437-38-7</td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PubChem: </span></td><td><a href="https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=7847386">7847386</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">ChEBI: </span></td><td><a href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:119915">119915</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">PDB-CCD: </span></td><td><a href="https://www.ebi.ac.uk/pdbe-srv/pdbechem/chemicalCompound/show/7V7">7V7</a>[<a href="https://pdbj.org/mine/summary/7V7">PDBj</a>] </td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">LigandBox: </span></td><td><a href="http://www.mypresto5.com/ligandbox202210/cgi-bin/liginf.cgi?id=D00320&source=KEGG_DRUG">D00320</a></td></tr></table><table class="w1"><tr><td class="vtop pd0"><span class="nowrap">NIKKAJI: </span></td><td><a href="https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.736C">J5.736C</a></td></tr></table></td></tr> <tr><th class="th50 deft tal vmid"><span class="nowrap">LinkDB</span></th> <td class="td50 defd"><button class="btn" onclick="location.href='https://www.genome.jp/dbget-bin/get_linkdb?drug+D00320';return false;">All DBs</button></td></tr> <tr><th class="th51 deft tal vtop"><span class="nowrap">KCF data</span></th> <td class="td51 defd"><button class="btn" id="kcfb1">Show</button><div class="kcfd" id="kcfd1"><br>ATOM 25<br> 1 N1c N 28.2800 -14.2100<br> 2 C1y C 29.5400 -14.9100<br> 3 C8y C 27.0900 -14.9100<br> 4 C5a C 28.2800 -12.8100<br> 5 C1x C 29.5400 -16.3100<br> 6 C1x C 30.7300 -14.2100<br> 7 C8x C 25.9000 -14.2100<br> 8 C8x C 27.0900 -16.3100<br> 9 C1b C 29.5400 -12.1100<br> 10 O5a O 27.0900 -12.1100<br> 11 C1x C 30.7300 -17.0100<br> 12 C1x C 31.9200 -14.9100<br> 13 C8x C 24.6400 -14.9100<br> 14 C8x C 25.8300 -17.0100<br> 15 C1a C 30.7300 -12.8100<br> 16 N1y N 31.9200 -16.3100<br> 17 C8x C 24.6400 -16.2400<br> 18 C1b C 33.1800 -17.0100<br> 19 C1b C 34.3700 -16.3100<br> 20 C8y C 35.5600 -17.0100<br> 21 C8x C 35.5600 -18.4100<br> 22 C8x C 36.8200 -16.3100<br> 23 C8x C 36.8200 -19.1100<br> 24 C8x C 38.0100 -17.0100<br> 25 C8x C 38.0100 -18.4100<br> BOND 27<br> 1 1 2 1<br> 2 1 3 1<br> 3 1 4 1<br> 4 2 5 1<br> 5 2 6 1<br> 6 3 7 2<br> 7 3 8 1<br> 8 4 9 1<br> 9 4 10 2<br> 10 5 11 1<br> 11 6 12 1<br> 12 7 13 1<br> 13 8 14 2<br> 14 9 15 1<br> 15 11 16 1<br> 16 13 17 2<br> 17 16 18 1<br> 18 18 19 1<br> 19 19 20 1<br> 20 20 21 1<br> 21 20 22 2<br> 22 21 23 2<br> 23 22 24 1<br> 24 23 25 1<br> 25 12 16 1<br> 26 14 17 1<br> 27 24 25 2<br> </div></td></tr> </table></td></tr></table> <br><span style="font-size:12px"><a href="/entry/dr_ja:D00320">» Japanese version</a> <a href="javascript:history.back();">» Back</a></span><br><br></td></tr></table> <a href="/dbget/">DBGET</a> integrated 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