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post-231895 post type-post status-publish format-standard has-post-thumbnail hentry category-all-posts category-controlled-release category-dug-bioavailability category-main-blog category-peptide tag-controlled-release tag-dosage-form tag-drug-delivery tag-drug-development tag-drug-product tag-drug-product-development tag-formulation tag-lifecycle-management tag-model-based-drug-development tag-nano-particle tag-nanodelivery tag-next-generation tag-oral-bioavailability tag-oral-drug tag-oral-formulation tag-parenteral tag-pharma tag-prodrug tag-reformulation tag-solid-dispersion tag-solid-form tag-transdermal"> <div class="et_post_meta_wrapper"> <h1 class="entry-title">Prodrug Approach for Improving Bioavailability</h1> <p class="post-meta"><span class="published">Jul 7, 2021</span> | <a href="https://curtiscoulter.com/category/all-posts/" rel="category tag">All Posts</a>, <a href="https://curtiscoulter.com/category/controlled-release/" rel="category tag">Controlled Release</a>, <a href="https://curtiscoulter.com/category/dug-bioavailability/" rel="category tag">Drug Bioavailability</a>, <a href="https://curtiscoulter.com/category/main-blog/" rel="category tag">Main Blog</a>, <a href="https://curtiscoulter.com/category/peptide/" rel="category tag">Peptide</a> | <span class="comments-number"><a href="https://curtiscoulter.com/a-prodrug-approach-for-improving-bioavailabilitynanoparticle-formulation-modalities/#respond">0 comments</a></span></p><img src="https://curtiscoulter.wpenginepowered.com/wp-content/uploads/2020/04/Screen-Shot-2020-04-26-at-9.27.44-PM-1080x675.png" alt="" class="" width="1080" height="675" /> </div>  <div class="entry-content"> <div id="et-boc" class="et-boc"> <div class="et-l et-l--post"> <div class="et_builder_inner_content et_pb_gutters3"> <div class="et_pb_section et_pb_section_0 et_section_regular" > <div class="et_pb_row et_pb_row_0"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_0 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_0 et_pb_text_align_left et_pb_bg_layout_light"> <div class="et_pb_text_inner"><p>A prodrug is a medication or compound that metabolizes into a pharmacologically active drug after administration, offering opportunities to optimize the pharmaceutical property to improve bioavailability. Approximately 10% of all marketed drugs worldwide can be considered prodrugs. However, there are challenges for developing prodrugs.</p> <p>The therapeutic rationale of a prodrug is to improve the physicochemical, biopharmaceutical, or pharmacokinetic properties of an active pharmaceutical ingredient (API). Key properties that prodrugs seek to modify generally fall within one or more of the ADME categories (Absorption, Distribution, Metabolism, and Excretion) with the end goal being the creation of a new chemical entity (NCE) that optimizes the performance, utility, and potential life-cycle management of the parent drug. </p> <p>This week’s shared presentation is titled “A Prodrug Approach for Improving Bioavailability” from Dedong Wu at AstraZeneca. Dedong delivered this talk at our past Global Drug Bioavailability Summits earlier this year. This deck will give a brief introduction of the prodrug concept, intrinsic solubility improvement by prodrugs, as well as permeability enhancement by prodrugs. It additionally discusses in vivo molecule stability optimization by prodrugs and perspectives of prodrug design with examples. Scroll through the presentation below…</p></div> </div> <div class="et_pb_module et_pb_code et_pb_code_0 et_pb_text_align_center"> <div class="et_pb_code_inner"><iframe src="https://drive.google.com/file/d/1hAfm6P5VE_iA21fWmgAffuzE3dQ2H47X/preview" width="740" height="540"></iframe></div> </div>  </div>  </div>  </div> <div class="et_pb_section et_pb_section_2 et_pb_section_parallax et_section_regular" > <div class="et_pb_row et_pb_row_1 et_pb_equal_columns et_pb_gutters2"> <div class="et_pb_column et_pb_column_4_4 et_pb_column_1 et_pb_css_mix_blend_mode_passthrough et-last-child"> <div class="et_pb_module et_pb_text et_pb_text_1 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h3 style="text-align: center;"><span style="color: #000000;">2024 Controlled & Modified Drug Release Summit</span></h3> <h3 style="text-align: center;"><span style="color: #000000;">(May 14-15, 2024, Princeton, NJ)</span></h3> <p> </p></div> </div> <div class="et_pb_module et_pb_text et_pb_text_2 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h2><span style="font-size: medium;"><span style="color: #000000; text-align: justify; font-family: 'Open Sans', Helvetica, Arial, Lucida, sans-serif;"><span style="font-size: medium; color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif;"><b>Interested to improve the performance of your drug products? Learn 2 years of new drug product development approaches at the 2024 Summit this </b></span><span style="color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif; font-size: medium;"><b>coming</b></span><span style="font-size: medium; color: #000000; font-family: Open Sans, Helvetica, Arial, Lucida, sans-serif;"><b> May both in-person & virtual.</b></span></span></span></h2></div> </div>  </div>  </div> <div class="et_pb_row et_pb_row_2 et_pb_equal_columns et_pb_gutters2"> <div class="et_pb_column et_pb_column_1_2 et_pb_column_2 et_pb_css_mix_blend_mode_passthrough"> <div class="et_pb_module et_pb_text et_pb_text_3 et_pb_text_align_justified et_pb_bg_layout_dark"> <div class="et_pb_text_inner"><h2 style="text-align: left;"><span style="color: #000000; font-size: large; font-family: inherit; font-weight: normal;">Join 160+ leading drug delivery, formulation and development experts and hear 30+ expert sessions. Gain over 2 years worth of new drug product development strategies, formulation approaches, delivery technologies and regulatory updates while decreasing drug product time-to-market in just 2 short days (all available on-demand)!</span></h2> <h2 style="text-align: left;"><span style="color: #000000; font-size: large; font-family: inherit; font-weight: normal;">Save up-to 45% on attendance before Friday 29th September, 2023. Likewise, have a platform technology you would like to explore showcasing to the wider audience this May? 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