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vendar ni obvezna [o]" accesskey="o" class=""><span>Prijava</span></a> </li> </ul> </div> </div> </div> <div id="vector-user-links-dropdown" class="vector-dropdown vector-user-menu vector-button-flush-right vector-user-menu-logged-out" title="Več možnosti" > <input type="checkbox" id="vector-user-links-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-user-links-dropdown" class="vector-dropdown-checkbox " aria-label="Osebna orodja" > <label id="vector-user-links-dropdown-label" for="vector-user-links-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-ellipsis mw-ui-icon-wikimedia-ellipsis"></span> <span class="vector-dropdown-label-text">Osebna orodja</span> </label> <div class="vector-dropdown-content"> <div id="p-personal" class="vector-menu mw-portlet mw-portlet-personal 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class="vector-column-start"> <div class="vector-main-menu-container"> <div id="mw-navigation"> <nav id="mw-panel" class="vector-main-menu-landmark" aria-label="Projekt"> <div id="vector-main-menu-pinned-container" class="vector-pinned-container"> </div> </nav> </div> </div> <div class="vector-sticky-pinned-container"> <nav id="mw-panel-toc" aria-label="Vsebina" data-event-name="ui.sidebar-toc" class="mw-table-of-contents-container vector-toc-landmark"> <div id="vector-toc-pinned-container" class="vector-pinned-container"> <div id="vector-toc" class="vector-toc vector-pinnable-element"> <div class="vector-pinnable-header vector-toc-pinnable-header vector-pinnable-header-pinned" data-feature-name="toc-pinned" data-pinnable-element-id="vector-toc" > <h2 class="vector-pinnable-header-label">Vsebina</h2> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-toc.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-toc.unpin">skrij</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Uvod</div> </a> </li> <li id="toc-Mehanizem_delovanja" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Mehanizem_delovanja"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Mehanizem delovanja</span> </div> </a> <ul id="toc-Mehanizem_delovanja-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Raba_v_medicini" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Raba_v_medicini"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Raba v medicini</span> </div> </a> <ul id="toc-Raba_v_medicini-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Kontraindikacije" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Kontraindikacije"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Kontraindikacije</span> </div> </a> <ul id="toc-Kontraindikacije-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Neželeni_učinki" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Neželeni_učinki"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Neželeni učinki</span> </div> </a> <button aria-controls="toc-Neželeni_učinki-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Vklopi podrazdelek Neželeni učinki</span> </button> <ul id="toc-Neželeni_učinki-sublist" class="vector-toc-list"> <li id="toc-Neželeni_učinki_na_srce" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Neželeni_učinki_na_srce"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Neželeni učinki na srce</span> </div> </a> <ul id="toc-Neželeni_učinki_na_srce-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Gastrointestinalni_neželeni_učinki" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Gastrointestinalni_neželeni_učinki"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Gastrointestinalni neželeni učinki</span> </div> </a> <ul id="toc-Gastrointestinalni_neželeni_učinki-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Jetrni_neželeni_učinki" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Jetrni_neželeni_učinki"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.3</span> <span>Jetrni neželeni učinki</span> </div> </a> <ul id="toc-Jetrni_neželeni_učinki-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Ledvični_neželeni_učinki" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Ledvični_neželeni_učinki"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.4</span> <span>Ledvični neželeni učinki</span> </div> </a> <ul id="toc-Ledvični_neželeni_učinki-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Vplivi_na_duševno_zdravje" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Vplivi_na_duševno_zdravje"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.5</span> <span>Vplivi na duševno zdravje</span> </div> </a> <ul id="toc-Vplivi_na_duševno_zdravje-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Drugi_neželeni_učinki" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Drugi_neželeni_učinki"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.6</span> <span>Drugi neželeni učinki</span> </div> </a> <ul id="toc-Drugi_neželeni_učinki-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Sklici" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Sklici"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Sklici</span> </div> </a> <ul id="toc-Sklici-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Vsebina" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Vklopi kazalo vsebine" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Vklopi kazalo vsebine</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Diklofenak</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="P9jdi na članek v drugem jeziku. Na voljo v 52 jezikih." > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-52" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">52 jezikov</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Diklofenak" title="Diklofenak – afrikanščina" lang="af" hreflang="af" data-title="Diklofenak" data-language-autonym="Afrikaans" data-language-local-name="afrikanščina" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%AF%D9%8A%D9%83%D9%84%D9%88%D9%81%D9%8A%D9%86%D8%A7%D9%83" title="ديكلوفيناك – arabščina" lang="ar" hreflang="ar" data-title="ديكلوفيناك" data-language-autonym="العربية" data-language-local-name="arabščina" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-ast mw-list-item"><a href="https://ast.wikipedia.org/wiki/Diclofenaco" title="Diclofenaco – asturijščina" lang="ast" hreflang="ast" data-title="Diclofenaco" data-language-autonym="Asturianu" data-language-local-name="asturijščina" class="interlanguage-link-target"><span>Asturianu</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%AF%DB%8C%DA%A9%D9%84%D9%88%D9%81%D9%86%D8%A7%DA%A9" title="دیکلوفناک – South Azerbaijani" lang="azb" hreflang="azb" data-title="دیکلوفناک" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%94%D0%B8%D0%BA%D0%BB%D0%BE%D1%84%D0%B5%D0%BD%D0%B0%D0%BA" title="Диклофенак – bolgarščina" lang="bg" hreflang="bg" data-title="Диклофенак" data-language-autonym="Български" data-language-local-name="bolgarščina" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%A1%E0%A6%BE%E0%A6%87%E0%A6%95%E0%A7%8D%E0%A6%B2%E0%A7%8B%E0%A6%AB%E0%A7%87%E0%A6%A8%E0%A6%BE%E0%A6%95" title="ডাইক্লোফেনাক – bengalščina" lang="bn" hreflang="bn" data-title="ডাইক্লোফেনাক" data-language-autonym="বাংলা" data-language-local-name="bengalščina" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Diklofenak" title="Diklofenak – bosanščina" lang="bs" hreflang="bs" data-title="Diklofenak" data-language-autonym="Bosanski" data-language-local-name="bosanščina" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Diclofenac" title="Diclofenac – katalonščina" lang="ca" hreflang="ca" data-title="Diclofenac" data-language-autonym="Català" data-language-local-name="katalonščina" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Dicloffenac" title="Dicloffenac – valižanščina" lang="cy" hreflang="cy" data-title="Dicloffenac" data-language-autonym="Cymraeg" data-language-local-name="valižanščina" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Diclofenac" title="Diclofenac – nemščina" lang="de" hreflang="de" data-title="Diclofenac" data-language-autonym="Deutsch" data-language-local-name="nemščina" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%94%CE%B9%CE%BA%CE%BB%CE%BF%CF%86%CE%B1%CE%B9%CE%BD%CE%AC%CE%BA%CE%B7" title="Δικλοφαινάκη – grščina" lang="el" hreflang="el" data-title="Δικλοφαινάκη" data-language-autonym="Ελληνικά" data-language-local-name="grščina" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Diclofenac" title="Diclofenac – angleščina" lang="en" hreflang="en" data-title="Diclofenac" data-language-autonym="English" data-language-local-name="angleščina" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-eo mw-list-item"><a href="https://eo.wikipedia.org/wiki/Diklofenako" title="Diklofenako – esperanto" lang="eo" hreflang="eo" data-title="Diklofenako" data-language-autonym="Esperanto" data-language-local-name="esperanto" class="interlanguage-link-target"><span>Esperanto</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Diclofenaco" title="Diclofenaco – španščina" lang="es" hreflang="es" data-title="Diclofenaco" data-language-autonym="Español" data-language-local-name="španščina" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Diklofenako" title="Diklofenako – baskovščina" lang="eu" hreflang="eu" data-title="Diklofenako" data-language-autonym="Euskara" data-language-local-name="baskovščina" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%AF%DB%8C%DA%A9%D9%84%D9%88%D9%81%D9%86%D8%A7%DA%A9" title="دیکلوفناک – perzijščina" lang="fa" hreflang="fa" data-title="دیکلوفناک" data-language-autonym="فارسی" data-language-local-name="perzijščina" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Diklofenaakki" title="Diklofenaakki – finščina" lang="fi" hreflang="fi" data-title="Diklofenaakki" data-language-autonym="Suomi" data-language-local-name="finščina" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Diclof%C3%A9nac" title="Diclofénac – francoščina" lang="fr" hreflang="fr" data-title="Diclofénac" data-language-autonym="Français" data-language-local-name="francoščina" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ga mw-list-item"><a href="https://ga.wikipedia.org/wiki/Diclofenac" title="Diclofenac – irščina" lang="ga" hreflang="ga" data-title="Diclofenac" data-language-autonym="Gaeilge" data-language-local-name="irščina" class="interlanguage-link-target"><span>Gaeilge</span></a></li><li class="interlanguage-link interwiki-guw mw-list-item"><a href="https://guw.wikipedia.org/wiki/Diclofenac" title="Diclofenac – Gun" lang="guw" hreflang="guw" data-title="Diclofenac" data-language-autonym="Gungbe" data-language-local-name="Gun" class="interlanguage-link-target"><span>Gungbe</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%93%D7%99%D7%A7%D7%9C%D7%95%D7%A4%D7%A0%D7%A7" title="דיקלופנק – hebrejščina" lang="he" hreflang="he" data-title="דיקלופנק" data-language-autonym="עברית" data-language-local-name="hebrejščina" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Diklofen%C3%A1k" title="Diklofenák – madžarščina" lang="hu" hreflang="hu" data-title="Diklofenák" data-language-autonym="Magyar" data-language-local-name="madžarščina" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B4%D5%AB%D5%AF%D5%AC%D5%B8%D6%86%D5%A5%D5%B6%D5%A1%D5%AF" title="Դիկլոֆենակ – armenščina" lang="hy" hreflang="hy" data-title="Դիկլոֆենակ" data-language-autonym="Հայերեն" data-language-local-name="armenščina" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Diklofenak" title="Diklofenak – indonezijščina" lang="id" hreflang="id" data-title="Diklofenak" data-language-autonym="Bahasa Indonesia" data-language-local-name="indonezijščina" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Diclofenac" title="Diclofenac – italijanščina" lang="it" hreflang="it" data-title="Diclofenac" data-language-autonym="Italiano" data-language-local-name="italijanščina" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%B8%E3%82%AF%E3%83%AD%E3%83%95%E3%82%A7%E3%83%8A%E3%82%AF" title="ジクロフェナク – japonščina" lang="ja" hreflang="ja" data-title="ジクロフェナク" data-language-autonym="日本語" data-language-local-name="japonščina" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-kk mw-list-item"><a href="https://kk.wikipedia.org/wiki/%D0%94%D0%B8%D0%BA%D0%BB%D0%BE%D1%84%D0%B5%D0%BD%D0%B0%D0%BA" title="Диклофенак – kazaščina" lang="kk" hreflang="kk" data-title="Диклофенак" data-language-autonym="Қазақша" data-language-local-name="kazaščina" class="interlanguage-link-target"><span>Қазақша</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EB%94%94%ED%81%B4%EB%A1%9C%ED%8E%98%EB%82%99" title="디클로페낙 – korejščina" lang="ko" hreflang="ko" data-title="디클로페낙" data-language-autonym="한국어" data-language-local-name="korejščina" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-ku mw-list-item"><a href="https://ku.wikipedia.org/wiki/D%C3%AEklofenak" title="Dîklofenak – kurdščina" lang="ku" hreflang="ku" data-title="Dîklofenak" data-language-autonym="Kurdî" data-language-local-name="kurdščina" class="interlanguage-link-target"><span>Kurdî</span></a></li><li class="interlanguage-link interwiki-lt mw-list-item"><a href="https://lt.wikipedia.org/wiki/Diklofenakas" title="Diklofenakas – litovščina" lang="lt" hreflang="lt" data-title="Diklofenakas" data-language-autonym="Lietuvių" data-language-local-name="litovščina" class="interlanguage-link-target"><span>Lietuvių</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Diklofenaks" title="Diklofenaks – latvijščina" lang="lv" hreflang="lv" data-title="Diklofenaks" data-language-autonym="Latviešu" data-language-local-name="latvijščina" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-ms mw-list-item"><a href="https://ms.wikipedia.org/wiki/Diklofenak" title="Diklofenak – malajščina" lang="ms" hreflang="ms" data-title="Diklofenak" data-language-autonym="Bahasa Melayu" data-language-local-name="malajščina" class="interlanguage-link-target"><span>Bahasa Melayu</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Diclofenac" title="Diclofenac – nizozemščina" lang="nl" hreflang="nl" data-title="Diclofenac" data-language-autonym="Nederlands" data-language-local-name="nizozemščina" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%A1%E0%AC%BE%E0%AC%87%E0%AC%95%E0%AD%8D%E0%AC%B2%E0%AD%8B%E0%AC%AB%E0%AD%87%E0%AC%A8%E0%AC%BE%E0%AC%95" title="ଡାଇକ୍ଲୋଫେନାକ – odijščina" lang="or" hreflang="or" data-title="ଡାଇକ୍ଲୋଫେନାକ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="odijščina" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pa mw-list-item"><a href="https://pa.wikipedia.org/wiki/%E0%A8%A1%E0%A8%BF%E0%A8%95%E0%A8%B2%E0%A9%8B%E0%A8%AB%E0%A9%87%E0%A8%A8%E0%A9%88%E0%A8%95" title="ਡਿਕਲੋਫੇਨੈਕ – pandžabščina" lang="pa" hreflang="pa" data-title="ਡਿਕਲੋਫੇਨੈਕ" data-language-autonym="ਪੰਜਾਬੀ" data-language-local-name="pandžabščina" class="interlanguage-link-target"><span>ਪੰਜਾਬੀ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Diklofenak" title="Diklofenak – poljščina" lang="pl" hreflang="pl" data-title="Diklofenak" data-language-autonym="Polski" data-language-local-name="poljščina" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-ps mw-list-item"><a href="https://ps.wikipedia.org/wiki/%D8%AF%D9%8A%DA%A9%D9%84%D9%88%D9%81%D9%8A%D9%86%D8%A7%DA%A9" title="ديکلوفيناک – paštunščina" lang="ps" hreflang="ps" data-title="ديکلوفيناک" data-language-autonym="پښتو" data-language-local-name="paštunščina" class="interlanguage-link-target"><span>پښتو</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Diclofenaco" title="Diclofenaco – portugalščina" lang="pt" hreflang="pt" data-title="Diclofenaco" data-language-autonym="Português" data-language-local-name="portugalščina" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Diclofenac" title="Diclofenac – romunščina" lang="ro" hreflang="ro" data-title="Diclofenac" data-language-autonym="Română" data-language-local-name="romunščina" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%94%D0%B8%D0%BA%D0%BB%D0%BE%D1%84%D0%B5%D0%BD%D0%B0%D0%BA" title="Диклофенак – ruščina" lang="ru" hreflang="ru" data-title="Диклофенак" data-language-autonym="Русский" data-language-local-name="ruščina" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Diklofenak" title="Diklofenak – srbohrvaščina" lang="sh" hreflang="sh" data-title="Diklofenak" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="srbohrvaščina" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-simple mw-list-item"><a href="https://simple.wikipedia.org/wiki/Diclofenac" title="Diclofenac – Simple English" lang="en-simple" hreflang="en-simple" data-title="Diclofenac" data-language-autonym="Simple English" data-language-local-name="Simple English" class="interlanguage-link-target"><span>Simple English</span></a></li><li class="interlanguage-link interwiki-sq mw-list-item"><a href="https://sq.wikipedia.org/wiki/Diklofenaku" title="Diklofenaku – albanščina" lang="sq" hreflang="sq" data-title="Diklofenaku" data-language-autonym="Shqip" data-language-local-name="albanščina" class="interlanguage-link-target"><span>Shqip</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/%D0%94%D0%B8%D0%BA%D0%BB%D0%BE%D1%84%D0%B5%D0%BD%D0%B0%D0%BA" title="Диклофенак – srbščina" lang="sr" hreflang="sr" data-title="Диклофенак" data-language-autonym="Српски / srpski" data-language-local-name="srbščina" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Diklofenak" title="Diklofenak – švedščina" lang="sv" hreflang="sv" data-title="Diklofenak" data-language-autonym="Svenska" data-language-local-name="švedščina" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%9F%E0%AF%88%E0%AE%95%E0%AF%8D%E0%AE%B3%E0%AF%8B%E0%AE%83%E0%AE%AA%E0%AF%80%E0%AE%A9%E0%AE%BE%E0%AE%95%E0%AF%8D" title="டைக்ளோஃபீனாக் – tamilščina" lang="ta" hreflang="ta" data-title="டைக்ளோஃபீனாக்" data-language-autonym="தமிழ்" data-language-local-name="tamilščina" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%84%E0%B8%94%E0%B9%82%E0%B8%84%E0%B8%A5%E0%B8%9F%E0%B8%B5%E0%B9%81%E0%B8%99%E0%B8%84" title="ไดโคลฟีแนค – tajščina" lang="th" hreflang="th" data-title="ไดโคลฟีแนค" data-language-autonym="ไทย" data-language-local-name="tajščina" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Diklofenak" title="Diklofenak – turščina" lang="tr" hreflang="tr" data-title="Diklofenak" data-language-autonym="Türkçe" data-language-local-name="turščina" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%94%D0%B8%D0%BA%D0%BB%D0%BE%D1%84%D0%B5%D0%BD%D0%B0%D0%BA" title="Диклофенак – ukrajinščina" lang="uk" hreflang="uk" data-title="Диклофенак" data-language-autonym="Українська" data-language-local-name="ukrajinščina" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-ur mw-list-item"><a href="https://ur.wikipedia.org/wiki/%DA%88%DA%A9%D9%84%D9%88%D9%81%DB%8C%D9%86%DA%A9" title="ڈکلوفینک – urdujščina" lang="ur" hreflang="ur" data-title="ڈکلوفینک" data-language-autonym="اردو" data-language-local-name="urdujščina" class="interlanguage-link-target"><span>اردو</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Diclofenac" title="Diclofenac – vietnamščina" lang="vi" hreflang="vi" data-title="Diclofenac" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamščina" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E5%8F%8C%E6%B0%AF%E8%8A%AC%E9%85%B8" title="双氯芬酸 – kitajščina" lang="zh" hreflang="zh" data-title="双氯芬酸" data-language-autonym="中文" data-language-local-name="kitajščina" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q244408#sitelinks-wikipedia" title="Uredi medjezikovne povezave" class="wbc-editpage">Uredi povezave</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Imenski prostori"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Diklofenak" title="Ogled vsebinske strani [c]" accesskey="c"><span>Stran</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Pogovor:Diklofenak" rel="discussion" title="Pogovor o vsebinski strani [t]" accesskey="t"><span>Pogovor</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Spremeni različico jezika" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">slovenščina</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> </ul> </div> </div> </div> </div> </nav> </div> <div id="right-navigation" class="vector-collapsible"> <nav aria-label="Pogledi"> <div id="p-views" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-views" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-view" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Diklofenak"><span>Preberi</span></a></li><li id="ca-ve-edit" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diklofenak&veaction=edit" title="Uredite to stran [v]" accesskey="v"><span>Uredi stran</span></a></li><li id="ca-edit" class="collapsible vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diklofenak&action=edit" title="Uredi izvorno kodo te strani [e]" accesskey="e"><span>Uredi kodo</span></a></li><li id="ca-history" class="vector-tab-noicon mw-list-item"><a href="/w/index.php?title=Diklofenak&action=history" title="Prejšnje redakcije te strani [h]" accesskey="h"><span>Zgodovina</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Orodja strani"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Orodja" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Orodja</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header vector-page-tools-pinnable-header vector-pinnable-header-unpinned" data-feature-name="page-tools-pinned" data-pinnable-element-id="vector-page-tools" data-pinned-container-id="vector-page-tools-pinned-container" data-unpinned-container-id="vector-page-tools-unpinned-container" > <div class="vector-pinnable-header-label">Orodja</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-page-tools.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-page-tools.unpin">skrij</button> </div> <div id="p-cactions" class="vector-menu mw-portlet mw-portlet-cactions emptyPortlet vector-has-collapsible-items" title="Več možnosti" > <div class="vector-menu-heading"> Dejanja </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-more-view" class="selected vector-more-collapsible-item mw-list-item"><a href="/wiki/Diklofenak"><span>Preberi</span></a></li><li id="ca-more-ve-edit" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Diklofenak&veaction=edit" title="Uredite to stran [v]" accesskey="v"><span>Uredi stran</span></a></li><li id="ca-more-edit" class="collapsible vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Diklofenak&action=edit" title="Uredi izvorno kodo te strani [e]" accesskey="e"><span>Uredi kodo</span></a></li><li id="ca-more-history" class="vector-more-collapsible-item mw-list-item"><a href="/w/index.php?title=Diklofenak&action=history"><span>Zgodovina</span></a></li> </ul> </div> </div> <div id="p-tb" class="vector-menu mw-portlet mw-portlet-tb" > <div class="vector-menu-heading"> Splošno </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="t-whatlinkshere" class="mw-list-item"><a href="/wiki/Posebno:KajSePovezujeSem/Diklofenak" title="Seznam vseh strani, ki se povezujejo sem [j]" accesskey="j"><span>Kaj se povezuje sem</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Posebno:RecentChangesLinked/Diklofenak" rel="nofollow" title="Zadnje spremembe na straneh, s katerimi se povezuje ta stran [k]" accesskey="k"><span>Povezane spremembe</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Posebno:PosebneStrani" title="Seznam vseh posebnih strani [q]" accesskey="q"><span>Posebne strani</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Diklofenak&oldid=6299396" title="Trajna povezava na to redakcijo strani"><span>Trajna povezava</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Diklofenak&action=info" title="Več informacij o tej strani"><span>Podatki o strani</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Posebno:Navedi&page=Diklofenak&id=6299396&wpFormIdentifier=titleform" title="Informacije o tem, kako navajati to stran"><span>Navedba članka</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Posebno:UrlShortener&url=https%3A%2F%2Fsl.wikipedia.org%2Fwiki%2FDiklofenak"><span>Pridobi skrajšani URL</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Posebno:QrCode&url=https%3A%2F%2Fsl.wikipedia.org%2Fwiki%2FDiklofenak"><span>Prenesi kodo QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Tiskanje/izvoz </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Posebno:Book&bookcmd=book_creator&referer=Diklofenak"><span>Ustvari e-knjigo</span></a></li><li id="coll-download-as-rl" class="mw-list-item"><a href="/w/index.php?title=Posebno:DownloadAsPdf&page=Diklofenak&action=show-download-screen"><span>Prenesi kot PDF</span></a></li><li id="t-print" class="mw-list-item"><a href="/w/index.php?title=Diklofenak&printable=yes" title="Različica te strani za tisk [p]" accesskey="p"><span>Različica za tisk</span></a></li> </ul> </div> </div> <div id="p-wikibase-otherprojects" class="vector-menu mw-portlet mw-portlet-wikibase-otherprojects" > <div class="vector-menu-heading"> V drugih projektih </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="wb-otherproject-link wb-otherproject-commons mw-list-item"><a href="https://commons.wikimedia.org/wiki/Category:Diclofenac" hreflang="en"><span>Wikimedijina zbirka</span></a></li><li id="t-wikibase" class="wb-otherproject-link wb-otherproject-wikibase-dataitem mw-list-item"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q244408" title="Povezava na ustrezni predmet v podatkovni shrambi [g]" accesskey="g"><span>Predmet v Wikipodatkih</span></a></li> </ul> </div> </div> </div> </div> </div> </div> </nav> </div> </div> </div> <div class="vector-column-end"> <div class="vector-sticky-pinned-container"> <nav class="vector-page-tools-landmark" aria-label="Orodja strani"> <div id="vector-page-tools-pinned-container" class="vector-pinned-container"> </div> </nav> <nav class="vector-appearance-landmark" aria-label="Videz"> <div id="vector-appearance-pinned-container" class="vector-pinned-container"> <div id="vector-appearance" class="vector-appearance vector-pinnable-element"> <div class="vector-pinnable-header vector-appearance-pinnable-header vector-pinnable-header-pinned" data-feature-name="appearance-pinned" data-pinnable-element-id="vector-appearance" data-pinned-container-id="vector-appearance-pinned-container" data-unpinned-container-id="vector-appearance-unpinned-container" > <div class="vector-pinnable-header-label">Videz</div> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-pin-button" data-event-name="pinnable-header.vector-appearance.pin">prestavi v stransko letvico</button> <button class="vector-pinnable-header-toggle-button vector-pinnable-header-unpin-button" data-event-name="pinnable-header.vector-appearance.unpin">skrij</button> </div> </div> </div> </nav> </div> </div> <div id="bodyContent" class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">Iz Wikipedije, proste enciklopedije</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="sl" dir="ltr"><style data-mw-deduplicate="TemplateStyles:r5913888">.mw-parser-output .infobox{border:1px solid #a2a9b1;border-spacing:3px;background-color:#f8f9fa;color:black;margin:0.5em 0 0.5em 1em;padding:0.2em;float:right;clear:right;font-size:88%;line-height:1.5em;width:22em}.mw-parser-output .infobox-header,.mw-parser-output .infobox-label,.mw-parser-output .infobox-above,.mw-parser-output .infobox-full-data,.mw-parser-output .infobox-data,.mw-parser-output .infobox-below,.mw-parser-output .infobox-subheader,.mw-parser-output .infobox-image,.mw-parser-output .infobox-navbar,.mw-parser-output .infobox th,.mw-parser-output .infobox td{vertical-align:top}.mw-parser-output .infobox-label,.mw-parser-output .infobox-data,.mw-parser-output .infobox th,.mw-parser-output .infobox td{text-align:left}.mw-parser-output .infobox .infobox-header,.mw-parser-output .infobox .infobox-subheader,.mw-parser-output .infobox .infobox-image,.mw-parser-output .infobox .infobox-full-data,.mw-parser-output .infobox .infobox-below{text-align:center}.mw-parser-output .infobox .infobox-above,.mw-parser-output .infobox .infobox-title,.mw-parser-output .infobox caption{font-size:125%;font-weight:bold;text-align:center}.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}body.skin-minerva .mw-parser-output .infobox-header,body.skin-minerva .mw-parser-output .infobox-subheader,body.skin-minerva .mw-parser-output .infobox-above,body.skin-minerva .mw-parser-output .infobox-title,body.skin-minerva .mw-parser-output .infobox-image,body.skin-minerva .mw-parser-output .infobox-full-data,body.skin-minerva .mw-parser-output .infobox-below{text-align:center}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="Mednarodno nezaščiteno ime (INN): Diklofenak">Diklofenak</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/Slika:Diclofenac.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Diclofenac.svg/200px-Diclofenac.svg.png" decoding="async" width="200" height="154" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Diclofenac.svg/300px-Diclofenac.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Diclofenac.svg/400px-Diclofenac.svg.png 2x" data-file-width="265" data-file-height="204" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span typeof="mw:File"><a href="/wiki/Slika:Diclofenac_3D_2ek.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Diclofenac_3D_2ek.png/200px-Diclofenac_3D_2ek.png" decoding="async" width="200" height="268" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Diclofenac_3D_2ek.png/300px-Diclofenac_3D_2ek.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Diclofenac_3D_2ek.png/400px-Diclofenac_3D_2ek.png 2x" data-file-width="1000" data-file-height="1339" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Klinični podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">Blagovne znamke</th><td class="infobox-data">Aclonac, Cataflam, Voltaren</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=American_Society_of_Health-System_Pharmacists&action=edit&redlink=1" class="new" title="American Society of Health-System Pharmacists (stran ne obstaja)">AHFS</a>/<a href="/w/index.php?title=Drugs.com&action=edit&redlink=1" class="new" title="Drugs.com (stran ne obstaja)">Drugs.com</a></th><td class="infobox-data"><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/diclofenac-epolamine.html">monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a689002.html">a689002</a></span></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Zdravila_in_nose%C4%8Dnost" class="mw-redirect" title="Zdravila in nosečnost">Nosečnostna<br />kategorija</a></th><td class="infobox-data"><div class="plainlist"> <ul><li><small><span class="abbr" style="border-bottom: 1px dotted" title="Avstralija">AU</span>:</small> <a href="/wiki/Nose%C4%8Dnostna_kategorija#Avstralija" title="Nosečnostna kategorija">C</a> </li></ul> <ul><li>C (1. in 2. trimesečje), D (3. trimesečje)</li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Na%C4%8Din_uporabe_zdravila" class="mw-redirect" title="Način uporabe zdravila">Način uporabe</a></th><td class="infobox-data">peroralno, rektalno, intramuskularno, intravensko, topično</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Anatomsko-terapevtsko-kemi%C4%8Dni_klasifikacijski_sistem" title="Anatomsko-terapevtsko-kemični klasifikacijski sistem">Oznaka ATC</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r5911185">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"><ul><li><a href="/w/index.php?title=ATC-koda_D11&action=edit&redlink=1" class="new" title="ATC-koda D11 (stran ne obstaja)">D11AX18</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=D11AX18">WHO</a></span>) <a href="/w/index.php?title=ATC-koda_M01&action=edit&redlink=1" class="new" title="ATC-koda M01 (stran ne obstaja)">M01</a><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=M01AB05">AB05</a></span>, <a href="/w/index.php?title=ATC-koda_M02&action=edit&redlink=1" class="new" title="ATC-koda M02 (stran ne obstaja)">M02</a><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=M02AA15">AA15</a></span>, <a href="/w/index.php?title=ATC-koda_S01&action=edit&redlink=1" class="new" title="ATC-koda S01 (stran ne obstaja)">S01</a><span class="reflink plainlinks nourlexpansion"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=S01BC03">BC03</a></span></li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Pravni status</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">Pravni status</th><td class="infobox-data"><div class="plainlist"> <ul><li><small><span class="abbr" style="border-bottom: 1px dotted" title="Avstralija">AU</span>:</small> <a href="/w/index.php?title=Standard_for_the_Uniform_Scheduling_of_Drugs_and_Poisons&action=edit&redlink=1" class="new" title="Standard for the Uniform Scheduling of Drugs and Poisons (stran ne obstaja)">S4</a> (le na recept) </li> <li><small><span class="abbr" style="border-bottom: 1px dotted" title="Združeno Kraljestvo">UK</span>:</small> <a href="/w/index.php?title=Pharmacy_medicines&action=edit&redlink=1" class="new" title="Pharmacy medicines (stran ne obstaja)">Pharmacy medicines</a> </li> <li>Rx-only most preparations/countries, limited OTC in some countries, manufacture and veterinary use is banned in India, Nepal, and Pakistan due to imminent extinction of local vultures</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd"><a href="/wiki/Farmakokinetika" title="Farmakokinetika">Farmakokinetični</a> podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Vezava_na_plazemske_beljakovine" title="Vezava na plazemske beljakovine">Vezava na beljakovine</a></th><td class="infobox-data">več kot 99 %</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Presnova_u%C4%8Dinkovine" title="Presnova učinkovine">Presnova</a></th><td class="infobox-data">jetrna presnova, aktivnih presnovkov ni</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Biolo%C5%A1ki_razpolovni_%C4%8Das&action=edit&redlink=1" class="new" title="Biološki razpolovni čas (stran ne obstaja)">Razpolovni čas</a></th><td class="infobox-data">1,2–2 h (35 % odmerka vstopi v enterohepatično recirkulacijo)</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Izlo%C4%8Danje" title="Izločanje">Izločanje</a></th><td class="infobox-data">40 % z <a href="/wiki/%C5%BDol%C4%8D" title="Žolč">žolčem</a>, 60 % s <a href="/wiki/Se%C4%8D" title="Seč">sečem</a></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Identifikatorji</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Nomenklatura_Mednarodne_zveze_za_%C4%8Disto_in_uporabno_kemijo" class="mw-redirect" title="Nomenklatura Mednarodne zveze za čisto in uporabno kemijo">IUPAC ime</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><span style="font-size: 11px;">2-(2-(2,6-diklorofenilamino)fenil)ocetna kislina</span></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/%C5%A0tevilka_CAS" title="Številka CAS">Številka CAS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.commonchemistry.org"><a rel="nofollow" class="external text" href="http://www.commonchemistry.org/ChemicalDetail.aspx?ref=15307-86-5">15307-86-5</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><span class="abbr" style="border-bottom: 1px dotted" title="Compound ID">CID</span></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/3033">3033</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Guide_to_Pharmacology&action=edit&redlink=1" class="new" title="Guide to Pharmacology (stran ne obstaja)">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="http://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=2714">2714</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=DrugBank&action=edit&redlink=1" class="new" title="DrugBank (stran ne obstaja)">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00586">DB00586</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="http://www.chemspider.com/Chemical-Structure.2925.html">2925</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Unique_Ingredient_Identifier&action=edit&redlink=1" class="new" title="Unique Ingredient Identifier (stran ne obstaja)">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="fdasis.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://fdasis.nlm.nih.gov/srs/srsdirect.jsp?regno=144O8QL0L1">144O8QL0L1</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="http://www.kegg.jp/entry/D07816">D07816</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:47381">CHEBI:47381</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/ChEMBL139">ChEMBL139</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/w/index.php?title=Protein_Data_Bank&action=edit&redlink=1" class="new" title="Protein Data Bank (stran ne obstaja)">PDB</a> <a href="/w/index.php?title=Ligand_(biochemistry)&action=edit&redlink=1" class="new" title="Ligand (biochemistry) (stran ne obstaja)">ligand</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li>DIF (<span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=DIF">PDBe</a></span>, <span title="www.rcsb.org"><a rel="nofollow" class="external text" href="http://www.rcsb.org/pdb/search/smartSubquery.do?smartSearchSubtype=ChemCompIdQuery&chemCompId=DIF&polymericType=Any">RCSB PDB</a></span>)</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<span class="abbr" style="border-bottom: 1px dotted" title="U.S. Environmental Protection Agency">EPA</span>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/DTXSID6022923">DTXSID6022923</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q244408#P3117" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.035.755">100.035.755</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q244408#P2566" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd">Kemični in fizikalni podatki</th></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Kemi%C4%8Dna_formula" class="mw-redirect" title="Kemična formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>14</sub><span title="Vodik">H</span><sub>11</sub><span title="Klor">Cl</span><sub>2</sub><span title="Dušik">N</span><span title="Kisik">O</span><sub>2</sub></td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;"><a href="/wiki/Molekulska_masa" title="Molekulska masa">Mol. masa</a></th><td class="infobox-data">296,148 g/mol</td></tr><tr><th scope="row" class="infobox-label" style="padding:0.2em 0; line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5911185"><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=O%3DC%28O%29Cc1ccccc1Nc2c%28Cl%29cccc2Cl.OCCN1CCCC1">Interactive image</a></span></li></ul></div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">O=C(O)Cc1ccccc1Nc2c(Cl)cccc2Cl.OCCN1CCCC1</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" class="mw-redirect" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">InChI=1S/C14H11Cl2NO2/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19/h1-7,17H,8H2,(H,18,19)</div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:11px; line-height:120%;">Key:DCOPUUMXTXDBNB-UHFFFAOYSA-N</div></li></ul> </div></td></tr></tbody></table> <p><b>Diklofenak</b> je <a href="/wiki/Nesteroidno_protivnetno_zdravilo" class="mw-redirect" title="Nesteroidno protivnetno zdravilo">nesteroidno protivnetno zdravilo</a>, ki se uporablja za zmanjšanje <a href="/wiki/Vnetje" title="Vnetje">vnetij</a>, kot <a href="/wiki/Analgetik" title="Analgetik">analgetik</a> (protibolečinska učinkovina) in <a href="/wiki/Antipiretik" title="Antipiretik">antipiretik</a> (za zniževanje povišane telesne temperature). Je derivat <a href="/w/index.php?title=Aminofenilocetna_kislina&action=edit&redlink=1" class="new" title="Aminofenilocetna kislina (stran ne obstaja)">aminofenilocetne kisline</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Zdravilo tržijo pod različnimi trgovskimi imeni, v Sloveniji na primer pod imeni <i>Diclo Duo</i>, <i>DicloFlex</i>, <i>Naklofen</i>, <i>Olfen</i>, <i>Voltaren</i> ...<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> Ime diklofenak izhaja iz kemijskega imena 2- 2,6-dikloranilino)fenilocetna kislina (angl. 2-(2,6-<b>dichlo</b>ranilino) <b>phen</b>ylacetic <b>ac</b>id). Razvilo ga je podjetje Ciba-Geigy (današnji Novartis) leta 1973.<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup> Leta 1979 pa je bil prvič predstavljen v Veliki Britaniji.<sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p><p>V <a href="/wiki/Zdru%C5%BEeno_kraljestvo_Velike_Britanije_in_Severne_Irske" title="Združeno kraljestvo Velike Britanije in Severne Irske">Veliki Britaniji</a>, <a href="/wiki/Indija" title="Indija">Indiji</a>, <a href="/wiki/Brazilija" title="Brazilija">Braziliji</a> in <a href="/wiki/ZDA" class="mw-redirect" title="ZDA">Združenih državah Amerike</a> se lahko diklofenak trži kot <a href="/wiki/Natrij" title="Natrij">natrijeva</a> ali <a href="/wiki/Kalij" title="Kalij">kalijeva</a> sol, na <a href="/wiki/Ljudska_republika_Kitajska" title="Ljudska republika Kitajska">Kitajskem</a> je najpogosteje na voljo kot natrijeva sol, v nekaterih drugih državah pa je na voljo izključno v obliki kalijeve soli. Proizvajajo ga kot generično zdravilo, brez zdravniškega recepta je v nekaterih državah dostopen za lajšanje blažjih bolečin in zniževanje telesne temperature. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Mehanizem_delovanja">Mehanizem delovanja</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=1" title="Uredi razdelek: Mehanizem delovanja" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=1" title="Urejanje izvorne kode razdelka: Mehanizem delovanja"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Diklofenak je <a href="/wiki/Nesteroidni_antirevmatik" class="mw-redirect" title="Nesteroidni antirevmatik">nesteroidni antirevmatik</a>. Deluje protibolečinsko, protivnetno in protivročinsko. Zavira delovanje <a href="/wiki/Encim" title="Encim">encima</a> <a href="/wiki/Ciklooksigenaza" title="Ciklooksigenaza">ciklooksigenaza</a> in s tem sintezo <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandinov</a>. Med zdravljenjem z diklofenakom so ugotovili znižano koncentracijo prostaglandinov v <a href="/wiki/Se%C4%8D" title="Seč">seču</a>, <a href="/w/index.php?title=%C5%BDelod%C4%8Dna_sluznica&action=edit&redlink=1" class="new" title="Želodčna sluznica (stran ne obstaja)">želodčni sluznici</a> in <a href="/w/index.php?title=Sinovialna_teko%C4%8Dina&action=edit&redlink=1" class="new" title="Sinovialna tekočina (stran ne obstaja)">sinovialni tekočini</a>.<sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> Zavira neselektivno obe izoobliki encima, ciklooksigenazo 1 (COX-1) in ciklooksigenazo 2 (COX-2). Zaviranje izooblike COX-2, ki jo normalno izražajo aktivirani <a href="/wiki/Makrofag" title="Makrofag">makrofagi</a> in inducirajo provnetne snovi, prispeva k protivnetnemu, protibolečinskemu in antipiretičnemu učinku, medtem ko zaviranje COX-1 povzroča večino <a href="/wiki/Ne%C5%BEeleni_u%C4%8Dinek" class="mw-redirect" title="Neželeni učinek">neželenih učinkov</a>, npr. gastrointestinalne krvavitve in razjede ter disfunkcijo <a href="/wiki/Trombocit" title="Trombocit">trombocitov</a>.<sup id="cite_ref-Ravnikar_7-0" class="reference"><a href="#cite_note-Ravnikar-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Raba_v_medicini">Raba v medicini</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=2" title="Uredi razdelek: Raba v medicini" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=2" title="Urejanje izvorne kode razdelka: Raba v medicini"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Diklofenak se uporablja za zdravljenje bolečine, vnetnih sprememb in dismenoreje.<sup id="cite_ref-AHFS_8-0" class="reference"><a href="#cite_note-AHFS-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> </p><p>Diklofenak je na tržišču tudi v obliki <a href="/wiki/Gel" title="Gel">gelov</a> za <a href="/wiki/Topi%C4%8Dna_uporaba_zdravila" title="Topična uporaba zdravila">topično uporabo</a> za zdravljenje simptomov <a href="/wiki/Osteoartritis" class="mw-redirect" title="Osteoartritis">osteoartritisa</a> in <a href="/w/index.php?title=Aktini%C4%8Dna_keratoza&action=edit&redlink=1" class="new" title="Aktinična keratoza (stran ne obstaja)">aktinične keratoze</a> ter lajšanje blažjih bolečin, na primer pri zvinih in udarcih .<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Kontraindikacije">Kontraindikacije</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=3" title="Uredi razdelek: Kontraindikacije" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=3" title="Urejanje izvorne kode razdelka: Kontraindikacije"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Zdravila, ki vsebujejo diklofenak, so kontraindicirana pri naslednjih stanjih: </p> <ul><li>preobčutljivost na diklofenak</li> <li>zgodovina alergijskih reakcij (<a href="/w/index.php?title=Bronhospazem&action=edit&redlink=1" class="new" title="Bronhospazem (stran ne obstaja)">bronhospazem</a>, <a href="/wiki/%C5%A0ok" title="Šok">šok</a>, <a href="/w/index.php?title=Rinitis&action=edit&redlink=1" class="new" title="Rinitis (stran ne obstaja)">rinitis</a>, <a href="/wiki/Koprivnica" class="mw-disambig" title="Koprivnica">koprivnica</a>) po uporabi <a href="/wiki/Aspirin" class="mw-redirect" title="Aspirin">aspirina</a> ali drugih nesteroidnih protivnetnih zdravil</li> <li><a href="/wiki/Nose%C4%8Dnost" title="Nosečnost">nosečnost</a> v tretjem trimesečju</li> <li>aktivna razjeda <a href="/wiki/%C5%BDelodec" title="Želodec">želodca</a> ali <a href="/wiki/Dvanajstnik" title="Dvanajstnik">dvanajstnika</a> in krvavitev iz prebavil</li> <li>vnetne črevesne bolezni, kot so <a href="/wiki/Crohnova_bolezen" title="Crohnova bolezen">Crohnova bolezen</a> in <a href="/wiki/Ulcerozni_kolitis" title="Ulcerozni kolitis">ulcerozni kolitis</a></li> <li>huda <a href="/w/index.php?title=Insuficienca_srca&action=edit&redlink=1" class="new" title="Insuficienca srca (stran ne obstaja)">insuficienca srca</a></li> <li>obvladovanje bolečine po premostitveni operaciji koronarnih arterij</li> <li>huda jetrna okvara</li> <li>huda okvara ledvic (<a href="/w/index.php?title=Kreatininski_o%C4%8Distek&action=edit&redlink=1" class="new" title="Kreatininski očistek (stran ne obstaja)">kreatininski očistek</a> < 30 ml/min)</li></ul> <p>Potrebna je previdnost pri bolnikih z že obstoječo <a href="/wiki/Porfirija" title="Porfirija">porfirijo</a>, ker lahko diklofenak bolezen poslabša, ter pri bolnikih s hudo, aktivno <a href="/wiki/Krvavitev" title="Krvavitev">krvavitvijo</a>, kot je na primer možganska krvavitev. Nesteroidnih protivnetnih zdravil se je treba izogibati med <a href="/wiki/Mrzlica_denga" title="Mrzlica denga">mrzlico denga</a>, saj pogosto privedejo do popuščanja <a href="/wiki/Kapilara" title="Kapilara">kapilar</a> in kasnejše odpovedi <a href="/wiki/Srce" title="Srce">srca</a>. </p> <div class="mw-heading mw-heading2"><h2 id="Neželeni_učinki"><span id="Ne.C5.BEeleni_u.C4.8Dinki"></span>Neželeni učinki</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=4" title="Uredi razdelek: Neželeni učinki" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=4" title="Urejanje izvorne kode razdelka: Neželeni učinki"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Diklofenak sodi med klasične nesteroidne protivnetne učinkovine, kamor spadajo tudi na primer <a href="/w/index.php?title=Etodalak&action=edit&redlink=1" class="new" title="Etodalak (stran ne obstaja)">etodalak</a>, <a href="/wiki/Naproksen" title="Naproksen">naproksen</a>, <a href="/wiki/Ibuprofen" title="Ibuprofen">ibuprofen</a>, <a href="/wiki/Ketoprofen" title="Ketoprofen">ketoprofen</a>). Gre za neselektivne zaviralce encima <a href="/wiki/Ciklooksigenaza" title="Ciklooksigenaza">ciklooksigenaza</a> (COX) in torej zavirajo obe izoobliki encima, COX-1 in COX-2. Njihovi stranski učinki so povezani z zavoro sinteze <a href="/wiki/Prostaglandin" title="Prostaglandin">prostaglandinov</a>. Pri njihovi uporabi so opisali številne neželene učinke. Med najbolj znanimi so gastrointestinalni učinki, v praksi manj prepoznani na dvig <a href="/wiki/Krvni_tlak" title="Krvni tlak">krvnega tlaka</a> in poslabšanje <a href="/wiki/Sr%C4%8Dno_popu%C5%A1%C4%8Danje" title="Srčno popuščanje">srčnega popuščanja</a>. Izkazujejo tudi neželene učinke na <a href="/wiki/Ledvice" class="mw-redirect" title="Ledvice">ledvice</a>.<sup id="cite_ref-Ravnikar_7-1" class="reference"><a href="#cite_note-Ravnikar-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Diklofenak je eno izmed nesteroidnih protivnetnih zdravil, ki jih bolniki prenašajo. Čeprav 20 % bolnikov dolgoročno občuti stranske učinke, le 2 % ljudi prenehata jemati zdravilo, predvsem zaradi prebavnih težav.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedija:Navajanje_virov" title="Wikipedija:Navajanje virov"><span title="Ta trditev potrebuje sklice na zanesljive vire. (mesec ni naveden )">navedi vir</span></a></i>]</sup> </p> <div class="mw-heading mw-heading3"><h3 id="Neželeni_učinki_na_srce"><span id="Ne.C5.BEeleni_u.C4.8Dinki_na_srce"></span>Neželeni učinki na srce</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=5" title="Uredi razdelek: Neželeni učinki na srce" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=5" title="Urejanje izvorne kode razdelka: Neželeni učinki na srce"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Po ugotovljenem zvečanem tveganjem za srčne napade pri uporabi selektivnega <a href="/wiki/Koksib" title="Koksib">zaviralca COX-2</a> <a href="/w/index.php?title=Rofekoksib&action=edit&redlink=1" class="new" title="Rofekoksib (stran ne obstaja)">rofekoksiba</a> leta 2004 se je pozornost preusmerila na vsa ostala nesteroidna protivnetna zdravila, vključno z diklofenakom. Rezultati raziskav so mešani, metaanaliza dokumentov in poročil do aprila 2006 kaže relativno večjo stopnjo bolezni srca (1,63 v primerjavi z neuporabniki).<sup id="cite_ref-BMJ2006-Kearney_10-0" class="reference"><a href="#cite_note-BMJ2006-Kearney-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Profesor Peter Weissberg, strokovni direktor Britanskega sklada za srce (British Heart Foundation), je dejal: »Povečanje tveganja za bolezni srca je majhno in veliko bolnikov s kronično bolečino meni, da lajšanje njihovih simptomov upravičuje majhno povečanje tveganja«. Le pri aspirinu je bilo ugotovljeno, da ne zvišuje tveganja za bolezni srca, vendar pa prinaša aspirin v primerjavi z diklofenakom višje tveganje za razjede na želodcu. </p><p>Kasnejša obširna študija 74.838 uporabnikov nesteroidnih protivnetnih zdravil ali koksibov ni razkrila nobenega dodatnega srčno-žilnega tveganja zaradi uporabe diklofenaka.<sup id="cite_ref-ArthritisRheum2006-Solomon_11-0" class="reference"><a href="#cite_note-ArthritisRheum2006-Solomon-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> Še obširnejša študija 1.028.437 danskih uporabnikov različnih nesteroidnih protivnetnih zdravil pa je razkrila, da je uporaba neselektivnega nesteroidnega protivnetnega zdravila diklofenak in selektivnega inhibitorja ciklooksigenaze-2 rofekoksiba povezana s povečanim tveganjem za smrt zaradi srčno-žilnih obolenj, ki je odvisno od odmerka.<sup id="cite_ref-pmid20530789_12-0" class="reference"><a href="#cite_note-pmid20530789-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> Britanska regulatorna agencija za zdravila in zdravstvene pripomočke (MHRA) je junija 2013 odločila, da zdravila ne smejo uporabljati bolniki z resnimi osnovnimi srčnimi boleznimi; za bolnike s srčnim popuščanjem, boleznimi srca tiste, ki so utrpeli možgansko kap je MHRA objavila priporočilo, da zdravilo popolnoma prenehajo uporabljati.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> Diklofenak ima podobno COX-2 selektivnost kot celekoksib.<sup id="cite_ref-pmid11496855_14-0" class="reference"><a href="#cite_note-pmid11496855-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> Analiza, ki jo je opravil medicinski strokovnjak <a href="/w/index.php?title=Ameri%C5%A1ki_urad_za_prehrano_in_zdravila&action=edit&redlink=1" class="new" title="Ameriški urad za prehrano in zdravila (stran ne obstaja)">Ameriškega urada za prehrano in zdravila</a> David Graham, je potrdila, da diklofenak zveča tveganje za <a href="/wiki/Miokardni_infarkt" title="Miokardni infarkt">miokardni infarkt</a> (srčno kap).<sup id="cite_ref-pmid16968830_15-0" class="reference"><a href="#cite_note-pmid16968830-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Gastrointestinalni_neželeni_učinki"><span id="Gastrointestinalni_ne.C5.BEeleni_u.C4.8Dinki"></span>Gastrointestinalni neželeni učinki</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=6" title="Uredi razdelek: Gastrointestinalni neželeni učinki" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=6" title="Urejanje izvorne kode razdelka: Gastrointestinalni neželeni učinki"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Prebavne motnje se najpogostejši neželeni učinek diklofenaka. Nastanek razjed ali krvavitev zahteva takojšnjo prekinitev zdravljenja z diklofenakom. Večina bolnikov med dolgotrajnim zdravljenjem prejme zdravilo za zaščitno prebavil, na primer <a href="/w/index.php?title=Misoprostol&action=edit&redlink=1" class="new" title="Misoprostol (stran ne obstaja)">misoprostol</a>, <a href="/wiki/Ranitidin" title="Ranitidin">ranitidin</a> ali <a href="/wiki/Omeprazol" title="Omeprazol">omeprazol</a>. </p> <div class="mw-heading mw-heading3"><h3 id="Jetrni_neželeni_učinki"><span id="Jetrni_ne.C5.BEeleni_u.C4.8Dinki"></span>Jetrni neželeni učinki</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=7" title="Uredi razdelek: Jetrni neželeni učinki" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=7" title="Urejanje izvorne kode razdelka: Jetrni neželeni učinki"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Poškodbe jeter so redke in večinoma reverzibilne. <a href="/wiki/Hepatitis" title="Hepatitis">Hepatitis</a> se pojavi redko, brez opozorilnih znakov in je lahko usoden. Bolniki z osteoartritisom razvijejo simptomatsko bolezen jeter pogosteje kot bolnikih z revmatoidnim artritisom. Med dolgotrajnim zdravljenjem je treba redno spremljati jetrno funkcijo. Pri kratkotrajnem zdravljenju bolečine ali vročine pa diklofenak ni bolj hepatotoksičen kot druga nesteroidna protivnetna zdravila. Decembra 2009 so Endo, Novartis in Ameriški urad za prehrano in zdravila (FDA) obvestili zdravstvene delavce, da je zdravilu treba dodati nova opozorila in previdnostne ukrepe zaradi možnosti povišanja vrednosti pri izvidih jetrnih testov med zdravljenjem z vsemi zdravili, ki vsebujejo diklofenak v obliki natrijeve soli.<sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup>O primerih hepatotoksičnosti zaradi diklofenaka so poročali v prvem mesecu uporabe zdravila, vendar pa se lahko pojavijo kadarkoli med zdravljenjem. V raziskavah po utrženju zdravila so poročali o primerih hudih jetrnih reakcij, vključno z <a href="/wiki/Nekroza" title="Nekroza">nekrozo</a> jeter, <a href="/wiki/Zlatenica" title="Zlatenica">zlatenico</a>, hepatitisom z ali brez zlatenice ter odpovedjo jeter. Nekaterih od teh primerov so privedli do smrti ali presaditve jeter. Pri dolgotrajnih bolnikih je potrebno občasno merjenje vrednosti <a href="/w/index.php?title=Transaminaza&action=edit&redlink=1" class="new" title="Transaminaza (stran ne obstaja)">transaminaz</a>. Na osnovi podatkov kliničnih preskušanj in raziskav po utrženju je treba transaminaze začeti spremljati 4 do 8 tednov po začetku zdravljenja z diklofenakom. </p> <div class="mw-heading mw-heading3"><h3 id="Ledvični_neželeni_učinki"><span id="Ledvi.C4.8Dni_ne.C5.BEeleni_u.C4.8Dinki"></span>Ledvični neželeni učinki</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=8" title="Uredi razdelek: Ledvični neželeni učinki" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=8" title="Urejanje izvorne kode razdelka: Ledvični neželeni učinki"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Študija, narejena v Pakistanu, je pokazala, da diklofenak povzroča <a href="/wiki/Akutna_odpoved_ledvic" class="mw-redirect" title="Akutna odpoved ledvic">akutno odpoved ledvic</a> pri jastrebih, ki so bili hranjeni s trupli živali, ki so bile pred kratkim zdravljene z diklofenakom. Predvideva se, da vrste, občutljive na zdravilo, in določeni ljudje nimajo genov za tvorjenje specifičnih razstrupljevalnih encimov. </p><p>Neželeni učinki na ledvice so povezani z zaviranjem encima COX, vendar se tem neželenim učinkom ne da izogniti z uporabo selektivnih zaviralcev COX-2. V ledvicah se namreč normalno izražata obe izobliki encima, COX-1 in COX-2.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> Neželeni učinki na ledvice se kažejo z naslednjimi kliničnimi sindromi, ki se med seboj razlikujejo po času uživanja zdravila, ki je potreben za razvoj okvare, po patogenezi in načinu zdravljenja: akutno <a href="/w/index.php?title=Hemodinamska_led%C2%ADvi%C4%8Dna_odpoved&action=edit&redlink=1" class="new" title="Hemodinamska ledvična odpoved (stran ne obstaja)">hemodinamsko ledvično odpovedjo</a>, akutnim <a href="/w/index.php?title=Tubulointersticijski_nefritis&action=edit&redlink=1" class="new" title="Tubulointersticijski nefritis (stran ne obstaja)">tubulointersticijskim nefritisom</a> z <a href="/w/index.php?title=Nefroti%C4%8Dni_sindrom&action=edit&redlink=1" class="new" title="Nefrotični sindrom (stran ne obstaja)">nefrotičnim sindromom</a> ali <a href="/w/index.php?title=Kroni%C4%8Dna_ledvi%C4%8Dna_odpoved&action=edit&redlink=1" class="new" title="Kronična ledvična odpoved (stran ne obstaja)">kronično ledvično odpovedjo</a>.<sup id="cite_ref-Ravnikar_7-2" class="reference"><a href="#cite_note-Ravnikar-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Vplivi_na_duševno_zdravje"><span id="Vplivi_na_du.C5.A1evno_zdravje"></span>Vplivi na duševno zdravje</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=9" title="Uredi razdelek: Vplivi na duševno zdravje" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=9" title="Urejanje izvorne kode razdelka: Vplivi na duševno zdravje"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Simptomi na osrednje živčevje so redki, vendar se pojavljajo v dovolj velikem številu, da jih je treba uvrstiti med možne neželene učinke. Ti vključujejo <a href="/wiki/Depresija" class="mw-disambig" title="Depresija">depresijo</a>, <a href="/wiki/Tesnoba" title="Tesnoba">tesnobo</a>, razdražljivost, nočne more in psihotične reakcije.<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Drugi_neželeni_učinki"><span id="Drugi_ne.C5.BEeleni_u.C4.8Dinki"></span>Drugi neželeni učinki</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=10" title="Uredi razdelek: Drugi neželeni učinki" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=10" title="Urejanje izvorne kode razdelka: Drugi neželeni učinki"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Redko se pojavi zaviranje delovanja <a href="/wiki/Kostni_mozeg" title="Kostni mozeg">kostnega mozga</a> (<a href="/wiki/Levkopenija" title="Levkopenija">levkopenija</a>, <a href="/w/index.php?title=Agranulocitoza&action=edit&redlink=1" class="new" title="Agranulocitoza (stran ne obstaja)">agranulocitoza</a>, <a href="/w/index.php?title=Trombopenija&action=edit&redlink=1" class="new" title="Trombopenija (stran ne obstaja)">trombopenija</a> s <a href="/w/index.php?title=Purpura&action=edit&redlink=1" class="new" title="Purpura (stran ne obstaja)">purpuro</a> ali brez nje, <a href="/wiki/Aplasti%C4%8Dna_anemija" title="Aplastična anemija">aplastična anemija</a>). Te bolezni so lahko smrtno nevarne in če so odkrite prepozno, ireverzibilne. Vse bolnike je treba skrbno spremljati. Diklofenak lahko ovira normalen <a href="/wiki/Menstrualni_ciklus" class="mw-redirect" title="Menstrualni ciklus">menstrualni ciklus</a>. Raziskava, objavljena leta 2010, je povezala uporabo diklofenaka s povečanim tveganjem za možgansko kap.<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Sklici">Sklici</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Diklofenak&veaction=edit&section=11" title="Uredi razdelek: Sklici" class="mw-editsection-visualeditor"><span>uredi</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Diklofenak&action=edit&section=11" title="Urejanje izvorne kode razdelka: Sklici"><span>uredi kodo</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="reflist" style="list-style-type: decimal;"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.termania.net/slovarji/slovenski-medicinski-slovar/5512023/diklofenak?query=diklofenak">http://www.termania.net/slovarji/slovenski-medicinski-slovar/5512023/diklofenak?query=diklofenak</a>, Slovenski medicinski e-slovar, vpogled: 5. 4. 2014.</span> </li> <li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.cbz.si/cbz/bazazdr2.nsf/Search/$searchForm?SearchView">http://www.cbz.si/cbz/bazazdr2.nsf/Search/$searchForm?SearchView</a>, Centralna baza zdravil, vpogled: 5. 4. 2014.</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><a href="#cite_ref-3">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.novartis.com/about-novartis/company-history/index.shtml">http://www.novartis.com/about-novartis/company-history/index.shtml</a></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><a href="#cite_ref-4">↑</a></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r5980307">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"»""«""›""‹"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free a,.mw-parser-output .citation .cs1-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited a,.mw-parser-output .id-lock-registration a,.mw-parser-output .citation .cs1-lock-limited a,.mw-parser-output .citation .cs1-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription a,.mw-parser-output .citation .cs1-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:#d33}.mw-parser-output .cs1-visible-error{color:#d33}.mw-parser-output .cs1-maint{display:none;color:#3a3;margin-left:0.3em}.mw-parser-output .cs1-format{font-size:95%}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://archive.today/20130801120559/http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1434053">»arhivska kopija«</a>. 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Pridobljeno 3. aprila 2011</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=neznano&rft.jtitle=The+American+Society+of+Health-System+Pharmacists&rft.atitle=Diclofenac+Epolamine&rft_id=http%3A%2F%2Fwww.drugs.com%2Fmonograph%2Fdiclofenac-epolamine.html&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><a href="#cite_ref-9">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.mayoclinic.com/health/drug-information/DR600545">http://www.mayoclinic.com/health/drug-information/DR600545</a></span> </li> <li id="cite_note-BMJ2006-Kearney-10"><span class="mw-cite-backlink"><a href="#cite_ref-BMJ2006-Kearney_10-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFKearney_P.Baigent_C.Godwin_J.H.Emberson_J.2006" class="citation journal cs1">Kearney P.; Baigent C.; Godwin J.H.; Emberson J.; Patrono C. 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Meta-analysis of randomised trials«</a>. <i>BMJ</i>. <b>332</b> (7553): 1302–8. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1136%2Fbmj.332.7553.1302">10.1136/bmj.332.7553.1302</a>. <a href="/wiki/PMC_(identifikator)" class="mw-redirect" title="PMC (identifikator)">PMC</a> <span class="cs1-lock-free" title="Prosto dostopno"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1473048">1473048</a></span>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16740558">16740558</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=BMJ&rft.atitle=Do+selective+cyclo-oxygenase-2+inhibitors+and+traditional+non-steroidal+anti-inflammatory+drugs+increase+the+risk+of+atherothrombosis%3F+Meta-analysis+of+randomised+trials&rft.volume=332&rft.issue=7553&rft.pages=1302-8&rft.date=2006&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1473048%23id-name%3DPMC&rft_id=info%3Apmid%2F16740558&rft_id=info%3Adoi%2F10.1136%2Fbmj.332.7553.1302&rft.au=Kearney+P.&rft.au=Baigent+C.&rft.au=Godwin+J.H.&rft.au=Emberson+J.&rft.au=Patrono+C.&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1473048&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-ArthritisRheum2006-Solomon-11"><span class="mw-cite-backlink"><a href="#cite_ref-ArthritisRheum2006-Solomon_11-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFSolomon_DAvorn_JStürmer_TGlynn_R2006" class="citation journal cs1">Solomon D; Avorn J; Stürmer T; Glynn R; Mogun H; Schneeweiss S (2006). »Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk«. <i>Arthritis Rheum</i>. <b>54</b> (5): 1378–89. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fart.21887">10.1002/art.21887</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16645966">16645966</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Arthritis+Rheum&rft.atitle=Cardiovascular+outcomes+in+new+users+of+coxibs+and+nonsteroidal+antiinflammatory+drugs%3A+high-risk+subgroups+and+time+course+of+risk&rft.volume=54&rft.issue=5&rft.pages=1378-89&rft.date=2006&rft_id=info%3Adoi%2F10.1002%2Fart.21887&rft_id=info%3Apmid%2F16645966&rft.au=Solomon+D&rft.au=Avorn+J&rft.au=St%C3%BCrmer+T&rft.au=Glynn+R&rft.au=Mogun+H&rft.au=Schneeweiss+S&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-pmid20530789-12"><span class="mw-cite-backlink"><a href="#cite_ref-pmid20530789_12-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFFosbøl_ELFolke_FJacobsen_SRasmussen_JN2010" class="citation journal cs1">Fosbøl EL; Folke F; Jacobsen S; Rasmussen JN; Sørensen R; in sod. (2010). »Cause-Specific Cardiovascular Risk Associated With Nonsteroidal Antiinflammatory Drugs Among Healthy Individuals«. <i>Circ Cardiovasc Qual Outcomes</i>. <b>3</b> (4): 395–405. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1161%2FCIRCOUTCOMES.109.861104">10.1161/CIRCOUTCOMES.109.861104</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20530789">20530789</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=Circ+Cardiovasc+Qual+Outcomes&rft.atitle=Cause-Specific+Cardiovascular+Risk+Associated+With+Nonsteroidal+Antiinflammatory+Drugs+Among+Healthy+Individuals&rft.volume=3&rft.issue=4&rft.pages=395-405&rft.date=2010&rft_id=info%3Adoi%2F10.1161%2FCIRCOUTCOMES.109.861104&rft_id=info%3Apmid%2F20530789&rft.au=Fosb%C3%B8l+EL&rft.au=Folke+F&rft.au=Jacobsen+S&rft.au=Rasmussen+JN&rft.au=S%C3%B8rensen+R&rft.au=Schramm+TK&rft.au=Andersen+SS&rft.au=Rasmussen+S&rft.au=Poulsen+HE&rft.au=K%C3%B8ber+L&rft.au=Torp-Pedersen+C&rft.au=Gislason+GH&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><a href="#cite_ref-13">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="https://www.bbc.co.uk/news/health-23109314">BBC: Heart risk warning over painkiller diclofenac, 29 June 2013</a></span> </li> <li id="cite_note-pmid11496855-14"><span class="mw-cite-backlink"><a href="#cite_ref-pmid11496855_14-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFFitzGerald_GPatrono_C2001" class="citation journal cs1">FitzGerald G; Patrono C (2001). »The coxibs, selective inhibitors of cyclooxygenase-2«. <i>N Engl J Med</i>. <b>345</b> (6): 433–42. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJM200108093450607">10.1056/NEJM200108093450607</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11496855">11496855</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=N+Engl+J+Med&rft.atitle=The+coxibs%2C+selective+inhibitors+of+cyclooxygenase-2&rft.volume=345&rft.issue=6&rft.pages=433-42&rft.date=2001&rft_id=info%3Adoi%2F10.1056%2FNEJM200108093450607&rft_id=info%3Apmid%2F11496855&rft.au=FitzGerald+G&rft.au=Patrono+C&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-pmid16968830-15"><span class="mw-cite-backlink"><a href="#cite_ref-pmid16968830_15-0">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite id="CITEREFGraham_D2006" class="citation journal cs1">Graham D (2006). <a rel="nofollow" class="external text" href="http://jama.ama-assn.org/cgi/content/full/296/13/1653">»COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense«</a>. <i>JAMA</i>. <b>296</b> (13): 1653–6. <a href="/wiki/Doi_(identifikator)" class="mw-redirect" title="Doi (identifikator)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjama.296.13.jed60058">10.1001/jama.296.13.jed60058</a>. <a href="/wiki/PMID_(identifikator)" class="mw-redirect" title="PMID (identifikator)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16968830">16968830</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=%C4%8Dlanek&rft.jtitle=JAMA&rft.atitle=COX-2+inhibitors%2C+other+NSAIDs%2C+and+cardiovascular+risk%3A+the+seduction+of+common+sense&rft.volume=296&rft.issue=13&rft.pages=1653-6&rft.date=2006&rft_id=info%3Adoi%2F10.1001%2Fjama.296.13.jed60058&rft_id=info%3Apmid%2F16968830&rft.au=Graham+D&rft_id=http%3A%2F%2Fjama.ama-assn.org%2Fcgi%2Fcontent%2Ffull%2F296%2F13%2F1653&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><a href="#cite_ref-16">↑</a></span> <span class="reference-text"><a rel="nofollow" class="external free" href="http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm193047.htm">http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm193047.htm</a></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><a href="#cite_ref-17">↑</a></span> <span class="reference-text">Brater DC (2002). "Renal effects of cyclooxygyenase-2-selective inhibitors". J Pain Symptom Manage 23 (4 Suppl): S15–20; discussion S21–3.</span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><a href="#cite_ref-18">↑</a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r5980307"><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/sfx/diclofenac-side-effects.html">»Diclofenac Side Effects«</a>. <i>Drugs.com</i><span class="reference-accessdate">. Pridobljeno 21. januarja 2013</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=neznano&rft.jtitle=Drugs.com&rft.atitle=Diclofenac+Side+Effects&rft_id=http%3A%2F%2Fwww.drugs.com%2Fsfx%2Fdiclofenac-side-effects.html&rfr_id=info%3Asid%2Fsl.wikipedia.org%3ADiklofenak" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><a href="#cite_ref-19">↑</a></span> <span class="reference-text">ABC News: Study links Voltaren to strokes <a rel="nofollow" class="external free" href="http://www.abc.net.au/news/stories/2010/09/14/3011102.htm">http://www.abc.net.au/news/stories/2010/09/14/3011102.htm</a></span> </li> </ol></div></div> <div role="navigation" class="navbox" aria-label="Navbox" style="padding:3px"><table class="nowraplinks hlist navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Wikipedija:Normativna_kontrola" title="Wikipedija:Normativna kontrola">Normativna kontrola: Narodne knjižnice</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q244408#identifiers" title="Uredite to na Wikipodatkih"><img alt="Uredite to na Wikipodatkih" src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></th><td class="navbox-list navbox-odd" style="text-align:left;border-left-width:2px;border-left-style:solid;width:100%;padding:0px"><div style="padding:0em 0.25em"> <ul><li><span class="uid"><a rel="nofollow" class="external text" href="https://d-nb.info/gnd/4239268-8">Nemčija</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="http://uli.nli.org.il/F/?func=find-b&local_base=NLX10&find_code=UID&request=987007552914605171">Izrael</a></span></li> <li><span class="uid"><a rel="nofollow" class="external text" href="https://id.loc.gov/authorities/subjects/sh85037684">ZDA</a></span></li></ul> </div></td></tr></tbody></table></div>    </div><noscript><img src="https://login.wikimedia.org/wiki/Special:CentralAutoLogin/start?type=1x1&useformat=desktop" alt="" width="1" height="1" style="border: none; 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