CINXE.COM

<!DOCTYPE html> <html lang="en" xmlns:fb="http://www.facebook.com/2008/fbml" class="wf-loading"> <head prefix="og: https://ogp.me/ns# fb: https://ogp.me/ns/fb# academia: https://ogp.me/ns/fb/academia#"> <meta charset="utf-8"> <meta name=viewport content="width=device-width, initial-scale=1"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <title>Angela Bustamante - Academia.edu</title>  <link href="//a.academia-assets.com/images/favicons/favicon-production.ico" rel="shortcut icon" type="image/vnd.microsoft.icon"> <link rel="apple-touch-icon" sizes="57x57" href="//a.academia-assets.com/images/favicons/apple-touch-icon-57x57.png"> <link rel="apple-touch-icon" sizes="60x60" href="//a.academia-assets.com/images/favicons/apple-touch-icon-60x60.png"> <link rel="apple-touch-icon" sizes="72x72" href="//a.academia-assets.com/images/favicons/apple-touch-icon-72x72.png"> <link rel="apple-touch-icon" sizes="76x76" href="//a.academia-assets.com/images/favicons/apple-touch-icon-76x76.png"> <link rel="apple-touch-icon" sizes="114x114" href="//a.academia-assets.com/images/favicons/apple-touch-icon-114x114.png"> <link rel="apple-touch-icon" sizes="120x120" href="//a.academia-assets.com/images/favicons/apple-touch-icon-120x120.png"> <link rel="apple-touch-icon" sizes="144x144" href="//a.academia-assets.com/images/favicons/apple-touch-icon-144x144.png"> <link rel="apple-touch-icon" sizes="152x152" href="//a.academia-assets.com/images/favicons/apple-touch-icon-152x152.png"> <link rel="apple-touch-icon" sizes="180x180" href="//a.academia-assets.com/images/favicons/apple-touch-icon-180x180.png"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-32x32.png" sizes="32x32"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-194x194.png" sizes="194x194"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-96x96.png" sizes="96x96"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/android-chrome-192x192.png" sizes="192x192"> <link rel="icon" type="image/png" href="//a.academia-assets.com/images/favicons/favicon-16x16.png" sizes="16x16"> <link rel="manifest" href="//a.academia-assets.com/images/favicons/manifest.json"> <meta name="msapplication-TileColor" content="#2b5797"> <meta name="msapplication-TileImage" content="//a.academia-assets.com/images/favicons/mstile-144x144.png"> <meta name="theme-color" content="#ffffff"> <script> window.performance && window.performance.measure && window.performance.measure("Time To First Byte", "requestStart", "responseStart"); </script> <script> (function() { if (!window.URLSearchParams || !window.history || !window.history.replaceState) { return; } var searchParams = new URLSearchParams(window.location.search); var paramsToDelete = [ 'fs', 'sm', 'swp', 'iid', 'nbs', 'rcc', // related content category 'rcpos', // related content carousel position 'rcpg', // related carousel page 'rchid', // related content hit id 'f_ri', // research interest id, for SEO tracking 'f_fri', // featured research interest, for SEO tracking (param key without value) 'f_rid', // from research interest directory for SEO tracking 'f_loswp', // from research interest pills on LOSWP sidebar for SEO tracking 'rhid', // referrring hit id ]; if (paramsToDelete.every((key) => searchParams.get(key) === null)) { return; } paramsToDelete.forEach((key) => { searchParams.delete(key); }); var cleanUrl = new URL(window.location.href); cleanUrl.search = searchParams.toString(); history.replaceState({}, document.title, cleanUrl); })(); </script> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "profiles/works", 'action': "summary", 'controller_action': 'profiles/works#summary', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script type="text/javascript"> window.sendUserTiming = function(timingName) { if (!(window.performance && window.performance.measure)) return; var entries = window.performance.getEntriesByName(timingName, "measure"); if (entries.length !== 1) return; var timingValue = Math.round(entries[0].duration); gtag('event', 'timing_complete', { name: timingName, value: timingValue, event_category: 'User-centric', }); }; window.sendUserTiming("Time To First Byte"); </script> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Hdoxv8XQ+ytz9ekK1okbdhdw2FfWoS4NgJ5IcmGijdx2a267g+dmbaHonQ4lop3lR9ZPv+tR5p6X9VAjEUNrog==" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/wow-77f7b87cb1583fc59aa8f94756ebfe913345937eb932042b4077563bebb5fb4b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/social/home-9e8218e1301001388038e3fc3427ed00d079a4760ff7745d1ec1b2d59103170a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-10fa40af19d25203774df2d4a03b9b5771b45109c2304968038e88a81d1215c5.css" /> <meta name="author" content="angela bustamante" /> <meta name="description" content="Angela Bustamante: 1 Follower, 1 Following, 18 Research papers. Research interests: Neurochemistry, Vascular dementia, and Functional Connectivity." /> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs" /> <script> var $controller_name = 'works'; var $action_name = "summary"; var $rails_env = 'production'; var $app_rev = '92477ec68c09d28ae4730a4143c926f074776319'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.Aedu = { hit_data: null }; window.Aedu.SiteStats = {"premium_universities_count":15276,"monthly_visitors":"113 million","monthly_visitor_count":113784677,"monthly_visitor_count_in_millions":113,"user_count":277516170,"paper_count":55203019,"paper_count_in_millions":55,"page_count":432000000,"page_count_in_millions":432,"pdf_count":16500000,"pdf_count_in_millions":16}; window.Aedu.serverRenderTime = new Date(1732777002000); window.Aedu.timeDifference = new Date().getTime() - 1732777002000; window.Aedu.isUsingCssV1 = false; window.Aedu.enableLocalization = true; window.Aedu.activateFullstory = false; window.Aedu.serviceAvailability = { status: {"attention_db":"on","bibliography_db":"on","contacts_db":"on","email_db":"on","indexability_db":"on","mentions_db":"on","news_db":"on","notifications_db":"on","offsite_mentions_db":"on","redshift":"on","redshift_exports_db":"on","related_works_db":"on","ring_db":"on","user_tests_db":"on"}, serviceEnabled: function(service) { return this.status[service] === "on"; }, readEnabled: function(service) { return this.serviceEnabled(service) || this.status[service] === "read_only"; }, }; window.Aedu.viewApmTrace = function() { // Check if x-apm-trace-id meta tag is set, and open the trace in APM // in a new window if it is. var apmTraceId = document.head.querySelector('meta[name="x-apm-trace-id"]'); if (apmTraceId) { var traceId = apmTraceId.content; // Use trace ID to construct URL, an example URL looks like: // https://app.datadoghq.com/apm/traces?query=trace_id%31298410148923562634 var apmUrl = 'https://app.datadoghq.com/apm/traces?query=trace_id%3A' + traceId; window.open(apmUrl, '_blank'); } }; </script>  <link href="https://fonts.googleapis.com/css?family=Roboto:100,100i,300,300i,400,400i,500,500i,700,700i,900,900i" rel="stylesheet"> <link href="//maxcdn.bootstrapcdn.com/font-awesome/4.3.0/css/font-awesome.min.css" rel="stylesheet"> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/libraries-a9675dcb01ec4ef6aa807ba772c7a5a00c1820d3ff661c1038a20f80d06bb4e4.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/academia-bdb9e8c097f01e611f2fc5e2f1a9dc599beede975e2ae5629983543a1726e947.css" /> <link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system_legacy-056a9113b9a0f5343d013b29ee1929d5a18be35fdcdceb616600b4db8bd20054.css" /> <script src="//a.academia-assets.com/assets/webpack_bundles/runtime-bundle-005434038af4252ca37c527588411a3d6a0eabb5f727fac83f8bbe7fd88d93bb.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/webpack_libraries_and_infrequently_changed.wjs-bundle-bae13f9b51961d5f1e06008e39e31d0138cb31332e8c2e874c6d6a250ec2bb14.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/core_webpack.wjs-bundle-19a25d160d01bde427443d06cd6b810c4c92c6026e7cb31519e06313eb24ed90.js"></script> <script src="//a.academia-assets.com/assets/webpack_bundles/sentry.wjs-bundle-5fe03fddca915c8ba0f7edbe64c194308e8ce5abaed7bffe1255ff37549c4808.js"></script> <script> jade = window.jade || {}; jade.helpers = window.$h; jade._ = window._; </script>  <script id="tag-manager-head-root">(function(w,d,s,l,i){w[l]=w[l]||[];w[l].push({'gtm.start': new Date().getTime(),event:'gtm.js'});var f=d.getElementsByTagName(s)[0], j=d.createElement(s),dl=l!='dataLayer'?'&l='+l:'';j.async=true;j.src= 'https://www.googletagmanager.com/gtm.js?id='+i+dl;f.parentNode.insertBefore(j,f); })(window,document,'script','dataLayer_old','GTM-5G9JF7Z');</script>  <script> window.gptadslots = []; window.googletag = window.googletag || {}; window.googletag.cmd = window.googletag.cmd || []; </script> <script type="text/javascript"> // TODO(jacob): This should be defined, may be rare load order problem. // Checking if null is just a quick fix, will default to en if unset. // Better fix is to run this immedietely after I18n is set. if (window.I18n != null) { I18n.defaultLocale = "en"; I18n.locale = "en"; I18n.fallbacks = true; } </script> <link rel="canonical" href="https://independent.academia.edu/AngelaBustamante2" /> </head>   <body class='c-profiles/works a-summary logged_out'>  <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script><script>window.fbAsyncLoad = function() { // Protection against double calling of this function if (window.FB) { return; } (function(d, s, id){ var js, fjs = d.getElementsByTagName(s)[0]; if (d.getElementById(id)) {return;} js = d.createElement(s); js.id = id; js.src = "//connect.facebook.net/en_US/sdk.js"; fjs.parentNode.insertBefore(js, fjs); }(document, 'script', 'facebook-jssdk')); } if (!window.defer_facebook) { // Autoload if not deferred window.fbAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.fbAsyncLoad(); }, 5000); }</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script><script>window.googleAsyncLoad = function() { // Protection against double calling of this function (function(d) { var js; var id = 'google-jssdk'; var ref = d.getElementsByTagName('script')[0]; if (d.getElementById(id)) { return; } js = d.createElement('script'); js.id = id; js.async = true; js.onload = loadGoogle; js.src = "https://accounts.google.com/gsi/client" ref.parentNode.insertBefore(js, ref); }(document)); } if (!window.defer_google) { // Autoload if not deferred window.googleAsyncLoad(); } else { // Defer loading by 5 seconds setTimeout(function() { window.googleAsyncLoad(); }, 5000); }</script> <div id="tag-manager-body-root">  <noscript><iframe src="https://www.googletagmanager.com/ns.html?id=GTM-5G9JF7Z" height="0" width="0" style="display:none;visibility:hidden"></iframe></noscript>   <script> window.addEventListener('load', function() { if (document.querySelector('input[name="commit"]')) { document.querySelector('input[name="commit"]').addEventListener('click', function() { gtag('event', 'click', { event_category: 'button', event_label: 'Log In' }) }) } }); </script> </div> <script>var _comscore = _comscore || []; _comscore.push({ c1: "2", c2: "26766707" }); (function() { var s = document.createElement("script"), el = document.getElementsByTagName("script")[0]; s.async = true; s.src = (document.location.protocol == "https:" ? "https://sb" : "http://b") + ".scorecardresearch.com/beacon.js"; el.parentNode.insertBefore(s, el); })();</script><img src="https://sb.scorecardresearch.com/p?c1=2&c2=26766707&cv=2.0&cj=1" style="position: absolute; visibility: hidden" /> <div id='react-modal'></div> <div class='DesignSystem'> <a class='u-showOnFocus' href='#site'> Skip to main content </a> </div> <div id="upgrade_ie_banner" style="display: none;"><p>Academia.edu no longer supports Internet Explorer.</p><p>To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.getElementById('upgrade_ie_banner').style.display = 'block'; }</script> <div class="DesignSystem bootstrap ShrinkableNav"><div class="navbar navbar-default main-header"><div class="container-wrapper" id="main-header-container"><div class="container"><div class="navbar-header"><div class="nav-left-wrapper u-mt0x"><div class="nav-logo"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="visible-xs-inline-block" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hidden-xs" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a></div><div class="nav-search"><div class="SiteSearch-wrapper select2-no-default-pills"><form class="js-SiteSearch-form DesignSystem" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><i class="SiteSearch-icon fa fa-search u-fw700 u-positionAbsolute u-tcGrayDark"></i><input class="js-SiteSearch-form-input SiteSearch-form-input form-control" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" value="" /></form></div></div></div><div class="nav-right-wrapper pull-right"><ul class="NavLinks js-main-nav list-unstyled"><li class="NavLinks-link"><a class="js-header-login-url Button Button--inverseGray Button--sm u-mb4x" id="nav_log_in" rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="NavLinks-link u-p0x"><a class="Button Button--inverseGray Button--sm u-mb4x" rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li></ul><button class="hidden-lg hidden-md hidden-sm u-ml4x navbar-toggle collapsed" data-target=".js-mobile-header-links" data-toggle="collapse" type="button"><span class="icon-bar"></span><span class="icon-bar"></span><span class="icon-bar"></span></button></div></div><div class="collapse navbar-collapse js-mobile-header-links"><ul class="nav navbar-nav"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/login">Log In</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/signup">Sign Up</a></li><li class="u-borderColorGrayLight u-borderBottom1 js-mobile-nav-expand-trigger"><a href="#">more&nbsp<span class="caret"></span></a></li><li><ul class="js-mobile-nav-expand-section nav navbar-nav u-m0x collapse"><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/about">About</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/press">Press</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://medium.com/@academia">Blog</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="false" href="https://www.academia.edu/documents">Papers</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://www.academia.edu/hiring"><i class="fa fa-briefcase"></i> We're Hiring!</a></li><li class="u-borderColorGrayLight u-borderBottom1"><a rel="nofollow" href="https://support.academia.edu/"><i class="fa fa-question-circle"></i> Help Center</a></li><li class="js-mobile-nav-collapse-trigger u-borderColorGrayLight u-borderBottom1 dropup" style="display:none"><a href="#">less&nbsp<span class="caret"></span></a></li></ul></li></ul></div></div></div><script>(function(){ var $moreLink = $(".js-mobile-nav-expand-trigger"); var $lessLink = $(".js-mobile-nav-collapse-trigger"); var $section = $('.js-mobile-nav-expand-section'); $moreLink.click(function(ev){ ev.preventDefault(); $moreLink.hide(); $lessLink.show(); $section.collapse('show'); }); $lessLink.click(function(ev){ ev.preventDefault(); $moreLink.show(); $lessLink.hide(); $section.collapse('hide'); }); })() if ($a.is_logged_in() || false) { new Aedu.NavigationController({ el: '.js-main-nav', showHighlightedNotification: false }); } else { $(".js-header-login-url").attr("href", $a.loginUrlWithRedirect()); } Aedu.autocompleteSearch = new AutocompleteSearch({el: '.js-SiteSearch-form'});</script></div></div> <div id='site' class='fixed'> <div id="content" class="clearfix"> <script>document.addEventListener('DOMContentLoaded', function(){ var $dismissible = $(".dismissible_banner"); $dismissible.click(function(ev) { $dismissible.hide(); }); });</script> <script src="//a.academia-assets.com/assets/webpack_bundles/profile.wjs-bundle-e032f1d55548c2f2dee4eac9fe52f38beaf13471f2298bb2ea82725ae930b83c.js" defer="defer"></script><script>Aedu.rankings = { showPaperRankingsLink: false } $viewedUser = Aedu.User.set_viewed( {"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2","photo":"/images/s65_no_pic.png","has_photo":false,"is_analytics_public":false,"interests":[{"id":8745,"name":"Neurochemistry","url":"https://www.academia.edu/Documents/in/Neurochemistry"},{"id":97766,"name":"Vascular dementia","url":"https://www.academia.edu/Documents/in/Vascular_dementia"},{"id":52763,"name":"Functional Connectivity","url":"https://www.academia.edu/Documents/in/Functional_Connectivity"},{"id":43367,"name":"Movement disorders","url":"https://www.academia.edu/Documents/in/Movement_disorders"},{"id":84745,"name":"Movement","url":"https://www.academia.edu/Documents/in/Movement"}]} ); if ($a.is_logged_in() && $viewedUser.is_current_user()) { $('body').addClass('profile-viewed-by-owner'); } $socialProfiles = []</script><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/AngelaBustamante2","location":"/AngelaBustamante2","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/AngelaBustamante2","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="ProfileCheckPaperUpdate" data-props="{}" data-trace="false" data-dom-id="ProfileCheckPaperUpdate-react-component-e6a6320d-b1d4-46fc-b8df-b590c0323eeb"></div> <div id="ProfileCheckPaperUpdate-react-component-e6a6320d-b1d4-46fc-b8df-b590c0323eeb"></div> <div class="DesignSystem"><div class="onsite-ping" id="onsite-ping"></div></div><div class="profile-user-info DesignSystem"><div class="social-profile-container"><div class="left-panel-container"><div class="user-info-component-wrapper"><div class="user-summary-cta-container"><div class="user-summary-container"><div class="social-profile-avatar-container"><img class="profile-avatar u-positionAbsolute" border="0" alt="" src="//a.academia-assets.com/images/s200_no_pic.png" /></div><div class="title-container"><h1 class="ds2-5-heading-sans-serif-sm">Angela Bustamante</h1><div class="affiliations-container fake-truncate js-profile-affiliations"></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Angela" data-follow-user-id="44194127" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="44194127"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Follower</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">1</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-author</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44194127" href="https://www.academia.edu/Documents/in/Neurochemistry"><div id="js-react-on-rails-context" style="display:none" data-rails-context="{"inMailer":false,"i18nLocale":"en","i18nDefaultLocale":"en","href":"https://independent.academia.edu/AngelaBustamante2","location":"/AngelaBustamante2","scheme":"https","host":"independent.academia.edu","port":null,"pathname":"/AngelaBustamante2","search":null,"httpAcceptLanguage":null,"serverSide":false}"></div> <div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Neurochemistry"]}" data-trace="false" data-dom-id="Pill-react-component-216cce76-918c-4110-8296-16a3e42e33f4"></div> <div id="Pill-react-component-216cce76-918c-4110-8296-16a3e42e33f4"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44194127" href="https://www.academia.edu/Documents/in/Vascular_dementia"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Vascular dementia"]}" data-trace="false" data-dom-id="Pill-react-component-f241ed3c-f0f6-44ee-aae8-15eecb2d39cc"></div> <div id="Pill-react-component-f241ed3c-f0f6-44ee-aae8-15eecb2d39cc"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44194127" href="https://www.academia.edu/Documents/in/Functional_Connectivity"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Functional Connectivity"]}" data-trace="false" data-dom-id="Pill-react-component-61180bd8-51c1-481c-a1fb-fa691299e52e"></div> <div id="Pill-react-component-61180bd8-51c1-481c-a1fb-fa691299e52e"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44194127" href="https://www.academia.edu/Documents/in/Movement_disorders"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Movement disorders"]}" data-trace="false" data-dom-id="Pill-react-component-fa25076a-7c79-4b65-9601-d90452f143cf"></div> <div id="Pill-react-component-fa25076a-7c79-4b65-9601-d90452f143cf"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="44194127" href="https://www.academia.edu/Documents/in/Movement"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Movement"]}" data-trace="false" data-dom-id="Pill-react-component-eafd3160-3638-4717-8b8d-1b04f9f4b89a"></div> <div id="Pill-react-component-eafd3160-3638-4717-8b8d-1b04f9f4b89a"></div> </a></div></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Angela Bustamante</h3></div><div class="js-work-strip profile--work_container" data-work-id="53155562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming"><img alt="Research paper thumbnail of Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming">Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Lung Cellular and Molecular Physiology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155562]").text(description); $(".js-view-count[data-work-id=53155562]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155562; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155562']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155562, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155562,"title":"Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming","translated_title":"","metadata":{"abstract":"Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...","publisher":"American Physiological Society","publication_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},"translated_abstract":"Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...","internal_url":"https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming","translated_internal_url":"","created_at":"2021-09-21T13:01:30.841-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"}],"urls":[{"id":11426416,"url":"https://journals.physiology.org/doi/pdf/10.1152/ajplung.00123.2021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood"><img alt="Research paper thumbnail of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood">Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and lik...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155561]").text(description); $(".js-view-count[data-work-id=53155561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155561,"title":"Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood","translated_title":"","metadata":{"abstract":"BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...","publisher":"Cold Spring Harbor Laboratory"},"translated_abstract":"BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...","internal_url":"https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood","translated_internal_url":"","created_at":"2021-09-21T13:01:30.654-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[],"urls":[{"id":11426415,"url":"https://syndication.highwire.org/content/doi/10.1101/2020.10.26.355347"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes"><img alt="Research paper thumbnail of Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes">Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes</a></div><div class="wp-workCard_item"><span>Sleep</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttrauma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155559]").text(description); $(".js-view-count[data-work-id=53155559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155559, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155559,"title":"Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes","translated_title":"","metadata":{"abstract":"Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...","publisher":"Oxford University Press (OUP)","publication_name":"Sleep"},"translated_abstract":"Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...","internal_url":"https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes","translated_internal_url":"","created_at":"2021-09-21T13:01:30.462-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":133324,"name":"Sleep","url":"https://www.academia.edu/Documents/in/Sleep"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426414,"url":"http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz257/31221055/zsz257.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci"><img alt="Research paper thumbnail of International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci" class="work-thumbnail" src="https://attachments.academia-assets.com/70075877/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci">International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci</a></div><div class="wp-workCard_item"><span>Nature Communications</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2f08e2ab12f2d71fec406719848e9a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075877,"asset_id":53155558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155558; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155558]").text(description); $(".js-view-count[data-work-id=53155558]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155558; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155558']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155558, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d2f08e2ab12f2d71fec406719848e9a5" } } $('.js-work-strip[data-work-id=53155558]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155558,"title":"International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci","translated_title":"","metadata":{"abstract":"The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...","publisher":"Springer Science and Business Media LLC","publication_name":"Nature Communications"},"translated_abstract":"The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...","internal_url":"https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci","translated_internal_url":"","created_at":"2021-09-21T13:01:30.278-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075877,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075877/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075877/s41467-019-12576-w-libre.pdf?1632254712=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=D0JEgIm1BHM62ZtF09eLSqe95bcK~mZxxEmWTWEyPzxypfMPixmCq1RnwMkUeTKbsJgE~hncm55~EPgUMAAxhRH9KaXplT4S7Ui0gLCIiLNJVPBwVZcJXWHKCZif3F3PTAvUuyQHCij~M1Rqrxb0e4bZS~nscFPQSn5OwZLoN72UHWN2jexHo9eqmUwrUpILthWhyICOkt4I11kUwRgMQ28lXnm-AG7wf3iE1-6YNi0g2sm2qeefwI5H9yC1EpS1KCTQB-mvp6q9AslvO~mLEa1tpPNfm4tQL6s~jp~4Uit3Hm8NEV-Ap03Wrk8oPHe74dEP9xiUxs41fCyWs~jBjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075877,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075877/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075877/s41467-019-12576-w-libre.pdf?1632254712=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=D0JEgIm1BHM62ZtF09eLSqe95bcK~mZxxEmWTWEyPzxypfMPixmCq1RnwMkUeTKbsJgE~hncm55~EPgUMAAxhRH9KaXplT4S7Ui0gLCIiLNJVPBwVZcJXWHKCZif3F3PTAvUuyQHCij~M1Rqrxb0e4bZS~nscFPQSn5OwZLoN72UHWN2jexHo9eqmUwrUpILthWhyICOkt4I11kUwRgMQ28lXnm-AG7wf3iE1-6YNi0g2sm2qeefwI5H9yC1EpS1KCTQB-mvp6q9AslvO~mLEa1tpPNfm4tQL6s~jp~4Uit3Hm8NEV-Ap03Wrk8oPHe74dEP9xiUxs41fCyWs~jBjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":70075876,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075876/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075876/download_file","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075876/s41467-019-12576-w-libre.pdf?1632254711=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=PLEWkksHs9Pe6ZiO9HKpxP5lUlegoOD-HT2GJjJfBcpCuMIjrqJcWngvU~dD6w6wVeIgQALtmL76j1Z82EUBJvbfFHML4zHheidHXjYpA4RH3rqGc1hpPzhIcMetXnLrJPLcT0EcuN6O47PCv04P9wxIrGRucE~NFxnxxAj7RCgECujnQ2NyQBsSweYv4ssWJZgB9Jhw2Q4WKAuXrUyQfBgYcOL410D7YUwvGOHKNlwvw4eSiDl6ITNhRB-00xQ7EDX3nSexdLnPfWjnX8t6X7-g94PAme1ZIB8kRQ6sBU6njpAsTrbjMchQfuWOph0rpdyjGvfCT1QEcNVfufNM-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"}],"urls":[{"id":11426413,"url":"http://www.nature.com/articles/s41467-019-12576-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain"><img alt="Research paper thumbnail of Transcriptomic Profiles of Sepsis in the Human Brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain">Transcriptomic Profiles of Sepsis in the Human Brain</a></div><div class="wp-workCard_item"><span>A95. CRITICAL CARE: ALICE IN WONDERLAND - BIOMARKERS IN CRITICAL ILLNESS: CLUES TO BE UNRAVELLED</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155557"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155557"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155557; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155557]").text(description); $(".js-view-count[data-work-id=53155557]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155557; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155557']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155557, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155557]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155557,"title":"Transcriptomic Profiles of Sepsis in the Human Brain","translated_title":"","metadata":{"publisher":"American Thoracic Society","publication_name":"A95. CRITICAL CARE: ALICE IN WONDERLAND - BIOMARKERS IN CRITICAL ILLNESS: CLUES TO BE UNRAVELLED"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain","translated_internal_url":"","created_at":"2021-09-21T13:01:30.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice"><img alt="Research paper thumbnail of Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/70075909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice">Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice</a></div><div class="wp-workCard_item"><span>Frontiers in Neuroscience</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fc33770a25ebee628e5988321f762fd7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075909,"asset_id":53155556,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155556]").text(description); $(".js-view-count[data-work-id=53155556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155556, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fc33770a25ebee628e5988321f762fd7" } } $('.js-work-strip[data-work-id=53155556]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155556,"title":"Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysaccharide (LPS)-induced neuroinflammation is not known. We investigated whether the DMNT inhibitor, zebularine, would alter sickness behavior, DNA methylation of the Il-1β promoter and expression of inflammatory genes in hippocampus and microglia. Contrary to our hypothesis that zebularine may exaggerate LPS-induced sickness response and neuroinflammation, adult mice treated with an intracerebroventricular (ICV) injection of zebularine prior to LPS had surprisingly faster recovery of burrowing behavior compared to mice treated with LPS. Further, genes of inflammatory markers, epigenetic regulators, and the microglial sensory apparatus (i.e., the sensome) were differentially expressed by zebularine alone or in combination with LPS. Bisulfite pyrosequencing revealed that ICV zebularine led to decreased DNA methylation of two CpG sites near the Il-1β proximal promoter alone or in combination with LPS. Zebularine treated mice still exhibited decreased DNA methylation 48 h after treatment when LPS-induced sickness behavior as well as hippocampal and microglial gene expression were similar to control mice. Taken together, these data suggest that decreased DNA methylation, specifically of the Il-1β promoter region, with a DNMT inhibitor in the brain disrupts molecular mechanisms of neuroinflammation.","publication_name":"Frontiers in Neuroscience","grobid_abstract_attachment_id":70075909},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice","translated_internal_url":"","created_at":"2021-09-21T13:01:29.973-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075909/thumbnails/1.jpg","file_name":"e6c6b579a1d0e1d619fd1692c4a1d8a76a53.pdf","download_url":"https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_DNA_Methylation_With_Zebul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075909/e6c6b579a1d0e1d619fd1692c4a1d8a76a53-libre.pdf?1632254706=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_DNA_Methylation_With_Zebul.pdf\u0026Expires=1732780602\u0026Signature=ECSqMVFkSeKF703HmGbBesdGHX4AuU8alaQGQ2PhbLd1476~DAzalf0FHvQa3ygmAwr9W~DImJfxYNZLVrk6sXx0atJccQK28kCSzHlfz~~2Jx~6sPVVxP4IvCUuVjDCg2qI61L-OBNLPWD5hLlR7OIU3jLqFVCMxHFLUIIkoWlrIjjSSESgK7YzftIXDTS46r3exYcng4iyXlBJLy1lOXMMNWxi~BiF7-uLKcmX3WVrRNdiytPEMf2mRrnmFBh1-5NEJruMYpTe8kr9hHzBldUKicrOW5-KAgrVlf3lyg9CoufVvdmyeYYe0~UJUSqc6dZzKsJeioqaHn-4Zp9VWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075909/thumbnails/1.jpg","file_name":"e6c6b579a1d0e1d619fd1692c4a1d8a76a53.pdf","download_url":"https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_DNA_Methylation_With_Zebul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075909/e6c6b579a1d0e1d619fd1692c4a1d8a76a53-libre.pdf?1632254706=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_DNA_Methylation_With_Zebul.pdf\u0026Expires=1732780602\u0026Signature=ECSqMVFkSeKF703HmGbBesdGHX4AuU8alaQGQ2PhbLd1476~DAzalf0FHvQa3ygmAwr9W~DImJfxYNZLVrk6sXx0atJccQK28kCSzHlfz~~2Jx~6sPVVxP4IvCUuVjDCg2qI61L-OBNLPWD5hLlR7OIU3jLqFVCMxHFLUIIkoWlrIjjSSESgK7YzftIXDTS46r3exYcng4iyXlBJLy1lOXMMNWxi~BiF7-uLKcmX3WVrRNdiytPEMf2mRrnmFBh1-5NEJruMYpTe8kr9hHzBldUKicrOW5-KAgrVlf3lyg9CoufVvdmyeYYe0~UJUSqc6dZzKsJeioqaHn-4Zp9VWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":11426412,"url":"https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain"><img alt="Research paper thumbnail of Epigenetic profiles associated with major depression in the human brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain">Epigenetic profiles associated with major depression in the human brain</a></div><div class="wp-workCard_item"><span>Psychiatry Research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155555; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155555]").text(description); $(".js-view-count[data-work-id=53155555]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155555; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155555']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155555, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155555]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155555,"title":"Epigenetic profiles associated with major depression in the human brain","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Psychiatry Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain","translated_internal_url":"","created_at":"2021-09-21T13:01:29.794-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Epigenetic_profiles_associated_with_major_depression_in_the_human_brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":635,"name":"Psychiatry","url":"https://www.academia.edu/Documents/in/Psychiatry"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426411,"url":"https://api.elsevier.com/content/article/PII:S0165178117311861?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways"><img alt="Research paper thumbnail of Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways" class="work-thumbnail" src="https://attachments.academia-assets.com/70075906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways">Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD fol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson&#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="717cc0ae1ff05e10f9d91e3a25efaeaf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075906,"asset_id":53155554,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155554]").text(description); $(".js-view-count[data-work-id=53155554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155554, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "717cc0ae1ff05e10f9d91e3a25efaeaf" } } $('.js-work-strip[data-work-id=53155554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155554,"title":"Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways","translated_title":"","metadata":{"abstract":"Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson\u0026#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...","publisher":"Cold Spring Harbor Laboratory"},"translated_abstract":"Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson\u0026#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...","internal_url":"https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways","translated_internal_url":"","created_at":"2021-09-21T13:01:29.611-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075906/thumbnails/1.jpg","file_name":"458562.full.pdf","download_url":"https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Largest_genome_wide_association_study_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075906/458562.full-libre.pdf?1632254713=\u0026response-content-disposition=attachment%3B+filename%3DLargest_genome_wide_association_study_fo.pdf\u0026Expires=1732780602\u0026Signature=BBkumFuqs12X4LZVeqzmy6yNzr9gKxroWEcNczCdZWMQzdh0Bsg0ICb5aa9u2Mk1vxtKAFBh6duKPjabk3wNm8F0etpg8nE8qg1EYNNBPZzMSueiKW-9QGnepXrLi~i8VYWpqB1BHcnZ1kUsQ~kWsEYnoECbs2zNHukUyi7CjJGq43vNhlje9Xcl5UxRAuDMItLhvuZX6MlPrP02jeQ2c8D0axShz3s7OdkG~7JIJAXqrZ39aopZef7TEoMjkel~tsBgk0hTShOUdFNiclUKikhiCRBbM27nkj9asEpY19uXycZ7NHR-sLzjsaHgc-51GDtjqAVEN~3-HbSQV6h5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways","translated_slug":"","page_count":78,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075906/thumbnails/1.jpg","file_name":"458562.full.pdf","download_url":"https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Largest_genome_wide_association_study_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075906/458562.full-libre.pdf?1632254713=\u0026response-content-disposition=attachment%3B+filename%3DLargest_genome_wide_association_study_fo.pdf\u0026Expires=1732780602\u0026Signature=BBkumFuqs12X4LZVeqzmy6yNzr9gKxroWEcNczCdZWMQzdh0Bsg0ICb5aa9u2Mk1vxtKAFBh6duKPjabk3wNm8F0etpg8nE8qg1EYNNBPZzMSueiKW-9QGnepXrLi~i8VYWpqB1BHcnZ1kUsQ~kWsEYnoECbs2zNHukUyi7CjJGq43vNhlje9Xcl5UxRAuDMItLhvuZX6MlPrP02jeQ2c8D0axShz3s7OdkG~7JIJAXqrZ39aopZef7TEoMjkel~tsBgk0hTShOUdFNiclUKikhiCRBbM27nkj9asEpY19uXycZ7NHR-sLzjsaHgc-51GDtjqAVEN~3-HbSQV6h5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":11426410,"url":"https://syndication.highwire.org/content/doi/10.1101/458562"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression"><img alt="Research paper thumbnail of 501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression">501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression</a></div><div class="wp-workCard_item"><span>Biological Psychiatry</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155553]").text(description); $(".js-view-count[data-work-id=53155553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155553,"title":"501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Biological Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression","translated_internal_url":"","created_at":"2021-09-21T13:01:29.403-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":49600,"name":"Biological Psychiatry","url":"https://www.academia.edu/Documents/in/Biological_Psychiatry"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426408,"url":"http://api.elsevier.com/content/article/PII:S0006322317312313?httpAccept=text/plain"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study">FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item"><span>Journal of Psychiatric Research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155551]").text(description); $(".js-view-count[data-work-id=53155551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155551, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155551,"title":"FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Journal of Psychiatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2021-09-21T13:01:29.217-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":621186,"name":"Psychiatric","url":"https://www.academia.edu/Documents/in/Psychiatric"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426407,"url":"http://api.elsevier.com/content/article/PII:S0022395617303126?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression"><img alt="Research paper thumbnail of Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression">Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression</a></div><div class="wp-workCard_item"><span>Journal of Affective Disorders</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155550]").text(description); $(".js-view-count[data-work-id=53155550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155550,"title":"Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Affective Disorders"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression","translated_internal_url":"","created_at":"2021-09-21T13:01:29.107-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":67516,"name":"Affective Disorders","url":"https://www.academia.edu/Documents/in/Affective_Disorders"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155549"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression"><img alt="Research paper thumbnail of Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression" class="work-thumbnail" src="https://attachments.academia-assets.com/70075905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression">Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression</a></div><div class="wp-workCard_item"><span>Nature communications</span><span>, Jan 3, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2283a7350c15be0582884ac1f3f8f1af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075905,"asset_id":53155549,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155549"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155549]").text(description); $(".js-view-count[data-work-id=53155549]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155549']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155549, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2283a7350c15be0582884ac1f3f8f1af" } } $('.js-work-strip[data-work-id=53155549]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155549,"title":"Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression","translated_title":"","metadata":{"grobid_abstract":"The original version of this Article contained an error in the spelling of the author Jennifer S. Stevens, which was incorrectly given as Jennifer J. Stevens. Furthermore, in Fig. 5, the titles for panels a and b were inadvertently switched. Both of these errors have now been corrected in the PDF and HTML versions of the Article.","publication_date":{"day":3,"month":1,"year":2016,"errors":{}},"publication_name":"Nature communications","grobid_abstract_attachment_id":70075905},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_internal_url":"","created_at":"2021-09-21T13:01:28.994-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075905/thumbnails/1.jpg","file_name":"pmc4782056.pdf","download_url":"https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Corrigendum_DICER1_and_microRNA_regulati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075905/pmc4782056-libre.pdf?1632254704=\u0026response-content-disposition=attachment%3B+filename%3DCorrigendum_DICER1_and_microRNA_regulati.pdf\u0026Expires=1732780602\u0026Signature=Sig4Pb2nQUgmM4nFW2vTMvz1FcR~k83cyajZyUpkGCX9EtjW7~n1OnPfWTDYpwYYUueJC-sNEWvs~SDBGYB5Uo01w05QrNY8P0px1OUR1MrmMICCNt56K3YsuhpzUM9QT49AT6SeVvG2wObrPJOKJBq6aWQT2T-jrqDj7c-Hl0muLDezEtDncgzxwjtJvYuvEEOQPnralR8DJ0HS1LrASf28Xh5yumgzzx756Ovxb6UoxdcodhfzqKrfKfP8aQvVbUChLi7BV0gEUB06Tbw4hhd8vCGu9ZvdOupepY9JXeyamiNTh~CC15zxM45js1hEOC~-MlX9DCYwHp-aKrXe0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075905/thumbnails/1.jpg","file_name":"pmc4782056.pdf","download_url":"https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Corrigendum_DICER1_and_microRNA_regulati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075905/pmc4782056-libre.pdf?1632254704=\u0026response-content-disposition=attachment%3B+filename%3DCorrigendum_DICER1_and_microRNA_regulati.pdf\u0026Expires=1732780602\u0026Signature=Sig4Pb2nQUgmM4nFW2vTMvz1FcR~k83cyajZyUpkGCX9EtjW7~n1OnPfWTDYpwYYUueJC-sNEWvs~SDBGYB5Uo01w05QrNY8P0px1OUR1MrmMICCNt56K3YsuhpzUM9QT49AT6SeVvG2wObrPJOKJBq6aWQT2T-jrqDj7c-Hl0muLDezEtDncgzxwjtJvYuvEEOQPnralR8DJ0HS1LrASf28Xh5yumgzzx756Ovxb6UoxdcodhfzqKrfKfP8aQvVbUChLi7BV0gEUB06Tbw4hhd8vCGu9ZvdOupepY9JXeyamiNTh~CC15zxM45js1hEOC~-MlX9DCYwHp-aKrXe0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155548"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression"><img alt="Research paper thumbnail of DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression" class="work-thumbnail" src="https://attachments.academia-assets.com/70075910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression">DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression</a></div><div class="wp-workCard_item"><span>Nature communications</span><span>, Jan 3, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3&#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD&Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a05b0b8af27052202022aa6ffeffdcf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075910,"asset_id":53155548,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155548"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155548"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155548; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155548]").text(description); $(".js-view-count[data-work-id=53155548]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155548; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155548']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155548, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a05b0b8af27052202022aa6ffeffdcf" } } $('.js-work-strip[data-work-id=53155548]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155548,"title":"DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression","translated_title":"","metadata":{"abstract":"DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD\u0026Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3\u0026#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD\u0026Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD\u0026Dep reveals miRNAs to be significantly downregulated...","publication_date":{"day":3,"month":1,"year":2015,"errors":{}},"publication_name":"Nature communications"},"translated_abstract":"DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD\u0026Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3\u0026#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD\u0026Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD\u0026Dep reveals miRNAs to be significantly downregulated...","internal_url":"https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_internal_url":"","created_at":"2021-09-21T13:01:28.885-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075910/thumbnails/1.jpg","file_name":"4686835.pdf","download_url":"https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DICER1_and_microRNA_regulation_in_post_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075910/4686835-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DDICER1_and_microRNA_regulation_in_post_t.pdf\u0026Expires=1732780602\u0026Signature=GGSAP2eCmziDzFvoiU7sBZ3rq3zdBBybH9ZClu-vV-5-jT5L~CDsZcahQiURNHkznl17YsFcCois-LtRZ-roOq1PgjFH5~d4SYOqoXAMUH0hqJ~txQETo4irmiREYqzVMWYKtsKUAi-7jGsCsCd4BOoaYt88xRZswbCNCKNVPKmBVPtiA~OeVCKlgRBKKnEQ2~fpiLESDGKC3BpBLrS59i9Tbi9TH4r20Qt8axqRgP4aeGN8PMLilt8MRXQld8pmIQfeK-0BToxPlUjNtUAYzJ-NUoeztrL2ycPyc7zrrVsU67-Zmd-OTB-IeizSaaSbjBCj7~4l0VI34lpLmBkUMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075910/thumbnails/1.jpg","file_name":"4686835.pdf","download_url":"https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DICER1_and_microRNA_regulation_in_post_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075910/4686835-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DDICER1_and_microRNA_regulation_in_post_t.pdf\u0026Expires=1732780602\u0026Signature=GGSAP2eCmziDzFvoiU7sBZ3rq3zdBBybH9ZClu-vV-5-jT5L~CDsZcahQiURNHkznl17YsFcCois-LtRZ-roOq1PgjFH5~d4SYOqoXAMUH0hqJ~txQETo4irmiREYqzVMWYKtsKUAi-7jGsCsCd4BOoaYt88xRZswbCNCKNVPKmBVPtiA~OeVCKlgRBKKnEQ2~fpiLESDGKC3BpBLrS59i9Tbi9TH4r20Qt8axqRgP4aeGN8PMLilt8MRXQld8pmIQfeK-0BToxPlUjNtUAYzJ-NUoeztrL2ycPyc7zrrVsU67-Zmd-OTB-IeizSaaSbjBCj7~4l0VI34lpLmBkUMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression"},{"id":3931,"name":"Fear","url":"https://www.academia.edu/Documents/in/Fear"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":159962,"name":"Amygdala","url":"https://www.academia.edu/Documents/in/Amygdala"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":2039739,"name":"Down-Regulation","url":"https://www.academia.edu/Documents/in/Down-Regulation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155547"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology"><img alt="Research paper thumbnail of Epidemiology, Epigenetics, and Psychopathology" class="work-thumbnail" src="https://attachments.academia-assets.com/70075907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology">Epidemiology, Epigenetics, and Psychopathology</a></div><div class="wp-workCard_item"><span>Medical Epigenetics</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f571daa5413810bec8e9ceaf0478227" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075907,"asset_id":53155547,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155547"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155547"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155547; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155547]").text(description); $(".js-view-count[data-work-id=53155547]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155547; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155547']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155547, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f571daa5413810bec8e9ceaf0478227" } } $('.js-work-strip[data-work-id=53155547]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155547,"title":"Epidemiology, Epigenetics, and Psychopathology","translated_title":"","metadata":{"publisher":"S. Karger AG","ai_title_tag":"Linking Epigenetics and Psychopathology: A Review","grobid_abstract":"The link between environmental exposure and onset of psychopathology has been well documented, yet the pathway is not fully understood. Epigenetic modifications are thought to play a role in the manifestation of disease as studies have shown that early environmental exposures can influence epigenetic variation in both humans and other animals. As a result, epigenetic epidemiology studies with a specific focus on psychopathology will play an important role in elucidating the pathway to disease onset. In order to gain a clear perspective of where this field currently stands, here we provide a brief review of important issues in epigenetic epidemiology studies of psychopathology, including causal inference, common study designs, challenges faced with current study designs, and the importance of a life course perspective. We provide the reader with relevant examples of studies when appropriate, with a particular focus on studies that have examined the epigenetic modification of DNA methylation. Implications for future research are also discussed.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Medical Epigenetics","grobid_abstract_attachment_id":70075907},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology","translated_internal_url":"","created_at":"2021-09-21T13:01:28.777-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075907/thumbnails/1.jpg","file_name":"362762.pdf","download_url":"https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epidemiology_Epigenetics_and_Psychopatho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075907/362762-libre.pdf?1632254710=\u0026response-content-disposition=attachment%3B+filename%3DEpidemiology_Epigenetics_and_Psychopatho.pdf\u0026Expires=1732780602\u0026Signature=dSMSMI8uxa~Lzn-ktp7wPtQEuTx71z2dO3oLpjBLlW2vnaAs0qIpy0RSYEolaYoeOxCDIAyfkyYruyAlDYRq3lGRKSeIY-pB-wAkn8WZw0zdk1RFA1JvgseXR02NijD5gZZVNosaAc2WPNYh6pDVQQ~TvaWayWZ21FHQHXazJWHxVgwogf8p-xNRiTi6wf3ZRv5huHevCb~MI2XOmblS5B1grhJHEic3Qmvv7dVZa7wEgA3hBLc7L0CirIT7OUs1OaRHm0-E28EtTPFwVyMh-IuT6SP1cS8OtnPXyXhCFld2tmDyJBOf93sCwukJB6fcNpIHSnzPVN-3KkvK0sHSIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Epidemiology_Epigenetics_and_Psychopathology","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075907/thumbnails/1.jpg","file_name":"362762.pdf","download_url":"https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epidemiology_Epigenetics_and_Psychopatho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075907/362762-libre.pdf?1632254710=\u0026response-content-disposition=attachment%3B+filename%3DEpidemiology_Epigenetics_and_Psychopatho.pdf\u0026Expires=1732780602\u0026Signature=dSMSMI8uxa~Lzn-ktp7wPtQEuTx71z2dO3oLpjBLlW2vnaAs0qIpy0RSYEolaYoeOxCDIAyfkyYruyAlDYRq3lGRKSeIY-pB-wAkn8WZw0zdk1RFA1JvgseXR02NijD5gZZVNosaAc2WPNYh6pDVQQ~TvaWayWZ21FHQHXazJWHxVgwogf8p-xNRiTi6wf3ZRv5huHevCb~MI2XOmblS5B1grhJHEic3Qmvv7dVZa7wEgA3hBLc7L0CirIT7OUs1OaRHm0-E28EtTPFwVyMh-IuT6SP1cS8OtnPXyXhCFld2tmDyJBOf93sCwukJB6fcNpIHSnzPVN-3KkvK0sHSIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155546"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses"><img alt="Research paper thumbnail of Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses" class="work-thumbnail" src="https://attachments.academia-assets.com/70075930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses">Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses</a></div><div class="wp-workCard_item"><span>Frontiers in Psychiatry</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da8de4b7dd635637e8f557a0fb63424e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075930,"asset_id":53155546,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155546"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155546"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155546; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155546]").text(description); $(".js-view-count[data-work-id=53155546]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155546; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155546']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155546, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "da8de4b7dd635637e8f557a0fb63424e" } } $('.js-work-strip[data-work-id=53155546]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155546,"title":"Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"The recent sociodevelopmental cognitive model of schizophrenia/psychosis is a highly influential and compelling compendium of research findings. Here, we present logical extensions to this model incorporating ideas drawn from epigenetic mediation of psychiatric disease, and the plausible effects of epigenetics on the emergence of brain network function and dysfunction in adolescence. We discuss how gene-environment interactions, effected by epigenetic mechanisms, might in particular mediate the stress response (itself heavily implicated in the emergence of schizophrenia). Next, we discuss the plausible relevance of this framework for adolescent genetic risk populations, a risk group characterized by vexing and difficult-to-explain heterogeneity. We then discuss how exploring relationships between epigenetics and brain network dysfunction (a strongly validated finding in risk populations) can enhance understanding of the relationship between stress, epigenetics, and functional neurobiology, and the relevance of this relationship for the eventual emergence of schizophrenia/psychosis. We suggest that these considerations can expand the impact of models such as the sociodevelopmental cognitive model, increasing their explanatory reach. Ultimately, integration of these lines of research may enhance efforts of early identification, intervention, and treatment in adolescents at-risk for schizophrenia.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Frontiers in Psychiatry","grobid_abstract_attachment_id":70075930},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses","translated_internal_url":"","created_at":"2021-09-21T13:01:28.668-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075930/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epigenetics_Stress_and_Their_Potential_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075930/pdf-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DEpigenetics_Stress_and_Their_Potential_I.pdf\u0026Expires=1732780602\u0026Signature=Yi6S0zNrag4H3kFw47VTh-9P65zctvZNUVMIyjSrA0GtokDhi2Fldrffmf8kWsW0-1vRn1yq-rTG3cP6-xyUgj429cMqXDDnSzBxg~b88Ck755MDmuJfMSEoK8efD-uP6rtA-Qd~wGXpLWacloc4pteLkojYRIn536~33D2DzgVr9SGwXQG2CndWxYCsBihdnEv1Z40i598ZuYdvu1ogFTkyGUmoq0ZdF3g3OPbNTNPcKkezRFnzYeGnhyWY1G9M9LmXsVSsZ3m88jAbw1C7-w8kRIxuD73AcymR0xLRc-kUBe4b89A~XrB4T2fVHgp3iADlBxqL2~DhfplmTHYm4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075930/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epigenetics_Stress_and_Their_Potential_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075930/pdf-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DEpigenetics_Stress_and_Their_Potential_I.pdf\u0026Expires=1732780602\u0026Signature=Yi6S0zNrag4H3kFw47VTh-9P65zctvZNUVMIyjSrA0GtokDhi2Fldrffmf8kWsW0-1vRn1yq-rTG3cP6-xyUgj429cMqXDDnSzBxg~b88Ck755MDmuJfMSEoK8efD-uP6rtA-Qd~wGXpLWacloc4pteLkojYRIn536~33D2DzgVr9SGwXQG2CndWxYCsBihdnEv1Z40i598ZuYdvu1ogFTkyGUmoq0ZdF3g3OPbNTNPcKkezRFnzYeGnhyWY1G9M9LmXsVSsZ3m88jAbw1C7-w8kRIxuD73AcymR0xLRc-kUBe4b89A~XrB4T2fVHgp3iADlBxqL2~DhfplmTHYm4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk"},{"id":22404,"name":"Epigenetics","url":"https://www.academia.edu/Documents/in/Epigenetics"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155545"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders"><img alt="Research paper thumbnail of Epigenetic Epidemiology of Psychiatric Disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders">Epigenetic Epidemiology of Psychiatric Disorders</a></div><div class="wp-workCard_item"><span>Epigenetics in Psychiatry</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155545"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155545"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155545; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155545]").text(description); $(".js-view-count[data-work-id=53155545]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155545; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155545']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155545, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155545]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155545,"title":"Epigenetic Epidemiology of Psychiatric Disorders","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Epigenetics in Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders","translated_internal_url":"","created_at":"2021-09-21T13:01:28.552-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Epigenetic_Epidemiology_of_Psychiatric_Disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":28523,"name":"Causal Inference","url":"https://www.academia.edu/Documents/in/Causal_Inference"},{"id":82845,"name":"Effect size","url":"https://www.academia.edu/Documents/in/Effect_size"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study">Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item"><span>Comprehensive Psychiatry</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155482]").text(description); $(".js-view-count[data-work-id=53155482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155482,"title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publication_name":"Comprehensive Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2021-09-21T13:00:31.329-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22605646"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study">Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://illinois.academia.edu/DWildman">Derek Wildman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AngelaBustamante2">Angela Bustamante</a></span></div><div class="wp-workCard_item"><span>Comprehensive Psychiatry</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22605646"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22605646"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22605646; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22605646]").text(description); $(".js-view-count[data-work-id=22605646]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22605646; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22605646']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22605646, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22605646]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22605646,"title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Comprehensive Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2016-02-29T09:10:15.336-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44163928,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":16307631,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":null,"co_author_invite_id":254647,"email":"k***5@columbia.edu","display_order":0,"name":"Karestan Koenen","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307720,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":53487504,"co_author_invite_id":674239,"email":"a***o@email.unc.edu","display_order":4194304,"name":"Allison Aiello","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307748,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":null,"co_author_invite_id":1057349,"email":"s***a@bu.edu","display_order":6291456,"name":"Sandro Galea","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307878,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":44194127,"co_author_invite_id":3755714,"email":"a***2@illinois.edu","display_order":7340032,"name":"Angela Bustamante","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"}],"downloadable_attachments":[],"slug":"Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44163928,"first_name":"Derek","middle_initials":null,"last_name":"Wildman","page_name":"DWildman","domain_name":"illinois","created_at":"2016-02-29T09:09:40.545-08:00","display_name":"Derek Wildman","url":"https://illinois.academia.edu/DWildman","email":"dloyclNhc3gwZFAwT0NDUHhnUUlDbEt6NDNoSEEzOGpCM0QzcmUzWjduST0tLS84SnJOT0tBQWhVSC93eXJsQm5IM0E9PQ==--71ace2162daa8e07299388a7c743467e7ce9069f"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div><div class="profile--tab_content_container js-tab-pane tab-pane" data-section-id="4718380" id="papers"><div class="js-work-strip profile--work_container" data-work-id="53155562"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming"><img alt="Research paper thumbnail of Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming">Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming</a></div><div class="wp-workCard_item"><span>American Journal of Physiology-Lung Cellular and Molecular Physiology</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155562"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155562"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155562; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155562]").text(description); $(".js-view-count[data-work-id=53155562]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155562; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155562']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155562, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155562]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155562,"title":"Long-term survivors of murine sepsis are predisposed to enhanced LPS-induced lung injury and pro-inflammatory immune reprogramming","translated_title":"","metadata":{"abstract":"Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...","publisher":"American Physiological Society","publication_name":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},"translated_abstract":"Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. In order to prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the form of immunoparalysis and impaired host defense is proposed to mediate late pulmonary complications after sepsis, particularly new pulmonary infections. However, immune reprogramming may also involve enhanced/primed responses to secondary stimuli, although their contribution to long-term sepsis complications remains understudied. We hypothesize that enhanced/primed immune responses in the lungs of sepsis survivors are associated with late pulmonary complications. To this end, we developed a murine sepsis model using cecal ligation and puncture (CLP) followed 3 weeks later by administration of intranasal lipopolysaccharide to induce inflammatory lung injury. Mice surviving sepsis exhibit enhanced lung injury with increased alveol...","internal_url":"https://www.academia.edu/53155562/Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming","translated_internal_url":"","created_at":"2021-09-21T13:01:30.841-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Long_term_survivors_of_murine_sepsis_are_predisposed_to_enhanced_LPS_induced_lung_injury_and_pro_inflammatory_immune_reprogramming","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":167,"name":"Physiology","url":"https://www.academia.edu/Documents/in/Physiology"},{"id":186234,"name":"Medical Physiology","url":"https://www.academia.edu/Documents/in/Medical_Physiology"}],"urls":[{"id":11426416,"url":"https://journals.physiology.org/doi/pdf/10.1152/ajplung.00123.2021"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155561"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood"><img alt="Research paper thumbnail of Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood">Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and lik...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155561"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155561"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155561; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155561]").text(description); $(".js-view-count[data-work-id=53155561]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155561; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155561']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155561, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155561]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155561,"title":"Associations between childhood family emotional health, fronto-limbic grey matter volume, and saliva 5mC in young adulthood","translated_title":"","metadata":{"abstract":"BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...","publisher":"Cold Spring Harbor Laboratory"},"translated_abstract":"BackgroundPoor family emotional health (FEH) during childhood is prevalent and impactful, and likely confers similar neurodevelopmental risks as other adverse social environments. Pointed FEH study efforts are underdeveloped, and the mechanisms by which poor FEH are biologically embedded are unclear. The current exploratory study examined whether variability in DNA methylation (DNAm) and fronto-limbic grey matter volume may represent pathways through which FEH may become biologically embedded.ResultsSelf-reported childhood FEH was nominally associated with right hemisphere hippocampus (b=10.4, p=0.005), left hemisphere amygdala (b=5.3, p=0.009), and right hemisphere amygdala (b=5.8, p=0.016) volumes. Childhood FEH was also nominally associated with 49 DNAm MEs (prange=3×10−6 to 0.047). After limiting analyses to probes correlated between saliva and brain, saliva-derived DNAm MEs partially mediated the association between FEH and right hippocampal volume (Burlywood ME indirect effect...","internal_url":"https://www.academia.edu/53155561/Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood","translated_internal_url":"","created_at":"2021-09-21T13:01:30.654-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Associations_between_childhood_family_emotional_health_fronto_limbic_grey_matter_volume_and_saliva_5mC_in_young_adulthood","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[],"urls":[{"id":11426415,"url":"https://syndication.highwire.org/content/doi/10.1101/2020.10.26.355347"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155559"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes"><img alt="Research paper thumbnail of Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes">Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes</a></div><div class="wp-workCard_item"><span>Sleep</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttrauma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155559"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155559"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155559; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155559]").text(description); $(".js-view-count[data-work-id=53155559]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155559; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155559']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155559, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155559]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155559,"title":"Molecular genetic overlap between posttraumatic stress disorder and sleep phenotypes","translated_title":"","metadata":{"abstract":"Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...","publisher":"Oxford University Press (OUP)","publication_name":"Sleep"},"translated_abstract":"Study Objectives Sleep problems are common, serving as both a predictor and symptom of posttraumatic stress disorder (PTSD), with these bidirectional relationships well established in the literature. While both sleep phenotypes and PTSD are moderately heritable, there has been a paucity of investigation into potential genetic overlap between sleep and PTSD. Here, we estimate genetic correlations between multiple sleep phenotypes (including insomnia symptoms, sleep duration, daytime sleepiness, and chronotype) and PTSD, using results from the largest genome-wide association study (GWAS) to date of PTSD, as well as publicly available GWAS results for sleep phenotypes within UK Biobank data (23 variations, encompassing four main phenotypes). Methods Genetic correlations were estimated utilizing linkage disequilibrium score regression (LDSC), an approach that uses GWAS summary statistics to compute genetic correlations across traits, and Mendelian randomization (MR) analyses were conduc...","internal_url":"https://www.academia.edu/53155559/Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes","translated_internal_url":"","created_at":"2021-09-21T13:01:30.462-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Molecular_genetic_overlap_between_posttraumatic_stress_disorder_and_sleep_phenotypes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":133324,"name":"Sleep","url":"https://www.academia.edu/Documents/in/Sleep"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426414,"url":"http://academic.oup.com/sleep/advance-article-pdf/doi/10.1093/sleep/zsz257/31221055/zsz257.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155558"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci"><img alt="Research paper thumbnail of International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci" class="work-thumbnail" src="https://attachments.academia-assets.com/70075877/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci">International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci</a></div><div class="wp-workCard_item"><span>Nature Communications</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d2f08e2ab12f2d71fec406719848e9a5" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075877,"asset_id":53155558,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155558"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155558"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155558; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155558]").text(description); $(".js-view-count[data-work-id=53155558]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155558; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155558']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155558, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d2f08e2ab12f2d71fec406719848e9a5" } } $('.js-work-strip[data-work-id=53155558]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155558,"title":"International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci","translated_title":"","metadata":{"abstract":"The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...","publisher":"Springer Science and Business Media LLC","publication_name":"Nature Communications"},"translated_abstract":"The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and exp...","internal_url":"https://www.academia.edu/53155558/International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci","translated_internal_url":"","created_at":"2021-09-21T13:01:30.278-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075877,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075877/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075877/s41467-019-12576-w-libre.pdf?1632254712=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=D0JEgIm1BHM62ZtF09eLSqe95bcK~mZxxEmWTWEyPzxypfMPixmCq1RnwMkUeTKbsJgE~hncm55~EPgUMAAxhRH9KaXplT4S7Ui0gLCIiLNJVPBwVZcJXWHKCZif3F3PTAvUuyQHCij~M1Rqrxb0e4bZS~nscFPQSn5OwZLoN72UHWN2jexHo9eqmUwrUpILthWhyICOkt4I11kUwRgMQ28lXnm-AG7wf3iE1-6YNi0g2sm2qeefwI5H9yC1EpS1KCTQB-mvp6q9AslvO~mLEa1tpPNfm4tQL6s~jp~4Uit3Hm8NEV-Ap03Wrk8oPHe74dEP9xiUxs41fCyWs~jBjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"International_meta_analysis_of_PTSD_genome_wide_association_studies_identifies_sex_and_ancestry_specific_genetic_risk_loci","translated_slug":"","page_count":16,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075877,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075877/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075877/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMSw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075877/s41467-019-12576-w-libre.pdf?1632254712=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=D0JEgIm1BHM62ZtF09eLSqe95bcK~mZxxEmWTWEyPzxypfMPixmCq1RnwMkUeTKbsJgE~hncm55~EPgUMAAxhRH9KaXplT4S7Ui0gLCIiLNJVPBwVZcJXWHKCZif3F3PTAvUuyQHCij~M1Rqrxb0e4bZS~nscFPQSn5OwZLoN72UHWN2jexHo9eqmUwrUpILthWhyICOkt4I11kUwRgMQ28lXnm-AG7wf3iE1-6YNi0g2sm2qeefwI5H9yC1EpS1KCTQB-mvp6q9AslvO~mLEa1tpPNfm4tQL6s~jp~4Uit3Hm8NEV-Ap03Wrk8oPHe74dEP9xiUxs41fCyWs~jBjw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"},{"id":70075876,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075876/thumbnails/1.jpg","file_name":"s41467-019-12576-w.pdf","download_url":"https://www.academia.edu/attachments/70075876/download_file","bulk_download_file_name":"International_meta_analysis_of_PTSD_geno.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075876/s41467-019-12576-w-libre.pdf?1632254711=\u0026response-content-disposition=attachment%3B+filename%3DInternational_meta_analysis_of_PTSD_geno.pdf\u0026Expires=1732780601\u0026Signature=PLEWkksHs9Pe6ZiO9HKpxP5lUlegoOD-HT2GJjJfBcpCuMIjrqJcWngvU~dD6w6wVeIgQALtmL76j1Z82EUBJvbfFHML4zHheidHXjYpA4RH3rqGc1hpPzhIcMetXnLrJPLcT0EcuN6O47PCv04P9wxIrGRucE~NFxnxxAj7RCgECujnQ2NyQBsSweYv4ssWJZgB9Jhw2Q4WKAuXrUyQfBgYcOL410D7YUwvGOHKNlwvw4eSiDl6ITNhRB-00xQ7EDX3nSexdLnPfWjnX8t6X7-g94PAme1ZIB8kRQ6sBU6njpAsTrbjMchQfuWOph0rpdyjGvfCT1QEcNVfufNM-A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"}],"urls":[{"id":11426413,"url":"http://www.nature.com/articles/s41467-019-12576-w.pdf"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155557"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain"><img alt="Research paper thumbnail of Transcriptomic Profiles of Sepsis in the Human Brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain">Transcriptomic Profiles of Sepsis in the Human Brain</a></div><div class="wp-workCard_item"><span>A95. CRITICAL CARE: ALICE IN WONDERLAND - BIOMARKERS IN CRITICAL ILLNESS: CLUES TO BE UNRAVELLED</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155557"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155557"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155557; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155557]").text(description); $(".js-view-count[data-work-id=53155557]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155557; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155557']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155557, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155557]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155557,"title":"Transcriptomic Profiles of Sepsis in the Human Brain","translated_title":"","metadata":{"publisher":"American Thoracic Society","publication_name":"A95. CRITICAL CARE: ALICE IN WONDERLAND - BIOMARKERS IN CRITICAL ILLNESS: CLUES TO BE UNRAVELLED"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155557/Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain","translated_internal_url":"","created_at":"2021-09-21T13:01:30.160-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Transcriptomic_Profiles_of_Sepsis_in_the_Human_Brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155556"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice"><img alt="Research paper thumbnail of Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice" class="work-thumbnail" src="https://attachments.academia-assets.com/70075909/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice">Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice</a></div><div class="wp-workCard_item"><span>Frontiers in Neuroscience</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="fc33770a25ebee628e5988321f762fd7" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075909,"asset_id":53155556,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155556"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155556"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155556; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155556]").text(description); $(".js-view-count[data-work-id=53155556]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155556; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155556']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155556, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "fc33770a25ebee628e5988321f762fd7" } } $('.js-work-strip[data-work-id=53155556]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155556,"title":"Inhibition of DNA Methylation With Zebularine Alters Lipopolysaccharide-Induced Sickness Behavior and Neuroinflammation in Mice","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"Activity of DNA methyltransferases (DNMTs), the enzymes that catalyze DNA methylation, is dynamically regulated in the brain. DNMT inhibitors alter DNA methylation globally in the brain and at individual neural plasticity-associated genes, but how DNMT inhibitors centrally influence lipopolysaccharide (LPS)-induced neuroinflammation is not known. We investigated whether the DMNT inhibitor, zebularine, would alter sickness behavior, DNA methylation of the Il-1β promoter and expression of inflammatory genes in hippocampus and microglia. Contrary to our hypothesis that zebularine may exaggerate LPS-induced sickness response and neuroinflammation, adult mice treated with an intracerebroventricular (ICV) injection of zebularine prior to LPS had surprisingly faster recovery of burrowing behavior compared to mice treated with LPS. Further, genes of inflammatory markers, epigenetic regulators, and the microglial sensory apparatus (i.e., the sensome) were differentially expressed by zebularine alone or in combination with LPS. Bisulfite pyrosequencing revealed that ICV zebularine led to decreased DNA methylation of two CpG sites near the Il-1β proximal promoter alone or in combination with LPS. Zebularine treated mice still exhibited decreased DNA methylation 48 h after treatment when LPS-induced sickness behavior as well as hippocampal and microglial gene expression were similar to control mice. Taken together, these data suggest that decreased DNA methylation, specifically of the Il-1β promoter region, with a DNMT inhibitor in the brain disrupts molecular mechanisms of neuroinflammation.","publication_name":"Frontiers in Neuroscience","grobid_abstract_attachment_id":70075909},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155556/Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice","translated_internal_url":"","created_at":"2021-09-21T13:01:29.973-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075909/thumbnails/1.jpg","file_name":"e6c6b579a1d0e1d619fd1692c4a1d8a76a53.pdf","download_url":"https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_DNA_Methylation_With_Zebul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075909/e6c6b579a1d0e1d619fd1692c4a1d8a76a53-libre.pdf?1632254706=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_DNA_Methylation_With_Zebul.pdf\u0026Expires=1732780602\u0026Signature=ECSqMVFkSeKF703HmGbBesdGHX4AuU8alaQGQ2PhbLd1476~DAzalf0FHvQa3ygmAwr9W~DImJfxYNZLVrk6sXx0atJccQK28kCSzHlfz~~2Jx~6sPVVxP4IvCUuVjDCg2qI61L-OBNLPWD5hLlR7OIU3jLqFVCMxHFLUIIkoWlrIjjSSESgK7YzftIXDTS46r3exYcng4iyXlBJLy1lOXMMNWxi~BiF7-uLKcmX3WVrRNdiytPEMf2mRrnmFBh1-5NEJruMYpTe8kr9hHzBldUKicrOW5-KAgrVlf3lyg9CoufVvdmyeYYe0~UJUSqc6dZzKsJeioqaHn-4Zp9VWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Inhibition_of_DNA_Methylation_With_Zebularine_Alters_Lipopolysaccharide_Induced_Sickness_Behavior_and_Neuroinflammation_in_Mice","translated_slug":"","page_count":10,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075909,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075909/thumbnails/1.jpg","file_name":"e6c6b579a1d0e1d619fd1692c4a1d8a76a53.pdf","download_url":"https://www.academia.edu/attachments/70075909/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Inhibition_of_DNA_Methylation_With_Zebul.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075909/e6c6b579a1d0e1d619fd1692c4a1d8a76a53-libre.pdf?1632254706=\u0026response-content-disposition=attachment%3B+filename%3DInhibition_of_DNA_Methylation_With_Zebul.pdf\u0026Expires=1732780602\u0026Signature=ECSqMVFkSeKF703HmGbBesdGHX4AuU8alaQGQ2PhbLd1476~DAzalf0FHvQa3ygmAwr9W~DImJfxYNZLVrk6sXx0atJccQK28kCSzHlfz~~2Jx~6sPVVxP4IvCUuVjDCg2qI61L-OBNLPWD5hLlR7OIU3jLqFVCMxHFLUIIkoWlrIjjSSESgK7YzftIXDTS46r3exYcng4iyXlBJLy1lOXMMNWxi~BiF7-uLKcmX3WVrRNdiytPEMf2mRrnmFBh1-5NEJruMYpTe8kr9hHzBldUKicrOW5-KAgrVlf3lyg9CoufVvdmyeYYe0~UJUSqc6dZzKsJeioqaHn-4Zp9VWA__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":237,"name":"Cognitive Science","url":"https://www.academia.edu/Documents/in/Cognitive_Science"},{"id":1239755,"name":"Neurosciences","url":"https://www.academia.edu/Documents/in/Neurosciences"}],"urls":[{"id":11426412,"url":"https://www.frontiersin.org/article/10.3389/fnins.2018.00636/full"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155555"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain"><img alt="Research paper thumbnail of Epigenetic profiles associated with major depression in the human brain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain">Epigenetic profiles associated with major depression in the human brain</a></div><div class="wp-workCard_item"><span>Psychiatry Research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155555"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155555"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155555; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155555]").text(description); $(".js-view-count[data-work-id=53155555]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155555; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155555']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155555, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155555]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155555,"title":"Epigenetic profiles associated with major depression in the human brain","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Psychiatry Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155555/Epigenetic_profiles_associated_with_major_depression_in_the_human_brain","translated_internal_url":"","created_at":"2021-09-21T13:01:29.794-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Epigenetic_profiles_associated_with_major_depression_in_the_human_brain","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":635,"name":"Psychiatry","url":"https://www.academia.edu/Documents/in/Psychiatry"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426411,"url":"https://api.elsevier.com/content/article/PII:S0165178117311861?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155554"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways"><img alt="Research paper thumbnail of Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways" class="work-thumbnail" src="https://attachments.academia-assets.com/70075906/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways">Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD fol...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson&#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="717cc0ae1ff05e10f9d91e3a25efaeaf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075906,"asset_id":53155554,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155554"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155554"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155554; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155554]").text(description); $(".js-view-count[data-work-id=53155554]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155554; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155554']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155554, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "717cc0ae1ff05e10f9d91e3a25efaeaf" } } $('.js-work-strip[data-work-id=53155554]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155554,"title":"Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways","translated_title":"","metadata":{"abstract":"Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson\u0026#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...","publisher":"Cold Spring Harbor Laboratory"},"translated_abstract":"Post-traumatic stress disorder (PTSD) is a common and debilitating disorder. The risk of PTSD following trauma is heritable, but robust common variants have yet to be identified by genome-wide association studies (GWAS). We have collected a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls. We first demonstrate significant genetic correlations across 60 PTSD cohorts to evaluate the comparability of these phenotypically heterogeneous studies. In this largest GWAS meta-analysis of PTSD to date we identify a total of 6 genome-wide significant loci, 4 in European and 2 in African-ancestry analyses. Follow-up analyses incorporated local ancestry and sex-specific effects, and functional studies. Along with other novel genes, a non-coding RNA (ncRNA) and a Parkinson\u0026#39;s Disease gene, PARK2, were associated with PTSD. Consistent with previous reports, SNP-based heritability estimates for PTSD range between 10-20%. Despite a significant shared liability between PTSD...","internal_url":"https://www.academia.edu/53155554/Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways","translated_internal_url":"","created_at":"2021-09-21T13:01:29.611-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075906/thumbnails/1.jpg","file_name":"458562.full.pdf","download_url":"https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Largest_genome_wide_association_study_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075906/458562.full-libre.pdf?1632254713=\u0026response-content-disposition=attachment%3B+filename%3DLargest_genome_wide_association_study_fo.pdf\u0026Expires=1732780602\u0026Signature=BBkumFuqs12X4LZVeqzmy6yNzr9gKxroWEcNczCdZWMQzdh0Bsg0ICb5aa9u2Mk1vxtKAFBh6duKPjabk3wNm8F0etpg8nE8qg1EYNNBPZzMSueiKW-9QGnepXrLi~i8VYWpqB1BHcnZ1kUsQ~kWsEYnoECbs2zNHukUyi7CjJGq43vNhlje9Xcl5UxRAuDMItLhvuZX6MlPrP02jeQ2c8D0axShz3s7OdkG~7JIJAXqrZ39aopZef7TEoMjkel~tsBgk0hTShOUdFNiclUKikhiCRBbM27nkj9asEpY19uXycZ7NHR-sLzjsaHgc-51GDtjqAVEN~3-HbSQV6h5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Largest_genome_wide_association_study_for_PTSD_identifies_genetic_risk_loci_in_European_and_African_ancestries_and_implicates_novel_biological_pathways","translated_slug":"","page_count":78,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075906,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075906/thumbnails/1.jpg","file_name":"458562.full.pdf","download_url":"https://www.academia.edu/attachments/70075906/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Largest_genome_wide_association_study_fo.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075906/458562.full-libre.pdf?1632254713=\u0026response-content-disposition=attachment%3B+filename%3DLargest_genome_wide_association_study_fo.pdf\u0026Expires=1732780602\u0026Signature=BBkumFuqs12X4LZVeqzmy6yNzr9gKxroWEcNczCdZWMQzdh0Bsg0ICb5aa9u2Mk1vxtKAFBh6duKPjabk3wNm8F0etpg8nE8qg1EYNNBPZzMSueiKW-9QGnepXrLi~i8VYWpqB1BHcnZ1kUsQ~kWsEYnoECbs2zNHukUyi7CjJGq43vNhlje9Xcl5UxRAuDMItLhvuZX6MlPrP02jeQ2c8D0axShz3s7OdkG~7JIJAXqrZ39aopZef7TEoMjkel~tsBgk0hTShOUdFNiclUKikhiCRBbM27nkj9asEpY19uXycZ7NHR-sLzjsaHgc-51GDtjqAVEN~3-HbSQV6h5rQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[{"id":11426410,"url":"https://syndication.highwire.org/content/doi/10.1101/458562"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155553"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression"><img alt="Research paper thumbnail of 501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression">501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression</a></div><div class="wp-workCard_item"><span>Biological Psychiatry</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155553"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155553"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155553; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155553]").text(description); $(".js-view-count[data-work-id=53155553]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155553; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155553']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155553, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155553]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155553,"title":"501. Epigenetic Modifications of Stress-Relevant Genes as Peripheral Biomarkers of Treatment-Resistant Depression","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Biological Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155553/501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression","translated_internal_url":"","created_at":"2021-09-21T13:01:29.403-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"501_Epigenetic_Modifications_of_Stress_Relevant_Genes_as_Peripheral_Biomarkers_of_Treatment_Resistant_Depression","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":47884,"name":"Biological Sciences","url":"https://www.academia.edu/Documents/in/Biological_Sciences"},{"id":49600,"name":"Biological Psychiatry","url":"https://www.academia.edu/Documents/in/Biological_Psychiatry"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426408,"url":"http://api.elsevier.com/content/article/PII:S0006322317312313?httpAccept=text/plain"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155551"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study">FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item"><span>Journal of Psychiatric Research</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155551"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155551"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155551; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155551]").text(description); $(".js-view-count[data-work-id=53155551]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155551; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155551']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155551, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155551]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155551,"title":"FKBP5 DNA Methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_name":"Journal of Psychiatric Research"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155551/FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2021-09-21T13:01:29.217-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"FKBP5_DNA_Methylation_does_not_mediate_the_association_between_childhood_maltreatment_and_depression_symptom_severity_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":621186,"name":"Psychiatric","url":"https://www.academia.edu/Documents/in/Psychiatric"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":11426407,"url":"http://api.elsevier.com/content/article/PII:S0022395617303126?httpAccept=text/xml"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155550"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression"><img alt="Research paper thumbnail of Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression">Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression</a></div><div class="wp-workCard_item"><span>Journal of Affective Disorders</span><span>, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155550"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155550"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155550; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155550]").text(description); $(".js-view-count[data-work-id=53155550]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155550; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155550']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155550, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155550]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155550,"title":"Glucocorticoid Receptor DNA methylation, Childhood Maltreatment and Major Depression","translated_title":"","metadata":{"publisher":"Elsevier BV","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Journal of Affective Disorders"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155550/Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression","translated_internal_url":"","created_at":"2021-09-21T13:01:29.107-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Glucocorticoid_Receptor_DNA_methylation_Childhood_Maltreatment_and_Major_Depression","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":67516,"name":"Affective Disorders","url":"https://www.academia.edu/Documents/in/Affective_Disorders"},{"id":2922956,"name":"Psychology and Cognitive Sciences","url":"https://www.academia.edu/Documents/in/Psychology_and_Cognitive_Sciences"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155549"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression"><img alt="Research paper thumbnail of Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression" class="work-thumbnail" src="https://attachments.academia-assets.com/70075905/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression">Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression</a></div><div class="wp-workCard_item"><span>Nature communications</span><span>, Jan 3, 2016</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2283a7350c15be0582884ac1f3f8f1af" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075905,"asset_id":53155549,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155549"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155549"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155549; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155549]").text(description); $(".js-view-count[data-work-id=53155549]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155549; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155549']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155549, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2283a7350c15be0582884ac1f3f8f1af" } } $('.js-work-strip[data-work-id=53155549]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155549,"title":"Corrigendum: DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression","translated_title":"","metadata":{"grobid_abstract":"The original version of this Article contained an error in the spelling of the author Jennifer S. Stevens, which was incorrectly given as Jennifer J. Stevens. Furthermore, in Fig. 5, the titles for panels a and b were inadvertently switched. Both of these errors have now been corrected in the PDF and HTML versions of the Article.","publication_date":{"day":3,"month":1,"year":2016,"errors":{}},"publication_name":"Nature communications","grobid_abstract_attachment_id":70075905},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155549/Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_internal_url":"","created_at":"2021-09-21T13:01:28.994-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075905/thumbnails/1.jpg","file_name":"pmc4782056.pdf","download_url":"https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Corrigendum_DICER1_and_microRNA_regulati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075905/pmc4782056-libre.pdf?1632254704=\u0026response-content-disposition=attachment%3B+filename%3DCorrigendum_DICER1_and_microRNA_regulati.pdf\u0026Expires=1732780602\u0026Signature=Sig4Pb2nQUgmM4nFW2vTMvz1FcR~k83cyajZyUpkGCX9EtjW7~n1OnPfWTDYpwYYUueJC-sNEWvs~SDBGYB5Uo01w05QrNY8P0px1OUR1MrmMICCNt56K3YsuhpzUM9QT49AT6SeVvG2wObrPJOKJBq6aWQT2T-jrqDj7c-Hl0muLDezEtDncgzxwjtJvYuvEEOQPnralR8DJ0HS1LrASf28Xh5yumgzzx756Ovxb6UoxdcodhfzqKrfKfP8aQvVbUChLi7BV0gEUB06Tbw4hhd8vCGu9ZvdOupepY9JXeyamiNTh~CC15zxM45js1hEOC~-MlX9DCYwHp-aKrXe0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Corrigendum_DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_slug":"","page_count":1,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075905,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075905/thumbnails/1.jpg","file_name":"pmc4782056.pdf","download_url":"https://www.academia.edu/attachments/70075905/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Corrigendum_DICER1_and_microRNA_regulati.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075905/pmc4782056-libre.pdf?1632254704=\u0026response-content-disposition=attachment%3B+filename%3DCorrigendum_DICER1_and_microRNA_regulati.pdf\u0026Expires=1732780602\u0026Signature=Sig4Pb2nQUgmM4nFW2vTMvz1FcR~k83cyajZyUpkGCX9EtjW7~n1OnPfWTDYpwYYUueJC-sNEWvs~SDBGYB5Uo01w05QrNY8P0px1OUR1MrmMICCNt56K3YsuhpzUM9QT49AT6SeVvG2wObrPJOKJBq6aWQT2T-jrqDj7c-Hl0muLDezEtDncgzxwjtJvYuvEEOQPnralR8DJ0HS1LrASf28Xh5yumgzzx756Ovxb6UoxdcodhfzqKrfKfP8aQvVbUChLi7BV0gEUB06Tbw4hhd8vCGu9ZvdOupepY9JXeyamiNTh~CC15zxM45js1hEOC~-MlX9DCYwHp-aKrXe0g__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155548"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression"><img alt="Research paper thumbnail of DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression" class="work-thumbnail" src="https://attachments.academia-assets.com/70075910/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression">DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression</a></div><div class="wp-workCard_item"><span>Nature communications</span><span>, Jan 3, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3&#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD&Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD&Dep reveals miRNAs to be significantly downregulated...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="1a05b0b8af27052202022aa6ffeffdcf" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075910,"asset_id":53155548,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155548"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155548"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155548; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155548]").text(description); $(".js-view-count[data-work-id=53155548]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155548; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155548']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155548, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "1a05b0b8af27052202022aa6ffeffdcf" } } $('.js-work-strip[data-work-id=53155548]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155548,"title":"DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression","translated_title":"","metadata":{"abstract":"DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD\u0026Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3\u0026#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD\u0026Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD\u0026Dep reveals miRNAs to be significantly downregulated...","publication_date":{"day":3,"month":1,"year":2015,"errors":{}},"publication_name":"Nature communications"},"translated_abstract":"DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD\u0026Dep), we find that blood DICER1 expression is significantly reduced in cases versus controls, and replicate this in two independent cohorts. Our follow-up studies find that lower blood DICER1 expression is significantly associated with increased amygdala activation to fearful stimuli, a neural correlate for PTSD. Additionally, a genetic variant in the 3\u0026#39; un-translated region of DICER1, rs10144436, is significantly associated with DICER1 expression and with PTSD\u0026Dep, and the latter is replicated in an independent cohort. Furthermore, genome-wide differential expression survey of miRNAs in blood in PTSD\u0026Dep reveals miRNAs to be significantly downregulated...","internal_url":"https://www.academia.edu/53155548/DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_internal_url":"","created_at":"2021-09-21T13:01:28.885-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075910/thumbnails/1.jpg","file_name":"4686835.pdf","download_url":"https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DICER1_and_microRNA_regulation_in_post_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075910/4686835-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DDICER1_and_microRNA_regulation_in_post_t.pdf\u0026Expires=1732780602\u0026Signature=GGSAP2eCmziDzFvoiU7sBZ3rq3zdBBybH9ZClu-vV-5-jT5L~CDsZcahQiURNHkznl17YsFcCois-LtRZ-roOq1PgjFH5~d4SYOqoXAMUH0hqJ~txQETo4irmiREYqzVMWYKtsKUAi-7jGsCsCd4BOoaYt88xRZswbCNCKNVPKmBVPtiA~OeVCKlgRBKKnEQ2~fpiLESDGKC3BpBLrS59i9Tbi9TH4r20Qt8axqRgP4aeGN8PMLilt8MRXQld8pmIQfeK-0BToxPlUjNtUAYzJ-NUoeztrL2ycPyc7zrrVsU67-Zmd-OTB-IeizSaaSbjBCj7~4l0VI34lpLmBkUMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"DICER1_and_microRNA_regulation_in_post_traumatic_stress_disorder_with_comorbid_depression","translated_slug":"","page_count":13,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075910,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075910/thumbnails/1.jpg","file_name":"4686835.pdf","download_url":"https://www.academia.edu/attachments/70075910/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"DICER1_and_microRNA_regulation_in_post_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075910/4686835-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DDICER1_and_microRNA_regulation_in_post_t.pdf\u0026Expires=1732780602\u0026Signature=GGSAP2eCmziDzFvoiU7sBZ3rq3zdBBybH9ZClu-vV-5-jT5L~CDsZcahQiURNHkznl17YsFcCois-LtRZ-roOq1PgjFH5~d4SYOqoXAMUH0hqJ~txQETo4irmiREYqzVMWYKtsKUAi-7jGsCsCd4BOoaYt88xRZswbCNCKNVPKmBVPtiA~OeVCKlgRBKKnEQ2~fpiLESDGKC3BpBLrS59i9Tbi9TH4r20Qt8axqRgP4aeGN8PMLilt8MRXQld8pmIQfeK-0BToxPlUjNtUAYzJ-NUoeztrL2ycPyc7zrrVsU67-Zmd-OTB-IeizSaaSbjBCj7~4l0VI34lpLmBkUMw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3217,"name":"Depression","url":"https://www.academia.edu/Documents/in/Depression"},{"id":3931,"name":"Fear","url":"https://www.academia.edu/Documents/in/Fear"},{"id":28235,"name":"Multidisciplinary","url":"https://www.academia.edu/Documents/in/Multidisciplinary"},{"id":159962,"name":"Amygdala","url":"https://www.academia.edu/Documents/in/Amygdala"},{"id":295854,"name":"microRNAs","url":"https://www.academia.edu/Documents/in/microRNAs"},{"id":1267800,"name":"Nature Communications","url":"https://www.academia.edu/Documents/in/Nature_Communications"},{"id":1819400,"name":"Cohort Studies","url":"https://www.academia.edu/Documents/in/Cohort_Studies"},{"id":2039739,"name":"Down-Regulation","url":"https://www.academia.edu/Documents/in/Down-Regulation"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155547"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology"><img alt="Research paper thumbnail of Epidemiology, Epigenetics, and Psychopathology" class="work-thumbnail" src="https://attachments.academia-assets.com/70075907/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology">Epidemiology, Epigenetics, and Psychopathology</a></div><div class="wp-workCard_item"><span>Medical Epigenetics</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f571daa5413810bec8e9ceaf0478227" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075907,"asset_id":53155547,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155547"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155547"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155547; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155547]").text(description); $(".js-view-count[data-work-id=53155547]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155547; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155547']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155547, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f571daa5413810bec8e9ceaf0478227" } } $('.js-work-strip[data-work-id=53155547]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155547,"title":"Epidemiology, Epigenetics, and Psychopathology","translated_title":"","metadata":{"publisher":"S. Karger AG","ai_title_tag":"Linking Epigenetics and Psychopathology: A Review","grobid_abstract":"The link between environmental exposure and onset of psychopathology has been well documented, yet the pathway is not fully understood. Epigenetic modifications are thought to play a role in the manifestation of disease as studies have shown that early environmental exposures can influence epigenetic variation in both humans and other animals. As a result, epigenetic epidemiology studies with a specific focus on psychopathology will play an important role in elucidating the pathway to disease onset. In order to gain a clear perspective of where this field currently stands, here we provide a brief review of important issues in epigenetic epidemiology studies of psychopathology, including causal inference, common study designs, challenges faced with current study designs, and the importance of a life course perspective. We provide the reader with relevant examples of studies when appropriate, with a particular focus on studies that have examined the epigenetic modification of DNA methylation. Implications for future research are also discussed.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Medical Epigenetics","grobid_abstract_attachment_id":70075907},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155547/Epidemiology_Epigenetics_and_Psychopathology","translated_internal_url":"","created_at":"2021-09-21T13:01:28.777-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075907/thumbnails/1.jpg","file_name":"362762.pdf","download_url":"https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epidemiology_Epigenetics_and_Psychopatho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075907/362762-libre.pdf?1632254710=\u0026response-content-disposition=attachment%3B+filename%3DEpidemiology_Epigenetics_and_Psychopatho.pdf\u0026Expires=1732780602\u0026Signature=dSMSMI8uxa~Lzn-ktp7wPtQEuTx71z2dO3oLpjBLlW2vnaAs0qIpy0RSYEolaYoeOxCDIAyfkyYruyAlDYRq3lGRKSeIY-pB-wAkn8WZw0zdk1RFA1JvgseXR02NijD5gZZVNosaAc2WPNYh6pDVQQ~TvaWayWZ21FHQHXazJWHxVgwogf8p-xNRiTi6wf3ZRv5huHevCb~MI2XOmblS5B1grhJHEic3Qmvv7dVZa7wEgA3hBLc7L0CirIT7OUs1OaRHm0-E28EtTPFwVyMh-IuT6SP1cS8OtnPXyXhCFld2tmDyJBOf93sCwukJB6fcNpIHSnzPVN-3KkvK0sHSIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Epidemiology_Epigenetics_and_Psychopathology","translated_slug":"","page_count":11,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075907,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075907/thumbnails/1.jpg","file_name":"362762.pdf","download_url":"https://www.academia.edu/attachments/70075907/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epidemiology_Epigenetics_and_Psychopatho.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075907/362762-libre.pdf?1632254710=\u0026response-content-disposition=attachment%3B+filename%3DEpidemiology_Epigenetics_and_Psychopatho.pdf\u0026Expires=1732780602\u0026Signature=dSMSMI8uxa~Lzn-ktp7wPtQEuTx71z2dO3oLpjBLlW2vnaAs0qIpy0RSYEolaYoeOxCDIAyfkyYruyAlDYRq3lGRKSeIY-pB-wAkn8WZw0zdk1RFA1JvgseXR02NijD5gZZVNosaAc2WPNYh6pDVQQ~TvaWayWZ21FHQHXazJWHxVgwogf8p-xNRiTi6wf3ZRv5huHevCb~MI2XOmblS5B1grhJHEic3Qmvv7dVZa7wEgA3hBLc7L0CirIT7OUs1OaRHm0-E28EtTPFwVyMh-IuT6SP1cS8OtnPXyXhCFld2tmDyJBOf93sCwukJB6fcNpIHSnzPVN-3KkvK0sHSIQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155546"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses"><img alt="Research paper thumbnail of Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses" class="work-thumbnail" src="https://attachments.academia-assets.com/70075930/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses">Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses</a></div><div class="wp-workCard_item"><span>Frontiers in Psychiatry</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="da8de4b7dd635637e8f557a0fb63424e" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":70075930,"asset_id":53155546,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155546"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155546"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155546; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155546]").text(description); $(".js-view-count[data-work-id=53155546]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155546; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155546']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155546, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "da8de4b7dd635637e8f557a0fb63424e" } } $('.js-work-strip[data-work-id=53155546]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155546,"title":"Epigenetics, Stress, and Their Potential Impact on Brain Network Function: A Focus on the Schizophrenia Diatheses","translated_title":"","metadata":{"publisher":"Frontiers Media SA","grobid_abstract":"The recent sociodevelopmental cognitive model of schizophrenia/psychosis is a highly influential and compelling compendium of research findings. Here, we present logical extensions to this model incorporating ideas drawn from epigenetic mediation of psychiatric disease, and the plausible effects of epigenetics on the emergence of brain network function and dysfunction in adolescence. We discuss how gene-environment interactions, effected by epigenetic mechanisms, might in particular mediate the stress response (itself heavily implicated in the emergence of schizophrenia). Next, we discuss the plausible relevance of this framework for adolescent genetic risk populations, a risk group characterized by vexing and difficult-to-explain heterogeneity. We then discuss how exploring relationships between epigenetics and brain network dysfunction (a strongly validated finding in risk populations) can enhance understanding of the relationship between stress, epigenetics, and functional neurobiology, and the relevance of this relationship for the eventual emergence of schizophrenia/psychosis. We suggest that these considerations can expand the impact of models such as the sociodevelopmental cognitive model, increasing their explanatory reach. Ultimately, integration of these lines of research may enhance efforts of early identification, intervention, and treatment in adolescents at-risk for schizophrenia.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Frontiers in Psychiatry","grobid_abstract_attachment_id":70075930},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155546/Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses","translated_internal_url":"","created_at":"2021-09-21T13:01:28.668-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":70075930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075930/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epigenetics_Stress_and_Their_Potential_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075930/pdf-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DEpigenetics_Stress_and_Their_Potential_I.pdf\u0026Expires=1732780602\u0026Signature=Yi6S0zNrag4H3kFw47VTh-9P65zctvZNUVMIyjSrA0GtokDhi2Fldrffmf8kWsW0-1vRn1yq-rTG3cP6-xyUgj429cMqXDDnSzBxg~b88Ck755MDmuJfMSEoK8efD-uP6rtA-Qd~wGXpLWacloc4pteLkojYRIn536~33D2DzgVr9SGwXQG2CndWxYCsBihdnEv1Z40i598ZuYdvu1ogFTkyGUmoq0ZdF3g3OPbNTNPcKkezRFnzYeGnhyWY1G9M9LmXsVSsZ3m88jAbw1C7-w8kRIxuD73AcymR0xLRc-kUBe4b89A~XrB4T2fVHgp3iADlBxqL2~DhfplmTHYm4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Epigenetics_Stress_and_Their_Potential_Impact_on_Brain_Network_Function_A_Focus_on_the_Schizophrenia_Diatheses","translated_slug":"","page_count":14,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[{"id":70075930,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/70075930/thumbnails/1.jpg","file_name":"pdf.pdf","download_url":"https://www.academia.edu/attachments/70075930/download_file?st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&st=MTczMjc3NzAwMiw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Epigenetics_Stress_and_Their_Potential_I.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/70075930/pdf-libre.pdf?1632254707=\u0026response-content-disposition=attachment%3B+filename%3DEpigenetics_Stress_and_Their_Potential_I.pdf\u0026Expires=1732780602\u0026Signature=Yi6S0zNrag4H3kFw47VTh-9P65zctvZNUVMIyjSrA0GtokDhi2Fldrffmf8kWsW0-1vRn1yq-rTG3cP6-xyUgj429cMqXDDnSzBxg~b88Ck755MDmuJfMSEoK8efD-uP6rtA-Qd~wGXpLWacloc4pteLkojYRIn536~33D2DzgVr9SGwXQG2CndWxYCsBihdnEv1Z40i598ZuYdvu1ogFTkyGUmoq0ZdF3g3OPbNTNPcKkezRFnzYeGnhyWY1G9M9LmXsVSsZ3m88jAbw1C7-w8kRIxuD73AcymR0xLRc-kUBe4b89A~XrB4T2fVHgp3iADlBxqL2~DhfplmTHYm4A__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":3227,"name":"Schizophrenia","url":"https://www.academia.edu/Documents/in/Schizophrenia"},{"id":8207,"name":"Risk","url":"https://www.academia.edu/Documents/in/Risk"},{"id":22404,"name":"Epigenetics","url":"https://www.academia.edu/Documents/in/Epigenetics"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155545"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders"><img alt="Research paper thumbnail of Epigenetic Epidemiology of Psychiatric Disorders" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders">Epigenetic Epidemiology of Psychiatric Disorders</a></div><div class="wp-workCard_item"><span>Epigenetics in Psychiatry</span><span>, 2014</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155545"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155545"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155545; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155545]").text(description); $(".js-view-count[data-work-id=53155545]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155545; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155545']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155545, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155545]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155545,"title":"Epigenetic Epidemiology of Psychiatric Disorders","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Epigenetics in Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155545/Epigenetic_Epidemiology_of_Psychiatric_Disorders","translated_internal_url":"","created_at":"2021-09-21T13:01:28.552-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Epigenetic_Epidemiology_of_Psychiatric_Disorders","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":28523,"name":"Causal Inference","url":"https://www.academia.edu/Documents/in/Causal_Inference"},{"id":82845,"name":"Effect size","url":"https://www.academia.edu/Documents/in/Effect_size"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="53155482"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study">Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item"><span>Comprehensive Psychiatry</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="53155482"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="53155482"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 53155482; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=53155482]").text(description); $(".js-view-count[data-work-id=53155482]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 53155482; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='53155482']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 53155482, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=53155482]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":53155482,"title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publication_name":"Comprehensive Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/53155482/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2021-09-21T13:00:31.329-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44194127,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44194127,"first_name":"Angela","middle_initials":null,"last_name":"Bustamante","page_name":"AngelaBustamante2","domain_name":"independent","created_at":"2016-02-29T18:54:51.552-08:00","display_name":"Angela Bustamante","url":"https://independent.academia.edu/AngelaBustamante2"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="22605646"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study"><img alt="Research paper thumbnail of Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study">Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://illinois.academia.edu/DWildman">Derek Wildman</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/AngelaBustamante2">Angela Bustamante</a></span></div><div class="wp-workCard_item"><span>Comprehensive Psychiatry</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="22605646"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="22605646"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 22605646; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=22605646]").text(description); $(".js-view-count[data-work-id=22605646]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 22605646; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='22605646']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 22605646, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=22605646]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":22605646,"title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study","translated_title":"","metadata":{"publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Comprehensive Psychiatry"},"translated_abstract":null,"internal_url":"https://www.academia.edu/22605646/Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_internal_url":"","created_at":"2016-02-29T09:10:15.336-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":44163928,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":16307631,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":null,"co_author_invite_id":254647,"email":"k***5@columbia.edu","display_order":0,"name":"Karestan Koenen","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307720,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":53487504,"co_author_invite_id":674239,"email":"a***o@email.unc.edu","display_order":4194304,"name":"Allison Aiello","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307748,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":null,"co_author_invite_id":1057349,"email":"s***a@bu.edu","display_order":6291456,"name":"Sandro Galea","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"},{"id":16307878,"work_id":22605646,"tagging_user_id":44163928,"tagged_user_id":44194127,"co_author_invite_id":3755714,"email":"a***2@illinois.edu","display_order":7340032,"name":"Angela Bustamante","title":"Childhood maltreatment is associated with epigenetic differences in hypothalamic-pituitary-adrenal (HPA) axis genes in the Detroit Neighborhood Health Study"}],"downloadable_attachments":[],"slug":"Childhood_maltreatment_is_associated_with_epigenetic_differences_in_hypothalamic_pituitary_adrenal_HPA_axis_genes_in_the_Detroit_Neighborhood_Health_Study","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":44163928,"first_name":"Derek","middle_initials":null,"last_name":"Wildman","page_name":"DWildman","domain_name":"illinois","created_at":"2016-02-29T09:09:40.545-08:00","display_name":"Derek Wildman","url":"https://illinois.academia.edu/DWildman","email":"dloyclNhc3gwZFAwT0NDUHhnUUlDbEt6NDNoSEEzOGpCM0QzcmUzWjduST0tLS84SnJOT0tBQWhVSC93eXJsQm5IM0E9PQ==--71ace2162daa8e07299388a7c743467e7ce9069f"},"attachments":[],"research_interests":[{"id":244814,"name":"Clinical Sciences","url":"https://www.academia.edu/Documents/in/Clinical_Sciences"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> </div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/google_contacts-0dfb882d836b94dbcb4a2d123d6933fc9533eda5be911641f20b4eb428429600.js"], function() { // from javascript_helper.rb $('.js-google-connect-button').click(function(e) { e.preventDefault(); GoogleContacts.authorize_and_show_contacts(); Aedu.Dismissibles.recordClickthrough("WowProfileImportContactsPrompt"); }); $('.js-update-biography-button').click(function(e) { e.preventDefault(); Aedu.Dismissibles.recordClickthrough("UpdateUserBiographyPrompt"); $.ajax({ url: $r.api_v0_profiles_update_about_path({ subdomain_param: 'api', about: "", }), type: 'PUT', success: function(response) { location.reload(); } }); }); $('.js-work-creator-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_document_path({ source: encodeURIComponent(""), }); }); $('.js-video-upload-button').click(function (e) { e.preventDefault(); window.location = $r.upload_funnel_video_path({ source: encodeURIComponent(""), }); }); $('.js-do-this-later-button').click(function() { $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("WowProfileImportContactsPrompt"); }); $('.js-update-biography-do-this-later-button').click(function(){ $(this).closest('.js-profile-nag-panel').remove(); Aedu.Dismissibles.recordDismissal("UpdateUserBiographyPrompt"); }); $('.wow-profile-mentions-upsell--close').click(function(){ $('.wow-profile-mentions-upsell--panel').hide(); Aedu.Dismissibles.recordDismissal("WowProfileMentionsUpsell"); }); $('.wow-profile-mentions-upsell--button').click(function(){ Aedu.Dismissibles.recordClickthrough("WowProfileMentionsUpsell"); }); new WowProfile.SocialRedesignUserWorks({ initialWorksOffset: 20, allWorksOffset: 20, maxSections: 1 }) }); </script> </div></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile_edit-5ea339ee107c863779f560dd7275595239fed73f1a13d279d2b599a28c0ecd33.js","https://a.academia-assets.com/assets/add_coauthor-22174b608f9cb871d03443cafa7feac496fb50d7df2d66a53f5ee3c04ba67f53.js","https://a.academia-assets.com/assets/tab-dcac0130902f0cc2d8cb403714dd47454f11fc6fb0e99ae6a0827b06613abc20.js","https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js"], function() { // from javascript_helper.rb window.ae = window.ae || {}; window.ae.WowProfile = window.ae.WowProfile || {}; if(Aedu.User.current && Aedu.User.current.id === $viewedUser.id) { window.ae.WowProfile.current_user_edit = {}; new WowProfileEdit.EditUploadView({ el: '.js-edit-upload-button-wrapper', model: window.$current_user, }); new AddCoauthor.AddCoauthorsController(); } var userInfoView = new WowProfile.SocialRedesignUserInfo({ recaptcha_key: "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB" }); WowProfile.router = new WowProfile.Router({ userInfoView: userInfoView }); Backbone.history.start({ pushState: true, root: "/" + $viewedUser.page_name }); new WowProfile.UserWorksNav() }); </script> </div> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "e323944ac250825f9db2627fed463d4a2528c3539cf1bfdcabfa747c46359c64", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="5rdQe75BCANeqgTk2ImqTyRdbgRSgFMu90iMaQ0LPa+NBg9/+HaVRYy3cOAroizcdPv57G9wm73gI5Q4ferb0Q==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://independent.academia.edu/AngelaBustamante2" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="F4a+RPiH1CmjU5qoTNk7KvbD/cZGu+lUmfGr2Wl06Tl8N+FAvrBJb3FO7qy/8r25pmVqLntLIceOmrOIGZUPRw==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><script src="https://recaptcha.net/recaptcha/api.js" async defer></script> <script> var invisibleRecaptchaSubmit = function () { var closestForm = function (ele) { var curEle = ele.parentNode; while (curEle.nodeName !== 'FORM' && curEle.nodeName !== 'BODY'){ curEle = curEle.parentNode; } return curEle.nodeName === 'FORM' ? curEle : null }; var eles = document.getElementsByClassName('g-recaptcha'); if (eles.length > 0) { var form = closestForm(eles[0]); if (form) { form.submit(); } } }; </script> <input type="submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" data-callback="invisibleRecaptchaSubmit" class="g-recaptcha btn btn-primary btn-block" value="Email me a link" value=""/> </form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div class="bootstrap" id="footer"><div class="footer-content clearfix text-center padding-top-7x" style="width:100%;"><ul class="footer-links-secondary footer-links-wide list-inline margin-bottom-1x"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a rel="nofollow" href="https://medium.com/academia">Blog</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/journals">Academia.edu Journals</a></li><li><a rel="nofollow" href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a rel="nofollow" href="https://support.academia.edu/"><svg style="width: 12px; height: 12px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer-links-tertiary list-inline margin-bottom-1x"><li class="small">Find new research papers in:</li><li class="small"><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li class="small"><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul></div></div><div class="DesignSystem" id="credit" style="width:100%;"><ul class="u-pl0x footer-links-legal list-inline"><li><a rel="nofollow" href="https://www.academia.edu/terms">Terms</a></li><li><a rel="nofollow" href="https://www.academia.edu/privacy">Privacy</a></li><li><a rel="nofollow" href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2024</li></ul></div><script> //<![CDATA[ window.detect_gmtoffset = true; window.Academia && window.Academia.set_gmtoffset && Academia.set_gmtoffset('/gmtoffset'); //]]> </script> <div id='overlay_background'></div> <div id='bootstrap-modal-container' class='bootstrap'></div> <div id='ds-modal-container' class='bootstrap DesignSystem'></div> <div id='full-screen-modal'></div> </div> </body> </html>