The Role of Chemokine Family, CXCL-10 Urine as a Marker Diagnosis of Active Lung Tuberculosis in HIV/AIDS Patients

<!DOCTYPE html> <html lang="en" dir="ltr"> <head>  <script async src="https://www.googletagmanager.com/gtag/js?id=G-P63WKM1TM1"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-P63WKM1TM1'); </script>  <script type="text/javascript" > (function(m,e,t,r,i,k,a){m[i]=m[i]||function(){(m[i].a=m[i].a||[]).push(arguments)}; m[i].l=1*new Date(); for (var j = 0; j < document.scripts.length; j++) {if (document.scripts[j].src === r) { return; }} k=e.createElement(t),a=e.getElementsByTagName(t)[0],k.async=1,k.src=r,a.parentNode.insertBefore(k,a)}) (window, document, "script", "https://mc.yandex.ru/metrika/tag.js", "ym"); ym(55165297, "init", { clickmap:false, trackLinks:true, accurateTrackBounce:true, webvisor:false }); </script> <noscript><div><img src="https://mc.yandex.ru/watch/55165297" style="position:absolute; left:-9999px;" alt="" /></div></noscript>    <title>The Role of Chemokine Family, CXCL-10 Urine as a Marker Diagnosis of Active Lung Tuberculosis in HIV/AIDS Patients</title> <meta name="description" content="The Role of Chemokine Family, CXCL-10 Urine as a Marker Diagnosis of Active Lung Tuberculosis in HIV/AIDS Patients"> <meta name="keywords" content="Chemokine, IP-10 urine, HIV/AIDS, Tuberculosis. "> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <meta name="citation_title" content="The Role of Chemokine Family, CXCL-10 Urine as a Marker Diagnosis of Active Lung Tuberculosis in HIV/AIDS Patients"> <meta name="citation_author" content="Dwitya Elvira"> <meta name="citation_author" content="Raveinal Masri"> <meta name="citation_author" content="Rohayat Bilmahdi"> <meta name="citation_publication_date" content="2017/01/03"> <meta name="citation_journal_title" content="International Journal of Biomedical and Biological Engineering"> <meta name="citation_volume" content="11"> <meta name="citation_issue" content="3"> <meta name="citation_firstpage" content="86"> <meta name="citation_lastpage" content="89"> <meta name="citation_pdf_url" content="https://publications.waset.org/10006439/pdf"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link 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Bilmahdi</a> </p> <p class="card-text"><strong>Abstract:</strong></p> <p>Human Immunodeficiency Virus (HIV) pandemic increased significantly worldwide. The rise in cases of HIV/AIDS was also followed by an increase in the incidence of opportunistic infection, with tuberculosis being the most opportunistic infection found in HIV/AIDS and the main cause of mortality in HIV/AIDS patients. Diagnosis of tuberculosis in HIV/AIDS patients is often difficult because of the uncommon symptom in HIV/AIDS patients compared to those without the disease. Thus, diagnostic tools are required that are more effective and efficient to diagnose tuberculosis in HIV/AIDS. CXCL-10/IP-10 is a chemokine that binds to the CXCR3 receptor found in HIV/AIDS patients with a weakened immune system. Tuberculosis infection in HIV/AIDS activates chemokine IP-10 in urine, which is used as a marker for diagnosis of infection. The aim of this study was to prove whether IP-10 urine can be a biomarker diagnosis of active lung tuberculosis in HIV-AIDS patients. Design of this study is a cross sectional study involving HIV/AIDS patients with lung tuberculosis as the subject of this study. Forty-seven HIV/AIDS patients with tuberculosis based on clinical and biochemical laboratory were asked to collect urine samples and IP-10/CXCL-10 urine being measured using ELISA method with 18 healthy human urine samples as control. Forty-seven patients diagnosed as HIV/AIDS were included as a subject of this study. HIV/AIDS were more common in male than in women with the percentage in male 85.1% vs. 14.5% of women. In this study, most diagnosed patients were aged 31-40 years old, followed by those 21-30 years, and > 40 years old, with one case diagnosed at age less than 20 years of age. From the result of the urine IP-10 using ELISA method, there was significant increase of the mean value of IP-10 urine in patients with TB-HIV/AIDS co-infection compared to the healthy control with mean 61.05 pg/mL ± 78.01 pg/mL vs. mean 17.2 pg/mL. Based on this research, there was significant increase of urine IP-10/CXCL-10 in active lung tuberculosis with HIV/AIDS compared to the healthy control. From this finding, it is necessary to conduct further research into whether urine IP-10/CXCL-10 plays a significant role in TB-HIV/AIDS co-infection, which can also be used as a biomarker in the early diagnosis of TB-HIV.</p> <iframe src="https://publications.waset.org/10006439.pdf" style="width:100%; height:400px;" frameborder="0"></iframe> <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/search?q=Chemokine" title="Chemokine">Chemokine</a>, <a href="https://publications.waset.org/search?q=IP-10%20urine" title=" IP-10 urine"> IP-10 urine</a>, <a href="https://publications.waset.org/search?q=HIV%2FAIDS" title=" HIV/AIDS"> HIV/AIDS</a>, <a href="https://publications.waset.org/search?q=Tuberculosis." title=" Tuberculosis. "> Tuberculosis. </a> </p> <p class="card-text"><strong>Digital Object Identifier (DOI):</strong> <a href="https://doi.org/10.5281/zenodo.1128889" target="_blank">doi.org/10.5281/zenodo.1128889</a> </p> <a href="https://publications.waset.org/10006439/the-role-of-chemokine-family-cxcl-10-urine-as-a-marker-diagnosis-of-active-lung-tuberculosis-in-hivaids-patients" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/10006439/apa" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">APA</a> <a href="https://publications.waset.org/10006439/bibtex" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">BibTeX</a> <a href="https://publications.waset.org/10006439/chicago" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Chicago</a> <a href="https://publications.waset.org/10006439/endnote" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">EndNote</a> <a href="https://publications.waset.org/10006439/harvard" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">Harvard</a> <a href="https://publications.waset.org/10006439/json" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">JSON</a> <a href="https://publications.waset.org/10006439/mla" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">MLA</a> <a href="https://publications.waset.org/10006439/ris" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">RIS</a> <a href="https://publications.waset.org/10006439/xml" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">XML</a> <a href="https://publications.waset.org/10006439/iso690" target="_blank" rel="nofollow" class="btn btn-primary btn-sm">ISO 690</a> <a href="https://publications.waset.org/10006439.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">1108</span> </span> <p class="card-text"><strong>References:</strong></p> <br>[1] Cahyadi E. Hubungan Stadium Klinis dengan Jumlah CD4 Penderita HIV di BLUD RSUZA Banda Aceh. 2014. <br>[2] Cannas A, Calvo L, Chiacchio T, Cuzzi G, Vanini V, et al. IP10 detection in urine is associated with lung diseases. BMC Infectious Diseases 2010;10(333):1-8. <br>[3] Contreas G, Donnachie E, Murphy JR, Heresy GP. Elevated IP10 associates with CD8 cell activation and low CD4 in perinatally acquired HIV infection. OFID. 2014;1(1):S427. <br>[4] Directorate General of Communicable Disease Control and Environmental Health of Ministry of Health Indonesia. Statistical Report Case of HIV-AIDS in Indonesia. 2014. <br>[5] Directorate General of Communicable Disease Control and Environmental Health of Ministry of Health Indonesia. Technical Guidelines for Clinical Management of TB-HIV Co-infection. 2012. <br>[6] WHO. Global Tuberculosis Report 2012. <br>[7] Gopalan N, Chandrasekaran P, Swaminathan S, Tripathy S. Current trends and intricacies in the management of HIV-associated pulmonary tuberculosis. AIDS Res Ther. 2016;13(34):1-19. <br>[8] Hong JY, Lee HJ, Kim SY, Chung KS, Kim EY, et al. Efficacy of IP10 as a biomarker for monitoring tuberculosis treatment. J Infect. 2014;68(3):252-8. <br>[9] Latorre I, Diaz J, Mialdea I, Serra-Vidal M, Altet N, et al. IP10 is an accurate biomarker for the diagnosis of tuberculosis in children. J Infect. 2014;69(6):590-9. <br>[10] Murray C, Ortoblad K, Guinovart C, Lim S, Wolock T, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384(9947):1005-1070. <br>[11] Peter J, Green C, Hoelscher M, Mwaba P, Zumla A, et al. Urine for the diagnosis of tuberculosis: current approaches, clinical applicability and new developments. Curr Opin Pulm Med. 2010;16(3):262-70. <br>[12] Ruhwald M, Aabye MG, Ravn P. IP10 release assays in the diagnosis of tuberculosis infection: current status and future directions. Expert Rev Mol Diagn. 2012;12(2):175-87. <br>[13] Petrone L, Cannas A, Aloi F, Nsubuga M, Sserumkuma J et al. Blood or urine IP10 cannot discriminate between active tuberculosis and respiratory diseases different from children. Biomed Research International. 2015;1-11. <br>[14] Wergeland I, Pullar N, Assmus J, Ueland T, Tonby K, et al. IP10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy. 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The Role of Chemokine Family, CXCL-10 Urine as a Marker Diagnosis of Active Lung Tuberculosis in HIV/AIDS Patients