<?xml version="1.0" encoding="UTF-8"?> <feed xmlns="http://www.w3.org/2005/Atom" xmlns:dc="http://purl.org/dc/elements/1.1/"> <title>Kyoto University Research Information Repository</title> <link rel="alternate" href="https://repository.kulib.kyoto-u.ac.jp:443/dspace" /> <subtitle>DSpaceはデジタル研究資料を収集・格納・索引・保存・配布するシステムです。</subtitle> <id>https://repository.kulib.kyoto-u.ac.jp:443/dspace</id> <updated>2024-12-01T06:07:12Z</updated> <dc:date>2024-12-01T06:07:12Z</dc:date> <entry> <title>Quantitative analysis of air-oxidation reactions of thiolate-protected gold nanoclusters</title> <link rel="alternate" href="http://hdl.handle.net/2433/290632" /> <author> <name>Suzuki, Wataru</name> </author> <author> <name>Takahata, Ryo</name> </author> <author> <name>Mizuhata, Yoshiyuki</name> </author> <author> <name>Tokitoh, Norihiro</name> </author> <author> <name>Xue, Songlin</name> </author> <author> <name>Teranishi, Toshiharu</name> </author> <id>http://hdl.handle.net/2433/290632</id> <updated>2024-11-29T09:01:37Z</updated> <published>2024-12-07T00:00:00Z</published> <summary type="text">タイトル: Quantitative analysis of air-oxidation reactions of thiolate-protected gold nanoclusters 著者: Suzuki, Wataru; Takahata, Ryo; Mizuhata, Yoshiyuki; Tokitoh, Norihiro; Xue, Songlin; Teranishi, Toshiharu 抄録: The interaction of dioxygen (O₂) with inorganic nanomaterials is one of the most essential steps to understanding the reaction mechanism of O₂-related reactions. However, quantitative analyses for O₂-binding processes and subsequent oxidation reactions on the surface are still elusive, whereas the reaction of O₂ with molecules such as transition metal complexes has been widely explored. Herein, we have quantitatively evaluated reaction processes of air-oxidation reactions of atomically precise thiolate-protected Au25 nanoclusters ([Au₂₅(SR)₁₈]−) as a model of O₂ activation by inorganic nanomaterials. Kinetic analyses on the air-oxidation reaction of [Au₂₅(SR)₁₈]− revealed a controlling factor for O₂-activation processes, which could be finely tunable by the protecting thiolate ligands.</summary> <dc:date>2024-12-07T00:00:00Z</dc:date> </entry> <entry> <title>Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study</title> <link rel="alternate" href="http://hdl.handle.net/2433/290631" /> <author> <name>Mori, Yuichiro</name> </author> <author> <name>Komura, Toshiaki</name> </author> <author> <name>Adomi, Motohiko</name> </author> <author> <name>Yagi, Ryuichiro</name> </author> <author> <name>Fukuma, Shingo</name> </author> <author> <name>Kondo, Naoki</name> </author> <author> <name>Yanagita, Motoko</name> </author> <author> <name>Duru, Kenrik, O</name> </author> <author> <name>Tuttle, R, Katherine</name> </author> <author> <name>Inoue, Kosuke</name> </author> <id>http://hdl.handle.net/2433/290631</id> <updated>2024-11-29T09:01:15Z</updated> <published>2024-10-22T00:00:00Z</published> <summary type="text">タイトル: Sodium-glucose cotransporter 2 inhibitors and cardiovascular events among patients with type 2 diabetes and low-to-normal body mass index: a nationwide cohort study 著者: Mori, Yuichiro; Komura, Toshiaki; Adomi, Motohiko; Yagi, Ryuichiro; Fukuma, Shingo; Kondo, Naoki; Yanagita, Motoko; Duru, Kenrik, O; Tuttle, R, Katherine; Inoue, Kosuke 抄録: Background: Patients with low-to-normal body mass index (BMI; &lt; 25.0 kg/m²) were underrepresented in major randomized controlled trials on sodium-glucose cotransporter 2 (SGLT2) inhibitors for type 2 diabetes. The present study aims to investigate the effectiveness of SGLT2 inhibitors for cardiovascular outcomes among patients with type 2 diabetes and low-to-normal BMI, using finer stratification than previous trials. Methods: This cohort study with a target trial emulation framework was conducted using insurance claims and health screening records of more than 30 million working-age citizens in Japan acquired from April 1, 2015 to March 31, 2022. 139, 783 new users of SGLT2 inhibitors matched to 139, 783 users of dipeptidyl protease (DPP) 4 inhibitors with stratification by BMI category (&lt; 20.0, 20.0–22.4, 22.5–24.9, 25.0–29.9, 30.0–34.9, and 35.0 ≤ kg/m²). The primary outcome was a composite of all-cause death, myocardial infarction, stroke, or heart failure. Secondary outcomes were the components of the primary outcome. Cox proportional hazard models were used to compare SGLT2 inhibitors with DPP4 inhibitors in the whole population and subgroups defined by the BMI category. Results: Among participants, 17.3% (n = 48, 377) were female and 31.0% (n = 86, 536) had low-to-normal BMI (&lt; 20.0 kg/m², 1.9% [n = 5, 350]; 20.0–22.4 kg/m², 8.5% [n = 23, 818]; and 22.5–24.9 kg/m2, 20.5% [n = 57, 368]). Over a median follow-up of 24 months, the primary outcome occurred in 2.9% (n = 8, 165) of participants. SGLT2 inhibitors were associated with a decreased incidence of the primary outcome in the whole population (HR [95%CI] = 0.92 [0.89 to 0.96]), but not in patients with low-to-normal BMI (&lt; 20.0 kg/m², HR [95%CI] = 1.08 [0.80 to 1.46]; 20.0–22.4 kg/m2, HR [95%CI] = 1.04 [0.90 to 1.20]; and 22.5–24.9 kg/m², HR [95%CI] = 0.92 [0.84 to 1.01]). Conclusions: The protective effect of SGLT2 inhibitors on cardiovascular events among patients with type 2 diabetes appeared to decrease with lower BMI and was not significant among patients with low-to-normal BMI (&lt; 25.0 kg/m²). These findings suggest the importance of considering BMI when initiating SGLT2 inhibitors. 記述: 糖尿病におけるSGLT2阻害薬の効果がBMIによって異なることが明らかに --臨床試験の知見を、ビッグデータで幅広い患者層へ拡張 --.　京都大学プレスリリース. 2024-10-30.</summary> <dc:date>2024-10-22T00:00:00Z</dc:date> </entry> <entry> <title>Impacts of building modifications on the turbulent flow and heat transfer in urban surface boundary layers</title> <link rel="alternate" href="http://hdl.handle.net/2433/290630" /> <author> <name>Tanji, Seika</name> </author> <author> <name>Takemi, Tetsuya</name> </author> <author> <name>Duan, Guangdong</name> </author> <id>http://hdl.handle.net/2433/290630</id> <updated>2024-11-29T09:01:51Z</updated> <published>2024-11-01T00:00:00Z</published> <summary type="text">タイトル: Impacts of building modifications on the turbulent flow and heat transfer in urban surface boundary layers 著者: Tanji, Seika; Takemi, Tetsuya; Duan, Guangdong 抄録: This study examines turbulent airflow and upward heat transport in real urban environments using a building-resolving large-eddy simulation model to understand the characteristics of turbulent airflow and upward heat transport when geometrical distributions of buildings are modified. The target areas were two real urban districts within Osaka City, Japan, having different morphological features. In the numerical experiments, the initial condition was set to a neutral condition in which temperature is uniformly distributed vertically, and buildings emitted heat at a constant rate. The results in the two districts indicated that the features of turbulence and heat transport distinctly differed with different building arrangement. Specifically, taller buildings significantly decelerated airflows and induced warming behind buildings. More high-rise buildings (which resulted in a larger building variability) in a district with a larger building density caused a large heat flux and warming at higher levels. The sensitivity experiments in which a density and height variability of buildings were modified showed that a building density at higher levels and a building height variability significantly influenced warming at upper levels. An increased building height variability weakened wind speed and disturbed horizontal heat advection, whereas a large building density caused numerous heat sources.</summary> <dc:date>2024-11-01T00:00:00Z</dc:date> </entry> <entry> <title>Sequential formation of supermassive stars and heavy seed BHs through the interplay of cosmological cold accretion and stellar radiative feedback</title> <link rel="alternate" href="http://hdl.handle.net/2433/290628" /> <author> <name>Kiyuna, Masaki</name> </author> <author> <name>Hosokawa, Takashi</name> </author> <author> <name>Chon, Sunmyon</name> </author> <id>http://hdl.handle.net/2433/290628</id> <updated>2024-11-29T09:01:00Z</updated> <published>2024-11-01T00:00:00Z</published> <summary type="text">タイトル: Sequential formation of supermassive stars and heavy seed BHs through the interplay of cosmological cold accretion and stellar radiative feedback 著者: Kiyuna, Masaki; Hosokawa, Takashi; Chon, Sunmyon 抄録: Supermassive stars (SMSs) and heavy seed black holes, as their remnants, are promising candidates for supermassive black hole (SMBH) progenitors, especially for ones observed in the early universe z≃8.5-10 by recent JWST observations. Expected cradles of SMSs are the atomic cooling haloes (Mₕₐₗₒ≃10⁷M[⊙]), where ‘cold accretion’ emerges and possibly forms SMSs. We perform a suit of cosmological radiation hydrodynamics simulations and investigate star formation after the emergence of cold accretion, solving radiative feedback from stars inside the halo. We follow the mass growth of the protostars for ~3Myr, resolving the gas inflow down to ~0.1 pc scales. We discover that, after cold accretion emerges, multiple SMSs of m[⋆]≳10⁵M[⊙] form at the halo centre with the accretion rates maintained at m[⋆]≃0.04M[⊙]yr⁻¹ for ≲3Myr. Cold accretion supplies gas at a rate of M[gas]≳0.01-0.1M[⊙]yr⁻¹ from outside the halo virial radius to the central gas disc. Gravitational torques from spiral arms transport gas further inwards, which feeds the SMSs. Radiative feedback from stars suppresses H₂ cooling and disc fragmentation, while photoevaporation is prevented by a dense envelope, which attenuates ionizing radiation. Our results suggest that cold accretion can bring efficient BH mass growth after seed formation in the later universe. Moreover, cold accretion and gas migration inside the central disc increase the mass concentration and provide a promising formation site for the extremely compact stellar clusters observed by JWST.</summary> <dc:date>2024-11-01T00:00:00Z</dc:date> </entry> </feed>