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data</title> <meta name="description" content="Search results for: survival data"> <meta name="keywords" content="survival data"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler 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id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="survival data"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 25880</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: survival data</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25700</span> HLA-DPB1 Matching on the Outcome of Unrelated Donor Hematopoietic Stem Cell Transplantation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shi-xia%20Xu">Shi-xia Xu</a>, <a href="https://publications.waset.org/abstracts/search?q=Zai-wen%20Zhang"> Zai-wen Zhang</a>, <a href="https://publications.waset.org/abstracts/search?q=Ru-xue%20Chen"> Ru-xue Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Shan%20Zhou"> Shan Zhou</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiang-feng%20Tang"> Xiang-feng Tang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: The clinical influence of HLA-DPB1 mismatches on clinical outcome of HSCT is less clear. This is the first meta-analysis to study the HLA-DPB1 matching statues on clinical outcomes after unrelated donor HSCT. Methods: We searched the CIBMTR, Cochrane Central Register of Controlled Trials (CENTRAL) and related databases (1995.01–2017.06) for all relevant articles. Comparative studies were used to investigate the HLA-DPB1 loci mismatches on clinical outcomes after unrelated donor HSCT, such as the disease-free survival (DFS), overall survival, GVHD, relapse, and transplant-related mortality (TRM). We performed meta-analysis using Review Manager 5.2 software and funnel plot to assess the bias. Results: At first, 1246 articles were retrieved, and 18 studies totaling 26368 patients analyzed. Pooled comparisons of studies found that the HLA-DPB1 mismatched group had a lower rate of DFS than the DPB1-matched group, and lower OS in non-T cell depleted transplantation. The DPB1 mismatched group has a higher incidence of aGVHD and more severe ( ≥ III degree) aGvHD, lower rate of relapse and higher TRM. Moreover, compared with 1-antigen mismatch, 2-antigen mismatched led to a higher risk of TRM and lower relapse rate. Conclusions: This meta-analysis indicated HLA-DPB1 has important influence on survival and transplant-related complications during unrelated donor HSCT and HLA-DPB1 donor selection strategies have been proposed based on a personalized algorithm. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=human%20leukocyte%20antigen" title="human leukocyte antigen">human leukocyte antigen</a>, <a href="https://publications.waset.org/abstracts/search?q=DPB1" title=" DPB1"> DPB1</a>, <a href="https://publications.waset.org/abstracts/search?q=transplant" title=" transplant"> transplant</a>, <a href="https://publications.waset.org/abstracts/search?q=meta-analysis" title=" meta-analysis"> meta-analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=outcome" title=" outcome"> outcome</a> </p> <a href="https://publications.waset.org/abstracts/86379/hla-dpb1-matching-on-the-outcome-of-unrelated-donor-hematopoietic-stem-cell-transplantation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/86379.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">298</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25699</span> Vitrification-Based Cryopreservation of Phalaenopsis cornu-Cervi (Breda) Blume & Rchb. f. Protocorms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Suphat%20Rittirat">Suphat Rittirat</a>, <a href="https://publications.waset.org/abstracts/search?q=Sutha%20Klaocheed"> Sutha Klaocheed</a>, <a href="https://publications.waset.org/abstracts/search?q=Somporn%20Prasertsongskun"> Somporn Prasertsongskun</a>, <a href="https://publications.waset.org/abstracts/search?q=Kanchit%20Thammasiri"> Kanchit Thammasiri</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Protocorms of Phalaenopsis cornu-cervi (Breda) Blume & Rchb. f. were successfully cryopreserved using a vitrification method. Two-month old protocorms at GI 4 stage were precultured in liquid MS medium supplemented with different concentrations of sucrose (0.3, 0.5, 0.7, 0.9 and 1.2 M) at 25±1°C for 2 days on an orbital shaker at 110 rpm. The protocorms were treated with loading solution (2 M glycerol plus 0.4 M sucrose) for 20 minutes at 25±1°C. Then, the protocorms were sufficiently dehydrated with vitrification solution (plant vitrification solution 2, PVS2) for various times (0, 30, 60, 90 and 120 minutes) at 25±1°C and stored in liquid nitrogen for 1 day. After rapid thawing in water bath at 40°C for 2 minutes, the explants were washed by MS liquid medium containing 0.5 ml of 1.2 M sucrose for 20 minutes. The results shown that the protocorms were precultured in liquid MS medium containing 0.5 M sucrose and dehydrated with vitrification solution for 60 minutes had the highest survival percentage of protocorm at 31±1.0 % as measured by Evan’s blue. No survival rate of protocorms was found without vitrification treatments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=protocorms" title="protocorms">protocorms</a>, <a href="https://publications.waset.org/abstracts/search?q=cryopreservation" title=" cryopreservation"> cryopreservation</a>, <a href="https://publications.waset.org/abstracts/search?q=Phalaenopsis%20cornu-cervi" title=" Phalaenopsis cornu-cervi"> Phalaenopsis cornu-cervi</a>, <a href="https://publications.waset.org/abstracts/search?q=vitrification" title=" vitrification"> vitrification</a> </p> <a href="https://publications.waset.org/abstracts/9351/vitrification-based-cryopreservation-of-phalaenopsis-cornu-cervi-breda-blume-rchb-f-protocorms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/9351.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">363</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25698</span> Formulation and Evaluation of Curcumin-Zn (II) Microparticulate Drug Delivery System for Antimalarial Activity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=M.%20R.%20Aher">M. R. Aher</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20B.%20Laware"> R. B. Laware</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20S.%20%20Asane"> G. S. Asane</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20S.%20Kuchekar"> B. S. Kuchekar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective: Studies have shown that a new combination therapy with Artemisinin derivatives and curcumin is unique, with potential advantages over known ACTs. In present study an attempt was made to prepare microparticulate drug delivery system of Curcumin-Zn complex and evaluate it in combination with artemether for antimalarial activity. Material and method: Curcumin Zn complex was prepared and encapsulated using sodium alginate. Microparticles thus obtained are further coated with various enteric polymers at different coating thickness to control the release. Microparticles are evaluated for encapsulation efficiency, drug loading and in vitro drug release. Roentgenographic Studies was conducted in rabbits with BaSO 4 tagged formulation. Optimized formulation was screened for antimalarial activity using P. berghei-infected mice survival test and % paracetemia inhibition, alone (three oral dose of 5mg/day) and in combination with arthemether (i.p. 500, 1000 and 1500µg). Curcumin-Zn(II) was estimated in serum after oral administration to rats by using spectroflurometry. Result: Microparticles coated with Cellulose acetate phthalate showed most satisfactory and controlled release with 479 min time for 60% drug release. X-ray images taken at different time intervals confirmed the retention of formulation in GI tract. Estimation of curcumin in serum by spectroflurometry showed that drug concentration is maintained in the blood for longer time with tmax of 6 hours. The survival time (40 days post treatment) of mice infected with P. berghei was compared to survival after treatment with either Curcumin-Zn(II) microparticles artemether combination, curcumin-Zn complex and artemether. Oral administration of Curcumin-Zn(II)-artemether prolonged the survival of P.berghei-infected mice. All the mice treated with Curcumin-Zn(II) microparticles (5mg/day) artemether (1000µg) survived for more than 40 days and recovered with no detectable parasitemia. Administration of Curcumin-Zn(II) artemether combination reduced the parasitemia in mice by more than 90% compared to that in control mice for the first 3 days after treatment. Conclusion: Antimalarial activity of the curcumin Zn-artemether combination was more pronounced than mono therapy. A single dose of 1000µg of artemether in curcumin-Zn combination gives complete protection in P. berghei-infected mice. This may reduce the chances of drug resistance in malaria management. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=formulation" title="formulation">formulation</a>, <a href="https://publications.waset.org/abstracts/search?q=microparticulate%20drug%20delivery" title=" microparticulate drug delivery"> microparticulate drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=antimalarial" title=" antimalarial"> antimalarial</a>, <a href="https://publications.waset.org/abstracts/search?q=pharmaceutics" title=" pharmaceutics"> pharmaceutics</a> </p> <a href="https://publications.waset.org/abstracts/26467/formulation-and-evaluation-of-curcumin-zn-ii-microparticulate-drug-delivery-system-for-antimalarial-activity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/26467.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">394</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25697</span> Deep Learning Approach for Colorectal Cancer’s Automatic Tumor Grading on Whole Slide Images</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shenlun%20Chen">Shenlun Chen</a>, <a href="https://publications.waset.org/abstracts/search?q=Leonard%20Wee"> Leonard Wee</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tumor grading is an essential reference for colorectal cancer (CRC) staging and survival prognostication. The widely used World Health Organization (WHO) grading system defines histological grade of CRC adenocarcinoma based on the density of glandular formation on whole slide images (WSI). Tumors are classified as well-, moderately-, poorly- or un-differentiated depending on the percentage of the tumor that is gland forming; >95%, 50-95%, 5-50% and <5%, respectively. However, manually grading WSIs is a time-consuming process and can cause observer error due to subjective judgment and unnoticed regions. Furthermore, pathologists’ grading is usually coarse while a finer and continuous differentiation grade may help to stratifying CRC patients better. In this study, a deep learning based automatic differentiation grading algorithm was developed and evaluated by survival analysis. Firstly, a gland segmentation model was developed for segmenting gland structures. Gland regions of WSIs were delineated and used for differentiation annotating. Tumor regions were annotated by experienced pathologists into high-, medium-, low-differentiation and normal tissue, which correspond to tumor with clear-, unclear-, no-gland structure and non-tumor, respectively. Then a differentiation prediction model was developed on these human annotations. Finally, all enrolled WSIs were processed by gland segmentation model and differentiation prediction model. The differentiation grade can be calculated by deep learning models’ prediction of tumor regions and tumor differentiation status according to WHO’s defines. If multiple WSIs were possessed by a patient, the highest differentiation grade was chosen. Additionally, the differentiation grade was normalized into scale between 0 to 1. The Cancer Genome Atlas, project COAD (TCGA-COAD) project was enrolled into this study. For the gland segmentation model, receiver operating characteristic (ROC) reached 0.981 and accuracy reached 0.932 in validation set. For the differentiation prediction model, ROC reached 0.983, 0.963, 0.963, 0.981 and accuracy reached 0.880, 0.923, 0.668, 0.881 for groups of low-, medium-, high-differentiation and normal tissue in validation set. Four hundred and one patients were selected after removing WSIs without gland regions and patients without follow up data. The concordance index reached to 0.609. Optimized cut off point of 51% was found by “Maxstat” method which was almost the same as WHO system’s cut off point of 50%. Both WHO system’s cut off point and optimized cut off point performed impressively in Kaplan-Meier curves and both p value of logrank test were below 0.005. In this study, gland structure of WSIs and differentiation status of tumor regions were proven to be predictable through deep leaning method. A finer and continuous differentiation grade can also be automatically calculated through above models. The differentiation grade was proven to stratify CAC patients well in survival analysis, whose optimized cut off point was almost the same as WHO tumor grading system. The tool of automatically calculating differentiation grade may show potential in field of therapy decision making and personalized treatment. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title="colorectal cancer">colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=differentiation" title=" differentiation"> differentiation</a>, <a href="https://publications.waset.org/abstracts/search?q=survival%20analysis" title=" survival analysis"> survival analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=tumor%20grading" title=" tumor grading"> tumor grading</a> </p> <a href="https://publications.waset.org/abstracts/136085/deep-learning-approach-for-colorectal-cancers-automatic-tumor-grading-on-whole-slide-images" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/136085.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">134</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25696</span> Evaluation of the Efficacy of Basic Life Support Teaching in Second and Third Year Medical Students</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Bianca%20W.%20O.%20Silva">Bianca W. O. Silva</a>, <a href="https://publications.waset.org/abstracts/search?q=Adriana%20C.%20M.%20Andrade"> Adriana C. M. Andrade</a>, <a href="https://publications.waset.org/abstracts/search?q=Gustavo%20C.%20M.%20Lucena"> Gustavo C. M. Lucena</a>, <a href="https://publications.waset.org/abstracts/search?q=Virna%20M.%20S.%20Lima"> Virna M. S. Lima </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Basic life support (BLS) involves the immediate recognition of cardiopulmonary arrest. Each year, 359.400 and 275.000 individuals with cardiac arrest are attended in emergency departments in USA and Europe. Brazilian data shows that 200.000 cardiac arrests occur every year, and half of them out of the hospital. Medical schools around the world teach BLS in the first years of the course, but studies show that there is a decline of the knowledge as the years go by, affecting the chain of survival. The objective was to analyze the knowledge of medical students about BLS and the retention of this learning throughout the course. Methods: This study included 150 students who were at the second and third year of a medical school in Salvador, Bahia, Brazil. The instrument of data collection was a structured questionnaire composed of 20 questions based on the 2015 American Heart Association guideline. The Pearson Chi-square test was used in order to study the association between previous training, sex and semester with the degree of knowledge of the students. The Kruskal-Wallis test was used to evaluate the different yields obtained between the various semesters. The number of correct answers was described by average and quartiles. Results: Regarding the degree of knowledge, 19.6% of the female students reached the optimal classification, a better outcome than the achieved by the male participants. Of those with previous training, 33.33% were classified as good and optimal, none of the students reached the optimal classification and only 2.2% of them were classified as bad (those who did not have 52.6% of correct answers). The analysis of the degree of knowledge related to each semester revealed that the 5th semester had the highest outcome: 30.5%. However, the acquaintance presented by the semesters was generally unsatisfactory, since 50% of the students, or more, demonstrated knowledge levels classified as bad or regular. When confronting the different semesters and the achieved scores, the value of p was 0.831. Conclusion: It is important to focus on the training of medical professionals that are capable of facing emergency situations, improving the systematization of care, and thereby increasing the victims' possibility of survival. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=basic%20life%20support" title="basic life support">basic life support</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiopulmonary%20ressucitacion" title=" cardiopulmonary ressucitacion"> cardiopulmonary ressucitacion</a>, <a href="https://publications.waset.org/abstracts/search?q=education" title=" education"> education</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20students" title=" medical students "> medical students </a> </p> <a href="https://publications.waset.org/abstracts/76831/evaluation-of-the-efficacy-of-basic-life-support-teaching-in-second-and-third-year-medical-students" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/76831.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">186</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25695</span> The Consequences of COVID-19 Crisis on Informal Workers in Brazil: An Analysis of Emergency Aid from the Government </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Michele%20Romanello">Michele Romanello</a> </p> <p class="card-text"><strong>Abstract:</strong></p> COVID-19 has spread rapidly in Brazil since March 2020, making the country one of the most affected in the world by the pandemic. From an economic point of view, Brazil came from a pre-pandemic period characterized by low or negative growth, with a resulting increase in the number of unemployed and informal workers. This paper considers lockdown implementation in the situation of the large presence of informality in the economy. The objective of the paper is to analyze how the country has tried to help workers affected by economic crisis after the implementation of measures against COVID-19 and whether the emergency assistance from the government has been adequate to contain the increase of informal workers and unemployed. The methodology used in this paper is survival analysis. Through this methodology, the formality – informality, and informality – unemployment transitions are analyzed. This analysis draws data from the Continuous National Household Sample Survey (Continuous PNAD) and from the National Household Sample Survey COVID-19 (PNAD COVID-19) covering the period of January 2020 – July 2020. The results indicate that emergency aid has been not sufficient to reduce the transitions of workers from formal to informal jobs and from informal jobs to unemployment. Emergency aid has been not sufficient considering the previous situation of the country, with levels of poverty and inequality very high. In the next months, another fundamental determinant of the income trajectory in the context of the COVID-19 crisis will be the continuity of the emergency aid, especially considering the fiscal adjustment policy pursued by the government. Therefore, the current negative portrait may be even worse in the coming months. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Brazil" title="Brazil">Brazil</a>, <a href="https://publications.waset.org/abstracts/search?q=COVID-19" title=" COVID-19"> COVID-19</a>, <a href="https://publications.waset.org/abstracts/search?q=informality" title=" informality"> informality</a>, <a href="https://publications.waset.org/abstracts/search?q=survival%20analysis" title=" survival analysis"> survival analysis</a> </p> <a href="https://publications.waset.org/abstracts/130156/the-consequences-of-covid-19-crisis-on-informal-workers-in-brazil-an-analysis-of-emergency-aid-from-the-government" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/130156.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">112</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25694</span> Thermalytix: An Advanced Artificial Intelligence Based Solution for Non-Contact Breast Screening</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Sudhakar">S. Sudhakar</a>, <a href="https://publications.waset.org/abstracts/search?q=Geetha%20Manjunath"> Geetha Manjunath</a>, <a href="https://publications.waset.org/abstracts/search?q=Siva%20Teja%20Kakileti"> Siva Teja Kakileti</a>, <a href="https://publications.waset.org/abstracts/search?q=Himanshu%20Madhu"> Himanshu Madhu </a> </p> <p class="card-text"><strong>Abstract:</strong></p> Diagnosis of breast cancer at early stages has seen better clinical and survival outcomes. Survival rates in developing countries like India are very low due to accessibility and affordability issues of screening tests such as Mammography. In addition, Mammography is not much effective in younger women with dense breasts. This leaves a gap in current screening methods. Thermalytix is a new technique for detecting breast abnormality in a non-contact, non-invasive way. It is an AI-enabled computer-aided diagnosis solution that automates interpretation of high resolution thermal images and identifies potential malignant lesions. The solution is low cost, easy to use, portable and is effective in all age groups. This paper presents the results of a retrospective comparative analysis of Thermalytix over Mammography and Clinical Breast Examination for breast cancer screening. Thermalytix was found to have better sensitivity than both the tests, with good specificity as well. In addition, Thermalytix identified all malignant patients without palpable lumps. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer%20screening" title="breast cancer screening">breast cancer screening</a>, <a href="https://publications.waset.org/abstracts/search?q=radiology" title=" radiology"> radiology</a>, <a href="https://publications.waset.org/abstracts/search?q=thermalytix" title=" thermalytix"> thermalytix</a>, <a href="https://publications.waset.org/abstracts/search?q=artificial%20intelligence" title=" artificial intelligence"> artificial intelligence</a>, <a href="https://publications.waset.org/abstracts/search?q=thermography" title=" thermography"> thermography</a> </p> <a href="https://publications.waset.org/abstracts/87848/thermalytix-an-advanced-artificial-intelligence-based-solution-for-non-contact-breast-screening" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/87848.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">291</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25693</span> Influence of Farnesol on Growth and Development of Dysdercus koenigii</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shailendra%20Kumar">Shailendra Kumar</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamal%20Kumar%20Gupta"> Kamal Kumar Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Dysdercus koenigii is an economically important pest of cotton worldwide. The pest damages the crop by sucking sap, staining lint, reducing the oil content of the seeds and deteriorating the quality of cotton. Plant possesses a plethora of secondary metabolites which are used as defense mechanism against herbivores. One of the important categories of such chemicals is insect growth regulators and the intermediates in their biosynthesis. Farnesol belongs to sesquiterpenoid. It is an intermediate in Juvenile hormone biosynthetic pathway in insects has been widely reported in the variety of plants. This chemical can disrupt the normal metabolic function and therefore, affects various life processes of the insects. Present study tested the efficacy of farnesol against Dysdercus koenigii. 2μl of 5% (100µg) and 10% (200µg) of the farnesol was applied topically on the dorsum of thoracic region of the newly emerged fifth instar nymphs of Dysdercus. The treated insects were observed daily for their survival, weight gain, and developmental anomalies for a period of ten days. The results indicated that treatment with 200µg farnesol decreased survival of the insects to 70% after 24h of exposure. At lower doses, no significant decrease in the survival was observed. However, the surviving nymphs showed alteration in growth, development, and metamorphosis. The weight gain in the treated nymphs showed deviation from control. The treated nymphs showed an increase in mortality during subsequent days and increase in the nymphal duration. The number of nymphs undergoing metamorphosis decreased to 46% and 88% in the treatments with the dose of 200µg and 100µg respectively. Severe developmental anomalies were also observed in the treated nymphs. The treated nymphs moulted into supernumerary nymphs, adultoids, adults with exuviae attached and adults with wing deformities. On treatment with 200µg; 26% adultoid, 4% adults with exuviae attached and 12% adults with wing deformed were produced. Treatment with 100µg resulted in production of 34% adultoid, 26% adults with deformed wing and 4% adults with exuviae attached. Many of the treated nymphs did not metamorphose into adults, remained in nymphal stage and died. Our results indicated potential application plant-derived secondary metabolites like farnesol in the management of Dysdercus population. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=development" title="development">development</a>, <a href="https://publications.waset.org/abstracts/search?q=Dysdercus%20koenigii" title=" Dysdercus koenigii"> Dysdercus koenigii</a>, <a href="https://publications.waset.org/abstracts/search?q=farnesol" title=" farnesol"> farnesol</a>, <a href="https://publications.waset.org/abstracts/search?q=survival" title=" survival"> survival</a> </p> <a href="https://publications.waset.org/abstracts/69126/influence-of-farnesol-on-growth-and-development-of-dysdercus-koenigii" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/69126.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">355</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25692</span> On Consolidated Predictive Model of the Natural History of Breast Cancer Considering Primary Tumor and Primary Distant Metastases Growth</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ella%20Tyuryumina">Ella Tyuryumina</a>, <a href="https://publications.waset.org/abstracts/search?q=Alexey%20Neznanov"> Alexey Neznanov</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Finding algorithms to predict the growth of tumors has piqued the interest of researchers ever since the early days of cancer research. A number of studies were carried out as an attempt to obtain reliable data on the natural history of breast cancer growth. Mathematical modeling can play a very important role in the prognosis of tumor process of breast cancer. However, mathematical models describe primary tumor growth and metastases growth separately. Consequently, we propose a mathematical growth model for primary tumor and primary metastases which may help to improve predicting accuracy of breast cancer progression using an original mathematical model referred to CoM-IV and corresponding software. We are interested in: 1) modelling the whole natural history of primary tumor and primary metastases; 2) developing adequate and precise CoM-IV which reflects relations between PT and MTS; 3) analyzing the CoM-IV scope of application; 4) implementing the model as a software tool. The CoM-IV is based on exponential tumor growth model and consists of a system of determinate nonlinear and linear equations; corresponds to TNM classification. It allows to calculate different growth periods of primary tumor and primary metastases: 1) ‘non-visible period’ for primary tumor; 2) ‘non-visible period’ for primary metastases; 3) ‘visible period’ for primary metastases. The new predictive tool: 1) is a solid foundation to develop future studies of breast cancer models; 2) does not require any expensive diagnostic tests; 3) is the first predictor which makes forecast using only current patient data, the others are based on the additional statistical data. Thus, the CoM-IV model and predictive software: a) detect different growth periods of primary tumor and primary metastases; b) make forecast of the period of primary metastases appearance; c) have higher average prediction accuracy than the other tools; d) can improve forecasts on survival of BC and facilitate optimization of diagnostic tests. The following are calculated by CoM-IV: the number of doublings for ‘nonvisible’ and ‘visible’ growth period of primary metastases; tumor volume doubling time (days) for ‘nonvisible’ and ‘visible’ growth period of primary metastases. The CoM-IV enables, for the first time, to predict the whole natural history of primary tumor and primary metastases growth on each stage (pT1, pT2, pT3, pT4) relying only on primary tumor sizes. Summarizing: a) CoM-IV describes correctly primary tumor and primary distant metastases growth of IV (T1-4N0-3M1) stage with (N1-3) or without regional metastases in lymph nodes (N0); b) facilitates the understanding of the appearance period and manifestation of primary metastases. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=exponential%20growth%20model" title=" exponential growth model"> exponential growth model</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20modelling" title=" mathematical modelling"> mathematical modelling</a>, <a href="https://publications.waset.org/abstracts/search?q=primary%20metastases" title=" primary metastases"> primary metastases</a>, <a href="https://publications.waset.org/abstracts/search?q=primary%20tumor" title=" primary tumor"> primary tumor</a>, <a href="https://publications.waset.org/abstracts/search?q=survival" title=" survival"> survival</a> </p> <a href="https://publications.waset.org/abstracts/65180/on-consolidated-predictive-model-of-the-natural-history-of-breast-cancer-considering-primary-tumor-and-primary-distant-metastases-growth" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/65180.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">334</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25691</span> Influence of Catharanthus roseus, Ocimum sanctum and Lantana camara Extracts on Survival and Longevity of Dysdercus koenigii</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kayesth">Sunil Kayesth</a>, <a href="https://publications.waset.org/abstracts/search?q=Kamal%20Kumar%20Gupta"> Kamal Kumar Gupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The development of resistance among insects and pests, environmental contamination and adverse effects on non-target organisms is contributed by the indiscriminate use of chemical based insecticides. To overcome these environmental and other ecological issues that are need to replace these harmful toxic compounds. The present study was designed to evaluate the effect of Catharanthus roseus, Ocimum sanctum and Lantana camara plants volatiles on survival and longevity of Dysdercus koenigii. The hexane extract and ethanol extracts of these three plants were used. The fifth instars were exposed to hexane extract with concentrations of 10%, 5%, 2.5% 1.25%, 0.1%, 0.5% 0.25%, 0.125% and 0.0625% while, adults were treated with10%, 5%, 2.5% and 1.25%. 1-ml of each of these concentrations was used to make a thin film in sterilized glass jars of 500 ml capacity. Fifteen- newly emerged fifth instar nymphs and adult bugs were treated separately with the extracts for 24- hour exposure to the plant volatiles. For ethanol extracts cottonseed were treated with ethanol extracts of 10%, 5%, 2.5% and 1.25% concentrations. The treated seeds were provided to the Dysdercus for a period of 24 hours and their feeding behaviour was observed. The effect of hexane and ethanol extract of these plants was observed and readings were recorded for 15 days. Survival and longevity of both fifth instars and adults were in correlation with the concentrations of the plant extracts. Among three plant extracts, Ocimum hexane extract was most toxic and Catharanthus was moderate while Lantana was least toxic. The ethanol extracts of Lantana was highly antifeedent while Ocimum was moderate and Catharanthus was least antifeedent. Both Catharanthus and Ocimum appeared to have potential molecules, which possessed insecticidal activity while Ocimum and Lantana showed antifeedent activities. These insecticidal and antifeedent properties may be used in IPM. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Catharanthus%20roseus" title="Catharanthus roseus">Catharanthus roseus</a>, <a href="https://publications.waset.org/abstracts/search?q=Ocimum%20sanctum" title=" Ocimum sanctum"> Ocimum sanctum</a>, <a href="https://publications.waset.org/abstracts/search?q=Lantana%20camara" title=" Lantana camara"> Lantana camara</a>, <a href="https://publications.waset.org/abstracts/search?q=Dysdercus%20koenigii" title=" Dysdercus koenigii "> Dysdercus koenigii </a> </p> <a href="https://publications.waset.org/abstracts/39732/influence-of-catharanthus-roseus-ocimum-sanctum-and-lantana-camara-extracts-on-survival-and-longevity-of-dysdercus-koenigii" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/39732.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">318</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25690</span> The Design of a Phase I/II Trial of Neoadjuvant RT with Interdigitated Multiple Fractions of Lattice RT for Large High-grade Soft-Tissue Sarcoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Georges%20F.%20Hatoum">Georges F. Hatoum</a>, <a href="https://publications.waset.org/abstracts/search?q=Thomas%20H.%20Temple"> Thomas H. Temple</a>, <a href="https://publications.waset.org/abstracts/search?q=Silvio%20Garcia"> Silvio Garcia</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiaodong%20Wu"> Xiaodong Wu</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Soft Tissue Sarcomas (STS) represent a diverse group of malignancies with heterogeneous clinical and pathological features. The treatment of extremity STS aims to achieve optimal local tumor control, improved survival, and preservation of limb function. The National Comprehensive Cancer Network guidelines, based on the cumulated clinical data, recommend radiation therapy (RT) in conjunction with limb-sparing surgery for large, high-grade STS measuring greater than 5 cm in size. Such treatment strategy can offer a cure for patients. However, when recurrence occurs (in nearly half of patients), the prognosis is poor, with a median survival of 12 to 15 months and with only palliative treatment options available. The spatially-fractionated-radiotherapy (SFRT), with a long history of treating bulky tumors as a non-mainstream technique, has gained new attention in recent years due to its unconventional therapeutic effects, such as bystander/abscopal effects. Combining single fraction of GRID, the original form of SFRT, with conventional RT was shown to have marginally increased the rate of pathological necrosis, which has been recognized to have a positive correlation to overall survival. In an effort to consistently increase the pathological necrosis rate over 90%, multiple fractions of Lattice RT (LRT), a newer form of 3D SFRT, interdigitated with the standard RT as neoadjuvant therapy was conducted in a preliminary clinical setting. With favorable results of over 95% of necrosis rate in a small cohort of patients, a Phase I/II clinical study was proposed to exam the safety and feasibility of this new strategy. Herein the design of the clinical study is presented. In this single-arm, two-stage phase I/II clinical trial, the primary objectives are >80% of the patients achieving >90% tumor necrosis and to evaluation the toxicity; the secondary objectives are to evaluate the local control, disease free survival and overall survival (OS), as well as the correlation between clinical response and the relevant biomarkers. The study plans to accrue patients over a span of two years. All patient will be treated with the new neoadjuvant RT regimen, in which one of every five fractions of conventional RT is replaced by a LRT fraction with vertices receiving dose ≥10Gy while keeping the tumor periphery at or close to 2 Gy per fraction. Surgical removal of the tumor is planned to occur 6 to 8 weeks following the completion of radiation therapy. The study will employ a Pocock-style early stopping boundary to ensure patient safety. The patients will be followed and monitored for a period of five years. Despite much effort, the rarity of the disease has resulted in limited novel therapeutic breakthroughs. Although a higher rate of treatment-induced tumor necrosis has been associated with improved OS, with the current techniques, only 20% of patients with large, high-grade tumors achieve a tumor necrosis rate exceeding 50%. If this new neoadjuvant strategy is proven effective, an appreciable improvement in clinical outcome without added toxicity can be anticipated. Due to the rarity of the disease, it is hoped that such study could be orchestrated in a multi-institutional setting. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lattice%20RT" title="lattice RT">lattice RT</a>, <a href="https://publications.waset.org/abstracts/search?q=necrosis" title=" necrosis"> necrosis</a>, <a href="https://publications.waset.org/abstracts/search?q=SFRT" title=" SFRT"> SFRT</a>, <a href="https://publications.waset.org/abstracts/search?q=soft%20tissue%20sarcoma" title=" soft tissue sarcoma"> soft tissue sarcoma</a> </p> <a href="https://publications.waset.org/abstracts/169684/the-design-of-a-phase-iii-trial-of-neoadjuvant-rt-with-interdigitated-multiple-fractions-of-lattice-rt-for-large-high-grade-soft-tissue-sarcoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/169684.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">60</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25689</span> Palliative Performance Scale Differences between Patients Referred by Specialized Cancer Center and General Hospitals to the Palliative Care Center in Kuwait</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Khalid%20Al%20Saleh">Khalid Al Saleh</a>, <a href="https://publications.waset.org/abstracts/search?q=Najlaa%20AlSayed"> Najlaa AlSayed</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Palliative care is changing from just ‘end of life care’ to care delivered earlier in the disease course. Metanalysis showed that Palliative Performance Scale (PPS) is associated with increased length of survival. The Palliative Care Center (PCC) in Kuwait is the only stand-alone center in Eastern Mediterranean Region with a capacity of 92 beds. We compared clinical characteristics between patients referred from the Specialized Cancer Center and general hospitals in Kuwait to PCC. Method: A cross Sectional survey was conducted since the opening of PCC in January 2011 to June 2013. Patients’ data on demographics, type of the cancer, PPS score and referring hospital were collected and analyzed. Results: Total number of the patients was 142. Mean age was 61.05±14.79 years, 66 patients (47.1%) were males and 74 (52.9%) were females. The most common cancers in males were lung (n=18, 27.3%) followed by head and neck cancers (n=8, 12.1%) and brain tumors (n=7, 10.6%) while in females, the most common cancers were breast cancer (n=12, 16.7%) followed by ovarian cancer (n=10, 13.9%) and Cancer Colon (n=8, 11.1%). Patients with PPS score 30% were 27.9% (n=39), 40% in 40.7% (n=57), and 50% in 17.1% (n=24) respectively. Patients referred from the Specialized Cancer Center had significantly higher portion of patients with PPS score > 30% (73.4%, n=94), compared to patients coming from general hospitals (33.3%, n=4), P value= 0.007. Conclusion: There is significant difference in PPS scores between patients referred from the Specialized Cancer Center compared to patients referred from general hospitals. We encourage that all cancer patients should be treated in Specialized Cancer Centers and earlier involvement of Palliative Care Centers to achieve better survival. Training workshops are needed for health care professionals working in general hospitals to raise awareness about earlier referral of patients to palliative care services. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=palliative%20care" title="palliative care">palliative care</a>, <a href="https://publications.waset.org/abstracts/search?q=kuwait" title=" kuwait"> kuwait</a>, <a href="https://publications.waset.org/abstracts/search?q=performance%20scale%20differences" title=" performance scale differences"> performance scale differences</a>, <a href="https://publications.waset.org/abstracts/search?q=pps%20score" title=" pps score"> pps score</a>, <a href="https://publications.waset.org/abstracts/search?q=specialized%20hospitals" title=" specialized hospitals"> specialized hospitals</a> </p> <a href="https://publications.waset.org/abstracts/40327/palliative-performance-scale-differences-between-patients-referred-by-specialized-cancer-center-and-general-hospitals-to-the-palliative-care-center-in-kuwait" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/40327.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">305</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25688</span> The Predictive Value of Serum Bilirubin in the Post-Transplant De Novo Malignancy: A Data Mining Approach</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nasim%20Nosoudi">Nasim Nosoudi</a>, <a href="https://publications.waset.org/abstracts/search?q=Amir%20Zadeh"> Amir Zadeh</a>, <a href="https://publications.waset.org/abstracts/search?q=Hunter%20White"> Hunter White</a>, <a href="https://publications.waset.org/abstracts/search?q=Joshua%20Conrad"> Joshua Conrad</a>, <a href="https://publications.waset.org/abstracts/search?q=Joon%20W.%20Shim"> Joon W. Shim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> De novo Malignancy has become one of the major causes of death after transplantation, so early cancer diagnosis and detection can drastically improve survival rates post-transplantation. Most previous work focuses on using artificial intelligence (AI) to predict transplant success or failure outcomes. In this work, we focused on predicting de novo malignancy after liver transplantation using AI. We chose the patients that had malignancy after liver transplantation with no history of malignancy pre-transplant. Their donors were cancer-free as well. We analyzed 254,200 patient profiles with post-transplant malignancy from the US Organ Procurement and Transplantation Network (OPTN). Several popular data mining methods were applied to the resultant dataset to build predictive models to characterize de novo malignancy after liver transplantation. Recipient's bilirubin, creatinine, weight, gender, number of days recipient was on the transplant waiting list, Epstein Barr Virus (EBV), International normalized ratio (INR), and ascites are among the most important factors affecting de novo malignancy after liver transplantation <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=De%20novo%20malignancy" title="De novo malignancy">De novo malignancy</a>, <a href="https://publications.waset.org/abstracts/search?q=bilirubin" title=" bilirubin"> bilirubin</a>, <a href="https://publications.waset.org/abstracts/search?q=data%20mining" title=" data mining"> data mining</a>, <a href="https://publications.waset.org/abstracts/search?q=transplantation" title=" transplantation"> transplantation</a> </p> <a href="https://publications.waset.org/abstracts/149495/the-predictive-value-of-serum-bilirubin-in-the-post-transplant-de-novo-malignancy-a-data-mining-approach" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/149495.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">105</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25687</span> Evaluation of Entomopathogenic Fungi Strains for Field Persistence and Its Relationship to in Vitro Heat Tolerance</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mulue%20Girmay%20Gebreslasie">Mulue Girmay Gebreslasie</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Entomopathogenic fungi are naturally safe and eco-friendly biological agents. Their potential of host specificity and ease handling made them appealing options to substitute synthetic pesticides in pest control programs. However, they are highly delicate and unstable under field conditions. Therefore, the current experiment was held to search out persistent fungal strains by defining the relationship between invitro heat tolerance and field persistence. Current results on leaf and soil persistence assay revealed that strains of Metarhizium species, M. pingshaense (F2685), M. pingshaense (MS2) and M. brunneum (F709) exhibit maximum cumulative CFUs count, relative survival rate and least percent of CFUs reductions showed significant difference at 7 days and 28 days post inoculations (dpi) in hot seasons from sampled soils and leaves and in cold season from soil samples. Whereas relative survival of B. brongniartii (TNO6) found significantly higher in cold weather leaf treatment application as compared to hot season and found as persistent as other fungal strains, while higher deterioration of fungal conidia seen with M. pingshaense (MS2). In the current study, strains of Beauveria brongniartii (TNO6) and Cordyceps javanica (Czy-LP) were relatively vulnerable in field condition with utmost colony forming units (CFUs) reduction and least survival rates. Further, the relationship of the two parameters (heat tolerance and field persistence) was seen with strong linear positive correlations elucidated that heat test could be used in selection of field persistent fungal strains for hot season applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=integrated%20pest%20management" title="integrated pest management">integrated pest management</a>, <a href="https://publications.waset.org/abstracts/search?q=biopesticides" title=" biopesticides"> biopesticides</a>, <a href="https://publications.waset.org/abstracts/search?q=Insect%20pathology%20and%20microbial%20control" title=" Insect pathology and microbial control"> Insect pathology and microbial control</a>, <a href="https://publications.waset.org/abstracts/search?q=entomology" title=" entomology"> entomology</a> </p> <a href="https://publications.waset.org/abstracts/167965/evaluation-of-entomopathogenic-fungi-strains-for-field-persistence-and-its-relationship-to-in-vitro-heat-tolerance" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/167965.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">99</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25686</span> Biologically Synthesised Silver Nanoparticles Induces Autophagy and JNK Signaling as a Pro-Survival Response by Abrogating Reactive Oxygen Species Accumulation in Cancer Cells</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sudeshna%20Mukherjee">Sudeshna Mukherjee</a>, <a href="https://publications.waset.org/abstracts/search?q=Leena%20Fageria"> Leena Fageria</a>, <a href="https://publications.waset.org/abstracts/search?q=R.%20Venkataramana%20Dilip"> R. Venkataramana Dilip</a>, <a href="https://publications.waset.org/abstracts/search?q=Rajdeep%20Chowdhury"> Rajdeep Chowdhury</a>, <a href="https://publications.waset.org/abstracts/search?q=Jitendra%20Panwar"> Jitendra Panwar</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Metal nanoparticles in recent years have gained importance in cancer therapy due to their enhanced permeability retention effect. Among various nanomaterials, silver nanoparticles (AgNPs) have received considerable attention due to their unique properties like conductivity, chemical stability, relative lower toxicity and outstanding therapeutic potential, such as anti-inflammatory, antimicrobial and anti-cancerous activities. In this study, we took a greener approach to synthesize silver nanoparticle from fungus and analyze its effects on both epithelial and mesenchymal derived cancer cells. Much research has been done on nanoparticle-induced apoptosis, but little is known about its role in autophagy. In our study, the silver nanoparticles were seen to induce autophagy which was analyzed by studying the expression of several autophagy markers like, LC3B-II and ATG genes. Monodansylcadaverine (MDC) assay also revealed the induction of autophagy upon treatment with AgNPs. Inhibition of autophagy by chloroquine resulted in increased cell death suggesting autophagy as a survival strategy adopted by the cells. In parallel to autophagy induction, silver nanoparticles induced ROS accumulation. Interestingly, autophagy inhibition by chloroquine increased ROS level, resulting in enhanced cell death. We further analyzed MAPK signaling upon AgNP treatment. It was observed that along with autophagy, activation of JNK signaling served as pro-survival while ERK signaling served as a pro-death signal. Our results provide valuable insights into the role of autophagy upon AgNP exposure and provide cues to probabilistic strategies to effectively sensitize cancer cells. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=autophagy" title="autophagy">autophagy</a>, <a href="https://publications.waset.org/abstracts/search?q=JNK%20signalling" title=" JNK signalling"> JNK signalling</a>, <a href="https://publications.waset.org/abstracts/search?q=reactive%20oxygen%20species" title=" reactive oxygen species"> reactive oxygen species</a>, <a href="https://publications.waset.org/abstracts/search?q=silver%20nanoparticles" title=" silver nanoparticles"> silver nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/63782/biologically-synthesised-silver-nanoparticles-induces-autophagy-and-jnk-signaling-as-a-pro-survival-response-by-abrogating-reactive-oxygen-species-accumulation-in-cancer-cells" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/63782.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">364</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25685</span> Identifying the Host Substrates for the Mycobacterial Virulence Factor Protein Kinase G</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Saha%20Saradindu">Saha Saradindu</a>, <a href="https://publications.waset.org/abstracts/search?q=Das%20Payel"> Das Payel</a>, <a href="https://publications.waset.org/abstracts/search?q=Somdeb%20BoseDasgupta"> Somdeb BoseDasgupta</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Tuberculosis caused by Mycobacteria tuberculosis is a dreadful disease and more so with the advent of extreme and total drug-resistant species. Mycobacterial pathogenesis is an ever-changing paradigm from phagosome maturation block to phagosomal escape into macrophage cytosol and finally acid tolerance and survival inside the lysosome. Mycobacteria are adept at subverting the host immune response by highjacking host cell signaling and secreting virulence factors. One such virulence factor is a ser/thr kinase; Protein kinase G (PknG), which is known to prevent phagosome maturation. The host substrates of PknG, allowing successful pathogenesis still remain an enigma. Hence we carried out a comparative phosphoproteomic screen and identified a number of substrates phosphorylated by PknG. We characterized some of these substrates in vivo and in vitro and observed that PknG mediated phosphorylation of these substrates leads to reduced TNFa production as well as decreased response to TNFa induced macrophage necroptosis, thus enabling mycobacterial survival and proliferation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=mycobacteria" title="mycobacteria">mycobacteria</a>, <a href="https://publications.waset.org/abstracts/search?q=Protein%20kinase%20G" title=" Protein kinase G"> Protein kinase G</a>, <a href="https://publications.waset.org/abstracts/search?q=phosphoproteomics" title=" phosphoproteomics"> phosphoproteomics</a>, <a href="https://publications.waset.org/abstracts/search?q=necroptosis" title=" necroptosis"> necroptosis</a> </p> <a href="https://publications.waset.org/abstracts/100666/identifying-the-host-substrates-for-the-mycobacterial-virulence-factor-protein-kinase-g" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/100666.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">146</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25684</span> The Predictive Significance of Metastasis Associated in Colon Cancer-1 (MACC1) in Primary Breast Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jasminka%20Mujic">Jasminka Mujic</a>, <a href="https://publications.waset.org/abstracts/search?q=Karin%20Milde-Langosch"> Karin Milde-Langosch</a>, <a href="https://publications.waset.org/abstracts/search?q=Volkmar%20Mueller"> Volkmar Mueller</a>, <a href="https://publications.waset.org/abstracts/search?q=Mirza%20Suljagic"> Mirza Suljagic</a>, <a href="https://publications.waset.org/abstracts/search?q=Tea%20Becirevic"> Tea Becirevic</a>, <a href="https://publications.waset.org/abstracts/search?q=Jozo%20Coric"> Jozo Coric</a>, <a href="https://publications.waset.org/abstracts/search?q=Daria%20Ler"> Daria Ler</a> </p> <p class="card-text"><strong>Abstract:</strong></p> MACC1 (metastasis associated in colon cancer-1) is a prognostic biomarker for tumor progression, metastasis, and survival of a variety of solid cancers. MACC1 also causes tumor growth in xenograft models and acts as a master regulator of the HGF/MET signaling pathway. In breast cancer, the expression of MACC1 determined by immunohistochemistry was significantly associated with positive lymph node status and advanced clinical stage. The aim of the present study was to further investigate the prognostic or predictive value of MACC1 expression in breast cancer using western blot analysis and immunohistochemistry. The results of our study have shown that high MACC1 expression in breast cancer is associated with shorter disease-free survival, especially in node-negative tumors. The MACC1 might be a suitable biomarker to select patients with a higher probability of recurrence which might benefit from adjuvant chemotherapy. Our results support a biologic role and potentially open the perspective for the use of MACC1 as predictive biomarker for treatment decision in breast cancer patients. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=breast%20cancer" title="breast cancer">breast cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=biomarker" title=" biomarker"> biomarker</a>, <a href="https://publications.waset.org/abstracts/search?q=HGF%2FMET" title=" HGF/MET"> HGF/MET</a>, <a href="https://publications.waset.org/abstracts/search?q=MACC1" title=" MACC1"> MACC1</a> </p> <a href="https://publications.waset.org/abstracts/86514/the-predictive-significance-of-metastasis-associated-in-colon-cancer-1-macc1-in-primary-breast-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/86514.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">233</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25683</span> High Temperature Tolerance of Chironomus Sulfurosus and Its Molecular Mechanisms</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Tettey%20Afi%20Pamela">Tettey Afi Pamela</a>, <a href="https://publications.waset.org/abstracts/search?q=Sotaro%20Fujii"> Sotaro Fujii</a>, <a href="https://publications.waset.org/abstracts/search?q=Hidetoshi%20Saito"> Hidetoshi Saito</a>, <a href="https://publications.waset.org/abstracts/search?q=Kawaii%20Koichiro"> Kawaii Koichiro</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Introduction: Organisms employ adaptive mechanisms when faced with any stressor or risk of being wiped out. This has made it possible for them to survive in harsh environmental conditions such as increasing temperature, low pH, and anoxia. Some of the mechanisms they utilize include the expression of heat shock proteins, synthesis of cryoprotectants, and anhydrobiosis. Heat shock proteins (HSPs) have been widely studied to determine their involvement in stress tolerance among various organism, of which chironomid species have been no exception. We examined the survival and expression of genes encoding five (5) heat shock proteins (HSP70, HSP67, HSP60, HSP27, and HSP23) from Chironomus sulfurosus larvae reared from 1st instar at 25°C, 30°C, 35°C, and 40°C. Results: The highest survival rate was recorded at 30°C, followed by 25°C, then 35°C. Only a small percentage of C. sulfurosus survived at 40°C (14.5%). With regards to HSPs expression, some HSPs responded to an increase in high temperature. The relative expression levels were lowest at 30°C for HSP70, HSP60, HSP27, and HSP23. At 25°C and 40°C, HSP70, HSP67, HSP60, HSP27, and HSP23 had the highest expression. At 35°C, all had the lowest expression. Discussion: The expression of heat shock proteins varies from one species to another. We designated the genes HSP 70, HSP 67, HSP 60, HSP 27, and HSP 23 genes based on transcriptome analysis of C. sulfurosus. Our study can be termed as a long-heat shock study as C. sulfurosus was reared from the first instar to the fourth instar, and this might have led to a continuous induction of HSPs at 25°C. 40°C had the lowest survival but highest HSPs expression as C. sulfurosus larvae had to utilize HSPs for sustenance. These results and future high-throughput studies at both the transcriptome and proteome level will improve the information needed to predict the future geographic distribution of these species within the context of global warming. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=chironomid" title="chironomid">chironomid</a>, <a href="https://publications.waset.org/abstracts/search?q=heat%20shock%20proteins" title=" heat shock proteins"> heat shock proteins</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20temperature" title=" high temperature"> high temperature</a>, <a href="https://publications.waset.org/abstracts/search?q=heat%20shock%20protein%20expression" title=" heat shock protein expression"> heat shock protein expression</a> </p> <a href="https://publications.waset.org/abstracts/152441/high-temperature-tolerance-of-chironomus-sulfurosus-and-its-molecular-mechanisms" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152441.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">95</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25682</span> Micropropagation and in vitro Conservation via Slow Growth Techniques of Prunus webbii (Spach) Vierh: An Endangered Plant Species in Albania</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Valbona%20Sota">Valbona Sota</a>, <a href="https://publications.waset.org/abstracts/search?q=Efigjeni%20Kongjika"> Efigjeni Kongjika</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Wild almond is a woody species, which is difficult to propagate either generatively by seed or by vegetative methods (grafting or cuttings) and also considered as Endangered (EN) in Albania based on IUCN criteria. As a wild relative of cultivated fruit trees, this species represents a source of genetic variability and can be very important in breeding programs and cultivation. For this reason, it would be of interest to use an effective method of in vitro mid-term conservation, which involves strategies to slow plant growth through physicochemical alterations of in vitro growth conditions. Multiplication of wild almond was carried out using zygotic embryos, as primary explants, with the purpose to develop a successful propagation protocol. Results showed that zygotic embryos can proliferate through direct or indirect organogenesis. During subculture, stage was obtained a great number of new plantlets identical to mother plants derived from the zygotic embryos. All in vitro plantlets obtained from subcultures underwent in vitro conservation by minimal growth in low temperature (4ºC) and darkness. The efficiency of this technique was evaluated for 3, 6, and 10 months of conservation period. Maintenance in these conditions reduced micro cuttings growth. Survival and regeneration rates for each period were evaluated and resulted that the maximal time of conservation without subculture on 4ºC was 10 months, but survival and regeneration rates were significantly reduced, specifically 15.6% and 7.6%. An optimal period of conservation in these conditions can be considered the 5-6 months storage, which can lead to 60-50% of survival and regeneration rates. This protocol may be beneficial for mass propagation, mid-term conservation, and for genetic manipulation of wild almond. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=micropropagation" title="micropropagation">micropropagation</a>, <a href="https://publications.waset.org/abstracts/search?q=minimal%20growth" title=" minimal growth"> minimal growth</a>, <a href="https://publications.waset.org/abstracts/search?q=storage" title=" storage"> storage</a>, <a href="https://publications.waset.org/abstracts/search?q=wild%20almond" title=" wild almond"> wild almond</a> </p> <a href="https://publications.waset.org/abstracts/110346/micropropagation-and-in-vitro-conservation-via-slow-growth-techniques-of-prunus-webbii-spach-vierh-an-endangered-plant-species-in-albania" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/110346.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">128</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25681</span> The Links between Cardiovascular Risk and Psychological Wellbeing in Elderly</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Laura%20Sapranaviciute-Zabazlajeva">Laura Sapranaviciute-Zabazlajeva</a>, <a href="https://publications.waset.org/abstracts/search?q=Abdonas%20Tamosiunas"> Abdonas Tamosiunas</a>, <a href="https://publications.waset.org/abstracts/search?q=Dalia%20Luksiene"> Dalia Luksiene</a>, <a href="https://publications.waset.org/abstracts/search?q=Dalia%20Virviciute"> Dalia Virviciute</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The cardiovascular diseases (CVD) is the leading cause of death in the EU, especially in the middle aged and elderly population. Psychological wellbeing (PWB) has been linked with better cardiovascular health and survival in the elderly. The aim of the study is to evaluate associations between CVD risk and PWB in middle-aged and elderly population. 10,940 middle aged and older Lithuanians of age 45-74 years, were invited to participate in the study. A study sample was a random and stratified by gender and age. In 2006-2008 7,087 responders participated in the survey, so the response rate was 64.8%. A follow-up study was conducted from 2006 till 2015. New CVD cases and deaths from CVD were evaluated using the Kaunas population-based CVD register and death register of Kaunas. Study results revealed that good PWB predicts longer life in female participants (Log Rank = 13.7, p < 0.001). In the fully adjusted model for socio-demographic, social and CVD risk factors, hazard ratio for CVD mortality risk was lower amongst women with good PWB (HR = 0.28, 95% CI 0.11-0.72), but not significantly for men. Our study concludes, that lower CVD mortality rates is being associated with better PWB in female aged 45-74 years. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=psychological%20well-being" title="psychological well-being">psychological well-being</a>, <a href="https://publications.waset.org/abstracts/search?q=cardiovascular%20disease" title=" cardiovascular disease"> cardiovascular disease</a>, <a href="https://publications.waset.org/abstracts/search?q=elderly" title=" elderly"> elderly</a>, <a href="https://publications.waset.org/abstracts/search?q=survival" title=" survival"> survival</a> </p> <a href="https://publications.waset.org/abstracts/52070/the-links-between-cardiovascular-risk-and-psychological-wellbeing-in-elderly" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/52070.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">360</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25680</span> Data Transformations in Data Envelopment Analysis</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mansour%20Mohammadpour">Mansour Mohammadpour</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Data transformation refers to the modification of any point in a data set by a mathematical function. When applying transformations, the measurement scale of the data is modified. Data transformations are commonly employed to turn data into the appropriate form, which can serve various functions in the quantitative analysis of the data. This study addresses the investigation of the use of data transformations in Data Envelopment Analysis (DEA). Although data transformations are important options for analysis, they do fundamentally alter the nature of the variable, making the interpretation of the results somewhat more complex. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=data%20transformation" title="data transformation">data transformation</a>, <a href="https://publications.waset.org/abstracts/search?q=data%20envelopment%20analysis" title=" data envelopment analysis"> data envelopment analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=undesirable%20data" title=" undesirable data"> undesirable data</a>, <a href="https://publications.waset.org/abstracts/search?q=negative%20data" title=" negative data"> negative data</a> </p> <a href="https://publications.waset.org/abstracts/192236/data-transformations-in-data-envelopment-analysis" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/192236.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">20</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25679</span> Structural and Functional Characterization of the Transcriptional Regulator Rv1176 of Mycobacterium tuberculosis H37Rv</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vikash%20Yadav">Vikash Yadav</a>, <a href="https://publications.waset.org/abstracts/search?q=Ashish%20Arora"> Ashish Arora</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Microorganisms have self-defense mechanisms to protect themselves from toxic environments. Phenolic acid decarboxylase(pad) is responsible for the defense against toxicity caused by phenolic acids, converting them into less toxic vinyl derivatives. The transcription of the pad gene is regulated by a negative transcription factor, phenolic acid decarboxylase regulators (PadR), in a substrate-inducible manner. The PadR family members share the conserved DNA-binding features and interact with the operator DNA using a winged helix-turn-helix (wHTH) motif, which contains a three-helix motif and a β-stranded wing. The members of this family function as transcriptional regulators that are involved in various cellular survival processes, such as toxin production, detoxification, multidrug resistance, antibiotic biosynthesis, and carbon catabolism. Rv1176 of Mycobacterium tuberculosis H37Rv has been assigned to the PadR family protein that remains to be structurally and functionally uncharacterized. To reveal the structural mechanism by which Rv1176 could regulates effector-responsive transcription, several experiments were performed, including Electrophoretic Mobility Shift Assay (EMSA) for DNA protein interaction, differential scanning calorimetry (DSC) and Differential Scanning Fluorimetry (DSF) for temperature and ligand-dependent protein stability, Circular Dichroism (CD) spectroscopy for secondary structure analysis. Further, to evaluate the functional role of Rv1176, the intracellular survival of recombinant M. smegmatis was examined in murine macrophage cell line J774A.1 and different stressed conditions like oxidative, pH, and nutritive stress. All these studies demonstrated that Rv1176 could behave as a transcription regulator and its expression in recombinant M. smegmatis increases intracellular survival. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=EMSA" title="EMSA">EMSA</a>, <a href="https://publications.waset.org/abstracts/search?q=Mycobacterium%20tuberculosis" title=" Mycobacterium tuberculosis"> Mycobacterium tuberculosis</a>, <a href="https://publications.waset.org/abstracts/search?q=PadR%20family%20protein" title=" PadR family protein"> PadR family protein</a>, <a href="https://publications.waset.org/abstracts/search?q=transcriptional%20regulator" title=" transcriptional regulator"> transcriptional regulator</a> </p> <a href="https://publications.waset.org/abstracts/161202/structural-and-functional-characterization-of-the-transcriptional-regulator-rv1176-of-mycobacterium-tuberculosis-h37rv" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/161202.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">78</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25678</span> Q-Map: Clinical Concept Mining from Clinical Documents</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sheikh%20Shams%20Azam">Sheikh Shams Azam</a>, <a href="https://publications.waset.org/abstracts/search?q=Manoj%20Raju"> Manoj Raju</a>, <a href="https://publications.waset.org/abstracts/search?q=Venkatesh%20Pagidimarri"> Venkatesh Pagidimarri</a>, <a href="https://publications.waset.org/abstracts/search?q=Vamsi%20Kasivajjala"> Vamsi Kasivajjala</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Over the past decade, there has been a steep rise in the data-driven analysis in major areas of medicine, such as clinical decision support system, survival analysis, patient similarity analysis, image analytics etc. Most of the data in the field are well-structured and available in numerical or categorical formats which can be used for experiments directly. But on the opposite end of the spectrum, there exists a wide expanse of data that is intractable for direct analysis owing to its unstructured nature which can be found in the form of discharge summaries, clinical notes, procedural notes which are in human written narrative format and neither have any relational model nor any standard grammatical structure. An important step in the utilization of these texts for such studies is to transform and process the data to retrieve structured information from the haystack of irrelevant data using information retrieval and data mining techniques. To address this problem, the authors present Q-Map in this paper, which is a simple yet robust system that can sift through massive datasets with unregulated formats to retrieve structured information aggressively and efficiently. It is backed by an effective mining technique which is based on a string matching algorithm that is indexed on curated knowledge sources, that is both fast and configurable. The authors also briefly examine its comparative performance with MetaMap, one of the most reputed tools for medical concepts retrieval and present the advantages the former displays over the latter. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=information%20retrieval" title="information retrieval">information retrieval</a>, <a href="https://publications.waset.org/abstracts/search?q=unified%20medical%20language%20system" title=" unified medical language system"> unified medical language system</a>, <a href="https://publications.waset.org/abstracts/search?q=syntax%20based%20analysis" title=" syntax based analysis"> syntax based analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=natural%20language%20processing" title=" natural language processing"> natural language processing</a>, <a href="https://publications.waset.org/abstracts/search?q=medical%20informatics" title=" medical informatics"> medical informatics</a> </p> <a href="https://publications.waset.org/abstracts/95189/q-map-clinical-concept-mining-from-clinical-documents" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/95189.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">133</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25677</span> Effect of Bacillus Pumilus Strains on Heavy Metal Accumulation in Lettuce Grown on Contaminated Soil</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sabeen%20Alam">Sabeen Alam</a>, <a href="https://publications.waset.org/abstracts/search?q=Mehboob%20Alam"> Mehboob Alam</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The research work entitled “Effect of Bacillus pumilus strains on heavy metal accumulation in lettuce grown on contaminated soil” focused on functional role of Bacillus pumilus strains inoculated with lettuce seed in mitigating heavy metal in chromite mining soil. In this experiment, factor A was three Bacillus pumilus strains (sequence C-2PMW-8, C-1 SSK-8 and C-1 PWK-7) while soil used for this experiment was collected from Prang Ghar mining site and lettuce seeds were grown in three levels of chromite mining soil (2.27, 4.65 and 7.14 %). For mining soil minimum days to germinate noted in lettuce grown on garden soil inoculated with sequence. Maximum germination percentage noted was for C-1 SSK-8 grown on garden soil, maximum lettuce height for sequence C-2 PWM-8, fresh leaf weight for C-1 PWK-7 inoculated lettuce, dry weight of lettuce leaf for lettuce inoculated with C-1 SSK-8 and C-1 PWK-7 strains, number of leaves per plant for lettuce inoculated with C-1 SSK-8, leaf area for C-2 PMW-8 inoculated lettuce, survival percentage for C-1 SSK-8 treated lettuce and chlorophyll content for C-2 PMW-8. Results related to heavy metals accumulation showed that minimum chromium was in lettuce and in soil for all three sequences, cadmium (Cd) in lettuce and in soil for all three sequences, manganese (Mn) in lettuce and in soil for three sequences, lead (Pb) in lettuce and in soil for three sequences. It can be concluded that chromite mining soil significantly reduced the growth and survival of lettuce, but when lettuce was inoculated with Bacillus.pumilus strains, it enhances growth and survival. Similarly, minimum heavy metal accumulation in plant and soil, regardless of type of Bacillus pumilus used, all three sequences has same mitigating effect on heavy metal in both soil and lettuce. All the three Bacillus pumilus strains ensured reduction in heavy metals content (Mn, Cd, Cr) in lettuce, below the maximum permissible limits of WHO 2011. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=bacillus%20pumilus" title="bacillus pumilus">bacillus pumilus</a>, <a href="https://publications.waset.org/abstracts/search?q=heavy%20metals" title=" heavy metals"> heavy metals</a>, <a href="https://publications.waset.org/abstracts/search?q=permissible%20limits" title=" permissible limits"> permissible limits</a>, <a href="https://publications.waset.org/abstracts/search?q=lettuce" title=" lettuce"> lettuce</a>, <a href="https://publications.waset.org/abstracts/search?q=chromite%20mining%20soil" title=" chromite mining soil"> chromite mining soil</a>, <a href="https://publications.waset.org/abstracts/search?q=mitigating%20effect" title=" mitigating effect"> mitigating effect</a> </p> <a href="https://publications.waset.org/abstracts/181677/effect-of-bacillus-pumilus-strains-on-heavy-metal-accumulation-in-lettuce-grown-on-contaminated-soil" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/181677.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">59</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25676</span> The Biological Function and Clinical Significance of Long Non-coding RNA LINC AC008063 in Head and Neck Squamous Carcinoma</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Maierhaba%20Mijiti">Maierhaba Mijiti</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Objective：The aim is to understand the relationship between the expression level of the long-non-coding RNA LINC AC008063 and the clinicopathological parameters of patients with head and neck squamous cell carcinoma (HNSCC), and to clarify the biological function of LINC AC008063 in HNSCC cells. Moreover, it provides a potential biomarker for the diagnosis, treatment, and prognosis evaluation of HNSCC. Methods: The expression level of LINC AC008063 in the HNSCC was analyzed using transcriptome sequencing data from the TCGA (The cancer genome atlas) database. The expression levels of LINC AC008063 in human embryonic lung diploid cells 2BS, human immortalized keratinocytes HACAT, HNSCC cell lines CAL-27, Detroit562, AMC-HN-8, FD-LSC-1, FaDu and WSU-HN30 were determined by real-time quantitative PCR (qPCR). RNAi (RNA interference) was introduced for LINC AC008063 knockdown in HNSCC cell lines, the localization and abundance analysis of LINC AC008063 was determined by RT-qPCR, and the biological functions were examined by CCK-8, clone formation, flow cytometry, transwell invasion and migration assays, Seahorse assay. Results: LINC AC008063 was upregulated in HNSCC tissue (P<0.001), and verified b CCK-8, clone formation, flow cytometry, transwell invasion and migration assays, Seahorse assayy qPCR in HNSCC cell lines. The survival analysis revealed that the overall survival rate (OS) of patients with high LINC AC008063 expression group was significantly lower than that in the LINC AC008063 expression group, the median survival times for the two groups were 33.10 months and 61.27 months, respectively (P=0.002). The clinical correlation analysis revealed that its expression was positively correlated with the age of patients with HNSCC (P<0.001) and positively correlated with pathological state (T3+T4＞T1+T2, P=0.03). The RT-qPCR results showed that LINC AC008063 was mainly enriched in cytoplasm (P=0.01). Knockdown of LINC AC008063 inhibited proliferation, colony formation, migration and invasion; the glycolytic capacity was significantly decreased in HNSCC cell lines (P＜0.05). Conclusion: High level of LINC AC008063 was associated with the malignant progression of HNSCC as well as promoting the important biological functions of proliferation, colony formation, migration and invasion; in particular, the glycolytic capacity was decreased in HNSCC cells. Therefore, LINC AC008063 may serve as a potential biomarker for HNSCC and a distinct molecular target to inhibit glycolysis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=head%20and%20neck%20squamous%20cell%20carcinoma" title="head and neck squamous cell carcinoma">head and neck squamous cell carcinoma</a>, <a href="https://publications.waset.org/abstracts/search?q=oncogene" title=" oncogene"> oncogene</a>, <a href="https://publications.waset.org/abstracts/search?q=long%20non-coding%20RNA" title=" long non-coding RNA"> long non-coding RNA</a>, <a href="https://publications.waset.org/abstracts/search?q=LINC%20AC008063" title=" LINC AC008063"> LINC AC008063</a>, <a href="https://publications.waset.org/abstracts/search?q=invasion%20and%20metastasis" title=" invasion and metastasis"> invasion and metastasis</a> </p> <a href="https://publications.waset.org/abstracts/194321/the-biological-function-and-clinical-significance-of-long-non-coding-rna-linc-ac008063-in-head-and-neck-squamous-carcinoma" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/194321.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">11</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25675</span> Application Difference between Cox and Logistic Regression Models</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Idrissa%20Kayijuka">Idrissa Kayijuka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The logistic regression and Cox regression models (proportional hazard model) at present are being employed in the analysis of prospective epidemiologic research looking into risk factors in their application on chronic diseases. However, a theoretical relationship between the two models has been studied. By definition, Cox regression model also called Cox proportional hazard model is a procedure that is used in modeling data regarding time leading up to an event where censored cases exist. Whereas the Logistic regression model is mostly applicable in cases where the independent variables consist of numerical as well as nominal values while the resultant variable is binary (dichotomous). Arguments and findings of many researchers focused on the overview of Cox and Logistic regression models and their different applications in different areas. In this work, the analysis is done on secondary data whose source is SPSS exercise data on BREAST CANCER with a sample size of 1121 women where the main objective is to show the application difference between Cox regression model and logistic regression model based on factors that cause women to die due to breast cancer. Thus we did some analysis manually i.e. on lymph nodes status, and SPSS software helped to analyze the mentioned data. This study found out that there is an application difference between Cox and Logistic regression models which is Cox regression model is used if one wishes to analyze data which also include the follow-up time whereas Logistic regression model analyzes data without follow-up-time. Also, they have measurements of association which is different: hazard ratio and odds ratio for Cox and logistic regression models respectively. A similarity between the two models is that they are both applicable in the prediction of the upshot of a categorical variable i.e. a variable that can accommodate only a restricted number of categories. In conclusion, Cox regression model differs from logistic regression by assessing a rate instead of proportion. The two models can be applied in many other researches since they are suitable methods for analyzing data but the more recommended is the Cox, regression model. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=logistic%20regression%20model" title="logistic regression model">logistic regression model</a>, <a href="https://publications.waset.org/abstracts/search?q=Cox%20regression%20model" title=" Cox regression model"> Cox regression model</a>, <a href="https://publications.waset.org/abstracts/search?q=survival%20analysis" title=" survival analysis"> survival analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=hazard%20ratio" title=" hazard ratio"> hazard ratio</a> </p> <a href="https://publications.waset.org/abstracts/66111/application-difference-between-cox-and-logistic-regression-models" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/66111.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">455</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25674</span> Applying an Application-Based Knowledge Capturing and Reusing for Construction Consultant Organizations Applying</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Phan%20Nghiem%20Vu">Phan Nghiem Vu</a>, <a href="https://publications.waset.org/abstracts/search?q=Le%20Tuan%20Vu"> Le Tuan Vu</a>, <a href="https://publications.waset.org/abstracts/search?q=Ta%20Quang%20Tai"> Ta Quang Tai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Knowledge Management effectively is critical to the survival and advance of a company, especially in company-based industries such as construction. Knowledge management practice is crucial to the survival and progress of a company, especially company-based knowledge such as construction consultancy. Effective knowledge management practices are very significant to the competitive and development of a consulting organization. Hence, the success of knowledge management implementation depends on knowledge capturing and reusing effectively. In this paper, a survey was carried out of engineers and managers with experience in seven construction consulting organizations that provide services on the north-central coast of Vietnam. The main objectives of the survey to finding out how these organizations capture and reuse knowledge and significant barriers to the implementation of knowledge management. A conceptual framework based-on Trello application is proposed to formalize the knowledge-capturing and reusing process within construction consulting companies. It is showed that the conceptual framework could be used to manage both implicit and explicit knowledge effectively in construction consultant organizations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=knowledge%20management" title="knowledge management">knowledge management</a>, <a href="https://publications.waset.org/abstracts/search?q=construction%20consultant%20organization" title=" construction consultant organization"> construction consultant organization</a>, <a href="https://publications.waset.org/abstracts/search?q=knowledge%20capturing" title=" knowledge capturing"> knowledge capturing</a>, <a href="https://publications.waset.org/abstracts/search?q=reusing%20knowledge" title=" reusing knowledge"> reusing knowledge</a>, <a href="https://publications.waset.org/abstracts/search?q=application-based%20technology" title=" application-based technology"> application-based technology</a> </p> <a href="https://publications.waset.org/abstracts/116128/applying-an-application-based-knowledge-capturing-and-reusing-for-construction-consultant-organizations-applying" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/116128.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">130</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25673</span> Analysis of Photic Zone’s Summer Period-Dissolved Oxygen and Temperature as an Early Warning System of Fish Mass Mortality in Sampaloc Lake in San Pablo, Laguna</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Al%20Romano">Al Romano</a>, <a href="https://publications.waset.org/abstracts/search?q=Jeryl%20C.%20Hije"> Jeryl C. Hije</a>, <a href="https://publications.waset.org/abstracts/search?q=Mechaela%20Marie%20O.%20Tabiolo"> Mechaela Marie O. Tabiolo</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The decline in water quality is a major factor in aquatic disease outbreaks and can lead to significant mortality among aquatic organisms. Understanding the relationship between dissolved oxygen (DO) and water temperature is crucial, as these variables directly impact the health, behavior, and survival of fish populations. This study investigated how DO levels, water temperature, and atmospheric temperature interact in Sampaloc Lake to assess the risk of fish mortality. By employing a combination of linear regression models and machine learning techniques, researchers developed predictive models to forecast DO concentrations at various depths. The results indicate that while DO levels generally decrease with depth, the predicted concentrations are sufficient to support the survival of common fish species in Sampaloc Lake during March, April, and May 2025. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aquaculture" title="aquaculture">aquaculture</a>, <a href="https://publications.waset.org/abstracts/search?q=dissolved%20oxygen" title=" dissolved oxygen"> dissolved oxygen</a>, <a href="https://publications.waset.org/abstracts/search?q=water%20temperature" title=" water temperature"> water temperature</a>, <a href="https://publications.waset.org/abstracts/search?q=regression%20analysis" title=" regression analysis"> regression analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=machine%20learning" title=" machine learning"> machine learning</a>, <a href="https://publications.waset.org/abstracts/search?q=fish%20mass%20mortality" title=" fish mass mortality"> fish mass mortality</a>, <a href="https://publications.waset.org/abstracts/search?q=early%20warning%20system" title=" early warning system"> early warning system</a> </p> <a href="https://publications.waset.org/abstracts/189671/analysis-of-photic-zones-summer-period-dissolved-oxygen-and-temperature-as-an-early-warning-system-of-fish-mass-mortality-in-sampaloc-lake-in-san-pablo-laguna" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/189671.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">35</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25672</span> Marginalized Two-Part Joint Models for Generalized Gamma Family of Distributions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mohadeseh%20Shojaei%20Shahrokhabadi">Mohadeseh Shojaei Shahrokhabadi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ding-Geng%20%28Din%29%20Chen"> Ding-Geng (Din) Chen</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Positive continuous outcomes with a substantial number of zero values and incomplete longitudinal follow-up are quite common in medical cost data. To jointly model semi-continuous longitudinal cost data and survival data and to provide marginalized covariate effect estimates, a marginalized two-part joint model (MTJM) has been developed for outcome variables with lognormal distributions. In this paper, we propose MTJM models for outcome variables from a generalized gamma (GG) family of distributions. The GG distribution constitutes a general family that includes approximately all of the most frequently used distributions like the Gamma, Exponential, Weibull, and Log Normal. In the proposed MTJM-GG model, the conditional mean from a conventional two-part model with a three-parameter GG distribution is parameterized to provide the marginal interpretation for regression coefficients. In addition, MTJM-gamma and MTJM-Weibull are developed as special cases of MTJM-GG. To illustrate the applicability of the MTJM-GG, we applied the model to a set of real electronic health record data recently collected in Iran, and we provided SAS code for application. The simulation results showed that when the outcome distribution is unknown or misspecified, which is usually the case in real data sets, the MTJM-GG consistently outperforms other models. The GG family of distribution facilitates estimating a model with improved fit over the MTJM-gamma, standard Weibull, or Log-Normal distributions. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=marginalized%20two-part%20model" title="marginalized two-part model">marginalized two-part model</a>, <a href="https://publications.waset.org/abstracts/search?q=zero-inflated" title=" zero-inflated"> zero-inflated</a>, <a href="https://publications.waset.org/abstracts/search?q=right-skewed" title=" right-skewed"> right-skewed</a>, <a href="https://publications.waset.org/abstracts/search?q=semi-continuous" title=" semi-continuous"> semi-continuous</a>, <a href="https://publications.waset.org/abstracts/search?q=generalized%20gamma" title=" generalized gamma"> generalized gamma</a> </p> <a href="https://publications.waset.org/abstracts/140917/marginalized-two-part-joint-models-for-generalized-gamma-family-of-distributions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/140917.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">176</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">25671</span> Therapeutic Effects of Toll Like Receptor 9 Ligand CpG-ODN on Radiation Injury</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Jianming%20Cai">Jianming Cai</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Exposure to ionizing radiation causes severe damage to human body and an safe and effective radioprotector is urgently required for alleviating radiation damage. In 2008, flagellin, an agonist of TLR5, was found to exert radioprotective effects on radiation injury through activating NF-kB signaling pathway. From then, the radioprotective effects of TLR ligands has shed new lights on radiation protection. CpG-ODN is an unmethylated oligonucleotide which activates TLR9 signaling pathway. In this study, we demonstrated that CpG-ODN has therapeutic effects on radiation injuries induced by γ ray and 12C6+ heavy ion particles. Our data showed that CpG-ODN increased the survival rate of mice after whole body irradiation and increased the number of leukocytes as well as the bone marrow cells. CpG-ODN also alleviated radiation damage on intestinal crypt through regulating apoptosis signaling pathway including bcl2, bax, and caspase 3 etc. By using a radiation-induced pulmonary fibrosis model, we found that CpG-ODN could alleviate structural damage, within 20 week after whole–thorax 15Gy irradiation. In this model, Th1/Th2 imbalance induced by irradiation was also reversed by CpG-ODN. We also found that TGFβ-Smad signaling pathway was regulated by CpG-ODN, which accounts for the therapeutic effects of CpG-ODN in radiation-induced pulmonary injury. On another hand, for high LET radiation protection, we investigated protective effects of CpG-ODN against 12C6+ heavy ion irradiation and found that after CpG-ODN treatment, the apoptosis and cell cycle arrest induced by 12C6+ irradiation was reduced. CpG-ODN also reduced the expression of Bax and caspase 3, while increased the level of bcl2. Then we detected the effect of CpG-ODN on heavy ion induced immune dysfunction. Our data showed that CpG-ODN increased the survival rate of mice and also the leukocytes after 12C6+ irradiation. Besides, the structural damage of immune organ such as thymus and spleen was also alleviated by CpG-ODN treatment. In conclusion, we found that TLR9 ligand, CpG-ODN reduced radiation injuries in response to γ ray and 12C6+ heavy ion irradiation. On one hand, CpG-ODN inhibited the activation of apoptosis induced by radiation through regulating bcl2, bax and caspase 3. On another hand, through activating TLR9, CpG-ODN recruit MyD88-IRAK-TRAF6 complex, activating TAK1, IRF5 and NF-kB pathway, and thus alleviates radiation damage. This study provides novel insights into protection and therapy of radiation damages. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=TLR9" title="TLR9">TLR9</a>, <a href="https://publications.waset.org/abstracts/search?q=CpG-ODN" title=" CpG-ODN"> CpG-ODN</a>, <a href="https://publications.waset.org/abstracts/search?q=radiation%20injury" title=" radiation injury"> radiation injury</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20LET%20radiation" title=" high LET radiation"> high LET radiation</a> </p> <a href="https://publications.waset.org/abstracts/35124/therapeutic-effects-of-toll-like-receptor-9-ligand-cpg-odn-on-radiation-injury" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/35124.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">480</span> 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