CINXE.COM

<!DOCTYPE html> <html > <head> <meta charset="utf-8"> <meta rel="search" type="application/opensearchdescription+xml" href="/open_search.xml" title="Academia.edu"> <meta content="width=device-width, initial-scale=1" name="viewport"> <meta name="google-site-verification" content="bKJMBZA7E43xhDOopFZkssMMkBRjvYERV-NaN4R6mrs"> <meta name="csrf-param" content="authenticity_token" /> <meta name="csrf-token" content="Xt4Y4txHgHMcJ6kQaJ4s7vpE5+NgSfaHPZ4EUFrN1pzWegUGltxd9Ch7pN3v9flnL2gIUdncUPtEvjY/peaNxg==" /> <meta name="citation_title" content="Dinámica mitocondrial en las enfermedades neurodegenerativas" /> <meta name="citation_publication_date" content="2019" /> <meta name="citation_journal_title" content="Gaceta Médica de México" /> <meta name="citation_author" content="Adriana Alarcón-Aguilar" /> <meta name="citation_author" content="Paola Maycotte-González" /> <meta name="citation_author" content="Paulina Cortés-Hernández" /> <meta name="citation_author" content="Norma Edith López-Diazguerrero" /> <meta name="citation_author" content="Mina Königsberg" /> <meta name="citation_volume" content="155" /> <meta name="citation_issue" content="3" /> <meta name="citation_issn" content="0016-3813" /> <meta name="twitter:card" content="summary" /> <meta name="twitter:url" content="https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas" /> <meta name="twitter:title" content="Dinámica mitocondrial en las enfermedades neurodegenerativas" /> <meta name="twitter:description" content="Las enfermedades neurodegenerativas son un grupo heterogéneo caracterizado por la disminución gradual, progresiva y selectiva de las funciones del sistema nervioso. La etiología de estas patologías aún se desconoce, sin embargo, se ha propuesto que" /> <meta name="twitter:image" content="http://a.academia-assets.com/images/twitter-card.jpeg" /> <meta property="fb:app_id" content="2369844204" /> <meta property="og:type" content="article" /> <meta property="og:url" content="https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas" /> <meta property="og:title" content="Dinámica mitocondrial en las enfermedades neurodegenerativas" /> <meta property="og:image" content="http://a.academia-assets.com/images/open-graph-icons/fb-paper.gif" /> <meta property="og:description" content="Las enfermedades neurodegenerativas son un grupo heterogéneo caracterizado por la disminución gradual, progresiva y selectiva de las funciones del sistema nervioso. La etiología de estas patologías aún se desconoce, sin embargo, se ha propuesto que" /> <meta property="article:author" content="https://independent.academia.edu/MinaK%C3%B6nigsberg" /> <meta name="description" content="Las enfermedades neurodegenerativas son un grupo heterogéneo caracterizado por la disminución gradual, progresiva y selectiva de las funciones del sistema nervioso. La etiología de estas patologías aún se desconoce, sin embargo, se ha propuesto que" /> <title>(PDF) Dinámica mitocondrial en las enfermedades neurodegenerativas</title> <link rel="canonical" href="https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas" /> <script async src="https://www.googletagmanager.com/gtag/js?id=G-5VKX33P2DS"></script> <script> window.dataLayer = window.dataLayer || []; function gtag(){dataLayer.push(arguments);} gtag('js', new Date()); gtag('config', 'G-5VKX33P2DS', { cookie_domain: 'academia.edu', send_page_view: false, }); gtag('event', 'page_view', { 'controller': "single_work", 'action': "show", 'controller_action': 'single_work#show', 'logged_in': 'false', 'edge': 'unknown', // Send nil if there is no A/B test bucket, in case some records get logged // with missing data - that way we can distinguish between the two cases. // ab_test_bucket should be of the form <ab_test_name>:<bucket> 'ab_test_bucket': null, }) </script> <script> var $controller_name = 'single_work'; var $action_name = "show"; var $rails_env = 'production'; var $app_rev = 'e4aaa77f54406eebb1468586fc8789d2b4836e07'; var $domain = 'academia.edu'; var $app_host = "academia.edu"; var $asset_host = "academia-assets.com"; var $start_time = new Date().getTime(); var $recaptcha_key = "6LdxlRMTAAAAADnu_zyLhLg0YF9uACwz78shpjJB"; var $recaptcha_invisible_key = "6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj"; var $disableClientRecordHit = false; </script> <script> window.require = { config: function() { return function() {} } } </script> <script> window.Aedu = window.Aedu || {}; window.Aedu.hit_data = null; window.Aedu.serverRenderTime = new Date(1736137983000); window.Aedu.timeDifference = new Date().getTime() - 1736137983000; </script> <script type="application/ld+json">{"@context":"https://schema.org","@type":"ScholarlyArticle","author":[{"@context":"https://schema.org","@type":"Person","name":"Mina Königsberg"}],"contributor":[],"dateCreated":"2021-12-29","dateModified":"2024-11-24","headline":"Dinámica mitocondrial en las enfermedades neurodegenerativas","image":"https://attachments.academia-assets.com/77644669/thumbnails/1.jpg","inLanguage":"es","keywords":["Biology","Medicine"],"publication":"Gaceta de M�xico","publisher":{"@context":"https://schema.org","@type":"Organization","name":"Publicidad Permanyer, SLU"},"sourceOrganization":[{"@context":"https://schema.org","@type":"EducationalOrganization","name":null}],"thumbnailUrl":"https://attachments.academia-assets.com/77644669/thumbnails/1.jpg","url":"https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas"}</script><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/single_work_page/loswp-69556be8c73b29a575811f97c49ddc0244a4f6ac5828c168fca4a6cd6c8f069b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/body-8d679e925718b5e8e4b18e9a4fab37f7eaa99e43386459376559080ac8f2856a.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/button-3cea6e0ad4715ed965c49bfb15dedfc632787b32ff6d8c3a474182b231146ab7.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/heading-b2b823dd904da60a48fd1bfa1defd840610c2ff414d3f39ed3af46277ab8df3b.css" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/text_button-73590134e40cdb49f9abdc8e796cc00dc362693f3f0f6137d6cf9bb78c318ce7.css" /><link crossorigin="" href="https://fonts.gstatic.com/" rel="preconnect" /><link href="https://fonts.googleapis.com/css2?family=DM+Sans:ital,opsz,wght@0,9..40,100..1000;1,9..40,100..1000&family=Gupter:wght@400;500;700&family=IBM+Plex+Mono:wght@300;400&family=Material+Symbols+Outlined:opsz,wght,FILL,GRAD@20,400,0,0&display=swap" rel="stylesheet" /><link rel="stylesheet" media="all" href="//a.academia-assets.com/assets/design_system/common-2b6f90dbd75f5941bc38f4ad716615f3ac449e7398313bb3bc225fba451cd9fa.css" /> </head> <body> <div id='react-modal'></div> <div class="js-upgrade-ie-banner" style="display: none; text-align: center; padding: 8px 0; background-color: #ebe480;"><p style="color: #000; font-size: 12px; margin: 0 0 4px;">Academia.edu no longer supports Internet Explorer.</p><p style="color: #000; font-size: 12px; margin: 0;">To browse Academia.edu and the wider internet faster and more securely, please take a few seconds to <a href="https://www.academia.edu/upgrade-browser">upgrade your browser</a>.</p></div><script>// Show this banner for all versions of IE if (!!window.MSInputMethodContext || /(MSIE)/.test(navigator.userAgent)) { document.querySelector('.js-upgrade-ie-banner').style.display = 'block'; }</script> <div class="bootstrap login"><div class="modal fade login-modal" id="login-modal"><div class="login-modal-dialog modal-dialog"><div class="modal-content"><div class="modal-header"><button class="close close" data-dismiss="modal" type="button"><span aria-hidden="true">×</span><span class="sr-only">Close</span></button><h4 class="modal-title text-center"><strong>Log In</strong></h4></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><button class="btn btn-fb btn-lg btn-block btn-v-center-content" id="login-facebook-oauth-button"><svg style="float: left; width: 19px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="facebook-square" class="svg-inline--fa fa-facebook-square fa-w-14" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 448 512"><path fill="currentColor" d="M400 32H48A48 48 0 0 0 0 80v352a48 48 0 0 0 48 48h137.25V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.27c-30.81 0-40.42 19.12-40.42 38.73V256h68.78l-11 71.69h-57.78V480H400a48 48 0 0 0 48-48V80a48 48 0 0 0-48-48z"></path></svg><small><strong>Log in</strong> with <strong>Facebook</strong></small></button><br /><button class="btn btn-google btn-lg btn-block btn-v-center-content" id="login-google-oauth-button"><svg style="float: left; width: 22px; line-height: 1em; margin-right: .3em;" aria-hidden="true" focusable="false" data-prefix="fab" data-icon="google-plus" class="svg-inline--fa fa-google-plus fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M256,8C119.1,8,8,119.1,8,256S119.1,504,256,504,504,392.9,504,256,392.9,8,256,8ZM185.3,380a124,124,0,0,1,0-248c31.3,0,60.1,11,83,32.3l-33.6,32.6c-13.2-12.9-31.3-19.1-49.4-19.1-42.9,0-77.2,35.5-77.2,78.1S142.3,334,185.3,334c32.6,0,64.9-19.1,70.1-53.3H185.3V238.1H302.2a109.2,109.2,0,0,1,1.9,20.7c0,70.8-47.5,121.2-118.8,121.2ZM415.5,273.8v35.5H380V273.8H344.5V238.3H380V202.8h35.5v35.5h35.2v35.5Z"></path></svg><small><strong>Log in</strong> with <strong>Google</strong></small></button><br /><style type="text/css">.sign-in-with-apple-button { width: 100%; height: 52px; border-radius: 3px; border: 1px solid black; cursor: pointer; }</style><script src="https://appleid.cdn-apple.com/appleauth/static/jsapi/appleid/1/en_US/appleid.auth.js" type="text/javascript"></script><div class="sign-in-with-apple-button" data-border="false" data-color="white" id="appleid-signin"><span   ="Sign Up with Apple" class="u-fs11"></span></div><script>AppleID.auth.init({ clientId: 'edu.academia.applesignon', scope: 'name email', redirectURI: 'https://www.academia.edu/sessions', state: "70036c18a7e76c55085fa28f1e20f8e8cd67420ac0f62ea393fd53521fbd834f", });</script><script>// Hacky way of checking if on fast loswp if (window.loswp == null) { (function() { const Google = window?.Aedu?.Auth?.OauthButton?.Login?.Google; const Facebook = window?.Aedu?.Auth?.OauthButton?.Login?.Facebook; if (Google) { new Google({ el: '#login-google-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } if (Facebook) { new Facebook({ el: '#login-facebook-oauth-button', rememberMeCheckboxId: 'remember_me', track: null }); } })(); }</script></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><div class="hr-heading login-hr-heading"><span class="hr-heading-text">or</span></div></div></div></div><div class="modal-body"><div class="row"><div class="col-xs-10 col-xs-offset-1"><form class="js-login-form" action="https://www.academia.edu/sessions" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="7iqGF3s3jkkMMXIufa3pbciRWnmi3T9mBg4UsMmMFoxmjpvzMaxTzjhtf+P6xjzkHb21yxtImRp/LibfNqdN1g==" autocomplete="off" /><div class="form-group"><label class="control-label" for="login-modal-email-input" style="font-size: 14px;">Email</label><input class="form-control" id="login-modal-email-input" name="login" type="email" /></div><div class="form-group"><label class="control-label" for="login-modal-password-input" style="font-size: 14px;">Password</label><input class="form-control" id="login-modal-password-input" name="password" type="password" /></div><input type="hidden" name="post_login_redirect_url" id="post_login_redirect_url" value="https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas" autocomplete="off" /><div class="checkbox"><label><input type="checkbox" name="remember_me" id="remember_me" value="1" checked="checked" /><small style="font-size: 12px; margin-top: 2px; display: inline-block;">Remember me on this computer</small></label></div><br><input type="submit" name="commit" value="Log In" class="btn btn-primary btn-block btn-lg js-login-submit" data-disable-with="Log In" /></br></form><script>typeof window?.Aedu?.recaptchaManagedForm === 'function' && window.Aedu.recaptchaManagedForm( document.querySelector('.js-login-form'), document.querySelector('.js-login-submit') );</script><small style="font-size: 12px;"><br />or <a data-target="#login-modal-reset-password-container" data-toggle="collapse" href="javascript:void(0)">reset password</a></small><div class="collapse" id="login-modal-reset-password-container"><br /><div class="well margin-0x"><form class="js-password-reset-form" action="https://www.academia.edu/reset_password" accept-charset="UTF-8" method="post"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><input type="hidden" name="authenticity_token" value="0J4+ffdX1V9xog1Um8L2T3y4r/pwjzDh2sD9iaulZqZYOiOZvcwI2EX+AJkcqSPGqZRASMkalp2j4M/mVI49/A==" autocomplete="off" /><p>Enter the email address you signed up with and we'll email you a reset link.</p><div class="form-group"><input class="form-control" name="email" type="email" /></div><input class="btn btn-primary btn-block g-recaptcha js-password-reset-submit" data-sitekey="6Lf3KHUUAAAAACggoMpmGJdQDtiyrjVlvGJ6BbAj" type="submit" value="Email me a link" /></form></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/collapse-45805421cf446ca5adf7aaa1935b08a3a8d1d9a6cc5d91a62a2a3a00b20b3e6a.js"], function() { // from javascript_helper.rb $("#login-modal-reset-password-container").on("shown.bs.collapse", function() { $(this).find("input[type=email]").focus(); }); }); </script> </div></div></div><div class="modal-footer"><div class="text-center"><small style="font-size: 12px;">Need an account? <a rel="nofollow" href="https://www.academia.edu/signup">Click here to sign up</a></small></div></div></div></div></div></div><script>// If we are on subdomain or non-bootstrapped page, redirect to login page instead of showing modal (function(){ if (typeof $ === 'undefined') return; var host = window.location.hostname; if ((host === $domain || host === "www."+$domain) && (typeof $().modal === 'function')) { $("#nav_log_in").click(function(e) { // Don't follow the link and open the modal e.preventDefault(); $("#login-modal").on('shown.bs.modal', function() { $(this).find("#login-modal-email-input").focus() }).modal('show'); }); } })()</script> <div id="fb-root"></div><script>window.fbAsyncInit = function() { FB.init({ appId: "2369844204", version: "v8.0", status: true, cookie: true, xfbml: true }); // Additional initialization code. if (window.InitFacebook) { // facebook.ts already loaded, set it up. window.InitFacebook(); } else { // Set a flag for facebook.ts to find when it loads. window.academiaAuthReadyFacebook = true; } };</script> <div id="google-root"></div><script>window.loadGoogle = function() { if (window.InitGoogle) { // google.ts already loaded, set it up. window.InitGoogle("331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"); } else { // Set a flag for google.ts to use when it loads. window.GoogleClientID = "331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b"; } };</script> <div class="header--container" id="main-header-container"><div class="header--inner-container header--inner-container-ds2"><div class="header-ds2--left-wrapper"><div class="header-ds2--left-wrapper-inner"><a data-main-header-link-target="logo_home" href="https://www.academia.edu/"><img class="hide-on-desktop-redesign" style="height: 24px; width: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015-A.svg" width="24" height="24" /><img width="145.2" height="18" class="hide-on-mobile-redesign" style="height: 24px;" alt="Academia.edu" src="//a.academia-assets.com/images/academia-logo-redesign-2015.svg" /></a><div class="header--search-container header--search-container-ds2"><form class="js-SiteSearch-form select2-no-default-pills" action="https://www.academia.edu/search" accept-charset="UTF-8" method="get"><input name="utf8" type="hidden" value="✓" autocomplete="off" /><svg style="width: 14px; height: 14px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="search" class="header--search-icon svg-inline--fa fa-search fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M505 442.7L405.3 343c-4.5-4.5-10.6-7-17-7H372c27.6-35.3 44-79.7 44-128C416 93.1 322.9 0 208 0S0 93.1 0 208s93.1 208 208 208c48.3 0 92.7-16.4 128-44v16.3c0 6.4 2.5 12.5 7 17l99.7 99.7c9.4 9.4 24.6 9.4 33.9 0l28.3-28.3c9.4-9.4 9.4-24.6.1-34zM208 336c-70.7 0-128-57.2-128-128 0-70.7 57.2-128 128-128 70.7 0 128 57.2 128 128 0 70.7-57.2 128-128 128z"></path></svg><input class="header--search-input header--search-input-ds2 js-SiteSearch-form-input" data-main-header-click-target="search_input" name="q" placeholder="Search" type="text" /></form></div></div></div><nav class="header--nav-buttons header--nav-buttons-ds2 js-main-nav"><button class="ds2-5-button ds2-5-button--secondary js-header-login-url header-button-ds2 header-login-ds2 hide-on-mobile-redesign react-login-modal-opener" data-signup-modal="{"location":"login-button--header"}" rel="nofollow">Log In</button><button class="ds2-5-button ds2-5-button--secondary header-button-ds2 hide-on-mobile-redesign react-login-modal-opener" data-signup-modal="{"location":"signup-button--header"}" rel="nofollow">Sign Up</button><button class="header--hamburger-button header--hamburger-button-ds2 hide-on-desktop-redesign js-header-hamburger-button"><div class="icon-bar"></div><div class="icon-bar" style="margin-top: 4px;"></div><div class="icon-bar" style="margin-top: 4px;"></div></button></nav></div><ul class="header--dropdown-container js-header-dropdown"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/login" rel="nofollow">Log In</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/signup" rel="nofollow">Sign Up</a></li><li class="header--dropdown-row js-header-dropdown-expand-button"><button class="header--dropdown-button">more<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-down" class="header--dropdown-button-icon svg-inline--fa fa-caret-down fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M31.3 192h257.3c17.8 0 26.7 21.5 14.1 34.1L174.1 354.8c-7.8 7.8-20.5 7.8-28.3 0L17.2 226.1C4.6 213.5 13.5 192 31.3 192z"></path></svg></button></li><li><ul class="header--expanded-dropdown-container"><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/about">About</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/press">Press</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/documents">Papers</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/terms">Terms</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/privacy">Privacy</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/copyright">Copyright</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://www.academia.edu/hiring"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="header--dropdown-row-icon svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg>We're Hiring!</a></li><li class="header--dropdown-row"><a class="header--dropdown-link" href="https://support.academia.edu/"><svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="header--dropdown-row-icon svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg>Help Center</a></li><li class="header--dropdown-row js-header-dropdown-collapse-button"><button class="header--dropdown-button">less<svg aria-hidden="true" focusable="false" data-prefix="fas" data-icon="caret-up" class="header--dropdown-button-icon svg-inline--fa fa-caret-up fa-w-10" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 320 512"><path fill="currentColor" d="M288.662 352H31.338c-17.818 0-26.741-21.543-14.142-34.142l128.662-128.662c7.81-7.81 20.474-7.81 28.284 0l128.662 128.662c12.6 12.599 3.676 34.142-14.142 34.142z"></path></svg></button></li></ul></li></ul></div> <script src="//a.academia-assets.com/assets/webpack_bundles/fast_loswp-bundle-4c8e25a99da9a27d4c803fb15cd1b236a45edbfddbf69fb53dba19129f92a5c7.js" defer="defer"></script><script>window.loswp = {}; window.loswp.author = 44799785; window.loswp.bulkDownloadFilterCounts = {}; window.loswp.hasDownloadableAttachment = true; window.loswp.hasViewableAttachments = true; // TODO: just use routes for this window.loswp.loginUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F66463843%2FDin%25C3%25A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas%3Fauto%3Ddownload"; window.loswp.translateUrl = "https://www.academia.edu/login?post_login_redirect_url=https%3A%2F%2Fwww.academia.edu%2F66463843%2FDin%25C3%25A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas%3Fshow_translation%3Dtrue"; window.loswp.previewableAttachments = [{"id":77644669,"identifier":"Attachment_77644669","shouldShowBulkDownload":false}]; window.loswp.shouldDetectTimezone = true; window.loswp.shouldShowBulkDownload = true; window.loswp.showSignupCaptcha = false window.loswp.willEdgeCache = false; window.loswp.work = {"work":{"id":66463843,"created_at":"2021-12-29T18:02:43.381-08:00","from_world_paper_id":189725821,"updated_at":"2024-11-24T02:30:58.947-08:00","_data":{"publisher":"Publicidad Permanyer, SLU","grobid_abstract":"Las enfermedades neurodegenerativas son un grupo heterogéneo caracterizado por la disminución gradual, progresiva y selectiva de las funciones del sistema nervioso. La etiología de estas patologías aún se desconoce, sin embargo, se ha propuesto que la función mitocondrial pudiese estar participando en el establecimiento de estas enfermedades, debido al alto requerimiento energético que tienen las neuronas para realizar sus funciones fisiológicas. La mitocondria es un organelo dinámico que puede cambiar su morfología y función en respuesta a diferentes estímulos fisiológicos, por ello se ha empezado a estudiar a la dinámica mitocondrial como uno de los principales reguladores de la supervivencia celular. Este evento comprende diferentes procesos como la generación de nuevas mitocondrias y su eliminación cuando ya no son funcionales, así como los procesos de fusión y fisión mitocondrial y el tráfico de estos organelos en el entorno celular. Todos estos procesos son altamente regulados y tienen como finalidad la óptima funcionalidad de la mitocondria y la homeostasis celular.","publication_name":"Gaceta de M�xico","grobid_abstract_attachment_id":"77644669"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"es","title":"Dinámica mitocondrial en las enfermedades neurodegenerativas","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [44799785]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "full_page_mobile_sutd_modal"; window.loswp.useOptimizedScribd4genScript = false; window.loginModal = {}; window.loginModal.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div class="ds-loswp-container"><div class="ds-work-card--grid-container"><div class="ds-work-card--container js-loswp-work-card"><div class="ds-work-card--cover"><div class="ds-work-cover--wrapper"><div class="ds-work-cover--container"><button class="ds-work-cover--clickable js-swp-download-button" data-signup-modal="{"location":"swp-splash-paper-cover","attachmentId":77644669,"attachmentType":"pdf"}"><img alt="First page of “Dinámica mitocondrial en las enfermedades neurodegenerativas”" class="ds-work-cover--cover-thumbnail" src="https://0.academia-photos.com/attachment_thumbnails/77644669/mini_magick20211229-31892-ehyqpl.png?1640830456" /><img alt="PDF Icon" class="ds-work-cover--file-icon" src="//a.academia-assets.com/images/single_work_splash/adobe_icon.svg" /><div class="ds-work-cover--hover-container"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span><p>Download Free PDF</p></div><div class="ds-work-cover--ribbon-container">Download Free PDF</div><div class="ds-work-cover--ribbon-triangle"></div></button></div></div></div><div class="ds-work-card--work-information"><h1 class="ds-work-card--work-title">Dinámica mitocondrial en las enfermedades neurodegenerativas</h1><div class="ds-work-card--work-authors ds-work-card--detail"><a class="ds-work-card--author js-wsj-grid-card-author ds2-5-body-md ds2-5-body-link" data-author-id="44799785" href="https://independent.academia.edu/MinaK%C3%B6nigsberg"><img alt="Profile image of Mina Königsberg" class="ds-work-card--author-avatar" src="//a.academia-assets.com/images/s65_no_pic.png" />Mina Königsberg</a></div><div class="ds-work-card--detail"><p class="ds-work-card--detail ds2-5-body-sm">Gaceta de M�xico</p><div class="ds-work-card--work-metadata"><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">visibility</span><p class="ds2-5-body-sm" id="work-metadata-view-count">…</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">description</span><p class="ds2-5-body-sm">8 pages</p></div><div class="ds-work-card--work-metadata__stat"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">link</span><p class="ds2-5-body-sm">1 file</p></div></div><script>(async () => { const workId = 66463843; const worksViewsPath = "/v0/works/views?subdomain_param=api&work_ids%5B%5D=66463843"; const getWorkViews = async (workId) => { const response = await fetch(worksViewsPath); if (!response.ok) { throw new Error('Failed to load work views'); } const data = await response.json(); return data.views[workId]; }; // Get the view count for the work - we send this immediately rather than waiting for // the DOM to load, so it can be available as soon as possible (but without holding up // the backend or other resource requests, because it's a bit expensive and not critical). const viewCount = await getWorkViews(workId); const updateViewCount = (viewCount) => { try { const viewCountNumber = parseInt(viewCount, 10); if (viewCountNumber === 0) { // Remove the whole views element if there are zero views. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); return; } const commaizedViewCount = viewCountNumber.toLocaleString(); const viewCountBody = document.getElementById('work-metadata-view-count'); if (!viewCountBody) { throw new Error('Failed to find work views element'); } viewCountBody.textContent = `${commaizedViewCount} views`; } catch (error) { // Remove the whole views element if there was some issue parsing. document.getElementById('work-metadata-view-count')?.parentNode?.remove(); throw new Error(`Failed to parse view count: ${viewCount}`, error); } }; // If the DOM is still loading, wait for it to be ready before updating the view count. if (document.readyState === "loading") { document.addEventListener('DOMContentLoaded', () => { updateViewCount(viewCount); }); // Otherwise, just update it immediately. } else { updateViewCount(viewCount); } })();</script></div><p class="ds-work-card--work-abstract ds-work-card--detail ds2-5-body-md">Las enfermedades neurodegenerativas son un grupo heterogéneo caracterizado por la disminución gradual, progresiva y selectiva de las funciones del sistema nervioso. La etiología de estas patologías aún se desconoce, sin embargo, se ha propuesto que la función mitocondrial pudiese estar participando en el establecimiento de estas enfermedades, debido al alto requerimiento energético que tienen las neuronas para realizar sus funciones fisiológicas. La mitocondria es un organelo dinámico que puede cambiar su morfología y función en respuesta a diferentes estímulos fisiológicos, por ello se ha empezado a estudiar a la dinámica mitocondrial como uno de los principales reguladores de la supervivencia celular. Este evento comprende diferentes procesos como la generación de nuevas mitocondrias y su eliminación cuando ya no son funcionales, así como los procesos de fusión y fisión mitocondrial y el tráfico de estos organelos en el entorno celular. Todos estos procesos son altamente regulados y tienen como finalidad la óptima funcionalidad de la mitocondria y la homeostasis celular.</p><div class="ds-work-card--button-container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--work-card","attachmentId":77644669,"attachmentType":"pdf","workUrl":"https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas"}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--work-card","attachmentId":77644669,"attachmentType":"pdf","workUrl":"https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas"}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div><div class="ds-signup-banner-trigger-container"><div class="ds-signup-banner-trigger"></div></div><div class="ds-signup-banner"><div id="ds-signup-banner-close-button"><button class="ds2-5-button ds2-5-button--secondary ds2-5-button--inverse"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">close</span></button></div><div class="ds-signup-banner-ctas"><img src="//a.academia-assets.com/images/academia-logo-capital-white.svg" /><h4 class="ds2-5-heading-serif-sm">Sign up for access to the world's latest research.</h4><button class="ds2-5-button ds2-5-button--inverse ds2-5-button--full-width js-swp-download-button" data-signup-modal="{"location":"signup-banner"}">Sign up for free</button></div><div class="ds-signup-banner-divider"></div><div class="ds-signup-banner-reasons"><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Get notified about relevant papers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Save papers to use in your research</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Join the discussion with peers</span></div><div class="ds-signup-banner-reasons-item"><span class="material-symbols-outlined" style="font-size: 24px" translate="no">check</span><span>Track your impact</span></div></div></div><script>(() => { // Set up signup banner show/hide behavior: // 1. If the signup banner trigger (a 242px-high* invisible div underneath the 'See Full PDF' / 'Download PDF' buttons) // is already fully scrolled above the viewport, show the banner by default // 2. If the signup banner trigger is fully visible, show the banner // 3. If the signup banner trigger has even a few pixels scrolled below the viewport, hide the banner // // * 242px is the empirically determined height of the signup banner. It's better to be a bit taller than // necessary than too short, so it's fine that the mobile (small breakpoint) banner is shorter. // First check session storage for the signup banner's visibility state const signupBannerHidden = sessionStorage.getItem('ds-signup-banner-hidden'); if (signupBannerHidden === 'true') { return; } const signupBanner = document.querySelector('.ds-signup-banner'); const signupBannerTrigger = document.querySelector('.ds-signup-banner-trigger'); if (!signupBannerTrigger) { window.Sentry.captureMessage("Signup banner trigger not found"); return; } let footerShown = false; window.addEventListener('load', () => { const rect = signupBannerTrigger.getBoundingClientRect(); // If page loaded up already scrolled below the trigger (via scroll restoration), show the banner by default if (rect.bottom < 0) { footerShown = true; signupBanner.classList.add('ds-signup-banner-visible'); } }); // Wait for trigger to fully enter viewport before showing banner (ensures PDF CTAs are never covered by banner) const observer = new IntersectionObserver((entries) => { entries.forEach(entry => { if (entry.isIntersecting && !footerShown) { footerShown = true; signupBanner.classList.add('ds-signup-banner-visible'); } else if (!entry.isIntersecting && footerShown) { if (signupBannerTrigger.getBoundingClientRect().bottom > 0) { footerShown = false; signupBanner.classList.remove('ds-signup-banner-visible'); } } }); }); observer.observe(signupBannerTrigger); // Set up signup banner close button event handler: const signupBannerCloseButton = document.querySelector('#ds-signup-banner-close-button'); signupBannerCloseButton.addEventListener('click', () => { signupBanner.classList.remove('ds-signup-banner-visible'); observer.unobserve(signupBannerTrigger); // Store the signup banner's visibility state in session storage sessionStorage.setItem('ds-signup-banner-hidden', 'true'); }); })();</script></div></div></div><div data-auto_select="false" data-client_id="331998490334-rsn3chp12mbkiqhl6e7lu2q0mlbu0f1b" data-doc_id="77644669" data-landing_url="https://www.academia.edu/66463843/Din%C3%A1mica_mitocondrial_en_las_enfermedades_neurodegenerativas" data-login_uri="https://www.academia.edu/registrations/google_one_tap" data-moment_callback="onGoogleOneTapEvent" id="g_id_onload"></div><div class="ds-top-related-works--grid-container"><div class="ds-related-content--container ds-top-related-works--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="0" data-entity-id="88340725" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/88340725/Papel_de_la_funci%C3%B3n_mitocondrial_en_las_enfermedades_neurodegenerativas">Papel de la función mitocondrial en las enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="50517615" href="https://independent.academia.edu/TeresaCorona1">Teresa Corona</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Arch Neurocien ( …, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">Mitochondria main function is cellular respiration. In recent years the study of the role of the mitochondria in ageing and disease pathophysiology has increased providing new knowledge in animal models as well as in human beings. Objective: in this review we present a brief descritption of the mitocondria, its DNA and its role in ageing and in particular in neurodegenrative diseases. Method: along the review we cover the mitochondrial function and dysfunction in neurodegenerative diseases such as Huntington, Parkinson, Alzheimer and amyotrophic lateral sclerosis emphasizing on recent advances. Conclusion: the mitochondria plays a relevant role in the pathogenesis of various neurodegenerative diseases, the understanding of the cellular mechanisms involved would allow the development of new therapeutic interventions.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Papel de la función mitocondrial en las enfermedades neurodegenerativas","attachmentId":92332032,"attachmentType":"pdf","work_url":"https://www.academia.edu/88340725/Papel_de_la_funci%C3%B3n_mitocondrial_en_las_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/88340725/Papel_de_la_funci%C3%B3n_mitocondrial_en_las_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="1" data-entity-id="7114969" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/7114969/Din%C3%A1mica_mitocondrial_un_potencial_nuevo_blanco_terap%C3%A9utico_para_la_insuficiencia_cardiaca">Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="12245069" href="https://uv-cl.academia.edu/CamilaValentina">Camila Valentina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Espanola De Cardiologia, 2011</p><p class="ds-related-work--abstract ds2-5-body-sm">La insuficiencia cardiaca es una afecció n compleja caracterizada por la incapacidad del corazó n para responder con un gasto cardiaco acorde a la demanda metabó lica del resto de los tejidos. Esta enfermedad representa el estado terminal de las cardiopatías isqué mica, valvular o hipertensiva 1 . En los países industrializados, donde la esperanza de vida de la població n y la sobrevida a otras enfermedades cardiacas es elevada, la insuficiencia cardiaca es una enfermedad de alta prevalencia 2,3 . La comprensió n de la fisiopatología de la insuficiencia cardiaca ha permitido el establecimiento de la terapia está ndar basada en el uso de bloqueadores beta combinado con el bloqueo del sistema renina-angiotensina-aldosterona a travé s de inhibidores de la enzima de conversió n de la angiotensina, antagonistas del receptor de la angiotensina II, antagonistas del receptor de aldosterona y, en algunos casos, la terapia de resincronizació n 4 . A pesar de estos avances, la mortalidad anual asociada a insuficiencia cardiaca se mantiene cercana al 10%, y se desconoce la razó n por la cual esta enfermedad progresa incluso con una terapia ó ptima 5 . Estos antecedentes ponen en evidencia la necesidad de desarrollar nuevos blancos terapé uticos dirigidos a otros mecanismos moleculares y celulares alterados en esta enfermedad.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dinámica mitocondrial: un potencial nuevo blanco terapéutico para la insuficiencia cardiaca","attachmentId":48595627,"attachmentType":"pdf","work_url":"https://www.academia.edu/7114969/Din%C3%A1mica_mitocondrial_un_potencial_nuevo_blanco_terap%C3%A9utico_para_la_insuficiencia_cardiaca","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/7114969/Din%C3%A1mica_mitocondrial_un_potencial_nuevo_blanco_terap%C3%A9utico_para_la_insuficiencia_cardiaca"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="2" data-entity-id="50543550" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/50543550/Rol_del_eje_tirotr%C3%B3pico_en_enfermedades_neurodegenerativas">Rol del eje tirotrópico en enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="42135990" href="https://independent.academia.edu/LuisAlmaguerMederos">Luis Almaguer-Mederos</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Las hormonas tiroideas actúan como reguladores primarios del metabolismo intermediario en todos los tejidos del organismo; tienen funciones de gran trascendencia a nivel del sistema nervioso, donde ejercen acciones potencialmente neuroprotectoras. Los niveles de las hormonas tiroideas están sujetos a una estrecha regulación en el sistema nervioso y se sugiere que incluso ligeras desviaciones del rango de normalidad pueden estar asociadas a enfermedades neurodegenerativas. En esta revisión se resumieron los hallazgos existentes en torno al papel de las hormonas tiroideas en la fisiología normal y patológica del sistema nervioso, con énfasis en enfermedades neurodegenerativas y los mecanismos moleculares implicados. Las evidencias indican un rol significativo para las hormonas tiroideas en varias enfermedades neurodegenerativas, si bien es necesaria la realización de estudios prospectivos de mayor envergadura para precisar su función y evaluar su utilidad como bio-marcadores y dianas ...</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Rol del eje tirotrópico en enfermedades neurodegenerativas","attachmentId":68484987,"attachmentType":"pdf","work_url":"https://www.academia.edu/50543550/Rol_del_eje_tirotr%C3%B3pico_en_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/50543550/Rol_del_eje_tirotr%C3%B3pico_en_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="3" data-entity-id="33327157" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33327157/Las_mitocondrias_como_blanco_terap%C3%A9utico">Las mitocondrias como blanco terapéutico</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65137346" href="https://independent.academia.edu/LatourManuel">Manuel Latour</a></div><p class="ds-related-work--abstract ds2-5-body-sm">Este artículo puede ser consultado en versión completa en RESUMEN Las mitocondrias tienen un importante papel en la producción de energía en las células. Además de sus bien conocidos papeles en la fosforilación oxidativa y en el metabolismo, ahora es claro que las mitocondrias son centrales en la muerte celular, neoplasias, en la diferenciación celular, en el sistema inmune innato, en la detección de los niveles de oxígeno y de la hipoxia y en el meta-bolismo del calcio. Estos organelos están siendo progresivamente reconocidos como elementos clave en muchas áreas de la ciencia biomédica. La alteración de cualquiera de los papeles funcionales de las mitocondrias contribuye a diversas patologías, por lo que hace de este organelo un blanco terapéutico potencialmente importante, aunque no considerado así hasta recientemente. La disfunción mitocondrial está a menudo asociada con el daño oxidativo, la alteración en la homeostasis de calcio, defectos en la síntesis de ATP o con la inducción del poro de la transición de la permeabilidad. Consecuentemente, las terapias diseñadas para prevenir este tipo de daños son benéfi cas en diversos padecimientos que incluso podrían parecer no relacionados. En esta revisión resaltamos las propiedades biológicas que hacen a la mitocondria elemento determinante de la salud y de la enfermedad. Además se describen las po-sibles estrategias farmacológicas que están siendo desarrolladas e incluso, algunas que ya se aplican en los seres humanos para corregir la disfunción mitocondrial. La mitocondria considerada como un blanco terapéutico junto con los compuestos que ya se usan para corregir su disfunción daría lugar a lo que llamaríamos farmacología mitocondrial, la cual es una disciplina muy prometedora con un enorme potencial para nuevos abordajes terapéuticos con implicaciones en múltiples patologías. SUMMARY Mitochondria have an important role in energy production in cells. In addition to their well known roles in oxidative phosphorylation and metabolism, it is now clear that the mitochondria are also central to cell death, neoplasia, cell differentiation, and the innate immune system, for detecting levels of oxygen and hypoxia and calcium homeostasis. These organelles are increasingly being recognized as key elements in many areas of biomedical science. The disruption of any of the functional roles of mitochondria contributes to diseases, so this organelle turns on a potentially important therapeutic target apparently not considered until recently. Mitochondrial dysfunction is often associated with oxidative damage, alterations in calcium homeostasis and defects in the synthesis of ATP or induction of the permeability transition pore. Thus, therapies designed to prevent this type of damage are benefi cial in various conditions that may even seem unrelated. In this review we highlight the biological properties that make mitochondria determinants of health and disease. Besides the possible pharmacological strategies www.medigraphic.org.mx</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Las mitocondrias como blanco terapéutico","attachmentId":53388390,"attachmentType":"pdf","work_url":"https://www.academia.edu/33327157/Las_mitocondrias_como_blanco_terap%C3%A9utico","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33327157/Las_mitocondrias_como_blanco_terap%C3%A9utico"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="4" data-entity-id="23151840" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/23151840/Dianas_farmacol%C3%B3gicas_en_las_enfermedades_neurodegenerativas">Dianas farmacológicas en las enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="44929893" href="https://independent.academia.edu/Tom%C3%A1sSegura">Tomás Segura</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Dianas farmacológicas en las enfermedades neurodegenerativas","attachmentId":43638088,"attachmentType":"pdf","work_url":"https://www.academia.edu/23151840/Dianas_farmacol%C3%B3gicas_en_las_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/23151840/Dianas_farmacol%C3%B3gicas_en_las_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="5" data-entity-id="65478250" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/65478250/Neuropatolog%C3%ADa_De_Las_Demencias_Neurodegenerativas">Neuropatología De Las Demencias Neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="94856961" href="https://independent.academia.edu/ArriagadaPaulina">Paulina Arriagada</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Médica Clínica Las Condes, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neuropatología De Las Demencias Neurodegenerativas","attachmentId":77056864,"attachmentType":"pdf","work_url":"https://www.academia.edu/65478250/Neuropatolog%C3%ADa_De_Las_Demencias_Neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/65478250/Neuropatolog%C3%ADa_De_Las_Demencias_Neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="6" data-entity-id="15317352" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/15317352/Glicaci%C3%B3n_de_prote%C3%ADnas_mitocondriales_estr%C3%A9s_oxidativo_y_envejecimiento">Glicación de proteínas mitocondriales, estrés oxidativo y envejecimiento</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34424312" href="https://udl.academia.edu/ReinaldPamplona">Reinald Pamplona</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Española de Geriatría y Gerontología, 2010</p><p class="ds-related-work--abstract ds2-5-body-sm">El anciano en situación crítica: nuevos retos en la asistencia geriátrica del futuro A. López-Soto y E. Sacanella</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Glicación de proteínas mitocondriales, estrés oxidativo y envejecimiento","attachmentId":43338953,"attachmentType":"pdf","work_url":"https://www.academia.edu/15317352/Glicaci%C3%B3n_de_prote%C3%ADnas_mitocondriales_estr%C3%A9s_oxidativo_y_envejecimiento","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/15317352/Glicaci%C3%B3n_de_prote%C3%ADnas_mitocondriales_estr%C3%A9s_oxidativo_y_envejecimiento"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="7" data-entity-id="33327154" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33327154/Neurolog%C3%ADa_Argentina_Revisi%C3%B3n_Tres_preguntas_y_una_respuesta_algoritmo_diagn%C3%B3stico_molecular_en_enfermedades_mitocondriales">Neurología Argentina Revisión Tres preguntas y una respuesta: algoritmo diagnóstico molecular en enfermedades mitocondriales</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65137346" href="https://independent.academia.edu/LatourManuel">Manuel Latour</a></div><p class="ds-related-work--abstract ds2-5-body-sm">información del artículo Historia del artículo: Recibido el 5 de septiembre de 2012 Aceptado el 6 de octubre de 2012 On-line el 30 de noviembre de 2012 Palabras clave: Trastornos mitocondriales Genética mitocondrial Defectos de la fosforilación oxidativa r e s u m e n Introducción: Las enfermedades mitocondriales representan un grupo de trastornos multisistémicos, que frecuentemente incluyen disfunción del sistema nervioso central y periférico entre sus manifestaciones, causados por diversas mutaciones localizadas tanto en el genoma mitocondrial como en el nuclear. La amplia variabilidad observada en su expresión clínica y la amplitud etiopatogénica complica su diagnóstico molecular.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neurología Argentina Revisión Tres preguntas y una respuesta: algoritmo diagnóstico molecular en enfermedades mitocondriales","attachmentId":53388389,"attachmentType":"pdf","work_url":"https://www.academia.edu/33327154/Neurolog%C3%ADa_Argentina_Revisi%C3%B3n_Tres_preguntas_y_una_respuesta_algoritmo_diagn%C3%B3stico_molecular_en_enfermedades_mitocondriales","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33327154/Neurolog%C3%ADa_Argentina_Revisi%C3%B3n_Tres_preguntas_y_una_respuesta_algoritmo_diagn%C3%B3stico_molecular_en_enfermedades_mitocondriales"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="8" data-entity-id="33590505" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33590505/Mecanismos_de_da%C3%B1o_celular_en_enfermedades_neurodegenerativas">Mecanismos de daño celular en enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="53791949" href="https://independent.academia.edu/MGonzalezHita">M. González-Hita</a><span>, </span><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="56828526" href="https://independent.academia.edu/SSanchezEnriquez">Sergio Sanchez Enriquez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Investigacion En Salud, 2007</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mecanismos de daño celular en enfermedades neurodegenerativas","attachmentId":53611668,"attachmentType":"pdf","work_url":"https://www.academia.edu/33590505/Mecanismos_de_da%C3%B1o_celular_en_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/33590505/Mecanismos_de_da%C3%B1o_celular_en_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-wsj-grid-card" data-collection-position="9" data-entity-id="54181375" data-sort-order="default"><a class="ds-related-work--title js-wsj-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54181375/Enfermedades_gen_ticas_del_ADN_mitocondrial_humano">Enfermedades gen�ticas del ADN mitocondrial humano</a><div class="ds-related-work--metadata"><a class="js-wsj-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34405003" href="https://independent.academia.edu/JulioMontoya7">Julio Montoya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Salud Publica Mexico, 2001</p><p class="ds-related-work--abstract ds2-5-body-sm">Mitochondrial diseases are a group of disorders produced by defects in the oxidative phosphorylation system (Oxphos system), the final pathway of the mitochondrial energetic metabolism, resulting in a deficiency of the biosynthesis of ATP. Part of the polypeptide subunits involved in the Oxphos system are codified by the mitochondrial DNA. In the last years, mutations in this genetic system have been described and associated to well defined clinical syndromes. The clinical features of these disorders are very heterogeneous affecting, in most cases, to different organs and tissues and their correct diagnosis require precise clinical, morphological, biochemical and genetic data. The peculiar genetic characteristics of the mitochondrial DNA (maternal inheritance, polyplasmia and mitotic segregation) give to these disorders very distinctive properties.</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Enfermedades gen�ticas del ADN mitocondrial humano","attachmentId":70669465,"attachmentType":"pdf","work_url":"https://www.academia.edu/54181375/Enfermedades_gen_ticas_del_ADN_mitocondrial_humano","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-wsj-grid-card-view-pdf" href="https://www.academia.edu/54181375/Enfermedades_gen_ticas_del_ADN_mitocondrial_humano"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div></div><div class="ds-sticky-ctas--wrapper js-loswp-sticky-ctas hidden"><div class="ds-sticky-ctas--grid-container"><div class="ds-sticky-ctas--container"><button class="ds2-5-button js-swp-download-button" data-signup-modal="{"location":"continue-reading-button--sticky-ctas","attachmentId":77644669,"attachmentType":"pdf","workUrl":null}">See full PDF</button><button class="ds2-5-button ds2-5-button--secondary js-swp-download-button" data-signup-modal="{"location":"download-pdf-button--sticky-ctas","attachmentId":77644669,"attachmentType":"pdf","workUrl":null}"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">download</span>Download PDF</button></div></div></div><div class="ds-below-fold--grid-container"><div class="ds-work--container js-loswp-embedded-document"><div class="attachment_preview" data-attachment="Attachment_77644669" style="display: none"><div class="js-scribd-document-container"><div class="scribd--document-loading js-scribd-document-loader" style="display: block;"><img alt="Loading..." src="//a.academia-assets.com/images/loaders/paper-load.gif" /><p>Loading Preview</p></div></div><div style="text-align: center;"><div class="scribd--no-preview-alert js-preview-unavailable"><p>Sorry, preview is currently unavailable. You can download the paper by clicking the button above.</p></div></div></div></div><div class="ds-sidebar--container js-work-sidebar"><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related papers</h2><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="0" data-entity-id="84837183" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/84837183/Papel_del_p%C3%A9ptido_mitocondrial_humanina_como_blanco_terap%C3%A9utico_en_c%C3%A1ncer_y_neurodegeneraci%C3%B3n">Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="222393103" href="https://independent.academia.edu/AlejandroNicolaCandia">Alejandro Nicola Candia</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nova, 2019</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración","attachmentId":89725724,"attachmentType":"pdf","work_url":"https://www.academia.edu/84837183/Papel_del_p%C3%A9ptido_mitocondrial_humanina_como_blanco_terap%C3%A9utico_en_c%C3%A1ncer_y_neurodegeneraci%C3%B3n","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/84837183/Papel_del_p%C3%A9ptido_mitocondrial_humanina_como_blanco_terap%C3%A9utico_en_c%C3%A1ncer_y_neurodegeneraci%C3%B3n"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="1" data-entity-id="114871150" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/114871150/Neuroim%C3%A1genes_en_Demencias">Neuroimágenes en Demencias</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="3207509" href="https://uchilefau.academia.edu/EnzoBrunetti">Enzo Brunetti</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista Médica Clínica Las Condes, 2016</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Neuroimágenes en Demencias","attachmentId":111445013,"attachmentType":"pdf","work_url":"https://www.academia.edu/114871150/Neuroim%C3%A1genes_en_Demencias","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/114871150/Neuroim%C3%A1genes_en_Demencias"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="2" data-entity-id="32614952" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/32614952/Implicaciones_neuropsiqui%C3%A1tricas_de_las_citopat%C3%ADas_mitocondriales_A_prop%C3%B3sito_de_un_caso">Implicaciones neuropsiquiátricas de las citopatías mitocondriales. A propósito de un caso</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="63255355" href="https://independent.academia.edu/AngelRoyuela">Angel Royuela</a><span>, </span><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="37928861" href="https://independent.academia.edu/MariaJesus34">Maria Jesus</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Psiquiatría Biológica, 2012</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Implicaciones neuropsiquiátricas de las citopatías mitocondriales. A propósito de un caso","attachmentId":52787784,"attachmentType":"pdf","work_url":"https://www.academia.edu/32614952/Implicaciones_neuropsiqui%C3%A1tricas_de_las_citopat%C3%ADas_mitocondriales_A_prop%C3%B3sito_de_un_caso","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/32614952/Implicaciones_neuropsiqui%C3%A1tricas_de_las_citopat%C3%ADas_mitocondriales_A_prop%C3%B3sito_de_un_caso"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="3" data-entity-id="8159793" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8159793/C%C3%A9lulas_madre_en_la_modelaci%C3%B3n_de_enfermedades_neurodegenerativas">Células madre en la modelación de enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15927989" href="https://independent.academia.edu/LuisBedian">Luis Bedian</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Células madre en la modelación de enfermedades neurodegenerativas","attachmentId":34597118,"attachmentType":"docx","work_url":"https://www.academia.edu/8159793/C%C3%A9lulas_madre_en_la_modelaci%C3%B3n_de_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/8159793/C%C3%A9lulas_madre_en_la_modelaci%C3%B3n_de_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="4" data-entity-id="8093750" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/8093750/Redalyc_ADN_mitocondrial_envejecimiento_y_cancer">Redalyc.ADN mitocondrial envejecimiento y cancer</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="15670415" href="https://ujat.academia.edu/KrisJes%C3%BAs">Kris Jesús</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Redalyc.ADN mitocondrial envejecimiento y cancer","attachmentId":34543535,"attachmentType":"pdf","work_url":"https://www.academia.edu/8093750/Redalyc_ADN_mitocondrial_envejecimiento_y_cancer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/8093750/Redalyc_ADN_mitocondrial_envejecimiento_y_cancer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="5" data-entity-id="44149961" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/44149961/INTRODUCCI%C3%93N_Y_ASPECTOS_GENERALES_Enfermedades_mitocondriales">INTRODUCCIÓN Y ASPECTOS GENERALES Enfermedades mitocondriales</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="171521171" href="https://bash.academia.edu/FernandoVillalpando">Fernando Villalpando</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"INTRODUCCIÓN Y ASPECTOS GENERALES Enfermedades mitocondriales","attachmentId":64505024,"attachmentType":"pdf","work_url":"https://www.academia.edu/44149961/INTRODUCCI%C3%93N_Y_ASPECTOS_GENERALES_Enfermedades_mitocondriales","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/44149961/INTRODUCCI%C3%93N_Y_ASPECTOS_GENERALES_Enfermedades_mitocondriales"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="6" data-entity-id="19892857" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/19892857/Debut_de_enfermedad_mitocondrial_en_edad_adulta">Debut de enfermedad mitocondrial en edad adulta</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="40727210" href="https://independent.academia.edu/Juli%C3%A1nCarreterog%C3%B3mez">Julián Carretero-gómez</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Debut de enfermedad mitocondrial en edad adulta","attachmentId":41195597,"attachmentType":"pdf","work_url":"https://www.academia.edu/19892857/Debut_de_enfermedad_mitocondrial_en_edad_adulta","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/19892857/Debut_de_enfermedad_mitocondrial_en_edad_adulta"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="7" data-entity-id="79301901" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/79301901/Trastornos_neuroconductuales_en_la_demencia_tipo_Alzheimer">Trastornos neuroconductuales en la demencia tipo Alzheimer</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="71978290" href="https://independent.academia.edu/ManuelLucendo">Manuel Lucendo</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Terapia psicológica, 2020</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Trastornos neuroconductuales en la demencia tipo Alzheimer","attachmentId":86062833,"attachmentType":"pdf","work_url":"https://www.academia.edu/79301901/Trastornos_neuroconductuales_en_la_demencia_tipo_Alzheimer","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/79301901/Trastornos_neuroconductuales_en_la_demencia_tipo_Alzheimer"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="8" data-entity-id="33327155" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/33327155/Cu%C3%A1ndo_hay_que_pensar_en_una_enfermedad_mitocondrial">Cuándo hay que pensar en una enfermedad mitocondrial</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="65137346" href="https://independent.academia.edu/LatourManuel">Manuel Latour</a></div><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Cuándo hay que pensar en una enfermedad mitocondrial","attachmentId":53388386,"attachmentType":"pdf","work_url":"https://www.academia.edu/33327155/Cu%C3%A1ndo_hay_que_pensar_en_una_enfermedad_mitocondrial","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/33327155/Cu%C3%A1ndo_hay_que_pensar_en_una_enfermedad_mitocondrial"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="9" data-entity-id="54181266" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/54181266/Enfermedades_gen%C3%A9ticas_del_ADN_mitocondrial_humano">Enfermedades genéticas del ADN mitocondrial humano</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="34405003" href="https://independent.academia.edu/JulioMontoya7">Julio Montoya</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Salud Pública de México, 2001</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Enfermedades genéticas del ADN mitocondrial humano","attachmentId":70669409,"attachmentType":"pdf","work_url":"https://www.academia.edu/54181266/Enfermedades_gen%C3%A9ticas_del_ADN_mitocondrial_humano","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/54181266/Enfermedades_gen%C3%A9ticas_del_ADN_mitocondrial_humano"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="10" data-entity-id="75074052" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/75074052/Mitocondria_y_muerte_celular">Mitocondria y muerte celular</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="174796536" href="https://independent.academia.edu/RuthSanchez108">Ruth Sanchez</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Nova, 2008</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Mitocondria y muerte celular","attachmentId":82990583,"attachmentType":"pdf","work_url":"https://www.academia.edu/75074052/Mitocondria_y_muerte_celular","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/75074052/Mitocondria_y_muerte_celular"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="11" data-entity-id="114849854" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/114849854/Terapia_con_c%C3%A9lulas_madre_en_enfermedades_neurodegenerativas">Terapia con células madre en enfermedades neurodegenerativas</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="39237949" href="https://independent.academia.edu/JoseMoraleda">Jose Moraleda</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Revista de …, 2011</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Terapia con células madre en enfermedades neurodegenerativas","attachmentId":111430275,"attachmentType":"pdf","work_url":"https://www.academia.edu/114849854/Terapia_con_c%C3%A9lulas_madre_en_enfermedades_neurodegenerativas","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/114849854/Terapia_con_c%C3%A9lulas_madre_en_enfermedades_neurodegenerativas"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div><div class="ds-related-work--container js-related-work-sidebar-card" data-collection-position="12" data-entity-id="90407294" data-sort-order="default"><a class="ds-related-work--title js-related-work-grid-card-title ds2-5-body-md ds2-5-body-link" href="https://www.academia.edu/90407294/Diagn%C3%B3stico_de_las_enfermedades_mitocondriales_utilidad_de_un_abordaje_cl%C3%ADnico_molecular_sistematizado_incorporando_secuenciaci%C3%B3n_de_alto_rendimiento">Diagnóstico de las enfermedades mitocondriales: utilidad de un abordaje clínico-molecular sistematizado incorporando secuenciación de alto rendimiento</a><div class="ds-related-work--metadata"><a class="js-related-work-grid-card-author ds2-5-body-sm ds2-5-body-link" data-author-id="244595457" href="https://independent.academia.edu/NancyL%C3%B3pezMedina">Nancy López Medina</a></div><p class="ds-related-work--metadata ds2-5-body-xs">Neurología Argentina, 2017</p><div class="ds-related-work--ctas"><button class="ds2-5-text-link ds2-5-text-link--inline js-swp-download-button" data-signup-modal="{"location":"wsj-grid-card-download-pdf-modal","work_title":"Diagnóstico de las enfermedades mitocondriales: utilidad de un abordaje clínico-molecular sistematizado incorporando secuenciación de alto rendimiento","attachmentId":93979096,"attachmentType":"pdf","work_url":"https://www.academia.edu/90407294/Diagn%C3%B3stico_de_las_enfermedades_mitocondriales_utilidad_de_un_abordaje_cl%C3%ADnico_molecular_sistematizado_incorporando_secuenciaci%C3%B3n_de_alto_rendimiento","alternativeTracking":true}"><span class="material-symbols-outlined" style="font-size: 18px" translate="no">download</span><span class="ds2-5-text-link__content">Download free PDF</span></button><a class="ds2-5-text-link ds2-5-text-link--inline js-related-work-grid-card-view-pdf" href="https://www.academia.edu/90407294/Diagn%C3%B3stico_de_las_enfermedades_mitocondriales_utilidad_de_un_abordaje_cl%C3%ADnico_molecular_sistematizado_incorporando_secuenciaci%C3%B3n_de_alto_rendimiento"><span class="ds2-5-text-link__content">View PDF</span><span class="material-symbols-outlined" style="font-size: 18px" translate="no">chevron_right</span></a></div></div></div><div class="ds-related-content--container"><h2 class="ds-related-content--heading">Related topics</h2><div class="ds-research-interests--pills-container"><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="7710" href="https://www.academia.edu/Documents/in/Biology">Biology</a><a class="js-related-research-interest ds-research-interests--pill" data-entity-id="26327" href="https://www.academia.edu/Documents/in/Medicine">Medicine</a></div></div></div></div></div><div class="footer--content"><ul class="footer--main-links hide-on-mobile"><li><a href="https://www.academia.edu/about">About</a></li><li><a href="https://www.academia.edu/press">Press</a></li><li><a href="https://www.academia.edu/documents">Papers</a></li><li><a href="https://www.academia.edu/topics">Topics</a></li><li><a href="https://www.academia.edu/hiring"><svg style="width: 13px; height: 13px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="briefcase" class="svg-inline--fa fa-briefcase fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M320 336c0 8.84-7.16 16-16 16h-96c-8.84 0-16-7.16-16-16v-48H0v144c0 25.6 22.4 48 48 48h416c25.6 0 48-22.4 48-48V288H320v48zm144-208h-80V80c0-25.6-22.4-48-48-48H176c-25.6 0-48 22.4-48 48v48H48c-25.6 0-48 22.4-48 48v80h512v-80c0-25.6-22.4-48-48-48zm-144 0H192V96h128v32z"></path></svg> <strong>We're Hiring!</strong></a></li><li><a href="https://support.academia.edu/"><svg style="width: 12px; height: 12px; position: relative; bottom: -1px;" aria-hidden="true" focusable="false" data-prefix="fas" data-icon="question-circle" class="svg-inline--fa fa-question-circle fa-w-16" role="img" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 512 512"><path fill="currentColor" d="M504 256c0 136.997-111.043 248-248 248S8 392.997 8 256C8 119.083 119.043 8 256 8s248 111.083 248 248zM262.655 90c-54.497 0-89.255 22.957-116.549 63.758-3.536 5.286-2.353 12.415 2.715 16.258l34.699 26.31c5.205 3.947 12.621 3.008 16.665-2.122 17.864-22.658 30.113-35.797 57.303-35.797 20.429 0 45.698 13.148 45.698 32.958 0 14.976-12.363 22.667-32.534 33.976C247.128 238.528 216 254.941 216 296v4c0 6.627 5.373 12 12 12h56c6.627 0 12-5.373 12-12v-1.333c0-28.462 83.186-29.647 83.186-106.667 0-58.002-60.165-102-116.531-102zM256 338c-25.365 0-46 20.635-46 46 0 25.364 20.635 46 46 46s46-20.636 46-46c0-25.365-20.635-46-46-46z"></path></svg> <strong>Help Center</strong></a></li></ul><ul class="footer--research-interests"><li>Find new research papers in:</li><li><a href="https://www.academia.edu/Documents/in/Physics">Physics</a></li><li><a href="https://www.academia.edu/Documents/in/Chemistry">Chemistry</a></li><li><a href="https://www.academia.edu/Documents/in/Biology">Biology</a></li><li><a href="https://www.academia.edu/Documents/in/Health_Sciences">Health Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Ecology">Ecology</a></li><li><a href="https://www.academia.edu/Documents/in/Earth_Sciences">Earth Sciences</a></li><li><a href="https://www.academia.edu/Documents/in/Cognitive_Science">Cognitive Science</a></li><li><a href="https://www.academia.edu/Documents/in/Mathematics">Mathematics</a></li><li><a href="https://www.academia.edu/Documents/in/Computer_Science">Computer Science</a></li></ul><ul class="footer--legal-links hide-on-mobile"><li><a href="https://www.academia.edu/terms">Terms</a></li><li><a href="https://www.academia.edu/privacy">Privacy</a></li><li><a href="https://www.academia.edu/copyright">Copyright</a></li><li>Academia ©2025</li></ul></div> </body> </html>