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Pisareva</h3></div><div class="js-work-strip profile--work_container" data-work-id="96417429"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/96417429/Early_Pulmonary_Lesions_in_Influenza"><img alt="Research paper thumbnail of Early Pulmonary Lesions in Influenza" class="work-thumbnail" src="https://attachments.academia-assets.com/98321168/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/96417429/Early_Pulmonary_Lesions_in_Influenza">Early Pulmonary Lesions in Influenza</a></div><div class="wp-workCard_item"><span>CHILDREN INFECTIONS</span><span>, 2017</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="76addc5c1f5b144562e84cad16850769" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98321168,"asset_id":96417429,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98321168/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96417429"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96417429"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96417429; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96417429]").text(description); $(".js-view-count[data-work-id=96417429]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96417429; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96417429']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96417429, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "76addc5c1f5b144562e84cad16850769" } } $('.js-work-strip[data-work-id=96417429]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96417429,"title":"Early Pulmonary Lesions in Influenza","translated_title":"","metadata":{"publisher":"Journal of Childrens Infections","grobid_abstract":"Сравнительный анализ результатов клинико-лабораторного обследования 379 пациентов, госпитализированных в течение 2009-2016 гг. по поводу гриппа, осложненного пневмонией, показал, что наиболее тяжелые формы поражений легких статистически значимо чаще развиваются в первые три дня заболевания гриппом, обусловленного шифтово измененным возбудителем, у пациентов с наличием коморбидной патологии-хроническими заболеваниями сердца и сосудов (изолированно или в ассоциации с другими факторами). 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At the same time in 2009-2011 was marked significant prevalence of pandemic influenza virus infection A(Н1N1)v in a kind mono- and mikst-infections (in 18,8 and 10,2 % of cases accordingly), and adenoviruses, espiratory sincitial viruses and parainfluenza were the most frequent concomitants (in 4,8, 3,2 and 2,4 % of cases). In a clinical picture of disease acute nasopharynx lesion (67,8 %) was predominated, complicating by croup in 12,2 % of cases, by acute bronchitis in 12,1 % of cases, and more rare by pneumonia (in 8,2 % of cases). The analysis of results of immunofluorescence test in comparison with the cumulative data of other laboratory methods (polymerase chain reaction, immuneenzyme analysis, virus isolation, serological examination) has shown possibility of discovery with its help the valua...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a069e24efbb52101066d4a0ca7a6554" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98318879,"asset_id":96414087,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98318879/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96414087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96414087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96414087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96414087]").text(description); $(".js-view-count[data-work-id=96414087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96414087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96414087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96414087, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a069e24efbb52101066d4a0ca7a6554" } } $('.js-work-strip[data-work-id=96414087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96414087,"title":"ЛАБОРАТОРНАЯ ДИАГНОСТИКА ОСТРЫХ РЕСПИРАТОРНЫХ ВИРУСНЫХ ИНФЕКЦИЙ В УСЛОВИЯХ ЭВОЛЮЦИОННОЙ ИЗМЕНЧИВОСТИ ВИРУСОВ ГРИППА","translated_title":"","metadata":{"abstract":"As a result of laboratory investigation 1651 patients at the age from 0 months till 18 years, hospitalized with ARI from 2008 to 2011, in ¾ cases the virus etiology of disease was found. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88730930"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88730930/%D0%98%D1%81%D0%BF%D0%BE%D0%BB%D1%8C%D0%B7%D0%BE%D0%B2%D0%B0%D0%BD%D0%B8%D0%B5_%D0%BC%D0%B8%D0%BA%D1%80%D0%BE%D0%BA%D1%83%D0%BB%D1%8C%D1%82%D1%83%D1%80%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D1%84%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B0%D0%BD%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0_%D0%B4%D0%BB%D1%8F_%D1%81%D1%83%D0%B1%D1%82%D0%B8%D0%BF%D0%BE%D0%B2%D0%BE%D0%B9_%D0%B8%D0%B4%D0%B5%D0%BD%D1%82%D0%B8%D1%84%D0%B8%D0%BA%D0%B0%D1%86%D0%B8%D0%B8_%D1%86%D0%B8%D1%80%D0%BA%D1%83%D0%BB%D0%B8%D1%80%D1%83%D1%8E%D1%89%D0%B8%D1%85_%D0%B2%D0%B8%D1%80%D1%83%D1%81%D0%BE%D0%B2_%D0%B3%D1%80%D0%B8%D0%BF%D0%BF%D0%B0_%D0%90_%D0%9D1_%D0%B8_%D0%90_%D0%9D3_"><img alt="Research paper thumbnail of Использование микрокультурального иммуноферментного анализа для субтиповой идентификации циркулирующих вирусов гриппа А(Н1) и А(Н3)" class="work-thumbnail" src="https://attachments.academia-assets.com/92650846/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88730930/%D0%98%D1%81%D0%BF%D0%BE%D0%BB%D1%8C%D0%B7%D0%BE%D0%B2%D0%B0%D0%BD%D0%B8%D0%B5_%D0%BC%D0%B8%D0%BA%D1%80%D0%BE%D0%BA%D1%83%D0%BB%D1%8C%D1%82%D1%83%D1%80%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D1%84%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B0%D0%BD%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0_%D0%B4%D0%BB%D1%8F_%D1%81%D1%83%D0%B1%D1%82%D0%B8%D0%BF%D0%BE%D0%B2%D0%BE%D0%B9_%D0%B8%D0%B4%D0%B5%D0%BD%D1%82%D0%B8%D1%84%D0%B8%D0%BA%D0%B0%D1%86%D0%B8%D0%B8_%D1%86%D0%B8%D1%80%D0%BA%D1%83%D0%BB%D0%B8%D1%80%D1%83%D1%8E%D1%89%D0%B8%D1%85_%D0%B2%D0%B8%D1%80%D1%83%D1%81%D0%BE%D0%B2_%D0%B3%D1%80%D0%B8%D0%BF%D0%BF%D0%B0_%D0%90_%D0%9D1_%D0%B8_%D0%90_%D0%9D3_">Использование микрокультурального иммуноферментного анализа для субтиповой идентификации циркулирующих вирусов гриппа А(Н1) и А(Н3)</a></div><div class="wp-workCard_item"><span>Microbiology Independent Research journal</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c2c8abf1e6bdfff77ae43c9745c530fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":92650846,"asset_id":88730930,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/92650846/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88730930"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88730930"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88730930; 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Метод основан на оценке репродукции вируса в инфицированной культуре клеток MDCK c использованием на стадии детекции cубтип-специфичных моноклональных антител (mAb), взаимодействующих с гемагглютинином (HA) вируса гриппа. При отработке метода использованы штаммы вирусов гриппа A, выделенные из клинических образцов в эпидемический сезон 2014 года. Показано, что при использовании mAb #1/#2 или #4 в концентрации 10-15 мкг/мл разработанный вариант cell-ELISA позволяет детектировать синтезируемый в зараженных клетках белок HA соответственно вирусов гриппа А(H3N2) или A(H1N1)pdm09. 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The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="80bbaa002fd7a442145514e9fab3cefc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124557,"asset_id":79394776,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124557/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394776"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394776"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394776; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394776]").text(description); $(".js-view-count[data-work-id=79394776]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394776; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394776']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394776, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "80bbaa002fd7a442145514e9fab3cefc" } } $('.js-work-strip[data-work-id=79394776]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394776,"title":"Peculiarities of Etiology of Respiratory Virus Infections in Hospitalized Patients Depending on the Demographic, Socio-Economic Factors and Previous Vaccination","translated_title":"","metadata":{"abstract":"Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...","publisher":"LLC Numicom","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Epidemiology and Vaccine Prevention"},"translated_abstract":"Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...","internal_url":"https://www.academia.edu/79394776/Peculiarities_of_Etiology_of_Respiratory_Virus_Infections_in_Hospitalized_Patients_Depending_on_the_Demographic_Socio_Economic_Factors_and_Previous_Vaccination","translated_internal_url":"","created_at":"2022-05-18T10:30:18.261-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86124557,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86124557/thumbnails/1.jpg","file_name":"62.pdf","download_url":"https://www.academia.edu/attachments/86124557/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Peculiarities_of_Etiology_of_Respiratory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86124557/62-libre.pdf?1652895593=\u0026response-content-disposition=attachment%3B+filename%3DPeculiarities_of_Etiology_of_Respiratory.pdf\u0026Expires=1733019525\u0026Signature=Mfl1cNUEGFCxNQGzLwFhTYw~6NU5cpAshJ3PvXRY2RKRMAP4tw~z9x6eG6B1Q9x2Tb~KM3AcXvl~ChmBe0W8Psp2CQ959Ig5H0D5TOytnYIntVRY70HP4lzrLbbGcvOVg-cdyHxNwzqkF2fj~R~BBT2Mbk~xlUVKZQas1NoO8lnxJnJO1SKiikZx4Xk~EuvS5g4-OaH~KF7jy~zFIQ3MIRJ3klefTqBoQAzT7Z4r6NCpdGotWIeNiqhslo4TnOf4t3GpNf9mXPmWmIKshBzTPM3dmB3CilfEJ9zlp3MwGXWAm3qi6DUaVow5oJPJQ8pLV~FsLP9gyU3O8hEuDrNNlw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Peculiarities_of_Etiology_of_Respiratory_Virus_Infections_in_Hospitalized_Patients_Depending_on_the_Demographic_Socio_Economic_Factors_and_Previous_Vaccination","translated_slug":"","page_count":11,"language":"ru","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79394775"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79394775/Epidemic_Rise_of_Influenza_in_St_Petersburg_in_January_March_2018"><img alt="Research paper thumbnail of Epidemic Rise of Influenza in St. Petersburg in January-March 2018" class="work-thumbnail" src="https://attachments.academia-assets.com/86124556/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79394775/Epidemic_Rise_of_Influenza_in_St_Petersburg_in_January_March_2018">Epidemic Rise of Influenza in St. Petersburg in January-March 2018</a></div><div class="wp-workCard_item"><span>Russian Journal of Infection and Immunity</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="18b85897d091fb30e5c45c7f6ebedec2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124556,"asset_id":79394775,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124556/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394775; 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This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. The H7N3 live attenuated influenza vaccine demonstrated a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d7e2e8e302f4798dc4f3361a52305972" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124622,"asset_id":79394774,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124622/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394774"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394774"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394774; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394774]").text(description); $(".js-view-count[data-work-id=79394774]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394774; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394774']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394774, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d7e2e8e302f4798dc4f3361a52305972" } } $('.js-work-strip[data-work-id=79394774]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394774,"title":"Assessment of human immune responses to H7 avian influenza virus of pandemic potential: results from a placebo-controlled, randomized double-blind phase I study of live attenuated H7N3 influenza vaccine","translated_title":"","metadata":{"abstract":"Live attenuated influenza vaccines (LAIVs) are being developed to protect humans against future epidemics and pandemics. This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. The H7N3 live attenuated influenza vaccine demonstrated a...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PloS one"},"translated_abstract":"Live attenuated influenza vaccines (LAIVs) are being developed to protect humans against future epidemics and pandemics. This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. 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Biological properties of virus, such as susceptibility to antivirals, the clinical ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. Substitutions in YMDD-motif of the polymerase protein (M204I/V) as well as other primary and secondary resistance mutations to nucleotid...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b96c7b79e313183187b40bcdc672c4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124575,"asset_id":79394700,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124575/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394700; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394700]").text(description); $(".js-view-count[data-work-id=79394700]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394700; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394700']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394700, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5b96c7b79e313183187b40bcdc672c4d" } } $('.js-work-strip[data-work-id=79394700]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394700,"title":"ГЕНЕТИЧЕСКИЕ ВАРИАНТЫ ВИРУСА ГЕПАТИТА В У ПАЦИЕНТОВ С ХРОНИЧЕСКИМ ГЕПАТИТОМ В","translated_title":"","metadata":{"abstract":"Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. Substitutions in YMDD-motif of the polymerase protein (M204I/V) as well as other primary and secondary resistance mutations to nucleotid...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. 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HBV DNA was detected in 195 specimens. There were no serological markers of HBV in 8.2% of these sera, but later they were detected in patients&#39; sera. In patients without HBV DNA in the serum, specific HBV antigens and antibodies were detected in 62%. Only in 14% of them the clinical picture of the disease corresponded to acute viral hepatitis, although the blood for PCR analysis was collected during the late stages of the infection. The rest cases were referred to mixed hepatitis C + D. Comparison of the results of PCR test and detection of serological virus replication markers HBeAg and HBeAb showed the presence of HBV DNA in 28% cases without HBeAg.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003778; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003778]").text(description); $(".js-view-count[data-work-id=73003778]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003778; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003778']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003778, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003778]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003778,"title":"[Usage of polymerase chain reaction in complex diagnosis of hepatitis B]","translated_title":"","metadata":{"abstract":"Sera from 926 patients were analyzed by PCR using universal primers to surface gene of hepatitis B virus (HBV). 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Comparison of the results of PCR test and detection of serological virus replication markers HBeAg and HBeAb showed the presence of HBV DNA in 28% cases without HBeAg.","internal_url":"https://www.academia.edu/73003778/_Usage_of_polymerase_chain_reaction_in_complex_diagnosis_of_hepatitis_B_","translated_internal_url":"","created_at":"2022-03-04T00:53:21.896-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Usage_of_polymerase_chain_reaction_in_complex_diagnosis_of_hepatitis_B_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003775; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003775]").text(description); $(".js-view-count[data-work-id=73003775]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003775; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003775']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003775, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003775]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003775,"title":"[The Comparative Analysis of Effectiveness of Quick Tests in Diagnostic of Influenza and Respiratory Syncytial Viral Infection in Children]","translated_title":"","metadata":{"abstract":"The analysis was implemented concerning diagnostic parameters of commercial quick tests (immune chromatographic tests BinaxNOW Influenza A\u0026B and BinaxNow RSV Alere, Scarborough Inc., USA) under detection of antigens of influenza virus A and respiratory syncytial virus in clinical materials. The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...","publisher":"Klinicheskaia laboratornaia diagnostika","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Klinicheskaia laboratornaia diagnostika"},"translated_abstract":"The analysis was implemented concerning diagnostic parameters of commercial quick tests (immune chromatographic tests BinaxNOW Influenza A\u0026B and BinaxNow RSV Alere, Scarborough Inc., USA) under detection of antigens of influenza virus A and respiratory syncytial virus in clinical materials. The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...","internal_url":"https://www.academia.edu/73003775/_The_Comparative_Analysis_of_Effectiveness_of_Quick_Tests_in_Diagnostic_of_Influenza_and_Respiratory_Syncytial_Viral_Infection_in_Children_","translated_internal_url":"","created_at":"2022-03-04T00:53:21.551-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_The_Comparative_Analysis_of_Effectiveness_of_Quick_Tests_in_Diagnostic_of_Influenza_and_Respiratory_Syncytial_Viral_Infection_in_Children_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. Pisareva","url":"https://independent.academia.edu/MPisareva"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73003773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73003773/_The_Application_of_Dot_Technique_for_Detecting_Antigens_of_Adenovirus_in_Clinical_Samples_"><img alt="Research paper thumbnail of [The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73003773/_The_Application_of_Dot_Technique_for_Detecting_Antigens_of_Adenovirus_in_Clinical_Samples_">[The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]</a></div><div class="wp-workCard_item"><span>Klinicheskaia laboratornaia diagnostika</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The article substantiates possibility of application of point enzyme-linked immunosorbent assay (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. To diagnose adenovirus infection conjugate of virus-specific monoclonal antibodies and peroxidase of horse-radish were used The chromatographic rectification of conjugate from free peroxidase permits diminishing background coloring of nitrocellulose membrane and therefore to increase sensitivity. The application of direct conjugates on the basis of virus-specific monoclonal antibodies increases specifcity of dot-technique and significantly shortens time period of analysis. As in case of application of direct conjugates on the basis of polyclonal serum, samples from patients require preliminary processing with detergent for preventing non-specific reactions. The dot-technique demonstrates good coincidence with data of polymerase chain reaction and after clinical trials it can be used in diagnostic of human viral infecti...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003773]").text(description); $(".js-view-count[data-work-id=73003773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003773, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003773,"title":"[The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]","translated_title":"","metadata":{"abstract":"The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. 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The dot-technique demonstrates good coincidence with data of polymerase chain reaction and after clinical trials it can be used in diagnostic of human viral infecti...","publisher":"Klinicheskaia laboratornaia diagnostika","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Klinicheskaia laboratornaia diagnostika"},"translated_abstract":"The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. To diagnose adenovirus infection conjugate of virus-specific monoclonal antibodies and peroxidase of horse-radish were used The chromatographic rectification of conjugate from free peroxidase permits diminishing background coloring of nitrocellulose membrane and therefore to increase sensitivity. The application of direct conjugates on the basis of virus-specific monoclonal antibodies increases specifcity of dot-technique and significantly shortens time period of analysis. As in case of application of direct conjugates on the basis of polyclonal serum, samples from patients require preliminary processing with detergent for preventing non-specific reactions. 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Significant participati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of development influenza activity season 2010-2011 is presented. Significant participation of influenza A(H1N1)pdm09 virus and influenza B of Victoria lineage virus in the epidemic morbidity structure with minor participation ofA(H3N2) virus was revealed. The influenza viruses isolated in Russia according to antigenic properties were similar to the strains included in the vaccine composition. Drift variants of influenza A(H1N1)pdm09 viruses isolated in Astrakhan and St.-Petersburg were recognized using WHO CC in London as representatives of three new genetic groups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003770]").text(description); $(".js-view-count[data-work-id=73003770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003770, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003770]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003770,"title":"[Development of influenza surveillance in Russia in the system of the WHO national influenza center]","translated_title":"","metadata":{"abstract":"Analysis of development influenza activity season 2010-2011 is presented. 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MATERIALS AND METHODS Pandemic monitoring was performed by using results of integrative analysis of laboratory diagnostic and population morbidity data from 49 supporting bases of Federal center of influenza from various cities in Russian Federation. Isolation of influenza virus was carried out in MDCK cells and chicken embryos under BSL-3 conditions. Reference virus A/California/07/09 obtained from CDC (Atlanta, USA) and antisera against this strain contained in WHO kit were used for antigenic analysis; rat antisera, new monoclonal antibodies against pandemic influenza virus developed by Research institute of influenza were also used. RESULTS Based on PCR monitoring during epidemic peak, rate of pandemic influenza identification reached 45-49% of examined patients. About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003769]").text(description); $(".js-view-count[data-work-id=73003769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003769, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003769,"title":"[Analysis of pandemic influenza in Russia as a part of the global process based on data of an influenza monitoring reference center]","translated_title":"","metadata":{"abstract":"AIM Characterization of features of influenza pandemic development in Russia in relation to global process. 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About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...","publisher":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii"},"translated_abstract":"AIM Characterization of features of influenza pandemic development in Russia in relation to global process. MATERIALS AND METHODS Pandemic monitoring was performed by using results of integrative analysis of laboratory diagnostic and population morbidity data from 49 supporting bases of Federal center of influenza from various cities in Russian Federation. Isolation of influenza virus was carried out in MDCK cells and chicken embryos under BSL-3 conditions. Reference virus A/California/07/09 obtained from CDC (Atlanta, USA) and antisera against this strain contained in WHO kit were used for antigenic analysis; rat antisera, new monoclonal antibodies against pandemic influenza virus developed by Research institute of influenza were also used. RESULTS Based on PCR monitoring during epidemic peak, rate of pandemic influenza identification reached 45-49% of examined patients. About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...","internal_url":"https://www.academia.edu/73003769/_Analysis_of_pandemic_influenza_in_Russia_as_a_part_of_the_global_process_based_on_data_of_an_influenza_monitoring_reference_center_","translated_internal_url":"","created_at":"2022-03-04T00:53:20.654-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Analysis_of_pandemic_influenza_in_Russia_as_a_part_of_the_global_process_based_on_data_of_an_influenza_monitoring_reference_center_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003766]").text(description); $(".js-view-count[data-work-id=73003766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003766, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003766,"title":"Influence of Influenza a Virus and Bacterial Lipopolysaccharide on Proliferation and Gene Expression of Cytokines and Other Cellular Factors in Cells of Established Endothelial Cell Line ECV-304","translated_title":"","metadata":{"abstract":"Change of state of endothelial cells occurs under the action of viral infection and bacterial lipopolysaccharide (LPS) that leads to cell dysfunction. Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...","publisher":"Tsitologiia","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Change of state of endothelial cells occurs under the action of viral infection and bacterial lipopolysaccharide (LPS) that leads to cell dysfunction. Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...","internal_url":"https://www.academia.edu/73003766/Influence_of_Influenza_a_Virus_and_Bacterial_Lipopolysaccharide_on_Proliferation_and_Gene_Expression_of_Cytokines_and_Other_Cellular_Factors_in_Cells_of_Established_Endothelial_Cell_Line_ECV_304","translated_internal_url":"","created_at":"2022-03-04T00:53:19.740-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Influence_of_Influenza_a_Virus_and_Bacterial_Lipopolysaccharide_on_Proliferation_and_Gene_Expression_of_Cytokines_and_Other_Cellular_Factors_in_Cells_of_Established_Endothelial_Cell_Line_ECV_304","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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For identification of the virus neutralizing epitopes in HA1 escape mutants (EM) of the influenza BIShandong/07/97 and B/Malaysia/2506/04 virus were selected using virus- neutralizing antibodies (MAbs). Three EMs had single, two--double and one--triple amino acid substitutions (AAS) in HA1 (H122N, A202E, K203T, K2031, K203N or A317V). In addition, AAS N197S was detected in three EMs. A correlation of AAS identified with peculiarities of interaction of EMs with Mabs was discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003765]").text(description); $(".js-view-count[data-work-id=73003765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003765,"title":"[Epitope analysis of the hemagglutinin molecule of the Victoria lineage influenza B viruses]","translated_title":"","metadata":{"abstract":"A panel of five monoclonal antibodies (MAbs) to the HA1 molecule of the influenza B virus of the Victorian lineage with high virus-neutralizing activity was developed. For identification of the virus neutralizing epitopes in HA1 escape mutants (EM) of the influenza BIShandong/07/97 and B/Malaysia/2506/04 virus were selected using virus- neutralizing antibodies (MAbs). Three EMs had single, two--double and one--triple amino acid substitutions (AAS) in HA1 (H122N, A202E, K203T, K2031, K203N or A317V). In addition, AAS N197S was detected in three EMs. A correlation of AAS identified with peculiarities of interaction of EMs with Mabs was discussed.","publisher":"Voprosy virusologii","publication_date":{"day":null,"month":null,"year":2014,"errors":{}}},"translated_abstract":"A panel of five monoclonal antibodies (MAbs) to the HA1 molecule of the influenza B virus of the Victorian lineage with high virus-neutralizing activity was developed. For identification of the virus neutralizing epitopes in HA1 escape mutants (EM) of the influenza BIShandong/07/97 and B/Malaysia/2506/04 virus were selected using virus- neutralizing antibodies (MAbs). Three EMs had single, two--double and one--triple amino acid substitutions (AAS) in HA1 (H122N, A202E, K203T, K2031, K203N or A317V). 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At the same time in 2009-2011 was marked significant prevalence of pandemic influenza virus infection A(Н1N1)v in a kind mono- and mikst-infections (in 18,8 and 10,2 % of cases accordingly), and adenoviruses, espiratory sincitial viruses and parainfluenza were the most frequent concomitants (in 4,8, 3,2 and 2,4 % of cases). In a clinical picture of disease acute nasopharynx lesion (67,8 %) was predominated, complicating by croup in 12,2 % of cases, by acute bronchitis in 12,1 % of cases, and more rare by pneumonia (in 8,2 % of cases). The analysis of results of immunofluorescence test in comparison with the cumulative data of other laboratory methods (polymerase chain reaction, immuneenzyme analysis, virus isolation, serological examination) has shown possibility of discovery with its help the valua...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="9a069e24efbb52101066d4a0ca7a6554" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":98318879,"asset_id":96414087,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/98318879/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="96414087"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="96414087"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 96414087; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=96414087]").text(description); $(".js-view-count[data-work-id=96414087]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 96414087; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='96414087']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 96414087, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "9a069e24efbb52101066d4a0ca7a6554" } } $('.js-work-strip[data-work-id=96414087]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":96414087,"title":"ЛАБОРАТОРНАЯ ДИАГНОСТИКА ОСТРЫХ РЕСПИРАТОРНЫХ ВИРУСНЫХ ИНФЕКЦИЙ В УСЛОВИЯХ ЭВОЛЮЦИОННОЙ ИЗМЕНЧИВОСТИ ВИРУСОВ ГРИППА","translated_title":"","metadata":{"abstract":"As a result of laboratory investigation 1651 patients at the age from 0 months till 18 years, hospitalized with ARI from 2008 to 2011, in ¾ cases the virus etiology of disease was found. 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The analysis of results of immunofluorescence test in comparison with the cumulative data of other laboratory methods (polymerase chain reaction, immuneenzyme analysis, virus isolation, serological examination) has shown possibility of discovery with its help the valua...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}}},"translated_abstract":"As a result of laboratory investigation 1651 patients at the age from 0 months till 18 years, hospitalized with ARI from 2008 to 2011, in ¾ cases the virus etiology of disease was found. At the same time in 2009-2011 was marked significant prevalence of pandemic influenza virus infection A(Н1N1)v in a kind mono- and mikst-infections (in 18,8 and 10,2 % of cases accordingly), and adenoviruses, espiratory sincitial viruses and parainfluenza were the most frequent concomitants (in 4,8, 3,2 and 2,4 % of cases). 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The analysis of results of immunofluorescence test in comparison with the cumulative data of other laboratory methods (polymerase chain reaction, immuneenzyme analysis, virus isolation, serological examination) has shown possibility of discovery with its help the valua...","internal_url":"https://www.academia.edu/96414087/%D0%9B%D0%90%D0%91%D0%9E%D0%A0%D0%90%D0%A2%D0%9E%D0%A0%D0%9D%D0%90%D0%AF_%D0%94%D0%98%D0%90%D0%93%D0%9D%D0%9E%D0%A1%D0%A2%D0%98%D0%9A%D0%90_%D0%9E%D0%A1%D0%A2%D0%A0%D0%AB%D0%A5_%D0%A0%D0%95%D0%A1%D0%9F%D0%98%D0%A0%D0%90%D0%A2%D0%9E%D0%A0%D0%9D%D0%AB%D0%A5_%D0%92%D0%98%D0%A0%D0%A3%D0%A1%D0%9D%D0%AB%D0%A5_%D0%98%D0%9D%D0%A4%D0%95%D0%9A%D0%A6%D0%98%D0%99_%D0%92_%D0%A3%D0%A1%D0%9B%D0%9E%D0%92%D0%98%D0%AF%D0%A5_%D0%AD%D0%92%D0%9E%D0%9B%D0%AE%D0%A6%D0%98%D0%9E%D0%9D%D0%9D%D0%9E%D0%99_%D0%98%D0%97%D0%9C%D0%95%D0%9D%D0%A7%D0%98%D0%92%D0%9E%D0%A1%D0%A2%D0%98_%D0%92%D0%98%D0%A0%D0%A3%D0%A1%D0%9E%D0%92_%D0%93%D0%A0%D0%98%D0%9F%D0%9F%D0%90","translated_internal_url":"","created_at":"2023-02-06T08:04:12.838-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":98318879,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/98318879/thumbnails/1.jpg","file_name":"78.pdf","download_url":"https://www.academia.edu/attachments/98318879/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"98318879.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/98318879/78-libre.pdf?1675701069=\u0026response-content-disposition=attachment%3B+filename%3D98318879.pdf\u0026Expires=1733019525\u0026Signature=TTAxL-SkAqHGLuVuboCqDHx87UA33sbt0c0oM~RHzEw9TsV1J8cgcJfR7B1mH8L5HAPTqyK64z8YeuUsf8xhSb7uD67-~G3527kNUsAiX0kevpBM8GGAZENzaeXrEuFoZ11tYOMkfmUIHTdNT7nF~GMBA8O3aYSPIBJ5NyGkrw8O-MmRDJdDkYJIjlfxORwCEhWlwwiB5t3Z-3-IKtK64wUxXLS3uMFfo~TUX8K08SU07mK1IsiTclW6KkIm3EzuHj4sIUSF-0VW2p8YQ2oNPPwTiDvGR9EjZCbH81Nl7p9seezXeyxdkTpk3xCRRwq7uM5JjcxCLJYLBNQC4eoixw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"ЛАБОРАТОРНАЯ_ДИАГНОСТИКА_ОСТРЫХ_РЕСПИРАТОРНЫХ_ВИРУСНЫХ_ИНФЕКЦИЙ_В_УСЛОВИЯХ_ЭВОЛЮЦИОННОЙ_ИЗМЕНЧИВОСТИ_ВИРУСОВ_ГРИППА","translated_slug":"","page_count":6,"language":"ru","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88730985"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88730985/Development_of_the_cell_ELISA_test_for_the_subtype_identification_of_circulating_influenza_A_H1_and_A_H3_viruses"><img alt="Research paper thumbnail of Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses" class="work-thumbnail" src="https://attachments.academia-assets.com/92650882/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88730985/Development_of_the_cell_ELISA_test_for_the_subtype_identification_of_circulating_influenza_A_H1_and_A_H3_viruses">Development of the cell-ELISA test for the subtype identification of circulating influenza A(H1) and A(H3) viruses</a></div><div class="wp-workCard_item"><span>Microbiology Independent Research journal</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4c74a55c5cb072b6ddd81caf39b48cdc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":92650882,"asset_id":88730985,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/92650882/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88730985"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88730985"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88730985; 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This method is based on the estimation of virus reproduction in infected MDCK cells. The detection step of this method is an interaction of the subtype-specific monoclonal antibodies (mAbs) with the viral hemagglutinin (НА) molecule. The influenza A virus strains, isolated in the 2014 epidemic season, were used to validate this method. It was shown that when using mAbs # 1/ # 2 or # 4 at a concentration of 10-15 µg/ml, the developed variant of cell-ELISA was able to detect НА protein synthesized in the infected cells of influenza A(H3N2) and A(H1N1)pdm09 viruses, respectively. The developed method can be used for the identification of modern influenza A viruses with low hemagglutination activity, which is not possible by the conventional hemagglutination inhibition test.","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Microbiology Independent Research journal","grobid_abstract_attachment_id":92650882},"translated_abstract":null,"internal_url":"https://www.academia.edu/88730985/Development_of_the_cell_ELISA_test_for_the_subtype_identification_of_circulating_influenza_A_H1_and_A_H3_viruses","translated_internal_url":"","created_at":"2022-10-18T08:08:05.051-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":92650882,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/92650882/thumbnails/1.jpg","file_name":"02_08_krivizkaja_en-2.pdf","download_url":"https://www.academia.edu/attachments/92650882/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Development_of_the_cell_ELISA_test_for_t.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/92650882/02_08_krivizkaja_en-2-libre.pdf?1666106819=\u0026response-content-disposition=attachment%3B+filename%3DDevelopment_of_the_cell_ELISA_test_for_t.pdf\u0026Expires=1733019525\u0026Signature=OKYnS3ro9aTbA4KYAYwFobeyA47iM1E9HrTvzHg6IO2VWFw1aok-N12Ul6V401~wMkg-SUy5K0VytGRcKKTouWxtPgW23YNTk~dOLa0-u1c2ZbGvVzTzS37m6s3SebJdPf5k-QjwnSo3zFjR1sooBPTGj5BxUNipCPH1xg6ChNzbI3a~XRhDU7HS3hlaqadPz7~X8HpV3beRKstspJHMiy2ZvKG4Rg9PyApgyiT2uSIaywLR0d~LJaweFpIfwPg0JYRy2Xxd1AELZozC6Lq7HsLK0jhyNM9J1zGKlsCsPiShi~P1S-xXUTKhG15DL8XrI678nm0vX0ol94Nmib0S~Q__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Development_of_the_cell_ELISA_test_for_the_subtype_identification_of_circulating_influenza_A_H1_and_A_H3_viruses","translated_slug":"","page_count":4,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="88730930"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/88730930/%D0%98%D1%81%D0%BF%D0%BE%D0%BB%D1%8C%D0%B7%D0%BE%D0%B2%D0%B0%D0%BD%D0%B8%D0%B5_%D0%BC%D0%B8%D0%BA%D1%80%D0%BE%D0%BA%D1%83%D0%BB%D1%8C%D1%82%D1%83%D1%80%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D1%84%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B0%D0%BD%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0_%D0%B4%D0%BB%D1%8F_%D1%81%D1%83%D0%B1%D1%82%D0%B8%D0%BF%D0%BE%D0%B2%D0%BE%D0%B9_%D0%B8%D0%B4%D0%B5%D0%BD%D1%82%D0%B8%D1%84%D0%B8%D0%BA%D0%B0%D1%86%D0%B8%D0%B8_%D1%86%D0%B8%D1%80%D0%BA%D1%83%D0%BB%D0%B8%D1%80%D1%83%D1%8E%D1%89%D0%B8%D1%85_%D0%B2%D0%B8%D1%80%D1%83%D1%81%D0%BE%D0%B2_%D0%B3%D1%80%D0%B8%D0%BF%D0%BF%D0%B0_%D0%90_%D0%9D1_%D0%B8_%D0%90_%D0%9D3_"><img alt="Research paper thumbnail of Использование микрокультурального иммуноферментного анализа для субтиповой идентификации циркулирующих вирусов гриппа А(Н1) и А(Н3)" class="work-thumbnail" src="https://attachments.academia-assets.com/92650846/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/88730930/%D0%98%D1%81%D0%BF%D0%BE%D0%BB%D1%8C%D0%B7%D0%BE%D0%B2%D0%B0%D0%BD%D0%B8%D0%B5_%D0%BC%D0%B8%D0%BA%D1%80%D0%BE%D0%BA%D1%83%D0%BB%D1%8C%D1%82%D1%83%D1%80%D0%B0%D0%BB%D1%8C%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B8%D0%BC%D0%BC%D1%83%D0%BD%D0%BE%D1%84%D0%B5%D1%80%D0%BC%D0%B5%D0%BD%D1%82%D0%BD%D0%BE%D0%B3%D0%BE_%D0%B0%D0%BD%D0%B0%D0%BB%D0%B8%D0%B7%D0%B0_%D0%B4%D0%BB%D1%8F_%D1%81%D1%83%D0%B1%D1%82%D0%B8%D0%BF%D0%BE%D0%B2%D0%BE%D0%B9_%D0%B8%D0%B4%D0%B5%D0%BD%D1%82%D0%B8%D1%84%D0%B8%D0%BA%D0%B0%D1%86%D0%B8%D0%B8_%D1%86%D0%B8%D1%80%D0%BA%D1%83%D0%BB%D0%B8%D1%80%D1%83%D1%8E%D1%89%D0%B8%D1%85_%D0%B2%D0%B8%D1%80%D1%83%D1%81%D0%BE%D0%B2_%D0%B3%D1%80%D0%B8%D0%BF%D0%BF%D0%B0_%D0%90_%D0%9D1_%D0%B8_%D0%90_%D0%9D3_">Использование микрокультурального иммуноферментного анализа для субтиповой идентификации циркулирующих вирусов гриппа А(Н1) и А(Н3)</a></div><div class="wp-workCard_item"><span>Microbiology Independent Research journal</span><span>, 2015</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="c2c8abf1e6bdfff77ae43c9745c530fe" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":92650846,"asset_id":88730930,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/92650846/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="88730930"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="88730930"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 88730930; 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The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). Respiratory syncytial virus and rhinoviruses were detected the most regularly (8.7 and 3.1%, correspondingly) in children, parainfluenza and adenoviruses were registered rarely (1.4 and 2.1%, correspondingly). Rate of detection of coronaviruses and bocavirus was low and varied in the range 0.3 - 0.6%. Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="80bbaa002fd7a442145514e9fab3cefc" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124557,"asset_id":79394776,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124557/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394776"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394776"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394776; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394776]").text(description); $(".js-view-count[data-work-id=79394776]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394776; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394776']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394776, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "80bbaa002fd7a442145514e9fab3cefc" } } $('.js-work-strip[data-work-id=79394776]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394776,"title":"Peculiarities of Etiology of Respiratory Virus Infections in Hospitalized Patients Depending on the Demographic, Socio-Economic Factors and Previous Vaccination","translated_title":"","metadata":{"abstract":"Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. 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Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...","publisher":"LLC Numicom","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Epidemiology and Vaccine Prevention"},"translated_abstract":"Etiology of respiratory virus infections among 1699 hospitalized patients (HP) was determined by PCR during the period of increased influenza activity in 2012 - 2013 season. The rate of accidence of influenza virus in dependence of gender, age, social and demographic factors and previous vaccination was analysed. Young children dominated in the age structure of HP, while the elderly were hospitalized very rarely. According to results obtained rate of influenza detection in HP was significantly higher among adults in comparison with children (63,5 and 30,7% of investigated patients, correspondingly). 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Indicated above ARI agents among hospitalized adults were detected rarely (0 - 1.5%) wi...","internal_url":"https://www.academia.edu/79394776/Peculiarities_of_Etiology_of_Respiratory_Virus_Infections_in_Hospitalized_Patients_Depending_on_the_Demographic_Socio_Economic_Factors_and_Previous_Vaccination","translated_internal_url":"","created_at":"2022-05-18T10:30:18.261-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[{"id":86124557,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/86124557/thumbnails/1.jpg","file_name":"62.pdf","download_url":"https://www.academia.edu/attachments/86124557/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Peculiarities_of_Etiology_of_Respiratory.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/86124557/62-libre.pdf?1652895593=\u0026response-content-disposition=attachment%3B+filename%3DPeculiarities_of_Etiology_of_Respiratory.pdf\u0026Expires=1733019525\u0026Signature=Mfl1cNUEGFCxNQGzLwFhTYw~6NU5cpAshJ3PvXRY2RKRMAP4tw~z9x6eG6B1Q9x2Tb~KM3AcXvl~ChmBe0W8Psp2CQ959Ig5H0D5TOytnYIntVRY70HP4lzrLbbGcvOVg-cdyHxNwzqkF2fj~R~BBT2Mbk~xlUVKZQas1NoO8lnxJnJO1SKiikZx4Xk~EuvS5g4-OaH~KF7jy~zFIQ3MIRJ3klefTqBoQAzT7Z4r6NCpdGotWIeNiqhslo4TnOf4t3GpNf9mXPmWmIKshBzTPM3dmB3CilfEJ9zlp3MwGXWAm3qi6DUaVow5oJPJQ8pLV~FsLP9gyU3O8hEuDrNNlw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Peculiarities_of_Etiology_of_Respiratory_Virus_Infections_in_Hospitalized_Patients_Depending_on_the_Demographic_Socio_Economic_Factors_and_Previous_Vaccination","translated_slug":"","page_count":11,"language":"ru","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="79394775"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/79394775/Epidemic_Rise_of_Influenza_in_St_Petersburg_in_January_March_2018"><img alt="Research paper thumbnail of Epidemic Rise of Influenza in St. Petersburg in January-March 2018" class="work-thumbnail" src="https://attachments.academia-assets.com/86124556/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/79394775/Epidemic_Rise_of_Influenza_in_St_Petersburg_in_January_March_2018">Epidemic Rise of Influenza in St. Petersburg in January-March 2018</a></div><div class="wp-workCard_item"><span>Russian Journal of Infection and Immunity</span><span>, 2019</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="18b85897d091fb30e5c45c7f6ebedec2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124556,"asset_id":79394775,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124556/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394775; 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This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. The H7N3 live attenuated influenza vaccine demonstrated a...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="d7e2e8e302f4798dc4f3361a52305972" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124622,"asset_id":79394774,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124622/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394774"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394774"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394774; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394774]").text(description); $(".js-view-count[data-work-id=79394774]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394774; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394774']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394774, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "d7e2e8e302f4798dc4f3361a52305972" } } $('.js-work-strip[data-work-id=79394774]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394774,"title":"Assessment of human immune responses to H7 avian influenza virus of pandemic potential: results from a placebo-controlled, randomized double-blind phase I study of live attenuated H7N3 influenza vaccine","translated_title":"","metadata":{"abstract":"Live attenuated influenza vaccines (LAIVs) are being developed to protect humans against future epidemics and pandemics. This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. The H7N3 live attenuated influenza vaccine demonstrated a...","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"PloS one"},"translated_abstract":"Live attenuated influenza vaccines (LAIVs) are being developed to protect humans against future epidemics and pandemics. This study describes the results of a double-blinded randomized placebo-controlled phase I clinical trial of cold-adapted and temperature sensitive H7N3 live attenuated influenza vaccine candidate in healthy seronegative adults. The goal of the study was to evaluate the safety, tolerability, immunogenicity and potential shedding and transmission of H7N3 LAIV against H7 avian influenza virus of pandemic potential. Two doses of H7N3 LAIV or placebo were administered to 40 randomly divided subjects (30 received vaccine and 10 placebo). The presence of influenza A virus RNA in nasal swabs was detected in 60.0% and 51.7% of subjects after the first and second vaccination, respectively. In addition, vaccine virus was not detected among placebo recipients demonstrating the absence of person-to-person transmission. 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Biological properties of virus, such as susceptibility to antivirals, the clinical ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. Substitutions in YMDD-motif of the polymerase protein (M204I/V) as well as other primary and secondary resistance mutations to nucleotid...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="5b96c7b79e313183187b40bcdc672c4d" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":86124575,"asset_id":79394700,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/86124575/download_file?st=MTczMzAzNzAxOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="79394700"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="79394700"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 79394700; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=79394700]").text(description); $(".js-view-count[data-work-id=79394700]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 79394700; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='79394700']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 79394700, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "5b96c7b79e313183187b40bcdc672c4d" } } $('.js-work-strip[data-work-id=79394700]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":79394700,"title":"ГЕНЕТИЧЕСКИЕ ВАРИАНТЫ ВИРУСА ГЕПАТИТА В У ПАЦИЕНТОВ С ХРОНИЧЕСКИМ ГЕПАТИТОМ В","translated_title":"","metadata":{"abstract":"Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. Substitutions in YMDD-motif of the polymerase protein (M204I/V) as well as other primary and secondary resistance mutations to nucleotid...","publication_date":{"day":null,"month":null,"year":2015,"errors":{}}},"translated_abstract":"Introduction. Biological properties of virus, such as susceptibility to antivirals, the clinical course of chronic hepatitis B (CHB), the probability of developing cirrhosis and hepatocellular carcinoma are determined by genotype and mutations in the genome of the hepatitis B virus (HBV). The aim of the study was evaluating of HBV genetic variants in patients with CHB from St. Petersburg hospitals. Material and methods. A total of 1414 CHB patients with positive polymerase chain reaction HBV genome in blood and/or liver tissue were observed. Genotype was determined in 298 patients, sequencing of the polymerase gene fragment was performed in 80 patients. Results. Viral DNA was detected in 323 (55.8%) patients with CHB. Genotype D was determined in 238 (80,1%), genotype A – in 49 (16,5%), C genotype – in 2 (0,7%) and mixed A+D – in 8 (2,7%) patients. 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HBV DNA was detected in 195 specimens. There were no serological markers of HBV in 8.2% of these sera, but later they were detected in patients&#39; sera. In patients without HBV DNA in the serum, specific HBV antigens and antibodies were detected in 62%. Only in 14% of them the clinical picture of the disease corresponded to acute viral hepatitis, although the blood for PCR analysis was collected during the late stages of the infection. The rest cases were referred to mixed hepatitis C + D. Comparison of the results of PCR test and detection of serological virus replication markers HBeAg and HBeAb showed the presence of HBV DNA in 28% cases without HBeAg.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003778"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003778"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003778; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003778]").text(description); $(".js-view-count[data-work-id=73003778]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003778; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003778']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003778, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003778]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003778,"title":"[Usage of polymerase chain reaction in complex diagnosis of hepatitis B]","translated_title":"","metadata":{"abstract":"Sera from 926 patients were analyzed by PCR using universal primers to surface gene of hepatitis B virus (HBV). 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Comparison of the results of PCR test and detection of serological virus replication markers HBeAg and HBeAb showed the presence of HBV DNA in 28% cases without HBeAg.","internal_url":"https://www.academia.edu/73003778/_Usage_of_polymerase_chain_reaction_in_complex_diagnosis_of_hepatitis_B_","translated_internal_url":"","created_at":"2022-03-04T00:53:21.896-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Usage_of_polymerase_chain_reaction_in_complex_diagnosis_of_hepatitis_B_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003775"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003775"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003775; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003775]").text(description); $(".js-view-count[data-work-id=73003775]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003775; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003775']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003775, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003775]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003775,"title":"[The Comparative Analysis of Effectiveness of Quick Tests in Diagnostic of Influenza and Respiratory Syncytial Viral Infection in Children]","translated_title":"","metadata":{"abstract":"The analysis was implemented concerning diagnostic parameters of commercial quick tests (immune chromatographic tests BinaxNOW Influenza A\u0026B and BinaxNow RSV Alere, Scarborough Inc., USA) under detection of antigens of influenza virus A and respiratory syncytial virus in clinical materials. The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...","publisher":"Klinicheskaia laboratornaia diagnostika","publication_date":{"day":null,"month":null,"year":2015,"errors":{}},"publication_name":"Klinicheskaia laboratornaia diagnostika"},"translated_abstract":"The analysis was implemented concerning diagnostic parameters of commercial quick tests (immune chromatographic tests BinaxNOW Influenza A\u0026B and BinaxNow RSV Alere, Scarborough Inc., USA) under detection of antigens of influenza virus A and respiratory syncytial virus in clinical materials. The polymerase chain reaction in real-time and isolation ofviruses in cell cultures. The analysis of naso-pharyngeal smears from 116 children demonstrated that sensitivity and specifcity of detection of influenza virus A using device mariPOC in comparison with polymerase chain reaction made up to 93.8% and 99.0% correspondingly at total concordance of results of both techniques as 98.3%. At diagnosing of respiratory syncytial virus using device mariPOC parameters made up to 77.3%, 98.9% and 862% as compared with polymerase chain reaction. The sensitivity, specificity and total concordance of results of immune chromatographic tests BinaxNOW in comparison ofpolymerase chain reaction made up to 86.7...","internal_url":"https://www.academia.edu/73003775/_The_Comparative_Analysis_of_Effectiveness_of_Quick_Tests_in_Diagnostic_of_Influenza_and_Respiratory_Syncytial_Viral_Infection_in_Children_","translated_internal_url":"","created_at":"2022-03-04T00:53:21.551-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_The_Comparative_Analysis_of_Effectiveness_of_Quick_Tests_in_Diagnostic_of_Influenza_and_Respiratory_Syncytial_Viral_Infection_in_Children_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. Pisareva","url":"https://independent.academia.edu/MPisareva"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"}],"urls":[]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="73003773"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/73003773/_The_Application_of_Dot_Technique_for_Detecting_Antigens_of_Adenovirus_in_Clinical_Samples_"><img alt="Research paper thumbnail of [The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/73003773/_The_Application_of_Dot_Technique_for_Detecting_Antigens_of_Adenovirus_in_Clinical_Samples_">[The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]</a></div><div class="wp-workCard_item"><span>Klinicheskaia laboratornaia diagnostika</span><span>, 2016</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The article substantiates possibility of application of point enzyme-linked immunosorbent assay (...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. To diagnose adenovirus infection conjugate of virus-specific monoclonal antibodies and peroxidase of horse-radish were used The chromatographic rectification of conjugate from free peroxidase permits diminishing background coloring of nitrocellulose membrane and therefore to increase sensitivity. The application of direct conjugates on the basis of virus-specific monoclonal antibodies increases specifcity of dot-technique and significantly shortens time period of analysis. As in case of application of direct conjugates on the basis of polyclonal serum, samples from patients require preliminary processing with detergent for preventing non-specific reactions. The dot-technique demonstrates good coincidence with data of polymerase chain reaction and after clinical trials it can be used in diagnostic of human viral infecti...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003773"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003773"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003773; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003773]").text(description); $(".js-view-count[data-work-id=73003773]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003773; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003773']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003773, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003773]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003773,"title":"[The Application of Dot-Technique for Detecting Antigens of Adenovirus in Clinical Samples]","translated_title":"","metadata":{"abstract":"The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. 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The dot-technique demonstrates good coincidence with data of polymerase chain reaction and after clinical trials it can be used in diagnostic of human viral infecti...","publisher":"Klinicheskaia laboratornaia diagnostika","publication_date":{"day":null,"month":null,"year":2016,"errors":{}},"publication_name":"Klinicheskaia laboratornaia diagnostika"},"translated_abstract":"The article substantiates possibility of application of point enzyme-linked immunosorbent assay (dot-technique) for detecting viral antigens in samples from patients. To diagnose adenovirus infection conjugate of virus-specific monoclonal antibodies and peroxidase of horse-radish were used The chromatographic rectification of conjugate from free peroxidase permits diminishing background coloring of nitrocellulose membrane and therefore to increase sensitivity. The application of direct conjugates on the basis of virus-specific monoclonal antibodies increases specifcity of dot-technique and significantly shortens time period of analysis. As in case of application of direct conjugates on the basis of polyclonal serum, samples from patients require preliminary processing with detergent for preventing non-specific reactions. 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Significant participati...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Analysis of development influenza activity season 2010-2011 is presented. Significant participation of influenza A(H1N1)pdm09 virus and influenza B of Victoria lineage virus in the epidemic morbidity structure with minor participation ofA(H3N2) virus was revealed. The influenza viruses isolated in Russia according to antigenic properties were similar to the strains included in the vaccine composition. Drift variants of influenza A(H1N1)pdm09 viruses isolated in Astrakhan and St.-Petersburg were recognized using WHO CC in London as representatives of three new genetic groups.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003770"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003770"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003770; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003770]").text(description); $(".js-view-count[data-work-id=73003770]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003770; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003770']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003770, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003770]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003770,"title":"[Development of influenza surveillance in Russia in the system of the WHO national influenza center]","translated_title":"","metadata":{"abstract":"Analysis of development influenza activity season 2010-2011 is presented. 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MATERIALS AND METHODS Pandemic monitoring was performed by using results of integrative analysis of laboratory diagnostic and population morbidity data from 49 supporting bases of Federal center of influenza from various cities in Russian Federation. Isolation of influenza virus was carried out in MDCK cells and chicken embryos under BSL-3 conditions. Reference virus A/California/07/09 obtained from CDC (Atlanta, USA) and antisera against this strain contained in WHO kit were used for antigenic analysis; rat antisera, new monoclonal antibodies against pandemic influenza virus developed by Research institute of influenza were also used. RESULTS Based on PCR monitoring during epidemic peak, rate of pandemic influenza identification reached 45-49% of examined patients. About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003769"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003769"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003769; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003769]").text(description); $(".js-view-count[data-work-id=73003769]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003769; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003769']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003769, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003769]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003769,"title":"[Analysis of pandemic influenza in Russia as a part of the global process based on data of an influenza monitoring reference center]","translated_title":"","metadata":{"abstract":"AIM Characterization of features of influenza pandemic development in Russia in relation to global process. 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About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...","publisher":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii","publication_date":{"day":null,"month":null,"year":2011,"errors":{}},"publication_name":"Zhurnal mikrobiologii, epidemiologii, i immunobiologii"},"translated_abstract":"AIM Characterization of features of influenza pandemic development in Russia in relation to global process. MATERIALS AND METHODS Pandemic monitoring was performed by using results of integrative analysis of laboratory diagnostic and population morbidity data from 49 supporting bases of Federal center of influenza from various cities in Russian Federation. Isolation of influenza virus was carried out in MDCK cells and chicken embryos under BSL-3 conditions. Reference virus A/California/07/09 obtained from CDC (Atlanta, USA) and antisera against this strain contained in WHO kit were used for antigenic analysis; rat antisera, new monoclonal antibodies against pandemic influenza virus developed by Research institute of influenza were also used. RESULTS Based on PCR monitoring during epidemic peak, rate of pandemic influenza identification reached 45-49% of examined patients. About 53% of lethal cases of respiratory infections were caused by pandemic influenza virus, while predominately...","internal_url":"https://www.academia.edu/73003769/_Analysis_of_pandemic_influenza_in_Russia_as_a_part_of_the_global_process_based_on_data_of_an_influenza_monitoring_reference_center_","translated_internal_url":"","created_at":"2022-03-04T00:53:20.654-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"_Analysis_of_pandemic_influenza_in_Russia_as_a_part_of_the_global_process_based_on_data_of_an_influenza_monitoring_reference_center_","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003766"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003766"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003766; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003766]").text(description); $(".js-view-count[data-work-id=73003766]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003766; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003766']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003766, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003766]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003766,"title":"Influence of Influenza a Virus and Bacterial Lipopolysaccharide on Proliferation and Gene Expression of Cytokines and Other Cellular Factors in Cells of Established Endothelial Cell Line ECV-304","translated_title":"","metadata":{"abstract":"Change of state of endothelial cells occurs under the action of viral infection and bacterial lipopolysaccharide (LPS) that leads to cell dysfunction. Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...","publisher":"Tsitologiia","publication_date":{"day":null,"month":null,"year":2016,"errors":{}}},"translated_abstract":"Change of state of endothelial cells occurs under the action of viral infection and bacterial lipopolysaccharide (LPS) that leads to cell dysfunction. Therefore, the aim of the current study was to investigate the effect of LPS from Escherichia coli and influenza A virus on proliferative activity of human endothelial cells (ECV-304) and gene expression of several cytokines and cellular factors: TNFá, TGFâ, IFN-ã, MMP-9, NF-êB, Rho A, eNOS and iNOS. It was found that ECV-304 cells once infected with very low infectious doses of influenza virus acquire the ability to long-term active proliferation (over 8 passages). Addition of LPS E. coli reduced the virus-stimulated cell proliferation. It was shown that influenza virus and LPS can affect on gene expression of cytokine and other cellular factors. When endothelial cells had been infected with influenza A virus in the presence of LPS, there was a significant increase in the expression of several genes and replacement of some genes expr...","internal_url":"https://www.academia.edu/73003766/Influence_of_Influenza_a_Virus_and_Bacterial_Lipopolysaccharide_on_Proliferation_and_Gene_Expression_of_Cytokines_and_Other_Cellular_Factors_in_Cells_of_Established_Endothelial_Cell_Line_ECV_304","translated_internal_url":"","created_at":"2022-03-04T00:53:19.740-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":57386529,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Influence_of_Influenza_a_Virus_and_Bacterial_Lipopolysaccharide_on_Proliferation_and_Gene_Expression_of_Cytokines_and_Other_Cellular_Factors_in_Cells_of_Established_Endothelial_Cell_Line_ECV_304","translated_slug":"","page_count":null,"language":"en","content_type":"Work","owner":{"id":57386529,"first_name":"M.","middle_initials":null,"last_name":"Pisareva","page_name":"MPisareva","domain_name":"independent","created_at":"2016-11-29T02:31:34.446-08:00","display_name":"M. 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For identification of the virus neutralizing epitopes in HA1 escape mutants (EM) of the influenza BIShandong/07/97 and B/Malaysia/2506/04 virus were selected using virus- neutralizing antibodies (MAbs). Three EMs had single, two--double and one--triple amino acid substitutions (AAS) in HA1 (H122N, A202E, K203T, K2031, K203N or A317V). In addition, AAS N197S was detected in three EMs. A correlation of AAS identified with peculiarities of interaction of EMs with Mabs was discussed.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="73003765"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="73003765"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 73003765; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=73003765]").text(description); $(".js-view-count[data-work-id=73003765]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 73003765; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='73003765']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 73003765, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=73003765]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":73003765,"title":"[Epitope analysis of the hemagglutinin molecule of the Victoria lineage influenza B viruses]","translated_title":"","metadata":{"abstract":"A panel of five monoclonal antibodies (MAbs) to the HA1 molecule of the influenza B virus of the Victorian lineage with high virus-neutralizing activity was developed. 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