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Journal of Neuroscience

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src="https://www.jneurosci.org/sites/default/files/styles/large/public/highwire/jneuro/44/48.cover-source.jpg?itok=CjIRIFvd" alt="The Journal of Neuroscience: 44 (48)" /></a></div></div> </div> </div> </div> </div> <div class="panel-panel panel-col-last"> <div class="inside"><div class="panel-pane pane-highwire-markup" > <h2 class="pane-title">About the Cover</h2> <div class="pane-content"> <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" id="content-block" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div><span class="highwire-journal-article-marker-start"></span><div class="caption cover-img"><p id="p-1">Shown is a cortical neuron with CD2AP tagged with green fluorescent protein to show its expression. Fluorescence was color-coded from blue (at its brightest) to yellow (dimmer) to highlight where CD2AP is expressed in dendritic spines. Loss of function variants of the CD2AP gene may contribute to late-onset Alzheimer's disease. The technique used in this image helped uncover whether loss of CD2AP function contributes to synaptic dysfunction, which is one of the causal mechanisms for late-onset Alzheimer's disease. See <a href="https://doi.org/10.1523/JNEUROSCI.1734-23.2024">Farzaneh S. Mirfakhar et al.</a> for more information on how a variant of this gene contributes to synapse dysfunction. Cover image: Cláudia Almeida and Farzaneh Mirfakhar.</p></div><span class="highwire-journal-article-marker-end"></span></div><span id="related-urls"></span></div></div> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="top-right-wrapper grid-10 omega"> <div class="panel-panel panel-region-top-right panel-region-sidebar-right"> <div class="inside"><div class="panel-pane pane-snippet pane-home-page-editors-corner pane-style-alt-content" > <div class="pane-content"> <div class="snippet home-page-editors-corner" id="home-page-editors-corner"> <div class="snippet-content"> <div id="update_container"> <div style="padding-left:14px; padding-right:8px; padding-bottom:8px"> <h2 class="rtecenter"><strong>New in the Journal</strong></h2> <p>Read the&nbsp;<a href="https://www.jneurosci.org/content/featured-research#most_discussed">most-discussed</a> articles in October.</p> <p><a href="https://www.jneurosci.org/podcast"><svg height="2px" width="100%"> <line 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