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Vaccine maker Bavarian Nordic talks mpox manufacturing expansion
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class="ArticleBase-LargeTitle">Bavarian Nordic talks mpox manufacturing expansion</span></noscript><span class="ArticleBase-DefaultTitle" data-testid="article-default-title">Bavarian Nordic talks mpox manufacturing expansion</span></h1><p class="ArticleBase-HeaderSummary" data-testid="article-summary">“We are in dialogue with the various stakeholders on what demand could look like,” says Bavarian Nordic as it contemplates further mpox vaccine capacity inhouse and through tech transfers.</p></div></div></div><div class="TwoColumnLayout-Content"><div class="TwoColumnLayout-Body"><div class="ArticleBase-Body" data-testid="article-base-body"><div class="ArticleBase-Contributors" data-testid="article-base-contributors"><div class="Contributors Contributors_variant_normal Contributors_hasAvatar" data-component="contributors"><div class="Contributors-AvatarWrapper"><a class="Contributors-AvatarLink" aria-label="Josh Abbott" data-discover="true" href="/author/josh-abbott"><img 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href="/cdn-cgi/l/email-protection#7a45090f18101f190e47381b0c1b08131b145a3415081e13195a0e1b1611095a170a15025a171b140f1c1b190e0f0813141d5a1f020a1b14091315145c1b170a4118151e0347335f484a0e12150f1d120e5f484a0e121f5f484a1c151616150d13141d5f484a1c0815175f484a3813152a0815191f09095f484a33140e1f08141b0e1315141b165f484a17131d120e5f484a13140e1f081f090e5f484a03150f545f4a3e5f4a3b5f4a3e5f4a3b5f484a381b0c1b08131b145f484a3415081e13195f484a0e1b1611095f484a170a15025f484a171b140f1c1b190e0f0813141d5f484a1f020a1b14091315145f4a3e5f4a3b120e0e0a095f493b5f483c5f483c0d0d0d541813150a0815191f090913140e16541915175f483c1c1b191316130e131f0957191b0a1b19130e035f483c181b0c1b08131b14571415081e1319570e1b16110957170a150257171b140f1c1b190e0f0813141d571f020a1b1409131514"><span class="SocialShare-IconWrapper SocialShare-IconWrapper_variant_button"><span data-component="icon" data-name="Email" class="SocialShare-Icon SocialShare-Icon_variant_button SocialShare-Icon_type_email" style="mask-image:url(/build/_assets/Email-47H7P533.svg);-webkit-mask-image:url(/build/_assets/Email-47H7P533.svg);mask-repeat:no-repeat;-webkit-mask-repeat:no-repeat;-webkit-mask-position:center;-webkit-mask-size:contain"></span></span></a></div></div><div class="ArticleBase-BodyContent ArticleBase-BodyContent_Article" data-testid="article-base-body-content"><div data-module="content" class="ContentModule-Wrapper"><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Mpox vaccine-maker Bavarian Nordic held a conference call to discuss its earnings through the third quarter of 2024 along with its manufacturing plans in Africa for next year and beyond.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">The company says that it is maximizing its manufacturing capacity in the short- and medium-term so that it can send at least 10 million doses of its modified vaccinia Ankara-Bavarian Nordic (MVA-BN) for mpox to Africa by the end of 2025.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">“We continue to manufacture at the full scale and are looking to potentially increase our capacity as we do anticipate more orders in the coming months and going into next year,” said Paul Chaplin, president and CEO of Bavarian Nordic </span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><a class="ContentText-BodyTextChunk ContentText-BodyTextChunk_link" target="_blank" href="https://seekingalpha.com/article/4737847-bavarian-nordic-s-bvnkf-q3-2024-earnings-call-transcript">during the conference call</a></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">. He noted that Africa CDC has asked for up to 15 million doses of the vaccine by the end of next year.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">An intensified </span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><a class="ContentText-BodyTextChunk ContentText-BodyTextChunk_link" target="_blank" href="https://www.bioprocessintl.com/deal-making/bavarian-nordic-to-send-500-000-doses-of-mpox-vaccine-to-africa">global collaboration</a></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"> between Bavarian Nordic and organizations such as Africa Centres for Disease Control and Prevention (CDC), World Health Organization (WHO), and Gavi the Vaccine Alliance, has pledged almost 3 million doses of to the continent through agreements and donations.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">“To ensure the continued equitable access of our vaccine, we are also looking at expanding that capacity by also discussing the tech transfer of the fill-finish of our vaccine into Africa,” Chaplin said.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">But he said performing a technology transfer to a manufacturing facility in Africa is no sure thing. “We need to see what the demand forecast will really be in the coming years to justify the costs of expanding our manufacturing into Africa.”</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">He added that Bavarian Nordic had identified several companies capable of performing manufacturing, but the company was still meeting with stakeholders to clarify future demand and justify the potentially costly tech transfer.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">The Coalition for Epidemic Preparedness Innovations (CEPI) is helping to fund three clinical trials in Africa, which are respectively seeking to improve access for priority populations, expand regulatory approval for children, and assess safety and immunogenicity in pregnant and breastfeeding women, and infants under 2 years old.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><span class="ContentText-BodyTextChunk ContentText-BodyTextChunk_bold">The financial picture</span></span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Bavarian Nordic earned about $514 million in revenue through nine months in 2024, with earnings before interest, taxes, depreciation, and amortization (EMITBA) at $98 million, down from about $220 million last year. Nevertheless, the company touted a strong showing from its Travel Health division, which grew by 21% compared with the last year. Additionally, the company has secured over $340 million in 2025 revenue from mpox/smallpox vaccine orders, including previously deferred revenue.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">The company also is also preparing to launch a vaccine for chikungunya in the first half of 2025. Chikungunya is a </span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><a class="ContentText-BodyTextChunk ContentText-BodyTextChunk_link" target="_blank" href="https://www.cdc.gov/chikungunya/about/index.html">viral disease</a></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"> spread by infected mosquitos that can result in joint and muscle pain, swelling, and rash.</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">Chaplin </span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text"><a class="ContentText-BodyTextChunk ContentText-BodyTextChunk_link" target="_blank" href="https://www.bavarian-nordic.com/media/media/news.aspx?news=7018">said</a></span><span class="ContentText ContentText_variant_bodyNormal" data-testid="content-text">, “The committed orders for next year, combined with improved performance in our Travel Health business, and the launch of our chikungunya vaccine in Europe and the US have set us up for another exciting and eventful year in 2025 in line with our vision to expand our reach and impact through life-changing solutions.”</span></p><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"></p></div></div><div class="SocialShare"><div data-component="social-share" class="SocialShare SocialShare_variant_button ArticleBase-SocialShare ArticleBase-SocialShare_second"><a target="_blank" rel="noreferrer" aria-label="Linkedin" href="https://www.linkedin.com/sharing/share-offsite/?url=https://www.bioprocessintl.com/facilities-capacity/bavarian-nordic-talks-mpox-manufacturing-expansion"><span class="SocialShare-IconWrapper SocialShare-IconWrapper_variant_button"><span data-component="icon" data-name="Linkedin" class="SocialShare-Icon SocialShare-Icon_variant_button 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class="ContributorSummary-Content ContributorSummary-Content_variant_author" data-testid="contributor-summary-content"><p class="ContentParagraph ContentParagraph_align_left" data-testid="content-paragraph"><span class="ContentText ContentText_variant_bodyNoneStyle" data-testid="content-text">Josh moved to </span><span class="ContentText ContentText_variant_bodyNoneStyle" data-testid="content-text"><span class="ContentText-BodyTextChunk ContentText-BodyTextChunk_italic">BioProcess Insider </span></span><span class="ContentText ContentText_variant_bodyNoneStyle" data-testid="content-text">in July 2024 after joining the Informa team in 2022 as an editor for </span><span class="ContentText ContentText_variant_bodyNoneStyle" data-testid="content-text"><span class="ContentText-BodyTextChunk ContentText-BodyTextChunk_italic">BioProcess International</span></span><span class="ContentText ContentText_variant_bodyNoneStyle" data-testid="content-text">. He received his degree in journalism from the University of Oregon and is therefore obligated to say "Go Ducks," even though he kind of feels sorry for the state rival Beavers and wishes they would win more than once a decade.</span></p></div></div></div><div class="ContributorSummary-SeeMore"><a data-component="button" class="Button Button_size_medium Button_variant_textLink" rel="" data-discover="true" href="/author/josh-abbott"><span class="Button-ContentWrapper"><span class="ContributorSummary-SeeMoreText"><span>See more from <!-- -->Josh Abbott</span><span data-component="icon" data-name="ChevronRight" class="ContributorSummary-SeeMoreIcon" style="mask-image:url(/build/_assets/ChevronRight-NHDKEYGJ.svg);-webkit-mask-image:url(/build/_assets/ChevronRight-NHDKEYGJ.svg);mask-repeat:no-repeat;-webkit-mask-repeat:no-repeat;-webkit-mask-position:center;-webkit-mask-size:contain"></span></span></span></a></div></div></div></div><p class="IirisRecommendation-Title">You May Also 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He received his degree in journalism from the University of Oregon and is therefore obligated to say \"Go Ducks,\" even though he kind of feels sorry for the state rival Beavers and wishes they would win more than once a decade."}]}]}],"gatedWithExternalForm":false,"gatedWithSiteReg":false,"paidGating":false,"sponsorName":""},"template":{"breadcrumbs":[{"url":"/","title":"Home"},{"url":"/bioprocess-insider/facilities-capacity","title":"Facilities \u0026 Capacity"}],"topics":[{"__typename":"TopicSecondary","title":"Facilities \u0026 Capacity","url":"/bioprocess-insider/facilities-capacity","parentTopic":{"title":"Bioprocess Insider"}}],"subBrand":null,"searchParams":{},"summary":"“We are in dialogue with the various stakeholders on what demand could look like,” says Bavarian Nordic as it contemplates further mpox vaccine capacity inhouse and through tech transfers. ","title":"Bavarian Nordic talks mpox manufacturing expansion","mobileHeadline":"Bavarian Nordic talks mpox manufacturing expansion","authoredBy":"","authoredOn":"","oldUrl":"","buyersJourney":"awareness","contributors":[{"title":"Josh Abbott","name":"Josh Abbott","companyName":"","role":"Editor, BioProcess Insider","avatar":"https://eu-images.contentstack.com/v3/assets/blt0a48a1f3edca9eb0/blt29e23dbf14e04f37/671125d8ae0aeeb6c7fa3d24/head1.jpg","link":"/author/josh-abbott","tagLine":"Editor, BioProcess Insider","summary":[{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"Josh moved to "},{"type":"text","marks":[{"type":"italic"}],"text":"BioProcess Insider "},{"type":"text","text":"in July 2024 after joining the Informa team in 2022 as an editor for "},{"type":"text","marks":[{"type":"italic"}],"text":"BioProcess International"},{"type":"text","text":". He received his degree in journalism from the University of Oregon and is therefore obligated to say \"Go Ducks,\" even though he kind of feels sorry for the state rival Beavers and wishes they would win more than once a decade."}]}]}],"readTime":3,"socialShare":[{"type":"Linkedin","url":"https://www.linkedin.com/sharing/share-offsite/?url=https://www.bioprocessintl.com/facilities-capacity/bavarian-nordic-talks-mpox-manufacturing-expansion"},{"type":"Twitter","url":"http://www.twitter.com/intent/tweet?url=https://www.bioprocessintl.com/facilities-capacity/bavarian-nordic-talks-mpox-manufacturing-expansion"},{"type":"Email","url":"mailto:?subject=Bavarian Nordic talks mpox manufacturing expansion\u0026body=I%20thought%20the%20following%20from%20BioProcess%20International%20might%20interest%20you.%0D%0A%0D%0A%20Bavarian%20Nordic%20talks%20mpox%20manufacturing%20expansion%0D%0Ahttps%3A%2F%2Fwww.bioprocessintl.com%2Ffacilities-capacity%2Fbavarian-nordic-talks-mpox-manufacturing-expansion"}],"publishedDate":"2024-11-19T22:39:19.000Z","keywords":[],"atAGlance":[],"bodyJson":[{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"Mpox vaccine-maker Bavarian Nordic held a conference call to discuss its earnings through the third quarter of 2024 along with its manufacturing plans in Africa for next year and beyond."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"The company says that it is maximizing its manufacturing capacity in the short- and medium-term so that it can send at least 10 million doses of its modified vaccinia Ankara-Bavarian Nordic (MVA-BN) for mpox to Africa by the end of 2025."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"“We continue to manufacture at the full scale and are looking to potentially increase our capacity as we do anticipate more orders in the coming months and going into next year,” said Paul Chaplin, president and CEO of Bavarian Nordic "},{"type":"text","marks":[{"type":"link","attrs":{"href":"https://seekingalpha.com/article/4737847-bavarian-nordic-s-bvnkf-q3-2024-earnings-call-transcript","target":"_blank","rel":null,"class":null}}],"text":"during the conference call"},{"type":"text","text":". He noted that Africa CDC has asked for up to 15 million doses of the vaccine by the end of next year."}]},{"type":"ad","pos":"300_1v_article"},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"An intensified "},{"type":"text","marks":[{"type":"link","attrs":{"href":"https://www.bioprocessintl.com/deal-making/bavarian-nordic-to-send-500-000-doses-of-mpox-vaccine-to-africa","target":"_blank","rel":null,"class":null}}],"text":"global collaboration"},{"type":"text","text":" between Bavarian Nordic and organizations such as Africa Centres for Disease Control and Prevention (CDC), World Health Organization (WHO), and Gavi the Vaccine Alliance, has pledged almost 3 million doses of to the continent through agreements and donations."}]},{"type":"ad","pos":"native_1v"},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"“To ensure the continued equitable access of our vaccine, we are also looking at expanding that capacity by also discussing the tech transfer of the fill-finish of our vaccine into Africa,” Chaplin said."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"But he said performing a technology transfer to a manufacturing facility in Africa is no sure thing. “We need to see what the demand forecast will really be in the coming years to justify the costs of expanding our manufacturing into Africa.”"}]},{"type":"ad","pos":"video_v"},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"He added that Bavarian Nordic had identified several companies capable of performing manufacturing, but the company was still meeting with stakeholders to clarify future demand and justify the potentially costly tech transfer."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"The Coalition for Epidemic Preparedness Innovations (CEPI) is helping to fund three clinical trials in Africa, which are respectively seeking to improve access for priority populations, expand regulatory approval for children, and assess safety and immunogenicity in pregnant and breastfeeding women, and infants under 2 years old."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","marks":[{"type":"bold"}],"text":"The financial picture"}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"Bavarian Nordic earned about $514 million in revenue through nine months in 2024, with earnings before interest, taxes, depreciation, and amortization (EMITBA) at $98 million, down from about $220 million last year. Nevertheless, the company touted a strong showing from its Travel Health division, which grew by 21% compared with the last year. Additionally, the company has secured over $340 million in 2025 revenue from mpox/smallpox vaccine orders, including previously deferred revenue."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"The company also is also preparing to launch a vaccine for chikungunya in the first half of 2025. Chikungunya is a "},{"type":"text","marks":[{"type":"link","attrs":{"href":"https://www.cdc.gov/chikungunya/about/index.html","target":"_blank","rel":null,"class":null}}],"text":"viral disease"},{"type":"text","text":" spread by infected mosquitos that can result in joint and muscle pain, swelling, and rash."}]},{"type":"paragraph","attrs":{"textAlign":"left"},"content":[{"type":"text","text":"Chaplin "},{"type":"text","marks":[{"type":"link","attrs":{"href":"https://www.bavarian-nordic.com/media/media/news.aspx?news=7018","target":"_blank","rel":null,"class":null}}],"text":"said"},{"type":"text","text":", “The committed orders for next year, combined with improved performance in our Travel Health business, and the launch of our chikungunya vaccine in Europe and the US have set us up for another exciting and eventful year in 2025 in line with our vision to expand our reach and impact through life-changing 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