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data-event-name="pinnable-header.vector-toc.unpin">nascondi</button> </div> <ul class="vector-toc-contents" id="mw-panel-toc-list"> <li id="toc-mw-content-text" class="vector-toc-list-item vector-toc-level-1"> <a href="#" class="vector-toc-link"> <div class="vector-toc-text">Inizio</div> </a> </li> <li id="toc-Farmacodinamica" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmacodinamica"> <div class="vector-toc-text"> <span class="vector-toc-numb">1</span> <span>Farmacodinamica</span> </div> </a> <ul id="toc-Farmacodinamica-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Farmacocinetica" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Farmacocinetica"> <div class="vector-toc-text"> <span class="vector-toc-numb">2</span> <span>Farmacocinetica</span> </div> </a> <ul id="toc-Farmacocinetica-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Usi_clinici" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Usi_clinici"> <div class="vector-toc-text"> <span class="vector-toc-numb">3</span> <span>Usi clinici</span> </div> </a> <ul id="toc-Usi_clinici-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Controindicazioni" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Controindicazioni"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Controindicazioni</span> </div> </a> <ul id="toc-Controindicazioni-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Uso_e_Vie_di_Somministrazione" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Uso_e_Vie_di_Somministrazione"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Uso e Vie di Somministrazione</span> </div> </a> <ul id="toc-Uso_e_Vie_di_Somministrazione-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Note" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Note"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Note</span> </div> </a> <ul id="toc-Note-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Bibliografia" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Bibliografia"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Bibliografia</span> </div> </a> <ul id="toc-Bibliografia-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Altri_progetti" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Altri_progetti"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Altri progetti</span> </div> </a> <ul id="toc-Altri_progetti-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Indice" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Mostra/Nascondi l'indice" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Mostra/Nascondi l'indice</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Lornoxicam</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Vai a una voce in un'altra lingua. Disponibile in 16 lingue" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-16" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">16 lingue</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%84%D9%88%D8%B1%D9%86%D9%88%D9%83%D8%B3%D9%8A%D9%83%D8%A7%D9%85" title="لورنوكسيكام - arabo" lang="ar" hreflang="ar" data-title="لورنوكسيكام" data-language-autonym="العربية" data-language-local-name="arabo" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/Lornoksikam" title="Lornoksikam - bosniaco" lang="bs" hreflang="bs" data-title="Lornoksikam" data-language-autonym="Bosanski" data-language-local-name="bosniaco" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Lornoxicam" title="Lornoxicam - tedesco" lang="de" hreflang="de" data-title="Lornoxicam" data-language-autonym="Deutsch" data-language-local-name="tedesco" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%9B%CE%BF%CF%81%CE%BD%CE%BF%CE%BE%CE%B9%CE%BA%CE%AC%CE%BC%CE%B7" title="Λορνοξικάμη - greco" lang="el" hreflang="el" data-title="Λορνοξικάμη" data-language-autonym="Ελληνικά" data-language-local-name="greco" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-en mw-list-item"><a href="https://en.wikipedia.org/wiki/Lornoxicam" title="Lornoxicam - inglese" lang="en" hreflang="en" data-title="Lornoxicam" data-language-autonym="English" data-language-local-name="inglese" class="interlanguage-link-target"><span>English</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D9%84%D9%88%D8%B1%D9%86%D9%88%DA%A9%D8%B3%DB%8C%DA%A9%D8%A7%D9%85" title="لورنوکسیکام - persiano" lang="fa" hreflang="fa" data-title="لورنوکسیکام" data-language-autonym="فارسی" data-language-local-name="persiano" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%9C%D7%95%D7%A8%D7%A0%D7%95%D7%A7%D7%A1%D7%99%D7%A7%D7%90%D7%9D" title="לורנוקסיקאם - ebraico" lang="he" hreflang="he" data-title="לורנוקסיקאם" data-language-autonym="עברית" data-language-local-name="ebraico" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%83%AD%E3%83%AB%E3%83%8E%E3%82%AD%E3%82%B7%E3%82%AB%E3%83%A0" title="ロルノキシカム - giapponese" lang="ja" hreflang="ja" data-title="ロルノキシカム" data-language-autonym="日本語" data-language-local-name="giapponese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Lornoxicam" title="Lornoxicam - portoghese" lang="pt" hreflang="pt" data-title="Lornoxicam" data-language-autonym="Português" data-language-local-name="portoghese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Lornoxicam" title="Lornoxicam - rumeno" lang="ro" hreflang="ro" data-title="Lornoxicam" data-language-autonym="Română" data-language-local-name="rumeno" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%9B%D0%BE%D1%80%D0%BD%D0%BE%D0%BA%D1%81%D0%B8%D0%BA%D0%B0%D0%BC" title="Лорноксикам - russo" lang="ru" hreflang="ru" data-title="Лорноксикам" data-language-autonym="Русский" data-language-local-name="russo" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Lornoksikam" title="Lornoksikam - serbo-croato" lang="sh" hreflang="sh" data-title="Lornoksikam" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="serbo-croato" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Lornoksikam" title="Lornoksikam - serbo" lang="sr" hreflang="sr" data-title="Lornoksikam" data-language-autonym="Српски / srpski" data-language-local-name="serbo" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sv mw-list-item"><a href="https://sv.wikipedia.org/wiki/Lornoxikam" title="Lornoxikam - svedese" lang="sv" hreflang="sv" data-title="Lornoxikam" data-language-autonym="Svenska" data-language-local-name="svedese" class="interlanguage-link-target"><span>Svenska</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%9B%D0%BE%D1%80%D0%BD%D0%BE%D0%BA%D1%81%D0%B8%D0%BA%D0%B0%D0%BC" title="Лорноксикам - ucraino" lang="uk" hreflang="uk" data-title="Лорноксикам" data-language-autonym="Українська" data-language-local-name="ucraino" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Lornoxicam" title="Lornoxicam - vietnamita" lang="vi" hreflang="vi" data-title="Lornoxicam" data-language-autonym="Tiếng Việt" data-language-local-name="vietnamita" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q2734874#sitelinks-wikipedia" title="Modifica collegamenti interlinguistici" class="wbc-editpage">Modifica collegamenti</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespace"> <div id="p-associated-pages" class="vector-menu vector-menu-tabs mw-portlet mw-portlet-associated-pages" > <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="ca-nstab-main" class="selected vector-tab-noicon mw-list-item"><a href="/wiki/Lornoxicam" title="Vedi la voce [c]" accesskey="c"><span>Voce</span></a></li><li id="ca-talk" class="vector-tab-noicon mw-list-item"><a href="/wiki/Discussione:Lornoxicam" rel="discussion" title="Vedi le discussioni relative a questa pagina [t]" accesskey="t"><span>Discussione</span></a></li> </ul> </div> </div> <div id="vector-variants-dropdown" class="vector-dropdown emptyPortlet" > <input type="checkbox" id="vector-variants-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-variants-dropdown" class="vector-dropdown-checkbox " aria-label="Cambia versione linguistica" > <label id="vector-variants-dropdown-label" for="vector-variants-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">italiano</span> </label> <div class="vector-dropdown-content"> <div id="p-variants" class="vector-menu mw-portlet mw-portlet-variants emptyPortlet" > <div class="vector-menu-content"> <ul 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questa pagina [h]" accesskey="h"><span>Cronologia</span></a></li> </ul> </div> </div> </nav> <nav class="vector-page-tools-landmark" aria-label="Strumenti pagine"> <div id="vector-page-tools-dropdown" class="vector-dropdown vector-page-tools-dropdown" > <input type="checkbox" id="vector-page-tools-dropdown-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-tools-dropdown" class="vector-dropdown-checkbox " aria-label="Strumenti" > <label id="vector-page-tools-dropdown-label" for="vector-page-tools-dropdown-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet" aria-hidden="true" ><span class="vector-dropdown-label-text">Strumenti</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-tools-unpinned-container" class="vector-unpinned-container"> <div id="vector-page-tools" class="vector-page-tools vector-pinnable-element"> <div class="vector-pinnable-header 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href="/wiki/Speciale:PuntanoQui/Lornoxicam" title="Elenco di tutte le pagine che sono collegate a questa [j]" accesskey="j"><span>Puntano qui</span></a></li><li id="t-recentchangeslinked" class="mw-list-item"><a href="/wiki/Speciale:ModificheCorrelate/Lornoxicam" rel="nofollow" title="Elenco delle ultime modifiche alle pagine collegate a questa [k]" accesskey="k"><span>Modifiche correlate</span></a></li><li id="t-specialpages" class="mw-list-item"><a href="/wiki/Speciale:PagineSpeciali" title="Elenco di tutte le pagine speciali [q]" accesskey="q"><span>Pagine speciali</span></a></li><li id="t-permalink" class="mw-list-item"><a href="/w/index.php?title=Lornoxicam&oldid=140384377" title="Collegamento permanente a questa versione di questa pagina"><span>Link permanente</span></a></li><li id="t-info" class="mw-list-item"><a href="/w/index.php?title=Lornoxicam&action=info" title="Ulteriori informazioni su questa pagina"><span>Informazioni pagina</span></a></li><li id="t-cite" class="mw-list-item"><a href="/w/index.php?title=Speciale:Cita&page=Lornoxicam&id=140384377&wpFormIdentifier=titleform" title="Informazioni su come citare questa pagina"><span>Cita questa voce</span></a></li><li id="t-urlshortener" class="mw-list-item"><a href="/w/index.php?title=Speciale:UrlShortener&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FLornoxicam"><span>Ottieni URL breve</span></a></li><li id="t-urlshortener-qrcode" class="mw-list-item"><a href="/w/index.php?title=Speciale:QrCode&url=https%3A%2F%2Fit.wikipedia.org%2Fwiki%2FLornoxicam"><span>Scarica codice QR</span></a></li> </ul> </div> </div> <div id="p-coll-print_export" class="vector-menu mw-portlet mw-portlet-coll-print_export" > <div class="vector-menu-heading"> Stampa/esporta </div> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li id="coll-create_a_book" class="mw-list-item"><a href="/w/index.php?title=Speciale:Libro&bookcmd=book_creator&referer=Lornoxicam"><span>Crea un 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I contenuti hanno solo fine illustrativo e non sostituiscono il parere medico: <a href="/wiki/Wikipedia:Disclaimer_medico" title="Wikipedia:Disclaimer medico">leggi le avvertenze</a>.</span></div> </div> <table class="infobox sinottico" summary="Tabella sinottica che riassume i principali dati del soggetto" style="width:300px;"><tbody><tr class="sinottico_testata"><th colspan="2" style="background-color:#AADDFF;">Lornoxicam</th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><figure class="mw-halign-center" typeof="mw:File/Frameless"><a href="/wiki/File:Lornoxicam_skeletal.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Lornoxicam_skeletal.svg/260px-Lornoxicam_skeletal.svg.png" decoding="async" width="260" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Lornoxicam_skeletal.svg/390px-Lornoxicam_skeletal.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/ae/Lornoxicam_skeletal.svg/520px-Lornoxicam_skeletal.svg.png 2x" data-file-width="584" data-file-height="303" /></a><figcaption></figcaption></figure> </td></tr><tr><td class="sinottico_testo_centrale" colspan="2"><figure class="mw-halign-center" typeof="mw:File/Frameless"><a href="/wiki/File:Lornoxicam_ball-and-stick.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Lornoxicam_ball-and-stick.png/260px-Lornoxicam_ball-and-stick.png" decoding="async" width="260" height="184" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Lornoxicam_ball-and-stick.png/390px-Lornoxicam_ball-and-stick.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/9c/Lornoxicam_ball-and-stick.png/520px-Lornoxicam_ball-and-stick.png 2x" data-file-width="2000" data-file-height="1418" /></a><figcaption></figcaption></figure> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF;">Nome <a href="/wiki/Unione_internazionale_di_chimica_pura_e_applicata" title="Unione internazionale di chimica pura e applicata">IUPAC</a></th></tr><tr><td class="sinottico_testo_centrale" colspan="2">1,1-diossido di 6-cloro-4-idrossi-2-metil-<i>N</i>-2-piridil-2<i>H</i>-tieno[2,3-e][1,2]-tiazin-3-carbossammide </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF;">Nomi alternativi</th></tr><tr><td class="sinottico_testo_centrale" colspan="2">CTX; Chlorotenoxicam; Chlortenoxicam; Lornoksikaami; Lornoxicam; Lornoxicanum; </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Caratteristiche generali</th></tr><tr><th><a href="/wiki/Formula_bruta" title="Formula bruta">Formula bruta</a> o <a href="/wiki/Formula_molecolare" title="Formula molecolare">molecolare</a></th><td>C<sub>13</sub>H<sub>10</sub>ClN<sub>3</sub>O<sub>4</sub>S<sub>2</sub> </td></tr><tr><th><a href="/wiki/Massa_molecolare" title="Massa molecolare">Massa molecolare</a> (<a href="/wiki/Unit%C3%A0_di_massa_atomica" title="Unità di massa atomica">u</a>)</th><td>371.8 g/mol </td></tr><tr><th><a href="/wiki/Numero_CAS" title="Numero CAS">Numero CAS</a></th><td><span class="reflink plainlinksneverexpand"><span class="noarchive"><a class="external text" href="https://iw.toolforge.org/magnustools/cas.php?language=it&cas=70374-39-9">70374-39-9</a></span></span> </td></tr><tr><th><a href="/wiki/Numero_EINECS" title="Numero EINECS">Numero EINECS</a></th><td>630-354-7 </td></tr><tr><th><a href="/wiki/Sistema_di_classificazione_anatomico,_terapeutico_e_chimico" title="Sistema di classificazione anatomico, terapeutico e chimico">Codice ATC</a></th><td><a href="/wiki/Codice_ATC_M01" title="Codice ATC M01">M01</a><span class="reflink plainlinksneverexpand"><a rel="nofollow" class="external text" href="http://www.whocc.no/atc_ddd_index/?code=M01AC05">AC05</a></span> </td></tr><tr><th><a href="/wiki/PubChem" title="PubChem">PubChem</a></th><td><a rel="nofollow" class="external text" href="http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5282204">5282204</a> </td></tr><tr><th><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td><a rel="nofollow" class="external text" href="http://www.drugbank.ca/drugs/DBDB06725">DBDB06725</a> </td></tr><tr><th><a href="/wiki/SMILES" title="SMILES">SMILES</a></th><td><div style="word-break: break-all;"><code style="background-color:transparent; border:none">CN1C(=C(C2=C(S1(=O)=O)C=C(S2)Cl)O)C(=O)NC3=CC=CC=N3</code></div> </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Dati farmacocinetici</th></tr><tr><th><a href="/wiki/Biodisponibilit%C3%A0" title="Biodisponibilità">Biodisponibilità</a></th><td>% </td></tr><tr><th><a href="/wiki/Legame_dei_farmaci_alle_proteine_plasmatiche" title="Legame dei farmaci alle proteine plasmatiche">Legame proteico</a></th><td>99 % </td></tr><tr><th><a href="/wiki/Metabolismo" title="Metabolismo">Metabolismo</a></th><td>epatico (<a href="/wiki/Citocromo_P450" title="Citocromo P450">CYP</a>2C9) </td></tr><tr><th><a href="/wiki/Emivita_(farmacologia)" title="Emivita (farmacologia)">Emivita</a></th><td>3-4 ore<sup id="cite_ref-pmid9646006_1-0" class="reference"><a href="#cite_note-pmid9646006-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </td></tr><tr><th><a href="/wiki/Escrezione" title="Escrezione">Escrezione</a></th><td><a href="/wiki/Fegato" title="Fegato">epatica</a> 50%, <a href="/wiki/Renale" class="mw-redirect" title="Renale">renale</a> 42% </td></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#AAEEFF;">Indicazioni di sicurezza</th></tr><tr class="sinottico_divisione"><th colspan="2" style="background-color:#DDEEFF; font-weight:normal;"><a href="/wiki/Simboli_di_rischio_chimico" title="Simboli di rischio chimico">Simboli di rischio chimico</a></th></tr><tr><td class="sinottico_testo_centrale" colspan="2"><span typeof="mw:File"><a href="/wiki/File:GHS-pictogram-skull.svg" class="mw-file-description" title="tossicità acuta"><img alt="tossicità acuta" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/50px-GHS-pictogram-skull.svg.png" decoding="async" width="50" height="50" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/75px-GHS-pictogram-skull.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/58/GHS-pictogram-skull.svg/100px-GHS-pictogram-skull.svg.png 2x" data-file-width="724" data-file-height="724" /></a></span>  </td></tr><tr><td class="sinottico_testo_centrale" colspan="2">pericolo </td></tr><tr><th><a href="/wiki/Frasi_H" class="mw-redirect" title="Frasi H">Frasi H</a></th><td><abbr title="Letale se ingerito.">300 </abbr> </td></tr><tr><th><a href="/wiki/Consigli_P" title="Consigli P">Consigli P</a></th><td><abbr title="Lavare accuratamente dopo l'uso.">264 </abbr>- <abbr title="In caso di ingestione: contattare immediatamente un centro antiveleni o un medico.">301+310 </abbr><sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup> </td></tr><tr><td class="sinottico_piede2 noprint nomobile metadata" colspan="2"><a href="https://www.wikidata.org/wiki/Q2734874" class="extiw" title="d:Q2734874"><span title="Modifica i dati della voce Lornoxicam su Wikidata">Modifica dati su Wikidata</span></a><b> ·</b> <a href="/wiki/Template:Composto_chimico/man" title="Template:Composto chimico/man"><span title="Manuale del template Composto chimico">Manuale</span></a></td></tr></tbody></table> <p>Il <b>Lornoxicam</b> è un farmaco antinfiammatorio non steroideo <a href="/wiki/FANS" title="FANS">FANS</a>, che rientra nella classe degli oxicam ed è dotato di importanti proprietà analgesiche. </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Farmacodinamica">Farmacodinamica</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=1" title="Modifica la sezione Farmacodinamica" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=1" title="Edit section's source code: Farmacodinamica"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il farmaco determina un blocco della sintesi delle prostaglandine inibendo la ciclossigenasi. Inibisce inoltre la liberazione dei radicali liberi dell'ossigeno dai leucociti attivati. </p> <div class="mw-heading mw-heading2"><h2 id="Farmacocinetica">Farmacocinetica</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=2" title="Modifica la sezione Farmacocinetica" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=2" title="Edit section's source code: Farmacocinetica"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Dopo somministrazione orale lornoxicam viene assorbito in modo quasi completo dal tratto gastrointestinale. Il farmaco si distribuisce rapidamente ai ari tessuti biologici. La <a href="/wiki/Concentrazione_plasmatica" title="Concentrazione plasmatica">concentrazione plasmatica</a> massima viene raggiunte entro 2 ore dall'assunzione. La <a href="/wiki/Biodisponibilit%C3%A0" title="Biodisponibilità">biodisponibilità</a> assoluta è nell'ordine del 90–100%. L'emivita plasmatica media è di circa 3–5 ore.<sup id="cite_ref-pmid9646006_1-1" class="reference"><a href="#cite_note-pmid9646006-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> Il legame con le proteine plasmatiche, particolarmente con l'albumina, è del 99%. Il principale metabolita è il 5'-idrossi-lornoxicam, sprovvisto di attività farmacologica. Il farmaco viene eliminato per via (35% circa) e per via epatica (65% circa). Nelle urine è possibile ritrovare solo il metabolita 5'-idrossi-lornoxicam.<sup id="cite_ref-pmid2284217_3-0" class="reference"><a href="#cite_note-pmid2284217-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid2284218_4-0" class="reference"><a href="#cite_note-pmid2284218-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid15127622_5-0" class="reference"><a href="#cite_note-pmid15127622-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Usi_clinici">Usi clinici</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=3" title="Modifica la sezione Usi clinici" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=3" title="Edit section's source code: Usi clinici"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Il farmaco viene utilizzato nel dolore moderato e grave, in particolare nel trattamento sintomatico del dolore e della flogosi in soggetti con affezioni reumatiche infiammatorie (ad esempio artrite reumatoide<sup id="cite_ref-pmid12087911_6-0" class="reference"><a href="#cite_note-pmid12087911-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> o spondilitite anchilosante) o degenerative.<sup id="cite_ref-pmid2284220_7-0" class="reference"><a href="#cite_note-pmid2284220-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Controindicazioni">Controindicazioni</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=4" title="Modifica la sezione Controindicazioni" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=4" title="Edit section's source code: Controindicazioni"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Controindicato nel caso di ipersensibilità al lornoxicam o ad uno degli eccipienti, nel terzo trimestre di <a href="/wiki/Gravidanza" title="Gravidanza">gravidanza</a> e non dovrebbe essere assunto durante il primo e secondo trimestre della gravidanza, scompenso cardiaco, <a href="/wiki/Insufficienza_epatica" title="Insufficienza epatica">insufficienza epatica</a> e renale. </p> <div class="mw-heading mw-heading2"><h2 id="Uso_e_Vie_di_Somministrazione">Uso e Vie di Somministrazione</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=5" title="Modifica la sezione Uso e Vie di Somministrazione" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=5" title="Edit section's source code: Uso e Vie di Somministrazione"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Nel trattamento dell'osteoartrosi e dell'artrite reumatoide<sup id="cite_ref-Frizziero_8-0" class="reference"><a href="#cite_note-Frizziero-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> il lornoxicam è assunto per OS con una dose giornaliera di 12 mg in due o tre dosi divise. </p><p>Lornoxicam è somministrato in dosi da 8 a 16 mg al dì per via orale per il trattamento del <a href="/wiki/Dolore" title="Dolore">dolore</a>. Dosi superiori a 8 mg devono essere somministrate in dosi divise. Le stesse dosi possono essere assunte con iniezione endovenosa o intramuscolare; anche se in rari casi, la massima dose giornaliera iniziale può essere aumentata a 24 mg. Il trattamento tramite per via parenterale dovrebbe essere limitato a soli 2 giorni. </p> <div class="mw-heading mw-heading2"><h2 id="Note">Note</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=6" title="Modifica la sezione Note" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=6" title="Edit section's source code: Note"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-references-wrap"><ol class="references"> <li id="cite_note-pmid9646006-1"><span class="mw-cite-backlink"><b>^</b> <sup><i><a href="#cite_ref-pmid9646006_1-0">a</a></i></sup> <sup><i><a href="#cite_ref-pmid9646006_1-1">b</a></i></sup></span> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> NM. Skjodt, NM. Davies, <span style="font-style:italic;">Clinical pharmacokinetics of lornoxicam. A short half-life oxicam.</span>, in <span style="font-style:italic;">Clin Pharmacokinet</span>, vol. 34, n. 6, Jun 1998, pp. 421-8, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/9646006?dopt=Abstract">PMID 9646006</a>.</cite></span> </li> <li id="cite_note-2"><a href="#cite_ref-2"><b>^</b></a> <span class="reference-text">Sigma Aldrich; rev. del 10.12.2012</span> </li> <li id="cite_note-pmid2284217-3"><a href="#cite_ref-pmid2284217_3-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> G. Hitzenberger, S. Radhofer-Welte; F. Takacs; D. Rosenow, <span style="font-style:italic;">Pharmacokinetics of lornoxicam in man.</span>, in <span style="font-style:italic;">Postgrad Med J</span>, 66 Suppl 4, 1990, pp. S22-7, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/2284217?dopt=Abstract">PMID 2284217</a>.</cite></span> </li> <li id="cite_note-pmid2284218-4"><a href="#cite_ref-pmid2284218_4-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> P. Turner, A. Johnston, <span style="font-style:italic;">Clinical pharmacokinetic studies with lornoxicam.</span>, in <span style="font-style:italic;">Postgrad Med J</span>, 66 Suppl 4, 1990, pp. S28-9, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/2284218?dopt=Abstract">PMID 2284218</a>.</cite></span> </li> <li id="cite_note-pmid15127622-5"><a href="#cite_ref-pmid15127622_5-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> YL. Zeng, XY. Chen; YF. Zhang; DF. Zhong, <span style="font-style:italic;">[Determination of lornoxicam in human plasma by LC/MS/MS].</span>, in <span style="font-style:italic;">Yao Xue Xue Bao</span>, vol. 39, n. 2, Feb 2004, pp. 132-5, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/15127622?dopt=Abstract">PMID 15127622</a>.</cite></span> </li> <li id="cite_note-pmid12087911-6"><a href="#cite_ref-pmid12087911_6-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> VV. Tsurko, EIa. Parnes; MIa. Krasnosel'skiĭ, <span style="font-style:italic;">[Clinical efficacy of xefocam and its effect on arterial pressure and heart rhythm variability in patients with rheumatoid arthritis in combination with arterial hypertension].</span>, in <span style="font-style:italic;">Ter Arkh</span>, vol. 74, n. 5, 2002, pp. 63-6, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/12087911?dopt=Abstract">PMID 12087911</a>.</cite></span> </li> <li id="cite_note-pmid2284220-7"><a href="#cite_ref-pmid2284220_7-0"><b>^</b></a> <span class="reference-text"><cite class="citation pubblicazione" style="font-style:normal"> H. Berry, S. Ollier, <span style="font-style:italic;">Lornoxicam in clinical practice.</span>, in <span style="font-style:italic;">Postgrad Med J</span>, 66 Suppl 4, 1990, pp. S41-5, <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/2284220?dopt=Abstract">PMID 2284220</a>.</cite></span> </li> <li id="cite_note-Frizziero-8"><a href="#cite_ref-Frizziero_8-0"><b>^</b></a> <span class="reference-text">Frizziero L, et al. Studio a lungo termine su efficacia e sicurezza terapeutica di lornoxicam nell'artrite reumatoide. Minerva Med 2002; 93: 315–20. <a class="external mw-magiclink-pmid" rel="nofollow" href="//www.ncbi.nlm.nih.gov/pubmed/12207202?dopt=Abstract">PMID 12207202</a></span> </li> </ol></div> <div class="mw-heading mw-heading2"><h2 id="Bibliografia">Bibliografia</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=7" title="Modifica la sezione Bibliografia" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=7" title="Edit section's source code: Bibliografia"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li>Riassunto Caratteristiche del Prodotto - Data di Revisione del Testo - Dete. AIFA del 5 dicembre 2007.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Altri_progetti">Altri progetti</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Lornoxicam&veaction=edit&section=8" title="Modifica la sezione Altri progetti" class="mw-editsection-visualeditor"><span>modifica</span></a><span class="mw-editsection-divider"> | </span><a href="/w/index.php?title=Lornoxicam&action=edit&section=8" title="Edit section's source code: Altri progetti"><span>modifica wikitesto</span></a><span class="mw-editsection-bracket">]</span></span></div> <div id="interProject" class="toccolours" style="display: none; clear: both; margin-top: 2em"><p id="sisterProjects" style="background-color: #efefef; color: black; font-weight: bold; margin: 0"><span>Altri progetti</span></p><ul title="Collegamenti verso gli altri progetti Wikimedia"> <li class="" title=""><span class="plainlinks" title="commons:Category:Lornoxicam"><a class="external 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class="navbox_list navbox_odd"><a href="/wiki/Auranofin" title="Auranofin">Auranofin</a><b> ·</b> <a href="/wiki/Aurotioprolo" title="Aurotioprolo">Aurotioprolo</a><b> ·</b> <a href="/w/index.php?title=Sodio_aurotiomalato&action=edit&redlink=1" class="new" title="Sodio aurotiomalato (la pagina non esiste)">Sodio aurotiomalato</a><b> ·</b> <a href="/w/index.php?title=Aurotiosolfato_di_sodio&action=edit&redlink=1" class="new" title="Aurotiosolfato di sodio (la pagina non esiste)">Aurotiosolfato di sodio</a><b> ·</b> <a href="/w/index.php?title=Tioglicolato_di_oro_e_sodio&action=edit&redlink=1" class="new" title="Tioglicolato di oro e sodio (la pagina non esiste)">Tioglicolato di oro e sodio</a><b> ·</b> <a href="/w/index.php?title=Tiomalato_di_oro_e_sodio&action=edit&redlink=1" class="new" title="Tiomalato di oro e sodio (la pagina non esiste)">Tiomalato di oro e sodio</a><b> ·</b> <a href="/w/index.php?title=Aurotiopropanolo&action=edit&redlink=1" class="new" title="Aurotiopropanolo (la pagina non esiste)">Aurotiopropanolo</a></td></tr><tr><th colspan="1" class="navbox_group">Aminochinoline</th><td colspan="1" class="navbox_list navbox_even"><a href="/wiki/Clorochina" title="Clorochina">Clorochina</a><b> ·</b> <a href="/wiki/Idrossiclorochina" title="Idrossiclorochina">Idrossiclorochina</a><b> ·</b> <a href="/wiki/Amodiachina" title="Amodiachina">Amodiachina</a><b> ·</b> <a href="/w/index.php?title=Propachina&action=edit&redlink=1" class="new" title="Propachina (la pagina non esiste)">Propachina</a></td></tr><tr><th colspan="1" class="navbox_group">Antigottosi</th><td colspan="1" class="navbox_list navbox_odd"><a href="/wiki/Colchicina" title="Colchicina">Colchicina</a></td></tr><tr><th colspan="1" class="navbox_group">Derivati dell'acido nicotinico</th><td colspan="1" class="navbox_list navbox_even"><a href="/wiki/Clonixina" title="Clonixina">Clonixina</a><b> ·</b> <a href="/wiki/Isonixina" title="Isonixina">Isonixina</a></td></tr><tr><th colspan="1" class="navbox_group">Altri</th><td colspan="1" class="navbox_list navbox_odd"><a href="/wiki/Dimetilsolfossido" title="Dimetilsolfossido">Dimetilsolfossido</a><b> ·</b> <a href="/wiki/Penicillamina" title="Penicillamina">Penicillamina</a><b> ·</b> <a href="/w/index.php?title=Levamisol&action=edit&redlink=1" class="new" title="Levamisol (la pagina non esiste)">Levamisol</a><b> ·</b> <a href="/w/index.php?title=Viminol&action=edit&redlink=1" class="new" title="Viminol (la pagina non esiste)">Viminol</a><b> ·</b> <a href="/wiki/Bumadizone" title="Bumadizone">Bumadizone</a><b> ·</b> <a href="/w/index.php?title=Proquazone&action=edit&redlink=1" class="new" title="Proquazone (la pagina non esiste)">Proquazone</a><b> ·</b> <a href="/wiki/Salazosulfapiridina" title="Salazosulfapiridina">Salazosulfapiridina</a></td></tr><tr><td colspan="2" class="navbox_list navbox_center navbox_even">I farmaci indicati <b>grassetto</b> sono i precursori di ciascun gruppo. <sup>†</sup>Farmaci ritirati dal commercio. <sup>‡</sup>Farmaci a uso veterinario.</td></tr></tbody></table> <div class="noprint" style="width:100%; padding: 3px 0; display: flex; flex-wrap: wrap; row-gap: 4px; column-gap: 8px; box-sizing: border-box;"><div style="flex-basis: calc( 100% / 2 - 8px / 2 );"><style data-mw-deduplicate="TemplateStyles:r140555418">.mw-parser-output .itwiki-template-occhiello{width:100%;line-height:25px;border:1px solid #CCF;background-color:#F0EEFF;box-sizing:border-box}.mw-parser-output .itwiki-template-occhiello-progetto{background-color:#FAFAFA}@media screen{html.skin-theme-clientpref-night .mw-parser-output .itwiki-template-occhiello{background-color:#202122;border-color:#54595D}html.skin-theme-clientpref-night .mw-parser-output .itwiki-template-occhiello-progetto{background-color:#282929}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .itwiki-template-occhiello{background-color:#202122;border-color:#54595D}html.skin-theme-clientpref-os 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