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Upon activation, FIX is converted into the active serine protease and, in the presence of Ca 2+ and membrane phospholipids, it hydrolyses one arginine-isoleucine bond in factor X to form the activated factor X (Xa) [1].</div></div> <a id="human-coagulation-factor-ix" class="namePlace ps1"></a><div class="container m1 p16 bg17 fnt9 inform0"><div class="cont9 bx2 w1 ds2 ps2"> <div class="w15 ds3 vr2 bx2 " id="human-coagulation-factor-ix"><div class="styk top"><h2 class="clr13 fnt7 fnt17 bo1 videoclass"> Human Coagulation Factor IX</h2><div class="ds2 m26"> <div class="bdr15 bg1 ps2 ds3 vr2"> <span id="pvdo1" class="playV cu_p" onclick="_gaq.push(['b._trackEvent','Body','prod-video','d0055']);recEvent('Body','prod-video','d0055');getindex(1);playVideo('');" style="display:none"></span><span id ="pimg1"></span> <div class="ds3 cen4 vr1 txt3 cu_p prd_cntr" onclick="page_name('productpage','count2','index_1');imgset_zoom(1,'dataref');_gaq.push(['b._trackEvent','Body','ProductImage/1/category','d0055']);recEvent('Body','ProductImage/1/category','d0055');attachClickEvent(1,'img_form','count2');"> <img class="max-width" alt="Human Coagulation Factor IX" id="1" src="data:image/gif;base64,R0lGODlhAQABAAAAACwAAAAAAQABAAA=" dataimg="https://5.imimg.com/data5/ANDROID/Default/2024/8/440011584/HC/RV/KG/6127097/product-jpeg-500x500.jpeg" data-bimg="https://5.imimg.com/data5/ANDROID/Default/2024/8/440011584/HC/RV/KG/6127097/product-jpeg-500x500.jpeg" data-multiimg="https://5.imimg.com/data5/ANDROID/Default/2024/8/440011584/HC/RV/KG/6127097/product-jpeg-500x500.jpeg,https://5.imimg.com/data5/ANDROID/Default/2024/8/440012623/XR/NM/AN/6127097/product-jpeg-1000x1000.jpeg,https://5.imimg.com/data5/ANDROID/Default/2024/8/440012805/GQ/KP/QB/6127097/product-jpeg-1000x1000.jpeg,https://5.imimg.com/data5/ANDROID/Default/2024/8/440012822/VR/MI/CV/6127097/product-jpeg-1000x1000.jpg,https://5.imimg.com/data5/ANDROID/Default/2024/8/440012823/RK/HK/RC/6127097/product-jpeg-1000x1000.jpg" data-vdocode="" name="index_1"><noscript><img src="https://5.imimg.com/data5/ANDROID/Default/2024/8/440011584/HC/RV/KG/6127097/product-jpeg-250x250.jpeg" alt="Human Coagulation Factor IX"> </noscript> </div> <div id="zoom1" class="ps1 zm cp" onclick="page_name('productpage','count2','index_1'); 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Price: <span class="fnt18 clr16">Rs 6,950</span><span class="fnt21 clr19"> / Bottle</span><span class="glp_gp fnt12 cu_p" onclick="page_name('productpage','count_glp','index_1'); imgset_zoom(1,'dataref');attachClickEvent(1,'non_img','count_glp');_gaq.push(['b._trackEvent','Body','GetLatestPrice/1/category','d0055']);recEvent('Body','GetLatestPrice/1/category','d0055');">Get Latest Price</span></span><div class="cl"></div><div class="lin"></div><div class="sp arrow m38"></div><div class="he06 m4" id="prdcont1"> <p><b>Product Details:</b></p><div class="cl"></div><div class="fram isq"><table><tr class="ds6"><td class="ds3 w12_mn">Minimum Order Quantity</td><td class="ds3 w15_mn">10 Bottle</td></tr><tr><td>Form</td><td>Injection</td></tr><tr><td>Type</td><td>Injection</td></tr><tr><td>Usage/Application</td><td>Hospital</td></tr><tr><td>Prescription/Non prescription</td><td>Prescription</td></tr><tr><td>Composition</td><td>Human Coagulation Factor IX</td></tr><tr><td>Country of Origin</td><td>Made in India</td></tr></table></div><br><p dir="ltr"><br> Hematology disorders such as those caused by key plasma protein deficiencies that impede blood clotting or, conversely, result in excessive clotting, can result in serious medical complications or even death. Leveraging our experience in plasma-based clotting factors, Grifols is focused on widening our indication reach to help a larger number of patients living with these disorders.</p> <p dir="ltr"><span style="font-size:1.40em;"><b>Fostamatinib for chronic immune thrombocytopenia (ITP)</b></span></p> <p dir="ltr">In people with ITP, the immune system attacks and destroys the body's own blood platelets, cells which play an active role in blood clotting and healing. Fostamatinib is the first new treatment for people with ITP in decades. It prevents the pathologic destruction of platelets by inhibiting a signaling cascade mediated by spleen tyrosine kinase (SYK).</p> <p dir="ltr">Learn more about our approved fostamatinib treatment for ITP <a href="https://www.grifols.com/web/gcom/view-news/-/news/grifols-starts-commercializing-tavlesse-in-europe-diversifying-its-medicines-portfolio">here</a>. </p> <p dir="ltr"><span style="font-size:1.40em;"><b>A fibrinogen concentrate for bleeding management</b></span></p> <p dir="ltr">Fibrinogen is a blood plasma protein made in the liver that is involved in coagulation and wound healing. When the concentration of this protein in a person’s plasma falls below a critical level or when it does not function properly, the ability to stop the bleeding is compromised.</p> <p dir="ltr">Our Biotest group is investigating the use of a fibrinogen concentrate, purified fibrinogen with a precisely defined amount of fibrinogen, as a therapy to treat major bleeding linked to acquired fibrinogen deficiency, such as during surgical procedures. Biotest is also evaluating this fibrinogen concentrate for congenital fibrinogen deficiency, a very rare inherited condition affecting the production or function of this protein.</p> <p dir="ltr"><span style="font-size:1.40em;"><b>Antithrombin III (AT-III) and intensive care</b></span></p> <p dir="ltr">Grifols continues advancing in AT-III to ensure the right coagulation balance for patients, and is investigating the potential of this protein in a clinical trial to treat a life-threatening coagulopathy that results from sepsis. In the U.S., roughly 60% of sepsis cases become severe,<sup>1</sup> with 30 to 50%<sup>2</sup> of these severe sepsis patients experiencing disseminated intravascular coagulopathy (DIC). DIC involves excessive clotting in the bloodstream that can lead to massive bleeding elsewhere in the body and can lead to multiorgan failure. </p> <p dir="ltr">Antithrombin limits the blood’s ability to clot by inhibiting thrombin, an enzyme that presides over the conversion of a substance called fibrinogen to fibrin, which promotes blood clotting. Its balance in plasma is key to avoiding too much clotting or bleeding issues.  Our AT-III is the only plasma-derived medicine authorized and approved by the U.S. Food and Drug Administration to treat AT-III deficiency, an inherited blood-clotting disorder. </p><div class="ds ps1 rcb bg19 bx4 cu_p " onclick="page_name('productpage','count_callback','index_1'); imgset_zoom('1','dataref');attachClickEvent(1,'non_img','count_callback'); _gaq.push(['b._trackEvent','Body','RCB/1/category','d0055']);recEvent('Body','RCB/1/category','d0055') " title="Get a Call from us"><div class="clr3 fnt6 fnt17 bo1"> Request<br><strong>Callback</strong></div></div><div class="bg18 ps1"></div> </div> <div class="cl m8 p30 bo1"><span class="bg19 fl bdr8 fnt17 clr3 fnt7 p18 bdr16 btn7 cu_p" onclick="page_name('productpage','count_intrstd' ,'index_1');imgset_zoom('1','dataref');_gaq.push(['b._trackEvent','Body','IMInterested/1/category','d0055']);recEvent('Body','IMInterested/1/category','d0055');attachClickEvent(1,'non_img','count_intrstd');">Yes! 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