NeoTYPE® Discovery Profile for Solid Tumors

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<div class="assay-print-wrap"> <a href="/print/view/pdf/assay_print/page_1?view_args[]=383" class="print-btn small-upper">Print</a> </div> </div></span></div></div> </div> </div> </div> </div> <div id="block-testmenufavoritetest" class="my-favorite-tests block block-block-content block-block-contentc2aaa209-cb1f-4176-a902-c9dd36e703e2"> <h4>My Favorite Tests</h4> <div class="default-message"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>Please select your favorite tests to print a custom catalog. 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width="961"> </div> </article> <p><a style="height:100%;left:0;position:absolute;top:0;width:100%;" href="https://neogenomics.wistia.com/medias/96g0e6jvzm" target="_blank"> </a></p> </div> </div> </div> </div> </aside> <section class="sidebar-left content-wrap"> <div class="layout-content"> <a id="main-content" tabindex="-1"></a> <div class="region region-content"> <div data-drupal-messages-fallback class="hidden"></div> <div id="block-neogenomics-content" class="block block-system block-system-main-block"> <article data-history-node-id="383" class="node node--type-assay node--view-mode-full"> <div class="node__content"> <div class="field field--name-field-alternative-name field--type-string field--label-above"> <div class="field__label">Alternative Name</div> <div class="field__item">Discovery Profile</div> </div> <div class="field field--name-field-methodology field--type-entity-reference field--label-above"> <div class="field__label">Methodology</div> <div class="field__items"> <div class="field__item">Molecular</div> </div> </div> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-above"> <div class="field__label">Test Description</div> <div class="field__item"><p>The NeoTYPE Discovery Profile analyzes 336 biomarkers through a combination of next-generation sequencing (NGS), FISH, and IHC as listed below. Test orders include summary interpretation of all results to help guide treatment decisions. For non-breast tumors, HER2 (Other) w/ Breast Scoring will be added. For breast tumors, HER2 Breast IHC/FISH can be ordered separately, if clinically indicated. If global HER2 (Other) IHC w/Breast Scoring result is 2+, case will reflex to global HER2 (Other) FISH w/Breast Scoring unless reflex to tech-only FISH or reflex opt-out is requested. If Pan-TRK IHC is expressed or equivocal, reflex to either NTRK NGS Fusion Panel (Default) or NTRK 1-3 FISH Panel will be added. A microsatellite instability (MSI) NGS result of “indeterminate” will create a reflex to MSI by PCR as long as the tumor percentage is ≥20% for colorectal specimens or ≥40% with paired normal tissue available for non-colorectal specimens.</p> <ul> <li>FISH (8 FISH): ALK, BRAF, MET, MYC, PDGFRA amplifications, PTEN, RET, ROS1 (tech-only available)</li> <li>IHC (3 biomarkers): HER2 (Other) w/Breast Scoring (non-breast tumors only), PD-L1 22C3 (breast, lung) or PD-L1 LDT (other), Pan-TRK (tech-only available for HER2 and PD-L1)</li> <li>NGS (323 genes + 2 biomarkers): ABL1, ABL2, ACVR1B, ADGRA2 (GPR124), AKT1, AKT2, AKT3, ALK, AMER1, APC, AR, ARAF, ARFRP1, ARID1A, ARID1B, ARID2, ASXL1, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, BAP1, BARD1, BCL2, BCL2L1, BCL2L2, BCL6, BCOR, BCORL1, BLM, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTK, CARD11, CBFB, CBL, CCND1, CCND2, CCND3, CCN6 (WISP3), CCNE1, CD274, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CHD4, CHEK1, CHEK2, CIC, CREBBP, CRKL, CRLF2, CSF1R, CTCF, CTNNA1, CTNNB1, CUL3, CXCR4, CYLD, DAXX, DDR2, DICER1, DNMT3A, DOT1L, EGFR, EMSY (C11orf30), EP300, EPCAM, EPHA3, EPHA5, EPHA7, EPHB1, ERBB2, ERBB3, ERBB4, ERG, ERRFI1, ESR1, EZH2, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FAS, FAT1, FBXW7, FGF10, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT1, FLT3, FLT4, FOXL2, FOXP1, FRS2, FUBP1, GABRA6, GATA1, GATA2, GATA3, GATA4, GATA6, GID4, GLI1, GNA11, GNA13, GNAQ, GNAS, GRIN2A, GRM3, GSK3B, HGF, HNF1A, HRAS, HSD3B1, HSP90AA1, H3-3A (H3F3A), H3C3 (HIST1H3C), IDH1, IDH2, IGF1R, IGF2, IKBKE, IKZF1, IL7R, INHBA, INPP4B, IRF2, IRF4, IRS2, JAK1, JAK2, JAK3, JUN, KAT6A, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIT, KLHL6, KMT2A, KMT2C, KMT2D, KRAS (includes G12C mutation), LMO1, LRP1B, LYN, LZTR1, MAGI2, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MCL1, MDM2, MDM4, MED12, MEF2B, MEN1, MET, Microsatellite Instability (MSI), MITF, MLH1, MPL, MRE11 (MRE11A), MSH2, MSH6, MTOR, MUTYH, MYC, MYCL, MYCN, MYD88, NBN, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NSD1, NTRK1, NTRK2, NTRK3, NUP93, PAK3, PALB2, PAX5, PBRM1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PIK3C2B, PIK3CA, PIK3CB, PIK3CG, PIK3R1, PIK3R2, PLCG2, PMS2, POLD1, POLE, PPP2R1A, PRDM1, PREX2, PRKAR1A, PRKCI, PRKDC, PRKN (PARK2), PRSS8, PTCH1, PTEN, PTPN11, QKI, RAC1, RAD50, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, RAF1, RANBP2, RARA, RB1, RBM10, RET, RICTOR, RNF43, ROS1, RPTOR, RUNX1, RUNX1T1, SDHA, SDHB, SDHC, SDHD, SETD2, SF3B1, SLIT2, SMAD2, SMAD3, SMAD4, SMARCA4, SMARCB1, SMO, SNCAIP, SOCS1, SOX10, SOX2, SOX9, SPEN, SPOP, SPTA1, SRC, STAG2, STAT3, STAT4, STK11, SUFU, SYK, TAF1, TBX3, TENT5C (FAM46C), TERC, TERT promoter, TET2, TGFBR2, TNFAIP3, TNFRSF14, TOP1, TOP2A, TP53, TSC1, TSC2, TSHR, U2AF1, VEGFA, VHL, WT1, XPO1, ZBTB2, ZNF217, ZNF703, Tumor Mutation Burden (TMB)</li> </ul> </div> </div> <div class="clearfix text-formatted field field--name-field-clinical-significance field--type-text-long field--label-above"> <div class="field__label">Clinical Significance</div> <div class="field__item"><p>The NeoTYPE Discovery Profile for Solid Tumors combines NGS, FISH and IHC to allow for the accurate and sensitive detection of genomic alterations in the genes most relevant to various solid tumor cancers. These genomic alterations include SNP's, indels, rearrangements and other alterations. Testing can aid in the diagnosis of various diseases and provide information to develop strategies for the treatment and management of the underlying disease. In addition, the results obtained from the NeoTYPE Discovery Profile for Solid Tumors can also be used in current or future clinical research projects.</p> </div> </div> <div class="clearfix text-formatted field field--name-field-specimen-requirements-old field--type-text-long field--label-above"> <div class="field__label">Specimen Requirements</div> <div class="field__item"><ul> <li><strong>FFPE tissue:</strong> Paraffin block preferred. Please use 10% buffered formalin fixative. Do not use zinc fixatives.</li> </ul> </div> </div> <div class="clearfix text-formatted field field--name-field-storage-transportation-old field--type-text-long field--label-above"> <div class="field__label">Storage & Transportation</div> <div class="field__item"><p>Use cold pack for transport, making sure cold pack is not in direct contact with specimen. All slides can be packed at room temperature.</p> </div> </div> <div class="field field--name-field-cpt-code-s-old field--type-string field--label-above"> <div class="field__label">CPT Code(s)*</div> <div class="field__item">81455x1, 88377x8; 88360x2, 88342x1; add 88374x1 if HER2 IHC is reflexed to FISH; add 81479x1 if reflexed to NTRK NGS Fusion Panel (default) or 88374x3 automated (88377x3 manual) if reflexed to NTRK 1-3 FISH Panel</div> </div> <div class="field field--name-field-moldx-cpt-code-s-old field--type-string field--label-above"> <div class="field__label">Medicare MolDX CPT Code(s)*</div> <div class="field__item">81479</div> </div> <div class="clearfix text-formatted field field--name-field-turnaround-time field--type-text-long field--label-above"> <div class="field__label">Turnaround Time</div> <div class="field__item"><p>14 days; add 1-3 days if reflexed to NTRK NGS Fusion Profile</p> </div> </div> <div class="field field--name-field-level-of-service field--type-entity-reference field--label-above"> <div class="field__label">Level of Service</div> <div class="field__items"> <div class="field__item">Global</div> </div> </div> <div class="field field--name-field-new-york-approved field--type-boolean field--label-above"> <div class="field__label">New York Approved</div> <div class="field__item">Yes</div> </div> </div> </article> </div> <div id="block-cptdisclaimer" class="block block-block-content block-block-content781357ea-908d-4604-8c0b-058bcf2b6f64"> <div class="clearfix text-formatted field field--name-body field--type-text-with-summary field--label-hidden field__item"><p>*The CPT codes provided with our test descriptions are based on AMA guidelines and are for informational purposes only. 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class="form-autocomplete form-text" data-autocomplete-path="/search_api_autocomplete/site_search?display=page_1&&filter=search" type="text" id="edit-search" name="search" value="" size="30" maxlength="128" /> </div> <div data-drupal-selector="edit-actions" class="form-actions js-form-wrapper form-wrapper" id="edit-actions--4"><input data-drupal-selector="edit-submit-site-search" type="submit" id="edit-submit-site-search" value="Search" class="button js-form-submit form-submit" /> </div> </div> </form> </div> <nav role="navigation" aria-labelledby="block-footerutility-menu" id="block-footerutility" class="block block-menu navigation menu--footer-utility"> <h2 class="visually-hidden" id="block-footerutility-menu">Footer Utility</h2> <ul class="menu nav menu-level-0"> <li class="client-services menu__item"> <a href="/client-services" class="client-services menu__link" data-drupal-link-system-path="node/9">Client Services</a> </li> <li class="about menu__item"> <a href="/about" 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href="/diagnostic-services/specialty-testing/neo-comprehensive-solid-tumor" class="neo-comprehensive---solid-tumor menu__link" data-drupal-link-system-path="node/1618">Neo Comprehensive - Solid Tumor</a> </li> <li class="compass® menu__item"> <a href="/diagnostic-services/specialty-testing/compassr" class="compass® menu__link" data-drupal-link-system-path="node/1069">COMPASS®</a> </li> <li class="cancertype-id® menu__item"> <a href="/diagnostic-services/specialty-testing/cancertype-idr" class="cancertype-id® menu__link" data-drupal-link-system-path="node/1070">CancerTYPE ID®</a> </li> <li class="hereditary-cancer menu__item"> <a href="/diagnostic-services/specialty-testing/hereditary-cancer" class="hereditary-cancer menu__link" data-drupal-link-system-path="node/1073">Hereditary Cancer</a> </li> <li class="invisionfirst®-lung-liquid-biopsy menu__item"> <a href="/invisionfirstr-lung" class="invisionfirst®-lung-liquid-biopsy menu__link" data-drupal-link-system-path="node/1155">InVisionFirst®-Lung Liquid Biopsy</a> </li> <li class="liquid-biopsy menu__item"> <a href="/diagnostic-services/specialty-testing/liquid-biopsy" class="liquid-biopsy menu__link" data-drupal-link-system-path="node/1072">Liquid Biopsy</a> </li> <li class="neotype® menu__item"> <a href="/diagnostic-services/specialty-testing/neotyper-cancer-profiles" class="neotype® menu__link" data-drupal-link-system-path="node/1156">NeoTYPE®</a> </li> <li class="early-stage-nsclc-panel menu__item"> <a href="/diagnostic-services/specialty-testing/early-stage-nsclc-panel" class="early-stage-nsclc-panel menu__link" data-drupal-link-system-path="node/1708">Early-Stage NSCLC Panel</a> </li> </ul> </div> </li> </ul> </div> </li> <li class="dropdown-item pharma-services menu__item"> <a href="/pharma-services" class="dropdown-item pharma-services menu__item dropdown-toggle menu__link" data-drupal-link-system-path="node/5">Pharma Services</a> <span class="far 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class="testing-terminology menu__link" data-drupal-link-system-path="node/1139">Testing Terminology</a> </li> <li class="testing-methods-and-tumor-profiling menu__item"> <a href="/patients/testing-methods-and-tumor-profiling" class="testing-methods-and-tumor-profiling menu__link" data-drupal-link-system-path="node/1140">Testing Methods and Tumor Profiling</a> </li> <li class="sponsored-testing-programs-for-patients menu__item"> <a href="/patients/sponsored-testing-programs-patients" class="sponsored-testing-programs-for-patients menu__link" data-drupal-link-system-path="node/1255">Sponsored Testing Programs for Patients</a> </li> <li class="frequently-asked-questions menu__item"> <a href="/patients/frequently-asked-questions" class="frequently-asked-questions menu__link" data-drupal-link-system-path="node/1315">Frequently Asked Questions</a> </li> <li class="invisionfirst®-lung-(liquid-biopsy) menu__item"> <a href="/patients/invisionfirstr-lung-liquid-biopsy" class="invisionfirst®-lung-(liquid-biopsy) menu__link" data-drupal-link-system-path="node/1572">InVisionFirst®-Lung (Liquid Biopsy)</a> </li> </ul> </div> </li> <li class="test-menu menu__item"> <a href="/test-menu" class="test-menu menu__link" data-drupal-link-system-path="test-menu">Test Menu</a> </li> <li class="search menu__item"> <span class="far fa-search color-green search menu__link">Search</span> </li> </ul> </nav> <nav role="navigation" aria-labelledby="block-headerutility-2-menu" id="block-headerutility-2" class="push-nav-utility-menu push-menu block block-menu navigation menu--header-utility"> <h2 class="visually-hidden" id="block-headerutility-2-menu">Header Utility</h2> <ul class="menu nav menu-level-0"> <li class="dropdown-item client-services menu__item"> <a href="/client-services" class="dropdown-item client-services menu__item dropdown-toggle menu__link" data-drupal-link-system-path="node/9">Client Services</a> <span class="far fa-angle-right nolink-toggle" 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data-zindex="1" title="About - 7530"></span> <div class="dropdown-menu-list menu-level-1"> <ul class="menu-list-1"> <li class="events menu__item"> <a href="/events" class="events menu__item dropdown-toggle menu__link">Events</a> <span class="far fa-angle-right nolink-toggle" data-toggle=".menu-level-2" tabindex="0" data-zindex="2" title="Events - 6322"></span> <div class="dropdown-menu-list menu-level-2"> <ul class="menu-list-2"> <li class="molecular-tumor-board menu__item"> <a href="/events/molecular-tumor-boards" class="molecular-tumor-board menu__link" data-drupal-link-system-path="node/1294">Molecular Tumor Board</a> </li> <li class="trade-shows menu__item"> <a href="/events/trade-shows" class="trade-shows menu__link" data-drupal-link-system-path="node/1295">Trade Shows</a> </li> <li class="webinars menu__item"> <a href="/events/webinars" class="webinars menu__link" data-drupal-link-system-path="node/1297">Webinars</a> </li> <li class="diagnostic-symposiums menu__item"> <a href="/events/diagnostic-symposiums" class="diagnostic-symposiums menu__link" data-drupal-link-system-path="node/1296">Diagnostic Symposiums</a> </li> </ul> </div> </li> <li class="newsroom menu__item"> <a href="/newsroom" class="newsroom menu__item dropdown-toggle menu__link" data-drupal-link-system-path="newsroom">Newsroom</a> <span class="far fa-angle-right nolink-toggle" data-toggle=".menu-level-2" tabindex="0" data-zindex="2" title="Newsroom - 6404"></span> <div class="dropdown-menu-list menu-level-2"> <ul class="menu-list-2"> <li class="blog menu__item"> <a href="/newsroom/blog" class="blog menu__link" data-drupal-link-system-path="newsroom/blog">Blog</a> </li> <li class="press-releases menu__item"> <a href="/newsroom/press-releases" class="press-releases menu__link" data-drupal-link-system-path="newsroom/press-releases">Press Releases</a> </li> <li class="literature menu__item"> <a href="/newsroom/literature" class="literature menu__link" data-drupal-link-system-path="newsroom/literature">Literature</a> </li> <li class="podcast menu__item"> <a href="/newsroom/podcast" class="podcast menu__link" data-drupal-link-system-path="newsroom/podcast">Podcast</a> </li> <li class="videos menu__item"> <a href="/newsroom/videos" class="videos menu__link" data-drupal-link-system-path="newsroom/videos">Videos</a> </li> </ul> </div> </li> <li class="our-team menu__item"> <a href="/about/our-team" class="our-team menu__link" data-drupal-link-system-path="node/1136">Our Team</a> </li> <li class="employee-benefits menu__item"> <a href="/about/employee-benefits" class="employee-benefits menu__link" data-drupal-link-system-path="node/1314">Employee Benefits</a> </li> <li class="investors menu__item"> <a href="https://ir.neogenomics.com" class="investors menu__link" target="_blank">Investors</a> </li> <li class="neouniversity menu__item"> <a href="/about/neouniversity" class="neouniversity menu__link" 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