Oral Solid Dose (OSD) Manufacturing & Development

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border-color: #ED7700"> <i class="fak fa-globalbrand-data icon"></i> <div class="main-text"></div> <div class="sub-text"><h4><b><span style="color: rgb(237,119,0);">60-70%</span></b></h4> <p class="p-claim">Sixty to 70% of molecules in clinical development have high permeability but poor solubility; predictive modeling can help</p> </div> </div> <div class="takeaway-card" style="color: #ED7700; border-color: #ED7700"> <i class="fak fa-globalbrand-analyze icon"></i> <div class="main-text"></div> <div class="sub-text"><h4><b><span style="color: rgb(237,119,0);">78%</span></b></h4> <p class="p-claim">We are involved with 78% of the top-performing drug products, delivering reliability and quality</p> </div> </div> <div class="takeaway-card" style="color: #ED7700; border-color: #ED7700"> <i class="fak fa-globalbrand-molecule icon"></i> <div class="main-text"></div> <div class="sub-text"><h4><b><span style="color: rgb(237,119,0);">>700</span></b></h4> <p class="p-claim">We worked on over 700 large and small molecules in 2022</p> </div> </div> <div class="takeaway-card" style="color: #ED7700; border-color: #ED7700"> <i class="fak fa-globalbrand-award icon"></i> <div class="main-text"></div> <div class="sub-text"><h4><span><span style="color: rgb(237,119,0);"><b>3 of the top 8</b></span></span></h4> <p class="p-claim">We have developed and launched 3 of the top 8 best-selling small molecule drugs<br /> </p> <p> </p> <p> </p> </div> </div> </div> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " style="background-position-x: center;background-position-y: center;" id="well-826026621"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="custom-html-cmp aem-GridColumn aem-GridColumn--default--12"> <hr> </div> </div> </div> </div> <style type="text/css"> #well-826026621 { border-radius: 0px; } </style> </div> </div> </div> </div> <style type="text/css"> #well-204116238 { border-radius: 0px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " style="background-position-x: center;background-position-y: center;" id="well-1111425370"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-435f00e56e" class="cmp-text list-style-bullets"> <h2><b>Oral solid dose formulation development services</b></h2> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-6fd47daff9" class="cmp-text list-style-bullets"> <p>Formulation development is a pivotal step in drug development, as it directly affects the safety, efficacy, pharmacokinetics, and patient compliance of a medication. This process involves creating a suitable formulation and manufacturing method to produce a finished product that meets the desired target product profile (TPP).</p> <p>A well-designed formulation ensures that the active pharmaceutical ingredient (API) is effectively delivered within the body, maximizing therapeutic impact while minimizing adverse effects. Through formulation and process development, it’s possible to achieve the desired TPP, which is essential to establishing safety and stability data during clinical evaluation and developing a viable process for commercial manufacturing.</p> <p>Read more: <a href="https://www.patheon.com/us/en/insights-resources/blog/inside-pharmaceutical-formulation-development.html">Inside drug development: The fundamental principles of pharmaceutical formulation</a></p> <p>Thermo Fisher Scientific provides comprehensive end-to-end services, from early-phase formulation development to late-phase process optimization and commercial manufacturing.</p> </div> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1965423706"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-761270248"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="early-phase-development-services" class="cmp-text list-style-bullets"> <h3 style="font-size: 24.0px;"><b>Early-phase development services</b></h3> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-a02d2ed0e2" class="cmp-text list-style-bullets"> <p>Our early-phase formulation development scientists have the breadth and depth of experience and expertise to support your needs at every step. </p> <ul> <li style="color: rgb(38,34,98);"><b>Accelerate your project to first-in-human (FIH) studies</b></li> <li style="color: rgb(38,34,98);"><b>Rapid preformulation to characterize drug substance and excipient compatibility</b></li> <li style="color: rgb(38,34,98);"><b>Rapid stability evaluation of prototype formulations using ASAP stability program</b></li> <li style="color: rgb(38,34,98);"><b>Quickly evaluate formulation options using algorithmic-based tools and our expertise</b></li> <li style="color: rgb(38,34,98);"><b>Enhanced solubility techniques to improve bioavailability</b></li> <li style="color: rgb(38,34,98);"><b>Pave the way for preclinical and clinical studies</b></li> <li style="color: rgb(38,34,98);"><b>Develop, validate, and implement analytical and process methodologies</b></li> <li style="color: rgb(38,34,98);"><b>Generate the CMC data required for IND filings</b></li> </ul> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-5a1850f3d4" class="cmp-text "> <p>In addition, as part of our end-to-end solutions, our clinical research group experts offer comprehensive clinical support to ensure a successful IND filing. For more information, please visit our <a href="https://www.ppd.com/how-we-help/integrated-cro-and-cdmo-solutions/">Integrated CRO and CDMO Solutions | PPD Inc</a>.</p> </div> </div> </div> </div> <style type="text/css"> #container-761270248{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-761270248 { border-radius: px; } </style> </div> </div> </div> <style type="text/css"> #container-1965423706{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1965423706 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1201804483"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="accordion-434736966"> <div class="accordion-item"> <div class="accordion-header" id="heading-accordion-434736966"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-accordion-434736966" aria-expanded="true" aria-controls="collapse-accordion-434736966"> <span> <span class="accordion-title">Bioavailability and solubility enhancement solutions</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-accordion-434736966" class="accordion-collapse collapse " aria-labelledby="heading-accordion-434736966" data-bs-parent="#accordion-434736966"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-049fe5b8eb" class="cmp-text list-style-bullets"> <p>The solubility of oral solid dose drugs presents an increasing threat to molecule advancement through the drug development pipeline, particularly since a majority of current new drug candidates exhibit poor solubility. Without dissolution and absorption into the bloodstream via the gastrointestinal tract, drugs cannot achieve systemic circulation to exert their intended effects. Addressing solubility is thus crucial to overcoming bioavailability hurdles.</p> <p>Thermo Fisher Scientific provides a comprehensive range of solubility enhancement solutions, including spray drying, hot melt extrusion (HME), lipid formulation, micronization, and solid state chemistry. Learn more on our <a href="https://www.patheon.com/us/en/our-capabilities/small-molecule/oral-solid-dose/bioavailability-solubility-enhancement.html">Bioavailability and solubility enhancement</a> page.</p> </div> </div> <div class="cmp-button aem-GridColumn aem-GridColumn--default--12"> <div id="button-817105004" class="btn-wrapper"> <a class=" btn btn-style-primary icon-placement-left " href="https://www.patheon.com/us/en/our-capabilities/small-molecule/oral-solid-dose/bioavailability-solubility-enhancement.html" role="button" target="_self"> Go to Bioavailability and solubility enhancement page </a> </div> <style> #button-817105004 .btn-style-quickLink { border-left: 6px solid #1E8AE7; } #button-817105004 { padding-right:0px; padding-left:0px; } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1201804483{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1201804483 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-310966632"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="accordion-1690726177"> <div class="accordion-item"> <div class="accordion-header" id="heading-accordion-1690726177"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-accordion-1690726177" aria-expanded="true" aria-controls="collapse-accordion-1690726177"> <span> <span class="accordion-title">In silico predictive modeling and simulation services</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-accordion-1690726177" class="accordion-collapse collapse " aria-labelledby="heading-accordion-1690726177" data-bs-parent="#accordion-1690726177"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-8a90457e12" class="cmp-text list-style-bullets"> <p>In silico modeling technologies are transforming drug development and manufacturing by enhancing efficiency and accuracy while fostering innovation. Powered by artificial intelligence, machine learning, bioinformatics, molecular dynamics simulations, and systems biology, these cutting-edge tools help accelerate the development of new drugs, optimize their formulations, ensure quality in manufacturing, and streamline regulatory processes, all while potentially reducing costs and time to market.</p> <p><b>Advantages of Thermo Fisher Scientific’s engineered solutions:</b></p> <ul> <li>Mitigate development risks and minimize experimental failures</li> <li>Expedite development timelines</li> <li>Reduce overall costs</li> <li>Conserve valuable API resources</li> <li>Enable informed decision-making and rational drug design</li> <li>Diminish dependency on animal testing</li> </ul> <p>To learn more about Thermo Fisher Scientific’s digital modeling services, visit our <a href="https://www.patheon.com/us/en/our-capabilities/small-molecule/oral-solid-dose/in-silico-modeling.html">in silico modeling page</a>.</p> </div> </div> <div class="cmp-button aem-GridColumn aem-GridColumn--default--12"> <div id="button-38178471" class="btn-wrapper"> <a class=" btn btn-style-primary icon-placement-left " href="https://www.patheon.com/us/en/our-capabilities/small-molecule/oral-solid-dose/in-silico-modeling.html" role="button" target="_self"> Go to in silico modeling page </a> </div> <style> #button-38178471 .btn-style-quickLink { border-left: 6px solid #1E8AE7; } #button-38178471 { padding-right:0px; padding-left:0px; } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-310966632{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-310966632 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-1609527039"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-1609527039 { border-radius: 0px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-44704597"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="late-phase-development-services" class="cmp-text list-style-bullets"> <h3 style="font-size: 24.0px;"><b>Late-phase development and commercial services</b></h3> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-a9e595883b" class="cmp-text list-style-bullets"> <p>Thermo Fisher Scientific specializes in late-phase development of OSD forms, ranging from simple immediate-release formulations to complex dosage forms such as osmotic drug delivery, modified release, high-potency compounds, DEA-controlled substances, spray drying, hot melt extrusion (HME), and bead coating. Backed by an industry-leading network, we have the global and regional resources to meet your specific needs. With over 40 years of experience in developing a wide range of OSD forms, Thermo Fisher Scientific has successfully supported the commercial launch of numerous projects for our clients. Our expert scientists excel in designing customizable solutions tailored to meet your <a href="https://www.patheon.com/us/en/our-capabilities/commercial-services.html">commercial production</a> needs.</p> <p>Our facilities are equipped with commercial packaging lines capable of packing finished products in bottles, blisters, stick packs, and sachets. With integrated laboratories and extensive network lab testing capabilities, we can develop and validate analytical methods for experimental batch testing, stability studies, clinical trial material (CTM), and commercial batch release. Our late-phase services include CTM supplies for phase II and III trials, registration support, scale-up, process validation, site transfers, and commercial manufacturing. At Thermo Fisher Scientific, we are dedicated to meeting your project timelines while upholding the highest standards of quality, delivering right-first-time, on-time results.</p> <p style="color: rgb(38,34,98);"><b>Advantages of Thermo Fisher Scientific’s services:</b></p> <ul> <li style="color: rgb(38,34,98);"><b>Strong regulatory track record</b></li> <li style="color: rgb(38,34,98);"><b>Multiple commercial launches</b></li> <li style="color: rgb(38,34,98);"><b>Expertise in scale-up and GMP manufacturing</b></li> <li style="color: rgb(38,34,98);"><b>Global capacity expansion to meet growing commercial needs</b></li> <li style="color: rgb(38,34,98);"><b>Global quality standards across all sites</b></li> <li style="color: rgb(38,34,98);"><b>Qualified personnel</b></li> <li style="color: rgb(38,34,98);"><b>Digital platforms for project and business management</b></li> <li style="color: rgb(38,34,98);"><b>Logistics management</b></li> <li style="color: rgb(38,34,98);"><b>Flexible capabilities to accommodate small-scale through large-scale projects</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-44704597{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-44704597 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-2112579869"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-2112579869 { border-radius: 0px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-1008929263"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="process-development-scale-up-and-validation" class="cmp-text list-style-bullets"> <h3 style="font-size: 24.0px;"><b>Process development, scale-up, and validation</b></h3> </div> </div> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-63ed048cff" class="cmp-text list-style-bullets"> <p>Our scale-up solutions will give you access to a risk assessment and proven acceptable range (PAR) studies, as well as validation of analytical methods and manufacturing processes. If needed, our QA and regulatory compliance team can provide data and support for the Chemistry, Manufacturing, and Controls (CMC) portion of your submission. Active pharmaceutical ingredients (API) for use in clinical trials are produced at our state-of-the-art <a href="https://www.patheon.com/us/en/site-locations.html">manufacturing facilities</a> located in Europe and North America.</p> <p>All our facilities adhere to current Good Manufacturing Practice (cGMP) regulations and undergo regular inspections by national and international regulatory agencies. A team of experts will support your discovery with a full range of technologies and analytical services to ensure flexibility and timely delivery with exceptional yields and superior quality. In late-stage trials and beyond, your drug substance will be manufactured at one of our cGMP-compliant commercial production facilities.</p> </div> </div> </div> </div> <style type="text/css"> #container-1008929263{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1008929263 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-763844574"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-763844574 { border-radius: 0px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-1614401119"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="oral-solid-dose-dosage-forms" class="cmp-text list-style-bullets"> <h2><b>Oral solid dosage forms and related profiles</b></h2> </div> </div> </div> </div> <style type="text/css"> #container-1614401119{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1614401119 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1978967641"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="tablet-manufacturing"> <div class="accordion-item"> <div class="accordion-header" id="heading-tablet-manufacturing"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-tablet-manufacturing" aria-expanded="true" aria-controls="collapse-tablet-manufacturing"> <span> <span class="accordion-title">Tablets</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-tablet-manufacturing" class="accordion-collapse collapse " aria-labelledby="heading-tablet-manufacturing" data-bs-parent="#tablet-manufacturing"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--default--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner me-lg-3 me-md-0 " id="container-705173499"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--offset--default--0 aem-GridColumn--small--6 aem-GridColumn--offset--medium--0 aem-GridColumn--medium--11 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--offset--small--0 aem-GridColumn--default--12 aem-GridColumn--xsmall--11"> <div id="text-88de25f86f" class="cmp-text list-style-bullets"> <p>Having access to both conventional and specialized dosage forms, ranging from simple to complex, enables an integrated drug formulation program tailored to the unique properties of your molecule. Collaborating closely with you, we ensure that your discoveries have a proof-of-concept designed for speed and efficiency, accelerating your molecule's progression to first-in-human (FIH) studies.</p> <p>Our formulation scientists leverage a diverse array of technologies and approaches to control the release of the active pharmaceutical ingredient (API) according to your requirements. Partnering with Thermo Fisher Scientific pharma services grants you access to a broad selection of dosage forms and release profiles, including:</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0 aem-GridColumn--medium--6"> <div class="cmp-container-inner equalizeHeights h-100" id="container-506748461"> <div class="aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--xsmall--12 "> <div class="text aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="text-2d06d5d108" class="cmp-text list-style-bullets"> <p style="color: rgb(38,34,98);"><b>Immediate release:</b></p> <ul> <li style="color: rgb(38,34,98);"><b>Dispersible tablets</b></li> <li style="color: rgb(38,34,98);"><b>Oral disintegrating tablets</b></li> <li style="color: rgb(38,34,98);"><b>Buccal tablets</b></li> <li style="color: rgb(38,34,98);"><b>Sublingual tablets</b></li> <li style="color: rgb(38,34,98);"><b>Chewable tablets</b></li> <li style="color: rgb(38,34,98);"><b>Swallowable film-coated tablets</b></li> <li style="color: rgb(38,34,98);"><b>Bilayer tablets</b></li> <li style="color: rgb(38,34,98);"><b>Trilayer tablets</b></li> <li style="color: rgb(38,34,98);"><b>Tablet in a tablet</b></li> <li style="color: rgb(38,34,98);"><b>Mini tablets</b></li> <li style="color: rgb(38,34,98);"><b>Pellets</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-506748461{ background-image: url(''); background-color: #F7F7F7; background-size: cover; background-position: center; min-height: px; } #container-506748461 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--newline aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0 aem-GridColumn--medium--6"> <div class="cmp-container-inner equalizeHeights h-100" id="container-1461251795"> <div class="aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--xsmall--6 "> <div class="text aem-GridColumn--default--none aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="text-3007e3e996" class="cmp-text list-style-bullets"> <p style="color: rgb(38,34,98);"><b>Modified release/controlled release/sustained release:</b></p> <ul> <li style="color: rgb(38,34,98);"><b>Enteric-coated tablets</b></li> <li style="color: rgb(38,34,98);"><b>Gastro-retentive tablets</b></li> <li style="color: rgb(38,34,98);"><b>Matrix tablets</b></li> <li style="color: rgb(38,34,98);"><b>Pulsatile release tablets/pellets</b></li> <li style="color: rgb(38,34,98);"><b>Multi-unit particulate system (MUPS) tablets</b></li> <li style="color: rgb(38,34,98);"><b>Osmotic tablets</b></li> <li style="color: rgb(38,34,98);"><b>Bilayer tablets (IR/MR combination)</b></li> <li style="color: rgb(38,34,98);"><b>Trilayer tablets (IR/MR combination)</b></li> <li style="color: rgb(38,34,98);"><b>Modified release coated mini tablets</b></li> <li style="color: rgb(38,34,98);"><b>Modified release pellets</b></li> <li style="color: rgb(38,34,98);"><b>Hot melt produced cut rods and tablets</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-1461251795{ background-image: url(''); 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background-position: center; min-height: px; } #container-1174233118 { border-radius: px; } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1978967641{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1978967641 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1337069260"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="capsule-manufacturing"> <div class="accordion-item"> <div class="accordion-header" id="heading-capsule-manufacturing"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-capsule-manufacturing" aria-expanded="true" aria-controls="collapse-capsule-manufacturing"> <span> <span class="accordion-title">Capsules</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-capsule-manufacturing" class="accordion-collapse collapse " aria-labelledby="heading-capsule-manufacturing" data-bs-parent="#capsule-manufacturing"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--default--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--default--12 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner me-lg-3 me-md-0 " id="container-1503381710"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--offset--default--0 aem-GridColumn--small--6 aem-GridColumn--offset--medium--0 aem-GridColumn--medium--11 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--offset--small--0 aem-GridColumn--default--12 aem-GridColumn--xsmall--11"> <div id="text-096d8ffc11" class="cmp-text list-style-bullets"> <p>Capsules are one of the most common oral dosage forms and include medication that’s enclosed in an outer shell. This outer shell is broken down in the digestive tract and the medication is absorbed into the bloodstream and then distributed and metabolized in much the same way as medication from a tablet.</p> <p>Thermo Fisher Scientific produces many different types of capsules, most popular are listed below:</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0 aem-GridColumn--medium--6"> <div class="cmp-container-inner equalizeHeights h-100" id="container-627794752"> <div class="aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--xsmall--12 "> <div class="text aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="text-a70880ff95" class="cmp-text list-style-bullets"> <p style="color: rgb(38,34,98);"><b>Capsules:</b></p> <ul> <li style="color: rgb(38,34,98);"><b>Powder/granules in capsules</b></li> <li style="color: rgb(38,34,98);"><b>Coated pellets in a capsule</b></li> <li style="color: rgb(38,34,98);"><b>Enteric release capsules</b></li> <li style="color: rgb(38,34,98);"><b>Gelatin/HPMC capsules</b></li> <li style="color: rgb(38,34,98);"><b>Liquid-filled hard capsules</b></li> <li style="color: rgb(38,34,98);"><b>Softgel capsules</b></li> <li style="color: rgb(38,34,98);"><b>Mini tablets in capsules</b></li> <li style="color: rgb(38,34,98);"><b>Tablet in a capsule (over encapsulation)</b></li> </ul> <p style="color: rgb(38,34,98);"><b>Individual dose packing:</b></p> <ul> <li style="color: rgb(38,34,98);"><b>Stick packing</b></li> <li style="color: rgb(38,34,98);"><b>Sachets </b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-627794752{ background-image: url(''); background-color: #F7F7F7; background-size: cover; background-position: center; min-height: px; } #container-627794752 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--newline aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0 aem-GridColumn--medium--6"> <div class="cmp-container-inner equalizeHeights h-100" id="container-376511054"> <div class="aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--xsmall--6 "> <div class="image aem-GridColumn--default--none aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div data-cmp-is="image" data-cmp-lazythreshold="0" data-cmp-src="/content/patheon/us/en/our-capabilities/small-molecule/oral-solid-dose/_jcr_content/root/responsivegrid/well_1934452007/container_1897428182_2144689677/accordion_1885780673/accordionparsys/container/container_copy/image.coreimg{.width}.png/1723484857857/oral-solid-dosek.png" data-asset="/content/dam/temp_patheon/library/thumbnails/oral-solid-dose/Oral_solid_doseK.png" data-asset-id="2a084e8f-b2ee-4647-8ad8-062a9abb8fed" data-title="Capsule manufacturing" id="image-1751965761" class="cmp-image false " itemscope itemtype="http://schema.org/ImageObject"> <img src="/content/patheon/us/en/our-capabilities/small-molecule/oral-solid-dose/_jcr_content/root/responsivegrid/well_1934452007/container_1897428182_2144689677/accordion_1885780673/accordionparsys/container/container_copy/image.coreimg.png/1723484857857/oral-solid-dosek.png" class="cmp-image__image false " itemprop="contentUrl" data-cmp-hook-image="image" alt="Capsule manufacturing"/> </div> </div> </div> </div> <style type="text/css"> #container-376511054{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-376511054 { border-radius: px; } </style> </div> <div class="text aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--default--12"> <div id="text-589d51ebd6" class="cmp-text list-style-bullets"> <p>In addition to these technologies, we can also fill powder in a bottle.</p> <p>Non-sterile oral liquids including solutions and suspensions can be developed and commercially manufactured at our network sites.<br /> </p> </div> </div> </div> </div> <style type="text/css"> #container-1503381710{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1503381710 { border-radius: px; } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1337069260{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1337069260 { border-radius: px; } </style> </div> <div class="cmp-well aem-GridColumn aem-GridColumn--default--12"> <div class="well " id="well-1143036078"> <div class="container-fluid container-lg "> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> </div> </div> </div> <style type="text/css"> #well-1143036078 { border-radius: 0px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-1640641231"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="oral-solid-dose-manufacturing" class="cmp-text list-style-bullets"> <h2><b>Oral solid dose (OSD) manufacturing</b></h2> </div> </div> </div> </div> <style type="text/css"> #container-1640641231{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1640641231 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1495514743"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="accordion-1825603200"> <div class="accordion-item"> <div class="accordion-header" id="heading-accordion-1825603200"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-accordion-1825603200" aria-expanded="true" aria-controls="collapse-accordion-1825603200"> <span> <span class="accordion-title">Commercial manufacturing services</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-accordion-1825603200" class="accordion-collapse collapse " aria-labelledby="heading-accordion-1825603200" data-bs-parent="#accordion-1825603200"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-571ac6b2ce" class="cmp-text list-style-bullets"> <p>At Thermo Fisher Scientific, we understand the complexities and challenges involved with bringing pharmaceutical products to market. With our comprehensive commercial manufacturing services, we offer pharmaceutical and biotechnology companies a trusted partner to navigate the journey from development to commercialization seamlessly. </p> <p>Visit our <a href="https://www.patheon.com/us/en/our-capabilities/commercial-services.html">commercial manufacturing service</a> page to learn more.</p> </div> </div> <div class="cmp-button aem-GridColumn aem-GridColumn--default--12"> <div id="button-1238377498" class="btn-wrapper"> <a class=" btn btn-style-primary icon-placement-left " href="https://www.patheon.com/us/en/our-capabilities/commercial-services.html" role="button" target="_self"> Go to commercial manufacturing services page </a> </div> <style> #button-1238377498 .btn-style-quickLink { border-left: 6px solid #1E8AE7; } #button-1238377498 { padding-right:0px; padding-left:0px; } </style> </div> </div> </div> </div> </div> </div> </div> </div> </div> <style type="text/css"> #container-1495514743{ background-image: url(''); background-color: ; background-size: cover; background-position: center; min-height: px; } #container-1495514743 { border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner py-3 " id="container-1080148355"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 "> <div class="cmp-accordion aem-GridColumn aem-GridColumn--default--12"> <div class="accordion" id="accordion-780564852"> <div class="accordion-item"> <div class="accordion-header" id="heading-accordion-780564852"> <button class="accordion-button collapsed" type="button" data-bs-toggle="collapse" data-bs-target="#collapse-accordion-780564852" aria-expanded="true" aria-controls="collapse-accordion-780564852"> <span> <span class="accordion-title">Oral solid dose manufacturing process technologies</span><br/> <span class="accordion-subtitle"></span> </span> </button> </div> <div id="collapse-accordion-780564852" class="accordion-collapse collapse " aria-labelledby="heading-accordion-780564852" data-bs-parent="#accordion-780564852"> <div class="accordion-body"> <div class="aem-Grid aem-Grid--12 aem-Grid--default--12 aem-Grid--xsmall--12 "> <div class="text aem-GridColumn aem-GridColumn--default--12"> <div id="text-ba0d25af9b" class="cmp-text list-style-bullets"> <p>Thermo Fisher Scientific has a global network of sites strategically located to meet the diverse needs of our clients, both locally and globally. To ensure successful scale-up and commercial launch, all our development equipment is aligned with commercial capabilities. We offer a broad spectrum of commercial capabilities tailored to our clients' needs, with the following technologies available for manufacturing OSD forms:</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div class="cmp-container-inner equalizeHeights h-100" id="container-1385422385"> <div class="aem-Grid aem-Grid--6 aem-Grid--default--6 aem-Grid--xsmall--12 "> <div class="text aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--default--6 aem-GridColumn--offset--default--0"> <div id="text-03b5619813" class="cmp-text list-style-bullets"> <ul> <li style="color: rgb(38,34,98);"><b>Direct blending</b></li> <li style="color: rgb(38,34,98);"><b>Wet/dry granulation</b></li> <li style="color: rgb(38,34,98);"><b>Fluid bed coating — both top and bottom spray</b></li> <li style="color: rgb(38,34,98);"><b>Hot melt extrusion (amorphous solid dispersions, pellets, cut rods, melt granulation)</b></li> <li style="color: rgb(38,34,98);"><b>Spray drying</b></li> <li style="color: rgb(38,34,98);"><b>Encapsulation</b></li> <li style="color: rgb(38,34,98);"><b>Tableting</b></li> <li style="color: rgb(38,34,98);"><b>Osmotic drug delivery</b></li> <li style="color: rgb(38,34,98);"><b>Pelletization</b></li> <li style="color: rgb(38,34,98);"><b>Sachets/stick packs</b></li> <li style="color: rgb(38,34,98);"><b>Powder in a bottle</b></li> <li style="color: rgb(38,34,98);"><b>Coating</b></li> <li style="color: rgb(38,34,98);"><b>Printing</b></li> <li style="color: rgb(38,34,98);"><b>Visual Inspection</b></li> </ul> </div> </div> </div> </div> <style type="text/css"> #container-1385422385{ background-image: url(''); 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The Bend site campus is divided into two main buildings; one devoted to business services and manufacturing, the other to warehousing, receiving, shipping, R&D and QC Laboratory services. 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Our experts at the Toronto facility are ready to address your needs for highly potent, low potent, complex formulations, pediatric dosage forms, patent-extension strategies, as well as conventional oral solid formulations.</p> </div> </div> <div class="cmp-container aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--medium--4 aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--offset--default--0 aem-GridColumn--default--4 aem-GridColumn--small--4"> <div class="cmp-container-inner py-3 " id="container-164932482"> <div class="aem-Grid aem-Grid--4 aem-Grid--default--4 aem-Grid--xsmall--6 aem-Grid--medium--4 "> <div class="cmp-button aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--medium--3 aem-GridColumn--default--none aem-GridColumn--xsmall--none aem-GridColumn aem-GridColumn--xsmall--6 aem-GridColumn--offset--default--0 aem-GridColumn--default--2"> <div 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border-radius: px; } </style> </div> <div class="cmp-container aem-GridColumn aem-GridColumn--default--12"> <div class="cmp-container-inner " id="container-1096268207"> <div class="aem-Grid aem-Grid--12 aem-Grid--small--12 aem-Grid--default--12 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="cmp-container aem-GridColumn--small--none aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--default--none aem-GridColumn--xsmall--12 aem-GridColumn--offset--default--0 aem-GridColumn--offset--medium--0 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--11 aem-GridColumn--offset--small--0 aem-GridColumn--default--6"> <div class="cmp-container-inner py-5 " id="container-603746017"> <div class="aem-Grid aem-Grid--6 aem-Grid--small--11 aem-Grid--default--6 aem-Grid--xsmall--12 aem-Grid--medium--12 "> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--11 aem-GridColumn--default--6"> <div id="text-d74014fc99" class="cmp-text list-style-bullets"> <h4><b><a href="https://www.patheon.com/us/en/site-locations/bourgoin-fr.html">Bourgoin, France</a></b></h4> <p> </p> </div> </div> <div class="text aem-GridColumn--offset--medium--0 aem-GridColumn--medium--none aem-GridColumn--offset--xsmall--0 aem-GridColumn--xsmall--12 aem-GridColumn--xsmall--none aem-GridColumn--medium--12 aem-GridColumn aem-GridColumn--small--11 aem-GridColumn--default--6"> <div id="text-7332110034" class="cmp-text list-style-bullets"> <p>Our facility in Bourgoin, France is an FDA-approved center of excellence for early- and late-stage development and commercial manufacturing for <a href="https://www.patheon.com/us/en/our-capabilities/small-molecule/oral-solid-dose.html">oral solid dose</a> (OSD) products, with a specialization in handling highly 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