Enzymes | Peer Reviewed Journals

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Enzymes are biocatalysts working as highly efficient machines at the molecular level. 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Enzymes are biocatalysts working as highly efficient machines at the molecular level. In the past, enzymes have been viewed as static entities and their function has been explained on the basis of direct structural interactions between the enzyme and the substrate. A variety of experimental and computational techniques, however, continue to reveal that proteins are dynamically active machines, with various parts exhibiting internal motions at a wide range of time-scales. Increasing evidence also indicates that these internal protein motions play a role in promoting protein function such as enzyme catalysis. Moreover, the thermodynamical fluctuations of the solvent, surrounding the protein, have an impact on internal protein motions and, therefore, on enzyme function. In this review, we describe recent biochemical and theoretical investigations of internal protein dynamics linked to enzyme catalysis. In the enzyme cyclophilin A, investigations have lead to the discovery of a network of protein vibrations promoting catalysis. Cyclophilin A catalyzes peptidyl-prolyl cis/trans isomerization in a variety of peptide and protein substrates. Recent studies of cyclophilin A are discussed in detail and other enzymes (dihydrofolate reductase and liver alcohol dehydrogenase) where similar discoveries have been reported are also briefly discussed. The detailed characterization of the discovered networks indicates that protein dynamics plays a role in rate-enhancement achieved by enzymes. An integrated view of enzyme structure, dynamics and function have wide implications in understanding allosteric and co-operative effects, as well as protein engineering of more efficient enzymes and novel drug design.</p> <p> </p> <div class="row"> <div class="col-md-6"> <h5 class="heading-bullet border-orange-800-before">High Impact List of Articles</h5> <ul class="list-group list-group-flush"> <li class="list-group-item px-0"> <a href="https://www.longdom.org/open-access/oxidative-stress-in-plants-under-drought-conditions-and-the-role-ofdifferent-enzymes-2329-6674-1000136.pdf" title="Oxidative Stress in Plants Under Drought Conditions and the Role of Different Enzymes">Oxidative Stress in Plants Under Drought Conditions and the Role of Different Enzymes</a><br/> <i class="fas fa-user"></i> Leonora Mansur Mattos, Celso Luiz Moretti <p class="mb-1"><span class="text-warning">Review Article:</span> <a href="https://www.longdom.org/enzyme-engineering.html" title="Enzyme Engineering">Enzyme Engineering</a> </p> </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/open-access/metagenomics-a-new-opportunity-for-enzyme-engineering-2329-6674-1000e112.pdf" title="Metagenomics: A New Opportunity for Enzyme Engineering">Metagenomics: A New Opportunity for Enzyme Engineering</a><br/> <i class="fas fa-user"></i> Zhenyang G, Mohamad KM and Junwen W <p class="mb-1"><span class="text-warning">Editorial:</span> <a href="https://www.longdom.org/enzyme-engineering.html" title="Enzyme Engineering">Enzyme Engineering</a> </p> </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/open-access/extraction-of-oil-from-mackerel-fish-processing-waste-using-alcalase-enzyme-2329-6674.1000115.pdf" title="Extraction of Oil from Mackerel Fish Processing Waste using Alcalase Enzyme">Extraction of Oil from Mackerel Fish Processing Waste using Alcalase Enzyme</a><br/> <i class="fas fa-user"></i> Ramakrishnan VV, Ghaly AE, Brooks MS and Budge SM <p class="mb-1"><span class="text-warning">Research Article:</span> <a href="https://www.longdom.org/enzyme-engineering.html" title="Enzyme Engineering">Enzyme Engineering</a> </p> </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/open-access/beyond-protein-engineering-its-applications-in-synthetic-biology-2329-6674.1000e103.pdf" title="Beyond Protein Engineering: its Applications in Synthetic Biology">Beyond Protein Engineering: its Applications in Synthetic Biology</a><br/> <i class="fas fa-user"></i> Yougen Li <p class="mb-1"><span class="text-warning">Editorial:</span> <a href="https://www.longdom.org/enzyme-engineering.html" title="Enzyme Engineering">Enzyme Engineering</a> </p> </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/open-access/genomic-data-mining-an-efficient-way-to-find-new-and-better-enzymes-2329-6674.1000104.pdf" title="Genomic Data Mining: An Efficient Way to Find New and Better Enzymes">Genomic Data Mining: An Efficient Way to Find New and Better Enzymes</a><br/> <i class="fas fa-user"></i> Xiao-Jing Luo, Hui-Lei Yu and Jian-He Xu <p class="mb-1"><span class="text-warning">Review Article:</span> <a href="https://www.longdom.org/enzyme-engineering.html" title="Enzyme Engineering">Enzyme Engineering</a> </p> </li> </ul> </div> <div class="col-md-6"> <h5 class="heading-bullet border-orange-800-before">Conference Proceedings</h5> <ul class="list-group list-group-flush"> <li class="list-group-item px-0"> <a href="https://www.longdom.org/proceedings/identifying-natural-synergist-from-pongamia-pinnata-using-highspeed-countercurrent-chromatography-combined-with-isobolog-56012.html" title="Identifying natural synergist from Pongamia pinnata using high-speed counter-current chromatography combined with isobolographic analysis">Identifying natural synergist from Pongamia pinnata using high-speed counter-current chromatography combined with isobolographic analysis</a> <br><i class="fas fa-user"></i> Weihong He and Hao Yin <p class="mb-1"><span class="text-warning">Posters & Accepted Abstracts:</span> <a href="https://www.longdom.org/chromatography-separation-techniques.html" title="Journal of Chromatography & Separation Techniques">Journal of Chromatography & Separation Techniques</a></p>  </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/proceedings/isoelectric-focusing-technique-as-a-tool-for-separation-of-bird-lactate-dehydrogenase-isoenzymes-55852.html" title="Isoelectric focusing technique as a tool for separation of bird lactate dehydrogenase isoenzymes">Isoelectric focusing technique as a tool for separation of bird lactate dehydrogenase isoenzymes</a> <br><i class="fas fa-user"></i> Dagmar Heinova and Zuzana Kostecka <p class="mb-1"><span class="text-warning">Scientific Tracks Abstracts:</span> <a href="https://www.longdom.org/chromatography-separation-techniques.html" title="Journal of Chromatography & Separation Techniques">Journal of Chromatography & Separation Techniques</a></p>  </li> <li class="list-group-item px-0"> <a href="https://www.longdom.org/proceedings/biosynthesis-of-the-galactomannan-in-aspergillus-fumigatus-12981.html" title="Biosynthesis of the galactomannan in Aspergillus fumigatus">Biosynthesis of the galactomannan in Aspergillus fumigatus</a> <br><i class="fas fa-user"></i> Thierry Fontaine <p class="mb-1"><span class="text-warning">Scientific Tracks Abstracts:</span> <a href="https://www.longdom.org/glycobiology.html" title="Journal of Glycobiology">Journal of Glycobiology</a></p>  </li> </ul> </div> </div>  </div> </div> </div> </section>   <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Content Links</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://www.longdom.org/online-tools.html" title="Click here">Tools</a> </li> <li><a class="" 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