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effects</span> </div> </a> <ul id="toc-Adverse_effects-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Overdose" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Overdose"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Overdose</span> </div> </a> <ul id="toc-Overdose-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacology" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Pharmacology"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Pharmacology</span> </div> </a> <button aria-controls="toc-Pharmacology-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Pharmacology subsection</span> </button> <ul id="toc-Pharmacology-sublist" class="vector-toc-list"> <li id="toc-Mechanism_of_action" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mechanism_of_action"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Mechanism of action</span> </div> </a> <ul id="toc-Mechanism_of_action-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Pharmacokinetics" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Pharmacokinetics"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Pharmacokinetics</span> </div> </a> <ul id="toc-Pharmacokinetics-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-History" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#History"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>History</span> </div> </a> <ul id="toc-History-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Society_and_culture" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Society_and_culture"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>Society and culture</span> </div> </a> <button aria-controls="toc-Society_and_culture-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Society and culture subsection</span> </button> <ul id="toc-Society_and_culture-sublist" class="vector-toc-list"> <li id="toc-Brand_names" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Brand_names"> <div class="vector-toc-text"> <span class="vector-toc-numb">8.1</span> <span>Brand names</span> </div> </a> <ul id="toc-Brand_names-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Veterinary_use" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Veterinary_use"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>Veterinary use</span> </div> </a> <ul id="toc-Veterinary_use-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav aria-label="Contents" class="vector-toc-landmark"> <div id="vector-page-titlebar-toc" class="vector-dropdown vector-page-titlebar-toc vector-button-flush-left" title="Table of Contents" > <input type="checkbox" id="vector-page-titlebar-toc-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-vector-page-titlebar-toc" class="vector-dropdown-checkbox " aria-label="Toggle the table of contents" > <label id="vector-page-titlebar-toc-label" for="vector-page-titlebar-toc-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--icon-only " aria-hidden="true" ><span class="vector-icon mw-ui-icon-listBullet mw-ui-icon-wikimedia-listBullet"></span> <span class="vector-dropdown-label-text">Toggle the table of contents</span> </label> <div class="vector-dropdown-content"> <div id="vector-page-titlebar-toc-unpinned-container" class="vector-unpinned-container"> </div> </div> </div> </nav> <h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Amlodipine</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 39 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-39" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">39 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-af mw-list-item"><a href="https://af.wikipedia.org/wiki/Amlodipien" title="Amlodipien – Afrikaans" lang="af" hreflang="af" data-title="Amlodipien" data-language-autonym="Afrikaans" data-language-local-name="Afrikaans" class="interlanguage-link-target"><span>Afrikaans</span></a></li><li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D8%A3%D9%85%D9%84%D9%88%D8%AF%D9%8A%D8%A8%D9%8A%D9%86" title="أملوديبين – Arabic" lang="ar" hreflang="ar" data-title="أملوديبين" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-azb mw-list-item"><a href="https://azb.wikipedia.org/wiki/%D8%A2%D9%85%D9%84%D9%88%D8%AF%DB%8C%D9%BE%DB%8C%D9%86" title="آملودیپین – South Azerbaijani" lang="azb" hreflang="azb" data-title="آملودیپین" data-language-autonym="تۆرکجه" data-language-local-name="South Azerbaijani" class="interlanguage-link-target"><span>تۆرکجه</span></a></li><li class="interlanguage-link interwiki-bn mw-list-item"><a href="https://bn.wikipedia.org/wiki/%E0%A6%85%E0%A7%8D%E0%A6%AF%E0%A6%BE%E0%A6%AE%E0%A6%B2%E0%A7%8B%E0%A6%A1%E0%A6%BF%E0%A6%AA%E0%A6%BF%E0%A6%A8" title="অ্যামলোডিপিন – Bangla" lang="bn" hreflang="bn" data-title="অ্যামলোডিপিন" data-language-autonym="বাংলা" data-language-local-name="Bangla" class="interlanguage-link-target"><span>বাংলা</span></a></li><li class="interlanguage-link interwiki-bg mw-list-item"><a href="https://bg.wikipedia.org/wiki/%D0%90%D0%BC%D0%BB%D0%BE%D0%B4%D0%B8%D0%BF%D0%B8%D0%BD" title="Амлодипин – Bulgarian" lang="bg" hreflang="bg" data-title="Амлодипин" data-language-autonym="Български" data-language-local-name="Bulgarian" class="interlanguage-link-target"><span>Български</span></a></li><li class="interlanguage-link interwiki-ca mw-list-item"><a href="https://ca.wikipedia.org/wiki/Amlodipina" title="Amlodipina – Catalan" lang="ca" hreflang="ca" data-title="Amlodipina" data-language-autonym="Català" data-language-local-name="Catalan" class="interlanguage-link-target"><span>Català</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Welsh" lang="cy" hreflang="cy" data-title="Amlodipin" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-da mw-list-item"><a href="https://da.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Danish" lang="da" hreflang="da" data-title="Amlodipin" data-language-autonym="Dansk" data-language-local-name="Danish" class="interlanguage-link-target"><span>Dansk</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/Amlodipin" title="Amlodipin – German" lang="de" hreflang="de" data-title="Amlodipin" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-el mw-list-item"><a href="https://el.wikipedia.org/wiki/%CE%91%CE%BC%CE%BB%CE%BF%CE%B4%CE%B9%CF%80%CE%AF%CE%BD%CE%B7" title="Αμλοδιπίνη – Greek" lang="el" hreflang="el" data-title="Αμλοδιπίνη" data-language-autonym="Ελληνικά" data-language-local-name="Greek" class="interlanguage-link-target"><span>Ελληνικά</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/Amlodipino" title="Amlodipino – Spanish" lang="es" hreflang="es" data-title="Amlodipino" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-eu mw-list-item"><a href="https://eu.wikipedia.org/wiki/Amlodipino" title="Amlodipino – Basque" lang="eu" hreflang="eu" data-title="Amlodipino" data-language-autonym="Euskara" data-language-local-name="Basque" class="interlanguage-link-target"><span>Euskara</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/%D8%A2%D9%85%D9%84%D9%88%D8%AF%DB%8C%D9%BE%DB%8C%D9%86" title="آملودیپین – Persian" lang="fa" hreflang="fa" data-title="آملودیپین" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/Amlodipine" title="Amlodipine – French" lang="fr" hreflang="fr" data-title="Amlodipine" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/%EC%95%94%EB%A1%9C%EB%94%94%ED%95%80" title="암로디핀 – Korean" lang="ko" hreflang="ko" data-title="암로디핀" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-hy mw-list-item"><a href="https://hy.wikipedia.org/wiki/%D4%B1%D5%B4%D5%AC%D5%B8%D5%A4%D5%AB%D5%BA%D5%AB%D5%B6" title="Ամլոդիպին – Armenian" lang="hy" hreflang="hy" data-title="Ամլոդիպին" data-language-autonym="Հայերեն" data-language-local-name="Armenian" class="interlanguage-link-target"><span>Հայերեն</span></a></li><li class="interlanguage-link interwiki-id mw-list-item"><a href="https://id.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Indonesian" lang="id" hreflang="id" data-title="Amlodipin" data-language-autonym="Bahasa Indonesia" data-language-local-name="Indonesian" class="interlanguage-link-target"><span>Bahasa Indonesia</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/Amlodipina" title="Amlodipina – Italian" lang="it" hreflang="it" data-title="Amlodipina" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/%D7%90%D7%9E%D7%9C%D7%95%D7%93%D7%99%D7%A4%D7%99%D7%9F" title="אמלודיפין – Hebrew" lang="he" hreflang="he" data-title="אמלודיפין" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-lv mw-list-item"><a href="https://lv.wikipedia.org/wiki/Amlodip%C4%ABns" title="Amlodipīns – Latvian" lang="lv" hreflang="lv" data-title="Amlodipīns" data-language-autonym="Latviešu" data-language-local-name="Latvian" class="interlanguage-link-target"><span>Latviešu</span></a></li><li class="interlanguage-link interwiki-hu mw-list-item"><a href="https://hu.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Hungarian" lang="hu" hreflang="hu" data-title="Amlodipin" data-language-autonym="Magyar" data-language-local-name="Hungarian" class="interlanguage-link-target"><span>Magyar</span></a></li><li class="interlanguage-link interwiki-ml mw-list-item"><a href="https://ml.wikipedia.org/wiki/%E0%B4%85%E0%B4%82%E0%B4%B2%E0%B5%8B%E0%B4%A1%E0%B4%BF%E0%B4%AA%E0%B4%BF%E0%B5%BB" title="അംലോഡിപിൻ – Malayalam" lang="ml" hreflang="ml" data-title="അംലോഡിപിൻ" data-language-autonym="മലയാളം" data-language-local-name="Malayalam" class="interlanguage-link-target"><span>മലയാളം</span></a></li><li class="interlanguage-link interwiki-min mw-list-item"><a href="https://min.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Minangkabau" lang="min" hreflang="min" data-title="Amlodipin" data-language-autonym="Minangkabau" data-language-local-name="Minangkabau" class="interlanguage-link-target"><span>Minangkabau</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/Amlodipine" title="Amlodipine – Dutch" lang="nl" hreflang="nl" data-title="Amlodipine" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/%E3%82%A2%E3%83%A0%E3%83%AD%E3%82%B8%E3%83%94%E3%83%B3" title="アムロジピン – Japanese" lang="ja" hreflang="ja" data-title="アムロジピン" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-or mw-list-item"><a href="https://or.wikipedia.org/wiki/%E0%AC%86%E0%AC%AE%E0%AD%8D%E0%AC%B2%E0%AD%8B%E0%AC%A1%E0%AC%BF%E0%AC%AA%E0%AC%BF%E0%AC%A8" title="ଆମ୍ଲୋଡିପିନ – Odia" lang="or" hreflang="or" data-title="ଆମ୍ଲୋଡିପିନ" data-language-autonym="ଓଡ଼ିଆ" data-language-local-name="Odia" class="interlanguage-link-target"><span>ଓଡ଼ିଆ</span></a></li><li class="interlanguage-link interwiki-pl mw-list-item"><a href="https://pl.wikipedia.org/wiki/Amlodypina" title="Amlodypina – Polish" lang="pl" hreflang="pl" data-title="Amlodypina" data-language-autonym="Polski" data-language-local-name="Polish" class="interlanguage-link-target"><span>Polski</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/Amlodipina" title="Amlodipina – Portuguese" lang="pt" hreflang="pt" data-title="Amlodipina" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ro mw-list-item"><a href="https://ro.wikipedia.org/wiki/Amlodipin%C4%83" title="Amlodipină – Romanian" lang="ro" hreflang="ro" data-title="Amlodipină" data-language-autonym="Română" data-language-local-name="Romanian" class="interlanguage-link-target"><span>Română</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/%D0%90%D0%BC%D0%BB%D0%BE%D0%B4%D0%B8%D0%BF%D0%B8%D0%BD" title="Амлодипин – Russian" lang="ru" hreflang="ru" data-title="Амлодипин" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Serbian" lang="sr" hreflang="sr" data-title="Amlodipin" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Serbo-Croatian" lang="sh" hreflang="sh" data-title="Amlodipin" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-fi mw-list-item"><a href="https://fi.wikipedia.org/wiki/Amlodipiini" title="Amlodipiini – Finnish" lang="fi" hreflang="fi" data-title="Amlodipiini" data-language-autonym="Suomi" data-language-local-name="Finnish" class="interlanguage-link-target"><span>Suomi</span></a></li><li class="interlanguage-link interwiki-ta mw-list-item"><a href="https://ta.wikipedia.org/wiki/%E0%AE%85%E0%AE%AE%E0%AF%8D%E0%AE%B2%E0%AF%8B%E0%AE%9F%E0%AE%BF%E0%AE%AA%E0%AE%BF%E0%AE%A9%E0%AF%8D" title="அம்லோடிபின் – Tamil" lang="ta" hreflang="ta" data-title="அம்லோடிபின்" data-language-autonym="தமிழ்" data-language-local-name="Tamil" class="interlanguage-link-target"><span>தமிழ்</span></a></li><li class="interlanguage-link interwiki-th mw-list-item"><a href="https://th.wikipedia.org/wiki/%E0%B9%81%E0%B8%AD%E0%B8%A1%E0%B9%82%E0%B8%A5%E0%B8%94%E0%B8%B4%E0%B8%9E%E0%B8%B5%E0%B8%99" title="แอมโลดิพีน – Thai" lang="th" hreflang="th" data-title="แอมโลดิพีน" data-language-autonym="ไทย" data-language-local-name="Thai" class="interlanguage-link-target"><span>ไทย</span></a></li><li class="interlanguage-link interwiki-tr mw-list-item"><a href="https://tr.wikipedia.org/wiki/Amlodipin" title="Amlodipin – Turkish" lang="tr" hreflang="tr" data-title="Amlodipin" data-language-autonym="Türkçe" data-language-local-name="Turkish" class="interlanguage-link-target"><span>Türkçe</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/%D0%90%D0%BC%D0%BB%D0%BE%D0%B4%D0%B8%D0%BF%D1%96%D0%BD" title="Амлодипін – Ukrainian" lang="uk" hreflang="uk" data-title="Амлодипін" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/Amlodipine" title="Amlodipine – Vietnamese" lang="vi" hreflang="vi" data-title="Amlodipine" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/%E6%B0%A8%E6%B0%AF%E5%9C%B0%E5%B9%B3" title="氨氯地平 – Chinese" lang="zh" hreflang="zh" data-title="氨氯地平" data-language-autonym="中文" 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class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Medication against high blood pressure</div> <p class="mw-empty-elt"> </p> <div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Pharmaceutical compound</div> <style data-mw-deduplicate="TemplateStyles:r1269284339">@media screen{html.skin-theme-clientpref-night .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .dark_mode_safe img{background-color:var(--background-color-inverted,#f8f9fa)}}</style> <style data-mw-deduplicate="TemplateStyles:r1257001546">.mw-parser-output .infobox-subbox{padding:0;border:none;margin:-3px;width:auto;min-width:100%;font-size:100%;clear:none;float:none;background-color:transparent}.mw-parser-output .infobox-3cols-child{margin:auto}.mw-parser-output .infobox .navbar{font-size:100%}@media screen{html.skin-theme-clientpref-night .mw-parser-output .infobox-full-data:not(.notheme)>div:not(.notheme)[style]{background:#1f1f23!important;color:#f8f9fa}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .infobox-full-data:not(.notheme) div:not(.notheme){background:#1f1f23!important;color:#f8f9fa}}@media(min-width:640px){body.skin--responsive .mw-parser-output .infobox-table{display:table!important}body.skin--responsive .mw-parser-output .infobox-table>caption{display:table-caption!important}body.skin--responsive .mw-parser-output .infobox-table>tbody{display:table-row-group}body.skin--responsive .mw-parser-output .infobox-table tr{display:table-row!important}body.skin--responsive .mw-parser-output .infobox-table th,body.skin--responsive .mw-parser-output .infobox-table td{padding-left:inherit;padding-right:inherit}}</style><table class="infobox" style="border-spacing:2px;"><caption class="infobox-title"><span title="International nonproprietary name (INN): Amlodipine">Amlodipine</span></caption><tbody><tr><td colspan="2" class="infobox-image"><span class="skin-invert-image" typeof="mw:File"><a href="/wiki/File:Amlodipine.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Amlodipine.svg/230px-Amlodipine.svg.png" decoding="async" width="230" height="134" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Amlodipine.svg/345px-Amlodipine.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1d/Amlodipine.svg/460px-Amlodipine.svg.png 2x" data-file-width="561" data-file-height="326" /></a></span></td></tr><tr><td colspan="2" class="infobox-image"><span class="dark_mode_safe" typeof="mw:File"><a href="/wiki/File:Amlodipine_3D_ball.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/f/f3/Amlodipine_3D_ball.png/200px-Amlodipine_3D_ball.png" decoding="async" width="200" height="167" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/f/f3/Amlodipine_3D_ball.png/300px-Amlodipine_3D_ball.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/f/f3/Amlodipine_3D_ball.png/400px-Amlodipine_3D_ball.png 2x" data-file-width="2000" data-file-height="1668" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Clinical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">Pronunciation</th><td class="infobox-data"><span class="rt-commentedText nowrap"><span class="IPA nopopups noexcerpt" lang="en-fonipa"><a href="/wiki/Help:IPA/English" title="Help:IPA/English">/<span style="border-bottom:1px dotted"><span title="/æ/: 'a' in 'bad'">æ</span><span title="'m' in 'my'">m</span><span title="/ˈ/: primary stress follows">ˈ</span><span title="'l' in 'lie'">l</span><span title="/oʊ/: 'o' in 'code'">oʊ</span><span title="'d' in 'dye'">d</span><span title="/ɪ/: 'i' in 'kit'">ɪ</span><span title="/ˌ/: secondary stress follows">ˌ</span><span title="'p' in 'pie'">p</span><span title="/iː/: 'ee' in 'fleece'">iː</span><span title="'n' in 'nigh'">n</span></span>/</a></span></span><sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_nomenclature#Trade_names" title="Drug nomenclature">Trade names</a></th><td class="infobox-data">Norvasc, others</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/American_Society_of_Health-System_Pharmacists" title="American Society of Health-System Pharmacists">AHFS</a>/<a href="/wiki/Drugs.com" title="Drugs.com">Drugs.com</a></th><td class="infobox-data"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/amlodipine.html">Monograph</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus</a></th><td class="infobox-data"><span title="medlineplus.gov"><a rel="nofollow" class="external text" href="https://medlineplus.gov/druginfo/meds/a692044.html">a692044</a></span></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">License data</a></th><td class="infobox-data"><style data-mw-deduplicate="TemplateStyles:r1126788409">.mw-parser-output .plainlist ol,.mw-parser-output .plainlist ul{line-height:inherit;list-style:none;margin:0;padding:0}.mw-parser-output .plainlist ol li,.mw-parser-output .plainlist ul li{margin-bottom:0}</style><div class="plainlist"> <ul><li><small><abbr class="country-name" title="United States">US</abbr></small> <a href="/wiki/DailyMed" title="DailyMed">DailyMed</a>: <span title="dailymed.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/search.cfm?labeltype=all&query=Amlodipine">Amlodipine</a></span></li></ul></div> </td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pregnancy_category" title="Pregnancy category">Pregnancy<br />category</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> C<sup id="cite_ref-Drugs.com_pregnancy_2-0" class="reference"><a href="#cite_note-Drugs.com_pregnancy-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></li> <li class="mw-empty-elt"></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Route_of_administration" title="Route of administration">Routes of<br />administration</a></th><td class="infobox-data"><a href="/wiki/Oral_administration" title="Oral administration">Oral</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_class" title="Drug class">Drug class</a></th><td class="infobox-data"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Calcium channel blocker</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Anatomical_Therapeutic_Chemical_Classification_System" title="Anatomical Therapeutic Chemical Classification System">ATC code</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><a href="/wiki/ATC_code_C08" title="ATC code C08">C08CA01</a> (<span title="www.whocc.no"><a rel="nofollow" class="external text" href="https://www.whocc.no/atc_ddd_index/?code=C08CA01">WHO</a></span>) </li></ul></div></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Legal status</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Regulation_of_therapeutic_goods" title="Regulation of therapeutic goods">Legal status</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"> <ul><li><small><abbr class="country-name" title="Australia">AU</abbr>:</small> <a href="/wiki/Standard_for_the_Uniform_Scheduling_of_Medicines_and_Poisons#Schedule_4" title="Standard for the Uniform Scheduling of Medicines and Poisons">S4</a> (Prescription only)<sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="Canada">CA</abbr></small>: <a href="/wiki/Prescription_drug" title="Prescription drug"> ℞-only</a><sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United Kingdom">UK</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">POM</a> (Prescription only)<sup id="cite_ref-Istin_SmPC_6-0" class="reference"><a href="#cite_note-Istin_SmPC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="United States">US</abbr>:</small> <a href="/wiki/Prescription_drug" title="Prescription drug">℞-only</a><sup id="cite_ref-Norvasc_FDA_label_7-0" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Norliqva_FDA_label_8-0" class="reference"><a href="#cite_note-Norliqva_FDA_label-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup></li> <li><small><abbr class="country-name" title="European Union">EU</abbr>:</small> Rx-only<sup id="cite_ref-9" class="reference"><a href="#cite_note-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup></li> <li>In general: ℞ (Prescription only)</li></ul></div> </td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;"><a href="/wiki/Pharmacokinetics" title="Pharmacokinetics">Pharmacokinetic</a> data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Bioavailability" title="Bioavailability">Bioavailability</a></th><td class="infobox-data">64–90%</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Plasma_protein_binding" title="Plasma protein binding">Protein binding</a></th><td class="infobox-data">93%<sup id="cite_ref-Norvasc_FDA_label_7-1" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Drug_metabolism" title="Drug metabolism">Metabolism</a></th><td class="infobox-data"><a href="/wiki/Liver" title="Liver">Liver</a></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Metabolite" title="Metabolite">Metabolites</a></th><td class="infobox-data">Various inactive pyrimidine metabolites</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Onset_of_action" title="Onset of action">Onset of action</a></th><td class="infobox-data">Highest availability 6–12 hours after oral dose<sup id="cite_ref-ASHP2016_10-0" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Biological_half-life" title="Biological half-life">Elimination <span class="nowrap">half-life</span></a></th><td class="infobox-data">30–50 hours</td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Pharmacodynamics#Duration_of_action" title="Pharmacodynamics">Duration of action</a></th><td class="infobox-data">At least 24 hours<sup id="cite_ref-ASHP2016_10-1" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Excretion" title="Excretion">Excretion</a></th><td class="infobox-data"><a href="/wiki/Urine" title="Urine">Urine</a><sup id="cite_ref-ASHP2016_10-2" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Identifiers</th></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/IUPAC_nomenclature_of_chemistry" title="IUPAC nomenclature of chemistry">IUPAC name</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all; text-align:left; padding-left:1.5em; text-indent:-1.5em;"><li style="line-height: inherit; margin: 0"><div style="font-size: 97%;">(<i>RS</i>)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate</div></li></ul> </div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CAS_Registry_Number" title="CAS Registry Number">CAS Number</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="commonchemistry.cas.org"><a rel="nofollow" class="external text" href="https://commonchemistry.cas.org/detail?cas_rn=88150-42-9">88150-42-9</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/PubChem#CID" title="PubChem">PubChem</a> <span style="font-weight:normal"><abbr title="Compound ID">CID</abbr></span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="pubchem.ncbi.nlm.nih.gov"><a rel="nofollow" class="external text" href="https://pubchem.ncbi.nlm.nih.gov/compound/2162">2162</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Guide_to_Pharmacology" title="Guide to Pharmacology">IUPHAR/BPS</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.guidetopharmacology.org"><a rel="nofollow" class="external text" href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=6981">6981</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/DrugBank" title="DrugBank">DrugBank</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.drugbank.ca"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00381">DB00381</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChemSpider" title="ChemSpider">ChemSpider</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.chemspider.com"><a rel="nofollow" class="external text" href="https://www.chemspider.com/Chemical-Structure.2077.html">2077</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Unique_Ingredient_Identifier" title="Unique Ingredient Identifier">UNII</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="precision.fda.gov"><a rel="nofollow" class="external text" href="https://precision.fda.gov/uniisearch/srs/unii/1J444QC288">1J444QC288</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/KEGG" title="KEGG">KEGG</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.kegg.jp"><a rel="nofollow" class="external text" href="https://www.kegg.jp/entry/D07450">D07450</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEBI" title="ChEBI">ChEBI</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:2668">CHEBI:2668</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ChEMBL" title="ChEMBL">ChEMBL</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/chembl/explore/compound/ChEMBL1491">ChEMBL1491</a></span><sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB ligand</a></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li>6UB (<span title="www.ebi.ac.uk"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=6UB">PDBe</a></span>, <span title="www.rcsb.org"><a rel="nofollow" class="external text" href="https://www.rcsb.org/ligand/6UB">RCSB PDB</a></span>)</li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/CompTox_Chemicals_Dashboard" title="CompTox Chemicals Dashboard">CompTox Dashboard</a> <span style="font-weight:normal">(<abbr title="U.S. Environmental Protection Agency">EPA</abbr>)</span></th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="comptox.epa.gov"><a rel="nofollow" class="external text" href="https://comptox.epa.gov/dashboard/chemical/details/DTXSID7022596">DTXSID7022596</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q411347#P3117" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/ECHA_InfoCard" class="mw-redirect" title="ECHA InfoCard"><span title="echa.europa.eu">ECHA InfoCard</span></a></th><td class="infobox-data"><a rel="nofollow" class="external text" href="https://echa.europa.eu/substance-information/-/substanceinfo/100.102.428">100.102.428</a> <span class="mw-valign-text-top noprint" typeof="mw:File/Frameless"><a href="https://www.wikidata.org/wiki/Q411347#P2566" title="Edit this at Wikidata"><img alt="Edit this at Wikidata" src="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/10px-OOjs_UI_icon_edit-ltr-progressive.svg.png" decoding="async" width="10" height="10" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/15px-OOjs_UI_icon_edit-ltr-progressive.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/8/8a/OOjs_UI_icon_edit-ltr-progressive.svg/20px-OOjs_UI_icon_edit-ltr-progressive.svg.png 2x" data-file-width="20" data-file-height="20" /></a></span></td></tr><tr><th colspan="2" class="infobox-header" style="background:#ddd;color:inherit;">Chemical and physical data</th></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chemical_formula" title="Chemical formula">Formula</a></th><td class="infobox-data"><span title="Carbon">C</span><sub>20</sub><span title="Hydrogen">H</span><sub>25</sub><span title="Chlorine">Cl</span><span title="Nitrogen">N</span><sub>2</sub><span title="Oxygen">O</span><sub>5</sub></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Molar_mass" title="Molar mass">Molar mass</a></th><td class="infobox-data"><span class="nowrap"><span data-sort-value="7002408880000000000♠"></span>408.88</span> g·mol<sup>−1</sup></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;">3D model (<a href="/wiki/JSmol" class="mw-redirect" title="JSmol">JSmol</a>)</th><td class="infobox-data"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1126788409" /><div class="plainlist"><ul><li><span title="chemapps.stolaf.edu (3D interactive model)"><a rel="nofollow" class="external text" href="https://chemapps.stolaf.edu/jmol/jmol.php?model=Clc1ccccc1C2%2FC%28C%28%3DO%29OC%29%3DC%28%2FC%29N%2FC%28COCCN%29%3DC2%2FC%28%3DO%29OCC">Interactive image</a></span></li></ul></div></td></tr><tr><th scope="row" class="infobox-label" style="line-height:1.2em;"><a href="/wiki/Chirality_(chemistry)" title="Chirality (chemistry)">Chirality</a></th><td class="infobox-data"><a href="/wiki/Racemic_mixture" title="Racemic mixture">Racemic mixture</a></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/Simplified_molecular-input_line-entry_system" class="mw-redirect" title="Simplified molecular-input line-entry system">SMILES</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Clc1ccccc1C2/C(C(=O)OC)=C(/C)N/C(COCCN)=C2/C(=O)OCC</div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-full-data"><div class="collapsible-list mw-collapsible mw-collapsed" style="text-align: left;"> <div style="line-height: 1.6em; font-weight: bold;"><div><a href="/wiki/International_Chemical_Identifier" title="International Chemical Identifier">InChI</a></div></div> <ul class="mw-collapsible-content" style="margin-top: 0; margin-bottom: 0; line-height: inherit; list-style: none; margin-left: 0; word-break:break-all;"><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li><li style="line-height: inherit; margin: 0"><div style="word-wrap:break-word; text-indent:-1.5em; text-align:left; padding-left:1.5em; font-size:97%; line-height:120%;">Key:HTIQEAQVCYTUBX-UHFFFAOYSA-N<sup> <span typeof="mw:File"><span><img alt="check" src="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/7px-Yes_check.svg.png" decoding="async" width="7" height="7" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/11px-Yes_check.svg.png 1.5x, //upload.wikimedia.org/wikipedia/en/thumb/f/fb/Yes_check.svg/14px-Yes_check.svg.png 2x" data-file-width="600" data-file-height="600" /></span></span><span style="display:none">Y</span></sup></div></li></ul> </div></td></tr><tr><td colspan="2" class="infobox-below"><style data-mw-deduplicate="TemplateStyles:r886047488">.mw-parser-output .nobold{font-weight:normal}</style><span class="nobold">  <span class="reflink plainlinks nourlexpansion"><a class="external text" href="https://en.wikipedia.org/w/index.php?title=Special:ComparePages&rev1=456689822&page2=Amlodipine">(verify)</a></span></span></td></tr></tbody></table> <p><b>Amlodipine</b>, sold under the brand name <b>Norvasc</b> among others, is a <a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">calcium channel blocker</a> medication used to treat <a href="/wiki/Hypertension" title="Hypertension">high blood pressure</a>, <a href="/wiki/Coronary_artery_disease" title="Coronary artery disease">coronary artery disease</a> (CAD)<sup id="cite_ref-ASHP2016_10-3" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Variant_angina" title="Variant angina">variant angina</a> (also called Prinzmetal angina or coronary artery vasospasm, among other names).<sup id="cite_ref-Goldmancecil_11-0" class="reference"><a href="#cite_note-Goldmancecil-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> It is taken <a href="/wiki/Oral_administration" title="Oral administration">orally</a> (swallowed by mouth).<sup id="cite_ref-ASHP2016_10-4" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Common side effects include <a href="/wiki/Edema" title="Edema">swelling</a>, <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">feeling tired</a>, <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a>, and <a href="/wiki/Nausea" title="Nausea">nausea</a>.<sup id="cite_ref-ASHP2016_10-5" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Serious side effects may include <a href="/wiki/Hypotension" title="Hypotension">low blood pressure</a> or <a href="/wiki/Myocardial_infarction" title="Myocardial infarction">heart attack</a>.<sup id="cite_ref-ASHP2016_10-6" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Whether use is safe during <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> or <a href="/wiki/Breastfeeding" title="Breastfeeding">breastfeeding</a> is unclear.<sup id="cite_ref-Drugs.com_pregnancy_2-1" class="reference"><a href="#cite_note-Drugs.com_pregnancy-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ASHP2016_10-7" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> When used by people with <a href="/wiki/Liver_problems" class="mw-redirect" title="Liver problems">liver problems</a>, and in elderly individuals, doses should be reduced.<sup id="cite_ref-ASHP2016_10-8" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Amlodipine works partly by <a href="/wiki/Vasodilation" title="Vasodilation">vasodilation</a> (relaxing the arteries and increasing their diameter).<sup id="cite_ref-ASHP2016_10-9" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> It is a long-acting <a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">calcium channel blocker</a> of the <a href="/wiki/Dihydropyridine" class="mw-redirect" title="Dihydropyridine">dihydropyridine</a> type.<sup id="cite_ref-ASHP2016_10-10" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine was patented in 1982, and approved for medical use in 1990.<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> It is on the <a href="/wiki/WHO_Model_List_of_Essential_Medicines" title="WHO Model List of Essential Medicines">World Health Organization's List of Essential Medicines</a>.<sup id="cite_ref-WHO23rd_13-0" class="reference"><a href="#cite_note-WHO23rd-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup> It is available as a <a href="/wiki/Generic_medication" class="mw-redirect" title="Generic medication">generic medication</a>.<sup id="cite_ref-ASHP2016_10-11" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> In 2022, it was the fifth most commonly prescribed medication in the United States, with more than 70<span class="nowrap"> </span>million prescriptions.<sup id="cite_ref-15" class="reference"><a href="#cite_note-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-16" class="reference"><a href="#cite_note-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> In Australia, it was one of the top 10 most prescribed medications between 2017 and 2023.<sup id="cite_ref-17" class="reference"><a href="#cite_note-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Medical_uses">Medical uses</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=1" title="Edit section: Medical uses"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amlodipine is used in the management of hypertension (high blood pressure)<sup id="cite_ref-18" class="reference"><a href="#cite_note-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> and coronary artery disease in people with either stable <a href="/wiki/Angina" title="Angina">angina</a> (where chest pain occurs mostly after physical or emotional stress)<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> or <a href="/wiki/Vasospastic_angina" class="mw-redirect" title="Vasospastic angina">vasospastic angina</a> (where it occurs in cycles) and without <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a>. It can be used as either monotherapy or <a href="/wiki/Combination_therapy" title="Combination therapy">combination therapy</a> for the management of hypertension or coronary artery disease. Amlodipine can be administered to adults and to children 6–17 years of age.<sup id="cite_ref-Norvasc_FDA_label_7-2" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Calcium channel blockers, including amlodipine, may provide greater protection against <a href="/wiki/Stroke" title="Stroke">stroke</a> than <a href="/wiki/Beta_blockers" class="mw-redirect" title="Beta blockers">beta blockers</a>.<sup id="cite_ref-Chen_2013_20-0" class="reference"><a href="#cite_note-Chen_2013-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Mukete_2015_21-0" class="reference"><a href="#cite_note-Mukete_2015-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> Evidence from two meta-analyses has reported no significant difference between calcium channel blockers, <a href="/wiki/ACE_inhibitor" title="ACE inhibitor">ACE inhibitors</a>, <a href="/wiki/Diuretic" title="Diuretic">diuretics</a> <sup id="cite_ref-Iyengar_2021_22-0" class="reference"><a href="#cite_note-Iyengar_2021-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Chen_2013_20-1" class="reference"><a href="#cite_note-Chen_2013-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> and <a href="/wiki/Angiotensin_II_receptor_blocker" title="Angiotensin II receptor blocker">angiotensin receptor blockers</a><sup id="cite_ref-Iyengar_2021_22-1" class="reference"><a href="#cite_note-Iyengar_2021-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> in stroke protection while one 2015 meta-analysis has suggested that calcium channel blockers offer greater protection against stroke than other classes of <a href="/wiki/Antihypertensive_drug" class="mw-redirect" title="Antihypertensive drug">antihypertensive</a>.<sup id="cite_ref-Mukete_2015_21-1" class="reference"><a href="#cite_note-Mukete_2015-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine along with other calcium channel blockers are considered the first choice in the pharmacological management of <a href="/wiki/Raynaud%27s_phenomenon" class="mw-redirect" title="Raynaud's phenomenon">Raynaud's phenomenon</a>.<sup id="cite_ref-Baumhäkel_Böhm_pp._207–214_23-0" class="reference"><a href="#cite_note-Baumhäkel_Böhm_pp._207–214-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-n686_24-0" class="reference"><a href="#cite_note-n686-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Combination_therapy">Combination therapy</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=2" title="Edit section: Combination therapy"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amlodipine can be given as a combination therapy with a variety of medications:<sup id="cite_ref-ASHP2016_10-12" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Amlodipine/atorvastatin" title="Amlodipine/atorvastatin">Amlodipine/atorvastatin</a>, where amlodipine is given for hypertension or CAD and atorvastatin prevents cardiovascular events, or if the person also has high cholesterol.</li> <li><a href="/wiki/Aliskiren/amlodipine" title="Aliskiren/amlodipine">Amlodipine/aliskiren</a> or <a href="/wiki/Aliskiren/amlodipine/hydrochlorothiazide" title="Aliskiren/amlodipine/hydrochlorothiazide">amlodipine/aliskiren/hydrochlorothiazide</a> if amlodipine alone cannot reduce blood pressure. <a href="/wiki/Aliskiren" title="Aliskiren">Aliskiren</a> is a <a href="/wiki/Renin_inhibitor" title="Renin inhibitor">renin inhibitor</a>, which works to reduce <a href="/wiki/Primary_hypertension" class="mw-redirect" title="Primary hypertension">primary hypertension</a> (that with no known cause) by binding to <a href="/wiki/Renin" title="Renin">renin</a> and preventing it from initiating the <a href="/wiki/Renin%E2%80%93angiotensin_system" title="Renin–angiotensin system">renin–angiotensin system</a> (RAAS) pathway to increase blood pressure. <a href="/wiki/Hydrochlorothiazide" title="Hydrochlorothiazide">Hydrochlorothiazide</a> is a diuretic and decreases overall blood volume.</li> <li><a href="/wiki/Amlodipine/benazepril" title="Amlodipine/benazepril">Amlodipine/benazepril</a> if either drug has failed individually, or amlodipine alone caused <a href="/wiki/Edema" title="Edema">edema</a>. <a href="/wiki/Benazepril" title="Benazepril">Benazepril</a> is an ACE inhibitor and blocks the conversion of <a href="/wiki/Angiotensin_I" class="mw-redirect" title="Angiotensin I">angiotensin I</a> to <a href="/wiki/Angiotensin_II" class="mw-redirect" title="Angiotensin II">angiotensin II</a> in the RAAS pathway.</li> <li><a href="/wiki/Amlodipine/celecoxib" title="Amlodipine/celecoxib">Amlodipine/celecoxib</a></li> <li><a href="/wiki/Lisinopril/amlodipine" title="Lisinopril/amlodipine">Amlodipine/lisinopril</a></li> <li><a href="/wiki/Olmesartan/amlodipine" class="mw-redirect" title="Olmesartan/amlodipine">Amlodipine/olmesartan</a> or <a href="/wiki/Olmesartan/amlodipine/hydrochlorothiazide" title="Olmesartan/amlodipine/hydrochlorothiazide">amlodipine/olmesartan/hydrochlorothiazide</a> if amlodipine is insufficient in reducing blood pressure. <a href="/wiki/Olmesartan" title="Olmesartan">Olmesartan</a> is an <a href="/wiki/Angiotensin_II_receptor_antagonist" class="mw-redirect" title="Angiotensin II receptor antagonist">angiotensin II receptor antagonist</a> and blocks part of the RAAS pathway.</li> <li><a href="/wiki/Amlodipine/perindopril" class="mw-redirect" title="Amlodipine/perindopril">Amlodipine/perindopril</a> if using amlodipine alone caused <a href="/wiki/Edema" title="Edema">edema</a>. <a href="/wiki/Perindopril" title="Perindopril">Perindopril</a> is a long-lasting ACE inhibitor.</li> <li><a href="/wiki/Telmisartan/amlodipine" title="Telmisartan/amlodipine">Amlodipine/telmisartan</a>, where <a href="/wiki/Telmisartan" title="Telmisartan">telmisartan</a> is an angiotensin II receptor antagonist.</li> <li><a href="/wiki/Amlodipine/valsartan" title="Amlodipine/valsartan">Amlodipine/valsartan</a> or amlodipine/valsartan/hydrochlorothiazide, where <a href="/wiki/Valsartan" title="Valsartan">valsartan</a> is an angiotensin II receptor antagonist.</li></ul> <div class="mw-heading mw-heading2"><h2 id="Contraindications">Contraindications</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=3" title="Edit section: Contraindications"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The only absolute <a href="/wiki/Contraindication" title="Contraindication">contraindication</a> to amlodipine is an allergy to amlodipine or any other dihydropyridines.<sup id="cite_ref-Norvasc_FDA_label_7-3" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Other situations occur, however, where amlodipine generally should not be used. In patients with <a href="/wiki/Cardiogenic_shock" title="Cardiogenic shock">cardiogenic shock</a>, where the heart's ventricles are not able to pump enough blood, calcium channel blockers exacerbate the situation by preventing the flow of calcium ions into cardiac cells, which is required for the heart to pump.<sup id="cite_ref-diseaseinter_26-0" class="reference"><a href="#cite_note-diseaseinter-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup> While use in patients with <a href="/wiki/Aortic_stenosis" title="Aortic stenosis">aortic stenosis</a> (narrowing of the <a href="/wiki/Aorta" title="Aorta">aorta</a> where it meets the <a href="/wiki/Left_ventricle" class="mw-redirect" title="Left ventricle">left ventricle</a>) since it does not inhibit the ventricle's function is generally safe, it can still cause collapse in cases of severe stenosis.<sup id="cite_ref-27" class="reference"><a href="#cite_note-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> In <a href="/wiki/Unstable_angina" title="Unstable angina">unstable angina</a> (excluding <a href="/wiki/Variant_angina" title="Variant angina">variant angina</a>), amlodipine can cause a <a href="/wiki/Baroreflex" title="Baroreflex">reflex</a> increase in <a href="/wiki/Inotrope" title="Inotrope">cardiac contractility (how hard the ventricles squeeze)</a> and <a href="/wiki/Chronotropic" title="Chronotropic">heart rate</a>, which together increase the demand for oxygen by the heart itself.<sup id="cite_ref-hitchings_28-0" class="reference"><a href="#cite_note-hitchings-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> Patients with severe <a href="/wiki/Hypotension" title="Hypotension">hypotension</a> can have their low blood pressure exacerbated, and patients in <a href="/wiki/Heart_failure" title="Heart failure">heart failure</a> can get <a href="/wiki/Pulmonary_edema" title="Pulmonary edema">pulmonary edema</a>. Those with impaired <a href="/wiki/Liver_function" class="mw-redirect" title="Liver function">liver function</a> are unable to metabolize amlodipine to its full extent, giving it a longer half-life than typical.<sup id="cite_ref-Norvasc_FDA_label_7-4" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Istin_SmPC_6-1" class="reference"><a href="#cite_note-Istin_SmPC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine's safety in <a href="/wiki/Pregnancy" title="Pregnancy">pregnancy</a> has not been established, although reproductive toxicity at high doses is known. Whether amlodipine enters the milk of breastfeeding mothers is also unknown.<sup id="cite_ref-Norvasc_FDA_label_7-5" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Istin_SmPC_6-2" class="reference"><a href="#cite_note-Istin_SmPC-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup> </p><p>Those who have heart failure, or recently had a heart attack, should take amlodipine with caution.<sup id="cite_ref-amlodipine_nhs.uk_2018_29-0" class="reference"><a href="#cite_note-amlodipine_nhs.uk_2018-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Adverse_effects">Adverse effects</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=4" title="Edit section: Adverse effects"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="mw-default-size" typeof="mw:File/Thumb"><a href="/wiki/File:Amlodipin_Sandoz_bottle.jpg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/d/db/Amlodipin_Sandoz_bottle.jpg/250px-Amlodipin_Sandoz_bottle.jpg" decoding="async" width="170" height="227" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/db/Amlodipin_Sandoz_bottle.jpg/330px-Amlodipin_Sandoz_bottle.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/db/Amlodipin_Sandoz_bottle.jpg/500px-Amlodipin_Sandoz_bottle.jpg 2x" data-file-width="2673" data-file-height="3564" /></a><figcaption>Amlodipin Sandoz, bottle and pills in Sweden</figcaption></figure> <p>Some common dose-dependent adverse effects of amlodipine include vasodilatory effects, <a href="/wiki/Peripheral_edema" title="Peripheral edema">peripheral edema</a>, <a href="/wiki/Dizziness" title="Dizziness">dizziness</a>, <a href="/wiki/Palpitations" title="Palpitations">palpitations</a>, and <a href="/wiki/Flushing_(physiology)" title="Flushing (physiology)">flushing</a>.<sup id="cite_ref-Norvasc_FDA_label_7-6" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> Peripheral edema (fluid accumulation in the tissues) occurs at rate of 10.8% at a 10-mg dose (versus 0.6% for placebos), and is three times more likely in women than in men.<sup id="cite_ref-Norvasc_FDA_label_7-7" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It causes more dilation in the <a href="/wiki/Arterioles" class="mw-redirect" title="Arterioles">arterioles</a> and precapillary vessels than the postcapillary vessels and venules. The increased dilation allows for more blood, which is unable to push through to the relatively constricted postcapillary venules and vessels; the pressure causes much of the plasma to move into the <a href="/wiki/Interstitial_fluid" class="mw-redirect" title="Interstitial fluid">interstitial space</a>.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> Amlodipine-association edema can be avoided by adding ACE inhibitors or angiotensin II receptor antagonist.<sup id="cite_ref-ASHP2016_10-13" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> Of the other dose-dependent side effects, palpitations (4.5% at 10 mg vs. 0.6% in placebos) and flushing (2.6% vs. 0%) occurred more often in women; dizziness (3.4% vs. 1.5%) had no sex bias.<sup id="cite_ref-Norvasc_FDA_label_7-8" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>Common but not dose-related adverse effects are <a href="/wiki/Fatigue_(medical)" class="mw-redirect" title="Fatigue (medical)">fatigue</a> (4.5% vs. 2.8% with a placebo), <a href="/wiki/Nausea" title="Nausea">nausea</a> (2.9% vs. 1.9%), <a href="/wiki/Abdominal_pain" title="Abdominal pain">abdominal pain</a> (1.6% vs. 0.3%), and <a href="/wiki/Somnolence" title="Somnolence">drowsiness</a> (1.4% vs. 0.6%).<sup id="cite_ref-Norvasc_FDA_label_7-9" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Side effects occurring less than 1% of the time include: <a href="/wiki/Blood_disorders" class="mw-redirect" title="Blood disorders">blood disorders</a>, <a href="/wiki/Impotence" class="mw-redirect" title="Impotence">impotence</a>, <a href="/wiki/Clinical_depression" class="mw-redirect" title="Clinical depression">depression</a>, <a href="/wiki/Peripheral_neuropathy" title="Peripheral neuropathy">peripheral neuropathy</a>, <a href="/wiki/Insomnia" title="Insomnia">insomnia</a>, <a href="/wiki/Tachycardia" title="Tachycardia">tachycardia</a>, <a href="/wiki/Gingival_enlargement" title="Gingival enlargement">gingival enlargement</a>, <a href="/wiki/Hepatitis" title="Hepatitis">hepatitis</a>, and <a href="/wiki/Jaundice" title="Jaundice">jaundice</a>.<sup id="cite_ref-Norvasc_FDA_label_7-10" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-32" class="reference"><a href="#cite_note-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-33" class="reference"><a href="#cite_note-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine-associated gingival overgrowth is a relatively common side effect with exposure to amlodipine.<sup id="cite_ref-Ga2018_34-0" class="reference"><a href="#cite_note-Ga2018-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> Poor dental health and buildup of dental plaque are risk factors.<sup id="cite_ref-Ga2018_34-1" class="reference"><a href="#cite_note-Ga2018-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine may increase the risk of worsening <a href="/wiki/Angina" title="Angina">angina</a> or acute myocardial infarction, especially in those with severe <a href="/wiki/Coronary_artery_disease" title="Coronary artery disease">obstructive coronary artery disease</a>, upon dosage initiation or increase. However, depending on the situation, amlodipine inhibits constriction and restores blood flow in coronary arteries as a result of its acting directly on <a href="/wiki/Vascular_smooth_muscle" title="Vascular smooth muscle">vascular smooth muscle</a>, causing a reduction in peripheral <a href="/wiki/Vascular_resistance" title="Vascular resistance">vascular resistance</a> and a consequent reduction in blood pressure.<sup id="cite_ref-ASHP2016_10-14" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Amlodipine and other dihydropyridine calcium channel blockers are associated with <a href="/wiki/Primary_open_angle_glaucoma" class="mw-redirect" title="Primary open angle glaucoma">primary open angle glaucoma</a>.<sup id="cite_ref-35" class="reference"><a href="#cite_note-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Overdose">Overdose</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=5" title="Edit section: Overdose"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1236090951">.mw-parser-output .hatnote{font-style:italic}.mw-parser-output div.hatnote{padding-left:1.6em;margin-bottom:0.5em}.mw-parser-output .hatnote i{font-style:normal}.mw-parser-output .hatnote+link+.hatnote{margin-top:-0.5em}@media print{body.ns-0 .mw-parser-output .hatnote{display:none!important}}</style><div role="note" class="hatnote navigation-not-searchable">See also: <a href="/wiki/Calcium_channel_blocker_toxicity" title="Calcium channel blocker toxicity">Calcium channel blocker toxicity</a></div> <p>Although rare,<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> amlodipine overdose toxicity can result in widening of blood vessels, severe low blood pressure, and fast heart rate.<sup id="cite_ref-Pillay_2013_37-0" class="reference"><a href="#cite_note-Pillay_2013-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> Toxicity is generally managed with <a href="/wiki/Fluid_replacement" title="Fluid replacement">fluid replacement</a><sup id="cite_ref-38" class="reference"><a href="#cite_note-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup> monitoring <a href="/wiki/Electrocardiography" title="Electrocardiography">ECG</a> results, vital signs, respiratory system function, glucose levels, kidney function, electrolyte levels, and urine output. <a href="/wiki/Vasopressor" class="mw-redirect" title="Vasopressor">Vasopressors</a> are also administered when low blood pressure is not alleviated by fluid resuscitation.<sup id="cite_ref-Norvasc_FDA_label_7-11" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Pillay_2013_37-1" class="reference"><a href="#cite_note-Pillay_2013-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=6" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Several drugs interact with amlodipine to increase its levels in the body. CYP3A inhibitors, by nature of inhibiting the enzyme that metabolizes amlodipine, <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>, are one such class of drugs. Others include the calcium-channel blocker <a href="/wiki/Diltiazem" title="Diltiazem">diltiazem</a>, the antibiotic <a href="/wiki/Clarithromycin" title="Clarithromycin">clarithromycin</a>, and possibly some antifungals.<sup id="cite_ref-Norvasc_FDA_label_7-12" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> Amlodipine causes several drugs to increase in levels, including <a href="/wiki/Cyclosporine" class="mw-redirect" title="Cyclosporine">cyclosporine</a>, <a href="/wiki/Simvastatin" title="Simvastatin">simvastatin</a>, and <a href="/wiki/Tacrolimus" title="Tacrolimus">tacrolimus</a> (the increase in the last one being more likely in people with CYP3A5*3 genetic polymorphisms).<sup id="cite_ref-39" class="reference"><a href="#cite_note-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> When more than 20 mg of simvastatin, a <a href="/wiki/Lipid-lowering_agent" title="Lipid-lowering agent">lipid-lowering agent</a>, are given with amlodipine, the risk of <a href="/wiki/Myopathy" title="Myopathy">myopathy</a> increases.<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> The FDA issued a warning to limit simvastatin to a maximum dose of 20 mg if taken with amlodipine based on evidence from the SEARCH trial.<sup id="cite_ref-41" class="reference"><a href="#cite_note-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> Giving amlodipine with <a href="/wiki/Viagra" class="mw-redirect" title="Viagra">Viagra</a> increases the risk of hypotension.<sup id="cite_ref-Norvasc_FDA_label_7-13" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-ASHP2016_10-15" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Pharmacology">Pharmacology</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=7" title="Edit section: Pharmacology"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amlodipine is a long-acting calcium channel antagonist that selectively inhibits calcium ion influx across cell membranes.<sup id="cite_ref-42" class="reference"><a href="#cite_note-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> It targets L-type calcium channels in muscle cells and N-type calcium channels in the central nervous system which are involved in nociceptive signalling and pain perception.<sup id="cite_ref-Amlodipine_43-0" class="reference"><a href="#cite_note-Amlodipine-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-44" class="reference"><a href="#cite_note-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> Amlodipine has an inhibitory effect on calcium influx in smooth muscle cells to inhibit contraction.<sup class="noprint Inline-Template Template-Fact" style="white-space:nowrap;">[<i><a href="/wiki/Wikipedia:Citation_needed" title="Wikipedia:Citation needed"><span title="This claim needs references to reliable sources. (June 2023)">citation needed</span></a></i>]</sup> </p><p>Amlodipine ends up significantly reducing total vascular resistance without decreasing <a href="/wiki/Cardiac_output" title="Cardiac output">cardiac output</a> expressed by pressure-rate product and cardiac contractability in comparison with <a href="/wiki/Verapamil" title="Verapamil">verapamil</a>, a non-dihydropyridine.<sup id="cite_ref-Nazzaro_1995_45-0" class="reference"><a href="#cite_note-Nazzaro_1995-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> In turn, following treatment lasting a month, with amlodipine, cardiac output is significantly enhanced.<sup id="cite_ref-Nazzaro_1995_45-1" class="reference"><a href="#cite_note-Nazzaro_1995-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> Unlike verapamil which has efficacy in moderation of emotional arousal and reduces cardiac load without lowering cardiac output demands, amlodipine increases the cardiac output response concomitantly with increased functional cardiac load.<sup id="cite_ref-Nazzaro_1995_45-2" class="reference"><a href="#cite_note-Nazzaro_1995-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mechanism_of_action">Mechanism of action</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=8" title="Edit section: Mechanism of action"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amlodipine is an angioselective <a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">calcium channel blocker</a> and inhibits the movement of calcium ions into <a href="/wiki/Vascular_smooth_muscle" title="Vascular smooth muscle">vascular smooth muscle</a> cells and <a href="/wiki/Cardiac_muscle_cell" class="mw-redirect" title="Cardiac muscle cell">cardiac muscle cells</a> which inhibits the contraction of cardiac muscle and vascular smooth muscle cells. Amlodipine inhibits calcium ion influx across cell membranes, with a greater effect on vascular smooth muscle cells. This causes vasodilation and a reduction in <a href="/wiki/Peripheral_vascular_resistance" class="mw-redirect" title="Peripheral vascular resistance">peripheral vascular resistance</a>, thus lowering blood pressure. Its effects on cardiac muscle also prevent excessive constriction in the <a href="/wiki/Coronary_arteries" title="Coronary arteries">coronary arteries</a>.<sup id="cite_ref-ASHP2016_10-16" class="reference"><a href="#cite_note-ASHP2016-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p><p>Negative <a href="/wiki/Inotrope" title="Inotrope">inotropic</a> effects can be detected <i>in vitro</i>, but such effects have not been seen in intact animals at therapeutic doses. Among the two <a href="/wiki/Stereoisomerism" title="Stereoisomerism">stereoisomers</a> [<i>R</i>(+), <i>S</i>(–)], the (–) isomer has been reported to be more active than the (+) isomer.<sup id="cite_ref-J.R._Karmokeretal.2016_46-0" class="reference"><a href="#cite_note-J.R._Karmokeretal.2016-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> Serum calcium concentration is not affected by amlodipine. And it specifically inhibits the currents of <a href="/wiki/L-type_calcium_channel" title="L-type calcium channel"><small>L</small>-type</a> <a href="/wiki/Cav1.3" title="Cav1.3">Cav1.3</a> channels in the <a href="/wiki/Zona_glomerulosa" title="Zona glomerulosa">zona glomerulosa</a> of the <a href="/wiki/Adrenal_gland" title="Adrenal gland">adrenal gland</a>.<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-48" class="reference"><a href="#cite_note-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p><p>The mechanisms by which amlodipine relieves angina are: </p> <ul><li><a href="/wiki/Stable_angina" class="mw-redirect" title="Stable angina">Stable angina</a>: amlodipine reduces the total peripheral resistance (afterload) against which the heart works and reduces the <a href="/wiki/Rate_pressure_product" title="Rate pressure product">rate pressure product</a>, thereby lowering myocardial oxygen demand, at any given level of exercise.<sup id="cite_ref-49" class="reference"><a href="#cite_note-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Prinzmetal%27s_angina" class="mw-redirect" title="Prinzmetal's angina">Variant angina</a>: amlodipine blocks <a href="/wiki/Vasospasm" title="Vasospasm">spasm of the coronary arteries</a> and restores blood flow in coronary arteries and arterioles in response to calcium, potassium, <a href="/wiki/Epinephrine" class="mw-redirect" title="Epinephrine">epinephrine</a>, <a href="/wiki/Serotonin" title="Serotonin">serotonin</a>, and <a href="/wiki/Thromboxane_A2" title="Thromboxane A2">thromboxane A2</a> analog in experimental animal models and in human coronary vessels <i>in vitro</i>.<sup id="cite_ref-50" class="reference"><a href="#cite_note-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup></li></ul> <p>Amlodipine has additionally been found to act as an <a href="/wiki/Receptor_antagonist" title="Receptor antagonist">antagonist</a> of the <a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">mineralocorticoid receptor</a>, or as an <a href="/wiki/Antimineralocorticoid" class="mw-redirect" title="Antimineralocorticoid">antimineralocorticoid</a>.<sup id="cite_ref-Luther2014_51-0" class="reference"><a href="#cite_note-Luther2014-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Pharmacokinetics">Pharmacokinetics</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=9" title="Edit section: Pharmacokinetics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <figure class="skin-invert-image" typeof="mw:File/Frame"><a href="/wiki/File:Amlodipine_and_major_metabolite.svg" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Amlodipine_and_major_metabolite.svg/302px-Amlodipine_and_major_metabolite.svg.png" decoding="async" width="302" height="106" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Amlodipine_and_major_metabolite.svg/453px-Amlodipine_and_major_metabolite.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/1f/Amlodipine_and_major_metabolite.svg/604px-Amlodipine_and_major_metabolite.svg.png 2x" data-file-width="302" data-file-height="106" /></a><figcaption>Amlodipine and one of its major metabolites: The nitrogen-containing ring is oxidized, and two of the side chains are hydrolyzed.<sup id="cite_ref-52" class="reference"><a href="#cite_note-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup></figcaption></figure> <p>Amlodipine has been studied in healthy volunteers following oral administration of <sup>14</sup>C-labelled drug.<sup id="cite_ref-pmid2967593_53-0" class="reference"><a href="#cite_note-pmid2967593-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup> Amlodipine is well absorbed by the oral route with a mean oral <a href="/wiki/Bioavailability" title="Bioavailability">bioavailability</a> around 60%; the half-life of amlodipine is about 30 h to 50 h, and steady-state plasma concentrations are achieved after 7 to 8 days of daily dosing.<sup id="cite_ref-Norvasc_FDA_label_7-14" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> In the blood it has high plasma protein binding of 97.5%.<sup id="cite_ref-Amlodipine_43-1" class="reference"><a href="#cite_note-Amlodipine-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup> Its long half-life and high bioavailability are largely in part of its high pKa (8.6); it is ionized at physiological pH, and thus can strongly attract proteins.<sup id="cite_ref-Norvasc_FDA_label_7-15" class="reference"><a href="#cite_note-Norvasc_FDA_label-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> It is slowly metabolized in the liver by <a href="/wiki/CYP3A4" title="CYP3A4">CYP3A4</a>, with its <a href="/wiki/Amine_group" class="mw-redirect" title="Amine group">amine group</a> being oxidized and its side <a href="/wiki/Ester" title="Ester">ester</a> chain being <a href="/wiki/Hydrolyzed" class="mw-redirect" title="Hydrolyzed">hydrolyzed</a>, resulting in an inactive <a href="/wiki/Pyridine" title="Pyridine">pyridine</a> metabolite.<sup id="cite_ref-54" class="reference"><a href="#cite_note-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup> Renal elimination is the major route of excretion with about 60% of an administered dose recovered in urine, largely as inactive pyridine metabolites. However, renal impairment does not significantly influence amlodipine elimination.<sup id="cite_ref-55" class="reference"><a href="#cite_note-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> 20-25% of the drug is excreted in the faeces.<sup id="cite_ref-56" class="reference"><a href="#cite_note-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="History">History</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=10" title="Edit section: History"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><a href="/wiki/Pfizer" title="Pfizer">Pfizer</a>'s <a href="/wiki/Patent" title="Patent">patent</a> protection on Norvasc lasted until 2007; total patent expiration occurred later in 2007.<sup id="cite_ref-57" class="reference"><a href="#cite_note-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup> A number of generic versions are available. In the United Kingdom, tablets of amlodipine from different suppliers may contain different salts. The strength of the tablets is expressed in terms of amlodipine base, i.e., without the salts. Tablets containing different salts are therefore considered interchangeable. A fixed-dose combination of amlodipine and <a href="/wiki/Perindopril" title="Perindopril">perindopril</a>, an <a href="/wiki/Angiotensin_converting_enzyme" class="mw-redirect" title="Angiotensin converting enzyme">angiotensin converting enzyme</a> inhibitor is also available.<sup id="cite_ref-58" class="reference"><a href="#cite_note-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup> </p><p>The medical form comes as <a href="/wiki/Besilate" class="mw-redirect" title="Besilate">besilate</a>, <a href="/wiki/Mesylate" title="Mesylate">mesylate</a>, or <a href="/wiki/Maleate" class="mw-redirect" title="Maleate">maleate</a>.<sup id="cite_ref-59" class="reference"><a href="#cite_note-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Society_and_culture">Society and culture</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=11" title="Edit section: Society and culture"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Brand_names">Brand names</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=12" title="Edit section: Brand names"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>In the US, Norvasc is marketed by <a href="/wiki/Viatris" title="Viatris">Viatris</a> after Upjohn was spun off from Pfizer.<sup id="cite_ref-60" class="reference"><a href="#cite_note-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-61" class="reference"><a href="#cite_note-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Veterinary_use">Veterinary use</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=13" title="Edit section: Veterinary use"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amlodipine is most often used to treat systemic <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> in both cats and dogs.<sup id="cite_ref-papich_62-0" class="reference"><a href="#cite_note-papich-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup> In cats, it is the first line of treatment due to its efficacy and few side effects.<sup id="cite_ref-63" class="reference"><a href="#cite_note-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup> Systemic <a href="/wiki/Hypertension" title="Hypertension">hypertension</a> in cats is usually secondary to another abnormality, such as <a href="/wiki/Chronic_kidney_disease" title="Chronic kidney disease">chronic kidney disease</a>, and so amlodipine is most often administered to cats with <a href="/wiki/Kidney_disease" title="Kidney disease">kidney disease</a>.<sup id="cite_ref-diamondback_64-0" class="reference"><a href="#cite_note-diamondback-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup> While amlodipine is used in dogs with systemic hypertension, it is not as efficacious. Amlodipine is also used to treat <a href="/wiki/Congestive_heart_failure" class="mw-redirect" title="Congestive heart failure">congestive heart failure</a> due to <a href="/wiki/Mitral_valve_regurgitation" class="mw-redirect" title="Mitral valve regurgitation">mitral valve regurgitation</a> in dogs.<sup id="cite_ref-65" class="reference"><a href="#cite_note-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup> By decreasing resistance to forward flow in the systemic circulation it results in a decrease in regurgitant flow into the <a href="/wiki/Left_atrium" class="mw-redirect" title="Left atrium">left atrium</a>.<sup id="cite_ref-66" class="reference"><a href="#cite_note-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup> Similarly, it can be used on dogs and cats with left-to-right shunting lesions such as <a href="/wiki/Ventricular_septal_defect" title="Ventricular septal defect">ventricular septal defect</a> to reduce the shunt. Side effects are rare in cats. In dogs, the primary side effect is <a href="/wiki/Gingival_hyperplasia" class="mw-redirect" title="Gingival hyperplasia">gingival hyperplasia</a>.<sup id="cite_ref-wedgewood_67-0" class="reference"><a href="#cite_note-wedgewood-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=Amlodipine&action=edit&section=14" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-1"><span class="mw-cite-backlink"><b><a href="#cite_ref-1">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.merriam-webster.com/medical/amlodipine">"Medical Definition of Amlodipine"</a>. <i>www.merriam-webster.com</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20161108030935/http://www.merriam-webster.com/medical/amlodipine">Archived</a> from the original on 8 November 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">5 July</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.merriam-webster.com&rft.atitle=Medical+Definition+of+Amlodipine&rft_id=https%3A%2F%2Fwww.merriam-webster.com%2Fmedical%2Famlodipine&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Drugs.com_pregnancy-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-Drugs.com_pregnancy_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Drugs.com_pregnancy_2-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/pregnancy/amlodipine.html">"Amlodipine Use During Pregnancy"</a>. <i>Drugs.com</i>. 28 October 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20191228022204/https://www.drugs.com/pregnancy/amlodipine.html">Archived</a> from the original on 28 December 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">29 December</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Amlodipine+Use+During+Pregnancy&rft.date=2019-10-28&rft_id=https%3A%2F%2Fwww.drugs.com%2Fpregnancy%2Famlodipine.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.legislation.gov.au/Details/F2017L00605">"Poisons Standard June 2017"</a>. <i>legislation.gov.au</i>. 29 May 2017. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20201213060305/https://www.legislation.gov.au/Details/F2017L00605/">Archived</a> from the original on 13 December 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">7 January</span> 2018</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=legislation.gov.au&rft.atitle=Poisons+Standard+June+2017&rft.date=2017-05-29&rft_id=https%3A%2F%2Fwww.legislation.gov.au%2FDetails%2FF2017L00605&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent&id=CP-2021-PI-01265-1">"Norvasc Product and Consumer Medicine Information Licence"</a>. <i>TGA eBS</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220620034909/https://www.ebs.tga.gov.au/ebs/picmi/picmirepository.nsf/pdf?OpenAgent=&id=CP-2021-PI-01265-1">Archived</a> from the original on 20 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">19 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=TGA+eBS&rft.atitle=Norvasc+Product+and+Consumer+Medicine+Information+Licence&rft_id=https%3A%2F%2Fwww.ebs.tga.gov.au%2Febs%2Fpicmi%2Fpicmirepository.nsf%2Fpdf%3FOpenAgent%26id%3DCP-2021-PI-01265-1&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=12938">"Norvasc product information"</a>. <i><a href="/wiki/Health_Canada" title="Health Canada">Health Canada</a></i>. 25 April 2012. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220620034859/https://health-products.canada.ca/dpd-bdpp/info.do?lang=en&code=12938">Archived</a> from the original on 20 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">19 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Health+Canada&rft.atitle=Norvasc+product+information&rft.date=2012-04-25&rft_id=https%3A%2F%2Fhealth-products.canada.ca%2Fdpd-bdpp%2Finfo.do%3Flang%3Den%26code%3D12938&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Istin_SmPC-6"><span class="mw-cite-backlink">^ <a href="#cite_ref-Istin_SmPC_6-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Istin_SmPC_6-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Istin_SmPC_6-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.medicines.org.uk/emc/product/1069/smpc">"Istin 5 mg Tablets - Summary of Product Characteristics (SmPC)"</a>. <i>(emc)</i>. 28 September 2020. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220620032313/https://www.medicines.org.uk/emc/product/1069/smpc">Archived</a> from the original on 20 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">19 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=%28emc%29&rft.atitle=Istin+5+mg+Tablets+-+Summary+of+Product+Characteristics+%28SmPC%29&rft.date=2020-09-28&rft_id=https%3A%2F%2Fwww.medicines.org.uk%2Femc%2Fproduct%2F1069%2Fsmpc&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Norvasc_FDA_label-7"><span class="mw-cite-backlink">^ <a href="#cite_ref-Norvasc_FDA_label_7-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-Norvasc_FDA_label_7-15"><sup><i><b>p</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abd6a2ca-40c2-485c-bc53-db1c652505ed">"Norvasc- amlodipine besylate tablet"</a>. <i>DailyMed</i>. 14 March 2019. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20200610221323/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=abd6a2ca-40c2-485c-bc53-db1c652505ed">Archived</a> from the original on 10 June 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">29 December</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Norvasc-+amlodipine+besylate+tablet&rft.date=2019-03-14&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Dabd6a2ca-40c2-485c-bc53-db1c652505ed&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Norliqva_FDA_label-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-Norliqva_FDA_label_8-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c1730a51-4383-4c61-a9a1-7e1326bd0abe">"Norliqva- amlodipine solution"</a>. <i>DailyMed</i>. 28 February 2022. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220620032433/https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=c1730a51-4383-4c61-a9a1-7e1326bd0abe">Archived</a> from the original on 20 June 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">19 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=DailyMed&rft.atitle=Norliqva-+amlodipine+solution&rft.date=2022-02-28&rft_id=https%3A%2F%2Fdailymed.nlm.nih.gov%2Fdailymed%2FdrugInfo.cfm%3Fsetid%3Dc1730a51-4383-4c61-a9a1-7e1326bd0abe&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-9"><span class="mw-cite-backlink"><b><a href="#cite_ref-9">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ema.europa.eu/en/documents/psusa/amlodipine-list-nationally-authorised-medicinal-products-psusa/00000174/201703_en.pdf">"Amlodipine"</a> <span class="cs1-format">(PDF)</span>. <i>List of nationally authorised medicinal products</i>. European Medicines Agency. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20220303093553/https://www.ema.europa.eu/en/documents/psusa/amlodipine-list-nationally-authorised-medicinal-products-psusa/00000174/201703_en.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 3 March 2022<span class="reference-accessdate">. Retrieved <span class="nowrap">20 June</span> 2022</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=List+of+nationally+authorised+medicinal+products&rft.atitle=Amlodipine&rft_id=https%3A%2F%2Fwww.ema.europa.eu%2Fen%2Fdocuments%2Fpsusa%2Famlodipine-list-nationally-authorised-medicinal-products-psusa%2F00000174%2F201703_en.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-ASHP2016-10"><span class="mw-cite-backlink">^ <a href="#cite_ref-ASHP2016_10-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-4"><sup><i><b>e</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-5"><sup><i><b>f</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-6"><sup><i><b>g</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-7"><sup><i><b>h</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-8"><sup><i><b>i</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-9"><sup><i><b>j</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-10"><sup><i><b>k</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-11"><sup><i><b>l</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-12"><sup><i><b>m</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-13"><sup><i><b>n</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-14"><sup><i><b>o</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-15"><sup><i><b>p</b></i></sup></a> <a href="#cite_ref-ASHP2016_10-16"><sup><i><b>q</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/monograph/amlodipine-besylate.html">"Amlodipine Besylate"</a>. <i>Drugs.com</i>. American Society of Hospital Pharmacists. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160604161825/http://www.drugs.com/monograph/amlodipine-besylate.html">Archived</a> from the original on 4 June 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">22 July</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Amlodipine+Besylate&rft_id=https%3A%2F%2Fwww.drugs.com%2Fmonograph%2Famlodipine-besylate.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Goldmancecil-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-Goldmancecil_11-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBoden2012" class="citation book cs1">Boden WE (2012). <a rel="nofollow" class="external text" href="https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/variant-angina-pectoris"><i>Goldman's Cecil Medicine</i></a> (24th ed.). Saunders. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4377-1604-7" title="Special:BookSources/978-1-4377-1604-7"><bdi>978-1-4377-1604-7</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230826150455/https://www.sciencedirect.com/topics/pharmacology-toxicology-and-pharmaceutical-science/variant-angina-pectoris">Archived</a> from the original on 26 August 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">26 August</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Goldman%27s+Cecil+Medicine&rft.edition=24th&rft.pub=Saunders&rft.date=2012&rft.isbn=978-1-4377-1604-7&rft.aulast=Boden&rft.aufirst=WE&rft_id=https%3A%2F%2Fwww.sciencedirect.com%2Ftopics%2Fpharmacology-toxicology-and-pharmaceutical-science%2Fvariant-angina-pectoris&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFFischerGanellin2006" class="citation book cs1">Fischer J, Ganellin CR (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA465"><i>Analogue-based Drug Discovery</i></a>. John Wiley & Sons. p. 465. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783527607495" title="Special:BookSources/9783527607495"><bdi>9783527607495</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210827213813/https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA465">Archived</a> from the original on 27 August 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">1 June</span> 2020</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Analogue-based+Drug+Discovery&rft.pages=465&rft.pub=John+Wiley+%26+Sons&rft.date=2006&rft.isbn=9783527607495&rft.aulast=Fischer&rft.aufirst=J&rft.au=Ganellin%2C+CR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DFjKfqkaKkAAC%26pg%3DPA465&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-WHO23rd-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-WHO23rd_13-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWorld_Health_Organization2023" class="citation book cs1"><a href="/wiki/World_Health_Organization" title="World Health Organization">World Health Organization</a> (2023). <i>The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)</i>. Geneva: World Health Organization. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/10665%2F371090">10665/371090</a></span>. WHO/MHP/HPS/EML/2023.02.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+selection+and+use+of+essential+medicines+2023%3A+web+annex+A%3A+World+Health+Organization+model+list+of+essential+medicines%3A+23rd+list+%282023%29&rft.place=Geneva&rft.pub=World+Health+Organization&rft.date=2023&rft_id=info%3Ahdl%2F10665%2F371090&rft.au=World+Health+Organization&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals">"Competitive Generic Therapy Approvals"</a>. <i>U.S. <a href="/wiki/Food_and_Drug_Administration" title="Food and Drug Administration">Food and Drug Administration</a> (FDA)</i>. 29 June 2023. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20230629233651/https://www.fda.gov/drugs/generic-drugs/competitive-generic-therapy-approvals">Archived</a> from the original on 29 June 2023<span class="reference-accessdate">. Retrieved <span class="nowrap">29 June</span> 2023</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=U.S.+Food+and+Drug+Administration+%28FDA%29&rft.atitle=Competitive+Generic+Therapy+Approvals&rft.date=2023-06-29&rft_id=https%3A%2F%2Fwww.fda.gov%2Fdrugs%2Fgeneric-drugs%2Fcompetitive-generic-therapy-approvals&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-15">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Top300Drugs.aspx">"The Top 300 of 2022"</a>. <i>ClinCalc</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20240830202410/https://clincalc.com/DrugStats/Top300Drugs.aspx">Archived</a> from the original on 30 August 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=The+Top+300+of+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FTop300Drugs.aspx&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-16">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://clincalc.com/DrugStats/Drugs/Amlodipine">"Amlodipine Drug Usage Statistics, United States, 2013 - 2022"</a>. <i>ClinCalc</i><span class="reference-accessdate">. Retrieved <span class="nowrap">30 August</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=ClinCalc&rft.atitle=Amlodipine+Drug+Usage+Statistics%2C+United+States%2C+2013+-+2022&rft_id=https%3A%2F%2Fclincalc.com%2FDrugStats%2FDrugs%2FAmlodipine&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-17">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.aihw.gov.au/reports/medicines/medicines-in-the-health-system">"Medicines in the health system"</a>. <i>Australian Institute of Health and Welfare</i>. 2 July 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">30 September</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Australian+Institute+of+Health+and+Welfare&rft.atitle=Medicines+in+the+health+system&rft.date=2024-07-02&rft_id=https%3A%2F%2Fwww.aihw.gov.au%2Freports%2Fmedicines%2Fmedicines-in-the-health-system&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-18">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWang2009" class="citation journal cs1">Wang JG (2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725792">"A combined role of calcium channel blockers and angiotensin receptor blockers in stroke prevention"</a>. <i>Vascular Health and Risk Management</i>. <b>5</b>: <span class="nowrap">593–</span>605. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2147%2Fvhrm.s6203">10.2147/vhrm.s6203</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2725792">2725792</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19688100">19688100</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Vascular+Health+and+Risk+Management&rft.atitle=A+combined+role+of+calcium+channel+blockers+and+angiotensin+receptor+blockers+in+stroke+prevention&rft.volume=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E593-%3C%2Fspan%3E605&rft.date=2009&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2725792%23id-name%3DPMC&rft_id=info%3Apmid%2F19688100&rft_id=info%3Adoi%2F10.2147%2Fvhrm.s6203&rft.aulast=Wang&rft.aufirst=JG&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2725792&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><i><a href="/wiki/MedlinePlus" title="MedlinePlus">MedlinePlus Encyclopedia</a></i>: <a rel="nofollow" class="external text" href="https://medlineplus.gov/ency/article/000198.htm">Stable angina</a></span> </li> <li id="cite_note-Chen_2013-20"><span class="mw-cite-backlink">^ <a href="#cite_ref-Chen_2013_20-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Chen_2013_20-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFChenYang2013" class="citation journal cs1">Chen GJ, Yang MS (6 March 2013). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590278">"The effects of calcium channel blockers in the prevention of stroke in adults with hypertension: a meta-analysis of data from 273,543 participants in 31 randomized controlled trials"</a>. <i>PLOS ONE</i>. <b>8</b> (3): e57854. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2013PLoSO...857854C">2013PLoSO...857854C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1371%2Fjournal.pone.0057854">10.1371/journal.pone.0057854</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590278">3590278</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23483932">23483932</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=PLOS+ONE&rft.atitle=The+effects+of+calcium+channel+blockers+in+the+prevention+of+stroke+in+adults+with+hypertension%3A+a+meta-analysis+of+data+from+273%2C543+participants+in+31+randomized+controlled+trials&rft.volume=8&rft.issue=3&rft.pages=e57854&rft.date=2013-03-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3590278%23id-name%3DPMC&rft_id=info%3Apmid%2F23483932&rft_id=info%3Adoi%2F10.1371%2Fjournal.pone.0057854&rft_id=info%3Abibcode%2F2013PLoSO...857854C&rft.aulast=Chen&rft.aufirst=GJ&rft.au=Yang%2C+MS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3590278&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Mukete_2015-21"><span class="mw-cite-backlink">^ <a href="#cite_ref-Mukete_2015_21-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Mukete_2015_21-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMuketeCassidyFerdinandLe_Jemtel2015" class="citation journal cs1">Mukete BN, Cassidy M, Ferdinand KC, Le Jemtel TH (August 2015). "Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-Analysis". <i>American Journal of Cardiovascular Drugs</i>. <b>15</b> (4): <span class="nowrap">243–</span>257. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40256-015-0129-0">10.1007/s40256-015-0129-0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26055616">26055616</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:33792903">33792903</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Journal+of+Cardiovascular+Drugs&rft.atitle=Long-Term+Anti-Hypertensive+Therapy+and+Stroke+Prevention%3A+A+Meta-Analysis&rft.volume=15&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E243-%3C%2Fspan%3E257&rft.date=2015-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A33792903%23id-name%3DS2CID&rft_id=info%3Apmid%2F26055616&rft_id=info%3Adoi%2F10.1007%2Fs40256-015-0129-0&rft.aulast=Mukete&rft.aufirst=BN&rft.au=Cassidy%2C+M&rft.au=Ferdinand%2C+KC&rft.au=Le+Jemtel%2C+TH&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Iyengar_2021-22"><span class="mw-cite-backlink">^ <a href="#cite_ref-Iyengar_2021_22-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Iyengar_2021_22-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFIyengarMohanRayRao2021" class="citation journal cs1">Iyengar SS, Mohan JC, Ray S, Rao MS, Khan MY, Patted UR, et al. (December 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555097">"Effect of Amlodipine in Stroke and Myocardial infarction: A Systematic Review and Meta-analysis"</a>. <i>Cardiology and Therapy</i>. <b>10</b> (2): <span class="nowrap">429–</span>444. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs40119-021-00239-1">10.1007/s40119-021-00239-1</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8555097">8555097</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34480745">34480745</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cardiology+and+Therapy&rft.atitle=Effect+of+Amlodipine+in+Stroke+and+Myocardial+infarction%3A+A+Systematic+Review+and+Meta-analysis&rft.volume=10&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E429-%3C%2Fspan%3E444&rft.date=2021-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8555097%23id-name%3DPMC&rft_id=info%3Apmid%2F34480745&rft_id=info%3Adoi%2F10.1007%2Fs40119-021-00239-1&rft.aulast=Iyengar&rft.aufirst=SS&rft.au=Mohan%2C+JC&rft.au=Ray%2C+S&rft.au=Rao%2C+MS&rft.au=Khan%2C+MY&rft.au=Patted%2C+UR&rft.au=Gaurav%2C+K&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8555097&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Baumhäkel_Böhm_pp._207–214-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-Baumhäkel_Böhm_pp._207–214_23-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBaumhäkelBöhm2010" class="citation journal cs1">Baumhäkel M, Böhm M (April 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856576">"Recent achievements in the management of Raynaud's phenomenon"</a>. <i>Vascular Health and Risk Management</i>. <b>6</b>: <span class="nowrap">207–</span>214. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2147%2Fvhrm.s5255">10.2147/vhrm.s5255</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856576">2856576</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/20407628">20407628</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Vascular+Health+and+Risk+Management&rft.atitle=Recent+achievements+in+the+management+of+Raynaud%27s+phenomenon&rft.volume=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E207-%3C%2Fspan%3E214&rft.date=2010-04&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2856576%23id-name%3DPMC&rft_id=info%3Apmid%2F20407628&rft_id=info%3Adoi%2F10.2147%2Fvhrm.s5255&rft.aulast=Baumh%C3%A4kel&rft.aufirst=M&rft.au=B%C3%B6hm%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2856576&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-n686-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-n686_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMusaQurie2024" class="citation book cs1">Musa R, Qurie A (2024). "Raynaud Disease". <i>StatPearls</i>. Treasure Island (FL): StatPearls Publishing. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29763008">29763008</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Raynaud+Disease&rft.btitle=StatPearls&rft.place=Treasure+Island+%28FL%29&rft.pub=StatPearls+Publishing&rft.date=2024&rft_id=info%3Apmid%2F29763008&rft.aulast=Musa&rft.aufirst=R&rft.au=Qurie%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-25">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFDelgado-MonteroZamorano2012" class="citation journal cs1">Delgado-Montero A, Zamorano JL (December 2012). "Atorvastatin calcium plus amlodipine for the treatment of hypertension". <i>Expert Opinion on Pharmacotherapy</i>. <b>13</b> (18): <span class="nowrap">2673–</span>2685. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1517%2F14656566.2012.742064">10.1517/14656566.2012.742064</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23140185">23140185</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:43250258">43250258</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Opinion+on+Pharmacotherapy&rft.atitle=Atorvastatin+calcium+plus+amlodipine+for+the+treatment+of+hypertension&rft.volume=13&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2673-%3C%2Fspan%3E2685&rft.date=2012-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A43250258%23id-name%3DS2CID&rft_id=info%3Apmid%2F23140185&rft_id=info%3Adoi%2F10.1517%2F14656566.2012.742064&rft.aulast=Delgado-Montero&rft.aufirst=A&rft.au=Zamorano%2C+JL&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span><span style="position:relative; top: -2px;"><span typeof="mw:File"><a href="/wiki/Paywall" title="closed access publication – behind paywall"><img alt="Closed access icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/9px-Closed_Access_logo_transparent.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/14px-Closed_Access_logo_transparent.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/18px-Closed_Access_logo_transparent.svg.png 2x" data-file-width="640" data-file-height="1000" /></a></span></span></span> </li> <li id="cite_note-diseaseinter-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-diseaseinter_26-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugs.com/disease-interactions/amlodipine.html">"Amlodipine Disease Interactions"</a>. <i>Drugs.com</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170811011628/https://www.drugs.com/disease-interactions/amlodipine.html">Archived</a> from the original on 11 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">4 July</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drugs.com&rft.atitle=Amlodipine+Disease+Interactions&rft_id=https%3A%2F%2Fwww.drugs.com%2Fdisease-interactions%2Famlodipine.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-27">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGrimardSaffordBurns2016" class="citation journal cs1">Grimard BH, Safford RE, Burns EL (March 2016). <a rel="nofollow" class="external text" href="http://www.aafp.org/afp/2016/0301/p371.html">"Aortic Stenosis: Diagnosis and Treatment"</a>. <i>American Family Physician</i>. <b>93</b> (5): <span class="nowrap">371–</span>378. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26926974">26926974</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170811010658/http://www.aafp.org/afp/2016/0301/p371.html">Archived</a> from the original on 11 August 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=American+Family+Physician&rft.atitle=Aortic+Stenosis%3A+Diagnosis+and+Treatment&rft.volume=93&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E371-%3C%2Fspan%3E378&rft.date=2016-03&rft_id=info%3Apmid%2F26926974&rft.aulast=Grimard&rft.aufirst=BH&rft.au=Safford%2C+RE&rft.au=Burns%2C+EL&rft_id=http%3A%2F%2Fwww.aafp.org%2Fafp%2F2016%2F0301%2Fp371.html&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-hitchings-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-hitchings_28-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHitchingsLonsdaleBurrageBaker2014" class="citation book cs1">Hitchings A, Lonsdale D, Burrage D, Baker E (2014). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=oeYjAwAAQBAJ&pg=PA90"><i>The Top 100 Drugs e-book: Clinical Pharmacology and Practical Prescribing</i></a>. Elsevier Health Sciences. p. 90. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780702055157" title="Special:BookSources/9780702055157"><bdi>9780702055157</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=oeYjAwAAQBAJ&pg=PA90">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=The+Top+100+Drugs+e-book%3A+Clinical+Pharmacology+and+Practical+Prescribing&rft.pages=90&rft.pub=Elsevier+Health+Sciences&rft.date=2014&rft.isbn=9780702055157&rft.aulast=Hitchings&rft.aufirst=A&rft.au=Lonsdale%2C+D&rft.au=Burrage%2C+D&rft.au=Baker%2C+E&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DoeYjAwAAQBAJ%26pg%3DPA90&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-amlodipine_nhs.uk_2018-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-amlodipine_nhs.uk_2018_29-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.nhs.uk/medicines/amlodipine/">"Amlodipine: medicine to treat high blood pressure"</a>. <i>nhs.uk</i>. 29 August 2018. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190209180234/https://www.nhs.uk/medicines/amlodipine/">Archived</a> from the original on 9 February 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">7 February</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=nhs.uk&rft.atitle=Amlodipine%3A+medicine+to+treat+high+blood+pressure&rft.date=2018-08-29&rft_id=https%3A%2F%2Fwww.nhs.uk%2Fmedicines%2Famlodipine%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRussell1988" class="citation journal cs1">Russell RP (March 1988). <a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.HYP.11.3_Pt_2.II42">"Side effects of calcium channel blockers"</a>. <i>Hypertension</i>. <b>11</b> (3 Pt 2): <span class="nowrap">II42 –</span> <span class="nowrap">II44</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1161%2F01.HYP.11.3_Pt_2.II42">10.1161/01.HYP.11.3_Pt_2.II42</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3280492">3280492</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Hypertension&rft.atitle=Side+effects+of+calcium+channel+blockers&rft.volume=11&rft.issue=3+Pt+2&rft.pages=%3Cspan+class%3D%22nowrap%22%3EII42+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3EII44%3C%2Fspan%3E&rft.date=1988-03&rft_id=info%3Adoi%2F10.1161%2F01.HYP.11.3_Pt_2.II42&rft_id=info%3Apmid%2F3280492&rft.aulast=Russell&rft.aufirst=RP&rft_id=https%3A%2F%2Fdoi.org%2F10.1161%252F01.HYP.11.3_Pt_2.II42&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-31">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSica2003" class="citation journal cs1">Sica D (1 July 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1524-6175.2003.02402.x">"Calcium channel blocker-related periperal edema: can it be resolved?"</a>. <i>Journal of Clinical Hypertension</i>. <b>5</b> (4): <span class="nowrap">291–</span>4, 297. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1524-6175.2003.02402.x">10.1111/j.1524-6175.2003.02402.x</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8099365">8099365</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12939574">12939574</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:38027134">38027134</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Hypertension&rft.atitle=Calcium+channel+blocker-related+periperal+edema%3A+can+it+be+resolved%3F&rft.volume=5&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E291-%3C%2Fspan%3E4%2C+297&rft.date=2003-07-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8099365%23id-name%3DPMC&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A38027134%23id-name%3DS2CID&rft_id=info%3Apmid%2F12939574&rft_id=info%3Adoi%2F10.1111%2Fj.1524-6175.2003.02402.x&rft.aulast=Sica&rft.aufirst=D&rft_id=https%3A%2F%2Fdoi.org%2F10.1111%252Fj.1524-6175.2003.02402.x&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-32"><span class="mw-cite-backlink"><b><a href="#cite_ref-32">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMunozVetterlyRotherDa_Cruz2007" class="citation book cs1">Munoz R, Vetterly CG, Rother SJ, Da Cruz EM (18 October 2007). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=NiTR3Uzp_jMC&pg=PA96"><i>Handbook of Pediatric Cardiovascular Drugs</i></a>. Springer Science & Business Media. p. 96. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781846289538" title="Special:BookSources/9781846289538"><bdi>9781846289538</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=NiTR3Uzp_jMC&pg=PA96">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Handbook+of+Pediatric+Cardiovascular+Drugs&rft.pages=96&rft.pub=Springer+Science+%26+Business+Media&rft.date=2007-10-18&rft.isbn=9781846289538&rft.aulast=Munoz&rft.aufirst=R&rft.au=Vetterly%2C+CG&rft.au=Rother%2C+SJ&rft.au=Da+Cruz%2C+EM&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DNiTR3Uzp_jMC%26pg%3DPA96&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-33">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFOnoTanakaTakeuchiMatsumoto2010" class="citation journal cs1">Ono M, Tanaka S, Takeuchi R, Matsumoto H, Okada H, Yamamoto H, et al. (2010). <a rel="nofollow" class="external text" href="https://doi.org/10.5466%2Fijoms.9.96">"Prevalence of Amlodipine-induced Gingival Overgrowth"</a>. <i>International Journal of Oral-Medical Sciences</i>. <b>9</b> (2): <span class="nowrap">96–</span>100. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.5466%2Fijoms.9.96">10.5466/ijoms.9.96</a></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Oral-Medical+Sciences&rft.atitle=Prevalence+of+Amlodipine-induced+Gingival+Overgrowth&rft.volume=9&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E96-%3C%2Fspan%3E100&rft.date=2010&rft_id=info%3Adoi%2F10.5466%2Fijoms.9.96&rft.aulast=Ono&rft.aufirst=M&rft.au=Tanaka%2C+S&rft.au=Takeuchi%2C+R&rft.au=Matsumoto%2C+H&rft.au=Okada%2C+H&rft.au=Yamamoto%2C+H&rft.au=Makiyama%2C+Y&rft.au=Hirayama%2C+T&rft.au=Sakamaki%2C+T&rft.au=Fujii%2C+A&rft.au=Akimoto%2C+Y&rft_id=https%3A%2F%2Fdoi.org%2F10.5466%252Fijoms.9.96&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Ga2018-34"><span class="mw-cite-backlink">^ <a href="#cite_ref-Ga2018_34-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Ga2018_34-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGaurAgnihotri2018" class="citation journal cs1">Gaur S, Agnihotri R (June 2018). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005094">"Is dental plaque the only etiological factor in Amlodipine induced gingival overgrowth? A systematic review of evidence"</a>. <i>Journal of Clinical and Experimental Dentistry</i>. <b>10</b> (6): <span class="nowrap">e610 –</span> <span class="nowrap">e619</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4317%2Fjced.54715">10.4317/jced.54715</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005094">6005094</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29930781">29930781</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+and+Experimental+Dentistry&rft.atitle=Is+dental+plaque+the+only+etiological+factor+in+Amlodipine+induced+gingival+overgrowth%3F+A+systematic+review+of+evidence&rft.volume=10&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3Ee610+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3Ee619%3C%2Fspan%3E&rft.date=2018-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6005094%23id-name%3DPMC&rft_id=info%3Apmid%2F29930781&rft_id=info%3Adoi%2F10.4317%2Fjced.54715&rft.aulast=Gaur&rft.aufirst=S&rft.au=Agnihotri%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6005094&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-35">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKastnerStuartMontesanoDe_Moraes2023" class="citation journal cs1">Kastner A, Stuart KV, Montesano G, De Moraes CG, Kang JH, Wiggs JL, et al. (October 2023). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485742">"Calcium Channel Blocker Use and Associated Glaucoma and Related Traits Among UK Biobank Participants"</a>. <i>JAMA Ophthalmology</i>. <b>141</b> (10): <span class="nowrap">956–</span>964. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1001%2Fjamaophthalmol.2023.3877">10.1001/jamaophthalmol.2023.3877</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10485742">10485742</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/37676684">37676684</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=JAMA+Ophthalmology&rft.atitle=Calcium+Channel+Blocker+Use+and+Associated+Glaucoma+and+Related+Traits+Among+UK+Biobank+Participants&rft.volume=141&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E956-%3C%2Fspan%3E964&rft.date=2023-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC10485742%23id-name%3DPMC&rft_id=info%3Apmid%2F37676684&rft_id=info%3Adoi%2F10.1001%2Fjamaophthalmol.2023.3877&rft.aulast=Kastner&rft.aufirst=A&rft.au=Stuart%2C+KV&rft.au=Montesano%2C+G&rft.au=De+Moraes%2C+CG&rft.au=Kang%2C+JH&rft.au=Wiggs%2C+JL&rft.au=Pasquale%2C+LR&rft.au=Hysi%2C+P&rft.au=Chua%2C+SY&rft.au=Patel%2C+PJ&rft.au=Foster%2C+PJ&rft.au=Khaw%2C+PT&rft.au=Khawaja%2C+AP&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC10485742&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-36">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAronson2014" class="citation book cs1">Aronson J (2014). <i>Side Effects of Drugs Annual 35</i>. Elsevier. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-444-62635-6" title="Special:BookSources/978-0-444-62635-6"><bdi>978-0-444-62635-6</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Side+Effects+of+Drugs+Annual+35&rft.pub=Elsevier&rft.date=2014&rft.isbn=978-0-444-62635-6&rft.aulast=Aronson&rft.aufirst=J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Pillay_2013-37"><span class="mw-cite-backlink">^ <a href="#cite_ref-Pillay_2013_37-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Pillay_2013_37-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFPillay2013" class="citation book cs1">Pillay V (2013). <i>Modern Medical Toxicology</i> (4th ed.). Jaypee. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-93-5025-965-8" title="Special:BookSources/978-93-5025-965-8"><bdi>978-93-5025-965-8</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Modern+Medical+Toxicology&rft.edition=4th&rft.pub=Jaypee&rft.date=2013&rft.isbn=978-93-5025-965-8&rft.aulast=Pillay&rft.aufirst=V&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-38">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHui2015" class="citation book cs1">Hui D (2015). <i>Approach to Internal Medicine: A Resource Book for Clinical Practice</i> (4th ed.). Springer. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-3-319-11820-8" title="Special:BookSources/978-3-319-11820-8"><bdi>978-3-319-11820-8</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Approach+to+Internal+Medicine%3A+A+Resource+Book+for+Clinical+Practice&rft.edition=4th&rft.pub=Springer&rft.date=2015&rft.isbn=978-3-319-11820-8&rft.aulast=Hui&rft.aufirst=D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-39"><span class="mw-cite-backlink"><b><a href="#cite_ref-39">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZuoZhouZhangYang2013" class="citation journal cs1">Zuo XC, Zhou YN, Zhang BK, Yang GP, Cheng ZN, Yuan H, et al. (2013). <a rel="nofollow" class="external text" href="https://www.jstage.jst.go.jp/article/dmpk/28/5/28_DMPK-12-RG-148/_pdf">"Effect of CYP3A5*3 polymorphism on pharmacokinetic drug interaction between tacrolimus and amlodipine"</a>. <i>Drug Metabolism and Pharmacokinetics</i>. <b>28</b> (5): <span class="nowrap">398–</span>405. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2133%2Fdmpk.DMPK-12-RG-148">10.2133/dmpk.DMPK-12-RG-148</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23438946">23438946</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170811010432/https://www.jstage.jst.go.jp/article/dmpk/28/5/28_DMPK-12-RG-148/_pdf">Archived</a> from the original on 11 August 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Pharmacokinetics&rft.atitle=Effect+of+CYP3A5%2A3+polymorphism+on+pharmacokinetic+drug+interaction+between+tacrolimus+and+amlodipine&rft.volume=28&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E398-%3C%2Fspan%3E405&rft.date=2013&rft_id=info%3Adoi%2F10.2133%2Fdmpk.DMPK-12-RG-148&rft_id=info%3Apmid%2F23438946&rft.aulast=Zuo&rft.aufirst=XC&rft.au=Zhou%2C+YN&rft.au=Zhang%2C+BK&rft.au=Yang%2C+GP&rft.au=Cheng%2C+ZN&rft.au=Yuan%2C+H&rft.au=Ouyang%2C+DS&rft.au=Liu%2C+SK&rft.au=Barrett%2C+JS&rft.au=Li%2C+PJ&rft.au=Liu%2C+Z&rft.au=Tan%2C+HY&rft.au=Guo%2C+R&rft.au=Zhou%2C+LY&rft.au=Xie%2C+YL&rft.au=Li%2C+ZJ&rft.au=Li%2C+J&rft.au=Wang%2C+CJ&rft.au=Wang%2C+JL&rft_id=https%3A%2F%2Fwww.jstage.jst.go.jp%2Farticle%2Fdmpk%2F28%2F5%2F28_DMPK-12-RG-148%2F_pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-40">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFCenter_for_Drug_Evaluation_and_Research2017" class="citation web cs1">Center for Drug Evaluation and Research (15 December 2017). <a rel="nofollow" class="external text" href="https://www.fda.gov/Drugs/DrugSafety/ucm256581.htm">"FDA Drug Safety Communication: New restrictions, contraindications, and dose limitations for Zocor (simvastatin) to reduce the risk of muscle injury"</a>. <i>Drug Safety and Availability</i>. FDA. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20130106223019/https://www.fda.gov/Drugs/DrugSafety/ucm256581.htm">Archived</a> from the original on 6 January 2013<span class="reference-accessdate">. Retrieved <span class="nowrap">30 April</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Drug+Safety+and+Availability&rft.atitle=FDA+Drug+Safety+Communication%3A+New+restrictions%2C+contraindications%2C+and+dose+limitations+for+Zocor+%28simvastatin%29+to+reduce+the+risk+of+muscle+injury&rft.date=2017-12-15&rft.au=Center+for+Drug+Evaluation+and+Research&rft_id=https%3A%2F%2Fwww.fda.gov%2FDrugs%2FDrugSafety%2Fucm256581.htm&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-41"><span class="mw-cite-backlink"><b><a href="#cite_ref-41">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFArmitageBowmanWallendszusBulbulia2010" class="citation journal cs1">Armitage J, Bowman L, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, et al. (November 2010). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988223">"Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: a double-blind randomised trial"</a>. <i>Lancet</i>. <b>376</b> (9753): <span class="nowrap">1658–</span>1669. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0140-6736%2810%2960310-8">10.1016/s0140-6736(10)60310-8</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2988223">2988223</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21067805">21067805</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Lancet&rft.atitle=Intensive+lowering+of+LDL+cholesterol+with+80+mg+versus+20+mg+simvastatin+daily+in+12%2C064+survivors+of+myocardial+infarction%3A+a+double-blind+randomised+trial&rft.volume=376&rft.issue=9753&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1658-%3C%2Fspan%3E1669&rft.date=2010-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2988223%23id-name%3DPMC&rft_id=info%3Apmid%2F21067805&rft_id=info%3Adoi%2F10.1016%2Fs0140-6736%2810%2960310-8&rft.aulast=Armitage&rft.aufirst=J&rft.au=Bowman%2C+L&rft.au=Wallendszus%2C+K&rft.au=Bulbulia%2C+R&rft.au=Rahimi%2C+K&rft.au=Haynes%2C+R&rft.au=Parish%2C+S&rft.au=Peto%2C+R&rft.au=Collins%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2988223&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-42">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAnanchenkoNovakovicLewis2012" class="citation book cs1">Ananchenko G, Novakovic J, Lewis J (1 January 2012). "Amlodipine Besylate". <i>Profiles of Drug Substances, Excipients, and Related Methodology</i>. Profiles of Drug Substances, Excipients and Related Methodology. Vol. 37. Academic Press. pp. <span class="nowrap">31–</span>77. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fb978-0-12-397220-0.00002-7">10.1016/b978-0-12-397220-0.00002-7</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780123972200" title="Special:BookSources/9780123972200"><bdi>9780123972200</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22469316">22469316</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:205142025">205142025</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Amlodipine+Besylate&rft.btitle=Profiles+of+Drug+Substances%2C+Excipients%2C+and+Related+Methodology&rft.series=Profiles+of+Drug+Substances%2C+Excipients+and+Related+Methodology&rft.pages=%3Cspan+class%3D%22nowrap%22%3E31-%3C%2Fspan%3E77&rft.pub=Academic+Press&rft.date=2012-01-01&rft_id=info%3Adoi%2F10.1016%2Fb978-0-12-397220-0.00002-7&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A205142025%23id-name%3DS2CID&rft_id=info%3Apmid%2F22469316&rft.isbn=9780123972200&rft.aulast=Ananchenko&rft.aufirst=G&rft.au=Novakovic%2C+J&rft.au=Lewis%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Amlodipine-43"><span class="mw-cite-backlink">^ <a href="#cite_ref-Amlodipine_43-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Amlodipine_43-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.drugbank.ca/drugs/DB00381">"Amlodipine"</a>. <i>www.drugbank.ca</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20190131040154/https://www.drugbank.ca/drugs/DB00381">Archived</a> from the original on 31 January 2019<span class="reference-accessdate">. Retrieved <span class="nowrap">30 January</span> 2019</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.drugbank.ca&rft.atitle=Amlodipine&rft_id=https%3A%2F%2Fwww.drugbank.ca%2Fdrugs%2FDB00381&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-44"><span class="mw-cite-backlink"><b><a href="#cite_ref-44">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFClusinAnderson1999" class="citation book cs1">Clusin WT, Anderson ME (1 January 1999). <i>Calcium Channel Blockers: Current Controversies and Basic Mechanisms of Action</i>. Advances in Pharmacology. Vol. 46. Academic Press. pp. <span class="nowrap">253–</span>296. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs1054-3589%2808%2960473-1">10.1016/s1054-3589(08)60473-1</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780120329472" title="Special:BookSources/9780120329472"><bdi>9780120329472</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10332505">10332505</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Calcium+Channel+Blockers%3A+Current+Controversies+and+Basic+Mechanisms+of+Action&rft.series=Advances+in+Pharmacology&rft.pages=%3Cspan+class%3D%22nowrap%22%3E253-%3C%2Fspan%3E296&rft.pub=Academic+Press&rft.date=1999-01-01&rft_id=info%3Apmid%2F10332505&rft_id=info%3Adoi%2F10.1016%2Fs1054-3589%2808%2960473-1&rft.isbn=9780120329472&rft.aulast=Clusin&rft.aufirst=WT&rft.au=Anderson%2C+ME&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Nazzaro_1995-45"><span class="mw-cite-backlink">^ <a href="#cite_ref-Nazzaro_1995_45-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Nazzaro_1995_45-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-Nazzaro_1995_45-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFNazzaroManzariMerloTriggiani1995" class="citation journal cs1">Nazzaro P, Manzari M, Merlo M, Triggiani R, Scarano AM, Lasciarrea A, et al. (September 1995). "Antihypertensive treatment with verapamil and amlodipine. Their effect on the functional autonomic and cardiovascular stress responses". <i>European Heart Journal</i>. <b>16</b> (9): <span class="nowrap">1277–</span>1284. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1093%2Foxfordjournals.eurheartj.a061086">10.1093/oxfordjournals.eurheartj.a061086</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/8582392">8582392</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=European+Heart+Journal&rft.atitle=Antihypertensive+treatment+with+verapamil+and+amlodipine.+Their+effect+on+the+functional+autonomic+and+cardiovascular+stress+responses&rft.volume=16&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1277-%3C%2Fspan%3E1284&rft.date=1995-09&rft_id=info%3Adoi%2F10.1093%2Foxfordjournals.eurheartj.a061086&rft_id=info%3Apmid%2F8582392&rft.aulast=Nazzaro&rft.aufirst=P&rft.au=Manzari%2C+M&rft.au=Merlo%2C+M&rft.au=Triggiani%2C+R&rft.au=Scarano%2C+AM&rft.au=Lasciarrea%2C+A&rft.au=Pirrelli%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-J.R._Karmokeretal.2016-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-J.R._Karmokeretal.2016_46-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKarmokerJoydharSarkarRahman2016" class="citation journal cs1">Karmoker JR, Joydhar P, Sarkar S, Rahman M (2016). <a rel="nofollow" class="external text" href="https://web.archive.org/web/20160701194238/http://www.ajphs.com/journals/02_AJPHS_Jan-Mar_2016_738.pdf">"Comparative in vitro evaluation of various commercial brands of amlodipine besylate tablets marketed in Bangladesh"</a> <span class="cs1-format">(PDF)</span>. <i>Asian Journal of Pharmaceutical and Health Sciences</i>. <b>6</b>: <span class="nowrap">1384–</span>1389. Archived from <a rel="nofollow" class="external text" href="http://www.ajphs.com/journals/02_AJPHS_Jan-Mar_2016_738.pdf">the original</a> <span class="cs1-format">(PDF)</span> on 1 July 2016<span class="reference-accessdate">. Retrieved <span class="nowrap">29 May</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Asian+Journal+of+Pharmaceutical+and+Health+Sciences&rft.atitle=Comparative+in+vitro+evaluation+of+various+commercial+brands+of+amlodipine+besylate+tablets+marketed+in+Bangladesh&rft.volume=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1384-%3C%2Fspan%3E1389&rft.date=2016&rft.aulast=Karmoker&rft.aufirst=JR&rft.au=Joydhar%2C+P&rft.au=Sarkar%2C+S&rft.au=Rahman%2C+M&rft_id=http%3A%2F%2Fwww.ajphs.com%2Fjournals%2F02_AJPHS_Jan-Mar_2016_738.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-47">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFArcangeloPeterson2006" class="citation book cs1">Arcangelo VP, Peterson AM (2006). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=EaP1yJz4fkEC&pg=PA252"><i>Pharmacotherapeutics for Advanced Practice: A Practical Approach</i></a>. Lippincott Williams & Wilkins. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780781757843" title="Special:BookSources/9780781757843"><bdi>9780781757843</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=EaP1yJz4fkEC&pg=PA252">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Pharmacotherapeutics+for+Advanced+Practice%3A+A+Practical+Approach&rft.pub=Lippincott+Williams+%26+Wilkins&rft.date=2006&rft.isbn=9780781757843&rft.aulast=Arcangelo&rft.aufirst=VP&rft.au=Peterson%2C+AM&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DEaP1yJz4fkEC%26pg%3DPA252&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-48"><span class="mw-cite-backlink"><b><a href="#cite_ref-48">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRitterLewisMantFerro2012" class="citation book cs1">Ritter J, Lewis L, Mant T, Ferro A (2012). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=TD59BgAAQBAJ&pg=PA191"><i>A Textbook of Clinical Pharmacology and Therapeutics</i></a> (5 ed.). CRC Press. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781444113006" title="Special:BookSources/9781444113006"><bdi>9781444113006</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=TD59BgAAQBAJ&pg=PA191">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=A+Textbook+of+Clinical+Pharmacology+and+Therapeutics&rft.edition=5&rft.pub=CRC+Press&rft.date=2012&rft.isbn=9781444113006&rft.aulast=Ritter&rft.aufirst=J&rft.au=Lewis%2C+L&rft.au=Mant%2C+T&rft.au=Ferro%2C+A&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DTD59BgAAQBAJ%26pg%3DPA191&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-49"><span class="mw-cite-backlink"><b><a href="#cite_ref-49">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLi2015" class="citation book cs1">Li YR (2015). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=rXy0BgAAQBAJ&pg=PA189"><i>Cardiovascular Diseases: From Molecular Pharmacology to Evidence-Based Therapeutics</i></a>. John Wiley & Sons. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780470915370" title="Special:BookSources/9780470915370"><bdi>9780470915370</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=rXy0BgAAQBAJ&pg=PA189">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Cardiovascular+Diseases%3A+From+Molecular+Pharmacology+to+Evidence-Based+Therapeutics&rft.pub=John+Wiley+%26+Sons&rft.date=2015&rft.isbn=9780470915370&rft.aulast=Li&rft.aufirst=YR&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DrXy0BgAAQBAJ%26pg%3DPA189&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-50">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation book cs1"><a rel="nofollow" class="external text" href="https://books.google.com/books?id=ckdTGZe7aRAC&pg=PA73"><i>2013 Nurse's Drug Handbook</i></a>. Jones & Bartlett Publishers. 2012. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781449642846" title="Special:BookSources/9781449642846"><bdi>9781449642846</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192421/https://books.google.com/books?id=ckdTGZe7aRAC&pg=PA73">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=2013+Nurse%27s+Drug+Handbook&rft.pub=Jones+%26+Bartlett+Publishers&rft.date=2012&rft.isbn=9781449642846&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DckdTGZe7aRAC%26pg%3DPA73&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-Luther2014-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-Luther2014_51-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLuther2014" class="citation journal cs1">Luther JM (September 2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248353">"Is there a new dawn for selective mineralocorticoid receptor antagonism?"</a>. <i>Current Opinion in Nephrology and Hypertension</i>. <b>23</b> (5): <span class="nowrap">456–</span>461. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FMNH.0000000000000051">10.1097/MNH.0000000000000051</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4248353">4248353</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24992570">24992570</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Opinion+in+Nephrology+and+Hypertension&rft.atitle=Is+there+a+new+dawn+for+selective+mineralocorticoid+receptor+antagonism%3F&rft.volume=23&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E456-%3C%2Fspan%3E461&rft.date=2014-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4248353%23id-name%3DPMC&rft_id=info%3Apmid%2F24992570&rft_id=info%3Adoi%2F10.1097%2FMNH.0000000000000051&rft.aulast=Luther&rft.aufirst=JM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4248353&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-52">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZhuWangLiZhu2014" class="citation journal cs1">Zhu Y, Wang F, Li Q, Zhu M, Du A, Tang W, et al. (February 2014). "Amlodipine metabolism in human liver microsomes and roles of CYP3A4/5 in the dihydropyridine dehydrogenation". <i>Drug Metabolism and Disposition</i>. <b>42</b> (2): <span class="nowrap">245–</span>249. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1124%2Fdmd.113.055400">10.1124/dmd.113.055400</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24301608">24301608</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:329321">329321</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drug+Metabolism+and+Disposition&rft.atitle=Amlodipine+metabolism+in+human+liver+microsomes+and+roles+of+CYP3A4%2F5+in+the+dihydropyridine+dehydrogenation&rft.volume=42&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E245-%3C%2Fspan%3E249&rft.date=2014-02&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A329321%23id-name%3DS2CID&rft_id=info%3Apmid%2F24301608&rft_id=info%3Adoi%2F10.1124%2Fdmd.113.055400&rft.aulast=Zhu&rft.aufirst=Y&rft.au=Wang%2C+F&rft.au=Li%2C+Q&rft.au=Zhu%2C+M&rft.au=Du%2C+A&rft.au=Tang%2C+W&rft.au=Chen%2C+W&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-pmid2967593-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid2967593_53-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBeresfordMcGibneyHumphreyMacrae1988" class="citation journal cs1">Beresford AP, McGibney D, Humphrey MJ, Macrae PV, Stopher DA (February 1988). "Metabolism and kinetics of amlodipine in man". <i>Xenobiotica; the Fate of Foreign Compounds in Biological Systems</i>. <b>18</b> (2): <span class="nowrap">245–</span>254. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3109%2F00498258809041660">10.3109/00498258809041660</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2967593">2967593</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Xenobiotica%3B+the+Fate+of+Foreign+Compounds+in+Biological+Systems&rft.atitle=Metabolism+and+kinetics+of+amlodipine+in+man&rft.volume=18&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E245-%3C%2Fspan%3E254&rft.date=1988-02&rft_id=info%3Adoi%2F10.3109%2F00498258809041660&rft_id=info%3Apmid%2F2967593&rft.aulast=Beresford&rft.aufirst=AP&rft.au=McGibney%2C+D&rft.au=Humphrey%2C+MJ&rft.au=Macrae%2C+PV&rft.au=Stopher%2C+DA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span><span style="position:relative; top: -2px;"><span typeof="mw:File"><a href="/wiki/Paywall" title="closed access publication – behind paywall"><img alt="Closed access icon" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/9px-Closed_Access_logo_transparent.svg.png" decoding="async" width="9" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/14px-Closed_Access_logo_transparent.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/0e/Closed_Access_logo_transparent.svg/18px-Closed_Access_logo_transparent.svg.png 2x" data-file-width="640" data-file-height="1000" /></a></span></span></span> </li> <li id="cite_note-54"><span class="mw-cite-backlink"><b><a href="#cite_ref-54">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFNayler2012" class="citation book cs1">Nayler WG (2012). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=Z5T0BwAAQBAJ&pg=PT105"><i>Amlodipine</i></a>. Springer Science & Business Media. p. 105. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9783642782237" title="Special:BookSources/9783642782237"><bdi>9783642782237</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=Z5T0BwAAQBAJ&pg=PT105">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Amlodipine&rft.pages=105&rft.pub=Springer+Science+%26+Business+Media&rft.date=2012&rft.isbn=9783642782237&rft.aulast=Nayler&rft.aufirst=WG&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DZ5T0BwAAQBAJ%26pg%3DPT105&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-55"><span class="mw-cite-backlink"><b><a href="#cite_ref-55">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBrittain2012" class="citation book cs1">Brittain HG (2012). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=ew_MiZ_xBdcC&pg=PA68"><i>Profiles of Drug Substances, Excipients and Related Methodology</i></a>. Academic Press. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9780123977564" title="Special:BookSources/9780123977564"><bdi>9780123977564</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170908192420/https://books.google.com/books?id=ew_MiZ_xBdcC&pg=PA68">Archived</a> from the original on 8 September 2017.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Profiles+of+Drug+Substances%2C+Excipients+and+Related+Methodology&rft.pub=Academic+Press&rft.date=2012&rft.isbn=9780123977564&rft.aulast=Brittain&rft.aufirst=HG&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3Dew_MiZ_xBdcC%26pg%3DPA68&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-56"><span class="mw-cite-backlink"><b><a href="#cite_ref-56">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMurdochHeel1991" class="citation journal cs1">Murdoch D, Heel RC (March 1991). "Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease". <i>Drugs</i>. <b>41</b> (3): <span class="nowrap">478–</span>505. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.2165%2F00003495-199141030-00009">10.2165/00003495-199141030-00009</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1711448">1711448</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:195693179">195693179</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Drugs&rft.atitle=Amlodipine.+A+review+of+its+pharmacodynamic+and+pharmacokinetic+properties%2C+and+therapeutic+use+in+cardiovascular+disease&rft.volume=41&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E478-%3C%2Fspan%3E505&rft.date=1991-03&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A195693179%23id-name%3DS2CID&rft_id=info%3Apmid%2F1711448&rft_id=info%3Adoi%2F10.2165%2F00003495-199141030-00009&rft.aulast=Murdoch&rft.aufirst=D&rft.au=Heel%2C+RC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-57"><span class="mw-cite-backlink"><b><a href="#cite_ref-57">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKennedy2007" class="citation news cs1">Kennedy VB (22 March 2007). <a rel="nofollow" class="external text" href="http://www.marketwatch.com/news/story/pfizer-loses-court-ruling-norvasc/story.aspx?guid=%7B9819D67E-B76B-431D-835C-FB8D6D8327B7%7D">"Pfizer loses court ruling on Norvasc patent"</a>. <i>MarketWatch</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20080803060500/http://www.marketwatch.com/news/story/pfizer-loses-court-ruling-norvasc/story.aspx?guid=%7B9819D67E-B76B-431D-835C-FB8D6D8327B7%7D">Archived</a> from the original on 3 August 2008.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=MarketWatch&rft.atitle=Pfizer+loses+court+ruling+on+Norvasc+patent&rft.date=2007-03-22&rft.aulast=Kennedy&rft.aufirst=VB&rft_id=http%3A%2F%2Fwww.marketwatch.com%2Fnews%2Fstory%2Fpfizer-loses-court-ruling-norvasc%2Fstory.aspx%3Fguid%3D%257B9819D67E-B76B-431D-835C-FB8D6D8327B7%257D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-58"><span class="mw-cite-backlink"><b><a href="#cite_ref-58">^</a></b></span> <span class="reference-text"><span title="www.drugs.com"><a rel="nofollow" class="external text" href="https://www.drugs.com/mtm/amlodipine-and-perindopril.html">Multum Consumer Information</a></span> on amlodipine and perindopril. Accessed 28 February 2020.</span> </li> <li id="cite_note-59"><span class="mw-cite-backlink"><b><a href="#cite_ref-59">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFCampbell2014" class="citation book cs1">Campbell AK (14 October 2014). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=aDbcBAAAQBAJ&pg=PA68"><i>Intracellular Calcium</i></a>. John Wiley & Sons. p. 68. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781118675526" title="Special:BookSources/9781118675526"><bdi>9781118675526</bdi></a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20210101093831/https://books.google.com/books?id=aDbcBAAAQBAJ&pg=PA68">Archived</a> from the original on 1 January 2021<span class="reference-accessdate">. Retrieved <span class="nowrap">10 August</span> 2016</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Intracellular+Calcium&rft.pages=68&rft.pub=John+Wiley+%26+Sons&rft.date=2014-10-14&rft.isbn=9781118675526&rft.aulast=Campbell&rft.aufirst=AK&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DaDbcBAAAQBAJ%26pg%3DPA68&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-60"><span class="mw-cite-backlink"><b><a href="#cite_ref-60">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.businesswire.com/news/home/20201116005378/en/">"Pfizer Completes Transaction to Combine Its Upjohn Business with Mylan"</a>. Pfizer. 16 November 2020<span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2024</span> – via Business Wire.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=unknown&rft.btitle=Pfizer+Completes+Transaction+to+Combine+Its+Upjohn+Business+with+Mylan&rft.pub=Pfizer&rft.date=2020-11-16&rft_id=https%3A%2F%2Fwww.businesswire.com%2Fnews%2Fhome%2F20201116005378%2Fen%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-61"><span class="mw-cite-backlink"><b><a href="#cite_ref-61">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.pfizer.com/products/product-detail/norvasc">"Norvasc"</a>. <i>Pfizer</i><span class="reference-accessdate">. Retrieved <span class="nowrap">17 June</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Pfizer&rft.atitle=Norvasc&rft_id=https%3A%2F%2Fwww.pfizer.com%2Fproducts%2Fproduct-detail%2Fnorvasc&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-papich-62"><span class="mw-cite-backlink"><b><a href="#cite_ref-papich_62-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFPapich2007" class="citation book cs1">Papich MG (2007). "Amlodipine Besylate". <i>Saunders Handbook of Veterinary Drugs</i> (2nd ed.). St. Louis, Mo: Saunders/Elsevier. pp. <span class="nowrap">26–</span>27. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/9781416028888" title="Special:BookSources/9781416028888"><bdi>9781416028888</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Amlodipine+Besylate&rft.btitle=Saunders+Handbook+of+Veterinary+Drugs&rft.place=St.+Louis%2C+Mo&rft.pages=%3Cspan+class%3D%22nowrap%22%3E26-%3C%2Fspan%3E27&rft.edition=2nd&rft.pub=Saunders%2FElsevier&rft.date=2007&rft.isbn=9781416028888&rft.aulast=Papich&rft.aufirst=MG&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-63"><span class="mw-cite-backlink"><b><a href="#cite_ref-63">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHenikSnyderVolk2014" class="citation journal cs1">Henik RA, Snyder PS, Volk LM (28 August 2014). "Treatment of systemic hypertension in cats with amlodipine besylate". <i>Journal of the American Animal Hospital Association</i>. <b>33</b> (3): <span class="nowrap">226–</span>234. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.5326%2F15473317-33-3-226">10.5326/15473317-33-3-226</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9138233">9138233</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+the+American+Animal+Hospital+Association&rft.atitle=Treatment+of+systemic+hypertension+in+cats+with+amlodipine+besylate&rft.volume=33&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E226-%3C%2Fspan%3E234&rft.date=2014-08-28&rft_id=info%3Adoi%2F10.5326%2F15473317-33-3-226&rft_id=info%3Apmid%2F9138233&rft.aulast=Henik&rft.aufirst=RA&rft.au=Snyder%2C+PS&rft.au=Volk%2C+LM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-diamondback-64"><span class="mw-cite-backlink"><b><a href="#cite_ref-diamondback_64-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="http://www.diamondbackdrugs.com/treating-high-blood-pressure-with-amlodipine/">"Amlodipine in Veterinary Medicine"</a>. <i>Diamondback Drugs</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170811011323/http://www.diamondbackdrugs.com/treating-high-blood-pressure-with-amlodipine/">Archived</a> from the original on 11 August 2017<span class="reference-accessdate">. Retrieved <span class="nowrap">29 June</span> 2017</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Diamondback+Drugs&rft.atitle=Amlodipine+in+Veterinary+Medicine&rft_id=http%3A%2F%2Fwww.diamondbackdrugs.com%2Ftreating-high-blood-pressure-with-amlodipine%2F&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-65"><span class="mw-cite-backlink"><b><a href="#cite_ref-65">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAtkinsBonaguraEttingerFox2009" class="citation journal cs1">Atkins C, Bonagura J, Ettinger S, Fox P, Gordon S, Haggstrom J, et al. (1 November 2009). <a rel="nofollow" class="external text" href="https://rvc-repository.worktribe.com/preview/1650595/10.1016%20j%20jevs%202023%20104896.pdf">"Guidelines for the diagnosis and treatment of canine chronic valvular heart disease"</a> <span class="cs1-format">(PDF)</span>. <i>Journal of Veterinary Internal Medicine</i>. <b>23</b> (6): <span class="nowrap">1142–</span>1150. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1939-1676.2009.0392.x">10.1111/j.1939-1676.2009.0392.x</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19780929">19780929</a>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20240110170518/https://rvc-repository.worktribe.com/preview/1650595/10.1016%20j%20jevs%202023%20104896.pdf">Archived</a> <span class="cs1-format">(PDF)</span> from the original on 10 January 2024<span class="reference-accessdate">. Retrieved <span class="nowrap">13 January</span> 2024</span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Veterinary+Internal+Medicine&rft.atitle=Guidelines+for+the+diagnosis+and+treatment+of+canine+chronic+valvular+heart+disease&rft.volume=23&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1142-%3C%2Fspan%3E1150&rft.date=2009-11-01&rft_id=info%3Adoi%2F10.1111%2Fj.1939-1676.2009.0392.x&rft_id=info%3Apmid%2F19780929&rft.aulast=Atkins&rft.aufirst=C&rft.au=Bonagura%2C+J&rft.au=Ettinger%2C+S&rft.au=Fox%2C+P&rft.au=Gordon%2C+S&rft.au=Haggstrom%2C+J&rft.au=Hamlin%2C+R&rft.au=Keene%2C+B&rft.au=Luis-Fuentes%2C+V&rft.au=Stepien%2C+R&rft_id=https%3A%2F%2Frvc-repository.worktribe.com%2Fpreview%2F1650595%2F10.1016%2520j%2520jevs%25202023%2520104896.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-66"><span class="mw-cite-backlink"><b><a href="#cite_ref-66">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSuzukiFukushimaIshikawaYamamoto2012" class="citation journal cs1">Suzuki S, Fukushima R, Ishikawa T, Yamamoto Y, Hamabe L, Kim S, et al. (September 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489586">"Comparative effects of amlodipine and benazepril on left atrial pressure in dogs with experimentally-induced mitral valve regurgitation"</a>. <i>BMC Veterinary Research</i>. <b>8</b>: 166. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1746-6148-8-166">10.1186/1746-6148-8-166</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489586">3489586</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22989022">22989022</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMC+Veterinary+Research&rft.atitle=Comparative+effects+of+amlodipine+and+benazepril+on+left+atrial+pressure+in+dogs+with+experimentally-induced+mitral+valve+regurgitation&rft.volume=8&rft.pages=166&rft.date=2012-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3489586%23id-name%3DPMC&rft_id=info%3Apmid%2F22989022&rft_id=info%3Adoi%2F10.1186%2F1746-6148-8-166&rft.aulast=Suzuki&rft.aufirst=S&rft.au=Fukushima%2C+R&rft.au=Ishikawa%2C+T&rft.au=Yamamoto%2C+Y&rft.au=Hamabe%2C+L&rft.au=Kim%2C+S&rft.au=Yoshiyuki%2C+R&rft.au=Machida%2C+N&rft.au=Tanaka%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3489586&rfr_id=info%3Asid%2Fen.wikipedia.org%3AAmlodipine" class="Z3988"></span></span> </li> <li id="cite_note-wedgewood-67"><span class="mw-cite-backlink"><b><a href="#cite_ref-wedgewood_67-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFForney" class="citation web cs1">Forney B. <a rel="nofollow" class="external text" href="http://www.wedgewoodpetrx.com/learning-center/professional-monographs/amlodipine-for-veterinary-use.html">"Amlodipine for Veterinary Use"</a>. <i>Wedgewood Pharmacy</i>. <a rel="nofollow" class="external text" href="https://web.archive.org/web/20170627172329/http://www.wedgewoodpetrx.com/learning-center/professional-monographs/amlodipine-for-veterinary-use.html">Archived</a> from the original on 27 June 2017<span class="reference-accessdate">. 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ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:" ("counter(listitem)"\a0 "}</style><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Ion_channel_modulators357" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><style data-mw-deduplicate="TemplateStyles:r1239400231">.mw-parser-output .navbar{display:inline;font-size:88%;font-weight:normal}.mw-parser-output .navbar-collapse{float:left;text-align:left}.mw-parser-output .navbar-boxtext{word-spacing:0}.mw-parser-output .navbar ul{display:inline-block;white-space:nowrap;line-height:inherit}.mw-parser-output .navbar-brackets::before{margin-right:-0.125em;content:"[ 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href="/wiki/Template_talk:Ion_channel_modulators" title="Template talk:Ion channel modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Ion_channel_modulators" title="Special:EditPage/Template:Ion channel modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Ion_channel_modulators357" style="font-size:114%;margin:0 4em"><a href="/wiki/Channel_modulator" title="Channel modulator">Ion channel modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Calcium_channel" title="Calcium channel">Calcium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="VDCCsTooltip_Voltage-dependent_calcium_channels424" scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-dependent_calcium_channels" class="mw-redirect" title="Voltage-dependent calcium channels"><abbr title="Voltage-dependent calcium channels">VDCCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-dependent calcium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_blocker" title="Calcium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <i><a href="/wiki/Dihydropyridine" class="mw-redirect" title="Dihydropyridine">Dihydropyridines</a>:</i> <a class="mw-selflink selflink">Amlodipine</a></li> <li><a href="/wiki/Aranidipine" title="Aranidipine">Aranidipine</a></li> <li><a href="/wiki/Azelnidipine" title="Azelnidipine">Azelnidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Barnidipine</a></li> <li><a href="/wiki/Clevidipine" title="Clevidipine">Clevidipine</a></li> <li><a href="/w/index.php?title=Cronidipine&action=edit&redlink=1" class="new" title="Cronidipine (page does not exist)">Cronidipine</a></li> <li><a href="/wiki/Darodipine" title="Darodipine">Darodipine</a></li> <li><a href="/w/index.php?title=Dexniguldipine&action=edit&redlink=1" class="new" title="Dexniguldipine (page does not exist)">Dexniguldipine</a></li> <li><a href="/w/index.php?title=Elgodipine&action=edit&redlink=1" class="new" title="Elgodipine (page does not exist)">Elgodipine</a></li> <li><a href="/w/index.php?title=Elnadipine&action=edit&redlink=1" class="new" title="Elnadipine (page does not exist)">Elnadipine</a></li> <li><a href="/wiki/Felodipine" title="Felodipine">Felodipine</a></li> <li><a href="/w/index.php?title=Flordipine&action=edit&redlink=1" class="new" title="Flordipine (page does not exist)">Flordipine</a></li> <li><a href="/w/index.php?title=Furnidipine&action=edit&redlink=1" class="new" title="Furnidipine (page does not exist)">Furnidipine</a></li> <li><a href="/w/index.php?title=Iganidipine&action=edit&redlink=1" class="new" title="Iganidipine (page does not exist)">Iganidipine</a></li> <li><a href="/wiki/Isradipine" title="Isradipine">Isradipine</a></li> <li><a href="/wiki/Lacidipine" title="Lacidipine">Lacidipine</a></li> <li><a href="/w/index.php?title=Lemildipine&action=edit&redlink=1" class="new" title="Lemildipine (page does not exist)">Lemildipine</a></li> <li><a href="/wiki/Lercanidipine" title="Lercanidipine">Lercanidipine</a></li> <li><a href="/wiki/Levamlodipine" title="Levamlodipine">Levamlodipine</a></li> <li><a href="/w/index.php?title=Levniguldipine&action=edit&redlink=1" class="new" title="Levniguldipine (page does not exist)">Levniguldipine</a></li> <li><a href="/wiki/Manidipine" title="Manidipine">Manidipine</a></li> <li><a href="/wiki/Barnidipine" title="Barnidipine">Mepirodipine</a></li> <li><a href="/w/index.php?title=Mesudipine&action=edit&redlink=1" class="new" title="Mesudipine (page does not exist)">Mesudipine</a></li> <li><a href="/wiki/Nicardipine" title="Nicardipine">Nicardipine</a></li> <li><a href="/wiki/Nifedipine" title="Nifedipine">Nifedipine</a></li> <li><a href="/wiki/Niguldipine" title="Niguldipine">Niguldipine</a></li> <li><a href="/wiki/Niludipine" title="Niludipine">Niludipine</a></li> <li><a href="/wiki/Nilvadipine" title="Nilvadipine">Nilvadipine</a></li> <li><a href="/wiki/Nimodipine" title="Nimodipine">Nimodipine</a></li> <li><a href="/wiki/Nisoldipine" title="Nisoldipine">Nisoldipine</a></li> <li><a href="/wiki/Nitrendipine" title="Nitrendipine">Nitrendipine</a></li> <li><a href="/w/index.php?title=Olradipine&action=edit&redlink=1" class="new" title="Olradipine (page does not exist)">Olradipine</a></li> <li><a href="/wiki/Oxodipine" title="Oxodipine">Oxodipine</a></li> <li><a href="/w/index.php?title=Palonidipine&action=edit&redlink=1" class="new" title="Palonidipine (page does not exist)">Palonidipine</a></li> <li><a href="/wiki/Pranidipine" title="Pranidipine">Pranidipine</a></li> <li><a href="/wiki/Riodipine" title="Riodipine">Ryodipine (riodipine)</a></li> <li><a href="/w/index.php?title=Sagandipine&action=edit&redlink=1" class="new" title="Sagandipine (page does not exist)">Sagandipine</a></li> <li><a href="/w/index.php?title=Sornidipine&action=edit&redlink=1" class="new" title="Sornidipine (page does not exist)">Sornidipine</a></li> <li><a href="/w/index.php?title=Teludipine&action=edit&redlink=1" class="new" title="Teludipine (page does not exist)">Teludipine</a></li> <li><a href="/w/index.php?title=Tiamdipine&action=edit&redlink=1" class="new" title="Tiamdipine (page does not exist)">Tiamdipine</a></li> <li><a href="/w/index.php?title=Trombodipine&action=edit&redlink=1" class="new" title="Trombodipine (page does not exist)">Trombodipine</a></li> <li><a href="/w/index.php?title=Vatanidipine&action=edit&redlink=1" class="new" title="Vatanidipine (page does not exist)">Vatanidipine</a>; <i><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a> derivatives:</i> <a href="/wiki/Clentiazem" title="Clentiazem">Clentiazem</a></li> <li><a href="/wiki/Diltiazem" title="Diltiazem">Diltiazem</a></li> <li><a href="/w/index.php?title=Iprotiazem&action=edit&redlink=1" class="new" title="Iprotiazem (page does not exist)">Iprotiazem</a></li> <li><a href="/w/index.php?title=Nictiazem&action=edit&redlink=1" class="new" title="Nictiazem (page does not exist)">Nictiazem</a></li> <li><a href="/w/index.php?title=Siratiazem&action=edit&redlink=1" class="new" title="Siratiazem (page does not exist)">Siratiazem</a>; <i><a href="/wiki/Arylalkylamine" title="Arylalkylamine">Phenylalkylamines</a>:</i> <a href="/wiki/Anipamil" title="Anipamil">Anipamil</a></li> <li><a href="/w/index.php?title=Dagapamil&action=edit&redlink=1" class="new" title="Dagapamil (page does not exist)">Dagapamil</a></li> <li><a href="/wiki/Devapamil" title="Devapamil">Devapamil</a></li> <li><a href="/w/index.php?title=Dexverapamil&action=edit&redlink=1" class="new" title="Dexverapamil (page does not exist)">Dexverapamil</a></li> <li><a href="/wiki/Emopamil" title="Emopamil">Emopamil</a></li> <li><a href="/w/index.php?title=Etripamil&action=edit&redlink=1" class="new" title="Etripamil (page does not exist)">Etripamil</a></li> <li><a href="/wiki/Falipamil" title="Falipamil">Falipamil</a></li> <li><a href="/wiki/Gallopamil" title="Gallopamil">Gallopamil</a></li> <li><a href="/w/index.php?title=Levemopamil&action=edit&redlink=1" class="new" title="Levemopamil (page does not exist)">Levemopamil</a></li> <li><a href="/w/index.php?title=Nexopamil&action=edit&redlink=1" class="new" title="Nexopamil (page does not exist)">Nexopamil</a></li> <li><a href="/wiki/Norverapamil" title="Norverapamil">Norverapamil</a></li> <li><a href="/w/index.php?title=Ronipamil&action=edit&redlink=1" class="new" title="Ronipamil (page does not exist)">Ronipamil</a></li> <li><a href="/wiki/Tiapamil" title="Tiapamil">Tiapamil</a></li> <li><a href="/wiki/Verapamil" title="Verapamil">Verapamil</a>; <i>Others:</i> <a href="/wiki/AH-1058" title="AH-1058">AH-1058</a></li> <li><a href="/w/index.php?title=Brinazarone&action=edit&redlink=1" class="new" title="Brinazarone (page does not exist)">Brinazarone</a></li> <li><a href="/wiki/Budiodarone" title="Budiodarone">Budiodarone</a></li> <li><a href="/wiki/Celivarone" title="Celivarone">Celivarone</a></li> <li><a href="/wiki/Cyproheptadine" title="Cyproheptadine">Cyproheptadine</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Fantofarone" title="Fantofarone">Fantofarone</a></li> <li><a href="/w/index.php?title=SR-33805&action=edit&redlink=1" class="new" title="SR-33805 (page does not exist)">SR-33805</a></li> <li><a href="/wiki/Tetrahydropalmatine" title="Tetrahydropalmatine">Tetrahydropalmatine</a></li></ul> <ul><li><b><a href="/wiki/N-type_calcium_channel" title="N-type calcium channel">N-type-selective</a>:</b> <a href="/wiki/%CE%A9-Conotoxin" class="mw-redirect" title="Ω-Conotoxin">ω-Conotoxins</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_GVIA&action=edit&redlink=1" class="new" title="Ω-Conotoxin GVIA (page does not exist)">ω-Conotoxin GVIA</a></li> <li><a href="/wiki/Caroverine" title="Caroverine">Caroverine</a></li> <li><a href="/w/index.php?title=Huwentoxin_XVI&action=edit&redlink=1" class="new" title="Huwentoxin XVI (page does not exist)">Huwentoxin XVI</a></li> <li><a href="/wiki/Leconotide" title="Leconotide">Leconotide (ω-conotoxin CVID)</a></li> <li><a href="/w/index.php?title=PD-173212&action=edit&redlink=1" class="new" title="PD-173212 (page does not exist)">PD-173212</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/w/index.php?title=Z160&action=edit&redlink=1" class="new" title="Z160 (page does not exist)">Z160</a></li> <li><a href="/wiki/Ziconotide" title="Ziconotide">Ziconotide (ω-conotoxin MVIIA)</a></li></ul> <ul><li><b><a href="/wiki/P-type_calcium_channel" title="P-type calcium channel">P-type-selective</a>:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_IVA&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVA (page does not exist)">ω-Agatoxin IVA</a></li> <li><a href="/w/index.php?title=%CE%A9-Agatoxin_IVB&action=edit&redlink=1" class="new" title="Ω-Agatoxin IVB (page does not exist)">ω-Agatoxin IVB</a></li></ul> <ul><li><b><a href="/wiki/R-type_calcium_channel" title="R-type calcium channel">R-type-selective</a>:</b> <a href="/wiki/SNX-482" title="SNX-482">SNX-482</a></li></ul> <ul><li><b><a href="/wiki/T-type_calcium_channel" title="T-type calcium channel">T-type-selective</a>:</b> <a href="/w/index.php?title=ABT-639&action=edit&redlink=1" class="new" title="ABT-639 (page does not exist)">ABT-639</a></li> <li><a href="/w/index.php?title=ML-218&action=edit&redlink=1" class="new" title="ML-218 (page does not exist)">ML-218</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=NNC_55-0396&action=edit&redlink=1" class="new" title="NNC 55-0396 (page does not exist)">NNC 55-0396</a></li> <li><a href="/w/index.php?title=ProTx_I&action=edit&redlink=1" class="new" title="ProTx I (page does not exist)">ProTx I</a></li> <li><a href="/w/index.php?title=Z944&action=edit&redlink=1" class="new" title="Z944 (page does not exist)">Z944</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><b>Non-selective:</b> <a href="/w/index.php?title=%CE%A9-Agatoxin_TK&action=edit&redlink=1" class="new" title="Ω-Agatoxin TK (page does not exist)">ω-Agatoxin TK</a></li> <li><a href="/w/index.php?title=%CE%A9-Conotoxin_MVIIC&action=edit&redlink=1" class="new" title="Ω-Conotoxin MVIIC (page does not exist)">ω-Conotoxin MVIIC</a></li> <li><a href="/wiki/Benidipine" title="Benidipine">Benidipine</a></li> <li><a href="/wiki/Bepridil" title="Bepridil">Bepridil</a></li> <li><a href="/wiki/Cilnidipine" title="Cilnidipine">Cilnidipine</a></li> <li><a href="/wiki/Cinnarizine" title="Cinnarizine">Cinnarizine</a></li> <li><a href="/wiki/Dotarizine" title="Dotarizine">Dotarizine</a></li> <li><a href="/wiki/Efonidipine" title="Efonidipine">Efonidipine</a></li> <li><a href="/wiki/Flunarizine" title="Flunarizine">Flunarizine</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Levetiracetam" title="Levetiracetam">Levetiracetam</a></li> <li><a href="/wiki/Lomerizine" title="Lomerizine">Lomerizine</a></li> <li><a href="/wiki/Loperamide" title="Loperamide">Loperamide</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/w/index.php?title=NP078585&action=edit&redlink=1" class="new" title="NP078585 (page does not exist)">NP078585</a></li> <li><a href="/wiki/Ruthenium_red" title="Ruthenium red">Ruthenium red</a></li> <li><a href="/wiki/TROX-1" title="TROX-1">TROX-1</a></li></ul> <ul><li><b><a href="/wiki/Voltage-dependent_calcium_channel#α2δ_Subunit" class="mw-redirect" title="Voltage-dependent calcium channel">α<sub>2</sub>δ subunit</a>-selective (<a href="/wiki/Gabapentinoid" title="Gabapentinoid">gabapentinoids</a>):</b> <a href="/wiki/4-Methylpregabalin" title="4-Methylpregabalin">4-Methylpregabalin</a></li> <li><a href="/wiki/Arbaclofen" class="mw-redirect" title="Arbaclofen">Arbaclofen</a></li> <li><a href="/wiki/Arbaclofen_placarbil" title="Arbaclofen placarbil">Arbaclofen placarbil</a></li> <li><a href="/wiki/Atagabalin" title="Atagabalin">Atagabalin</a></li> <li><a href="/wiki/Baclofen" title="Baclofen">Baclofen</a></li> <li><a href="/wiki/Gabapentin" title="Gabapentin">Gabapentin</a></li> <li><a href="/wiki/Gabapentin_enacarbil" title="Gabapentin enacarbil">Gabapentin enacarbil</a></li> <li><a href="/wiki/Imagabalin" title="Imagabalin">Imagabalin</a></li> <li><a href="/wiki/Mirogabalin" title="Mirogabalin">Mirogabalin</a></li> <li><a href="/w/index.php?title=PD-200,347&action=edit&redlink=1" class="new" title="PD-200,347 (page does not exist)">PD-200,347</a></li> <li><a href="/wiki/PD-217,014" title="PD-217,014">PD-217,014</a></li> <li><a href="/w/index.php?title=PD-299,685&action=edit&redlink=1" class="new" title="PD-299,685 (page does not exist)">PD-299,685</a></li> <li><a href="/wiki/Phenibut" title="Phenibut">Phenibut</a></li> <li><a href="/wiki/Pregabalin" title="Pregabalin">Pregabalin</a></li></ul> <ul><li><b>Others/unsorted:</b> <a href="/wiki/Bencyclane" title="Bencyclane">Bencyclane</a></li> <li><a href="/wiki/Berbamine" title="Berbamine">Berbamine</a></li> <li><a href="/wiki/Bevantolol" title="Bevantolol">Bevantolol</a></li> <li><a href="/wiki/Canadine" title="Canadine">Canadine</a></li> <li><a href="/wiki/Carboxyamidotriazole" title="Carboxyamidotriazole">Carboxyamidotriazole</a></li> <li><a href="/wiki/Cycleanine" title="Cycleanine">Cycleanine</a></li> <li><a href="/wiki/Dauricine" title="Dauricine">Dauricine</a></li> <li><a href="/wiki/Dimeditiapramine" class="mw-redirect" title="Dimeditiapramine">Dimeditiapramine</a></li> <li><a href="/wiki/Diproteverine" title="Diproteverine">Diproteverine</a></li> <li><a href="/wiki/Enpiperate" title="Enpiperate">Enpiperate</a></li> <li><a href="/wiki/Eperisone" title="Eperisone">Eperisone</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Ethadione" title="Ethadione">Ethadione</a></li> <li><a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Fasudil" title="Fasudil">Fasudil</a></li> <li><a href="/wiki/Fendiline" title="Fendiline">Fendiline</a></li> <li><a href="/wiki/Fostedil" title="Fostedil">Fostedil</a></li> <li><a href="/wiki/Imepitoin" title="Imepitoin">Imepitoin</a></li> <li><a href="/wiki/JTV-519" title="JTV-519">JTV-519</a></li> <li><a href="/wiki/Lidoflazine" title="Lidoflazine">Lidoflazine</a></li> <li><a href="/wiki/Magnesium" title="Magnesium">Magnesium</a></li> <li><a href="/wiki/Manoalide" title="Manoalide">Manoalide</a></li> <li><a href="/wiki/Mesuximide" title="Mesuximide">Mesuximide</a></li> <li><a href="/wiki/Monatepil" title="Monatepil">Monatepil</a></li> <li><a href="/wiki/Naftopidil" title="Naftopidil">Naftopidil</a></li> <li><a href="/wiki/Ochratoxin_A" title="Ochratoxin A">Ochratoxin A</a></li> <li><a href="/wiki/Osthol" title="Osthol">Osthol</a></li> <li><a href="/wiki/Otilonium_bromide" title="Otilonium bromide">Otilonium bromide</a></li> <li><a href="/wiki/Paramethadione" title="Paramethadione">Paramethadione</a></li> <li><a href="/wiki/Phensuximide" title="Phensuximide">Phensuximide</a></li> <li><a href="/wiki/Pinaverium_bromide" title="Pinaverium bromide">Pinaverium bromide</a></li> <li><a href="/wiki/Prenylamine" title="Prenylamine">Prenylamine</a></li> <li><a href="/wiki/Rhynchophylline" title="Rhynchophylline">Rhynchophylline</a></li> <li><a href="/wiki/Sesamodil" title="Sesamodil">Sesamodil</a></li> <li><a href="/wiki/Silperisone" title="Silperisone">Silperisone</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Tetrandrine" title="Tetrandrine">Tetrandrine</a></li> <li><a href="/wiki/Tolperisone" title="Tolperisone">Tolperisone</a></li> <li><a href="/wiki/Trimethadione" title="Trimethadione">Trimethadione</a></li> <li><a href="/wiki/Valperinol" title="Valperinol">Valperinol</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium_channel_opener" title="Calcium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/L-type_calcium_channel" title="L-type calcium channel">L-type-selective</a>:</b> <a href="/wiki/Bay_K8644" title="Bay K8644">Bay K8644</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Potassium_channel" title="Potassium channel">Potassium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_potassium_channels" class="mw-redirect" title="Voltage-gated potassium channels"><abbr title="Voltage-gated potassium channels">VGKCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated potassium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/3,4-Diaminopyridine" class="mw-redirect" title="3,4-Diaminopyridine">3,4-Diaminopyridine (amifampridine)</a></li> <li><a href="/wiki/4-Aminopyridine" title="4-Aminopyridine">4-Aminopyridine (fampridine/dalfampridine)</a></li> <li><a href="/w/index.php?title=Adekalant&action=edit&redlink=1" class="new" title="Adekalant (page does not exist)">Adekalant</a></li> <li><a href="/wiki/Almokalant" title="Almokalant">Almokalant</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bretylium" title="Bretylium">Bretylium</a></li> <li><a href="/wiki/Bunaftine" title="Bunaftine">Bunaftine</a></li> <li><a href="/wiki/Charybdotoxin" title="Charybdotoxin">Charybdotoxin</a></li> <li><a href="/w/index.php?title=Clamikalant&action=edit&redlink=1" class="new" title="Clamikalant (page does not exist)">Clamikalant</a></li> <li><a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/w/index.php?title=Dalazatide&action=edit&redlink=1" class="new" title="Dalazatide (page does not exist)">Dalazatide</a></li> <li><a href="/wiki/Dendrotoxin" title="Dendrotoxin">Dendrotoxin</a></li> <li><a href="/wiki/Dofetilide" title="Dofetilide">Dofetilide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Hanatoxin" title="Hanatoxin">Hanatoxin</a></li> <li><a href="/wiki/HgeTx1" title="HgeTx1">HgeTx1</a></li> <li><a href="/wiki/HsTx1" title="HsTx1">HsTx1</a></li> <li><a href="/wiki/Ibutilide" title="Ibutilide">Ibutilide</a></li> <li><a href="/w/index.php?title=Inakalant&action=edit&redlink=1" class="new" title="Inakalant (page does not exist)">Inakalant</a></li> <li><a href="/wiki/Kaliotoxin" title="Kaliotoxin">Kaliotoxin</a></li> <li><a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/wiki/Lolitrem_B" title="Lolitrem B">Lolitrem B</a></li> <li><a href="/wiki/Maurotoxin" title="Maurotoxin">Maurotoxin</a></li> <li><a href="/wiki/Nifekalant" title="Nifekalant">Nifekalant</a></li> <li><a href="/w/index.php?title=Notoxin&action=edit&redlink=1" class="new" title="Notoxin (page does not exist)">Notoxin</a></li> <li><a href="/wiki/Paxilline" title="Paxilline">Paxilline</a></li> <li><a href="/w/index.php?title=Pinokalant&action=edit&redlink=1" class="new" title="Pinokalant (page does not exist)">Pinokalant</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/w/index.php?title=ShK-186&action=edit&redlink=1" class="new" title="ShK-186 (page does not exist)">ShK-186</a></li> <li><a href="/wiki/Sotalol" title="Sotalol">Sotalol</a></li> <li><a href="/wiki/Tedisamil" title="Tedisamil">Tedisamil</a></li> <li><a href="/w/index.php?title=Terikalant&action=edit&redlink=1" class="new" title="Terikalant (page does not exist)">Terikalant</a></li> <li><a href="/wiki/Tetraethylammonium" title="Tetraethylammonium">Tetraethylammonium</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/HERG" title="HERG">hERG</a> (KCNH2, K<sub>v</sub>11.1)-specific:</b> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/AmmTX3" title="AmmTX3">AmmTX3</a></li> <li><a href="/wiki/Astemizole" title="Astemizole">Astemizole</a></li> <li><a href="/wiki/Azaspiracid" title="Azaspiracid">Azaspiracid</a></li> <li><a href="/wiki/AZD1305" title="AZD1305">AZD1305</a></li> <li><a href="/wiki/Azimilide" title="Azimilide">Azimilide</a></li> <li><a href="/wiki/Bedaquiline" title="Bedaquiline">Bedaquiline</a></li> <li><a href="/wiki/BeKm-1_toxin" title="BeKm-1 toxin">BeKm-1</a></li> <li><a href="/wiki/BmTx3" title="BmTx3">BmTx3</a></li> <li><a href="/wiki/BRL-32872" title="BRL-32872">BRL-32872</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Cisapride" title="Cisapride">Cisapride</a></li> <li><a href="/wiki/Clarithromycin" title="Clarithromycin">Clarithromycin</a></li> <li><a href="/wiki/Darifenacin" title="Darifenacin">Darifenacin</a></li> <li><a href="/wiki/Dextropropoxyphene" title="Dextropropoxyphene">Dextropropoxyphene</a></li> <li><a href="/wiki/Diallyl_trisulfide" title="Diallyl trisulfide">Diallyl trisulfide</a></li> <li><a href="/wiki/Domperidone" title="Domperidone">Domperidone</a></li> <li><a href="/wiki/E-4031" title="E-4031">E-4031</a></li> <li><a href="/wiki/Ergtoxin" title="Ergtoxin">Ergtoxins</a></li> <li><a href="/wiki/Erythromycin" title="Erythromycin">Erythromycin</a></li> <li><a href="/wiki/Gigactonine" title="Gigactonine">Gigactonine</a></li> <li><a href="/wiki/Haloperidol" title="Haloperidol">Haloperidol</a></li> <li><a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Norpropoxyphene" title="Norpropoxyphene">Norpropoxyphene</a></li> <li><a href="/wiki/Orphenadrine" title="Orphenadrine">Orphenadrine</a></li> <li><a href="/wiki/Pimozide" title="Pimozide">Pimozide</a></li> <li><a href="/wiki/PNU-282,987" title="PNU-282,987">PNU-282,987</a></li> <li><a href="/wiki/Promethazine" title="Promethazine">Promethazine</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li> <li><a href="/wiki/Roxithromycin" title="Roxithromycin">Roxithromycin</a></li> <li><a href="/wiki/Sertindole" title="Sertindole">Sertindole</a></li> <li><a href="/wiki/Solifenacin" title="Solifenacin">Solifenacin</a></li> <li><a href="/wiki/Tamulotoxin" title="Tamulotoxin">Tamulotoxin</a></li> <li><a href="/wiki/Terodiline" title="Terodiline">Terodiline</a></li> <li><a href="/wiki/Terfenadine" title="Terfenadine">Terfenadine</a></li> <li><a href="/wiki/Thioridazine" title="Thioridazine">Thioridazine</a></li> <li><a href="/wiki/Tolterodine" title="Tolterodine">Tolterodine</a></li> <li><a href="/wiki/Vanoxerine" title="Vanoxerine">Vanoxerine</a></li> <li><a href="/wiki/Vernakalant" title="Vernakalant">Vernakalant</a></li></ul> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Linopirdine" title="Linopirdine">Linopirdine</a></li> <li><a href="/w/index.php?title=XE-991&action=edit&redlink=1" class="new" title="XE-991 (page does not exist)">XE-991</a></li> <li><a href="/wiki/Ssm_spooky_toxin" title="Ssm spooky toxin">Spooky toxin (SsTx)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/KCNQ" title="KCNQ">KCNQ (K<sub>v</sub>7)</a>-specific:</b> <a href="/wiki/Flupirtine" title="Flupirtine">Flupirtine</a></li> <li><a href="/wiki/Retigabine" title="Retigabine">Retigabine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Inwardly_rectifying_potassium_channel" class="mw-redirect" title="Inwardly rectifying potassium channel"><abbr title="Inwardly rectifying potassium channel">IRKs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Inwardly rectifying potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/wiki/Acetohexamide" title="Acetohexamide">Acetohexamide</a></li> <li><a href="/wiki/Carbutamide" title="Carbutamide">Carbutamide</a></li> <li><a href="/wiki/Chlorpropamide" title="Chlorpropamide">Chlorpropamide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide (glyburide)</a></li> <li><a href="/wiki/Glibornuride" title="Glibornuride">Glibornuride</a></li> <li><a href="/wiki/Glicaramide" title="Glicaramide">Glicaramide</a></li> <li><a href="/wiki/Gliclazide" title="Gliclazide">Gliclazide</a></li> <li><a href="/wiki/Glimepiride" title="Glimepiride">Glimepiride</a></li> <li><a href="/wiki/Glipizide" title="Glipizide">Glipizide</a></li> <li><a href="/wiki/Gliquidone" title="Gliquidone">Gliquidone</a></li> <li><a href="/wiki/Glisoxepide" title="Glisoxepide">Glisoxepide</a></li> <li><a href="/wiki/Glyclopyramide" title="Glyclopyramide">Glyclopyramide</a></li> <li><a href="/w/index.php?title=Glycyclamide&action=edit&redlink=1" class="new" title="Glycyclamide (page does not exist)">Glycyclamide</a></li> <li><a href="/wiki/Metahexamide" title="Metahexamide">Metahexamide</a></li> <li><a href="/wiki/Mitiglinide" title="Mitiglinide">Mitiglinide</a></li> <li><a href="/wiki/Nateglinide" title="Nateglinide">Nateglinide</a></li> <li><a href="/wiki/Repaglinide" title="Repaglinide">Repaglinide</a></li> <li><a href="/wiki/Tolazamide" title="Tolazamide">Tolazamide</a></li> <li><a href="/wiki/Tolbutamide" title="Tolbutamide">Tolbutamide</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/wiki/Barium" title="Barium">Barium</a></li> <li><a href="/wiki/Caramiphen" title="Caramiphen">Caramiphen</a></li> <li><a href="/wiki/Cloperastine" title="Cloperastine">Cloperastine</a></li> <li><a href="/wiki/Clozapine" title="Clozapine">Clozapine</a></li> <li><a href="/wiki/Dextromethorphan" title="Dextromethorphan">Dextromethorphan</a></li> <li><a href="/wiki/Ethosuximide" title="Ethosuximide">Ethosuximide</a></li> <li><a href="/wiki/Ifenprodil" title="Ifenprodil">Ifenprodil</a></li> <li><a href="/wiki/Tertiapin" title="Tertiapin">Tertiapin</a></li> <li><a href="/wiki/Tipepidine" title="Tipepidine">Tipepidine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/ATP-sensitive_potassium_channel" title="ATP-sensitive potassium channel"><abbr title="ATP-sensitive potassium channel">K<sub>ATP</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip ATP-sensitive potassium channel</span>-specific:</b> <a href="/w/index.php?title=Aprikalim&action=edit&redlink=1" class="new" title="Aprikalim (page does not exist)">Aprikalim</a></li> <li><a href="/wiki/Bimakalim" title="Bimakalim">Bimakalim</a></li> <li><a href="/wiki/Cromakalim" title="Cromakalim">Cromakalim</a></li> <li><a href="/wiki/Diazoxide" title="Diazoxide">Diazoxide</a></li> <li><a href="/w/index.php?title=Emakalim&action=edit&redlink=1" class="new" title="Emakalim (page does not exist)">Emakalim</a></li> <li><a href="/wiki/Levcromakalim" class="mw-redirect" title="Levcromakalim">Levcromakalim</a></li> <li><a href="/w/index.php?title=Mazokalim&action=edit&redlink=1" class="new" title="Mazokalim (page does not exist)">Mazokalim</a></li> <li><a href="/wiki/Minoxidil" title="Minoxidil">Minoxidil</a></li> <li><a href="/wiki/Minoxidil_sulfate" title="Minoxidil sulfate">Minoxidil sulfate</a></li> <li><a href="/w/index.php?title=Naminidil&action=edit&redlink=1" class="new" title="Naminidil (page does not exist)">Naminidil</a></li> <li><a href="/wiki/Nicorandil" title="Nicorandil">Nicorandil</a></li> <li><a href="/wiki/Pinacidil" title="Pinacidil">Pinacidil</a></li> <li><a href="/w/index.php?title=Rilmakalim&action=edit&redlink=1" class="new" title="Rilmakalim (page does not exist)">Rilmakalim</a></li> <li><a href="/w/index.php?title=Sarakalim&action=edit&redlink=1" class="new" title="Sarakalim (page does not exist)">Sarakalim</a></li></ul> <ul><li><b><a href="/wiki/G_protein-coupled_inwardly_rectifying_potassium_channel" title="G protein-coupled inwardly rectifying potassium channel"><abbr title="G protein-coupled inwardly rectifying potassium channel">GIRK</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip G protein-coupled inwardly rectifying potassium channel</span>-specific:</b> <a href="/w/index.php?title=ML-297&action=edit&redlink=1" class="new" title="ML-297 (page does not exist)">ML-297 (VU0456810)</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_potassium_channel" title="Calcium-activated potassium channel"><abbr title="Calcium-activated potassium channel">K<sub>Ca</sub></abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Alcohol_(drug)" title="Alcohol (drug)">Ethanol (alcohol)</a></li> <li><a href="/wiki/GAL-021" class="mw-redirect" title="GAL-021">GAL-021</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><b><a href="/wiki/BK_channel" title="BK channel">BK<sub>Ca</sub></a>-specific:</b> <a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/wiki/Nimesulide" title="Nimesulide">Nimesulide</a></li> <li><a href="/wiki/Rottlerin" title="Rottlerin">Rottlerin (mallotoxin)</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Tandem_pore_domain_potassium_channel" class="mw-redirect" title="Tandem pore domain potassium channel"><abbr title="Tandem pore domain potassium channel">K2Ps</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Tandem pore domain potassium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_blocker" title="Potassium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/12-O-Tetradecanoylphorbol-13-acetate" title="12-O-Tetradecanoylphorbol-13-acetate">12-O-Tetradecanoylphorbol-13-acetate</a></li> <li><a href="/wiki/Arachidonic_acid" title="Arachidonic acid">Arachidonic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Norfluoxetine" class="mw-redirect" title="Norfluoxetine">Norfluoxetine</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Potassium_channel_opener" title="Potassium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Riluzole" title="Riluzole">Riluzole</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Sodium_channel" title="Sodium channel">Sodium</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Voltage-gated_sodium_channels" class="mw-redirect" title="Voltage-gated sodium channels"><abbr title="Voltage-gated sodium channels">VGSCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Voltage-gated sodium channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Antianginals:</i> <a href="/wiki/Ranolazine" title="Ranolazine">Ranolazine</a></li></ul> <ul><li><i>Antiarrhythmics (class I):</i> <a href="/wiki/Ajmaline" title="Ajmaline">Ajmaline</a></li> <li><a href="/wiki/Aprindine" title="Aprindine">Aprindine</a></li> <li><a href="/wiki/Disopyramide" title="Disopyramide">Disopyramide</a></li> <li><a href="/wiki/Dronedarone" title="Dronedarone">Dronedarone</a></li> <li><a href="/wiki/Encainide" title="Encainide">Encainide</a></li> <li><a href="/wiki/Flecainide" title="Flecainide">Flecainide</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Lorajmine" title="Lorajmine">Lorajmine</a></li> <li><a href="/wiki/Lorcainide" title="Lorcainide">Lorcainide</a></li> <li><a href="/wiki/Mexiletine" title="Mexiletine">Mexiletine</a></li> <li><a href="/wiki/Moracizine" title="Moracizine">Moricizine</a></li> <li><a href="/wiki/Pilsicainide" title="Pilsicainide">Pilsicainide</a></li> <li><a href="/wiki/Prajmaline" title="Prajmaline">Prajmaline</a></li> <li><a href="/wiki/Procainamide" title="Procainamide">Procainamide</a></li> <li><a href="/wiki/Propafenone" title="Propafenone">Propafenone</a></li> <li><a href="/wiki/Quinidine" title="Quinidine">Quinidine</a></li> <li><a href="/wiki/Sparteine" title="Sparteine">Sparteine</a></li> <li><a href="/wiki/Tocainide" title="Tocainide">Tocainide</a></li></ul> <ul><li><i>Anticonvulsants:</i> <a href="/w/index.php?title=Acetylpheneturide&action=edit&redlink=1" class="new" title="Acetylpheneturide (page does not exist)">Acetylpheneturide</a></li> <li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Cenobamate" title="Cenobamate">Cenobamate</a></li> <li><a href="/wiki/Chlorphenacemide" title="Chlorphenacemide">Chlorphenacemide</a></li> <li><a href="/w/index.php?title=Elpetrigine&action=edit&redlink=1" class="new" title="Elpetrigine (page does not exist)">Elpetrigine</a></li> <li><a href="/wiki/Eslicarbazepine_acetate" title="Eslicarbazepine acetate">Eslicarbazepine acetate</a></li> <li><a href="/wiki/Ethotoin" title="Ethotoin">Ethotoin</a></li> <li><a href="/wiki/Fosphenytoin" title="Fosphenytoin">Fosphenytoin</a></li> <li><a href="/wiki/Lamotrigine" title="Lamotrigine">Lamotrigine</a></li> <li><a href="/wiki/Lacosamide" title="Lacosamide">Lacosamide</a></li> <li><a href="/wiki/Licarbazepine" title="Licarbazepine">Licarbazepine</a></li> <li><a href="/wiki/Mephenytoin" title="Mephenytoin">Mephenytoin</a></li> <li><a href="/wiki/Oxcarbazepine" title="Oxcarbazepine">Oxcarbazepine</a></li> <li><a href="/wiki/Oxitriptyline" title="Oxitriptyline">Oxitriptyline</a></li> <li><a href="/wiki/Phenacemide" title="Phenacemide">Phenacemide</a></li> <li><a href="/wiki/Pheneturide" title="Pheneturide">Pheneturide</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/Rufinamide" title="Rufinamide">Rufinamide</a></li> <li><a href="/w/index.php?title=Sipatrigine&action=edit&redlink=1" class="new" title="Sipatrigine (page does not exist)">Sipatrigine</a></li> <li><a href="/wiki/Topiramate" title="Topiramate">Topiramate</a></li> <li><a href="/wiki/Sodium_valproate" class="mw-redirect" title="Sodium valproate">Sodium valproate</a></li> <li><a href="/wiki/Valnoctamide" title="Valnoctamide">Valnoctamide</a></li> <li><a href="/wiki/Valproate_pivoxil" title="Valproate pivoxil">Valproate pivoxil</a></li> <li><a href="/wiki/Valproate_semisodium" class="mw-redirect" title="Valproate semisodium">Valproate semisodium</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li> <li><a href="/wiki/Valpromide" title="Valpromide">Valpromide</a></li> <li><a href="/wiki/Zonisamide" title="Zonisamide">Zonisamide</a></li></ul> <ul><li><i>Local anesthetics:</i> <a href="/wiki/3-(p-Fluorobenzoyloxy)tropane" title="3-(p-Fluorobenzoyloxy)tropane"><i>p</i>FBT</a></li> <li><a href="/wiki/Amylocaine" title="Amylocaine">Amylocaine</a></li> <li><a href="/wiki/Articaine" title="Articaine">Articaine</a></li> <li><a href="/wiki/Benzocaine" title="Benzocaine">Benzocaine</a></li> <li><a href="/wiki/Bupivacaine" title="Bupivacaine">Bupivacaine</a> (<a href="/wiki/Levobupivacaine" title="Levobupivacaine">Levobupivacaine</a>, <a href="/wiki/Ropivacaine" title="Ropivacaine">Ropivacaine</a>)</li> <li><a href="/wiki/Butacaine" title="Butacaine">Butacaine</a></li> <li><a href="/wiki/Butamben" title="Butamben">Butamben</a></li> <li><a href="/wiki/Chloroprocaine" title="Chloroprocaine">Chloroprocaine</a></li> <li><a href="/wiki/Cinchocaine" title="Cinchocaine">Cinchocaine</a></li> <li><a href="/wiki/Cocaine" title="Cocaine">Cocaine</a></li> <li><a href="/wiki/Cyclomethycaine" title="Cyclomethycaine">Cyclomethycaine</a></li> <li><a href="/wiki/Dimethocaine" title="Dimethocaine">Dimethocaine</a></li> <li><a href="/wiki/Diphenhydramine" title="Diphenhydramine">Diphenhydramine</a></li> <li><a href="/wiki/Etidocaine" title="Etidocaine">Etidocaine</a></li> <li><a href="/wiki/Hexylcaine" title="Hexylcaine">Hexylcaine</a></li> <li><a href="/wiki/Iontocaine" title="Iontocaine">Iontocaine</a></li> <li><a href="/wiki/Lidocaine" title="Lidocaine">Lidocaine</a></li> <li><a href="/wiki/Mepivacaine" title="Mepivacaine">Mepivacaine</a></li> <li><a href="/wiki/Meprylcaine" title="Meprylcaine">Meprylcaine</a></li> <li><a href="/wiki/Metabutoxycaine" title="Metabutoxycaine">Metabutoxycaine</a></li> <li><a href="/wiki/Orthocaine" title="Orthocaine">Orthocaine</a></li> <li><a href="/wiki/Piperocaine" title="Piperocaine">Piperocaine</a></li> <li><a href="/wiki/Prilocaine" title="Prilocaine">Prilocaine</a></li> <li><a href="/wiki/Procaine" title="Procaine">Procaine</a></li> <li><a href="/wiki/Propoxycaine" title="Propoxycaine">Propoxycaine</a></li> <li><a href="/wiki/Proxymetacaine" title="Proxymetacaine">Proxymetacaine</a></li> <li><a href="/wiki/Risocaine" title="Risocaine">Risocaine</a></li> <li><a href="/wiki/Tetracaine" title="Tetracaine">Tetracaine</a></li> <li><a href="/wiki/Trimecaine" title="Trimecaine">Trimecaine</a></li></ul> <ul><li><i>Analgesics:</i> <a href="/w/index.php?title=AZD-3161&action=edit&redlink=1" class="new" title="AZD-3161 (page does not exist)">AZD-3161</a></li> <li><a href="/wiki/DSP-2230" title="DSP-2230">DSP-2230</a></li> <li><a href="/wiki/Funapide" title="Funapide">Funapide</a></li> <li><a href="/w/index.php?title=GDC-0276&action=edit&redlink=1" class="new" title="GDC-0276 (page does not exist)">GDC-0276</a></li> <li><a href="/w/index.php?title=NKTR-171&action=edit&redlink=1" class="new" title="NKTR-171 (page does not exist)">NKTR-171</a></li> <li><a href="/w/index.php?title=PF-04531083&action=edit&redlink=1" class="new" title="PF-04531083 (page does not exist)">PF-04531083</a></li> <li><a href="/wiki/PF-05089771" title="PF-05089771">PF-05089771</a></li> <li><a href="/wiki/Ralfinamide" title="Ralfinamide">Ralfinamide</a></li> <li><a href="/wiki/Raxatrigine" class="mw-redirect" title="Raxatrigine">Raxatrigine</a></li> <li><a href="/w/index.php?title=RG7893&action=edit&redlink=1" class="new" title="RG7893 (page does not exist)">RG7893 (GDC-0287)</a></li> <li><a href="/wiki/Suzetrigine" title="Suzetrigine">Suzetrigine</a></li></ul> <ul><li><i>Toxins:</i> <a href="/wiki/Conotoxin" title="Conotoxin">Conotoxins</a></li> <li><a href="/wiki/Neosaxitoxin" title="Neosaxitoxin">Neosaxitoxin</a></li> <li><a href="/wiki/Saxitoxin" title="Saxitoxin">Saxitoxin</a></li> <li><a href="/wiki/Tetrodotoxin" title="Tetrodotoxin">Tetrodotoxin</a></li> <li><a href="/wiki/Zetekitoxin_AB" title="Zetekitoxin AB">Zetekitoxin AB</a></li></ul> <ul><li><i>Others:</i> <a href="/wiki/Buprenorphine" title="Buprenorphine">Buprenorphine</a></li> <li><a href="/wiki/Evenamide" title="Evenamide">Evenamide</a></li> <li><a href="/wiki/Menthol" title="Menthol">Menthol</a> (<a href="/wiki/Mentha" title="Mentha">mint</a>)</li> <li><a href="/wiki/Safinamide" title="Safinamide">Safinamide</a></li> <li><a href="/wiki/Tricyclic_antidepressant" title="Tricyclic antidepressant">Tricyclic antidepressants</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Aconitine" title="Aconitine">Aconitine</a></li> <li>Atracotoxins (<a href="/wiki/Omega-Atracotoxin" title="Omega-Atracotoxin">ω-Atracotoxin</a>, <a href="/wiki/Robustoxin" class="mw-redirect" title="Robustoxin">Robustoxin</a>, <a href="/wiki/Versutoxin" title="Versutoxin">Versutoxin</a>)</li> <li><a href="/wiki/Batrachotoxin" title="Batrachotoxin">Batrachotoxin</a></li> <li><a href="/wiki/Ciguatoxin" title="Ciguatoxin">Ciguatoxins</a></li> <li><a href="/wiki/Grayanotoxin" title="Grayanotoxin">Grayanotoxins</a></li> <li><a href="/wiki/Poneratoxin" title="Poneratoxin">Poneratoxin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Epithelial_sodium_channel" title="Epithelial sodium channel"><abbr title="Epithelial sodium channel">ENaC</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Epithelial sodium channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Benzamil" title="Benzamil">Benzamil</a></li> <li><a href="/wiki/Triamterene" title="Triamterene">Triamterene</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_opener" title="Sodium channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=Solnatide&action=edit&redlink=1" class="new" title="Solnatide (page does not exist)">Solnatide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Acid-sensing_ion_channel" title="Acid-sensing ion channel"><abbr title="Acid-sensing ion channel">ASICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Acid-sensing ion channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Sodium_channel_blocker" title="Sodium channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=A-317567&action=edit&redlink=1" class="new" title="A-317567 (page does not exist)">A-317567</a></li> <li><a href="/wiki/Amiloride" title="Amiloride">Amiloride</a></li> <li><a href="/wiki/Aspirin" title="Aspirin">Aspirin</a></li> <li><a href="/wiki/Ibuprofen" title="Ibuprofen">Ibuprofen</a></li> <li><a href="/w/index.php?title=PcTX1&action=edit&redlink=1" class="new" title="PcTX1 (page does not exist)">PcTX1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Chloride_channel" title="Chloride channel">Chloride</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Calcium-activated_chloride_channel" class="mw-redirect" title="Calcium-activated chloride channel"><abbr title="Calcium-activated chloride channel">CaCCs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Calcium-activated chloride channel</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Crofelemer" title="Crofelemer">Crofelemer</a></li> <li><a href="/wiki/DIDS" title="DIDS">DIDS</a></li> <li><a href="/wiki/Ethacrynic_acid" class="mw-redirect" title="Ethacrynic acid">Ethacrynic acid</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Fluoxetine" title="Fluoxetine">Fluoxetine</a></li> <li><a href="/wiki/Furosemide" title="Furosemide">Furosemide</a></li> <li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Mefloquine" title="Mefloquine">Mefloquine</a></li> <li><a href="/wiki/Mibefradil" title="Mibefradil">Mibefradil</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carbachol" title="Carbachol">Carbachol</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Cystic_fibrosis_transmembrane_conductance_regulator" title="Cystic fibrosis transmembrane conductance regulator"><abbr title="Cystic fibrosis transmembrane conductance regulator">CFTR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Cystic fibrosis transmembrane conductance regulator</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glibenclamide" title="Glibenclamide">Glibenclamide</a></li> <li><a href="/wiki/Lonidamine" title="Lonidamine">Lonidamine</a></li> <li><a href="/wiki/Piretanide" title="Piretanide">Piretanide</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_opener" title="Chloride channel opener">Activators</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/w/index.php?title=1,7-Phenanthroline&action=edit&redlink=1" class="new" title="1,7-Phenanthroline (page does not exist)">1,7-Phenanthroline</a></li> <li><a href="/wiki/1,10-Phenanthroline" title="1,10-Phenanthroline">1,10-Phenanthroline</a></li> <li><a href="/w/index.php?title=4,7-Phenanthroline&action=edit&redlink=1" class="new" title="4,7-Phenanthroline (page does not exist)">4,7-Phenanthroline</a></li> <li><a href="/w/index.php?title=7,8-Benzoquinoline&action=edit&redlink=1" class="new" title="7,8-Benzoquinoline (page does not exist)">7,8-Benzoquinoline</a></li> <li><a href="/wiki/Ivacaftor" title="Ivacaftor">Ivacaftor</a></li> <li><a href="/wiki/Phenanthridine" title="Phenanthridine">Phenanthridine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Chloride_channel_blocker" title="Chloride channel blocker">Blockers</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bumetanide" title="Bumetanide">Bumetanide</a></li> <li><a href="/wiki/Flufenamic_acid" title="Flufenamic acid">Flufenamic acid</a></li> <li><a href="/wiki/Meclofenamic_acid" title="Meclofenamic acid">Meclofenamic acid</a></li> <li><a href="/wiki/Mefenamic_acid" title="Mefenamic acid">Mefenamic acid</a></li> <li><a href="/wiki/Mepacrine" title="Mepacrine">Mepacrine</a></li> <li><a href="/wiki/Niflumic_acid" title="Niflumic acid">Niflumic acid</a></li> <li><a href="/w/index.php?title=Talniflumate&action=edit&redlink=1" class="new" title="Talniflumate (page does not exist)">Talniflumate</a></li> <li><a href="/wiki/Tolfenamic_acid" title="Tolfenamic acid">Tolfenamic acid</a></li> <li><a href="/wiki/Trifluoperazine" title="Trifluoperazine">Trifluoperazine</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Transient_receptor_potential_channels" class="mw-redirect" title="Transient receptor potential channels"><abbr title="Transient receptor potential channels">TRPs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Transient receptor potential channels</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:5em;;text-align:center;"><a href="/wiki/Ligand_gated_ion_channels" class="mw-redirect" title="Ligand gated ion channels"><abbr title="Ligand gated ion channels">LGICs</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Ligand gated ion channels</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:Pharmacomodulation" title="Template:Pharmacomodulation">here</a> instead.</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div><i><b>See also:</b> <a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a> • <a href="/wiki/Template:Transient_receptor_potential_channel_modulators" title="Template:Transient receptor potential channel modulators">Transient receptor potential channel modulators</a></i></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Mineralocorticoid_receptor_modulators767" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Mineralocorticoid_receptor_modulators" title="Template:Mineralocorticoid receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Mineralocorticoid_receptor_modulators" title="Template talk:Mineralocorticoid receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Mineralocorticoid_receptor_modulators" title="Special:EditPage/Template:Mineralocorticoid receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Mineralocorticoid_receptor_modulators767" style="font-size:114%;margin:0 4em"><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor">Mineralocorticoid receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Mineralocorticoid_receptor" title="Mineralocorticoid receptor"><abbr title="Mineralocorticoid receptor">MR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Mineralocorticoid receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Agonists</th><td class="navbox-list-with-group navbox-list navbox-odd" style="padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/11-Dehydrocorticosterone" title="11-Dehydrocorticosterone">11-Dehydrocorticosterone (11-oxocorticosterone, 17-deoxycortisone)</a> <ul><li><a href="/w/index.php?title=11-Dehydrocorticosterone_acetate&action=edit&redlink=1" class="new" title="11-Dehydrocorticosterone acetate (page does not exist)">11-Dehydrocorticosterone acetate</a></li></ul></li> <li><a href="/wiki/11-Deoxycorticosterone" title="11-Deoxycorticosterone">11-Deoxycorticosterone (desoxycortone, deoxycortone, desoxycorticosterone)</a> <ul><li><a href="/wiki/List_of_corticosteroid_esters#Desoxycortone_esters" title="List of corticosteroid esters">Desoxycortone esters</a></li></ul></li> <li><a href="/wiki/11-Deoxycortisol" title="11-Deoxycortisol">11-Deoxycortisol (cortodoxone, cortexolone)</a> <ul><li><a href="/wiki/Cortifen" title="Cortifen">Cortifen (cortiphen, kortifen)</a></li> <li><a href="/w/index.php?title=Cortodoxone_acetate&action=edit&redlink=1" class="new" title="Cortodoxone acetate (page does not exist)">Cortodoxone acetate</a></li></ul></li> <li><a href="/wiki/11%CE%B2-Hydroxyprogesterone" title="11β-Hydroxyprogesterone">11β-Hydroxyprogesterone</a></li> <li><a href="/w/index.php?title=16%CE%B1,18-Dihydroxy-11-deoxycorticosterone&action=edit&redlink=1" class="new" title="16α,18-Dihydroxy-11-deoxycorticosterone (page does not exist)">16α,18-Dihydroxy-11-deoxycorticosterone</a></li> <li><a href="/w/index.php?title=17%CE%B1-Hydroxyaldosterone&action=edit&redlink=1" class="new" title="17α-Hydroxyaldosterone (page does not exist)">17α-Hydroxyaldosterone</a></li> <li><a href="/wiki/18-Hydroxy-11-deoxycorticosterone" title="18-Hydroxy-11-deoxycorticosterone">18-Hydroxy-11-deoxycorticosterone</a></li> <li><a href="/wiki/19-Norprogesterone" title="19-Norprogesterone">19-Norprogesterone</a></li> <li><a href="/wiki/Aldosterone" title="Aldosterone">Aldosterone</a></li> <li><a href="/wiki/Corticosterone" title="Corticosterone">Corticosterone</a> <ul><li><a href="/w/index.php?title=Corticosterone_acetate&action=edit&redlink=1" class="new" title="Corticosterone acetate (page does not exist)">Corticosterone acetate</a></li> <li><a href="/w/index.php?title=Corticosterone_benzoate&action=edit&redlink=1" class="new" title="Corticosterone benzoate (page does not exist)">Corticosterone benzoate</a></li></ul></li> <li><a href="/wiki/Cortisol" title="Cortisol">Cortisol</a> (<a href="/wiki/Hydrocortisone" title="Hydrocortisone">hydrocortisone</a>) <ul><li><a href="/wiki/Benzodrocortisone" title="Benzodrocortisone">Benzodrocortisone (hydrocortisone benzoate)</a></li> <li><a href="/wiki/Hydrocortamate" title="Hydrocortamate">Hydrocortamate (hydrocortisone diethylaminoacetate)</a></li> <li><a href="/wiki/List_of_corticosteroid_esters#Hydrocortisone_esters" title="List of corticosteroid esters">Hydrocortisone esters</a></li></ul></li> <li><a href="/wiki/Cortisone" title="Cortisone">Cortisone</a> <ul><li><a href="/wiki/Cortisone_acetate" title="Cortisone acetate">Cortisone acetate</a></li></ul></li> <li><a href="/wiki/Fludrocortisone" title="Fludrocortisone">Fludrocortisone (fludrocortone)</a> <ul><li><a href="/wiki/Fludrocortisone_acetate" class="mw-redirect" title="Fludrocortisone acetate">Fludrocortisone acetate</a></li></ul></li> <li><a href="/wiki/Mometasone" title="Mometasone">Mometasone</a> <ul><li><a href="/wiki/Mometasone_furoate" class="mw-redirect" title="Mometasone furoate">Mometasone furoate</a></li></ul></li> <li><a href="/wiki/Prednisolone" title="Prednisolone">Prednisolone</a> <ul><li><a href="/wiki/Prednazate" title="Prednazate">Prednazate</a></li> <li><a href="/wiki/Prednazoline" title="Prednazoline">Prednazoline</a></li> <li><a href="/wiki/Prednicarbate" title="Prednicarbate">Prednicarbate (prednisolone ethylcarbonate propionate)</a></li> <li><a href="/wiki/Prednimustine" title="Prednimustine">Prednimustine</a></li> <li><a href="/wiki/Prednisolamate" title="Prednisolamate">Prednisolamate (prednisolone diethylaminoacetate)</a></li> <li><a href="/wiki/List_of_corticosteroid_esters#Prednisolone_esters" title="List of corticosteroid esters">Prednisolone esters</a></li></ul></li> <li><a href="/wiki/Prednisone" title="Prednisone">Prednisone</a> <ul><li><a href="/wiki/List_of_corticosteroid_esters#Prednisone_esters" title="List of corticosteroid esters">Prednisone esters</a></li></ul></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:6em;;text-align:center">Antagonists</th><td class="navbox-list-with-group navbox-list navbox-even" style="padding:0"><div style="padding:0 0.25em"> <ul><li><i>Steroidal:</i> <a href="/wiki/6%CE%B2-Hydroxy-7%CE%B1-thiomethylspironolactone" title="6β-Hydroxy-7α-thiomethylspironolactone">6β-Hydroxy-7α-thiomethylspironolactone</a></li> <li><a href="/w/index.php?title=7%CE%B1-Acetylthio-17%CE%B1-hydroxyprogesterone&action=edit&redlink=1" class="new" title="7α-Acetylthio-17α-hydroxyprogesterone (page does not exist)">7α-Acetylthio-17α-hydroxyprogesterone</a></li> <li><a href="/wiki/7%CE%B1-Thiomethylspironolactone" title="7α-Thiomethylspironolactone">7α-Thiomethylspironolactone (SC-26519)</a></li> <li><a href="/wiki/7%CE%B1-Thioprogesterone" title="7α-Thioprogesterone">7α-Thioprogesterone (SC-8365)</a></li> <li><a href="/wiki/7%CE%B1-Thiospironolactone" title="7α-Thiospironolactone">7α-Thiospironolactone (SC-24813)</a></li> <li><a href="/wiki/16%CE%B1-Hydroxyprogesterone" title="16α-Hydroxyprogesterone">16α-Hydroxyprogesterone</a></li> <li><a href="/wiki/17%CE%B1-Hydroxyprogesterone" title="17α-Hydroxyprogesterone">17α-Hydroxyprogesterone (hydroxyprogesterone)</a></li> <li><a href="/wiki/18-Deoxyaldosterone" title="18-Deoxyaldosterone">18-Deoxyaldosterone</a></li> <li><a href="/w/index.php?title=18,19-Dinorprogesterone&action=edit&redlink=1" class="new" title="18,19-Dinorprogesterone (page does not exist)">18,19-Dinorprogesterone</a></li> <li><a href="/wiki/Potassium_canrenoate" title="Potassium canrenoate">Canrenoate potassium (potassium canrenoate)</a></li> <li><a href="/wiki/Canrenoic_acid" title="Canrenoic acid">Canrenoic acid (canrenoate)</a></li> <li><a href="/wiki/Canrenone" title="Canrenone">Canrenone (canrenoate y-lactone)</a></li> <li><a href="/wiki/Dicirenone" title="Dicirenone">Dicirenone</a></li> <li><a href="/wiki/Dimethisterone" title="Dimethisterone">Dimethisterone</a></li> <li><a href="/wiki/Drospirenone" title="Drospirenone">Drospirenone</a></li> <li><a href="/wiki/Dydrogesterone" title="Dydrogesterone">Dydrogesterone</a></li> <li><a href="/wiki/Eplerenone" title="Eplerenone">Eplerenone</a></li> <li><a href="/wiki/Gestodene" title="Gestodene">Gestodene</a></li> <li><a href="/wiki/Guggulsterone" title="Guggulsterone">Guggulsterone</a></li> <li><a href="/wiki/Hydroxyprogesterone_caproate" title="Hydroxyprogesterone caproate">Hydroxyprogesterone caproate</a></li> <li><a href="/wiki/Medrogestone" title="Medrogestone">Medrogestone</a></li> <li><a href="/wiki/Mespirenone" title="Mespirenone">Mespirenone</a></li> <li><a href="/wiki/Metribolone" title="Metribolone">Metribolone</a></li> <li><a href="/wiki/Mexrenoate_potassium" title="Mexrenoate potassium">Mexrenoate potassium</a></li> <li><a href="/wiki/Mexrenoic_acid" title="Mexrenoic acid">Mexrenoic acid (mexrenoate)</a></li> <li><a href="/wiki/Mexrenone" title="Mexrenone">Mexrenone</a></li> <li><a href="/wiki/Oxprenoic_acid" title="Oxprenoic acid">Oxprenoic acid (oxprenoate)</a></li> <li><a href="/wiki/Oxprenoate_potassium" title="Oxprenoate potassium">Oxprenoate potassium (RU-28318)</a></li> <li><a href="/wiki/Pregnenolone" title="Pregnenolone">Pregnenolone</a></li> <li><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></li> <li><a href="/wiki/Prorenoate_potassium" title="Prorenoate potassium">Prorenoate potassium</a></li> <li><a href="/wiki/Prorenoic_acid" title="Prorenoic acid">Prorenoic acid (prorenoate)</a></li> <li><a href="/wiki/Prorenone" title="Prorenone">Prorenone</a></li> <li><a href="/w/index.php?title=RO-14-9012&action=edit&redlink=1" class="new" title="RO-14-9012 (page does not exist)">RO-14-9012</a></li> <li><a href="/w/index.php?title=RU-26752&action=edit&redlink=1" class="new" title="RU-26752 (page does not exist)">RU-26752</a></li> <li><a href="/wiki/SC-5233" title="SC-5233">SC-5233 (spirolactone)</a></li> <li><a href="/wiki/SC-8109" title="SC-8109">SC-8109</a></li> <li><a href="/w/index.php?title=SC-11927&action=edit&redlink=1" class="new" title="SC-11927 (page does not exist)">SC-11927 (CS-1)</a></li> <li><a href="/w/index.php?title=SC-19886&action=edit&redlink=1" class="new" title="SC-19886 (page does not exist)">SC-19886</a></li> <li><a href="/w/index.php?title=SC-27169&action=edit&redlink=1" class="new" title="SC-27169 (page does not exist)">SC-27169</a></li> <li><a href="/wiki/Spirorenone" title="Spirorenone">Spirorenone</a></li> <li><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></li> <li><a href="/wiki/Spiroxasone" title="Spiroxasone">Spiroxasone</a></li> <li><a href="/wiki/Tibolone" title="Tibolone">Tibolone</a></li> <li><a href="/wiki/Trimegestone" title="Trimegestone">Trimegestone</a></li> <li><a href="/wiki/Vamorolone" title="Vamorolone">Vamorolone</a></li> <li><a href="/w/index.php?title=ZK-91587&action=edit&redlink=1" class="new" title="ZK-91587 (page does not exist)">ZK-91587</a></li> <li><a href="/w/index.php?title=ZK-97894&action=edit&redlink=1" class="new" title="ZK-97894 (page does not exist)">ZK-97894</a></li></ul> <ul><li><i>Nonsteroidal:</i> <a class="mw-selflink selflink">Amlodipine</a></li> <li><a href="/wiki/Apararenone" title="Apararenone">Apararenone</a></li> <li><a href="/wiki/Benidipine" title="Benidipine">Benidipine</a></li> <li><a href="/w/index.php?title=BR-4628&action=edit&redlink=1" class="new" title="BR-4628 (page does not exist)">BR-4628</a></li> <li><a href="/wiki/Esaxerenone" title="Esaxerenone">Esaxerenone</a></li> <li><a href="/wiki/Felodipine" title="Felodipine">Felodipine</a></li> <li><a href="/wiki/Finerenone" title="Finerenone">Finerenone</a></li> <li><a href="/wiki/Miricorilant" title="Miricorilant">Miricorilant (CORT-118335)</a></li> <li><a href="/wiki/Nifedipine" title="Nifedipine">Nifedipine</a></li> <li><a href="/wiki/Nimodipine" title="Nimodipine">Nimodipine</a></li> <li><a href="/wiki/Nitrendipine" title="Nitrendipine">Nitrendipine</a></li> <li><a href="/wiki/Ocedurenone" title="Ocedurenone">Ocedurenone</a></li> <li><a href="/w/index.php?title=PF-03882845&action=edit&redlink=1" class="new" title="PF-03882845 (page does not exist)">PF-03882845</a></li> <li><a href="/w/index.php?title=SM-368229&action=edit&redlink=1" class="new" title="SM-368229 (page does not exist)">SM-368229</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></dd> <dd><a href="/wiki/Template:Mineralocorticoids_and_antimineralocorticoids" title="Template:Mineralocorticoids and antimineralocorticoids">Mineralocorticoids and antimineralocorticoids</a></dd> <dd><a href="/wiki/Template:Glucocorticoid_receptor_modulators" title="Template:Glucocorticoid receptor modulators">Glucocorticoid receptor modulators</a></dd> <dd><a href="/wiki/List_of_corticosteroids" title="List of corticosteroids">List of corticosteroids</a></dd></dl> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Xenobiotic-sensing_receptor_modulators953" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Xenobiotic-sensing_receptor_modulators" title="Template:Xenobiotic-sensing receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Xenobiotic-sensing_receptor_modulators" title="Template talk:Xenobiotic-sensing receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Xenobiotic-sensing_receptor_modulators" title="Special:EditPage/Template:Xenobiotic-sensing receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Xenobiotic-sensing_receptor_modulators953" style="font-size:114%;margin:0 4em"><a href="/wiki/Xenobiotic-sensing_receptor" title="Xenobiotic-sensing receptor">Xenobiotic-sensing receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Constitutive_androstane_receptor" title="Constitutive androstane receptor"><abbr title="Constitutive androstane receptor">CAR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Constitutive androstane receptor</span></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=6,7-Dimethylesculetin&action=edit&redlink=1" class="new" title="6,7-Dimethylesculetin (page does not exist)">6,7-Dimethylesculetin</a></li> <li><a href="/wiki/Amiodarone" title="Amiodarone">Amiodarone</a></li> <li><a href="/wiki/Artemisinin" title="Artemisinin">Artemisinin</a></li> <li><a href="/w/index.php?title=Benfuracarb&action=edit&redlink=1" class="new" title="Benfuracarb (page does not exist)">Benfuracarb</a></li> <li><a href="/wiki/Carbamazepine" title="Carbamazepine">Carbamazepine</a></li> <li><a href="/wiki/Carvedilol" title="Carvedilol">Carvedilol</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Chrysin" title="Chrysin">Chrysin</a></li> <li><a href="/w/index.php?title=CITCO_(drug)&action=edit&redlink=1" class="new" title="CITCO (drug) (page does not exist)">CITCO</a></li> <li><a href="/wiki/Clotrimazole" title="Clotrimazole">Clotrimazole</a></li> <li><a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">Cyclophosphamide</a></li> <li><a href="/wiki/Cypermethrin" title="Cypermethrin">Cypermethrin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a> (<a href="/wiki/Prasterone" title="Prasterone">prasterone</a>)</li> <li><a href="/wiki/Efavirenz" title="Efavirenz">Efavirenz</a></li> <li><a href="/wiki/Ellagic_acid" title="Ellagic acid">Ellagic acid</a></li> <li><a href="/wiki/Griseofulvin" title="Griseofulvin">Griseofulvin</a></li> <li><a href="/wiki/Methoxychlor" title="Methoxychlor">Methoxychlor</a></li> <li><a href="/wiki/Mifepristone" title="Mifepristone">Mifepristone</a></li> <li><a href="/wiki/Nefazodone" title="Nefazodone">Nefazodone</a></li> <li><a href="/wiki/Nevirapine" title="Nevirapine">Nevirapine</a></li> <li><a href="/wiki/Nicardipine" title="Nicardipine">Nicardipine</a></li> <li><a href="/w/index.php?title=Octicizer&action=edit&redlink=1" class="new" title="Octicizer (page does not exist)">Octicizer</a></li> <li><a href="/wiki/Permethrin" title="Permethrin">Permethrin</a></li> <li><a href="/wiki/Phenobarbital" title="Phenobarbital">Phenobarbital</a></li> <li><a href="/wiki/Phenytoin" title="Phenytoin">Phenytoin</a></li> <li><a href="/wiki/5%CE%B2-Dihydroprogesterone" title="5β-Dihydroprogesterone">Pregnanedione (5β-dihydroprogesterone)</a></li> <li><a href="/wiki/Reserpine" title="Reserpine">Reserpine</a></li> <li><a href="/w/index.php?title=TCPOBOP&action=edit&redlink=1" class="new" title="TCPOBOP (page does not exist)">TCPOBOP</a></li> <li><a href="/wiki/Telmisartan" title="Telmisartan">Telmisartan</a></li> <li><a href="/wiki/Tolnaftate" title="Tolnaftate">Tolnaftate</a></li> <li><a href="/wiki/Troglitazone" title="Troglitazone">Troglitazone</a></li> <li><a href="/wiki/Valproic_acid" class="mw-redirect" title="Valproic acid">Valproic acid</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=3,17%CE%B2-Estradiol&action=edit&redlink=1" class="new" title="3,17β-Estradiol (page does not exist)">3,17β-Estradiol</a></li> <li><a href="/w/index.php?title=5%CE%B1-Androstan-3%CE%B1-ol&action=edit&redlink=1" class="new" title="5α-Androstan-3α-ol (page does not exist)">3α-Androstanol</a></li> <li><a href="/wiki/5%CE%B1-Androst-16-en-3%CE%B1-ol" class="mw-redirect" title="5α-Androst-16-en-3α-ol">3α-Androstenol</a></li> <li><a href="/w/index.php?title=5%CE%B1-Androstan-3%CE%B2-ol&action=edit&redlink=1" class="new" title="5α-Androstan-3β-ol (page does not exist)">3β-Androstanol</a></li> <li><a href="/w/index.php?title=5%CE%B1-Androstan-17-ol&action=edit&redlink=1" class="new" title="5α-Androstan-17-ol (page does not exist)">17-Androstanol</a></li> <li><a href="/wiki/Allyl_isothiocyanate" title="Allyl isothiocyanate">AITC</a></li> <li><a href="/wiki/Ethinylestradiol" title="Ethinylestradiol">Ethinylestradiol</a></li> <li><a href="/wiki/Meclizine" title="Meclizine">Meclizine</a></li> <li><a href="/w/index.php?title=Nigramide_J&action=edit&redlink=1" class="new" title="Nigramide J (page does not exist)">Nigramide J</a></li> <li><a href="/wiki/Okadaic_acid" title="Okadaic acid">Okadaic acid</a></li> <li><a href="/wiki/PK-11195" class="mw-redirect" title="PK-11195">PK-11195</a></li> <li><a href="/w/index.php?title=S-07662&action=edit&redlink=1" class="new" title="S-07662 (page does not exist)">S-07662</a></li> <li><a href="/w/index.php?title=T-0901317&action=edit&redlink=1" class="new" title="T-0901317 (page does not exist)">T-0901317</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Pregnane_X_receptor" title="Pregnane X receptor"><abbr title="Pregnane X receptor">PXR</abbr></a><span class="sr-only" style="border: 0; clip: rect(0, 0, 0, 0); clip-path: polygon(0px 0px, 0px 0px, 0px 0px); height: 1px; margin: -1px; overflow: hidden; padding: 0; position: absolute; width: 1px; white-space: nowrap;">Tooltip Pregnane X receptor</span></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/17%CE%B1-Hydroxypregnenolone" title="17α-Hydroxypregnenolone">17α-Hydroxypregnenolone</a></li> <li><a href="/wiki/17%CE%B1-Hydroxyprogesterone" title="17α-Hydroxyprogesterone">17α-Hydroxyprogesterone</a></li> <li><a href="/wiki/%CE%944-Androstenedione" class="mw-redirect" title="Δ4-Androstenedione">Δ<sup>4</sup>-Androstenedione</a></li> <li><a href="/wiki/%CE%945-Androstenediol" class="mw-redirect" title="Δ5-Androstenediol">Δ<sup>5</sup>-Androstenediol</a></li> <li><a href="/wiki/%CE%945-Androstenedione" class="mw-redirect" title="Δ5-Androstenedione">Δ<sup>5</sup>-Androstenedione</a></li> <li><a href="/w/index.php?title=AA-861&action=edit&redlink=1" class="new" title="AA-861 (page does not exist)">AA-861</a></li> <li><a href="/wiki/Allopregnanediol" title="Allopregnanediol">Allopregnanediol</a></li> <li><a href="/wiki/5%CE%B1-Dihydroprogesterone" title="5α-Dihydroprogesterone">Allopregnanedione (5α-dihydroprogesterone)</a></li> <li><a href="/wiki/Allopregnanolone" title="Allopregnanolone">Allopregnanolone (brexanolone)</a></li> <li><a href="/wiki/Alpha-Lipoic_acid" class="mw-redirect" title="Alpha-Lipoic acid">Alpha-Lipoic acid</a></li> <li><a href="/wiki/Ambrisentan" title="Ambrisentan">Ambrisentan</a></li> <li><a href="/wiki/AMI-193" class="mw-redirect" title="AMI-193">AMI-193</a></li> <li><a href="/wiki/Amlodipine_besylate" class="mw-redirect" title="Amlodipine besylate">Amlodipine besylate</a></li> <li><a href="/wiki/Antimycotic" class="mw-redirect" title="Antimycotic">Antimycotics</a></li> <li><a href="/wiki/Artemisinin" title="Artemisinin">Artemisinin</a></li> <li><a href="/wiki/Aurothioglucose" title="Aurothioglucose">Aurothioglucose</a></li> <li><a href="/wiki/Bile_acid" title="Bile acid">Bile acids</a></li> <li><a href="/wiki/Bithionol" title="Bithionol">Bithionol</a></li> <li><a href="/wiki/Bosentan" title="Bosentan">Bosentan</a></li> <li><a href="/w/index.php?title=Bumecaine&action=edit&redlink=1" class="new" title="Bumecaine (page does not exist)">Bumecaine</a></li> <li><a href="/wiki/Cafestol" title="Cafestol">Cafestol</a></li> <li><a href="/wiki/Cephaloridine" title="Cephaloridine">Cephaloridine</a></li> <li><a href="/wiki/Cephradine" class="mw-redirect" title="Cephradine">Cephradine</a></li> <li><a href="/wiki/Chlorpromazine" title="Chlorpromazine">Chlorpromazine</a></li> <li><a href="/wiki/Ciglitazone" title="Ciglitazone">Ciglitazone</a></li> <li><a href="/wiki/Clindamycin" title="Clindamycin">Clindamycin</a></li> <li><a href="/wiki/Clofenvinfos" class="mw-redirect" title="Clofenvinfos">Clofenvinfos</a></li> <li><a href="/wiki/Chloroxine" title="Chloroxine">Chloroxine</a></li> <li><a href="/wiki/Clotrimazole" title="Clotrimazole">Clotrimazole</a></li> <li><a href="/wiki/Colforsin" class="mw-redirect" title="Colforsin">Colforsin</a></li> <li><a href="/wiki/Corticosterone" title="Corticosterone">Corticosterone</a></li> <li><a href="/wiki/Cyclophosphamide" title="Cyclophosphamide">Cyclophosphamide</a></li> <li><a href="/wiki/Cyproterone_acetate" title="Cyproterone acetate">Cyproterone acetate</a></li> <li><a href="/wiki/Demecolcine" title="Demecolcine">Demecolcine</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a> (<a href="/wiki/Prasterone" title="Prasterone">prasterone</a>)</li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a> (<a href="/wiki/Prasterone_sulfate" title="Prasterone sulfate">prasterone sulfate</a>)</li> <li><a href="/wiki/Dibunate_sodium" class="mw-redirect" title="Dibunate sodium">Dibunate sodium</a></li> <li><a href="/wiki/Diclazuril" title="Diclazuril">Diclazuril</a></li> <li><a href="/wiki/Dicloxacillin" title="Dicloxacillin">Dicloxacillin</a></li> <li><a href="/wiki/Dimercaprol" title="Dimercaprol">Dimercaprol</a></li> <li><a href="/w/index.php?title=Dinaline&action=edit&redlink=1" class="new" title="Dinaline (page does not exist)">Dinaline</a></li> <li><a href="/wiki/Docetaxel" title="Docetaxel">Docetaxel</a></li> <li><a href="/wiki/Docusate_calcium" class="mw-redirect" title="Docusate calcium">Docusate calcium</a></li> <li><a href="/wiki/Dodecylbenzenesulfonic_acid" class="mw-redirect" title="Dodecylbenzenesulfonic acid">Dodecylbenzenesulfonic acid</a></li> <li><a href="/wiki/Dronabinol" title="Dronabinol">Dronabinol</a></li> <li><a href="/wiki/Droxidopa" title="Droxidopa">Droxidopa</a></li> <li><a href="/wiki/Eburnamonine" class="mw-redirect" title="Eburnamonine">Eburnamonine</a></li> <li><a href="/wiki/Ecopipam" title="Ecopipam">Ecopipam</a></li> <li><a href="/wiki/Enzacamene" title="Enzacamene">Enzacamene</a></li> <li><a href="/wiki/Epothilone_B" class="mw-redirect" title="Epothilone B">Epothilone B</a></li> <li><a href="/wiki/Erythromycin" title="Erythromycin">Erythromycin</a></li> <li><a href="/wiki/Famprofazone" title="Famprofazone">Famprofazone</a></li> <li><a href="/w/index.php?title=Febantel&action=edit&redlink=1" class="new" title="Febantel (page does not exist)">Febantel</a></li> <li><a href="/wiki/Felodipine" title="Felodipine">Felodipine</a></li> <li><a href="/wiki/Fenbendazole" title="Fenbendazole">Fenbendazole</a></li> <li><a href="/wiki/Fentanyl" title="Fentanyl">Fentanyl</a></li> <li><a href="/wiki/Flucloxacillin" title="Flucloxacillin">Flucloxacillin</a></li> <li><a href="/wiki/Fluorometholone" title="Fluorometholone">Fluorometholone</a></li> <li><a href="/wiki/Griseofulvin" title="Griseofulvin">Griseofulvin</a></li> <li><a href="/wiki/Guggulsterone" title="Guggulsterone">Guggulsterone</a></li> <li><a href="/wiki/Haloprogin" title="Haloprogin">Haloprogin</a></li> <li><a href="/wiki/Hetacillin_potassium" class="mw-redirect" title="Hetacillin potassium">Hetacillin potassium</a></li> <li><a href="/wiki/Hyperforin" title="Hyperforin">Hyperforin</a></li> <li><a href="/wiki/Hypericum_perforatum" title="Hypericum perforatum"><i>Hypericum perforatum</i> (St John's wort)</a></li> <li><a href="/wiki/Indinavir_sulfate" class="mw-redirect" title="Indinavir sulfate">Indinavir sulfate</a></li> <li><a href="/wiki/Lasalocid_sodium" class="mw-redirect" title="Lasalocid sodium">Lasalocid sodium</a></li> <li><a href="/wiki/Levothyroxine" title="Levothyroxine">Levothyroxine</a></li> <li>Linolenic acid: <a href="/wiki/%CE%91-Linolenic_acid" title="Α-Linolenic acid">α-Linolenic acid</a> and <a href="/wiki/%CE%93-Linolenic_acid" title="Γ-Linolenic acid">γ-Linolenic acid</a></li> <li><a href="/w/index.php?title=LOE-908&action=edit&redlink=1" class="new" title="LOE-908 (page does not exist)">LOE-908</a></li> <li><a href="/wiki/Loratadine" title="Loratadine">Loratadine</a></li> <li><a href="/wiki/Lovastatin" title="Lovastatin">Lovastatin</a></li> <li><a href="/wiki/Meclizine" title="Meclizine">Meclizine</a></li> <li><a href="/wiki/Metacycline" title="Metacycline">Metacycline</a></li> <li><a href="/wiki/Methylprednisolone" title="Methylprednisolone">Methylprednisolone</a></li> <li><a href="/wiki/Metyrapone" title="Metyrapone">Metyrapone</a></li> <li><a href="/wiki/Mevastatin" title="Mevastatin">Mevastatin</a></li> <li><a href="/wiki/Mifepristone" title="Mifepristone">Mifepristone</a></li> <li><a href="/wiki/Nafcillin" title="Nafcillin">Nafcillin</a></li> <li><a href="/wiki/Nicardipine" title="Nicardipine">Nicardipine</a></li> <li><a href="/wiki/Nicotine" title="Nicotine">Nicotine</a></li> <li><a href="/wiki/Nifedipine" title="Nifedipine">Nifedipine</a></li> <li><a href="/wiki/Nilvadipine" title="Nilvadipine">Nilvadipine</a></li> <li><a href="/wiki/Nisoldipine" title="Nisoldipine">Nisoldipine</a></li> <li><a href="/wiki/Norelgestromin" title="Norelgestromin">Norelgestromin</a></li> <li><a href="/wiki/Omeprazole" title="Omeprazole">Omeprazole</a></li> <li><a href="/wiki/Orlistat" title="Orlistat">Orlistat</a></li> <li><a href="/wiki/Oxatomide" title="Oxatomide">Oxatomide</a></li> <li><a href="/wiki/Paclitaxel" title="Paclitaxel">Paclitaxel</a></li> <li><a href="/wiki/Phenobarbital" title="Phenobarbital">Phenobarbital</a></li> <li><a href="/wiki/Piperine" title="Piperine">Piperine</a></li> <li><a href="/wiki/Plicamycin" title="Plicamycin">Plicamycin</a></li> <li><a href="/wiki/Prednisolone" title="Prednisolone">Prednisolone</a></li> <li><a href="/wiki/Pregnanediol" title="Pregnanediol">Pregnanediol</a></li> <li><a href="/wiki/5%CE%B2-Dihydroprogesterone" title="5β-Dihydroprogesterone">Pregnanedione (5β-dihydroprogesterone)</a></li> <li><a href="/wiki/Pregnanolone" title="Pregnanolone">Pregnanolone</a></li> <li><a href="/wiki/Pregnenolone" title="Pregnenolone">Pregnenolone</a></li> <li><a href="/wiki/Pregnenolone_16%CE%B1-carbonitrile" title="Pregnenolone 16α-carbonitrile">Pregnenolone 16α-carbonitrile</a></li> <li><a href="/wiki/Proadifen" title="Proadifen">Proadifen</a></li> <li><a href="/wiki/Progesterone" title="Progesterone">Progesterone</a></li> <li><a href="/wiki/Quingestrone" title="Quingestrone">Quingestrone</a></li> <li><a href="/wiki/Reserpine" title="Reserpine">Reserpine</a></li> <li><a href="/wiki/Reverse_triiodothyronine" title="Reverse triiodothyronine">Reverse triiodothyronine</a></li> <li><a href="/wiki/Rifampicin" title="Rifampicin">Rifampicin</a></li> <li><a href="/wiki/Rifaximin" title="Rifaximin">Rifaximin</a></li> <li><a href="/wiki/Rimexolone" title="Rimexolone">Rimexolone</a></li> <li><a href="/wiki/Riodipine" title="Riodipine">Riodipine</a></li> <li><a href="/wiki/Ritonavir" title="Ritonavir">Ritonavir</a></li> <li><a href="/wiki/Simvastatin" title="Simvastatin">Simvastatin</a></li> <li><a href="/wiki/Sirolimus" title="Sirolimus">Sirolimus</a></li> <li><a href="/wiki/Spironolactone" title="Spironolactone">Spironolactone</a></li> <li><a href="/wiki/Spiroxatrine" title="Spiroxatrine">Spiroxatrine</a></li> <li><a href="/w/index.php?title=SR-12813&action=edit&redlink=1" class="new" title="SR-12813 (page does not exist)">SR-12813</a></li> <li><a href="/w/index.php?title=Suberoylanilide&action=edit&redlink=1" class="new" title="Suberoylanilide (page does not exist)">Suberoylanilide</a></li> <li><a href="/wiki/Sulfisoxazole" class="mw-redirect" title="Sulfisoxazole">Sulfisoxazole</a></li> <li><a href="/wiki/Suramin" title="Suramin">Suramin</a></li> <li><a href="/wiki/Tacrolimus" title="Tacrolimus">Tacrolimus</a></li> <li><a href="/w/index.php?title=Tenylidone&action=edit&redlink=1" class="new" title="Tenylidone (page does not exist)">Tenylidone</a></li> <li><a href="/wiki/Terconazole" title="Terconazole">Terconazole</a></li> <li><a href="/wiki/Testosterone_isocaproate" title="Testosterone isocaproate">Testosterone isocaproate</a></li> <li><a href="/wiki/Tetracycline" title="Tetracycline">Tetracycline</a></li> <li><a href="/wiki/Thiamylal_sodium" class="mw-redirect" title="Thiamylal sodium">Thiamylal sodium</a></li> <li><a href="/wiki/Thiothixene" class="mw-redirect" title="Thiothixene">Thiothixene</a></li> <li><a href="/wiki/Thonzonium_bromide" title="Thonzonium bromide">Thonzonium bromide</a></li> <li><a href="/wiki/Tianeptine" title="Tianeptine">Tianeptine</a></li> <li><a href="/wiki/Troglitazone" title="Troglitazone">Troglitazone</a></li> <li><a href="/wiki/Troleandomycin" title="Troleandomycin">Troleandomycin</a></li> <li><a href="/w/index.php?title=Tropanyl_3,5-dimethulbenzoate&action=edit&redlink=1" class="new" title="Tropanyl 3,5-dimethulbenzoate (page does not exist)">Tropanyl 3,5-dimethulbenzoate</a></li> <li><a href="/wiki/Zafirlukast" title="Zafirlukast">Zafirlukast</a></li> <li><a href="/wiki/Zeranol" title="Zeranol">Zeranol</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Ketoconazole" title="Ketoconazole">Ketoconazole</a></li> <li><a href="/wiki/Sesamin" title="Sesamin">Sesamin</a></li></ul> </div></td></tr><tr><td class="navbox-abovebelow" colspan="2"><div> <dl><dt>See also</dt> <dd><i><a href="/wiki/Template:Receptor_modulators" title="Template:Receptor modulators">Receptor/signaling modulators</a></i></dd></dl> </div></td></tr></tbody></table></div></div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output .portal-bar-header{margin:0 1em 0 0.5em;flex:0 0 auto;min-height:24px}.mw-parser-output .portal-bar-content{display:flex;flex-flow:row wrap;flex:0 1 auto;padding:0.15em 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