Zebrafish Models May Hold the Answer to Cell Dedifferentiation

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However, recent research using animal models like zebrafish has challenged this perspective. </div> </div> <div class="header-graphic flex-1"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/Zebrafish-Model-May-Hold-the-Answer-to-Cell-Dedifferentiation.jpg" class="header-graphic-image"> </div> </div> </div> </div> <div class="container-wrapper"> <div class="wide-container"> <div class="content"> <div class="content-body text-gap">  <p>Using a zebrafish model, a research team from the University of Michigan have found a loop in the body's mitochondria may enable the dedifferentiation of cells.</p>   <p>In findings recently published in PNAS, the team observed that some cells under specific conditions may ‘retreat' up the path of differentiation, allowing them to re-differentiate into different cells. </p>   <p>These findings support a growing consensus in the scientific community that cell differentiation is not necessarily irreversible, as previously thought. </p>   <p>Cunming Duan, Professor and Director of the Undergraduate Program in Neuroscience at the University of Michigan, has a laboratory dedicated to the discovery of conserved mechanisms regulating cell development and plasticity. </p>   <p>He explained in Technology Networks that cell fate and differentiation was conventionally considered to be a one-way journey. </p>   <p>“The stem cell divides and becomes a progenitor cell, which will become the future skin, neuron, liver, or muscle cell.</p>   <p>“People also thought this was true of adult tissue regeneration,” Duan continued. </p>   <p>The concept ran that if a person cut their skin or injured a muscle, a population of adult stem cells within their body would function in the same way, dividing and proliferating into progenitor cells in an irreversible process. </p>   <p>However, research from animal models such as zebrafish in more recent years has shown that this approach may be overly simplistic.</p>   <p>While stem cells can differentiate to become different cell types, findings now indicate that cells can also – under certain conditions – revert back to a precursor cell to produce different cells in a process called dedifferentiation. </p>   <h2 id="h-investigating-cell-plasticity-using-a-zebrafish-model"><strong>Investigating Cell Plasticity Using a Zebrafish Model</strong></h2>   <p>To prospect further, Duan and his team developed a zebrafish model, labelling epithelial cells which transported calcium ions with a green fluorescent protein.</p>   <p>The research team were subsequently able to induce differentiated cells to re-enter the cell cycle, allowing them to visualise the cell dividing with a focus on the function of mitochondria. </p>   <p>When mitochondria break down sugar to produce adenosine triphosphate (ATP), they also produce reactive oxygen species (ROS): highly reactive chemicals which can cause cellular damage.</p>   <p>While mitochondria are providing mitochondrial ROS, they function as signalling molecules, which can indicate a cellular stress response.</p>   <ul> <li><a href="https://oxfordglobal.com/cell/resources/wilhelm-johannsen-beans-and-the-origins-of-genotype-and-phenotype/" target="_blank" rel="noreferrer noopener">Looking at the history of gene terminology in plant seed size</a></li>   <li><a href="https://oxfordglobal.com/cell/resources/induced-pluripotent-stem-cells-to-be-manufactured-on-the-iss/" target="_blank" rel="noreferrer noopener">Induced pluripotent stem cells manufactured on the ISS</a></li>   <li><a href="https://oxfordglobal.com/cell/resources/3d-cell-cultures-from-disease-modelling-to-toxicology/" target="_blank" rel="noreferrer noopener">The huge range of applications for 3D cell cultures</a></li> </ul>   <p></p>   <p>Researchers involved with the project observed that when cell dedifferentiation and proliferation were induced in the zebrafish model, ATP production increased: mitochondrial ROS levels went up in those cells as a result.</p>   <p>Testing the loop's impact on the cell's ability to dedifferentiate, the researchers investigated knocking out the ATP production enzyme would block ROS production and inhibit dedifferentiation. </p>   <p>Researchers examined an associated mitochondrial loop in living breast cancer cells and found that the same steps took place there.</p>   <p>“Cancer cells also have this plasticity,” explained Duan, “and it's regarded as one of the major challenges concerning why we can't easily treat them.”</p>   <p>The potential applications of this approach include the possibility of future therapeutic approaches which could regenerate damaged tissue and organs, with fresh insights based on the principle of cell dedifferentiation. </p>   <p><em>Want to receive the latest industry announcements on cell manufacture and development? 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If you'd like to know more about our upcoming 3D Cell Culture conference, </em><a href="https://oxfordglobal.com/3d-cell-culture/" target="_blank" rel="noreferrer noopener"><em>visit our event website</em></a><em> to download an agenda and register your interest.</em></p>  <div class="content-body-footer"> </div> </div> <div class="content-sidebar"> <div class="related-articles"> <h3 class="center">Related Resources</h3> <div class="article"> <a href="/nextgen-biomed/resources/the-nist-awards-1-5-million-to-improve-standardisation-in-regenerative-medicine"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/The%20NIST%20Awards%20$1.5%20Million%20to%20Improve%20Standardisation%20in%20Regenerative%20Medicine.png" class="cover-graphic-image"> </div> </a><div class="content"><a href="/nextgen-biomed/resources/the-nist-awards-1-5-million-to-improve-standardisation-in-regenerative-medicine"> <h4> The NIST Awards $1.5 Million to Improve Standardisation in Regenerative Medicine </h4> <div class="abstract"> The National Institute of Standards and Technology (NIST) has given $1.5 million to two organisations to enhance regenerative medicine standards. </div> <div class="read-more"> <a href="/nextgen-biomed/resources/the-nist-awards-1-5-million-to-improve-standardisation-in-regenerative-medicine" class="read-more-link">Read More</a> </div></a> </div> </div> <div class="article"> <a href="/nextgen-biomed/resources/kyoto-university-hospital-explores-the-potential-of-treating-type-1-diabetes-using-induced-pluripotent-stem-cells"> <div class="cover-graphic"> <img src="https://oxfordglobal.com/hubfs/Website/Images/Resources/Cell%20and%20Gene/Kyoto%20University%20Hospital%20Explores%20the%20Potential%20of%20Treating%20Type%201%20Diabetes%20Using%20Induced%20Pluripotent%20Stem%20Cells.png" class="cover-graphic-image"> </div> </a><div class="content"><a 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Zebrafish Models May Hold the Answer to Cell Dedifferentiation