CINXE.COM

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href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/drosophila" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--12">Drosophila (7)<span class="element-invisible"> Apply Drosophila filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/hamster" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--13">Hamster (6)<span class="element-invisible"> Apply Hamster filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--14">Pig (3)<span class="element-invisible"> Apply Pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/rainbow-trout" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--15">rainbow trout (3)<span class="element-invisible"> Apply rainbow trout filter </span></a></li><li class="leaf"><a 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href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay" rel="nofollow" class="facetapi-checkbox facetapi-active" id="facetapi-link--22">(-) <span class="element-invisible"> Remove Fly filter </span></a></span><span class='inactive-label'>Fly (2)</span></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/trichoplax-adhaerens" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--23">Trichoplax adhaerens (2)<span class="element-invisible"> Apply Trichoplax adhaerens filter </span></a></li><li class="leaf"><a 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href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/sheep" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--28">Sheep (1)<span class="element-invisible"> Apply Sheep filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/japanese-medaka" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--29">Japanese medaka (1)<span class="element-invisible"> Apply Japanese medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/guinea-pig" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--30">Guinea pig (1)<span class="element-invisible"> Apply Guinea pig filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/canine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--31">Canine (1)<span class="element-invisible"> Apply Canine filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/salmon" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--32">Salmon (1)<span class="element-invisible"> Apply Salmon filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/honey-bee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--33">honey bee (1)<span class="element-invisible"> Apply honey bee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/chimpanzee" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--34">chimpanzee (1)<span class="element-invisible"> Apply chimpanzee filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/marmoset" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--35">Marmoset (1)<span class="element-invisible"> Apply Marmoset filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/fish" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--36">Fish (1)<span class="element-invisible"> Apply Fish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-human-probes" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--37">Mouse (Human Probes) (1)<span class="element-invisible"> Apply Mouse (Human Probes) filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/bat" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--38">Bat (1)<span class="element-invisible"> Apply Bat filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/frog" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--39">Frog (1)<span class="element-invisible"> Apply Frog filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/ferret" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--40">Ferret (1)<span class="element-invisible"> Apply Ferret filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/locust" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--41">Locust (1)<span class="element-invisible"> Apply Locust filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/salamander" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--42">Salamander (1)<span class="element-invisible"> Apply Salamander filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/mouse-0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--43">Mouse ? (1)<span class="element-invisible"> Apply Mouse ? filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/medaka%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--44">Medaka (1)<span class="element-invisible"> Apply Medaka filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/avian" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--45">Avian (1)<span class="element-invisible"> Apply Avian filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/rhesus-macaques" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--46">rhesus macaques (1)<span class="element-invisible"> Apply rhesus macaques filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/budgerigars" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--47">Budgerigars (1)<span class="element-invisible"> Apply Budgerigars filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/zebrafish%C2%A0" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--48">Zebrafish (1)<span class="element-invisible"> Apply Zebrafish filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/monocyte-derived-macrophages" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--49">Monocyte-derived macrophages (1)<span class="element-invisible"> Apply Monocyte-derived macrophages filter </span></a></li><li class="leaf"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/human-cell-cultures" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--50">Human Cell Cultures (1)<span class="element-invisible"> Apply Human Cell Cultures filter </span></a></li><li class="leaf last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/speciescommon/murine" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--51">Murine (1)<span class="element-invisible"> Apply Murine filter </span></a></li></ul></div></div></div><div id="block-facetapi-me8miflrpzemzgefduwk3xxabiv13rxf" class="block block-facetapi clearfix"><h2 class="title">Product</h2><div class="content"><div class="item-list"><ul class="facetapi-facetapi-checkbox-links facetapi-facet-im-field-product" id="facetapi-facet-apachesolrpublication-solr-server-block-im-field-product"><li class="leaf first last"><a href="/science/scientific-resources/publications/multiplex/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-multiplex-fluorescent-assay/product/rnascope%3Csup%3E%C2%AE%3C/sup%3E-ls-multiplex-assay/speciescommon/fly/product/rnascope-multiplex-fluorescent-assay" rel="nofollow" class="facetapi-checkbox facetapi-inactive" id="facetapi-link--55">RNAscope Multiplex Fluorescent Assay (2)<span class="element-invisible"> Apply RNAscope Multiplex Fluorescent Assay filter </span></a></li></ul></div></div></div></div></div></div></div><div class="col-sm-9 result"><div class="region region-content"><div id="block-system-main" class="block block-system clearfix"><div class="content"><div class="search-results apachesolr_search-results"><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name"> <a href="https://www.nature.com/articles/s41467-022-29071-4"> Clueless/CLUH regulates mitochondrial fission by promoting recruitment of Drp1 to mitochondria </a></div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2022 Mar 24</p></div><div class="clear"></div><div class="col-sm-8"><p> Yang, H;Sibilla, C;Liu, R;Yun, J;Hay, BA;Blackstone, C;Chan, DC;Harvey, RJ;Guo, M; <br/> PMID: <a href="https://www.nature.com/articles/s41467-022-29071-4" target="_blank">35332133</a> | DOI: 10.1038/s41467-022-29071-4</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Mitochondrial fission is critically important for controlling mitochondrial morphology, function, quality and transport. Drp1 is the master regulator driving mitochondrial fission, but exactly how Drp1 is regulated remains unclear. Here, we identified Drosophila Clueless and its mammalian orthologue CLUH as key regulators of Drp1. As with loss of drp1, depletion of clueless or CLUH results in mitochondrial elongation, while as with drp1 overexpression, clueless or CLUH overexpression leads to mitochondrial fragmentation. Importantly, drp1 overexpression rescues adult lethality, tissue disintegration and mitochondrial defects of clueless null mutants in Drosophila. Mechanistically, Clueless and CLUH promote recruitment of Drp1 to mitochondria from the cytosol. This involves CLUH binding to mRNAs encoding Drp1 receptors MiD49 and Mff, and regulation of their translation. Our findings identify a crucial role of Clueless and CLUH in controlling mitochondrial fission through regulation of Drp1.</div></div><div class="row row-static row-publication"><div class="col-sm-8"><div class="pro-title name">Brain-specific lipoprotein receptors interact with astrocyte derived apolipoprotein and mediate neuron-glia lipid shuttling</div></div><div class="col-sm-2"><p>Nature communications</p></div><div class="col-sm-2"><p>2021 Apr 23</p></div><div class="clear"></div><div class="col-sm-8"><p> Yin, J;Spillman, E;Cheng, ES;Short, J;Chen, Y;Lei, J;Gibbs, M;Rosenthal, JS;Sheng, C;Chen, YX;Veerasammy, K;Choetso, T;Abzalimov, R;Wang, B;Han, C;He, Y;Yuan, Q; <br/> PMID: 33893307 | DOI: 10.1038/s41467-021-22751-7</p></div><div class="clear"></div><div class="descp publication-abstract-read"> Lipid shuttling between neurons and glia contributes to the development, function, and stress responses of the nervous system. To understand how a neuron acquires its lipid supply from specific lipoproteins and their receptors, we perform combined genetic, transcriptome, and biochemical analyses in the developing Drosophila larval brain. Here we report, the astrocyte-derived secreted lipocalin Glial Lazarillo (GLaz), a homolog of human Apolipoprotein D (APOD), and its neuronal receptor, the brain-specific short isoforms of Drosophila lipophorin receptor 1 (LpR1-short), cooperatively mediate neuron-glia lipid shuttling and support dendrite morphogenesis. The isoform specificity of LpR1 defines its distribution, binding partners, and ability to support proper dendrite growth and synaptic connectivity. By demonstrating physical and functional interactions between GLaz/APOD and LpR1, we elucidate molecular pathways mediating lipid trafficking in the fly brain, and provide in vivo evidence indicating isoform-specific expression of lipoprotein receptors as a key mechanism for regulating cell-type specific lipid recruitment.</div></div></div><div id="probes-info-table" class="search-probes-info"><div class="ecom-feature-container"><div class="help-ticket-close ">X</div><div class="ecom-feature-content"><div class="probes-help-text classification"><table cellspacing="0" border="0"><colgroup span="3" width="85"></colgroup><thead><tr><th></th><th>Description</th></tr></thead><tbody><tr><td>sense<br><strong>Example:</strong> Hs-LAG3-sense</td><td>Standard probes for RNA detection are in antisense. 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action="https://proteinsimple--obtfull.my.salesforce.com/servlet/servlet.WebToCase?encoding=UTF-8" id="web-to-case1" method="POST"><div class="row"><div class="col-md-6"> <label for="fname">First Name</label> <input id="fname" maxlength="80" name="fname" size="20" type="text"></div><div class="col-md-6"> <label for="lname">Last Name</label> <input id="lname" maxlength="80" name="lname" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="email">Email</label> <input id="email" maxlength="80" name="email" size="20" type="text"></div><div class="col-md-6"> <label for="phone">Phone</label> <input id="phone" maxlength="40" name="phone" size="20" type="text"></div></div><div class="row"><div class="col-md-6"> <label for="company">Institution / Company</label> <input id="company" maxlength="80" name="company" size="20" type="text"></div></div><div class="row"><div class="col-md-12"> <label for="description">Message</label> <textarea 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576-8798</p></div><div class="row"><p> </p><div class="row"><h3>Bio-Techne</h3><p>19 Barton Lane <br />Abingdon Science Park<br />Abingdon<br />OX14 3NB<br />United Kingdom<br />Phone 2: +44 1235 529449<br />Fax: +44 1235 533420</p><p> </p></div><div class="row"><h3>Advanced Cell Diagnostics China</h3><p>20F, Tower 3,<br />Raffles City Changning Office,<br />1193 Changning Road, Shanghai 200051</p><p>021-52293200<br /><a href="mailto:info.cn@bio-techne.com">info.cn@bio-techne.com</a><br />Web: <a href="http://www.acdbio.com/cn">www.acdbio.com/cn</a></p></div><div class="row"><p>For general information: <a href="mailto:Info.ACD@bio-techne.com">Info.ACD@bio-techne.com</a><br />For place an order: <a href="mailto:order.ACD@bio-techne.com">order.ACD@bio-techne.com</a><br />For product support: <a href="mailto:support.ACD@bio-techne.com">support.ACD@bio-techne.com</a><br />For career opportunities: <a href="mailto:hr.ACD@bio-techne.com">hr.ACD@bio-techne.com</a></p></div></div><div class="row" style="border-bottom: none;"><div class="col-md-6"> <a href="/about/distributors" class="meet-out-sales-team" title="See Distributors">See Distributors</a></div></div></div></div><div class="needhelp-tab-container tab-pane fade" id="contactpharma"><div class="supportform-con"><div class="contact-tab-form supportform-con"><form id="mktoForm_9817"></form> <script>MktoForms2.loadForm("//info.bio-techne.com", "584-XSF-168", 9817);</script> </div></div></div></div></div></div></div></div></div></div> <script type="text/javascript"> jQuery(document).ready(function($) { $("#web-to-case1").validate({ // Specify the validation rules rules: { fname: "required", lname: "required", phone:"required", email: { required: true, email: true }, company: "required", case_captcha: "required" }, // Specify the validation error messages messages: { fname: "Please enter your First Name", lname: "Please enter your Last Name", email: "Please enter your email address", phone: "Please enter your 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