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How Is AMVUTTRA Given? | AMVUTTRA® (vutrisiran)
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class="container"> </div> </div> <div id="block-amvuttra-content" class="block-system-main"> <article data-history-node-id="6" role="article" about="/dosing" class="node node--basic-page-with-sections --view-mode--full"> <div class="node__content"> <div class="sections basic_page_with_sections__item"> <div class="sections__item --image"> <div class="image-mobile1"> <div class="image-mobile1__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/4.0-hero-mb-2x.png" width="750" height="392" alt="Kelly, treated with AMVUTTRA®" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/4.0-hero-img-2x.png" width="2740" height="540" alt="Kelly, treated with AMVUTTRA®" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> <div class="text"> <div class="text__item"><p>“I’d like other patients battling this disease to know that you don’t have to let it define you.”</p><span class="name">—KELLY</span>, treated with AMVUTTRA<sup>®</sup></div> </div> </div> <div class="sections__item --title"> <div class="title"> <div class="title__item">How is AMVUTTRA® given?</div> </div> </div> <div class="sections__item --large_text"> <h1 style="height:1px;overflow:hidden;">How is AMVUTTRA® given?</h1> <p>AMVUTTRA is given <strong>4 times per year</strong> as a subcutaneous injection by a healthcare professional, such as a doctor or nurse.</p> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --large_text"> <h3>Receiving AMVUTTRA</h3> <ul><li>AMVUTTRA is given as a subcutaneous injection once every 3 months</li> <li>Subcutaneous injections are given under the skin, and the process may take a few minutes</li> </ul> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --title"> <div class="title"> <div class="title__item">AMVUTTRA can be given in the following areas of the body:</div> </div> </div> <div class="blocks__item --image"> <div class="image-mobile1"> <div class="image-mobile1__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/4.0-areas-of-body-mb.png" width="591" height="353" alt="Abdomen, Thigh, Upper arm" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--full"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/4.0-areas-of-body-dt.png" width="793" height="509" alt="Abdoment, Thigh, Upper arm" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="blocks__item --callout_box"> <div class="large-text"> <div class="large-text__item"><p>With AMVUTTRA treatment, no premedications or laboratory monitoring are required.</p></div> </div> </div> <div class="blocks__item --large_text"> <p id="treatment-process" style="clip-path: polygon(0% 0%, 0% 0%, 0% 0%);height: 1px;position: absolute;bottom: -60px;">Treatment process</p> </div> </div> </div> <div class="sections__item --single_video"> <div class="title"> <div class="title__item">Watch the video to learn more about the treatment process with AMVUTTRA</div> </div> <div class="image"> <div class="image__item"> <img src="/sites/default/files/2022-10/3.0-video-w-playbutton.png" width="1540" height="866" alt="Treatment Process With AMVUTTRA video thumbnail" loading="lazy" typeof="foaf:Image" /> </div> </div> <div class="video"> <div class="video__item"> <div class="media media--video --view-mode--default"> <div class="media-video-file"> <div class="media-video-file__item"><a id="video-treatment"></a> <div class="video-item"> <video width="640" height="480" playsinline="playsinline"> <source src="/sites/default/files/2023-03/video-treatment.mp4" type="video/mp4" /> </video> <button class="inner-play-video"></button> <div class="controls"> <button class="play"></button> <div class="time"> <div class="current">00:00</div> </div> <div class="timeline"> <input type="range" name="" id="" min="0" max="100" value="0" step="0.01"> <div class="inner"></div> <div class="bar"></div> </div> <div class="volume-control"> <button class="volume"></button> <input type="range" name="" id="" min="0" max="100" value="100" step="0.05"> <div class="bar"></div> </div> <!-- <button class="options"></button> --> <button class="fullscreen"></button> </div> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --collection_of_blocks"> <div class="blocks"> <div class="blocks__item --title"> <div class="title"> <div class="title__item">Treatment site options</div> </div> </div> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --container_block"> <div class="blocks"> <div class="blocks__item --large_text"> <ul><li>You can work with your doctor to choose where you receive AMVUTTRA: your doctor’s office, a local clinic, or your own home (if eligible)</li> <li>You may be eligible to have your treatment administered at home by a healthcare professional, if covered by your insurance plan. Talk to your doctor to find out if home administration is right for you</li> </ul> </div> <div class="blocks__item --link_icon"><a class="link" href="/find-a-treatment-center" title="Find a Treatment Center" > Find a Treatment Center <div class="image-default"> <div class="image-default__item"> <div class="media media--image --view-mode--default"> <div class="media-image"> <div class="media-image__item"> <img src="/sites/default/files/2023-11/icon-find-center.svg" alt="Find a treatment center" loading="lazy" typeof="foaf:Image" /> </div> </div> </div> </div> </div> </a> </div> </div> </div> </div> </div> </div> </div> <div class="sections__item --big_blue_link"><a class="link" href="/resources" title="Learn about support and resources"> <span class="up-next">Up next</span> <span class="title text-right">Learn about support and resources</span> <span class="arrow"> <svg cache-id="18a3c6d249ce44cbb9ffbddd8d1dc4b3" id="ePvaDMrUYOV1" xmlns="http://www.w3.org/2000/svg" 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</a></div> </div> </div> </article> </div> <div id="isi" id="block-isi" class="isi-inline"> <div class="container"> <div class="body"> <div class="body__item"><h2>Important Safety Information and Indication</h2> <h3>Important Safety Information</h3> <h4>What are the most important things I should know about AMVUTTRA<sup>®</sup> (vutrisiran)?</h4> <p>AMVUTTRA can cause:</p> <ul><li> <h4>Low Vitamin A Levels</h4> <p>Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</p> <p>Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</p> </li> </ul><h4>What are the common side effects of AMVUTTRA?</h4> <p>The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</p> <p>These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</p> <h3>Indication</h3> <h4>What is AMVUTTRA?</h4> <p>AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.</p> <h4>For additional information about AMVUTTRA, please see the full <a href="https://www.alnylam.com/sites/default/files/pdfs/amvuttra-us-prescribing-information.pdf" target="_blank">Prescribing Information</a>.</h4> <div class="w-full text-center"><a class="for-hcp" href="https://www.amvuttrahcp.com">For healthcare providers</a></div></div> </div> </div> </div><div class="isi-tray collapsed"> <div class="container relative"> <button class="toggle-isi"> <img class="open" src="/themes/amvuttra/assets/images/0.0-icn-plus.svg" alt="Open ISI" /> <img class="close" src="/themes/amvuttra/assets/images/0.0-icn-x-lg.svg" alt="Close ISI" /> </button> <div class="paragraphs"> <div class="paragraphs__item --embed_block"> <div class="block"> <div class="block__item"><div id="block-isicontent" class="block-block-content:0a26fb4c-c9db-4f7e-9c83-83eee0fd1104"> <div class="body"> <div class="body__item"><div class="h1">Important Safety Information and Indication</div> <div class="h2">Important Safety Information</div> <div class="h3">What are the most important things I should know about AMVUTTRA® (vutrisiran)?</div> <div class="p">AMVUTTRA can cause:</div> <div class="ul"> <div class="li"> <div class="h3">Low Vitamin A Levels</div> <div class="p">Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.</div> <div class="p">Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.</div> </div> </div> <div class="h3">What are the common side effects of AMVUTTRA?</div> <div class="p">The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.</div> <div class="p">These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit <a href="https://www.fda.gov/medwatch">www.fda.gov/medwatch</a>, or call 1-800-FDA-1088.</div> <div class="h2">Indication</div> <div class="h3">What is AMVUTTRA?</div> <div class="p">AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). 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