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d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></a></li><li class="breadcrumb-item icon-arrow_right active"><span class="breadcrumb-text">Stem Cell Biology</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-default"><div class="frame frame-size-default frame-default frame-type-container_2columns_left frame-layout-default frame-background-none frame-no-backgroundimage frame-space-before-none frame-space-after-none departmentintro-show"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="contentcontainer" data-container-identifier="container_2_columns_left"><div class="contentcontainer-column" data-container-column="left"><div class="frame frame-size-default frame-default frame-type-textmedia frame-layout-default frame-background-none frame-no-backgroundimage frame-space-before-none frame-space-after-none"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><h2>Stem cell research for tomorrow's therapies</h2><p>The focus of the Department of Stem Cell Biology is on modeling diseases of the nervous system. In this context, patient-specific cell models are generated with the aid of human stem cells. Starting from somatic cells of patients, pluripotent stem cells are generated by transformation. Biochemical, neurophysiological and imaging approaches are used to search for disease-specific changes in the patient's own cells. The goal is to better understand disease mechanisms. This knowledge should give a boost to potential therapeutic approaches in the future.</p><p>The main research areas of Erlangen Stem Cell Biology are:</p><ul class="list-normal"><li>Modeling of sporadic and genetic motor neuron diseases (ALS, HSP).</li><li>Modeling of sporadic and genetic Parkinson's disease</li><li>Modeling of the gut-brain axis</li></ul></div></div></div></div></div></div><div class="contentcontainer-column" data-container-column="right"><div class="frame frame-size-default frame-default frame-type-textmedia frame-layout-default frame-background-none frame-no-backgroundimage frame-space-before-none frame-space-after-none"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="contactbox contactbox-light"><h3 class="flag bg-secondary">Head of Department</h3><div class="contact-image-wrap contact-image-wrap-large"><div class="contact-image"><div class="image-wrap"><figure class="image"><div class="position-relative"><picture class=""><source data-variant="default" data-width="74" data-height="74" srcset="/fileadmin/_processed_/3/3/csm_Winner_Beate_2_01_867fc60f6b.jpg 1x"><img class="img-fluid" loading="lazy" src="/fileadmin/_processed_/3/3/csm_Winner_Beate_2_01_3008eb8011.jpg" width="74" height="74" title="" alt=""></picture></div></figure></div></div><div class="contact-title"><h4 class="h6">Prof. Dr. med. Beate Winner</h4></div></div></div><div class="my-4 d-landingpage"><a href="/en/" target="_blank" title="Go to the Stem Cell Biology homepage" class="btn btn-primary"><span class="link link-external">Go to Homepage Stem Cell Biology</span></a></div></div></div></div></div></div></div></div></div></div></div></div></div><div id="c83155" class=" frame frame-default frame-type-custom_factlist frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="factlist d-grid" data-count="4"><div class="fact-item fact-item-1 text-center hover--zoom "><a href="/fileadmin/dateien/content_pool_dateien/UKER_qm-bericht.pdf" class="stretched-link"></a><div class="icon text-secondary"><img 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d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></div></div><div class="card-body"><div class="h5 card-subtitle">21.08.2018</div><h4 class="card-title"><a class="stretched-link" title="α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies" href="/en/news/news/detail/%CE%B1-synuclein-oligomers-induce-early-axonal-dysfunction-in-human-ipsc-based-models-of-synucleinopathies-1/"> α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies </a></h4></div><div class="card-footer"></div></div></div><div class="card-group-element-item"><div class="card card--zoom card--shadowed"><div class="card-img-top"><div class="default-image ratio ratio-16x9"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path d="M62.813+21.0438L41.876+21.0438L41.876+42.3789L62.813+42.3789L62.813+21.0438Z" opacity="1" fill="#00a579"/><path d="M41.876+21.0438L20.938+21.0438L20.938+42.3789L41.876+42.3789L41.876+21.0438Z" opacity="1" fill="#2761ab"/><path d="M41.876+42.3788L20.938+42.3788L20.938+63.7138L41.876+63.7138L41.876+42.3788Z" opacity="1" fill="#00B1EB"/><path d="M41.876-0.29126L20.938-0.29126L20.938+21.0451L41.876+21.0451L41.876-0.29126Z" opacity="1" fill="#00B1EB"/></g></svg></div></div><div class="card-body"><div class="h5 card-subtitle">10.07.2018</div><h4 class="card-title"><a class="stretched-link" title="Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease" href="/en/news/news/detail/th17-lymphocytes-induce-neuronal-cell-death-in-a-human-ipsc-based-model-of-parkinson-s-disease-1/"> Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson’s Disease </a></h4><p>Cell Stem Cell</p></div><div class="card-footer"></div></div></div><div class="card-group-element-item"><div class="card card--zoom card--shadowed"><div class="card-img-top"><div class="ratio ratio-16x9"><picture class=""><img class="img-fluid" loading="lazy" src="/fileadmin/einrichtungen/seltene_erkrankungen/news/TWS.jpg" width="444" height="334" title="" alt=""></picture></div></div><div class="card-body"><div class="h5 card-subtitle">17.04.2018</div><h4 class="card-title"><a class="stretched-link" title="Tom Wahlig Foundation supports two projects on stem cell based models of hereditary spastic paraplegia" href="/en/news/news/detail/tom-wahlig-foundation-supports-two-projects-on-stem-cell-based-models-of-hereditary-spastic-paraplegia-1/"> Tom Wahlig Foundation supports two projects on stem cell based models of hereditary spastic paraplegia </a></h4></div><div class="card-footer"></div></div></div></div><div class="mt-4 mt-lg-5"><a class="link link-internal h6-link" href="/en/news/"> All current news </a></div></div></div></div></div></div></div><div id="c52839" class=" frame frame-default frame-type-list frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><a id="c83162"></a></div></div></div></div></div></div><div class="section section-before-footer"><div id="c83157" class=" frame frame-default 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