RNA Imaging Probe 1c (8813) by Tocris, Part of Bio-Techne

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id="pp-page-title-brand-wrapper"> <div id="header-subheader" data-section="section-base--header-subheader"> <div class="row" id="pp-page-title-brand-wrapper"> <div class="col-lg-9 col-md-12"> <h1 class="font-weight-bold"> RNA Imaging Probe 1c </h1> <h2 class="font-weight-normal h4"> Tocris Bioscience, part of Bio-Techne <span id="product-code"> | Catalog # <span class="font-weight-bold">8813</span> </span> </h2> <div id="pp-reviews-citations-row"> <div id="header_left" class="row"> <div class="col-auto d-flex align-self-center"> <div> <a href="#product-documents" class="datasheet_link product-documents" rel="nofollow">COA / SDS</a> </div> </div> </div> </div> <div id="new_version_available"> </div> <div class="row mb-2" id="extended-description"> <div class="col-md-10 extended-description-wrapper" id="extended-description-wrapper"> Fluorogenic RNA imaging probe </div> </div> </div> <div class="col-lg-3 col-md-12"> <img src="https://resources.bio-techne.com/bio-techne-assets/images/logos/bio-techne-tocris.svg" alt="Tocris Bioscience, part of Bio-Techne" class="d-flex h-100 w-100"> </div> </div> </div> </div> <div id="product_alerts_wrapper"><article class="product-data-wrapper"> </article> </div> </div> <div class="row border-top mb-2" id="images_atc_orderinfo_wrapper"><div class="col-xl-9 mt-2" id="image_atc_keydetails_wrapper"><div class="row" id="image_atc_wrapper"><div class="col-xl-4 order-xl-first" id="image_wrapper"><article class="product-data-wrapper"> <div class="image-slider-container"> <div class="product-image-lightbox tocris-image" data-brand="tocris"> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202411579.jpg" alt="Live HeLa cells labeled with RNA Imaging Probe 1c" title="Application of RNA Imaging Probe 1c on live HeLa cells." data-caption="Confocal fluorescence images of live HeLa cells imaged with 20 μM methyl pyridinium indole (MPI) (green) ( lambda ex = 470 nm, lambda em = 525−555 nm) and 20 μM RNA Imaging Probe 1c (red) ( lambda ex = 550 nm, lambda em = 580−620 nm) for 30 min. Scale bar: 10 μm." data-badges="" data-application="Confocal Microscopy" width="250" height="250" fetchpriority=high as=image class="search_result_thumbnail_image" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> <span class="image-count-text align-middle">(5)</span> </div> </div> </div> <i data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412164.jpg" data-alt="DAPI counterstaining alongside RNA Imaging Probe 1c on HeLa cells" title="Application of RNA Imaging Probe 1c on PFA-fixed HeLa cells." data-caption="Confocal fluorescence images of PFA-fixed HeLa cells incubated with 20 μM RNA Imaging Probe 1c (red) and 1 μg/mL Hoechst 33342 (blue) for 30 min." data-badges="" data-application="Confocal Microscopy" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412756.jpg" data-alt="HeLa cells stained with RNA Imaging Probe 1c" title="Application of RNA Imaging Probe 1c on HeLa cells." data-caption="Zoomed-in confocal fluorescence image of HeLa cells stained with 20 μM RNA Imaging Probe 1c for 30 min. Image shows the sub-nucleolar components fibrillar center (FC) (indicated by the white arrowhead), dense fibrillar component (DFC), and outer granular component (GC) (indicated by the white arrows). Scale bar: 3 μm." data-badges="" data-application="Confocal Microscopy" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-fluorescence-imaging-15112024131259.jpg" data-alt="Yeast RNA and spermine labeled with RNA Imaging Probe 1c" title="Yeast RNA and spermine labeled with RNA Imaging Probe 1c." data-caption="Torula yeast RNA and spermine were incubated with RNA Imaging Probe 1c (10 μM). FLIM images show the formation of spherical coacervate droplets upon mixing the RNA and spermine. Image is enlarged by 1× (on the left) or by 8× (on the right). Scale bar: 10 μm." data-badges="" data-application="Fluorescence Imaging" data-width="250" data-height="250" class="none"></i> <i data-src="https://resources.bio-techne.com/images/products/structures/rna-imaging-probe-1c_8813.png" data-alt="Fluorogenic RNA imaging probe" title="RNA Imaging Probe 1c" data-caption="Fluorogenic RNA imaging probe" data-badges="" data-application="N/A" data-width="250" data-height="250" class="none"></i> </div> </div> </article> </div> <div class="col-xl-8" id="atc_wrapper"><article class="product-data-wrapper"> <div class="atc-container"> <div class="atc-block" data-type="ds" data-blockid="ProductCart" > <form action="/commerce/addtocart" method="post" class="add-to-cart-block" data-productcode="8813"> <input type="hidden" name="print-quote" class="print-quote-input" value=""> <div class="commerce-atc-full-header atc-header col-four row border-bottom pb-1 m-0"> <div class="commerce-atc-catnum atc-head col-4 col-md-3 font-weight-bold p-0">Catalog #</div> <div class="commerce-atc-availability atc-head col-md-4 p-0 font-weight-bold d-none d-md-block">Availability</div> <div class="commerce-atc-price atc-head col-4 col-md-3 p-0 font-weight-bold">Size / Price</div> <div class="commerce-atc-quantity atc-head col-4 col-3 col-md-2 text-right font-weight-bold p-0">Qty</div> </div> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> <div class="d-none search-product-mask"> <div id="ProductCart" class="atc-lines"> <div class="commerce-atc-ds-productline productline col-four row my-2 mx-0 text-left" data-catalog="8813/50U" data-hidden=""> <div class="commerce-atc-catnum col-3 col-md-3 pl-0 m-0">8813/50U</div> <div class="commerce-atc-availability col-md-4 pl-0 m-0 d-none d-md-block"> </div> <div class="commerce-atc-price col-4 col-md-3 pl-0 m-0"> </div> <div class="commerce-atc-quantity col-4 col-md-2 text-right px-0 m-0"> </div> </div> </div> <div class="atc-control ProductCart-control text-right"> <div class="row container d-flex justify-content-end mx-0 mb-3 p-0"> <div class="order-md-last m___button-atc mx-1"> <button type="submit" value="Add To Cart" class="atc-add-button btn a___button-atc m-1 col-xs-4 order-last btn-md-block w-100"> Add To Cart </button> </div> <div class="m___button-atc mx-1"> <a href="" class="atc-print-quote-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100">Print Quote</a> </div> <div class="m___button-atc mx-1"> <a href="/services/bulk-quotes?product_code=8813" class="atc-bulk-button btn btn-secondary m-1 col-xs-4 btn-md-block w-100" rel="nofollow">Bulk Order</a> </div> </div> </div> </div> </form> </div> </div> </article> </div> </div> <div class="row datapoint_list border-top" id="key_details_wrapper"><div class="col-xl-12 mt-2" id="key_details_col_wrapper"></div> </div> </div> <div class="col-xl-3 mt-2" id="orderinfo_guarantee_wrapper"><div id="order_information_wrapper"><div id="product_shipping_block_wrapper" data-brand="tocris" data-shipping="" data-source="ep-data" data-sub_category_id="73"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"><span class="sr-only">Loading...</span></div> </div> </div> <div id="video-tile-wrapper"><article class="product-data-wrapper"> <div class="video_tile_wrapper"> <article> <div> <lite-youtube videoid="J-YqGoL3m_c" style="background-image: url('https://resources.tocris.com/images/webinars/about-tocris-video.jpg');"> <a href="https://www.youtube.com/embed/J-YqGoL3m_c?autoplay=1" class="lty-playbtn" title="Introduction to Tocris"> <span class="lyt-visually-hidden">Introduction to Tocris</span> </a> </lite-youtube> </div> </article> </div> </article> </div> <div id="product_ads_wrapper"><article class="product-data-wrapper"> </article> </div> </div> </div> <div class="datapoint_list" id="key_details"><h3>Key Product Details</h3><table class=" table" id="key_details_table_wrapper"><tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Description: </td> <td class="product-data-value py-2 align-top w-75 text-break"> Fluorogenic RNA imaging probe </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Chemical Name: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 3-[(<em>E</em>)-2-(1-Methylpyridin-1-ium-4-yl)ethenyl]indolizine iodide </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Purity: </td> <td class="product-data-value py-2 align-top w-75 text-break"> ≥98% (HPLC) </td> </tr> <tr class="product-data"> <td class="product-data-label py-2 align-top text-md-left">Molecular Weight: </td> <td class="product-data-value py-2 align-top w-75 text-break"> 362.21 </td> </tr> </table> </div> <div id="view_technical_detail_links"><div class="text-center"> <a id="view_technical" href="#technical-data-tab-tab">View Full Technical Details for RNA Imaging Probe 1c</a> </div> </div> </div> <div class="tab-content"><div id="about-data-tab-tab"></div> <ul class="nav nav-tabs nav-fill " id="productTab" role="tablist"> <li class="nav-item"> <a class="nav-link active" id="technical-data-tab-tab" href="#technical-data-tab" data-toggle="tab" role="tab" aria-controls="region-2411584697015" aria-selected="true" >Technical Data</a> </li> <li class="nav-item"> <a class="nav-link" id="citations-tab-tab" href="#citations-tab" data-toggle="tab" role="tab" aria-controls="region-8061584697120" aria-selected="false" >Citations</a> </li> </ul> <div class="tab-content rounded-bottom border-left border-right border-bottom mb-3" id="ProductTabContent"><div class="tab-pane fade show active mx-4" id="technical-data-tab" data-tab-label="Technical Data" role="tabpanel" aria-labelledby="technical-data-tab-tab"><div class="product_details_anchors"><div class="product-pages-anchors nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"><li id="biological-activity_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor active" href="#biological-activity" id="biological-activity_li" >Biological Activity</a> </li> <li id="scientific-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#scientific-data" id="scientific-data_li" >Scientific Data</a> </li> <li id="spectra-viewer_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#spectra-viewer" id="spectra-viewer_li" >Spectra Viewer</a> </li> <li id="technical-data_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#technical-data" id="technical-data_li" >Technical Data</a> </li> <li id="solubility_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#solubility" id="solubility_li" >Solubility</a> </li> <li id="preparing-stock-solutions_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#preparing-stock-solutions" id="preparing-stock-solutions_li" >Preparing Stock Solutions</a> </li> <li id="calculators_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#calculators" id="calculators_li" >Calculators</a> </li> <li id="references_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 jump-anchor" href="#references" id="references_li" >References</a> </li> <li id="product-documents_li" class="nav-item m-0"> <a class="nav-link py-0 px-2 product-documents datasheet_static_link" href="#product-documents" id="product-documents_li" >Product Datasheets</a> </li> </div> <div id="biological-activity" class="nav-link px-0" data-anchor-label="Biological Activity"><div id="biological_activity_wrapper"><h3>Biological Activity for RNA Imaging Probe 1c</h3><div class="product-data-wrapper"> <p> RNA Imaging Probe 1c is a fluorogenic RNA imaging probe. RNA Imaging Probe 1c displays high membrane permeability, strong fluorogenic responses upon binding RNA, compatibility with fluorescence lifetime imaging microscopy (FLIM), low cytotoxicity, and excellent photostability. Excitation and emission maxima (λ) are 556 nm and 608 nm, respectively; quantum yield = 0.49; extinction coefficient = 27,500 M<sup>-1</sup>cm<sup>-1</sup>. Suitable for live cell imaging. </p> </div> </div> <div id="licensing_caveat_wrapper"><h3>Licensing Information</h3><div class="product-data-wrapper"> <p> Sold under license from the University of Southern California. </p> </div> </div> <div id="optical_data_wrapper"><h3>Optical Data for RNA Imaging Probe 1c</h3> <div class="row"> <div class="col-lg-12"> <table class="dye-table table table-striped table-condensed table-responsive"> <tbody> <tr> <th>λ<sub>abs</sub></th> <td>556 nm</td> </tr> <tr> <th>λ<sub>em</sub></th> <td>608 nm</td> </tr> <tr> <th>Extinction Coefficient (ε)</th> <td>27500 M<sup>-1</sup>cm<sup>-1</sup></td> </tr> <tr> <th>Quantum Yield (φ)</th> <td>0.49</td> </tr> <tr> <th>Cell Permeable</th> <td>Yes</td> </tr> </tbody> </table> </div> </div> </div> </div> <div id="scientific-data" class="nav-link px-0" data-anchor-label="Scientific Data"><table class="product-data-wrapper tablesaw tablesaw-stack table" id="data_image_table_wrapper"><h3>Scientific Data Examples for RNA Imaging Probe 1c</h3><article class="product-data-wrapper"> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202411579.jpg" data-srcset="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202411579.jpg" alt="Live HeLa cells labeled with RNA Imaging Probe 1c" title="Application of RNA Imaging Probe 1c on live HeLa cells." data-caption="Confocal fluorescence images of live HeLa cells imaged with 20 μM methyl pyridinium indole (MPI) (green) ( lambda ex = 470 nm, lambda em = 525−555 nm) and 20 μM RNA Imaging Probe 1c (red) ( lambda ex = 550 nm, lambda em = 580−620 nm) for 30 min. Scale bar: 10 μm." data-badges="" data-application="Confocal Microscopy" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Application of RNA Imaging Probe 1c on live HeLa cells.</strong> Confocal fluorescence images of live HeLa cells imaged with 20 μM methyl pyridinium indole (MPI) (green) ( lambda ex = 470 nm, lambda em = 525−555 nm) and 20 μM RNA Imaging Probe 1c (red) ( lambda ex = 550 nm, lambda em = 580−620 nm) for 30 min. Scale bar: 10 μm. </p> </td> </tr> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412164.jpg" data-srcset="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412164.jpg" alt="DAPI counterstaining alongside RNA Imaging Probe 1c on HeLa cells" title="Application of RNA Imaging Probe 1c on PFA-fixed HeLa cells." data-caption="Confocal fluorescence images of PFA-fixed HeLa cells incubated with 20 μM RNA Imaging Probe 1c (red) and 1 μg/mL Hoechst 33342 (blue) for 30 min." data-badges="" data-application="Confocal Microscopy" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Application of RNA Imaging Probe 1c on PFA-fixed HeLa cells.</strong> Confocal fluorescence images of PFA-fixed HeLa cells incubated with 20 μM RNA Imaging Probe 1c (red) and 1 μg/mL Hoechst 33342 (blue) for 30 min. </p> </td> </tr> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412756.jpg" data-srcset="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-confocal-microscopy-1511202412756.jpg" alt="HeLa cells stained with RNA Imaging Probe 1c" title="Application of RNA Imaging Probe 1c on HeLa cells." data-caption="Zoomed-in confocal fluorescence image of HeLa cells stained with 20 μM RNA Imaging Probe 1c for 30 min. Image shows the sub-nucleolar components fibrillar center (FC) (indicated by the white arrowhead), dense fibrillar component (DFC), and outer granular component (GC) (indicated by the white arrows). Scale bar: 3 μm." data-badges="" data-application="Confocal Microscopy" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Application of RNA Imaging Probe 1c on HeLa cells.</strong> Zoomed-in confocal fluorescence image of HeLa cells stained with 20 μM RNA Imaging Probe 1c for 30 min. Image shows the sub-nucleolar components fibrillar center (FC) (indicated by the white arrowhead), dense fibrillar component (DFC), and outer granular component (GC) (indicated by the white arrows). Scale bar: 3 μm. </p> </td> </tr> <tr class="row m___product-data-examples"> <td class="border-0"> <div class="image-slider-container"> <div class="product-image-lightbox" data-brand=""> <div class="text-center border rounded p-2 item d-flex align-items-center justify-content-center bg-white active"> <img src="data:image/png;base64,R0lGODlhAQABAAD/ACwAAAAAAQABAAACADs=" data-src="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-fluorescence-imaging-15112024131259.jpg" data-srcset="https://resources.bio-techne.com/images/products/8813_rna-imaging-probe-1c-fluorescence-imaging-15112024131259.jpg" alt="Yeast RNA and spermine labeled with RNA Imaging Probe 1c" title="Yeast RNA and spermine labeled with RNA Imaging Probe 1c." data-caption="Torula yeast RNA and spermine were incubated with RNA Imaging Probe 1c (10 μM). FLIM images show the formation of spherical coacervate droplets upon mixing the RNA and spermine. Image is enlarged by 1× (on the left) or by 8× (on the right). Scale bar: 10 μm." data-badges="" data-application="Fluorescence Imaging" width="250" height="250" class="search_result_thumbnail_image lazy" /> <div class="slider-open"> <div class="count-container text-center px-2 py-2 border-top border-left rounded-left"> <span class="icon-icon-image-camera-plus align-middle"></span> </div> </div> </div> </div> </div> </td> <td class="w-75 border-0 align-top"> <p> <strong>Yeast RNA and spermine labeled with RNA Imaging Probe 1c.</strong> Torula yeast RNA and spermine were incubated with RNA Imaging Probe 1c (10 μM). FLIM images show the formation of spherical coacervate droplets upon mixing the RNA and spermine. Image is enlarged by 1× (on the left) or by 8× (on the right). Scale bar: 10 μm. </p> </td> </tr> </article> </table> </div> <div id="spectra-viewer" class="nav-link px-0" data-anchor-label="Spectra Viewer"><div class="top_region pr-0" id="spectra_viewer_wrapper"> <div class="row"> <div class="col-xs-12 col-md-7"> <h3>Plan Your Experiments</h3> <p>Use our spectra viewer to interactively plan your experiments, assessing multiplexing options. View the excitation and emission spectra for our fluorescent dye range and other commonly used dyes.</p> <a href="/resources/spectra-viewer" class="btn btn-primary" title="Use our spectra viewer to interactively plan your experiments."> Spectra Viewer </a> <div class="visible-xs visible-sm"><br></div> </div> <div class="col-xs-12 col-md-4"> <a href='/resources/spectra-viewer' title='Use our spectra viewer to interactively plan your experiments.'> <img src="https://resources.bio-techne.com/bio-techne-assets/images/services/spectral-viewer.png" alt='Spectra Viewer'> </a> </div> </div> </div> </div> <div id="technical-data" class="nav-link px-0" data-anchor-label="Technical Data"><div id="technical_data_wrapper"><h3>Technical Data for RNA Imaging Probe 1c</h3><table class="tablesaw tablesaw-stack table-bordered table" id="technical_data_product-data-wrapper"><tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">M. Wt</td> <td class="product-data-value p-3 px-4 text-break"> 362.21 </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Formula</td> <td class="product-data-value p-3 px-4 text-break"> C<sub>16</sub>H<sub>15</sub>IN<sub>2</sub> </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Storage</td> <td class="product-data-value p-3 px-4 text-break"> Store at -20°C </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Purity</td> <td class="product-data-value p-3 px-4 text-break"> ≥98% (HPLC) </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">PubChem ID</td> <td class="product-data-value p-3 px-4 text-break"> 171378441 </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">InChi Key</td> <td class="product-data-value p-3 px-4 text-break"> ODMXTRDMWRHIDS-UHFFFAOYSA-M </td> </tr> <tr class="product-data"> <td class="product-data-label font-weight-bold p-3 align-top text-md-right w-25">Smiles</td> <td class="product-data-value p-3 px-4 text-break"> C[N+]1=CC=C(/C=C/C2=CC=C3N2C=CC=C3)C=C1.[I-] </td> </tr> </table> <p class="small">The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.</p> <p class="small">Tocris products are intended for laboratory research use only, unless stated otherwise.</p> </div> </div> <div id="solubility" class="nav-link px-0" data-anchor-label="Solubility"><div id="solubility"><h3>Solubility for RNA Imaging Probe 1c</h3> <table class="tablesaw tablesaw-stack table-bordered"> <thead> <tr> <th scope="col" data-tablesaw-priority="persist"></th> <th scope="col" data-tablesaw-priority="persist">Solvent</th> <th scope="col" data-tablesaw-priority="persist">Max Conc. mg/mL</th> <th scope="col" data-tablesaw-priority="persist">Max Conc. mM</th> </tr> </thead> <tbody> <tr> <th rowspan="2">Solubility</th> </tr> <tr> <td>DMSO</td> <td>7.24</td> <td> 20 </td> </tr> </tbody> </table> </div> </div> <div id="preparing-stock-solutions" class="nav-link px-0" data-anchor-label="Preparing Stock Solutions"><div id="stock_solutions_wrapper"><h3>Preparing Stock Solutions for RNA Imaging Probe 1c</h3> <p>The following data is based on the <span id="molecular_weight_type">product</span> molecular weight <span id="molecular_weight">362.21</span>.<p> <p>Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.</p> <form id="prepare_stock_solution_form" class="form-inline"> <input type="hidden" name="max_concentration" id="max_concentration_value" value="20"> <div class="d-flex mb-3"> <div> <p class="mt-2 mr-2">Select a batch to recalculate based on the batch molecular weight:</p> </div> <div> <select id="select_stock_solutions" class="form-control input-sm" name="batch"> <option value="362.21"></option> <option value="362.21">1</option> </select> <button class="btn btn-primary py-2" id="recalc_stock_soln_data">Recalculate</button> </div> </div> </form> <table class="tablesaw tablesaw-stack table-bordered"> <thead> <tr> <th scope="col" data-tablesaw-priority="persist">Concentration / Solvent Volume / Mass</th> <th scope="col" data-tablesaw-priority="persist">1 mg</th> <th scope="col" data-tablesaw-priority="persist">5 mg</th> <th scope="col" data-tablesaw-priority="persist">10 mg</th> </tr> </thead> <tbody> <tr> <td>0.2 mM</td> <td id="ss_0_2_1">13.80 mL</td> <td id="ss_0_2_5">69.02 mL</td> <td id="ss_0_2_10">138.04 mL</td> </tr> <tr> <td>1 mM</td> <td id="ss_1_1">2.76 mL</td> <td id="ss_1_5">13.80 mL</td> <td id="ss_1_10">27.61 mL</td> </tr> <tr> <td>2 mM</td> <td id="ss_2_1">1.38 mL</td> <td id="ss_2_5">6.90 mL</td> <td id="ss_2_10">13.80 mL</td> </tr> <tr> <td>10 mM</td> <td id="ss_10_1">0.28 mL</td> <td id="ss_10_5">1.38 mL</td> <td id="ss_10_10">2.76 mL</td> </tr> </tbody> </table> </div> </div> <div id="calculators" class="nav-link px-0" data-anchor-label="Calculators"><div class="calculator card p-3" id="molarity_calculator_wrapper"><h3>Molarity Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <p>Calculate the mass, volume, or concentration required for a solution.</p> <form id="molarity-calculator" class="calculator-wrapper"> <div class="form-inline"> <div class="calc_section"> <label>Mass</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-mass js-form-item-molarity-calculator-mass"> <input id="molarity_calculator_mass" class="calculator_input calculator_text form-control form-text" placeholder="mass" type="text" name="molarity_calculator_mass" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-mass-unit js-form-item-molarity-calculator-mass-unit"> <select id="molarity_calculator_mass_unit" class="calculator_select custom-select form-select" name="molarity_calculator_mass_unit"> <option value="-12">pg</option> <option value="-9">ng</option> <option value="-6">µg</option> <option value="-3" selected="selected">mg</option> <option value="0">g</option> <option value="3">kg</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Concentration</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-concentration js-form-item-molarity-calculator-concentration"> <input id="molarity_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-concentration-unit js-form-item-molarity-calculator-concentration-unit"> <select id="molarity_calculator_concentration_unit" class="calculator_select custom-select form-select" name="molarity_calculator_concentration_unit"> <option value="-15">fM</option> <option value="-12">pM</option> <option value="-9">nM</option> <option value="-6">µM</option> <option value="-3" selected="selected">mM</option> <option value="0">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-volume js-form-item-molarity-calculator-volume"> <input id="molarity_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-molarity-calculator-volume-unit js-form-item-molarity-calculator-volume-unit"> <select id="molarity_calculator_volume_unit" class="calculator_select custom-select form-select" name="molarity_calculator_volume_unit"> <option value="-9">nL</option> <option value="-6">µL</option> <option value="-3" selected="selected">mL</option> <option value="0">L</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>M. Wt*</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-molarity-calculator-molecular-weight js-form-item-molarity-calculator-molecular-weight"> <input id="molarity_calculator_molecular_weight" placeholder="mwt" class="calculator_input calculator_text form-control form-text" type="text" name="molarity_calculator_molecular_weight" value="362.21" size="10" maxlength="6"> </div> </div> </fieldset> <div class="calculator_operator mx-2 position-relative"> g/mol </div> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_molarity_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> <div class="calculator_disclaimer"> <p>*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).</p> </div> </form> </div> </article> </div> <div class="calculator card p-3" id="dilution_calculator_wrapper"><h3>Dilution Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <p>Calculate the dilution required to prepare a stock solution.</p> <form id="dilution-calculator" class="calculator-wrapper"> <div class="form-inline"> <div class="calc_section"> <label>Concentration 1 (C1)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-concentration js-form-item-dilution-calculator-concentration"> <input id="dilution_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-concentration-unit js-form-item-dilution-calculator-concentration-unit"> <select id="dilution_calculator_concentration_unit" class="calculator_select custom-select form-select" name="dilution_calculator_concentration_unit"> <option value="fM">fM</option> <option value="pM">pM</option> <option value="nM">nM</option> <option value="uM">µM</option> <option value="mM" selected="selected">mM</option> <option value="M">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume 1 (V1)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-volume js-form-item-dilution-calculator-volume"> <input id="dilution_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-volume-unit js-form-item-dilution-calculator-volume-unit"> <select id="dilution_calculator_volume_unit" class="calculator_select custom-select form-select" name="dilution_calculator_volume_unit"> <option value="nl">nL</option> <option value="ul">µL</option> <option value="ml" selected="selected">mL</option> <option value="l">L</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Concentration 2 (C2)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-concentration2 js-form-item-dilution-calculator-concentration2"> <input id="dilution_calculator_concentration2" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_concentration2" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-concentration2-unit js-form-item-dilution-calculator-concentration2-unit"> <select id="dilution_calculator_concentration2_unit" class="calculator_select custom-select form-select" name="dilution_calculator_concentration2_unit"> <option value="fM">fM</option> <option value="pM">pM</option> <option value="nM">nM</option> <option value="uM">µM</option> <option value="mM" selected="selected">mM</option> <option value="M">M</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_multiply calculator_operator mx-2 position-relative">x</div> <div class="calc_section"> <label>Volume 2 (V2)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-textfield form-item-dilution-calculator-volume2 js-form-item-dilution-calculator-volume2"> <input id="dilution_calculator_volume2" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="dilution_calculator_volume2" value="" size="10" maxlength="6"> </div> <div class="float-left mx-1 js-form-item mb-2 form-item js-form-type-select form-item-dilution-calculator-volume2-unit js-form-item-dilution-calculator-volume2-unit"> <select id="dilution_calculator_volume2_unit" class="calculator_select custom-select form-select" name="dilution_calculator_volume2_unit"> <option value="nl">nL</option> <option value="ul">µL</option> <option value="ml" selected="selected">mL</option> <option value="l">L</option> </select> </div> </div> </fieldset> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_dilution_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> </form> </div> </article> </div> <div class="calculator card p-3" id="reconstitution_calculator_wrapper"><h3>Reconstitution Calculator</h3><article class="product-data-wrapper"> <div class="product-calculator"> <form id="reconstitution-calculator" class="calculator-wrapper"> <p>The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.</p> <div class="form-inline"> <div class="calc_section"> <label>Volume (to add to vial)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-volume js-form-item-reconstitution-calculator-volume"> <input id="reconstitution_calculator_volume" placeholder="volume" class="calculator_input calculator_text form-control form-text" type="text" name="reconstitution_calculator_volume" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-volume-unit js-form-item-reconstitution-calculator-volume-unit"> <select id="reconstitution_calculator_volume_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_volume_unit"> <option value="ml">ml</option> <option value="ul" selected="selected">µl</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_equals calculator_operator mx-2 position-relative">=</div> <div class="calc_section"> <label>Mass (in vial)</label> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-mass js-form-item-reconstitution-calculator-mass"> <input id="reconstitution_calculator_mass" class="calculator_input calculator_text form-control form-text" placeholder="mass" type="text" name="reconstitution_calculator_mass" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-mass-unit js-form-item-reconstitution-calculator-mass-unit"> <select id="reconstitution_calculator_mass_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_mass_unit"> <option value="mg">mg</option> <option value="ug" selected="selected">ug</option> <option value="ng">ng</option> </select> </div> </div> </fieldset> </div> </div> <div class="calculator_divide_by calculator_operator mx-2 position-relative">÷</div> <div class="calc_section"> <div> <label>Desired Reconstitution Concentration</label> </div> <div class="form-row"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-textfield form-item-reconstitution-calculator-concentration js-form-item-reconstitution-calculator-concentration"> <input id="reconstitution_calculator_concentration" placeholder="conc." class="calculator_input calculator_text form-control form-text" type="text" name="reconstitution_calculator_concentration" value="" size="10" maxlength="6"> </div> <div class="mx-1 p-0 js-form-item mb-2 form-item js-form-type-select form-item-reconstitution-calculator-concentration-unit js-form-item-reconstitution-calculator-concentration-unit"> <select id="reconstitution_calculator_concentration_unit" class="calculator_select custom-select form-select" name="reconstitution_calculator_concentration_unit"> <option value="mg/ml">mg/ml</option> <option value="ug/ml" selected="selected">µg/ml</option> <option value="ng/ml">ng/ml</option> </select> </div> </div> </fieldset> </div> </div> </div> <div class="alert alert-danger calculator-error d-none" role="alert"></div> <div class="calculator_footer"> <fieldset class="js-form-item form-item js-form-wrapper form-wrapper"> <div class="fieldset-wrapper"> <input id="button_reconstitution_calculator_calculate" class="calculator_button btn btn-primary button js-form-submit form-submit" type="submit" name="op" value="Calculate"> </div> </fieldset> </div> </form> </div> </article> </div> </div> <div id="references" class="nav-link px-0" data-anchor-label="References"> <div id="references"> <h3>References for RNA Imaging Probe 1c</h3> <p>References are publications that support the biological activity of the product.</p> <ul> <li> <strong>Kim</strong> <a href="https://www.ncbi.nlm.nih.gov/pubmed/37200527" target="_blank" rel="nofollow">Development of highly fluorogenic styrene probes for visualizing RNA in live cells.</a> ACS Chem.Biol. 2023 PMID: 37200527 </li> </ul> </div> </div> <div id="product-datasheets-anchor" class="nav-link static-anchor p-0" data-anchor-label="Product Datasheets"></div> </div> </div> <div class="tab-pane fade mx-4 py-4" id="citations-tab" data-tab-label="Citations" role="tabpanel" aria-labelledby="citations-tab-tab"><div class="product_details_anchors mb-2"> <div class="nav mx-0 pt-4 pb-2 m___nav-anchors d-none d-lg-flex"> <li class="nav-item m-0"> <a class="nav-link jump-anchor active" href="#citations"> Citations </a> </li> </div> </div> <div id="citations"> <section id="citations-tab-content-placeholder" class="tab-content-placeholder" data-id="citations" data-product_code="8813"> <div class="spinner-border spinner-border-sm mt-3 ml-3" role="status"> <span class="sr-only">Loading...</span> </div> </section> </div> </div> </div> </div> <div id="product-documents"> <div id="datasheet-accordion" class="accordion border mb-4"> <div class="rounded-top bg-white"> <h3 class="m-0 p-3">Product Documents for RNA Imaging Probe 1c</h3> </div> <div class="card-header"> <a data-toggle="collapse" data-target="#collapse_one" aria-expanded="false" aria-controls="collapse_one"> <h5 class="mb-0"> COA </h5> </a> </div> <div id="collapse_one" class="collapse show " aria-labelledby="heading_one" data-parent="#datasheet-accordion"> <div class="card-body"> <div class="row"> <div class="col-12"> <h2>Certificate of Analysis</h2> <p>To download a Certificate of Analysis, please select a batch below.</p> </div> </div> <section class="row"> <div class="col-md-6"> <form class="form-inline"> <div class="form-group select_sds_batch"> <div class="select_wrapper"> <select class="form-control mr-2" name="coa" id="tocris_coa_select"> <option value="">Select Your Batch</option> <option value="8813_1_coa.pdf">1</option> </select> </div> <button class="btn btn-primary" id="tocris_coa_view_batch"> View Batch </button> </div> </form> </div> <div id="pdf-result" class="col-md-6 mt-2"> <div class="mt-3" id="coa-result"> </div> </div> </section> </div> </div> <div class="card-header"> <a class="collapsed" data-toggle="collapse" data-target="#collapse_three" aria-expanded="false" aria-controls="collapse_three" > <h5 class="mb-0"> SDS </h5> </a> </div> <div id="collapse_three" class="collapse rounded-bottom" aria-labelledby="heading_three" data-parent="#datasheet-accordion"> <div class="card-body"> <div class="row sds-row"> <div class="col text-bt-blue nowrap mt-3" id="sds-tocris-wrap"> <button id="sds_link" class="sds-link datasheet_link 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RNA Imaging Probe 1c (8813) by Tocris, Part of Bio-Techne