Search results for: A. Pullyblank

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Pullyblank</title> <meta name="description" content="Search results for: A. Pullyblank"> <meta name="keywords" content="A. Pullyblank"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none navbar-toggler ml-auto" type="button" data-toggle="collapse" data-target="#navbarMenu" aria-controls="navbarMenu" aria-expanded="false" aria-label="Toggle navigation"> <span class="navbar-toggler-icon"></span> </button> <div class="w-100"> <div class="d-none d-lg-flex flex-row-reverse"> <form method="get" action="https://waset.org/search" class="form-inline my-2 my-lg-0"> <input class="form-control mr-sm-2" type="search" placeholder="Search Conferences" value="A. 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Pullyblank"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: A. Pullyblank</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1</span> Urinary Volatile Organic Compound Testing in Fast-Track Patients with Suspected Colorectal Cancer</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Godwin%20Dennison">Godwin Dennison</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20E.%20Boulind"> C. E. Boulind</a>, <a href="https://publications.waset.org/abstracts/search?q=O.%20Gould"> O. Gould</a>, <a href="https://publications.waset.org/abstracts/search?q=B.%20de%20Lacy%20Costello"> B. de Lacy Costello</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20Allison"> J. Allison</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20White"> P. White</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Ewings"> P. Ewings</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Wicaksono"> A. Wicaksono</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20J.%20Curtis"> N. J. Curtis</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Pullyblank"> A. Pullyblank</a>, <a href="https://publications.waset.org/abstracts/search?q=D.%20Jayne"> D. Jayne</a>, <a href="https://publications.waset.org/abstracts/search?q=J.%20A.%20Covington"> J. A. Covington</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20Ratcliffe"> N. Ratcliffe</a>, <a href="https://publications.waset.org/abstracts/search?q=N.%20K.%20Francis"> N. K. Francis</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Colorectal symptoms are common but only infrequently represent serious pathology, including colorectal cancer (CRC). A large number of invasive tests are presently performed for reassurance. We investigated the feasibility of urinary volatile organic compound (VOC) testing as a potential triage tool in patients fast-tracked for assessment for possible CRC. Methods: A prospective, multi-centre, observational feasibility study was performed across three sites. Patients referred on NHS fast-track pathways for potential CRC provided a urine sample which underwent Gas Chromatography Mass Spectrometry (GC-MS), Field Asymmetric Ion Mobility Spectrometry (FAIMS) and Selected Ion Flow Tube Mass Spectrometry (SIFT-MS) analysis. Patients underwent colonoscopy and/or CT colonography and were grouped as either CRC, adenomatous polyp(s), or controls to explore the diagnostic accuracy of VOC output data supported by an artificial neural network (ANN) model. Results: 558 patients participated with 23 (4.1%) CRC diagnosed. 59% of colonoscopies and 86% of CT colonographies showed no abnormalities. Urinary VOC testing was feasible, acceptable to patients, and applicable within the clinical fast track pathway. GC-MS showed the highest clinical utility for CRC and polyp detection vs. controls (sensitivity=0.878, specificity=0.882, AUROC=0.884). Conclusion: Urinary VOC testing and analysis are feasible within NHS fast-track CRC pathways. Clinically meaningful differences between patients with cancer, polyps, or no pathology were identified therefore suggesting VOC analysis may have future utility as a triage tool. Acknowledgment: Funding: NIHR Research for Patient Benefit grant (ref: PB-PG-0416-20022). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=colorectal%20cancer" title="colorectal cancer">colorectal cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=volatile%20organic%20compound" title=" volatile organic compound"> volatile organic compound</a>, <a href="https://publications.waset.org/abstracts/search?q=gas%20chromatography%20mass%20spectrometry" title=" gas chromatography mass spectrometry"> gas chromatography mass spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=field%20asymmetric%20ion%20mobility%20spectrometry" title=" field asymmetric ion mobility spectrometry"> field asymmetric ion mobility spectrometry</a>, <a href="https://publications.waset.org/abstracts/search?q=selected%20ion%20flow%20tube%20mass%20spectrometry" title=" selected ion flow tube mass spectrometry"> selected ion flow tube mass spectrometry</a> </p> <a href="https://publications.waset.org/abstracts/152812/urinary-volatile-organic-compound-testing-in-fast-track-patients-with-suspected-colorectal-cancer" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/152812.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">91</span> </span> </div> </div> </div> </main> <footer> <div id="infolinks" class="pt-3 pb-2"> <div class="container"> <div style="background-color:#f5f5f5;" class="p-3"> <div class="row"> <div class="col-md-2"> <ul class="list-unstyled"> About <li><a href="https://waset.org/page/support">About Us</a></li> <li><a href="https://waset.org/page/support#legal-information">Legal</a></li> <li><a target="_blank" rel="nofollow" href="https://publications.waset.org/static/files/WASET-16th-foundational-anniversary.pdf">WASET celebrates its 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Search results for: A. Pullyblank