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class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Manuel Manchado</h3></div><div class="js-work-strip profile--work_container" data-work-id="13299839"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299839/Genetic_parameters_and_genotype_environment_interactions_for_skeleton_deformities_and_growth_traits_at_different_ages_on_gilthead_seabream_Sparus_aurata_L_in_four_Spanish_regions"><img alt="Research paper thumbnail of Genetic parameters and genotype-environment interactions for skeleton deformities and growth traits at different ages on gilthead seabream (Sparus aurata L.) in four Spanish regions" class="work-thumbnail" src="https://attachments.academia-assets.com/45496347/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299839/Genetic_parameters_and_genotype_environment_interactions_for_skeleton_deformities_and_growth_traits_at_different_ages_on_gilthead_seabream_Sparus_aurata_L_in_four_Spanish_regions">Genetic parameters and genotype-environment interactions for skeleton deformities and growth traits at different ages on gilthead seabream (Sparus aurata L.) in four Spanish regions</a></div><div class="wp-workCard_item"><span>Animal genetics</span><span>, 2015</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">One of the most important problems of fish aquaculture is the high incidence of fish deformities,...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">One of the most important problems of fish aquaculture is the high incidence of fish deformities, which are mainly skeletal. In this study, genetic parameters on gilthead seabream (Sparus aurata L.) for skeleton deformities at different ages (179, 269, 389, 539 and 689 days) and their correlations with growth traits were estimated, as were as their genotype × environment interactions (G × E) at harvesting age. A total of 4093 offspring from the mass spawning of three industrial broodstocks belonging to the PROGENSA(®) breeding programme were mixed and on-grown by different production systems in four Spanish regions: Canary Islands (tanks and cage), Andalusia (estuary), Catalonia (cage) and Murcia (cage). Parental assignment was inferred using the standardized SMsa1 microsatellite multiplex PCR. From three broodstocks, 139 breeders contributed to the spawn and a total of 297 full-sibling families (52 paternal and 53 maternal half-sibling families) were represented. Heritabilities at ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f8d3eced51a08fc77510902ad11c809" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496347,"asset_id":13299839,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496347/download_file?st=MTczMjgwOTMzOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299839"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299839"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299839; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299839]").text(description); $(".js-view-count[data-work-id=13299839]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299839; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299839']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299839, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f8d3eced51a08fc77510902ad11c809" } } $('.js-work-strip[data-work-id=13299839]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299839,"title":"Genetic parameters and genotype-environment interactions for skeleton deformities and growth traits at different ages on gilthead seabream (Sparus aurata L.) in four Spanish regions","translated_title":"","metadata":{"abstract":"One of the most important problems of fish aquaculture is the high incidence of fish deformities, which are mainly skeletal. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299838"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299838/Genome_wide_gene_expression_analysis_during_Solea_sp_embryo_larval_development"><img alt="Research paper thumbnail of Genome-wide gene expression analysis during Solea sp. embryo-larval development" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299838/Genome_wide_gene_expression_analysis_during_Solea_sp_embryo_larval_development">Genome-wide gene expression analysis during Solea sp. embryo-larval development</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ifremer.academia.edu/XavierCousin">Xavier Cousin</a></span></div><div class="wp-workCard_item"><span>Communications in agricultural and applied biological sciences</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299838"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299838"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299838; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299837"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299837/Differential_gene_expression_and_dependence_on_thyroid_hormones_of_two_glyceraldehyde_3_phosphate_dehydrogenases_in_the_flatfish_Senegalese_sole_Solea_senegalensis_Kaup_"><img alt="Research paper thumbnail of Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)" class="work-thumbnail" src="https://attachments.academia-assets.com/45496343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299837/Differential_gene_expression_and_dependence_on_thyroid_hormones_of_two_glyceraldehyde_3_phosphate_dehydrogenases_in_the_flatfish_Senegalese_sole_Solea_senegalensis_Kaup_">Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)</a></div><div class="wp-workCard_item"><span>Gene</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway. The application of large-scale genomics to Senegalese sole (Solea senegalensis) has facilitated the identification of two different genes referred to as GAPDH-1 and GAPDH-2. Main characteristics and sequence similarities with other fish and mammals are described. Phylogenetic analyses grouped both genes into two separate clusters with their mammalian counterparts as a sister clade. The expression profiles of both genes were studied during larval development and in juvenile tissues using a real-time PCR approach. In juvenile fish, GAPDH-1 was expressed mainly in muscle and GAPDH-2 in brain. During metamorphosis, GAPDH-2 mRNA levels did not change. In contrast, GAPDH-1 transcripts increased significantly between S1 and S2 metamorphic stages and reduced their levels thereafter. A treatment with the goitrogen thiourea indicated that GAPDH-1 expression was negatively regulated by thyroid ho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7503dfb2d2e38047ef4cce37a3fb1d2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496343,"asset_id":13299837,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496343/download_file?st=MTczMjgwOTMzOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299837"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299837"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299837; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299837]").text(description); $(".js-view-count[data-work-id=13299837]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299837; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299837']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299837, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7503dfb2d2e38047ef4cce37a3fb1d2a" } } $('.js-work-strip[data-work-id=13299837]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299837,"title":"Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)","translated_title":"","metadata":{"abstract":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway. 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To evaluate their effects on growth and immune system in Senegalese sole (Solea senegalensis) juveniles, a 2 Â 2 experimental design using two rations (1.0% and 0.25% of the total fish biomass) and two different initial stocking densities (7 and 30 kg m À2 ) was performed throughout a 60 days culture period. Soles fed 1.0% showed a higher specific growth rate (SGR) than those fed 0.25% (3.3-fold). No differences in SGR at 60 days were found between densities in spite of reduced values were detected at high density after 20 days (soles fed 0.25%) and 40 days (soles fed 1%) suggesting a compensatory growth. Physiologically, plasma cortisol levels were elevated in soles at high density (45-fold higher than at 7 kg m À2 ) whereas no differences associated to the feeding ration were observed. To assess the effects at a molecular level, the mRNA levels of genes involved in cellular stress (heat shock proteins HSP70 and HSP90), growth (insulinlike growth factors IGF-I, the spliced variants IGF-Ia and IGFI-b, and IGF-II) and innate immune system (g-type lysozyme and hepcidin (HAMP1)) were quantified. No differences in HSP90 expression were detected between densities or rations. In contrast, IGF-I, IGF-Ia and IGF-II showed reduced transcript levels in liver and HSP70 in liver and kidney at high density. Finally, g-type lysozyme and HAMP1 expression was greatly affected by both factors exhibiting an important reduction in the transcript levels at high density and low ration. Overall, our results show that S. senegalensis juveniles might exhibit satisfactory SGR at high density although the high plasma cortisol levels indicate a crowding stress that could negatively affect the expression levels of some of the genes studied.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"grobid_abstract_attachment_id":45496333},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299836/Effects_of_stocking_density_and_feed_ration_on_growth_and_gene_expression_in_the_Senegalese_sole_Solea_senegalensis_Potential_effects_on_the_immune_response","translated_internal_url":"","created_at":"2015-06-25T22:37:53.435-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589929,"work_id":13299836,"tagging_user_id":32551775,"tagged_user_id":5881822,"co_author_invite_id":490684,"email":"j***s@gmail.com","affiliation":"University of Barcelona","display_order":0,"name":"Josep Planas","title":"Effects of stocking density and feed ration on growth and gene expression in the Senegalese sole (Solea senegalensis): Potential effects on the immune 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In insects, a single lipoprotein, lipophorin, serves as a reusable shuttle for the transport of lipids between tissues. We have found that the two nonexchangeable apolipoproteins of lipophorin arise from a common precursor protein, apolipophorin II/I (apoLp-II/I). To examine the mechanisms of transport of lipids and liposoluble substances inside the central nervous system, this report provides the molecular cloning of a cDNA encoding the locust apoLp-II/I. We have recently shown that this precursor protein belongs to a superfamily of large lipid transfer proteins (Babin et al. J. Mol. Evol. 49:150 -160). We determined that, in addition to its expression in the fat body, the locust apoLp-II/I is also expressed in the brain. Part of the signal resulted from fat body tissue associated with the brain; however, apoLp-II/I was strongly expressed and the corresponding protein detected, in pigmented glial cells of the lamina underlying the locust retina and in cells or cellular processes interspersed in the basement membrane. The latter finding strongly suggests an implication of apolipophorins in the transport of retinoids and/or fatty acids to the insect retina.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"grobid_abstract_attachment_id":45496341},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299835/Molecular_characterization_and_gene_expression_of_thyrotropin_releasing_hormone_in_Senegalese_sole_Solea_senegalensis_","translated_internal_url":"","created_at":"2015-06-25T22:37:53.342-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589903,"work_id":13299835,"tagging_user_id":32551775,"tagged_user_id":16344334,"co_author_invite_id":null,"email":"d***a@gmail.com","display_order":0,"name":"Roger Iziga","title":"Molecular characterization and gene expression of thyrotropin-releasing hormone in Senegalese sole (Solea 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299834/Characterization_of_the_genomic_responses_in_early_Senegalese_sole_larvae_fed_diets_with_different_dietary_triacylglycerol_and_total_lipids_levels"><img alt="Research paper thumbnail of Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299834/Characterization_of_the_genomic_responses_in_early_Senegalese_sole_larvae_fed_diets_with_different_dietary_triacylglycerol_and_total_lipids_levels">Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels</a></div><div class="wp-workCard_item"><span>Comparative Biochemistry and Physiology Part D: Genomics and Proteomics</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. All these data suggest that early larvae were able to establish compensatory mechanisms for energy homeostasis regulating key molecules for FA and TAG biosynthesis, FA uptake and intracellular management of TAG and FA to warrant optimal growth rates.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299834]").text(description); $(".js-view-count[data-work-id=13299834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13299834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299834,"title":"Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels","translated_title":"","metadata":{"abstract":"The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. All these data suggest that early larvae were able to establish compensatory mechanisms for energy homeostasis regulating key molecules for FA and TAG biosynthesis, FA uptake and intracellular management of TAG and FA to warrant optimal growth rates.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"},"translated_abstract":"The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. 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ISO) driven by iodide oxidation" class="work-thumbnail" src="https://attachments.academia-assets.com/45496330/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299827/Uptake_of_iodide_in_the_marine_haptophyte_Isochrysis_sp_T_ISO_driven_by_iodide_oxidation">Uptake of iodide in the marine haptophyte Isochrysis sp.(T. ISO) driven by iodide oxidation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SVanBergeijk">S. Van Bergeijk</a></span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2ba64f281d4048277ff527a4b19df6b6" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496330,"asset_id":13299827,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496330/download_file?st=MTczMjgwOTMzOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299827"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299827"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299827; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299827]").text(description); $(".js-view-count[data-work-id=13299827]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299827; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299827']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299827, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2ba64f281d4048277ff527a4b19df6b6" } } $('.js-work-strip[data-work-id=13299827]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299827,"title":"Uptake of iodide in the marine haptophyte Isochrysis sp.(T. 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The simultaneous addition of both hydrogen peroxide (H 2 O 2 ) and a known iodide-oxidizing myeloperoxidase (MPO) significantly increased iodine uptake, but the addition of H 2 O 2 or MPO separately, had no effect on uptake. This confirms the observation that iodide is oxidized prior to uptake, but it puts into doubt the involvement of H 2 O 2 excretion and membrane-bound or extracellular haloperoxidase activity of T.ISO. The increase of iodide uptake by T.ISO upon Fe(III) addition suggests the nonenzymatic oxidation of iodide by Fe(III) in a redox reaction and subsequent influx of HOI. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299824"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299824/Molecular_and_functional_characterization_of_seven_Na_K_ATPase_%CE%B2_subunit_paralogs_in_Senegalese_sole_Solea_senegalensis_Kaup_1858_"><img alt="Research paper thumbnail of Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299824/Molecular_and_functional_characterization_of_seven_Na_K_ATPase_%CE%B2_subunit_paralogs_in_Senegalese_sole_Solea_senegalensis_Kaup_1858_">Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ifremer.academia.edu/XavierCousin">Xavier Cousin</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea senegalensis are described for the first time. Sequence analysis of the predicted polypeptides revealed a high degree of conservation with those of other vertebrate species and maintenance of important motifs involved in structure and function. Phylogenetic analysis clustered the seven genes into four main clades: β1 (atp1b1a and atp1b1b), β2 (atp1b2a and atp1b2b), β3 (atp1b3a and atp1b3b) and β4 (atp1b4). In juveniles, all paralogous transcripts were detected in the nine tissues examined albeit with different expression patterns. The most ubiquitous expressed gene was atp1b1a whereas atp1b1b was mainly detected in osmoregulatory organs (gill, kidney and intestine), and atp1b2a, atp1b2b, atp1b3a, atp1b3b and atp1b4 in brain. An expression analysis in three brain regions and pituitary revealed that β1-type transcripts were more abundant in pituitary than the other β paralogs with slight differences between brain regions. Quantification of mRNA abundance in gills after a salinity challenge showed an activation of atp1b1a and atp1b1b at high salinity water (60ppt) and atp1b3a and atp1b3b in response to low salinity (5ppt). Transcriptional analysis during larval development showed specific expression patterns for each paralog. Moreover, no differences in the expression profiles between larvae cultivated at 10 and 35ppt were observed except for atp1b4 with higher mRNA levels at 10 than 35ppt at 18days post hatch. Whole-mount in situ hybridization analysis revealed that atp1b1b was mainly localized in gut, pronephric tubule, gill, otic vesicle, and chordacentrum of newly hatched larvae. All these data suggest distinct roles of NKA β subunits in tissues, during development and osmoregulation with β1 subunits involved in the adaptation to hyperosmotic conditions and β3 subunits to hypoosmotic environments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299824"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299824"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299824; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299824]").text(description); $(".js-view-count[data-work-id=13299824]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299824; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299824']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299824, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13299824]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299824,"title":"Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)","translated_title":"","metadata":{"abstract":"In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea senegalensis are described for the first time. 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</script> <div class="js-work-strip profile--work_container" data-work-id="13299822"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish"><img alt="Research paper thumbnail of Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish" class="work-thumbnail" src="https://attachments.academia-assets.com/45496336/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish">Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4eed9760a58626d4cf4cbdb4e0867360" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496336,"asset_id":13299822,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299822"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299822"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299822; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4eed9760a58626d4cf4cbdb4e0867360" } } $('.js-work-strip[data-work-id=13299822]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299822,"title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish","translated_title":"","metadata":{"grobid_abstract":"Several microbial disease outbreaks in farm stocks of newly cultured sparid fish species, such as common seabream, redbanded seabream, and white seabream, were recorded from 2004 to 2006. This study describes the isolation and characterization of the potential causative agents, either bacteria or viruses, of these outbreaks. The isolated bacterial strains were characterized according to traditional taxonomical analyses and sequencing of a 16S rDNA fragment. Most bacteria were identified as Vibrio spp. and Photobacterium damselae subsp. damselae. The development of cytopathic effects (CPE) on different fish cell lines, the application of specific nested-PCR tests for infectious pancreatic necrosis virus (IPNV), viral nervous necrosis virus (VNNV) and viral hemorrhagic septicemia virus (VHSV), and subsequent sequence analyses were used for virus detection and identification. VNNV, related to the striped jack neural necrosis virus (SJNNV) genotype, and VHSV, related to the genotype Ia, were the only viruses detected. VNNV was isolated from the three fish species under study in five different outbreaks, whereas VHSV was isolated from common seabream and white seabream during two of these outbreaks. IPNV was not detected in any case. [Int Microbiol 2007; 10(3):193-199]","grobid_abstract_attachment_id":45496336},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish","translated_internal_url":"","created_at":"2015-06-25T22:37:52.098-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589950,"work_id":13299822,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490687,"email":"m***4@nyu.edu","display_order":0,"name":"Beatriz Martín-antonio","title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish"},{"id":1590024,"work_id":13299822,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":386454,"email":"g***a@genethon.fr","display_order":4194304,"name":"Esther García-rosado","title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish"}],"downloadable_attachments":[{"id":45496336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45496336/thumbnails/1.jpg","file_name":"Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk.pdf","download_url":"https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Co_occurrence_of_viral_and_bacterial_pat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45496336/Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk-libre.pdf?1462853465=\u0026response-content-disposition=attachment%3B+filename%3DCo_occurrence_of_viral_and_bacterial_pat.pdf\u0026Expires=1732812939\u0026Signature=fsyk8Wa572oLLa8FdWIb9qkeKclurwnZhVZQQ7d03Ej5and9kf6wkzyhPZcQozBrbG5oftdKkphtgNCnzxpZbDSO7ZrCPfNPB9H63Yvtfaiclqzwu4WivActv06JLDx~Y2nxQGIg4zCK7FtKIBihSGGjlNhlNAn~OvfsaRaubAqs0XdrpfkE1IjkxlqH6NdiM70y8~mLcOzPA-Xgfnk98FZo5pvGkcxELlVD6SPdnVNUBbWfGHJr440tVS-zlsnqca7VmB48rsQxMRMnBj4OgM2fUcEm0VAUZheFuzPDrBFWdATLOY90Zi0ZZ1N~PzgwQhlttj5JhK0~PJC0RRnEFw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":32551775,"first_name":"Manuel","middle_initials":null,"last_name":"Manchado","page_name":"ManuelManchado","domain_name":"juntadeandalucia","created_at":"2015-06-25T22:37:10.836-07:00","display_name":"Manuel Manchado","url":"https://juntadeandalucia.academia.edu/ManuelManchado"},"attachments":[{"id":45496336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45496336/thumbnails/1.jpg","file_name":"Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk.pdf","download_url":"https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Co_occurrence_of_viral_and_bacterial_pat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45496336/Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk-libre.pdf?1462853465=\u0026response-content-disposition=attachment%3B+filename%3DCo_occurrence_of_viral_and_bacterial_pat.pdf\u0026Expires=1732812940\u0026Signature=VvzUiQj3DdKwUNQDg7DYXs8Xs3tT0K2Q0x29wE9S8ZvggkDoKxWfNYAMZpeL-p7gcZCCjo9z5K~tw0GUdv9~YvdAQW2KC7Xr27Qcq3yZNKeA9N2ZxxmLfnDxJ58xO4AIWKm25h-mwRX6c0EjbU6nj1wRDm1JVzK-yuHecmFxoddsSYFkW~iyAMxfmwcPu7nrsB19OTXDvBO8opkLcmCGfNnTJYhJYE5w7DoTkH2fDu~0k9drtAeT-uCPe83GY01X7h7Rs~C5qeIn6sOeqoqExA2PWoP8v61DGABbOp2ilTuSZDTSgCQthh7l~pvTQGEdL33kfe4VgEiJDPSPnBubHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":13919,"name":"Fish Diseases","url":"https://www.academia.edu/Documents/in/Fish_Diseases"},{"id":23848,"name":"Aquaculture","url":"https://www.academia.edu/Documents/in/Aquaculture"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":57907,"name":"Disease Outbreaks","url":"https://www.academia.edu/Documents/in/Disease_Outbreaks"},{"id":379748,"name":"Vibrio","url":"https://www.academia.edu/Documents/in/Vibrio"},{"id":1323775,"name":"Sea Bream","url":"https://www.academia.edu/Documents/in/Sea_Bream"},{"id":2196318,"name":"Photobacterium","url":"https://www.academia.edu/Documents/in/Photobacterium"}],"urls":[]}, dispatcherData: dispatcherData }); 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This study aimed to isolate the IGF-I and IGF-II cDNAs and determine their temporal expression pattern in diVerent organs and throughout larval development in Senegal sole. The rapid ampliWcation of cDNA ends (RACE) was used to obtain both full-length IGFs sequences. A high sequence similarity with other teleosts sequences was observed. Domains B and A revealed as the most evolutionary conserved. Steady-state copy numbers of IGF-I and IGF-II were also quantiWed in diVerent Senegal sole tissues by real-time PCR. IGF-I and IGF-II expressed ubiquitously with the highest mRNA levels in liver (88 £ 10 6 molecules/ g total RNA) and gills (14.0 £ 10 6 molecules/ g total RNA) respectively. IGF-II mRNA levels were higher than IGF-I in prehatching embryos and premetamorphic larvae with a signiWcant drop before the commencement of eye migration in metamorphosis. The abundance of IGF-II transcripts correlated positively with the growth rate during larval development. The putative role of IGF-II on metamorphosis and larval growth is discussed.","grobid_abstract_attachment_id":45496345},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299821/Insulin_like_growth_factors_I_and_II_in_the_sole_Solea_senegalensis_cDNA_cloning_and_quantitation_of_gene_expression_in_tissues_and_during_larval_development","translated_internal_url":"","created_at":"2015-06-25T22:37:52.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589969,"work_id":13299821,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490688,"email":"j***e@juntadeandalucia.es","display_order":0,"name":"Jose Cañavate","title":"Insulin-like growth factors I and II in the sole Solea senegalensis: cDNA cloning and quantitation of gene expression in tissues and during larval development"},{"id":1589986,"work_id":13299821,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490689,"email":"e***t@juntadeandalucia.es","display_order":4194304,"name":"E. 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In this study, genetic parameters on gilthead seabream (Sparus aurata L.) for skeleton deformities at different ages (179, 269, 389, 539 and 689 days) and their correlations with growth traits were estimated, as were as their genotype × environment interactions (G × E) at harvesting age. A total of 4093 offspring from the mass spawning of three industrial broodstocks belonging to the PROGENSA(®) breeding programme were mixed and on-grown by different production systems in four Spanish regions: Canary Islands (tanks and cage), Andalusia (estuary), Catalonia (cage) and Murcia (cage). Parental assignment was inferred using the standardized SMsa1 microsatellite multiplex PCR. From three broodstocks, 139 breeders contributed to the spawn and a total of 297 full-sibling families (52 paternal and 53 maternal half-sibling families) were represented. Heritabilities at ...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="2f8d3eced51a08fc77510902ad11c809" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496347,"asset_id":13299839,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496347/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&st=MTczMjgwOTMzOCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299839"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299839"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299839; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299839]").text(description); $(".js-view-count[data-work-id=13299839]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299839; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299839']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299839, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "2f8d3eced51a08fc77510902ad11c809" } } $('.js-work-strip[data-work-id=13299839]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299839,"title":"Genetic parameters and genotype-environment interactions for skeleton deformities and growth traits at different ages on gilthead seabream (Sparus aurata L.) in four Spanish regions","translated_title":"","metadata":{"abstract":"One of the most important problems of fish aquaculture is the high incidence of fish deformities, which are mainly skeletal. In this study, genetic parameters on gilthead seabream (Sparus aurata L.) for skeleton deformities at different ages (179, 269, 389, 539 and 689 days) and their correlations with growth traits were estimated, as were as their genotype × environment interactions (G × E) at harvesting age. A total of 4093 offspring from the mass spawning of three industrial broodstocks belonging to the PROGENSA(®) breeding programme were mixed and on-grown by different production systems in four Spanish regions: Canary Islands (tanks and cage), Andalusia (estuary), Catalonia (cage) and Murcia (cage). Parental assignment was inferred using the standardized SMsa1 microsatellite multiplex PCR. From three broodstocks, 139 breeders contributed to the spawn and a total of 297 full-sibling families (52 paternal and 53 maternal half-sibling families) were represented. 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href="https://www.academia.edu/13299838/Genome_wide_gene_expression_analysis_during_Solea_sp_embryo_larval_development">Genome-wide gene expression analysis during Solea sp. embryo-larval development</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ifremer.academia.edu/XavierCousin">Xavier Cousin</a></span></div><div class="wp-workCard_item"><span>Communications in agricultural and applied biological sciences</span><span>, 2013</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" 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}); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299837"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299837/Differential_gene_expression_and_dependence_on_thyroid_hormones_of_two_glyceraldehyde_3_phosphate_dehydrogenases_in_the_flatfish_Senegalese_sole_Solea_senegalensis_Kaup_"><img alt="Research paper thumbnail of Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)" class="work-thumbnail" src="https://attachments.academia-assets.com/45496343/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299837/Differential_gene_expression_and_dependence_on_thyroid_hormones_of_two_glyceraldehyde_3_phosphate_dehydrogenases_in_the_flatfish_Senegalese_sole_Solea_senegalensis_Kaup_">Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)</a></div><div class="wp-workCard_item"><span>Gene</span><span>, 2007</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway. The application of large-scale genomics to Senegalese sole (Solea senegalensis) has facilitated the identification of two different genes referred to as GAPDH-1 and GAPDH-2. Main characteristics and sequence similarities with other fish and mammals are described. Phylogenetic analyses grouped both genes into two separate clusters with their mammalian counterparts as a sister clade. The expression profiles of both genes were studied during larval development and in juvenile tissues using a real-time PCR approach. In juvenile fish, GAPDH-1 was expressed mainly in muscle and GAPDH-2 in brain. During metamorphosis, GAPDH-2 mRNA levels did not change. In contrast, GAPDH-1 transcripts increased significantly between S1 and S2 metamorphic stages and reduced their levels thereafter. A treatment with the goitrogen thiourea indicated that GAPDH-1 expression was negatively regulated by thyroid ho...</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="7503dfb2d2e38047ef4cce37a3fb1d2a" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496343,"asset_id":13299837,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496343/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&st=MTczMjgwOTMzOSw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299837"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299837"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299837; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299837]").text(description); $(".js-view-count[data-work-id=13299837]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299837; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299837']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299837, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "7503dfb2d2e38047ef4cce37a3fb1d2a" } } $('.js-work-strip[data-work-id=13299837]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299837,"title":"Differential gene expression and dependence on thyroid hormones of two glyceraldehyde-3-phosphate dehydrogenases in the flatfish Senegalese sole (Solea senegalensis Kaup)","translated_title":"","metadata":{"abstract":"Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an essential enzyme of the glycolytic pathway. 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To evaluate their effects on growth and immune system in Senegalese sole (Solea senegalensis) juveniles, a 2 Â 2 experimental design using two rations (1.0% and 0.25% of the total fish biomass) and two different initial stocking densities (7 and 30 kg m À2 ) was performed throughout a 60 days culture period. Soles fed 1.0% showed a higher specific growth rate (SGR) than those fed 0.25% (3.3-fold). No differences in SGR at 60 days were found between densities in spite of reduced values were detected at high density after 20 days (soles fed 0.25%) and 40 days (soles fed 1%) suggesting a compensatory growth. Physiologically, plasma cortisol levels were elevated in soles at high density (45-fold higher than at 7 kg m À2 ) whereas no differences associated to the feeding ration were observed. To assess the effects at a molecular level, the mRNA levels of genes involved in cellular stress (heat shock proteins HSP70 and HSP90), growth (insulinlike growth factors IGF-I, the spliced variants IGF-Ia and IGFI-b, and IGF-II) and innate immune system (g-type lysozyme and hepcidin (HAMP1)) were quantified. No differences in HSP90 expression were detected between densities or rations. In contrast, IGF-I, IGF-Ia and IGF-II showed reduced transcript levels in liver and HSP70 in liver and kidney at high density. Finally, g-type lysozyme and HAMP1 expression was greatly affected by both factors exhibiting an important reduction in the transcript levels at high density and low ration. Overall, our results show that S. senegalensis juveniles might exhibit satisfactory SGR at high density although the high plasma cortisol levels indicate a crowding stress that could negatively affect the expression levels of some of the genes 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In insects, a single lipoprotein, lipophorin, serves as a reusable shuttle for the transport of lipids between tissues. We have found that the two nonexchangeable apolipoproteins of lipophorin arise from a common precursor protein, apolipophorin II/I (apoLp-II/I). To examine the mechanisms of transport of lipids and liposoluble substances inside the central nervous system, this report provides the molecular cloning of a cDNA encoding the locust apoLp-II/I. We have recently shown that this precursor protein belongs to a superfamily of large lipid transfer proteins (Babin et al. J. Mol. Evol. 49:150 -160). We determined that, in addition to its expression in the fat body, the locust apoLp-II/I is also expressed in the brain. Part of the signal resulted from fat body tissue associated with the brain; however, apoLp-II/I was strongly expressed and the corresponding protein detected, in pigmented glial cells of the lamina underlying the locust retina and in cells or cellular processes interspersed in the basement membrane. The latter finding strongly suggests an implication of apolipophorins in the transport of retinoids and/or fatty acids to the insect retina.","publication_date":{"day":null,"month":null,"year":2010,"errors":{}},"grobid_abstract_attachment_id":45496341},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299835/Molecular_characterization_and_gene_expression_of_thyrotropin_releasing_hormone_in_Senegalese_sole_Solea_senegalensis_","translated_internal_url":"","created_at":"2015-06-25T22:37:53.342-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589903,"work_id":13299835,"tagging_user_id":32551775,"tagged_user_id":16344334,"co_author_invite_id":null,"email":"d***a@gmail.com","display_order":0,"name":"Roger Iziga","title":"Molecular characterization and gene expression of thyrotropin-releasing hormone in Senegalese sole (Solea 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299834"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299834/Characterization_of_the_genomic_responses_in_early_Senegalese_sole_larvae_fed_diets_with_different_dietary_triacylglycerol_and_total_lipids_levels"><img alt="Research paper thumbnail of Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299834/Characterization_of_the_genomic_responses_in_early_Senegalese_sole_larvae_fed_diets_with_different_dietary_triacylglycerol_and_total_lipids_levels">Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels</a></div><div class="wp-workCard_item"><span>Comparative Biochemistry and Physiology Part D: Genomics and Proteomics</span><span>, 2014</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. All these data suggest that early larvae were able to establish compensatory mechanisms for energy homeostasis regulating key molecules for FA and TAG biosynthesis, FA uptake and intracellular management of TAG and FA to warrant optimal growth rates.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299834"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299834"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299834; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299834]").text(description); $(".js-view-count[data-work-id=13299834]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299834; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299834']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299834, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13299834]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299834,"title":"Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels","translated_title":"","metadata":{"abstract":"The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. All these data suggest that early larvae were able to establish compensatory mechanisms for energy homeostasis regulating key molecules for FA and TAG biosynthesis, FA uptake and intracellular management of TAG and FA to warrant optimal growth rates.","publication_date":{"day":null,"month":null,"year":2014,"errors":{}},"publication_name":"Comparative Biochemistry and Physiology Part D: Genomics and Proteomics"},"translated_abstract":"The aim of this work was to evaluate the genomic responses of premetamorphic sole larvae (9 days post-hatching, dph) fed diets with different lipid and triacylglycerol (TAG) content. For this purpose, two diets with high (rotifers enriched with a fish oil-based emulsion; referred to as HTAG) and low (rotifers enriched with a krill oil-based emulsion; LTAG) levels of total lipids and TAG were evaluated. Lipid class and fatty acid (FA) profiles, histological characterization of intestine, liver and pancreas and expression patterns using RNA-seq were determined. Discriminant analysis results showed that larvae could be clearly differentiated on the basis of their FA profile as a function of the diet supplied until 9dph although no difference in growth was observed. RNA-seq analysis showed that larvae fed HTAG activated coordinately the transcription of apolipoproteins (apob, apoa4, apoc2, apoe, and apobec2) and other related transcripts involved in chylomicron formation, likely to facilitate proper lipid absorption and delivery. In contrast, larvae fed LTAG showed higher mRNA levels of several pancreatic enzymes (try1a, try2, cela1, cela3, cela4, chym1, chym2, amy2a and pnlip) and appetite modulators (agrp1) and some intra- and extracellular lipases. Moreover, KEGG analysis also showed that several transcripts related to lipid metabolism and glycolysis were differentially expressed with a higher abundance in larvae fed LTAG diet. 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ISO) driven by iodide oxidation" class="work-thumbnail" src="https://attachments.academia-assets.com/45496330/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299827/Uptake_of_iodide_in_the_marine_haptophyte_Isochrysis_sp_T_ISO_driven_by_iodide_oxidation">Uptake of iodide in the marine haptophyte Isochrysis sp.(T. ISO) driven by iodide oxidation</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://independent.academia.edu/SVanBergeijk">S. 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The simultaneous addition of both hydrogen peroxide (H 2 O 2 ) and a known iodide-oxidizing myeloperoxidase (MPO) significantly increased iodine uptake, but the addition of H 2 O 2 or MPO separately, had no effect on uptake. This confirms the observation that iodide is oxidized prior to uptake, but it puts into doubt the involvement of H 2 O 2 excretion and membrane-bound or extracellular haloperoxidase activity of T.ISO. The increase of iodide uptake by T.ISO upon Fe(III) addition suggests the nonenzymatic oxidation of iodide by Fe(III) in a redox reaction and subsequent influx of HOI. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="13299824"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299824/Molecular_and_functional_characterization_of_seven_Na_K_ATPase_%CE%B2_subunit_paralogs_in_Senegalese_sole_Solea_senegalensis_Kaup_1858_"><img alt="Research paper thumbnail of Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299824/Molecular_and_functional_characterization_of_seven_Na_K_ATPase_%CE%B2_subunit_paralogs_in_Senegalese_sole_Solea_senegalensis_Kaup_1858_">Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)</a></div><div class="wp-workCard_item wp-workCard--coauthors"><span>by </span><span><a class="" data-click-track="profile-work-strip-authors" href="https://juntadeandalucia.academia.edu/ManuelManchado">Manuel Manchado</a> and <a class="" data-click-track="profile-work-strip-authors" href="https://ifremer.academia.edu/XavierCousin">Xavier Cousin</a></span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea senegalensis are described for the first time. Sequence analysis of the predicted polypeptides revealed a high degree of conservation with those of other vertebrate species and maintenance of important motifs involved in structure and function. Phylogenetic analysis clustered the seven genes into four main clades: β1 (atp1b1a and atp1b1b), β2 (atp1b2a and atp1b2b), β3 (atp1b3a and atp1b3b) and β4 (atp1b4). In juveniles, all paralogous transcripts were detected in the nine tissues examined albeit with different expression patterns. The most ubiquitous expressed gene was atp1b1a whereas atp1b1b was mainly detected in osmoregulatory organs (gill, kidney and intestine), and atp1b2a, atp1b2b, atp1b3a, atp1b3b and atp1b4 in brain. An expression analysis in three brain regions and pituitary revealed that β1-type transcripts were more abundant in pituitary than the other β paralogs with slight differences between brain regions. Quantification of mRNA abundance in gills after a salinity challenge showed an activation of atp1b1a and atp1b1b at high salinity water (60ppt) and atp1b3a and atp1b3b in response to low salinity (5ppt). Transcriptional analysis during larval development showed specific expression patterns for each paralog. Moreover, no differences in the expression profiles between larvae cultivated at 10 and 35ppt were observed except for atp1b4 with higher mRNA levels at 10 than 35ppt at 18days post hatch. Whole-mount in situ hybridization analysis revealed that atp1b1b was mainly localized in gut, pronephric tubule, gill, otic vesicle, and chordacentrum of newly hatched larvae. All these data suggest distinct roles of NKA β subunits in tissues, during development and osmoregulation with β1 subunits involved in the adaptation to hyperosmotic conditions and β3 subunits to hypoosmotic environments.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299824"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299824"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299824; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=13299824]").text(description); $(".js-view-count[data-work-id=13299824]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 13299824; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='13299824']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 13299824, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=13299824]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299824,"title":"Molecular and functional characterization of seven Na+/K+-ATPase β subunit paralogs in Senegalese sole (Solea senegalensis Kaup, 1858)","translated_title":"","metadata":{"abstract":"In the present work, seven genes encoding Na(+),K(+)-ATPase (NKA) β-subunits in the teleost Solea senegalensis are described for the first time. 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</script> <div class="js-work-strip profile--work_container" data-work-id="13299822"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish"><img alt="Research paper thumbnail of Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish" class="work-thumbnail" src="https://attachments.academia-assets.com/45496336/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish">Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish</a></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="4eed9760a58626d4cf4cbdb4e0867360" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":45496336,"asset_id":13299822,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="13299822"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="13299822"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 13299822; 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dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "4eed9760a58626d4cf4cbdb4e0867360" } } $('.js-work-strip[data-work-id=13299822]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":13299822,"title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish","translated_title":"","metadata":{"grobid_abstract":"Several microbial disease outbreaks in farm stocks of newly cultured sparid fish species, such as common seabream, redbanded seabream, and white seabream, were recorded from 2004 to 2006. This study describes the isolation and characterization of the potential causative agents, either bacteria or viruses, of these outbreaks. The isolated bacterial strains were characterized according to traditional taxonomical analyses and sequencing of a 16S rDNA fragment. Most bacteria were identified as Vibrio spp. and Photobacterium damselae subsp. damselae. The development of cytopathic effects (CPE) on different fish cell lines, the application of specific nested-PCR tests for infectious pancreatic necrosis virus (IPNV), viral nervous necrosis virus (VNNV) and viral hemorrhagic septicemia virus (VHSV), and subsequent sequence analyses were used for virus detection and identification. VNNV, related to the striped jack neural necrosis virus (SJNNV) genotype, and VHSV, related to the genotype Ia, were the only viruses detected. VNNV was isolated from the three fish species under study in five different outbreaks, whereas VHSV was isolated from common seabream and white seabream during two of these outbreaks. IPNV was not detected in any case. [Int Microbiol 2007; 10(3):193-199]","grobid_abstract_attachment_id":45496336},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299822/Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish","translated_internal_url":"","created_at":"2015-06-25T22:37:52.098-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589950,"work_id":13299822,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490687,"email":"m***4@nyu.edu","display_order":0,"name":"Beatriz Martín-antonio","title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish"},{"id":1590024,"work_id":13299822,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":386454,"email":"g***a@genethon.fr","display_order":4194304,"name":"Esther García-rosado","title":"Co-occurrence of viral and bacterial pathogens in disease outbreaks affecting newly cultured sparid fish"}],"downloadable_attachments":[{"id":45496336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45496336/thumbnails/1.jpg","file_name":"Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk.pdf","download_url":"https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Co_occurrence_of_viral_and_bacterial_pat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45496336/Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk-libre.pdf?1462853465=\u0026response-content-disposition=attachment%3B+filename%3DCo_occurrence_of_viral_and_bacterial_pat.pdf\u0026Expires=1732812939\u0026Signature=fsyk8Wa572oLLa8FdWIb9qkeKclurwnZhVZQQ7d03Ej5and9kf6wkzyhPZcQozBrbG5oftdKkphtgNCnzxpZbDSO7ZrCPfNPB9H63Yvtfaiclqzwu4WivActv06JLDx~Y2nxQGIg4zCK7FtKIBihSGGjlNhlNAn~OvfsaRaubAqs0XdrpfkE1IjkxlqH6NdiM70y8~mLcOzPA-Xgfnk98FZo5pvGkcxELlVD6SPdnVNUBbWfGHJr440tVS-zlsnqca7VmB48rsQxMRMnBj4OgM2fUcEm0VAUZheFuzPDrBFWdATLOY90Zi0ZZ1N~PzgwQhlttj5JhK0~PJC0RRnEFw__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"slug":"Co_occurrence_of_viral_and_bacterial_pathogens_in_disease_outbreaks_affecting_newly_cultured_sparid_fish","translated_slug":"","page_count":7,"language":"en","content_type":"Work","owner":{"id":32551775,"first_name":"Manuel","middle_initials":null,"last_name":"Manchado","page_name":"ManuelManchado","domain_name":"juntadeandalucia","created_at":"2015-06-25T22:37:10.836-07:00","display_name":"Manuel Manchado","url":"https://juntadeandalucia.academia.edu/ManuelManchado"},"attachments":[{"id":45496336,"title":"","file_type":"pdf","scribd_thumbnail_url":"https://attachments.academia-assets.com/45496336/thumbnails/1.jpg","file_name":"Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk.pdf","download_url":"https://www.academia.edu/attachments/45496336/download_file?st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&st=MTczMjgwOTM0MCw4LjIyMi4yMDguMTQ2&","bulk_download_file_name":"Co_occurrence_of_viral_and_bacterial_pat.pdf","bulk_download_url":"https://d1wqtxts1xzle7.cloudfront.net/45496336/Co-occurrence_of_viral_and_bacterial_pat20160509-15340-yemafk-libre.pdf?1462853465=\u0026response-content-disposition=attachment%3B+filename%3DCo_occurrence_of_viral_and_bacterial_pat.pdf\u0026Expires=1732812940\u0026Signature=VvzUiQj3DdKwUNQDg7DYXs8Xs3tT0K2Q0x29wE9S8ZvggkDoKxWfNYAMZpeL-p7gcZCCjo9z5K~tw0GUdv9~YvdAQW2KC7Xr27Qcq3yZNKeA9N2ZxxmLfnDxJ58xO4AIWKm25h-mwRX6c0EjbU6nj1wRDm1JVzK-yuHecmFxoddsSYFkW~iyAMxfmwcPu7nrsB19OTXDvBO8opkLcmCGfNnTJYhJYE5w7DoTkH2fDu~0k9drtAeT-uCPe83GY01X7h7Rs~C5qeIn6sOeqoqExA2PWoP8v61DGABbOp2ilTuSZDTSgCQthh7l~pvTQGEdL33kfe4VgEiJDPSPnBubHQ__\u0026Key-Pair-Id=APKAJLOHF5GGSLRBV4ZA"}],"research_interests":[{"id":159,"name":"Microbiology","url":"https://www.academia.edu/Documents/in/Microbiology"},{"id":6947,"name":"Medical Microbiology","url":"https://www.academia.edu/Documents/in/Medical_Microbiology"},{"id":13919,"name":"Fish Diseases","url":"https://www.academia.edu/Documents/in/Fish_Diseases"},{"id":23848,"name":"Aquaculture","url":"https://www.academia.edu/Documents/in/Aquaculture"},{"id":57808,"name":"Cell line","url":"https://www.academia.edu/Documents/in/Cell_line"},{"id":57907,"name":"Disease Outbreaks","url":"https://www.academia.edu/Documents/in/Disease_Outbreaks"},{"id":379748,"name":"Vibrio","url":"https://www.academia.edu/Documents/in/Vibrio"},{"id":1323775,"name":"Sea Bream","url":"https://www.academia.edu/Documents/in/Sea_Bream"},{"id":2196318,"name":"Photobacterium","url":"https://www.academia.edu/Documents/in/Photobacterium"}],"urls":[]}, dispatcherData: dispatcherData }); 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This study aimed to isolate the IGF-I and IGF-II cDNAs and determine their temporal expression pattern in diVerent organs and throughout larval development in Senegal sole. The rapid ampliWcation of cDNA ends (RACE) was used to obtain both full-length IGFs sequences. A high sequence similarity with other teleosts sequences was observed. Domains B and A revealed as the most evolutionary conserved. Steady-state copy numbers of IGF-I and IGF-II were also quantiWed in diVerent Senegal sole tissues by real-time PCR. IGF-I and IGF-II expressed ubiquitously with the highest mRNA levels in liver (88 £ 10 6 molecules/ g total RNA) and gills (14.0 £ 10 6 molecules/ g total RNA) respectively. IGF-II mRNA levels were higher than IGF-I in prehatching embryos and premetamorphic larvae with a signiWcant drop before the commencement of eye migration in metamorphosis. The abundance of IGF-II transcripts correlated positively with the growth rate during larval development. The putative role of IGF-II on metamorphosis and larval growth is discussed.","grobid_abstract_attachment_id":45496345},"translated_abstract":null,"internal_url":"https://www.academia.edu/13299821/Insulin_like_growth_factors_I_and_II_in_the_sole_Solea_senegalensis_cDNA_cloning_and_quantitation_of_gene_expression_in_tissues_and_during_larval_development","translated_internal_url":"","created_at":"2015-06-25T22:37:52.010-07:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":32551775,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[{"id":1589969,"work_id":13299821,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490688,"email":"j***e@juntadeandalucia.es","display_order":0,"name":"Jose Cañavate","title":"Insulin-like growth factors I and II in the sole Solea senegalensis: cDNA cloning and quantitation of gene expression in tissues and during larval development"},{"id":1589986,"work_id":13299821,"tagging_user_id":32551775,"tagged_user_id":null,"co_author_invite_id":490689,"email":"e***t@juntadeandalucia.es","display_order":4194304,"name":"E. 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