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kinetics</title> <meta name="description" content="Search results for: release kinetics"> <meta name="keywords" content="release kinetics"> <meta name="viewport" content="width=device-width, initial-scale=1, minimum-scale=1, maximum-scale=1, user-scalable=no"> <meta charset="utf-8"> <link href="https://cdn.waset.org/favicon.ico" type="image/x-icon" rel="shortcut icon"> <link href="https://cdn.waset.org/static/plugins/bootstrap-4.2.1/css/bootstrap.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/plugins/fontawesome/css/all.min.css" rel="stylesheet"> <link href="https://cdn.waset.org/static/css/site.css?v=150220211555" rel="stylesheet"> </head> <body> <header> <div class="container"> <nav class="navbar navbar-expand-lg navbar-light"> <a class="navbar-brand" href="https://waset.org"> <img src="https://cdn.waset.org/static/images/wasetc.png" alt="Open Science Research Excellence" title="Open Science Research Excellence" /> </a> <button class="d-block d-lg-none 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action="https://publications.waset.org/abstracts/search"> <div id="custom-search-input"> <div class="input-group"> <i class="fas fa-search"></i> <input type="text" class="search-query" name="q" placeholder="Author, Title, Abstract, Keywords" value="release kinetics"> <input type="submit" class="btn_search" value="Search"> </div> </div> </form> </div> </div> <div class="row mt-3"> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Commenced</strong> in January 2007</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Frequency:</strong> Monthly</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Edition:</strong> International</div> </div> </div> <div class="col-sm-3"> <div class="card"> <div class="card-body"><strong>Paper Count:</strong> 1834</div> </div> </div> </div> <h1 class="mt-3 mb-3 text-center" style="font-size:1.6rem;">Search results for: release kinetics</h1> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1834</span> Formulation and in vitro Evaluation of Sustained Release Matrix Tablets of Levetiracetam for Better Epileptic Treatment</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nagasamy%20Venkatesh%20Dhandapani">Nagasamy Venkatesh Dhandapani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility between the drug and excipients. The study revealed that there was no chemical interaction between drug and excipients used in the study. The tablets were characterized by physical and chemical parameters and results were found in acceptable limits.<em> In vitro</em> release study was carried out for the tablets using 0.1 N HCl for 2 hours and in phosphate buffer pH 7.4 for remaining time up to 12 hours. The effect of polymer concentration was studied. Different dissolution models were applied to drug release data in order to evaluate release mechanisms and kinetics. The drug release data fit well to zero order kinetics. Drug release mechanism was found as a complex mixture of diffusion, swelling and erosion. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=levetiracetam" title="levetiracetam">levetiracetam</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained-release" title=" sustained-release"> sustained-release</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrophilic%20matrix%20tablet" title=" hydrophilic matrix tablet"> hydrophilic matrix tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=HPMC%20grade%20K%20100%20MCR" title=" HPMC grade K 100 MCR"> HPMC grade K 100 MCR</a>, <a href="https://publications.waset.org/abstracts/search?q=wet%20granulation" title=" wet granulation"> wet granulation</a>, <a href="https://publications.waset.org/abstracts/search?q=zero%20order%20release%20kinetics" title=" zero order release kinetics"> zero order release kinetics</a> </p> <a href="https://publications.waset.org/abstracts/58363/formulation-and-in-vitro-evaluation-of-sustained-release-matrix-tablets-of-levetiracetam-for-better-epileptic-treatment" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58363.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1833</span> Numerical Investigation of Thermally Triggered Release Kinetics of Double Emulsion for Drug Delivery Using Phase Change Material</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Yong%20Ren">Yong Ren</a>, <a href="https://publications.waset.org/abstracts/search?q=Yaping%20Zhang"> Yaping Zhang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A numerical model has been developed to investigate the thermally triggered release kinetics for drug delivery using phase change material as shell of microcapsules. Biocompatible material n-Eicosane is used as demonstration. PCM shell of microcapsule will remain in solid form after the drug is taken, so the drug will be encapsulated by the shell, and will not be released until the target body part of lesion is exposed to external heat source, which will thermally trigger the release kinetics, leading to solid-to-liquid phase change. The findings can lead to better understanding on the key effects influencing the phase change process for drug delivery applications. The facile approach to release drug from core/shell structure of microcapsule can be well integrated with organic solvent free fabrication of microcapsules, using double emulsion as template in microfluidic aqueous two phase system. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=phase%20change%20material" title="phase change material">phase change material</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release%20kinetics" title=" drug release kinetics"> drug release kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=double%20emulsion" title=" double emulsion"> double emulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=microfluidics" title=" microfluidics"> microfluidics</a> </p> <a href="https://publications.waset.org/abstracts/22132/numerical-investigation-of-thermally-triggered-release-kinetics-of-double-emulsion-for-drug-delivery-using-phase-change-material" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/22132.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">357</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1832</span> Effect of Ethyl Cellulose and Hydroxy Propyl Methyl Cellulose Polymer on the Release Profile of Diltiazem Hydrochloride Sustained Release Pellets </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Shahana%20Sharmin">Shahana Sharmin</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In the present study, the effect of cellulose polymers Ethyl Cellulose and Hydroxy Propyl Methyl Cellulose was evaluated on the release profile of drug from sustained release pellet. Diltiazem Hydrochloride, an antihypertensive, cardio-protective agent and slow channel blocker were used as a model drug to evaluate its release characteristics from different pellets formulations. Diltiazem Hydrochloride sustained release pellets were prepared by drug loading (drug binder suspension) on neutral pellets followed by different percentages of spraying, i.e. 2%,4%, 6%, 8% and 10% coating suspension using ethyl cellulose and hydroxy-propyl methyl cellulose polymer in a fixed 85:15 ratios respectively. The in vitro dissolution studies of Diltiazem Hydrochloride from these sustained release pellets were carried out in pH 7.2 phosphate buffer for 1, 2, 3, 4, 5, 6, 7, and 8 hrs using USP-I method. Statistically, significant differences were found among the drug release profile from different formulations. Polymer content with the highest concentration of Ethyl cellulose on the pellets shows the highest release retarding rate of the drug. The retarding capacity decreases with the decreased concentration of ethyl cellulose. The release mechanism was explored and explained with zero order, first order, Higuchi and Korsmeyer’s equations. Finally, the study showed that the profile and kinetics of drug release were functions of polymer type, polymer concentration & the physico-chemical properties of the drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=diltiazem%20hydrochloride" title="diltiazem hydrochloride">diltiazem hydrochloride</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=hydroxy%20propyl%20methyl%20cellulose" title=" hydroxy propyl methyl cellulose"> hydroxy propyl methyl cellulose</a>, <a href="https://publications.waset.org/abstracts/search?q=release%20kinetics" title=" release kinetics"> release kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=sustained%20release%20pellets" title=" sustained release pellets"> sustained release pellets</a> </p> <a href="https://publications.waset.org/abstracts/21180/effect-of-ethyl-cellulose-and-hydroxy-propyl-methyl-cellulose-polymer-on-the-release-profile-of-diltiazem-hydrochloride-sustained-release-pellets" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21180.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">414</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1831</span> Formulation and Evaluation of Niosomes Containing an Antihypertensive Drug</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj">Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini"> Vipin Saini</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Niosomes were formulated with an aim of enhancing the oral bioavailability of losartan potassium and formulated in different molar ratios of surfactant, cholesterol and dicetyl phosphate. The formulated niosomes were found in range of 54.98 µm to 107.85 µm in size. Formulations with 1:1 ratio of surfactant and cholesterol have shown maximum entrapment efficiencies. Niosomes with sorbitan monostearate showed maximum drug release and zero order release kinetics, at the end of 24 hours. The <em>in vivo</em> study has shown the significant enhancement in oral bioavailability of losartan potassium in rats, after a dose of 10 mg/kg. The average relative bioavailability in relation with pure drug solution was found 2.56, indicates more than two fold increase in oral bioavailability. A significant increment in MRT reflects the release retarding ability of the vesicles. In conclusion, niosomes could be a promising delivery of losartan potassium with improved oral bioavailability and prolonged release profiles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=non-ionic%20surfactant%20vesicles" title="non-ionic surfactant vesicles">non-ionic surfactant vesicles</a>, <a href="https://publications.waset.org/abstracts/search?q=losartan%20potassium" title=" losartan potassium"> losartan potassium</a>, <a href="https://publications.waset.org/abstracts/search?q=oral%20bioavailability" title=" oral bioavailability"> oral bioavailability</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a> </p> <a href="https://publications.waset.org/abstracts/37426/formulation-and-evaluation-of-niosomes-containing-an-antihypertensive-drug" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/37426.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">354</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1830</span> Kinetic Analysis of Wood Pellets by Isothermal Calorimetry for Evaluating its Self-heating Potential</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Can%20Yao">Can Yao</a>, <a href="https://publications.waset.org/abstracts/search?q=Chang%20Dong%20Sheng"> Chang Dong Sheng</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The heat released by wood pellets during storage will cause self-heating and even self-ignition. In this work, the heat release rates of pine, fir wood and mahogany pellets at 30–70℃ were measured by TAM air isothermal calorimeter, and the kinetic analysis was performed by iso-conversion ratio and non-steady-state methods to evaluate its self-heating potential. The results show that the reaction temperature can significantly affect the heat release rate. The higher the temperature, the greater the heat release rate. The heat release rates of different kinds of wood pellets are obviously different, and the order of the heat release rates for the three pellets at 70℃ is pine > fir wood > mahogany. The kinetic analysis of the iso-conversion ratio method indicates that the distribution of activation energy for pine, fir wood and mahogany pellets under the release of 0.1–1.0 J/g specific heat are 58–102 kJ/mol, 59–108 kJ/mol and 59–112 kJ/mol, respectively. Their activation energies obtained from the non-steady-state kinetic analysis are 13.43 kJ/mol, 19.19 kJ/mol and 21.09 kJ/mol, respectively. Both kinetic analyses show that the magnitude of self-heating risk for the three pellet fuels is pine pellets > fir wood pellets > mahogany pellets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=isothermal%20calorimeter" title="isothermal calorimeter">isothermal calorimeter</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetics" title=" kinetics"> kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=self-heating" title=" self-heating"> self-heating</a>, <a href="https://publications.waset.org/abstracts/search?q=wood%20pellets" title=" wood pellets"> wood pellets</a> </p> <a href="https://publications.waset.org/abstracts/147219/kinetic-analysis-of-wood-pellets-by-isothermal-calorimetry-for-evaluating-its-self-heating-potential" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/147219.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">173</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1829</span> The Role of Long-Chain Ionic Surfactants on Extending Drug Delivery from Contact Lenses</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Cesar%20Torres">Cesar Torres</a>, <a href="https://publications.waset.org/abstracts/search?q=Robert%20Briber"> Robert Briber</a>, <a href="https://publications.waset.org/abstracts/search?q=Nam%20Sun%20Wang"> Nam Sun Wang</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Eye drops are the most commonly used treatment for short-term and long-term ophthalmic diseases. However, eye drops could deliver only about 5% of the functional ingredients contained in a burst dosage. To address the limitations of eye drops, the use of therapeutic contact lenses has been introduced. Drug-loaded contact lenses provide drugs a longer residence time in the tear film and hence, decrease the potential risk of side effects. Nevertheless, a major limitation of contact lenses as drug delivery devices is that most of the drug absorbed is released within the first few hours. This fact limits their use for extended release. The present study demonstrates the application of long-alkyl chain ionic surfactants on extending drug release kinetics from commercially available silicone hydrogel contact lenses. In vitro release experiments were carried by immersing drug-containing contact lenses in phosphate buffer saline at physiological pH. The drug concentration as a function of time was monitored using ultraviolet-visible spectroscopy. The results of the study demonstrate that release kinetics is dependent on the ionic surfactant weight percent in the contact lenses, and on the length of the hydrophobic alkyl chain of the ionic surfactants. The use of ionic surfactants in contact lenses can extend the delivery of drugs from a few hours to a few weeks, depending on the physicochemical properties of the drugs. Contact lenses embedded with ionic surfactants could be potential biomaterials to be used for extended drug delivery and in the treatment of ophthalmic diseases. However, ocular irritation and toxicity studies would be needed to evaluate the safety of the approach. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=contact%20lenses" title="contact lenses">contact lenses</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title=" controlled release"> controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=ionic%20surfactant" title=" ionic surfactant"> ionic surfactant</a> </p> <a href="https://publications.waset.org/abstracts/107530/the-role-of-long-chain-ionic-surfactants-on-extending-drug-delivery-from-contact-lenses" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/107530.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">143</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1828</span> Synthesis and Characterization of PH Sensitive Hydrogel and Its Application in Controlled Drug Release of Tramadol</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Naima%20Bouslah">Naima Bouslah</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Bounabi"> Leila Bounabi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farid%20Ouazib"> Farid Ouazib</a>, <a href="https://publications.waset.org/abstracts/search?q=Nabila%20Haddadine"> Nabila Haddadine</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Conventional release dosage forms are known to provide an immediate release of the drug. Controlling the rate of drug release from polymeric matrices is very important for a number of applications, particularly in the pharmaceutical area. Hydrogels are polymers in three-dimensional network arrangement, which can absorb and retain large amounts of water without dissolution. They have been frequently used to develop controlled released formulations for oral administration because they can extend the duration of drug release and thus reduce dose to be administrated improving patient compliance. Tramadol is an opioid pain medication used to treat moderate to moderately severe pain. When taken as an immediate-release oral formulation, the onset of pain relief usually occurs within about an hour. In the present work, we synthesized pH-responsive hydrogels of (hydroxyl ethyl methacrylate-co-acrylic acid), (HEMA-AA) for control drug delivery of tramadol in the gastro-intestinal tractus. The hydrogels with different acrylic acid content, were synthesized by free radical polymerization and characterized by FTIR spectroscopy, X ray diffraction analysis (XRD), differential scanning calorimetry (DSC) and thermo gravimetric analysis (TGA). FTIR spectroscopy has shown specific hydrogen bonding interactions between the carbonyl groups of the hydrogels and hydroxyl groups of tramadol. Both the XRD and DSC studies revealed that the introduction of tramadol in the hydrogel network induced the amorphization of the drug. The swelling behaviour, absorptive kinetics and the release kinetics of tramadol in simulated gastric fluid (pH 1.2) and in simulated intestinal fluid (pH 7.4) were also investigated. The hydrogels exhibited pH-responsive behavior in the swelling study. The (HEMA-AA) hydrogel swelling was much higher in pH =7.4 medium. The tramadol release was significantly increased when pH of the medium was changed from simulated gastric fluid (pH 1.2) to simulated intestinal fluid (pH 7.4). Using suitable mathematical models, the apparent diffusional coefficients and the corresponding kinetic parameters have been calculated. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=biopolymres" title="biopolymres">biopolymres</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogels" title=" hydrogels"> hydrogels</a>, <a href="https://publications.waset.org/abstracts/search?q=tramadol" title=" tramadol"> tramadol</a> </p> <a href="https://publications.waset.org/abstracts/28153/synthesis-and-characterization-of-ph-sensitive-hydrogel-and-its-application-in-controlled-drug-release-of-tramadol" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/28153.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">358</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1827</span> Formulation of Extended-Release Ranolazine Tablet and Investigation Its Stability in the Accelerated Stability Condition at 40⁰C and 75% Humidity</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of Ranolazine in the form of extended-release tablet in 500 mg dosage form was performed using Eudragit L100-55 as a retarding agent. Drug-release profiles were investigated in comparison with the reference Ranexa extended-release 500 mg tablet. F₂ and f₁ were calculated as 64.16 and 8.53, respectively. According to Peppas equation, the release of drug is controlled by diffusion (n=0.5). The tablets were put into accelerated stability conditions (40 °C, 75% humidity) for 3 and 6 months. The dissolution release profiles and other physical and chemical characteristics of the tablets confirmed the robustness and stability of formulation in this condition. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title="drug release">drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=extended-release%20tablet" title=" extended-release tablet"> extended-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=ranolazine" title=" ranolazine"> ranolazine</a>, <a href="https://publications.waset.org/abstracts/search?q=stability" title=" stability"> stability</a> </p> <a href="https://publications.waset.org/abstracts/127040/formulation-of-extended-release-ranolazine-tablet-and-investigation-its-stability-in-the-accelerated-stability-condition-at-40c-and-75-humidity" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/127040.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">155</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1826</span> Delivery of Positively Charged Proteins Using Hyaluronic Acid Microgels</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Elaheh%20Jooybar">Elaheh Jooybar</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20J.%20Abdekhodaie"> Mohammad J. Abdekhodaie</a>, <a href="https://publications.waset.org/abstracts/search?q=Marcel%20Karperien"> Marcel Karperien</a>, <a href="https://publications.waset.org/abstracts/search?q=Pieter%20J.%20Dijkstra"> Pieter J. Dijkstra</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, hyaluronic acid (HA) microgels were developed for the goal of protein delivery. First, a hyaluronic acid-tyramine conjugate (HA-TA) was synthesized with a degree of substitution of 13 TA moieties per 100 disaccharide units. Then, HA-TA microdroplets were produced using a water in oil emulsion method and crosslinked in the presence of horseradish peroxidase (HRP) and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>). Loading capacity and the release kinetics of lysozyme and BSA, as model proteins, were investigated. It was shown that lysozyme, a cationic protein, can be incorporated efficiently in the HA microgels, while the loading efficiency for BSA, as a negatively charged protein, is low. The release profile of lysozyme showed a sustained release over a period of one month. The results demonstrated that the HA-TA microgels are a good carrier for spatial delivery of cationic proteins for biomedical applications. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=microgel" title="microgel">microgel</a>, <a href="https://publications.waset.org/abstracts/search?q=inverse%20emulsion" title=" inverse emulsion"> inverse emulsion</a>, <a href="https://publications.waset.org/abstracts/search?q=protein%20delivery" title=" protein delivery"> protein delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hyaluronic%20acid" title=" hyaluronic acid"> hyaluronic acid</a>, <a href="https://publications.waset.org/abstracts/search?q=crosslinking" title=" crosslinking"> crosslinking</a> </p> <a href="https://publications.waset.org/abstracts/94342/delivery-of-positively-charged-proteins-using-hyaluronic-acid-microgels" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/94342.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">169</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1825</span> Design, Development and Evaluation of Ketoconazole Loaded Nanosponges in Hydrogel for the Management of Topical Fungal Infections</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nagasamy%20Venkatesh%20Dhandapani">Nagasamy Venkatesh Dhandapani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This work aims at investigating the use of β-Cyclodextrin as a cross linker, in an attempt to formulate nanosponges containing ketoconazole. The nanosponges were prepared by cross-linking method. The excipients used in this study did not alter the physicochemical properties of a drug as revealed by FTIR spectroscopy. Studies on various formulation variables revealed that all the variables are inter-related with the formulation. The ideal batch among the formulation was selected based on the higher entrapment efficiency and drug loading. The in vitro release studies of ketoconazole nanosponges in hydrogel exhibited a sustained release over a period of 24 hours. Mathematical analysis of drug release from the formulation followed non-Fickian diffusion obeying first order kinetics. The anti-fungal activity of the formulation exhibited better zone of inhibition when compared to pure drug (ketoconazole) against Tinea corporis. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=nanosponges" title="nanosponges">nanosponges</a>, <a href="https://publications.waset.org/abstracts/search?q=beta-cyclodextrin" title=" beta-cyclodextrin"> beta-cyclodextrin</a>, <a href="https://publications.waset.org/abstracts/search?q=ketoconazole" title=" ketoconazole"> ketoconazole</a>, <a href="https://publications.waset.org/abstracts/search?q=tinea%20corporis" title=" tinea corporis"> tinea corporis</a> </p> <a href="https://publications.waset.org/abstracts/103489/design-development-and-evaluation-of-ketoconazole-loaded-nanosponges-in-hydrogel-for-the-management-of-topical-fungal-infections" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/103489.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">157</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1824</span> Design and Development of Sustained Release Floating Tablet of Stavudine </h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Surajj%20Sarode">Surajj Sarode</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20Vidya%20Sagar"> G. Vidya Sagar</a>, <a href="https://publications.waset.org/abstracts/search?q=G.%20P.%20Vadnere"> G. P. Vadnere</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The purpose of the present study was to prolong the gastric residence time of Stavudine by developing gastric floating drug delivery system (GFDDS). Moreover, to study influence of different polymers on its release rate using gas-forming agents, like sodium bicarbonate, citric acid. Floating tablets were prepared by wet granulation method using PVP K-30 as a binder and the other polymers include Pullulan Gum, HPMC K100M, six different formulations with the varying concentrations of polymers were prepared and the tablets were evaluated in terms of their pre-compression parameters like bulk density, tapped density, Haunsner ratio, angle of repose, compressibility index, post compression physical characteristics, in vitro release, buoyancy, floating lag time (FLT), total floating time (TFT) and swelling index. All the formulations showed good floating lag time i.e. less than 3 mins. The batch containing combination of Pullulan Gum and HPMC 100M (i.e. F-6) showed total floating lag time more than 12 h., the highest swelling index among all the prepared batches. The drug release was found to follow zero order kinetics. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Suavudine" title="Suavudine">Suavudine</a>, <a href="https://publications.waset.org/abstracts/search?q=floating" title=" floating"> floating</a>, <a href="https://publications.waset.org/abstracts/search?q=total%20floating%20time%20%28TFT%29" title=" total floating time (TFT)"> total floating time (TFT)</a>, <a href="https://publications.waset.org/abstracts/search?q=gastric%20residence" title=" gastric residence"> gastric residence</a> </p> <a href="https://publications.waset.org/abstracts/13372/design-and-development-of-sustained-release-floating-tablet-of-stavudine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/13372.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">397</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1823</span> Solid Dispersions of Cefixime Using β-Cyclodextrin: Characterization and in vitro Evaluation</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Nagasamy%20Venkatesh%20Dhandapani">Nagasamy Venkatesh Dhandapani</a>, <a href="https://publications.waset.org/abstracts/search?q=Amged%20Awad%20El-Gied"> Amged Awad El-Gied</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Cefixime, a BCS class II drug, is insoluble in water but freely soluble in acetone and in alcohol. The aqueous solubility of cefixime in water is poor and exhibits exceptionally slow and intrinsic dissolution rate. In the present study, cefixime and β-Cyclodextrin (β-CD) solid dispersions were prepared with a view to study the effect and influence of β-CD on the solubility and dissolution rate of this poorly aqueous soluble drug. Phase solubility profile revealed that the solubility of cefixime was increased in the presence of β-CD and was classified as A<sub>L</sub>-type. Effect of variable, such as drug:carrier ratio, was studied. Physical characterization of the solid dispersion was characterized by Fourier transform infrared spectroscopy (FT-IR) and Differential scanning calorimetry (DSC). These studies revealed that a distinct loss of drug crystallinity in the solid molecular dispersions is ostensibly accounting for enhancement of dissolution rate in distilled water. The drug release from the prepared solid dispersion exhibited a first order kinetics. Solid dispersions of cefixime showed a 6.77 times fold increase in dissolution rate over the pure drug. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=%CE%B2-cyclodextrin" title="β-cyclodextrin">β-cyclodextrin</a>, <a href="https://publications.waset.org/abstracts/search?q=cefixime" title=" cefixime"> cefixime</a>, <a href="https://publications.waset.org/abstracts/search?q=dissolution" title=" dissolution"> dissolution</a>, <a href="https://publications.waset.org/abstracts/search?q=Kneading%20method" title=" Kneading method"> Kneading method</a>, <a href="https://publications.waset.org/abstracts/search?q=solid%20dispersions" title=" solid dispersions"> solid dispersions</a>, <a href="https://publications.waset.org/abstracts/search?q=release%20kinetics" title=" release kinetics"> release kinetics</a> </p> <a href="https://publications.waset.org/abstracts/58364/solid-dispersions-of-cefixime-using-v-cyclodextrin-characterization-and-in-vitro-evaluation" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/58364.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1822</span> Calcein Release from Liposomes Mediated by Phospholipase A₂ Activity: Effect of Cholesterol and Amphipathic Di and Tri Blocks Copolymers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Marco%20Soto-Arriaza">Marco Soto-Arriaza</a>, <a href="https://publications.waset.org/abstracts/search?q=Eduardo%20Cena-Ahumada"> Eduardo Cena-Ahumada</a>, <a href="https://publications.waset.org/abstracts/search?q=Jaime%20Melendez-Rojel"> Jaime Melendez-Rojel</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Background: Liposomes have been widely used as a model of lipid bilayer to study the physicochemical properties of biological membrane, encapsulation, transport and release of different molecules. Furthermore, extensive research has focused on improving the efficiency in the transport of drugs, developing tools that improve the release of the encapsulated drug from liposomes. In this context, the enzymatic activity of PLA₂, despite having been shown to be an effective tool to promote the release of drugs from liposomes, is still an open field of research. Aim: The aim of the present study is to explore the effect of cholesterol (Cho) and amphipathic di- and tri-block copolymers, on calcein release mediated by enzymatic activity of PLA2 in Dipalmitoylphosphatidylcholine (DPPC) liposomes under physiological conditions. Methods: Different dispersions of DPPC, cholesterol, di-block POE₄₅-PCL₅₂ or tri-block PCL₁₂-POE₄₅-PCL₁₂ were prepared by the extrusion method after five freezing/thawing cycles; in Phosphate buffer 10mM pH 7.4 in presence of calcein. DPPC liposomes/Calcein were centrifuged at 15000rpm 10 min to separate free calcein. Enzymatic activity assays of PLA₂ were performed at 37°C using the TBS buffer pH 7.4. The size distribution, polydispersity, Z-potential and Calcein encapsulation of DPPC liposomes was monitored. Results: PLA₂ activity showed a slower kinetic of calcein release up to 20 mol% of cholesterol, evidencing a minimum at 10 mol% and then a maximum at 18 mol%. Regardless of the percentage of cholesterol, up to 18 mol% a one-hundred percentage release of calcein was observed. At higher cholesterol concentrations, PLA₂ showed to be inefficient or not to be involved in calcein release. In assays where copolymers were added in a concentration lower than their cmc, a similar behavior to those showed in the presence of Cho was observed, that is a slower kinetic in calcein release. In both experimental approaches, a one-hundred percentage of calcein release was observed. PLA₂ was shown to be sensitive to the 4-(4-Octadecylphenyl)-4-oxobutenoic acid inhibitor and calcium, reducing the release of calcein to 0%. Cell viability of HeLa cells decreased 7% in the presence of DPPC liposomes after 3 hours of incubation and 17% and 23% at 5 and 15 hours, respectively. Conclusion: Calcein release from DPPC liposomes, mediated by PLA₂ activity, depends on the percentage of cholesterol and the presence of copolymers. Both, cholesterol up to 20 mol% and copolymers below it cmc could be applied to the regulation of the kinetics of antitumoral drugs release without inducing cell toxicity per se. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=amphipathic%20copolymers" title="amphipathic copolymers">amphipathic copolymers</a>, <a href="https://publications.waset.org/abstracts/search?q=calcein%20release" title=" calcein release"> calcein release</a>, <a href="https://publications.waset.org/abstracts/search?q=cholesterol" title=" cholesterol"> cholesterol</a>, <a href="https://publications.waset.org/abstracts/search?q=DPPC%20liposome" title=" DPPC liposome"> DPPC liposome</a>, <a href="https://publications.waset.org/abstracts/search?q=phospholipase%20A%E2%82%82" title=" phospholipase A₂"> phospholipase A₂</a> </p> <a href="https://publications.waset.org/abstracts/138744/calcein-release-from-liposomes-mediated-by-phospholipase-a2-activity-effect-of-cholesterol-and-amphipathic-di-and-tri-blocks-copolymers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/138744.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">163</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1821</span> The Optimization of Topical Antineoplastic Therapy Using Controlled Release Systems Based on Amino-functionalized Mesoporous Silica</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Lacramioara%20Ochiuz">Lacramioara Ochiuz</a>, <a href="https://publications.waset.org/abstracts/search?q=Aurelia%20Vasile"> Aurelia Vasile</a>, <a href="https://publications.waset.org/abstracts/search?q=Iulian%20Stoleriu"> Iulian Stoleriu</a>, <a href="https://publications.waset.org/abstracts/search?q=Cristina%20Ghiciuc"> Cristina Ghiciuc</a>, <a href="https://publications.waset.org/abstracts/search?q=Maria%20Ignat"> Maria Ignat</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Topical administration of chemotherapeutic agents (eg. carmustine, bexarotene, mechlorethamine etc.) in local treatment of cutaneous T-cell lymphoma (CTCL) is accompanied by multiple side effects, such as contact hypersensitivity, pruritus, skin atrophy or even secondary malignancies. A known method of reducing the side effects of anticancer agent is the development of modified drug release systems using drug incapsulation in biocompatible nanoporous inorganic matrices, such as mesoporous MCM-41 silica. Mesoporous MCM-41 silica is characterized by large specific surface, high pore volume, uniform porosity, and stable dispersion in aqueous medium, excellent biocompatibility, in vivo biodegradability and capacity to be functionalized with different organic groups. Therefore, MCM-41 is an attractive candidate for a wide range of biomedical applications, such as controlled drug release, bone regeneration, protein immobilization, enzymes, etc. The main advantage of this material lies in its ability to host a large amount of the active substance in uniform pore system with adjustable size in a mesoscopic range. Silanol groups allow surface controlled functionalization leading to control of drug loading and release. This study shows (I) the amino-grafting optimization of mesoporous MCM-41 silica matrix by means of co-condensation during synthesis and post-synthesis using APTES (3-aminopropyltriethoxysilane); (ii) loading the therapeutic agent (carmustine) obtaining a modified drug release systems; (iii) determining the profile of in vitro carmustine release from these systems; (iv) assessment of carmustine release kinetics by fitting on four mathematical models. Obtained powders have been described in terms of structure, texture, morphology thermogravimetric analysis. The concentration of the therapeutic agent in the dissolution medium has been determined by HPLC method. In vitro dissolution tests have been done using cell Enhancer in a 12 hours interval. Analysis of carmustine release kinetics from mesoporous systems was made by fitting to zero-order model, first-order model Higuchi model and Korsmeyer-Peppas model, respectively. Results showed that both types of highly ordered mesoporous silica (amino grafted by co-condensation process or post-synthesis) are thermally stable in aqueous medium. In what regards the degree of loading and efficiency of loading with the therapeutic agent, there has been noticed an increase of around 10% in case of co-condensation method application. This result shows that direct co-condensation leads to even distribution of amino groups on the pore walls while in case of post-synthesis grafting many amino groups are concentrated near the pore opening and/or on external surface. In vitro dissolution tests showed an extended carmustine release (more than 86% m/m) both from systems based on silica functionalized directly by co-condensation and after synthesis. Assessment of carmustine release kinetics revealed a release through diffusion from all studied systems as a result of fitting to Higuchi model. The results of this study proved that amino-functionalized mesoporous silica may be used as a matrix for optimizing the anti-cancer topical therapy by loading carmustine and developing prolonged-release systems. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=carmustine" title="carmustine">carmustine</a>, <a href="https://publications.waset.org/abstracts/search?q=silica" title=" silica"> silica</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled" title=" controlled"> controlled</a>, <a href="https://publications.waset.org/abstracts/search?q=release" title=" release "> release </a> </p> <a href="https://publications.waset.org/abstracts/42573/the-optimization-of-topical-antineoplastic-therapy-using-controlled-release-systems-based-on-amino-functionalized-mesoporous-silica" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42573.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">264</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1820</span> Effect of Swelling Pressure on Drug Release from Polyelectrolyte Micro-Hydrogel Particles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Mina%20Boroujerdi">Mina Boroujerdi</a>, <a href="https://publications.waset.org/abstracts/search?q=Javad%20Tavakoli"> Javad Tavakoli</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Hydrogels are extensively studied as matrices for the controlled release of drugs. To evaluate the mobility of embedded molecules, these drug delivery systems are usually characterized by release studies. In this contribution, an electronic device for swelling pressure measurement during drug release from hydrogel network was developed. Also, poly acrylic acid micro particles were prepared for prolonged and sustained controlled acetaminophen release. Effect of swelling pressure on drug release from micro particles studied under different environment pH in order to predict release profile in gastro-intestine medium. Swelling ratio and swelling pressure were measured in different pH. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=swelling%20pressure" title="swelling pressure">swelling pressure</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=hydrogel" title=" hydrogel"> hydrogel</a>, <a href="https://publications.waset.org/abstracts/search?q=polyelectrolyte" title=" polyelectrolyte"> polyelectrolyte</a> </p> <a href="https://publications.waset.org/abstracts/54759/effect-of-swelling-pressure-on-drug-release-from-polyelectrolyte-micro-hydrogel-particles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/54759.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">299</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1819</span> Curcumin and Methotrexate Loaded Montmollilite Clay for Sustained Oral Drug Delivery Application</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Subrata%20Kar">Subrata Kar</a>, <a href="https://publications.waset.org/abstracts/search?q=Banani%20Kundu"> Banani Kundu</a>, <a href="https://publications.waset.org/abstracts/search?q=Papiya%20Nandy"> Papiya Nandy</a>, <a href="https://publications.waset.org/abstracts/search?q=Ruma%20Basu"> Ruma Basu</a>, <a href="https://publications.waset.org/abstracts/search?q=Sukhen%20Das"> Sukhen Das</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Natural montmorilollite clay is a common ingredient in pharmaceutical products, both as excipients and active support; hence considered as suitable candidate for Drug Delivery System. In this work, cationic detergent CTAB is used to increase the interlayer spacing of Na+-Montmoriollite clay to intercalate curcumin and methotrexate. Methotrexate is a folic acid antagonist, anti-proliferative and immunosuppressive agent; while curcumin is a bioactive constituent of rhizomes of Curcuma longa, possessing remarkable chemo-preventive and anti-inflammatory properties. The resultant inorganic-organic hybrids are characterized by X-ray diffraction (XRD), Infrared spectroscopy (FTIR) and Thermo Gravimetric Analysis (TGA) to confirm successful intercalation of curcumin and Methotrexate within clay layers. Pharmaceutical investigation of the hybrids is explored by studying the drug loading (%), encapsulation efficiency and release kinetics. Finally in-vitro studies are performed using cancer cells to find the effect of released curcumin to improve the sensitivity of clay bound methotrexate to ameliorate cell death compared to their effectiveness when used without the inorganic aluminosilicate vehicle. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=montmorillonite" title="montmorillonite">montmorillonite</a>, <a href="https://publications.waset.org/abstracts/search?q=methotrexate" title=" methotrexate"> methotrexate</a>, <a href="https://publications.waset.org/abstracts/search?q=curcumin" title=" curcumin"> curcumin</a>, <a href="https://publications.waset.org/abstracts/search?q=loading%20efficiency" title=" loading efficiency"> loading efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=release%20kinetics" title=" release kinetics"> release kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=anticancer%20activity" title=" anticancer activity"> anticancer activity</a> </p> <a href="https://publications.waset.org/abstracts/42753/curcumin-and-methotrexate-loaded-montmollilite-clay-for-sustained-oral-drug-delivery-application" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/42753.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">515</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1818</span> Controlling the Release of Cyt C and L- Dopa from pNIPAM-AAc Nanogel Based Systems</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Sulalit%20Bandyopadhyay">Sulalit Bandyopadhyay</a>, <a href="https://publications.waset.org/abstracts/search?q=Muhammad%20Awais%20Ashfaq%20Alvi"> Muhammad Awais Ashfaq Alvi</a>, <a href="https://publications.waset.org/abstracts/search?q=Anuvansh%20Sharma"> Anuvansh Sharma</a>, <a href="https://publications.waset.org/abstracts/search?q=Wilhelm%20R.%20Glomm"> Wilhelm R. Glomm</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Release of drugs from nanogels and nanogel-based systems can occur under the influence of external stimuli like temperature, pH, magnetic fields and so on. pNIPAm-AAc nanogels respond to the combined action of both temperature and pH, the former being mostly determined by hydrophilic-to-hydrophobic transitions above the volume phase transition temperature (VPTT), while the latter is controlled by the degree of protonation of the carboxylic acid groups. These nanogels based systems are promising candidates in the field of drug delivery. Combining nanogels with magneto-plasmonic nanoparticles (NPs) introduce imaging and targeting modalities along with stimuli-response in one hybrid system, thereby incorporating multifunctionality. Fe@Au core-shell NPs possess optical signature in the visible spectrum owing to localized surface plasmon resonance (LSPR) of the Au shell, and superparamagnetic properties stemming from the Fe core. Although there exist several synthesis methods to control the size and physico-chemical properties of pNIPAm-AAc nanogels, yet, there is no comprehensive study that highlights the dependence of incorporation of one or more layers of NPs to these nanogels. In addition, effective determination of volume phase transition temperature (VPTT) of the nanogels is a challenge which complicates their uses in biological applications. Here, we have modified the swelling-collapse properties of pNIPAm-AAc nanogels, by combining with Fe@Au NPs using different solution based methods. The hydrophilic-hydrophobic transition of the nanogels above the VPTT has been confirmed to be reversible. Further, an analytical method has been developed to deduce the average VPTT which is found to be 37.3°C for the nanogels and 39.3°C for nanogel coated Fe@Au NPs. An opposite swelling –collapse behaviour is observed for the latter where the Fe@Au NPs act as bridge molecules pulling together the gelling units. Thereafter, Cyt C, a model protein drug and L-Dopa, a drug used in the clinical treatment of Parkinson’s disease were loaded separately into the nanogels and nanogel coated Fe@Au NPs, using a modified breathing-in mechanism. This gave high loading and encapsulation efficiencies (L Dopa: ~9% and 70µg/mg of nanogels, Cyt C: ~30% and 10µg/mg of nanogels respectively for both the drugs. The release kinetics of L-Dopa, monitored using UV-vis spectrophotometry was observed to be rather slow (over several hours) with highest release happening under a combination of high temperature (above VPTT) and acidic conditions. However, the release of L-Dopa from nanogel coated Fe@Au NPs was the fastest, accounting for release of almost 87% of the initially loaded drug in ~30 hours. The chemical structure of the drug, drug incorporation method, location of the drug and presence of Fe@Au NPs largely alter the drug release mechanism and the kinetics of these nanogels and Fe@Au NPs coated with nanogels. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=controlled%20release" title="controlled release">controlled release</a>, <a href="https://publications.waset.org/abstracts/search?q=nanogels" title=" nanogels"> nanogels</a>, <a href="https://publications.waset.org/abstracts/search?q=volume%20phase%20transition%20temperature" title=" volume phase transition temperature"> volume phase transition temperature</a>, <a href="https://publications.waset.org/abstracts/search?q=l-dopa" title=" l-dopa"> l-dopa</a> </p> <a href="https://publications.waset.org/abstracts/41229/controlling-the-release-of-cyt-c-and-l-dopa-from-pnipam-aac-nanogel-based-systems" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/41229.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">331</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1817</span> Pyrolysis of Dursunbey Lignite and Pyrolysis Kinetics</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=H.%20S%C3%BCt%C3%A7%C3%BC">H. Sütçü</a>, <a href="https://publications.waset.org/abstracts/search?q=C.%20Efe"> C. Efe</a> </p> <p class="card-text"><strong>Abstract:</strong></p> In this study, pyrolysis characteristics of Dursunbey-Balıkesir lignite and its pyrolysis kinetics are examined. The pyrolysis experiments carried out at three different heating rates are performed by using thermogravimetric method. Kinetic parameters are calculated by Coats & Redfern kinetic model and the degree of pyrolysis process is determined for each of the heating rate. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=lignite" title="lignite">lignite</a>, <a href="https://publications.waset.org/abstracts/search?q=thermogravimetric%20analysis" title=" thermogravimetric analysis"> thermogravimetric analysis</a>, <a href="https://publications.waset.org/abstracts/search?q=pyrolysis" title=" pyrolysis"> pyrolysis</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetics" title=" kinetics"> kinetics</a> </p> <a href="https://publications.waset.org/abstracts/61724/pyrolysis-of-dursunbey-lignite-and-pyrolysis-kinetics" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/61724.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">367</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1816</span> Formulation of Extended-Release Gliclazide Tablet Using a Mathematical Model for Estimation of Hypromellose</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Farzad%20Khajavi">Farzad Khajavi</a>, <a href="https://publications.waset.org/abstracts/search?q=Farzaneh%20Jalilfar"> Farzaneh Jalilfar</a>, <a href="https://publications.waset.org/abstracts/search?q=Faranak%20Jafari"> Faranak Jafari</a>, <a href="https://publications.waset.org/abstracts/search?q=Leila%20Shokrani"> Leila Shokrani</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Formulation of gliclazide in the form of extended-release tablet in 30 and 60 mg dosage forms was performed using hypromellose (HPMC K4M) as a retarding agent. Drug-release profiles were investigated in comparison with references Diamicron MR 30 and 60 mg tablets. The effect of size of powder particles, the amount of hypromellose in formulation, hardness of tablets, and also the effect of halving the tablets were investigated on drug release profile. A mathematical model which describes hypromellose behavior in initial times of drug release was proposed for the estimation of hypromellose content in modified-release gliclazide 60 mg tablet. This model is based on erosion of hypromellose in dissolution media. The model is applicable to describe release profiles of insoluble drugs. Therefore, by using dissolved amount of drug in initial times of dissolution and the model, the amount of hypromellose in formulation can be predictable. The model was used to predict the HPMC K4M content in modified-release gliclazide 30 mg and extended-release quetiapine 200 mg tablets. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Gliclazide" title="Gliclazide">Gliclazide</a>, <a href="https://publications.waset.org/abstracts/search?q=hypromellose" title=" hypromellose"> hypromellose</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20release" title=" drug release"> drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=modified-release%20tablet" title=" modified-release tablet"> modified-release tablet</a>, <a href="https://publications.waset.org/abstracts/search?q=mathematical%20model" title=" mathematical model"> mathematical model</a> </p> <a href="https://publications.waset.org/abstracts/75442/formulation-of-extended-release-gliclazide-tablet-using-a-mathematical-model-for-estimation-of-hypromellose" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/75442.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">222</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1815</span> Chemical Kinetics and Computational Fluid-Dynamics Analysis of H2/CO/CO2/CH4 Syngas Combustion and NOx Formation in a Micro-Pilot-Ignited Supercharged Dual Fuel Engine</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ulugbek%20Azimov">Ulugbek Azimov</a>, <a href="https://publications.waset.org/abstracts/search?q=Nearchos%20Stylianidis"> Nearchos Stylianidis</a>, <a href="https://publications.waset.org/abstracts/search?q=Nobuyuki%20Kawahara"> Nobuyuki Kawahara</a>, <a href="https://publications.waset.org/abstracts/search?q=Eiji%20Tomita"> Eiji Tomita</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A chemical kinetics and computational fluid-dynamics (CFD) analysis was performed to evaluate the combustion of syngas derived from biomass and coke-oven solid feedstock in a micro-pilot ignited supercharged dual-fuel engine under lean conditions. For this analysis, a new reduced syngas chemical kinetics mechanism was constructed and validated by comparing the ignition delay and laminar flame speed data with those obtained from experiments and other detail chemical kinetics mechanisms available in the literature. The reaction sensitivity analysis was conducted for ignition delay at elevated pressures in order to identify important chemical reactions that govern the combustion process. The chemical kinetics of NOx formation was analyzed for H2/CO/CO2/CH4 syngas mixtures by using counter flow burner and premixed laminar flame speed reactor models. The new mechanism showed a very good agreement with experimental measurements and accurately reproduced the effect of pressure, temperature and equivalence ratio on NOx formation. In order to identify the species important for NOx formation, a sensitivity analysis was conducted for pressures 4 bar, 10 bar and 16 bar and preheat temperature 300 K. The results show that the NOx formation is driven mostly by hydrogen based species while other species, such as N2, CO2 and CH4, have also important effects on combustion. Finally, the new mechanism was used in a multidimensional CFD simulation to predict the combustion of syngas in a micro-pilot-ignited supercharged dual-fuel engine and results were compared with experiments. The mechanism showed the closest prediction of the in-cylinder pressure and the rate of heat release (ROHR). <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=syngas" title="syngas">syngas</a>, <a href="https://publications.waset.org/abstracts/search?q=chemical%20kinetics%20mechanism" title=" chemical kinetics mechanism"> chemical kinetics mechanism</a>, <a href="https://publications.waset.org/abstracts/search?q=internal%20combustion%20engine" title=" internal combustion engine"> internal combustion engine</a>, <a href="https://publications.waset.org/abstracts/search?q=NOx%20formation" title=" NOx formation"> NOx formation</a> </p> <a href="https://publications.waset.org/abstracts/73746/chemical-kinetics-and-computational-fluid-dynamics-analysis-of-h2coco2ch4-syngas-combustion-and-nox-formation-in-a-micro-pilot-ignited-supercharged-dual-fuel-engine" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/73746.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">409</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1814</span> A Dislocation-Based Explanation to Quasi-Elastic Release in Shock Loaded Aluminum</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Song%20L.%20Yao">Song L. Yao</a>, <a href="https://publications.waset.org/abstracts/search?q=Ji%20D.%20Yu"> Ji D. Yu</a>, <a href="https://publications.waset.org/abstracts/search?q=Xiao%20Y.%20Pei"> Xiao Y. Pei</a> </p> <p class="card-text"><strong>Abstract:</strong></p> An explanation is introduced to study the quasi-elastic release phenomenon in shock compressed aluminum. A dislocation-based model, taking into account of dislocation substructures and evolutions, is applied to simulate the elastic-plastic response of both single crystal and polycrystalline aluminum. Simulated results indicate that dislocation immobilization during dynamic deformation results in a smooth increase of yield stress, which leads to the quasi-elastic release. While the generation of dislocations caused by plastic release wave results in the appearance of transition point between the quasi-elastic release and the plastic release in the profile. The quantities of calculated shear strength and dislocation density are in accordance with experimental result, which demonstrates the accuracy of our simulations. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=dislocation%20density" title="dislocation density">dislocation density</a>, <a href="https://publications.waset.org/abstracts/search?q=quasi-elastic%20release" title=" quasi-elastic release"> quasi-elastic release</a>, <a href="https://publications.waset.org/abstracts/search?q=wave%20profile" title=" wave profile"> wave profile</a>, <a href="https://publications.waset.org/abstracts/search?q=shock%20wave" title=" shock wave"> shock wave</a> </p> <a href="https://publications.waset.org/abstracts/70941/a-dislocation-based-explanation-to-quasi-elastic-release-in-shock-loaded-aluminum" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/70941.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">282</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1813</span> Design and Development of Buccal Delivery System for Atenolol Tablets by Using Different Bioadhesive Polymers</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Venkatalakshmi%20Ranganathan">Venkatalakshmi Ranganathan</a>, <a href="https://publications.waset.org/abstracts/search?q=Ong%20Hsin%20Ju"> Ong Hsin Ju</a>, <a href="https://publications.waset.org/abstracts/search?q=Tan%20Yinn%20Ming"> Tan Yinn Ming</a>, <a href="https://publications.waset.org/abstracts/search?q=Lim%20Kien%20Sin"> Lim Kien Sin</a>, <a href="https://publications.waset.org/abstracts/search?q=Wong%20Man%20Ting"> Wong Man Ting</a>, <a href="https://publications.waset.org/abstracts/search?q=Venkata%20Srikanth%20Meka"> Venkata Srikanth Meka </a> </p> <p class="card-text"><strong>Abstract:</strong></p> The mucoadhesive buccal tablet is an oral drug delivery system which attached to the buccal surface for direct drug absorption into the systemic circulation and the unidirectional drug release is ensured by formulating a hydrophobic backing layer. The objective of present study was to formulate mucoadhesive atenolol bilayer buccal tablets by using sodium alginate, hydroxyethyl cellulose, and xanthan gum as mucoadhesive polymer and the technique applied was direct compression method. Ethyl cellulose was used as backing layer of the tablet. FTIR and DSC analysis were carried out to identify the drug polymer interactions. The prepared tablets were evaluated for physicochemical parameters, ex vivo mucoadhesion time and in-vitro drug release. The formulated tablets showed the average surface pH 6-7 which is favourable for oral mucosa. The formulation containing sodium alginate showed more than 90 % of drug release at the end of the 7 hours in vitro dissolution studies. The formulation containing xanthan gum showed more than 8 hours of mucoadhesion time and all formulation exhibited non fickian release kinetics. The present study indicates enormous potential of erodible mucoadhesive buccal tablet containing atenolol for systemic delivery with an added advantage of circumventing the hepatic first pass metabolism. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=atenolol" title="atenolol">atenolol</a>, <a href="https://publications.waset.org/abstracts/search?q=mucoadhesion" title=" mucoadhesion"> mucoadhesion</a>, <a href="https://publications.waset.org/abstracts/search?q=in%20vitro%20drug%20release" title=" in vitro drug release"> in vitro drug release</a>, <a href="https://publications.waset.org/abstracts/search?q=direct%20compression" title=" direct compression"> direct compression</a>, <a href="https://publications.waset.org/abstracts/search?q=ethyl%20cellulose" title=" ethyl cellulose"> ethyl cellulose</a> </p> <a href="https://publications.waset.org/abstracts/21532/design-and-development-of-buccal-delivery-system-for-atenolol-tablets-by-using-different-bioadhesive-polymers" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/21532.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">619</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1812</span> Effect of Two Cooking Methods on Kinetics of Polyphenol Content, Flavonoid Content and Color of a Tunisian Meal: Molokheiya (Corchorus olitorius)</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=S.%20Njoumi">S. Njoumi</a>, <a href="https://publications.waset.org/abstracts/search?q=L.%20Ben%20Haj%20Said"> L. Ben Haj Said</a>, <a href="https://publications.waset.org/abstracts/search?q=M.%20J.%20Amiot"> M. J. Amiot</a>, <a href="https://publications.waset.org/abstracts/search?q=S.%20Bellagha"> S. Bellagha</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The main objective of this research was to establish the kinetics of variation of total polyphenol content (TPC) and total flavonoid content (TFC) in Tunisian Corchorus olitorius powder and in a traditional home cooked-meal (Molokheiya) when using stewing and stir-frying as cooking methods, but also to compare the effect of these two common cooking practices on water content, TPC, TFC and color. The L*, a* and b* coordinates values of the Molokheiya varied from 24.955±0.039 to 21.301±0.036, from -1.556±0.048 to 0.23±0.026 and from 5.675±0.052 to 6.313±0.103 when using stewing and from 21.328±0.025 to 20.56±0.021, from -1.093± 0.011to 0.121±0.007 and from 5.708±0.020 to 6.263±0.007 when using stir-frying, respectively. TPC and TFC increased during cooking. TPC of Molokheiya varied from 29.852±0.866 mg GAE/100 g to 220.416±0.519 mg GAE/100 g after 150 min of stewing and from 25.257±0.259 mg GAE/100 g to 208.897 ±0.173 mg GAE/100 g using stir-frying method during 150 min. TFC of Molokheiya varied from 48.229±1.47 mg QE/100 g to 843.802±1.841 mg QE/100 g when using stewing and from 37.031± 0.368 mg QE/100 g to 775.312±0.736 mg QE/100 g when using stir-frying. Kinetics followed similar curves in all cases but resulted in different final TPC and TFC. The shape of the kinetics curves suggests zero-order kinetics. The mathematical relations and the numerical approach used to model the kinetics of polyphenol and flavonoid contents in Molokheiya are described. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=Corchorus%20olitorius" title="Corchorus olitorius">Corchorus olitorius</a>, <a href="https://publications.waset.org/abstracts/search?q=Molokheiya" title=" Molokheiya"> Molokheiya</a>, <a href="https://publications.waset.org/abstracts/search?q=phenolic%20compounds" title=" phenolic compounds"> phenolic compounds</a>, <a href="https://publications.waset.org/abstracts/search?q=kinetic" title=" kinetic"> kinetic</a> </p> <a href="https://publications.waset.org/abstracts/29841/effect-of-two-cooking-methods-on-kinetics-of-polyphenol-content-flavonoid-content-and-color-of-a-tunisian-meal-molokheiya-corchorus-olitorius" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/29841.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">355</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1811</span> Drug-Based Nanoparticles: Comparative Study of the Effect Drug Type on Release Kinetics and Cell Viability</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Chukwudalu%20C.%20Nwazojie">Chukwudalu C. Nwazojie</a>, <a href="https://publications.waset.org/abstracts/search?q=Wole%20W.%20Soboyejo"> Wole W. Soboyejo</a>, <a href="https://publications.waset.org/abstracts/search?q=John%20Obayemi"> John Obayemi</a>, <a href="https://publications.waset.org/abstracts/search?q=Ali%20Salifu%20Azeko"> Ali Salifu Azeko</a>, <a href="https://publications.waset.org/abstracts/search?q=Sandra%20M.%20Jusu"> Sandra M. Jusu</a>, <a href="https://publications.waset.org/abstracts/search?q=Chinyerem%20M.%20Onyekanne"> Chinyerem M. Onyekanne</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The conventional methods for the diagnosis and treatment of breast cancer include bulk systematic mammography, ultrasound, dynamic contrast-enhanced fast 3D gradient-echo (GRE) magnetic resonance imaging (MRI), surgery, chemotherapy, and radiotherapy. However, nanoparticles and drug-loaded polymer microspheres for disease (cancer) targeting and treatment have enormous potential to enhance the approaches that are used today. The goal is to produce an implantable biomedical device for localized breast cancer drug delivery within Africa and the world. The main advantage of localized delivery is that it reduces the amount of drug that is needed to have a therapeutic effect. Polymer blends of poly (D,L-lactide-co-glycolide) (PLGA) and polycaprolactone (PCL), which are biodegradable, is used as a drug excipient. This work focuses on the development of PLGA-PCL (poly (D,L-lactide-co-glycolide) (PLGA) blended with based injectable drug microspheres and are loaded with anticancer drugs (prodigiosin (PG), and paclitaxel (PTX) control) and also the conjugated forms of the drug functionalized with LHRH (luteinizing hormone-releasing hormone) (PG-LHRH, and PTX- LHRH control), using a single-emulsion solvent evaporation technique. The encapsulation was done in the presence of PLGA-PCL (as a polymer matrix) and poly-(vinyl alcohol) (PVA) (as an emulsifier). Comparative study of the various drugs release kinetics and degradation mechanisms of the PLGA-PCL with an encapsulated drug is achieved, and the implication of this study is for the potential application of prodigiosin PLGA-PCL loaded microparticles for controlled delivery of cancer drug and treatment to prevent the regrowth or locoregional recurrence, following surgical resection of triple-negative breast tumor. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=cancer" title="cancer">cancer</a>, <a href="https://publications.waset.org/abstracts/search?q=polymers" title=" polymers"> polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20kinetics" title=" drug kinetics"> drug kinetics</a>, <a href="https://publications.waset.org/abstracts/search?q=nanoparticles" title=" nanoparticles"> nanoparticles</a> </p> <a href="https://publications.waset.org/abstracts/110393/drug-based-nanoparticles-comparative-study-of-the-effect-drug-type-on-release-kinetics-and-cell-viability" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/110393.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">100</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1810</span> Encapsulation of Volatile Citronella Essential oil by Coacervation: Efficiency and Release Kinetic Study</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rafeqah%20Raslan">Rafeqah Raslan</a>, <a href="https://publications.waset.org/abstracts/search?q=Mastura%20AbdManaf"> Mastura AbdManaf</a>, <a href="https://publications.waset.org/abstracts/search?q=Junaidah%20Jai"> Junaidah Jai</a>, <a href="https://publications.waset.org/abstracts/search?q=Istikamah%20Subuki"> Istikamah Subuki</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20Najwa%20Mustapa"> Ana Najwa Mustapa</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The volatile citronella essential oil was encapsulated by simple coacervation and complex coacervation using gum Arabic and gelatin as wall material. Glutaraldehyde was used in the methodology as crosslinking agent. The citronella standard calibration graph was developed with R2 equal to 0.9523 for the accurate determination of encapsulation efficiency and release study. The release kinetic was analyzed based on Fick’s law of diffusion for polymeric system and linear graph of log fraction release over log time was constructed to determine the release rate constant, k and diffusion coefficient, n. Both coacervation methods in the present study produce encapsulation efficiency around 94%. The capsules morphology analysis supported the release kinetic mechanisms of produced capsules for both coacervation process. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=simple%20coacervation" title="simple coacervation">simple coacervation</a>, <a href="https://publications.waset.org/abstracts/search?q=complex%20coacervation" title=" complex coacervation"> complex coacervation</a>, <a href="https://publications.waset.org/abstracts/search?q=encapsulation%20efficiency" title=" encapsulation efficiency"> encapsulation efficiency</a>, <a href="https://publications.waset.org/abstracts/search?q=release%20kinetic%20study" title=" release kinetic study"> release kinetic study</a> </p> <a href="https://publications.waset.org/abstracts/14448/encapsulation-of-volatile-citronella-essential-oil-by-coacervation-efficiency-and-release-kinetic-study" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/14448.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">316</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1809</span> Preparation and Evaluation of Multiple Unit Tablets of Aceclofenac</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Vipin%20Saini">Vipin Saini</a>, <a href="https://publications.waset.org/abstracts/search?q=Sunil%20Kamboj"> Sunil Kamboj</a>, <a href="https://publications.waset.org/abstracts/search?q=Suman%20Bala"> Suman Bala</a>, <a href="https://publications.waset.org/abstracts/search?q=A.%20Pandurangan"> A. Pandurangan</a> </p> <p class="card-text"><strong>Abstract:</strong></p> The present research is aimed at fabrication of multiple-unit controlled-release tablet formulation of aceclofenac by employing acrylic polymers as the release controlling excipients for drug multi-particulates to achieve the desired objectives of maintaining the same controlled release characteristics as that prior to their compression into tablet. Various manufacturers are successfully manufacturing and marketing aceclofenac controlled release tablet by applying directly coating materials on the tablet. The basic idea behind development of such formulations was to employ aqueous acrylics polymers dispersion as an alternative to the existing approaches, wherein the forces of compression may cause twist of drug pellets, but do not have adverse effects on the drug release properties. Thus, the study was undertaken to illustrate manufacturing of controlled release aceclofenac multiple-unit tablet formulation. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=aceclofenac" title="aceclofenac">aceclofenac</a>, <a href="https://publications.waset.org/abstracts/search?q=multiple-unit%20tablets" title=" multiple-unit tablets"> multiple-unit tablets</a>, <a href="https://publications.waset.org/abstracts/search?q=acrylic%20polymers" title=" acrylic polymers"> acrylic polymers</a>, <a href="https://publications.waset.org/abstracts/search?q=controlled-release" title=" controlled-release"> controlled-release</a> </p> <a href="https://publications.waset.org/abstracts/1518/preparation-and-evaluation-of-multiple-unit-tablets-of-aceclofenac" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/1518.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">442</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1808</span> Self-Assembled Nano Aggregates Based On Polyaspartamide Graft Copolymers for pH-Controlled Release of Doxorubicin</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Van%20Tran%20Thi%20Thuy">Van Tran Thi Thuy</a>, <a href="https://publications.waset.org/abstracts/search?q=Cheol%20Won%20Lim"> Cheol Won Lim</a>, <a href="https://publications.waset.org/abstracts/search?q=Dukjoon%20Kim"> Dukjoon Kim</a> </p> <p class="card-text"><strong>Abstract:</strong></p> A series of biodegradable copolymers based on polyaspartamide (PASPAM) were synthesized by grafting hydrophilic O-(2-aminoethyl)-O'-methylpoly(ethylene glycol) (MPEG), hydrophobic cholic acid (CA), and pH-sensitive hydrazine (Hyd) segments on a PASPAM backbone. The hydrazine group was effectively cleaved to release doxorubicin (DOX) conjugated on PASPAM in an acidic environment. The chemical structure of the polymer and the degree of substitution of each graft segment were analyzed using FT-IR and 1H-NMR spectroscopy. The size of the MPEG/Hyd/CA-g-PASPAM copolymer self-aggregates was examined by dynamic light scattering (DLS) and transmission electron microscope (TEM). The mean diameter of the self - aggregates increased from 125 to 200 nm at pH 7.4, as the degree of substitution of CA increased from 10 to 20 %. The release kinetics of DOX was strongly affected by the pH of the releasing medium. While less than 30% of the DOX-loaded was released in about 30 h at pH 7.4, more than 60% was released at pH 5.0 within the same time. The viability tests of human breast cancer cells (MCF-7) and human embryonic kidney cells (293T) show the potential application of MPEG/Hyd/CA-g-PASPAM copolymer self-aggregates in the controlled intracellular delivery for cancer treatments. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=pH-sensitive" title="pH-sensitive">pH-sensitive</a>, <a href="https://publications.waset.org/abstracts/search?q=drug%20delivery" title=" drug delivery"> drug delivery</a>, <a href="https://publications.waset.org/abstracts/search?q=polyaspartamide" title=" polyaspartamide"> polyaspartamide</a>, <a href="https://publications.waset.org/abstracts/search?q=self-assembly" title=" self-assembly"> self-assembly</a>, <a href="https://publications.waset.org/abstracts/search?q=nano-aggregates" title=" nano-aggregates"> nano-aggregates</a> </p> <a href="https://publications.waset.org/abstracts/19167/self-assembled-nano-aggregates-based-on-polyaspartamide-graft-copolymers-for-ph-controlled-release-of-doxorubicin" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/19167.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">358</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1807</span> Release of PVA from PVA/PA Compounds into Water Solutions</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=J.%20Klofac">J. Klofac</a>, <a href="https://publications.waset.org/abstracts/search?q=P.%20Bazant"> P. Bazant</a>, <a href="https://publications.waset.org/abstracts/search?q=I.%20Kuritka"> I. Kuritka</a> </p> <p class="card-text"><strong>Abstract:</strong></p> This work is focused on the preparation of polymeric blend composed of polyamide (PA) and polyvinyl alcohol (PVA) with the intention to explore its basic characteristics important for potential use in medicine, especially for drug delivery systems. PA brings brilliant mechanical properties to the blend while PVA is inevitable due to its water solubility. Blend with different PA/PVA ratios were prepared and the release study of PVA into the water was carried out in a time interval 0-48 hours via the gravimetric method. The weight decrease is caused by the leaching of PVA domains what can be also followed by the optical and scanning electron microscopy. In addition, the thermal properties and the miscibility of blend components were evaluated by the differential scanning calorimeter. On the bases of performed experiments, it was found that the kinetics, continuity development and micro structure features of PA/PVA blends is strongly dependent on the blend composition and miscibility of its components. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=releas%20study" title="releas study">releas study</a>, <a href="https://publications.waset.org/abstracts/search?q=polyvinyl%20alcohol" title=" polyvinyl alcohol"> polyvinyl alcohol</a>, <a href="https://publications.waset.org/abstracts/search?q=polyamide%20morphology" title=" polyamide morphology"> polyamide morphology</a>, <a href="https://publications.waset.org/abstracts/search?q=polymeric%20blend" title=" polymeric blend"> polymeric blend</a> </p> <a href="https://publications.waset.org/abstracts/10731/release-of-pva-from-pvapa-compounds-into-water-solutions" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/10731.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">397</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1806</span> Release of Calcein from Liposomes Using Low and High Frequency Ultrasound</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Ghaleb%20A.%20Husseini">Ghaleb A. Husseini</a>, <a href="https://publications.waset.org/abstracts/search?q=Salma%20E.%20Ahmed"> Salma E. Ahmed</a>, <a href="https://publications.waset.org/abstracts/search?q=Hesham%20G.%20Moussa"> Hesham G. Moussa</a>, <a href="https://publications.waset.org/abstracts/search?q=Ana%20M.%20Martins"> Ana M. Martins</a>, <a href="https://publications.waset.org/abstracts/search?q=Mohammad%20Al-Sayah"> Mohammad Al-Sayah</a>, <a href="https://publications.waset.org/abstracts/search?q=Nasser%20Qaddoumi"> Nasser Qaddoumi </a> </p> <p class="card-text"><strong>Abstract:</strong></p> This abstract aims to investigate the use of targeted liposomes as anticancer drug carriers in vitro in combination with ultrasound applied as drug trigger; in order to reduce the side effects caused by traditional chemotherapy. Pegylated liposomes were used to encapsulate calcein and then release this model drug when 20-kHz, 40-kHz, 1-MHz and 3-MHz ultrasound were applied at different acoustic power densities. Fluorescence techniques were then used to measure the percent drug release of calcein from these targeted liposomes. Results showed that as the power density increases, at the four frequencies studied, the release of calcein also increased. Based on these results, we believe that ultrasound can be used to increase the rate and amount of chemotherapeutics release from liposomes. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=liposomes" title="liposomes">liposomes</a>, <a href="https://publications.waset.org/abstracts/search?q=calcein%20release" title=" calcein release"> calcein release</a>, <a href="https://publications.waset.org/abstracts/search?q=high%20frequency%20ultrasound" title=" high frequency ultrasound"> high frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=low%20frequency%20ultrasound" title=" low frequency ultrasound"> low frequency ultrasound</a>, <a href="https://publications.waset.org/abstracts/search?q=fluorescence%20techniques" title=" fluorescence techniques"> fluorescence techniques</a> </p> <a href="https://publications.waset.org/abstracts/24679/release-of-calcein-from-liposomes-using-low-and-high-frequency-ultrasound" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/24679.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">424</span> </span> </div> </div> <div class="card paper-listing mb-3 mt-3"> <h5 class="card-header" style="font-size:.9rem"><span class="badge badge-info">1805</span> Comparative Analysis of in vitro Release profile for Escitalopram and Escitalopram Loaded Nanoparticles</h5> <div class="card-body"> <p class="card-text"><strong>Authors:</strong> <a href="https://publications.waset.org/abstracts/search?q=Rashi%20Rajput">Rashi Rajput</a>, <a href="https://publications.waset.org/abstracts/search?q=Manisha%20Singh"> Manisha Singh</a> </p> <p class="card-text"><strong>Abstract:</strong></p> Escitalopram oxalate (ETP), an FDA approved antidepressant drug from the category of SSRI (selective serotonin reuptake inhibitor) and is used in treatment of general anxiety disorder (GAD), major depressive disorder (MDD).When taken orally, it is metabolized to S-demethylcitalopram (S-DCT) and S-didemethylcitalopram (S-DDCT) in the liver with the help of enzymes CYP2C19, CYP3A4 and CYP2D6. Hence, causing side effects such as dizziness, fast or irregular heartbeat, headache, nausea etc. Therefore, targeted and sustained drug delivery will be a helpful tool for increasing its efficacy and reducing side effects. The present study is designed for formulating mucoadhesive nanoparticle formulation for the same Escitalopram loaded polymeric nanoparticles were prepared by ionic gelation method and characterization of the optimised formulation was done by zeta average particle size (93.63nm), zeta potential (-1.89mV), TEM (range of 60nm to 115nm) analysis also confirms nanometric size range of the drug loaded nanoparticles along with polydispersibility index of 0.117. In this research, we have studied the in vitro drug release profile for ETP nanoparticles, through a semi permeable dialysis membrane. The three important characteristics affecting the drug release behaviour were – particle size, ionic strength and morphology of the optimised nanoparticles. The data showed that on increasing the particle size of the drug loaded nanoparticles, the initial burst was reduced which was comparatively higher in drug. Whereas, the formulation with 1mg/ml chitosan in 1.5mg/ml tripolyphosphate solution showed steady release over the entire period of drug release. Then this data was further validated through mathematical modelling to establish the mechanism of drug release kinetics, which showed a typical linear diffusion profile in optimised ETP loaded nanoparticles. <p class="card-text"><strong>Keywords:</strong> <a href="https://publications.waset.org/abstracts/search?q=ionic%20gelation" title="ionic gelation">ionic gelation</a>, <a href="https://publications.waset.org/abstracts/search?q=mucoadhesive%20nanoparticle" title=" mucoadhesive nanoparticle"> mucoadhesive nanoparticle</a>, <a href="https://publications.waset.org/abstracts/search?q=semi-permeable%20dialysis%20membrane" title=" semi-permeable dialysis membrane"> semi-permeable dialysis membrane</a>, <a href="https://publications.waset.org/abstracts/search?q=zeta%20potential" title=" zeta potential"> zeta potential</a> </p> <a href="https://publications.waset.org/abstracts/16460/comparative-analysis-of-in-vitro-release-profile-for-escitalopram-and-escitalopram-loaded-nanoparticles" class="btn btn-primary btn-sm">Procedia</a> <a href="https://publications.waset.org/abstracts/16460.pdf" target="_blank" class="btn btn-primary btn-sm">PDF</a> <span class="bg-info text-light px-1 py-1 float-right rounded"> Downloads <span class="badge badge-light">294</span> </span> </div> </div> <ul class="pagination"> <li class="page-item disabled"><span class="page-link">&lsaquo;</span></li> <li class="page-item active"><span class="page-link">1</span></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=release%20kinetics&page=2">2</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=release%20kinetics&page=3">3</a></li> <li class="page-item"><a class="page-link" href="https://publications.waset.org/abstracts/search?q=release%20kinetics&page=4">4</a></li> <li class="page-item"><a class="page-link" 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