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<!doctype html> <html lang="fr"> <head> <title>A Multiscale Haemorheological Computer-Based Model of Athero | 24076</title> <meta name="keywords" content="Glaucia C Pereira , "/> <meta name="description" content="The mortality caused by cardiovascular diseases is dramatically increasing [1-4]. Atherosclerosis is among the main contributors to this extremely high car..24076"/> <meta name="citation_publisher" content="Longdom Publishing SL" /> <meta name="citation_journal_title" content="Journal du g茅nie biom茅dical et des dispositifs m茅dicaux"> <meta name="citation_title" content="A Multiscale Haemorheological Computer-Based Model of Atherosclerosis: An In-Depth Investigation of Erythrocytes-Driven Flow Characteristics in Atheroma Development "> <meta name="citation_author" content="Glaucia C Pereira" /> <meta name="citation_year" content=""> <meta name="citation_volume" content="1"> <meta name="citation_issue" content="3"> <meta name="citation_abstract" content="The mortality caused by cardiovascular diseases is dramatically increasing [1-4]. Atherosclerosis is among the main contributors to this extremely high cardiovascular disease mortality [1]. Atherosclerosis is controlled by mechanical forces exerted by the flow of blood on the inner lining of arteries, the endothelium [5-9]. In order to fight this lethal disease a realistic computational model is required that offers an accurate understanding of the effect of blood flow on the arterial wall. In order to realistically describe complex blood flow patterns and their interaction with the arterial wall, we have developed an integrated computational technique that takes into account both the particulate cellular composition of the blood and the interactions between the particulate blood and the vessel wall, in macro-circulation. The cellular composition of the blood was modelled using a multiphase fluid dynamics method by computing both an Eulerian fluid domain for modelling blood plasma, and a Lagrangian solid domain that represented the blood cells. Interactions of the blood with the vessel wall were realistically modelled using a novel iterative immersed boundary method. Both the multiphase technique and the immersed boundary method were validated by comparing obtained numerical results with the literature [10-1], and a high degree of similarity was found. Moreover, our multiscale integrated model was applied to characterize clinically relevant flow patterns from atherosclerotic arterial segments. Our model revealed that under realistic non- Newtonian multiphase cellcontaining blood flow conditions, the pressure at the stenosis site is c. 30% higher than predicted by single-phase Newtonian fluid dynamics models [10,12]. This effect is most probably explained by a decrease of c. 28% in the peak velocity. The latest seems to be caused by the momentum interchange due to the collision of the particles (blood cells) with each other, with the vessel wall, and with the fluid phase (plasma). The most significant difference in velocities between the single-phase and the two-phase results was registered at the stenosis site. It was also found that high blood cell content (peak particle concentration) correlates with increasing flow laminarization. This means a decrease in velocity, which is more evidenced at the site of the stenosis. Additionally, our findings indicated that wakes forming downstream of the stenosis might be much weaker in non-Newtonian blood flow simulations compared to the Newtonian models. Taken together, our mathematical model and the resulting computational results might offer a more accurate understanding of the effects of realistic blood flow patterns on atherosclerotic vessels. This is of crucial importance since this deadly disease is initiated and progressed by blood flow related mechanical factors, such as the wall shear stress [8-9,22-25]. 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Atherosclerosis is among the main contributors to this extremely high cardiovascular disease mortality [1]. Atherosclerosis is controlled by mechanical forces exerted by the flow of blood on the inner lining of arteries, the endothelium [5-9]. In order to fight this lethal disease a realistic computational model is required that offers an accurate understanding of the effect of blood flow on the arterial wall. In order to realistically describe complex blood flow patterns and their interaction with the arterial wall, we have developed an integrated computational technique that takes into account both the particulate cellular composition of the blood and the interactions between the particulate blood and the vessel wall, in macro-circulation. The cellular composition of the blood was modelled using a multiphase fluid dynamics method by computing both an Eulerian fluid domain for modelling blood plasma, and a Lagrangian solid domain that represented the blood cells. Interactions of the blood with the vessel wall were realistically modelled using a novel iterative immersed boundary method. Both the multiphase technique and the immersed boundary method were validated by comparing obtained numerical results with the literature [10-1], and a high degree of similarity was found. Moreover, our multiscale integrated model was applied to characterize clinically relevant flow patterns from atherosclerotic arterial segments. Our model revealed that under realistic non- Newtonian multiphase cellcontaining blood flow conditions, the pressure at the stenosis site is c. 30% higher than predicted by single-phase Newtonian fluid dynamics models [10,12]. This effect is most probably explained by a decrease of c. 28% in the peak velocity. The latest seems to be caused by the momentum interchange due to the collision of the particles (blood cells) with each other, with the vessel wall, and with the fluid phase (plasma). The most significant difference in velocities between the single-phase and the two-phase results was registered at the stenosis site. It was also found that high blood cell content (peak particle concentration) correlates with increasing flow laminarization. This means a decrease in velocity, which is more evidenced at the site of the stenosis. Additionally, our findings indicated that wakes forming downstream of the stenosis might be much weaker in non-Newtonian blood flow simulations compared to the Newtonian models. Taken together, our mathematical model and the resulting computational results might offer a more accurate understanding of the effects of realistic blood flow patterns on atherosclerotic vessels. This is of crucial importance since this deadly disease is initiated and progressed by blood flow related mechanical factors, such as the wall shear stress [8-9,22-25].</p> <div class="alert alert-info text-left"><b>Clause de non-responsabilit茅:</b> Ce r茅sum茅 a 茅t茅 traduit 脿 l'aide d'outils d'intelligence artificielle et n'a pas encore 茅t茅 r茅vis茅 ou v茅rifi茅.</div> <div class="nav social-icons"> <a class="nav-link w-auto">Partagez cet article</a> <a title="Cliquez ici" target="_blank" href="https://www.facebook.com/sharer.php?u=https://french.longdom.org/abstract/a-multiscale-haemorheological-computerbased-model-of-atherosclerosis-an-indepth-investigation-of-erythrocytesdriven-flow-24076.html" rel="noopener"><i class="fab fa-facebook-f"></i></a> <a class="nav-link" title="Cliquez ici" target="_blank" href="https://twitter.com/share?url=https://french.longdom.org/abstract/a-multiscale-haemorheological-computerbased-model-of-atherosclerosis-an-indepth-investigation-of-erythrocytesdriven-flow-24076.html" rel="noopener"><i class="fab fa-twitter"></i></a> <a class="nav-link" title="Cliquez ici" target="_blank" href="https://www.linkedin.com/shareArticle?mini=true&url=https://french.longdom.org/abstract/a-multiscale-haemorheological-computerbased-model-of-atherosclerosis-an-indepth-investigation-of-erythrocytesdriven-flow-24076.html" rel="noopener"><i class="fab fa-linkedin-in"></i></a> <a class="nav-link" title="Cliquez ici" target="_blank" href="https://plus.google.com/share?url=https://french.longdom.org/abstract/a-multiscale-haemorheological-computerbased-model-of-atherosclerosis-an-indepth-investigation-of-erythrocytesdriven-flow-24076.html" rel="noopener"><i class="fab fa-google-plus-g"></i></a> </div> </div> </div> </div> </section> <footer class="bg-blue-grey-900 py-3"> <div class="container"> <div class="row"> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Liens de contenu</h4> <ul class="list-unstyled footer-links font-size-3"> <li><a class="" href="https://french.longdom.org/privacy-policy.html" title="Cliquez ici">politique de confidentialit茅</a></li> <li><a class="" href="https://french.longdom.org/terms-conditions.html" title="Cliquez ici">termes et conditions</a></li> <li><a class="" href="https://french.longdom.org/authors-reviewers-editors.html" title="Cliquez ici">Auteurs, critiques et 茅diteur</a></li> </ul> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Contacter Longdom</h4> <p><strong>Groupe Longdom SA</strong><br /> Avenue Roger Vandendriessche,<br /> 18, 1150 Bruxelles, Belgique<br /> T茅l茅phone : +442038085340<br /> <strong>Courriel :</strong> <a class="white" href="mailto:info@longdom.org" title="Cliquez ici">info@longdom.org</a></p> </div> <div class="col-12 col-sm-4"> <h4 class="white font-size-4 fweight-400 border-bottom-1 pb-2">Connecter</h4> <nav class="nav nav-pills social-icons-footer flex-column a-pl-0"> <a href="https://www.facebook.com/longdompublisher" title="Cliquez ici" target="_blank" class="nav-link bg-facebook-hover"><i class="fab fa-facebook-f bg-facebook"></i></a> <a href="https://www.linkedin.com/company/longdom-publishing-sl/" title="Cliquez ici" target="_blank" class="nav-link bg-linkedin-hover"><i class="fab fa-linkedin-in bg-linkedin"></i></a> <a href="https://twitter.com/LongdomP" title="Cliquez ici" target="_blank" class="nav-link bg-twitter-hover"><i class="fab fa-twitter bg-twitter"></i></a> <a href="https://www.instagram.com/longdom_publisher/" title="Cliquez ici" target="_blank" class="nav-link bg-instagram-hover"><i class="fab fa-instagram bg-instagram"></i></a> </nav> </div> </div> <div class="row text-center"> <div class="col"> <p>droits d auteur © 2025 <a href="https://french.longdom.org/" title="Cliquez ici" class="white">Longdom 脡ditions SL</a>.</p> </div> </div> </div> </footer>  <a href="#0" class="cd-top js-cd-top">Top</a>   <script src="https://code.jquery.com/jquery-3.3.1.min.js"></script> <script src="https://cdnjs.cloudflare.com/ajax/libs/popper.js/1.14.7/umd/popper.min.js"></script> <script src="https://stackpath.bootstrapcdn.com/bootstrap/4.3.1/js/bootstrap.min.js"></script>  <script> jQuery(function($) { $(window).scroll(function fix_element() { $('#target').css( $(window).scrollTop() > 100 ? 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