Day One | Covalent Drug Discovery & Development Summit

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class="fl-post-content clearfix" itemprop="text"> <div class="fl-builder-content fl-builder-content-595 fl-builder-content-primary fl-builder-global-templates-locked" data-post-id="595"><div class="fl-row fl-row-full-width fl-row-bg-photo fl-node-ck6jelrazov4 fl-row-default-height fl-row-align-center" data-node="ck6jelrazov4"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-full-width fl-node-content"> <div class="fl-col-group fl-node-quihwrvcop8b fl-col-group-equal-height fl-col-group-align-bottom" data-node="quihwrvcop8b"> <div class="fl-col fl-node-ad38col2x5ts fl-col-bg-color" data-node="ad38col2x5ts"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-heading fl-node-4zcqlryoi2es fl-animation fl-fade-up" data-node="4zcqlryoi2es" data-animation-delay="0" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <h2 class="fl-heading"> <span class="fl-heading-text">CONFERENCE DAY ONE</span> </h2> </div> </div> <div class="fl-module fl-module-rich-text fl-node-sd1c6ywtqxih fl-animation fl-fade-up" data-node="sd1c6ywtqxih" data-animation-delay="0.2" data-animation-duration="1"> <div class="fl-module-content fl-node-content"> <div class="fl-rich-text"> <p><strong>Wednesday, December 11, 2024</strong></p> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-fixed-width fl-row-bg-none fl-node-u3yzkm6ofdrx fl-row-default-height fl-row-align-center" data-node="u3yzkm6ofdrx"> <div class="fl-row-content-wrap"> <div class="fl-row-content fl-row-fixed-width fl-node-content"> <div class="fl-col-group fl-node-6wibvpc5dont" data-node="6wibvpc5dont"> <div class="fl-col fl-node-d8e01yhw49ni fl-col-bg-color" data-node="d8e01yhw49ni"> <div class="fl-col-content fl-node-content"><div class="fl-module fl-module-ee-agenda fl-node-v4h3b2p78ny6" data-node="v4h3b2p78ny6"> <div class="fl-module-content fl-node-content"> <div class="content"> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:00 am </span> <span style="color: #BB4E95;">Check-In & Light Breakfast</span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 8:50 am </span> Chair’s Opening Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23878" class="view-speaker" speaker-id="23878"><span>Ivan Cornella</span></a></em> Chief Scientific Officer, Covant Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Streamlining Hit Generation with High-Throughput & Unbiased Covalent Screens to Define Innovative Warheads for Hard-to-Drug Targets</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:00 am </span> Covalency Offers Unique Opportunities for Difficult Targets </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23879" class="view-speaker" speaker-id="23879"><span>Lynn McGregor</span></a></em> scientist, Novartis AG </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Covalency provides opportunities for difficult drug targets</li> <li>Screening identifies a starting point for a TF target</li> <li>Proteomics is an essential tool for covalency focused efforts </li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 9:30 am </span> Mass Spectrometry Screening & Hit Optimization Strategies for Efficient Covalent Drug Discovery </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23880" class="view-speaker" speaker-id="23880"><span>Brett Babin</span></a></em> Principal Scientist, Genentech </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Maximizing throughput for MS-based covalent screens</li> <li>Integrating data generated from MS screens to identify potent and selective hit compounds</li> <li>Triaging hits to identify the most tractable compounds</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:00 am </span> <span style="color: #BB4E95;">Panel Discussion:</span> Debating Systematic & Scalable Screening Methods to Rationally Discover & Develop Covalent Handles with Optimized Reactivity & Selectivity </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23881" class="view-speaker" speaker-id="23881"><span>Maurizio Pellecchia</span></a></em> Professor, University of California Riverside & Armida Labs </li> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23880" class="view-speaker" speaker-id="23880"><span>Brett Babin</span></a></em> Principal Scientist, Genentech </li> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23878" class="view-speaker" speaker-id="23878"><span>Ivan Cornella</span></a></em> Chief Scientific Officer, Covant Therapeutics </li> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23885" class="view-speaker" speaker-id="23885"><span>Monica Schenone</span></a></em> Head of Chemical Biology, Pfizer </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>What are the best methods for finding tractable hits? </li> <li>How can we streamline hit-to-lead optimizations?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 10:30 am </span> DNA-Encoded Library Technology- A Catalyst for Covalent Ligand Discovery </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24481" class="view-speaker" speaker-id="24481"><span>Paige Dickson</span></a></em> Principal Scientist - Research, X-Chem Pharmaceuticals </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>DNA-encoded libraries are massively diverse collections of drug-like molecules which afford a facile opportunity to identify ligands for small molecule drug discovery and development. We will review applications of these libraries to successfully identify novel chemical equity to protein targets, including KRas G12C and BTK </li> <li>X-Chem’s covalent DNA-Encoded Library (DEL) collection integrates learnings from FDA-approved covalent drugs, coupled with optimized covalent screening workflows, to support <em>de novo</em> hit discovery for challenging drug targets. Covalent DELs incorporate diverse warhead elements of varying reactivities and preferred amino acid engagement, providing a truly unbiased collection of ligands for early-stage covalent hit identification. </li> <li>Data-rich DEL outputs power computational strategies to maximize SAR information and propel hit candidates into actionable drug leads</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 11:00 am </span> <span style="color: #BB4E95;">Morning Break & Speed Networking</span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <p><span style="color: rgb(187, 78, 149);">Our speed networking session is the ideal opportunity to get face-to-face time with many of the brightest minds working to discover and develop covalent modalities. Introduce yourself to the attendees that you would like to have more in-depth conversations with, benchmark against industry leaders, and establish meaningful business relationships that you can pursue for the rest of the conference and beyond</span></p> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Accelerating the Development of Unbiased & Scalable Platforms to Access & De-Risk Novel Chemistry Amenable for Covalency & Propel Discovery Pipelines</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:00 pm </span> Practical Approaches to Accelerate Covalent Drug Discovery </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23886" class="view-speaker" speaker-id="23886"><span>Brent Martin</span></a></em> Senior Director, Chemical Biology, Odyssey Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Exploring early profiling and selection of actionable targets</li> <li>Assessing hits to predict target traceability</li> <li>Enabling biochemical and chemoproteomics assays to build programs</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 12:30 pm </span> Mechanistic Study of Reversible & Irreversible Covalent Inhibitors </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23887" class="view-speaker" speaker-id="23887"><span>Xiang yi</span></a></em> Senior Principal Scientist, Amgen Inc. </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>The emergence of reversible covalency addresses off-target safety concerns, countering challenges posed by irreversible covalent inhibitors. Yet, characterization of this novel mechanism is hindered by limited assays and tools</li> <li>Establishing enzyme kinetic assays, incorporating slow binding Ki Kinact measurement and jump dilution to enable the determination and differentiation of reversible from irreversible covalency mechanism</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:00 pm </span> Unveiling WuXi AppTec’s Innovative Approaches in the Identification of Covalent Small Molecule Binders </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker24485" class="view-speaker" speaker-id="24485"><span>Zhifeng Yu</span></a></em> Director - Functional Assay & Screening, WuXi AppTec </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li><span style="font-family: Helvetica, sans-serif; font-size: 10.5pt;">Innovative approaches for covalent hit finding</span></li> <li><span style="font-family: Helvetica, sans-serif; font-size: 10.5pt;">Integrated downstream validation methods</span></li> <li><span style="font-family: Helvetica, sans-serif; font-size: 10.5pt;">WuXi AppTec offers comprehensive target-to-lead services</span></li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 1:30 pm </span> <span style="color: #BB4E95;">Lunch Break & Networking </span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Spearheading the Specific Covalent Targeting of More Abundant Residues Beyond Cysteine to Access Novel Binding Pockets & Expand the Druggable Proteome </span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 2:30 pm </span> Specific Covalent Targeting of Histidine, Tyrosine & Lysine to Expand the Druggable Proteome </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23961" class="view-speaker" speaker-id="23961"><span>Andrea Zuhl</span></a></em> Head Chem Bio, HYKU Biosciences </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Development of novel warheads for covalent screening of histidine, tyrosine and lysine residues</li> <li>Enhancing the capture and mass spectrometry detection of sensitive peptide-ligand pairs</li> <li>Integration of structural information to prioritize novel binding pockets for further development of covalent or non-covalent compounds</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:00 pm </span> Targeting of Histidine Residues to Increase the Pool of Potential Targets Amendable for Covalent Drug Discovery </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23881" class="view-speaker" speaker-id="23881"><span>Maurizio Pellecchia</span></a></em> Professor, University of California Riverside & Armida Labs </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Showcasing how to identify and map histidine residues across a wide range of proteins to determine their potential as covalent drug targets</li> <li>How to marry the right electrophiles with histidine moieties</li> <li>Ligand-first versus electrophile-first approaches to target Histidine residues </li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 3:30 pm </span> <span style="color: #BB4E95;">Afternoon Networking Break</span> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> </span> <center><span style="color: #0E4B8C;">Advancing Chemoproteomic Platforms & Probes to Better Interrogate Novel Biology & Amplify the Druggable Proteome Outside Oncology</span></center> </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:00 pm </span> Towards a Chemical Biology Platform for the Systematic Discovery & Evaluation of Novel Covalent Chemistry </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23971" class="view-speaker" speaker-id="23971"><span>Sebastian Essig</span></a></em> Director & Group Leader - Chemical Biology & Life Science Technology Department, Bayer </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Exploring insights into flexible library setup to synthesis novel covalent warhead libraries</li> <li>Showcasing MS and proteomics-based discovery and profiling assays for novel covalent warhead motifs</li> <li>Examining setups to screen and profile novel covalent libraries</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 4:30 pm </span> <span style="color: #BB4E95;">Roundtable Discussion:</span> Fueling the Covalency Renaissance by Strategizing the Chemistry Toolbox to Target Residues Beyond Cysteine with Orthogonal Reactivity </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23879" class="view-speaker" speaker-id="23879"><span>Lynn McGregor</span></a></em> scientist, Novartis AG </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>Which amino acids are seen as the next frontier in covalent drug discovery? </li> <li>What is the mass spectrometry or alternative screening toolbox for other amino acids?</li> <li>How can we build drug-like warheads that hit other side chains? Should we be screening these more promiscuous warheads?</li> <li>What pre-clinical safety and ADME data would give you confidence to use these chemotypes in your own projects?</li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:00 pm </span> Covalent Fragment-Based Ligand Discovery to Drug Refractory Targets </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23977" class="view-speaker" speaker-id="23977"><span>Rhamy Zeid</span></a></em> Vice President, Head of Biology, Nexo Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> <h3 class="eehw-agenda-synopsis"> Synopsis </h3> <ul> <li>How can covalent fragment-based ligand discovery be leveraged to tackle so-called undruggable targets?</li> <li>What are the advantages of a target-centric approach to covalent fragment-based ligand discovery?</li> <li>What approaches (biochemical and cell-based) can be deployed to progress covalent fragment starting points to mature lead molecules within a drug discovery campaign? </li> </ul> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:30 pm </span> Chairs Closing Remarks </h3>  <ul class="non-expand-speaker-list"> <li> <em><a href="https://covalent-drug-discovery.com/speakers/#speaker23878" class="view-speaker" speaker-id="23878"><span>Ivan Cornella</span></a></em> Chief Scientific Officer, Covant Therapeutics </li> </ul>  <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> <div class="inner-agenda" style="background: "> <h3> <span class="time"> 5:35 pm </span> End of Conference Day One </h3>   <div class="clearfix"></div>  <div class="agenda-content"> </div>  </div> </div> </div> </div> </div> </div> </div> </div> </div> </div> <div class="fl-row fl-row-full-width fl-row-bg-none fl-node-5bb333c7ecf02 fl-row-default-height fl-row-align-center" data-node="5bb333c7ecf02"> <div 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node.waypoint({offset:offset,handler:FLBuilderLayout._doModuleAnimation});});}},_doModuleAnimation:function(){var module='undefined'==typeof this.element?$(this):$(this.element),delay=parseFloat(module.data('animation-delay')),duration=parseFloat(module.data('animation-duration'));if(!isNaN(duration)){module.css('animation-duration',duration+'s');} if(!isNaN(delay)&&delay>0){setTimeout(function(){module.addClass('fl-animated');},delay*1000);}else{setTimeout(function(){module.addClass('fl-animated');},1);}},_initHash:function(){var hash=window.location.hash.replace('#','').split('/').shift(),element=null,tabs=null,responsiveLabel=null,tabIndex=null,label=null;if(''!==hash){try{element=$('#'+hash);if(element.length>0){if(element.hasClass('fl-accordion-item')){setTimeout(function(){element.find('.fl-accordion-button').trigger('click');},100);} 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.fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){$(function(){$('.fl-map').on('click',function(){$(this).find('iframe').css('pointer-events','auto');});});})(jQuery);;jQuery(function($){$(function(){$('.fl-node-zd4retia01xj .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;jQuery(function($){$(function(){$('.fl-node-5ba1fe150af26 .fl-photo-img').on('mouseenter',function(e){$(this).data('title',$(this).attr('title')).removeAttr('title');}).on('mouseleave',function(e){$(this).attr('title',$(this).data('title')).data('title',null);});});window._fl_string_to_slug_regex='a-zA-Z0-9';});;(function($){FLBuilderMenu=function(settings){this.nodeId=settings.id;this.nodeClass='.fl-node-'+settings.id;this.wrapperClass=this.nodeClass+' .fl-menu';this.type=settings.type;this.mobileToggle=settings.mobile;this.mobileBelowRow=settings.mobileBelowRow;this.mobileFlyout=settings.mobileFlyout;this.breakPoints=settings.breakPoints;this.mobileBreakpoint=settings.mobileBreakpoint;this.currentBrowserWidth=$(window).width();this.postId=settings.postId;this.mobileStacked=settings.mobileStacked;this._initMenu();$(window).on('resize',$.proxy(function(e){var width=$(window).width();if(width!=this.currentBrowserWidth){this.currentBrowserWidth=width;this._initMenu();this._clickOrHover();} this._resizeFlyoutMenuPanel();},this));$(window).on('scroll',$.proxy(function(e){this._resizeFlyoutMenuPanel();},this));$('body').on('click',$.proxy(function(e){if('undefined'!==typeof FLBuilderConfig){return;} var activeMobileMenu=$(this.wrapperClass+' .fl-menu-mobile-toggle.fl-active');if(activeMobileMenu.length&&('expanded'!==this.mobileToggle)){$(activeMobileMenu).trigger('click');} $(this.wrapperClass).find('.fl-has-submenu').removeClass('focus');$(this.wrapperClass).find('.fl-has-submenu .sub-menu').removeClass('focus');},this));$(this.wrapperClass+' ul.menu > li:last-child').on('focusout',$.proxy(function(e){if($(this.wrapperClass).find('.fl-menu-mobile-toggle').hasClass('fl-active')&&('expanded'!==this.mobileToggle)){if(!$(e.relatedTarget).parent().hasClass('menu-item')){$(this.wrapperClass).find('.fl-menu-mobile-toggle').trigger('click');}}},this));};FLBuilderMenu.prototype={nodeClass:'',wrapperClass:'',type:'',breakPoints:{},$submenus:null,_isMobile:function(){return this.currentBrowserWidth<=this.breakPoints.small?true:false;},_isMedium:function(){return this.currentBrowserWidth<=this.breakPoints.medium?true:false;},_isLarge:function(){return this.currentBrowserWidth<=this.breakPoints.large?true:false;},_isMenuToggle:function(){if(('always'==this.mobileBreakpoint||(this._isMobile()&&'mobile'==this.mobileBreakpoint)||(this._isMedium()&&'medium-mobile'==this.mobileBreakpoint)||(this._isLarge()&&'large-mobile'==this.mobileBreakpoint))&&($(this.wrapperClass).find('.fl-menu-mobile-toggle').is(':visible')||'expanded'==this.mobileToggle)){return true;} return false;},_initMenu:function(){this._setupSubmenu();this._menuOnFocus();this._menuOnEscape();this._submenuOnClick();if($(this.nodeClass).length&&this.type=='horizontal'){this._initMegaMenus();} if(this._isMenuToggle()||this.type=='accordion'){$(this.wrapperClass).off('mouseenter mouseleave');this._menuOnClick();this._clickOrHover();}else{$(this.wrapperClass).off('click');this._submenuOnRight();this._submenuRowZindexFix();} if(this.mobileToggle!='expanded'){this._toggleForMobile();} if($(this.wrapperClass).find('.fl-menu-search-item').length){this._toggleMenuSearch();} if($(this.wrapperClass).find('.fl-menu-cart-item').length){this._wooUpdateParams();}},_setupSubmenu:function(){$(this.wrapperClass+' ul.sub-menu').each(function(){$(this).closest('li').attr('aria-haspopup','true');});},_menuOnFocus:function(){var cKey=0,isShifted=false;$(this.nodeClass).off('keydown').on('keydown','a',function(e){cKey=e.which;isShifted=e.shiftKey;});$(this.nodeClass).off('focus').on('focus','a',$.proxy(function(e){var $menuItem=$(e.target).parents('.menu-item').first(),$parents=$(e.target).parentsUntil(this.wrapperClass);$('.fl-menu .focus').removeClass('focus');$parents.addClass('focus') if(!$menuItem.closest('.fl-has-submenu').hasClass('escaped')){$menuItem.addClass('focus')} else{$menuItem.closest('.fl-has-submenu').removeClass('focus escaped')}},this)).on('focusout','a',$.proxy(function(e){var el=$(e.target).parent(),$megaMenu=el.closest('.mega-menu'),$megaLastItem=$megaMenu.find('> .sub-menu > .menu-item:last-child'),$lastItem=el.parents('.fl-has-submenu:last').find('.menu-item:last'),isLastChild=!$megaMenu.length&&el.is($lastItem);if($megaMenu.length){isLastChild=el.is($megaLastItem)||el.is($megaLastItem.find('.menu-item:last-child'));} if(isLastChild&&cKey===9&&isShifted){isLastChild=false;cKey=0;isShifted=false;} else if(cKey===27){isLastChild=false;} if(isLastChild){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_menuOnEscape:function(){$('body').off('keydown').on('keydown',$.proxy(function(e){if(e.which!==27){return;} if($(e.target).closest('.menu-item').length){var activeSubmenu=null,menuItem=$(e.target).closest('.menu-item'),type=menuItem.closest('.fl-menu-accordion').length?'accordion':'horizontal';if('horizontal'===type){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('focus')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.parent().addClass('escaped');activeSubmenu.parent().find('a:first').focus();} else{if(menuItem.hasClass('fl-has-submenu')&&'accordion'===type&&menuItem.hasClass('fl-active')){activeSubmenu=menuItem.find('> ul.sub-menu');} else{activeSubmenu=menuItem.closest('ul.sub-menu');} activeSubmenu.slideUp(400,function(){if(menuItem.hasClass('fl-has-submenu')&&menuItem.hasClass('fl-active')){activeSubmenu.parent().last().find('a:first').focus();} else{menuItem.removeClass('focus');menuItem.parents('.menu-item').first().find('a:first').focus();} activeSubmenu.parent().last().removeClass('fl-active');});}} else{$('.fl-menu').find('li.menu-item.focus').last().removeClass('focus');}},this));},_menuOnClick:function(){$(this.wrapperClass).off().on('click','.fl-has-submenu-container',$.proxy(function(e){var $link=$(e.target).parents('.fl-has-submenu').first(),$subMenu=$link.children('.sub-menu').first(),$href=$link.children('.fl-has-submenu-container').first().find('> a').attr('href'),$subMenuParents=$(e.target).parents('.sub-menu'),$activeParents=$(e.target).parents('.fl-has-submenu.fl-active');if(!$subMenu.is(':visible')||$(e.target).hasClass('fl-menu-toggle')||($subMenu.is(':visible')&&(typeof $href==='undefined'||$href=='#'))){e.preventDefault();} else{e.stopPropagation();window.location.href=$href;return;} if($(this.wrapperClass).hasClass('fl-menu-accordion-collapse')){if(!$link.parents('.menu-item').hasClass('fl-active')){$('.menu .fl-active',this.wrapperClass).not($link).removeClass('fl-active');} else if($link.parents('.menu-item').hasClass('fl-active')&&$link.parent('.sub-menu').length){$('.menu .fl-active',this.wrapperClass).not($link).not($activeParents).removeClass('fl-active');} $('.sub-menu',this.wrapperClass).not($subMenu).not($subMenuParents).slideUp('normal');} if(!this.mobileStacked&&'horizontal'==this.type&&'expanded'==this.mobileToggle){$(this.wrapperClass).find('.fl-active').not($link).not($activeParents).removeClass('fl-active');} else{$subMenu.slideToggle();} $link.toggleClass('fl-active');e.stopPropagation();},this));},_submenuOnClick:function(){$(this.wrapperClass+' .sub-menu').off().on('click','a',$.proxy(function(e){if($(e.target).parent().hasClass('focus')){$(e.target).parentsUntil(this.wrapperClass).removeClass('focus');}},this));},_clickOrHover:function(){this.$submenus=this.$submenus||$(this.wrapperClass).find('.sub-menu');var $wrapper=$(this.wrapperClass),$menu=$wrapper.find('.menu');$li=$wrapper.find('.fl-has-submenu');if(this._isMenuToggle()){$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').fadeOut();}});}else{$li.each(function(el){if(!$(this).hasClass('fl-active')){$(this).find('.sub-menu').css({'display':'','opacity':''});}});}},_submenuOnRight:function(){$(this.wrapperClass).on('mouseenter focus','.fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} var $link=$(e.currentTarget),$parent=$link.parent(),$subMenu=$link.find('.sub-menu'),subMenuWidth=$subMenu.width(),subMenuPos=0,bodyWidth=$('body').width();if($link.closest('.fl-menu-submenu-right').length!==0){$link.addClass('fl-menu-submenu-right');}else if($('body').hasClass('rtl')){subMenuPos=$parent.is('.sub-menu')?$parent.offset().left-subMenuWidth:$link.offset().left-$link.width()-subMenuWidth;if(subMenuPos<=0){$link.addClass('fl-menu-submenu-right');}}else{subMenuPos=$parent.is('.sub-menu')?$parent.offset().left+$parent.width()+subMenuWidth:$link.offset().left+$link.width()+subMenuWidth;if(subMenuPos>bodyWidth){$link.addClass('fl-menu-submenu-right');}}},this)).on('mouseleave','.fl-has-submenu',$.proxy(function(e){$(e.currentTarget).removeClass('fl-menu-submenu-right');},this));},_submenuRowZindexFix:function(e){$(this.wrapperClass).on('mouseenter','ul.menu > .fl-has-submenu',$.proxy(function(e){if($(e.currentTarget).find('.sub-menu').length===0){return;} $(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','10');},this)).on('mouseleave','ul.menu > .fl-has-submenu',$.proxy(function(e){$(this.nodeClass).closest('.fl-row').find('.fl-row-content').css('z-index','');},this));},_toggleForMobile:function(){var $wrapper=null,$menu=null,self=this;if(this._isMenuToggle()){if(this._isMobileBelowRowEnabled()){this._placeMobileMenuBelowRow();$wrapper=$(this.wrapperClass);$menu=$(this.nodeClass+'-clone');$menu.find('ul.menu').show();} else{$wrapper=$(this.wrapperClass);$menu=$wrapper.find('.menu');} if(!$wrapper.find('.fl-menu-mobile-toggle').hasClass('fl-active')&&!self.mobileFlyout){$menu.css({display:'none'});} if(self.mobileFlyout){this._initFlyoutMenu();} $wrapper.on('click','.fl-menu-mobile-toggle',function(e){$(this).toggleClass('fl-active');if(self.mobileFlyout){self._toggleFlyoutMenu();} else{var targetMenu=null;if(self.mobileBelowRow){targetMenu=$(this).closest('.fl-col').next('.fl-menu-mobile-clone');}else{targetMenu=$(this).closest('.fl-menu').find('ul.menu');} if(targetMenu.length){$menu=$(targetMenu);} $menu.slideToggle();} e.stopPropagation();});$menu.off().on('click','.menu-item > a[href*="#"]:not([href="#"])',function(e){var $href=$(this).attr('href'),$targetID=$href.split('#')[1],element=$('#'+$targetID);if($('body').find(element).length>0){$(this).toggleClass('fl-active');FLBuilderLayout._scrollToElement(element);if(!self._isMenuToggle()){$menu.slideToggle();}}});} else{if(this._isMobileBelowRowEnabled()){this._removeMenuFromBelowRow();} $wrapper=$(this.wrapperClass),$menu=$wrapper.find('ul.menu');$wrapper.find('.fl-menu-mobile-toggle').removeClass('fl-active');$menu.css({display:''});if(!this._isMobileBelowRowEnabled()){$menu.off('click','.menu-item > a[href*="#"]:not([href="#"])');} if(this.mobileFlyout&&$wrapper.find('.fl-menu-mobile-flyout').length>0){$('body').css('margin','');$('.fl-builder-ui-pinned-content-transform').css('transform','');$menu.unwrap();$wrapper.find('.fl-menu-mobile-close').remove();$wrapper.find('.fl-menu-mobile-opacity').remove();}}},_initMegaMenus:function(){var module=$(this.nodeClass),rowContent=module.closest('.fl-row-content'),rowWidth=rowContent.width(),megas=module.find('.mega-menu'),disabled=module.find('.mega-menu-disabled'),isToggle=this._isMenuToggle();if(isToggle){megas.removeClass('mega-menu').addClass('mega-menu-disabled');module.find('li.mega-menu-disabled > ul.sub-menu').css('width','');rowContent.css('position','');}else{disabled.removeClass('mega-menu-disabled').addClass('mega-menu');module.find('li.mega-menu > ul.sub-menu').css('width',rowWidth+'px');rowContent.css('position','relative');}},_isMobileBelowRowEnabled:function(){return this.mobileBelowRow&&$(this.nodeClass).closest('.fl-col').length;},_placeMobileMenuBelowRow:function(){if($(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=null,col=module.closest('.fl-col');if(module.length<1){return;} clone=(module.length>1)?$(module[0]).clone():module.clone();module.find('ul.menu').remove();clone.addClass((this.nodeClass+'-clone').replace('.',''));clone.addClass('fl-menu-mobile-clone');clone.find('.fl-menu-mobile-toggle').remove();col.after(clone);if(module.hasClass('fl-animation')){clone.removeClass('fl-animation');} this._menuOnClick();},_removeMenuFromBelowRow:function(){if(!$(this.nodeClass+'-clone').length){return;} var module=$(this.nodeClass),clone=$(this.nodeClass+'-clone'),menu=clone.find('ul.menu');module.find('.fl-menu-mobile-toggle').after(menu);clone.remove();menu.find('a').each(FLBuilderLayout._initAnchorLink);},_initFlyoutMenu:function(){var win=$(window),wrapper=$(this.wrapperClass),menu=wrapper.find('ul.menu'),button=wrapper.find('.fl-menu-mobile-toggle');if(0===wrapper.find('.fl-menu-mobile-flyout').length){menu.wrap('<div class="fl-menu-mobile-flyout"></div>');} if(0===wrapper.find('.fl-menu-mobile-close').length){close=window.fl_responsive_close||'Close' wrapper.find('.fl-menu-mobile-flyout').prepend('<button class="fl-menu-mobile-close" aria-label="'+close+'"><i class="fas fa-times" aria-hidden="true"></i></button>');} if(wrapper.hasClass('fl-menu-responsive-flyout-push-opacity')&&0===wrapper.find('.fl-menu-mobile-opacity').length){wrapper.append('<div class="fl-menu-mobile-opacity"></div>');} wrapper.on('click','.fl-menu-mobile-opacity, .fl-menu-mobile-close',function(e){button.trigger('click');e.stopPropagation();});if('undefined'!==typeof FLBuilder){FLBuilder.addHook('restartEditingSession',function(){$('.fl-builder-ui-pinned-content-transform').css('transform','');if(button.hasClass('fl-active')){button.trigger('click');}});}},_toggleFlyoutMenu:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),position=wrapper.hasClass('fl-flyout-right')?'right':'left',pushMenu=wrapper.hasClass('fl-menu-responsive-flyout-push')||wrapper.hasClass('fl-menu-responsive-flyout-push-opacity'),opacity=wrapper.find('.fl-menu-mobile-opacity'),marginPos={},posAttr={},fixedPos={},winHeight=$(window).height(),fixedHeader=$('header, header > div');this._resizeFlyoutMenuPanel();if($('.fl-builder-ui-pinned-content-transform').length>0&&!$('body').hasClass('fl-builder-edit')){$('.fl-builder-ui-pinned-content-transform').css('transform','none');} if(pushMenu){marginPos['margin-'+position]=button.hasClass('fl-active')?'250px':'0px';$('body').animate(marginPos,200);if(fixedHeader.length>0){fixedPos[position]=button.hasClass('fl-active')?'250px':'0px';fixedHeader.each(function(){if('fixed'==$(this).css('position')){$(this).css({'-webkit-transition':'none','-o-transition':'none','transition':'none'});$(this).animate(fixedPos,200);}});}} if(opacity.length>0&&button.hasClass('fl-active')){opacity.show();} else{opacity.hide();}},_resizeFlyoutMenuPanel:function(){const wrapper=$(this.wrapperClass);const wrapFlyout=wrapper.find('.fl-menu-mobile-flyout');if(wrapFlyout.length>0){wrapFlyout.css(this._getFlyoutMenuPanelPosition());}},_getFlyoutMenuPanelPosition:function(){var wrapper=$(this.wrapperClass),button=wrapper.find('.fl-menu-mobile-toggle'),wrapFlyout=wrapper.find('.fl-menu-mobile-flyout'),side=wrapper.hasClass('fl-flyout-right')?'right':'left',winHeight=$(window).outerHeight(),winTop=$(window).scrollTop(),adminBarHeight=$('#wpadminbar').length?$('#wpadminbar').height():0,flyoutPosition={};flyoutPosition[side]='-267px';if(!button.hasClass('fl-active')){return flyoutPosition;} flyoutPosition[side]='0px';flyoutPosition['height']=winHeight+'px';flyoutPosition['top']='0px';if(adminBarHeight>0){const diff=adminBarHeight-winTop;flyoutPosition['top']=diff<=0?'0px':(diff)+'px';} return flyoutPosition;},_toggleMenuSearch:function(){var wrapper=$(this.wrapperClass).find('.fl-menu-search-item'),button=wrapper.find('a.fl-button'),form=wrapper.find('.fl-search-form-input-wrap'),self=this;button.on('click',function(e){e.preventDefault();if(form.is(':visible')){form.stop().fadeOut(200);} else{form.stop().fadeIn(200);$('body').on('click.fl-menu-search',$.proxy(self._hideMenuSearch,self));form.find('.fl-search-text').focus();}});},_hideMenuSearch:function(e){var form=$(this.wrapperClass).find('.fl-search-form-input-wrap');if(e!==undefined){if($(e.target).closest('.fl-menu-search-item').length>0){return;}} form.stop().fadeOut(200);$('body').off('click.fl-menu-search');},_wooUpdateParams:function(){if('undefined'!==typeof wc_cart_fragments_params){wc_cart_fragments_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;} if('undefined'!==typeof wc_add_to_cart_params){wc_add_to_cart_params.wc_ajax_url+='&fl-menu-node='+this.nodeId+'&post-id='+this.postId;}},};})(jQuery);;(function($){$(function(){new FLBuilderMenu({id:'5ba1fe150af69',type:'horizontal',mobile:'text',mobileBelowRow:true,mobileFlyout:false,breakPoints:{large:1200,medium:992,small:768},mobileBreakpoint:'medium-mobile',postId:'54',mobileStacked:true,});});})(jQuery);;(function($){FLThemeBuilderHeaderLayout={win:null,body:null,header:null,overlay:false,hasAdminBar:false,stickyOn:'',breakpointWidth:0,init:function(){var editing=$('html.fl-builder-edit').length,header=$('.fl-builder-content[data-type=header]'),menuModule=header.find('.fl-module-menu'),breakpoint=null;if(!editing&&header.length){header.imagesLoaded($.proxy(function(){this.win=$(window);this.body=$('body');this.header=header.eq(0);this.overlay=!!Number(header.attr('data-overlay'));this.hasAdminBar=!!$('body.admin-bar').length;this.stickyOn=this.header.data('sticky-on');breakpoint=this.header.data('sticky-breakpoint');if(''==this.stickyOn){if(typeof FLBuilderLayoutConfig.breakpoints[breakpoint]!==undefined){this.breakpointWidth=FLBuilderLayoutConfig.breakpoints[breakpoint];} else{this.breakpointWidth=FLBuilderLayoutConfig.breakpoints.medium;}} if(Number(header.attr('data-sticky'))){this.header.data('original-top',this.header.offset().top);this.win.on('resize',$.throttle(500,$.proxy(this._initSticky,this)));this._initSticky();}},this));}},_initSticky:function(e){var header=$('.fl-builder-content[data-type=header]'),windowSize=this.win.width(),makeSticky=false;makeSticky=this._makeWindowSticky(windowSize);if(makeSticky||(this.breakpointWidth>0&&windowSize>=this.breakpointWidth)){this.win.on('scroll.fl-theme-builder-header-sticky',$.proxy(this._doSticky,this));if(e&&'resize'===e.type){if(this.header.hasClass('fl-theme-builder-header-sticky')){this._doSticky(e);} this._adjustStickyHeaderWidth();} if(Number(header.attr('data-shrink'))){this.header.data('original-height',this.header.outerHeight());this.win.on('resize',$.throttle(500,$.proxy(this._initShrink,this)));this._initShrink();} this._initFlyoutMenuFix(e);}else{this.win.off('scroll.fl-theme-builder-header-sticky');this.win.off('resize.fl-theme-builder-header-sticky');this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');}},_makeWindowSticky:function(windowSize){var makeSticky=false;switch(this.stickyOn){case'xl':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['large'];break;case'':case'desktop':makeSticky=windowSize>=FLBuilderLayoutConfig.breakpoints['medium'];break;case'desktop-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small'];break;case'large':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['medium']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'large-medium':makeSticky=windowSize>FLBuilderLayoutConfig.breakpoints['small']&&windowSize<=FLBuilderLayoutConfig.breakpoints['large'];break;case'medium':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']&&windowSize>FLBuilderLayoutConfig.breakpoints['small']);break;case'medium-mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['medium']);break;case'mobile':makeSticky=(windowSize<=FLBuilderLayoutConfig.breakpoints['small']);break;case'all':makeSticky=true;break;} return makeSticky;},_doSticky:function(e){var winTop=Math.floor(this.win.scrollTop()),headerTop=Math.floor(this.header.data('original-top')),hasStickyClass=this.header.hasClass('fl-theme-builder-header-sticky'),hasScrolledClass=this.header.hasClass('fl-theme-builder-header-scrolled'),beforeHeader=this.header.prevAll('.fl-builder-content'),bodyTopPadding=parseInt(jQuery('body').css('padding-top')),winBarHeight=$('#wpadminbar').length?$('#wpadminbar').outerHeight():0,headerHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(this.hasAdminBar&&this.win.width()>600){winTop+=Math.floor(winBarHeight);} if(winTop>headerTop){if(!hasStickyClass){if(e&&('scroll'===e.type||'smartscroll'===e.type)){this.header.addClass('fl-theme-builder-header-sticky');if(this.overlay&&beforeHeader.length){this.header.css('top',winBarHeight);}} if(!this.overlay){this._adjustHeaderHeight();}}} else if(hasStickyClass){this.header.removeClass('fl-theme-builder-header-sticky');this.header.removeAttr('style');this.header.parent().css('padding-top','0');} this._adjustStickyHeaderWidth();if(winTop>headerTop){if(!hasScrolledClass){this.header.addClass('fl-theme-builder-header-scrolled');}}else if(hasScrolledClass){this.header.removeClass('fl-theme-builder-header-scrolled');} this._flyoutMenuFix(e);},_initFlyoutMenuFix:function(e){var header=this.header,menuModule=header.closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),isPushMenu=menuModule.hasClass('fl-menu-responsive-flyout-push')||menuModule.hasClass('fl-menu-responsive-flyout-push-opacity'),isOverlay=menuModule.hasClass('fl-menu-responsive-flyout-overlay'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',flyoutParent=header.parent().is('header')?header.parent().parent():header.parent();isFullWidth=this.win.width()===header.width(),flyoutLayout='',activePos=250,headerPos=0;if(!flyoutMenu.length){return;} if(this.win.width()>header.parent().width()){headerPos=(this.win.width()-header.width())/ 2;} if(isOverlay){activePos=headerPos;} else if(isPushMenu){activePos=activePos+headerPos;} flyoutMenu.data('activePos',activePos);if(isPushMenu){flyoutLayout='push-'+flyoutPos;} else if(isOverlay){flyoutLayout='overlay-'+flyoutPos;} if(isPushMenu&&!$('html').hasClass('fl-theme-builder-has-flyout-menu')){$('html').addClass('fl-theme-builder-has-flyout-menu');} if(!flyoutParent.hasClass('fl-theme-builder-flyout-menu-'+flyoutLayout)){flyoutParent.addClass('fl-theme-builder-flyout-menu-'+flyoutLayout);} if(!header.hasClass('fl-theme-builder-flyout-menu-overlay')&&isOverlay){header.addClass('fl-theme-builder-flyout-menu-overlay');} if(!header.hasClass('fl-theme-builder-header-full-width')&&isFullWidth){header.addClass('fl-theme-builder-header-full-width');} else if(!isFullWidth){header.removeClass('fl-theme-builder-header-full-width');} menuModule.on('click','.fl-menu-mobile-toggle',$.proxy(function(event){if(menuModule.find('.fl-menu-mobile-toggle.fl-active').length){$('html').addClass('fl-theme-builder-flyout-menu-active');event.stopImmediatePropagation();} else{$('html').removeClass('fl-theme-builder-flyout-menu-active');} this._flyoutMenuFix(event);},this));},_flyoutMenuFix:function(e){var header=this.header,menuModule=$(e.target).closest('.fl-menu'),flyoutMenu=menuModule.find('.fl-menu-mobile-flyout'),flyoutPos=menuModule.hasClass('fl-flyout-right')?'right':'left',menuOpacity=menuModule.find('.fl-menu-mobile-opacity'),isScroll='undefined'!==typeof e&&'scroll'===e.handleObj.type,activePos='undefined'!==typeof flyoutMenu.data('activePos')?flyoutMenu.data('activePos'):0,headerPos=(this.win.width()-header.width())/ 2,inactivePos=headerPos>0?activePos+4:254;if(!flyoutMenu.length){return;} if(this.overlay){return;} if($('.fl-theme-builder-flyout-menu-active').length){if(isScroll&&!flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.addClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-header-sticky')){if(!isScroll){setTimeout($.proxy(function(){flyoutMenu.css(flyoutPos,'-'+activePos+'px');},this),1);} else{flyoutMenu.css(flyoutPos,'-'+activePos+'px');}} else{flyoutMenu.css(flyoutPos,'0px');}} else{if(flyoutMenu.hasClass('fl-menu-disable-transition')){flyoutMenu.removeClass('fl-menu-disable-transition');} if(header.hasClass('fl-theme-builder-flyout-menu-overlay')&&headerPos>0&&headerPos<250){if(header.hasClass('fl-theme-builder-header-sticky')){inactivePos=headerPos+254;} else{inactivePos=254;}} if(e&&e.type==='resize'){inactivePos=headerPos+254;} flyoutMenu.css(flyoutPos,'-'+inactivePos+'px');} if(e&&menuModule.is('.fl-menu-responsive-flyout-overlay')&&$.infinitescroll){e.stopImmediatePropagation();} if(menuOpacity.length){if(header.hasClass('fl-theme-builder-header-sticky')){if('0px'===menuOpacity.css('left')){menuOpacity.css('left','-'+headerPos+'px');}} else{menuOpacity.css('left','');}}},_adjustStickyHeaderWidth:function(){if($('body').hasClass('fl-fixed-width')){var parentWidth=this.header.parent().width();if(this.win.width()>=992){this.header.css({'margin':'0 auto','max-width':parentWidth,});} else{this.header.css({'margin':'','max-width':'',});}}},_adjustHeaderHeight:function(){var beforeHeader=this.header.prevAll('.fl-builder-content'),beforeHeaderHeight=0,beforeHeaderFix=0,headerHeight=Math.floor(this.header.outerHeight()),bodyTopPadding=parseInt($('body').css('padding-top')),wpAdminBarHeight=0,totalHeaderHeight=0;if(isNaN(bodyTopPadding)){bodyTopPadding=0;} if(beforeHeader.length){$.each(beforeHeader,function(){beforeHeaderHeight+=Math.floor($(this).outerHeight());});beforeHeaderFix=2;} if(this.hasAdminBar&&this.win.width()<=600){wpAdminBarHeight=Math.floor($('#wpadminbar').outerHeight());} totalHeaderHeight=Math.floor(beforeHeaderHeight+headerHeight);if(headerHeight>0){var headerParent=this.header.parent(),headerParentTopPadding=0;if($(headerParent).is('body')){headerParentTopPadding=Math.floor(headerHeight-wpAdminBarHeight);}else{headerParentTopPadding=Math.floor(headerHeight-bodyTopPadding-wpAdminBarHeight);} $(headerParent).css('padding-top',(headerParentTopPadding-beforeHeaderFix)+'px');this.header.css({'-webkit-transform':'translate(0px, -'+totalHeaderHeight+'px)','-ms-transform':'translate(0px, -'+totalHeaderHeight+'px)','transform':'translate(0px, -'+totalHeaderHeight+'px)'});}},_initShrink:function(e){if(this.win.width()>=this.breakpointWidth){this.win.on('scroll.fl-theme-builder-header-shrink',$.proxy(this._doShrink,this));this._setImageMaxHeight();if(this.win.scrollTop()>0){this._doShrink();}}else{this.header.parent().css('padding-top','0');this.win.off('scroll.fl-theme-builder-header-shrink');this._removeShrink();this._removeImageMaxHeight();}},_doShrink:function(e){var winTop=this.win.scrollTop(),headerTop=this.header.data('original-top'),headerHeight=this.header.data('original-height'),shrinkImageHeight=this.header.data('shrink-image-height'),windowSize=this.win.width(),makeSticky=this._makeWindowSticky(windowSize),hasClass=this.header.hasClass('fl-theme-builder-header-shrink');if(this.hasAdminBar){winTop+=32;} if(makeSticky&&(winTop>headerTop+headerHeight)){if(!hasClass){this.header.addClass('fl-theme-builder-header-shrink');this.header.find('img').each(function(i){var 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Day One | Covalent Drug Discovery & Development Summit