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</div><div class="loc article-post-header"><div id="post-header-social-block_1-0" class="comp post-header-social-block mntl-block"><div id="social-share-block_1-0" class="comp social-share-block mntl-block"><ul id="social-share_1-0" class="comp social-share mntl-social-share share" data-title="Stem Cells" document="ListStructuredContentDocumentEx{parent=BaseDocumentEx{templateType=LISTSC, documentId=373346, bestTitle='Stem Cells'}}" data-description="Stem cells are unique cells of the body in that they are unspecialized and have the ability to develop into several different types of cells." data-tracking-container="true"> <li class="share-item share-item-facebook"> <span data-href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.thoughtco.com%2Funderstanding-stem-cells-373346%3Futm_source%3Dfacebook.com%26utm_medium%3Dsocial%26utm_campaign%3Dsocial-share-article" data-network="facebook" data-click-tracked="true" class="share-link share-link-facebook" tabindex="0" 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Her work has been featured in "Kaplan AP Biology" and "The Internet for Cellular and Molecular Biologists."" tabindex="0" data-inline-tooltip="true"> <a href="https://www.thoughtco.com/regina-bailey-372397" rel="nocaes" data-trigger-link="true" class="mntl-attribution__item-name" tabindex="-1" >Regina Bailey</a> <div id="mntl-author-tooltip_1-0" class="comp mntl-author-tooltip mntl-tooltip mntl-group "> <div class="mntl-author-tooltip__top mntl-author-tooltip__top--no-image"> <div id="mntl-author-tooltip__name_1-0" class="comp mntl-author-tooltip__name mntl-attribution__item "> <a href="https://www.thoughtco.com/regina-bailey-372397" rel="nocaes" class="mntl-attribution__item-name" tabindex="0" >Regina Bailey</a> </div> <span id="mntl-author-tooltip__job-title_1-0" class="comp mntl-author-tooltip__job-title mntl-text-block">Biology Expert</span> <ul id="mntl-author-tooltip__education_1-0" class="comp mntl-author-tooltip__education mntl-block"><li id="mntl-author-tooltip__education-item_1-0" class="comp mntl-author-tooltip__education-item mntl-text-block">B.A., Biology, Emory University</li> <li id="mntl-author-tooltip__education-item_2-0" class="comp mntl-author-tooltip__education-item mntl-text-block">A.S., Nursing, Chattahoochee Technical College</li></ul> <div class="mntl-author-tooltip__bio"> Regina Bailey is a board-certified registered nurse, science writer and educator. Her work has been featured in "Kaplan AP Biology" and "The Internet for Cellular and Molecular Biologists." </div> </div> <div class="mntl-author-tooltip__bottom"> <span class="mntl-author-tooltip__learn-more-text">Learn about our</span> <a href="/about-us-4779650#toc-editorial-guidelines" rel="nocaes" class="mntl-author-tooltip__learn-more-link" >Editorial Process</a> </div> </div></div> </div> <div class="mntl-attribution__item-date">Updated on May 04, 2019</div></div> </div></div> </div><div class="loc article-content"><div id="list-sc_1-0" class="comp list-sc mntl-block article-content list "><div id="article-intro_1-0" class="comp article-intro mntl-block article-content__description"></div> <div id="list-sc__content_1-0" class="comp list-sc__content mntl-sc-page mntl-block " data-sc-sticky-offset="85" data-sc-ad-label-height="24" data-sc-ad-track-spacing="100" data-sc-min-track-height="250" data-sc-max-track-height="600" data-sc-breakpoint="50em" data-sc-load-immediate="3" data-sc-content-positions="[1, 1050, 1250, 1550, 1950, 2350, 2750, 3150]" data-bind-scroll-on-start="true"><div id="list-sc-item_1-0" class="comp list-sc-item mntl-block mntl-sc-list-item"><div id="list-marker_1-0" class="comp list-marker list-marker--numbers"> <div class="content-list-number"> <div class="item-number">01</div> <div class="total">of 02</div> </div> </div> <span class="heading-toc" id="toc-stem-cells"></span><h2 id="mntl-sc-block_1-0" class="comp mntl-sc-block reference-sc-block-heading mntl-sc-block-heading mntl-sc-list-item-title"> <span class="mntl-sc-block-heading__text"> Stem Cells </span> </h2> <figure id="mntl-sc-block_2-0" class="comp mntl-sc-block reference-sc-block-image mntl-sc-block-universal-image mntl-sc-block-image--no-theme no-theme mntl-sc-block-image figure-landscape figure-high-res"> <div class="figure-media"> <div class="img-placeholder" style="padding-bottom:66.6%;"> <img src="https://www.thoughtco.com/thmb/tVghRCSR3bgtgMB5IrpehEF_T9M=/1500x0/filters:no_upscale():max_bytes(150000):strip_icc()/85332125-57bf22f93df78cc16e1df6ce.jpg" width="4368" height="2912" srcset="https://www.thoughtco.com/thmb/ZdG6EROI6ToGn9t9eEB34-sQtkA=/750x0/filters:no_upscale():max_bytes(150000):strip_icc()/85332125-57bf22f93df78cc16e1df6ce.jpg 750w" sizes="750px" alt="Obama Executive Order Lifts Strict Limits On Stem Cell Research" class=" universal-image__image" data-expand="300" id=mntl-sc-block-image_1-0 data-tracking-container="true" data-img-lightbox="true" data-click-tracked="true" /> </div> </div> <figcaption id="mntl-figure-caption_1-0" class="comp mntl-figure-caption type--mouse figure-article-caption"> <svg class="icon icon-camera figure-article-caption-icon" > <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-camera" href="#icon-camera"></use> </svg> <span class="figure-article-caption-text">MADISON, WI - MARCH 10: Smoke rises off of a new batch of embryonic stem cells that are being removed from deep freeze to be thawed before being worked on at the Wisconsin National Primate Research Center.</span> <span class="figure-article-caption-owner">Darren Hauck / Stringer/ Getty Images News/ Getty Images</span> </figcaption></figure> <span class="heading-toc" id="toc-what-are-stem-cells"></span><h2 id="mntl-sc-block_3-0" class="comp mntl-sc-block reference-sc-block-heading mntl-sc-block-heading mntl-sc-list-item-title"> <span class="mntl-sc-block-heading__text"> What Are Stem Cells? </span> </h2> <p id="mntl-sc-block_4-0" class="comp mntl-sc-block mntl-sc-block-html"> Stem cells are unique cells of the body in that they are unspecialized and have the ability to develop into several different types of <a href="https://www.thoughtco.com/facts-about-cells-373372" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">cells</a>. They are different from specialized cells, such as <a href="https://www.thoughtco.com/heart-anatomy-373485" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="2">heart</a> or <a href="https://www.thoughtco.com/blood-373480" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="3">blood</a> cells, in that they can replicate many times, for long periods of time. This ability is what is known as proliferation. Unlike other cells, stem cells also have the ability to differentiate or develop into specialized cells for specific <a href="https://www.thoughtco.com/organ-systems-373571" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="4">organs</a> or to develop into <a href="https://www.thoughtco.com/animal-anatomy-epithelial-tissue-373206" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="5">tissues</a>. In some tissues, such as <a href="https://www.thoughtco.com/muscle-tissue-anatomy-373195" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="6">muscle</a> or <a href="https://www.thoughtco.com/anatomy-of-the-brain-373479" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="7">brain</a> tissue, stem cells can even regenerate to aid in the replacement of damaged cells. <a href="https://www.thoughtco.com/stem-cell-research-373345" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="8">Stem cell research</a> attempts to take advantage of the renewal properties of stem cells by utilizing them to generate cells for tissue repair and the treatment of disease. </p> <span class="heading-toc" id="toc-where-are-stem-cells-found"></span><h2 id="mntl-sc-block_5-0" class="comp mntl-sc-block reference-sc-block-heading mntl-sc-block-heading mntl-sc-list-item-title"> <span class="mntl-sc-block-heading__text"> Where Are Stem Cells Found? </span> </h2> <p id="mntl-sc-block_6-0" class="comp mntl-sc-block mntl-sc-block-html"> Stem cells come from several sources in the body. The names of the cells below indicate the sources from which they are derived. </p> <p id="mntl-sc-block_7-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Embryonic Stem Cells</strong> </p> <p id="mntl-sc-block_8-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells come from embryos in the early stages of development. They have the ability to differentiate into any type of cell in the initial stages of development and become slightly more specialized as they mature. </p> <p id="mntl-sc-block_9-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Fetal Stem Cells</strong> </p> <p id="mntl-sc-block_10-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells come from a fetus. At about nine weeks, a maturing embryo enters into the fetal stage of development. Fetal stem cells are found in fetal tissues, blood and bone marrow. They have the potential to develop into almost any type of cell. </p> <p id="mntl-sc-block_11-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Umbilical Cord Blood Stem Cells</strong> </p> <p id="mntl-sc-block_12-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells are derived from umbilical cord blood. Umbilical cord stem cells are similar to those found in mature or adult stem cells. They are specialized cells that develop into specific <a href="https://www.thoughtco.com/types-of-cells-in-the-body-373388" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">types of cells</a>. </p> <p id="mntl-sc-block_13-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Placental Stem Cells</strong> </p> <p id="mntl-sc-block_14-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells are contained within the placenta. Like cord blood stem cells, these cells are specialized cells that develop into specific types of cells. Placentas, however, contain several times more stem cells than do umbilical cords. </p> <p id="mntl-sc-block_15-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Adult Stem Cells</strong> </p> <p id="mntl-sc-block_16-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells are present in mature body tissues in infants, children, and adults. They may also be found in fetal and umbilical cord blood cells. Adult stem cells are specific to a particular tissue or organ and produce the cells within that particular tissue or organ. These stem cells help to maintain and repair organs and tissues throughout a person's life. </p> <p id="mntl-sc-block_17-0" class="comp mntl-sc-block mntl-sc-block-html"> <sub><strong>Source:</strong></sub> </p> <ul id="mntl-sc-block_18-0" class="comp mntl-sc-block mntl-sc-block-html"> <li><sub>Stem Cell Basics: Introduction. In <em>Stem Cell Information</em> [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2002. Available at (http://stemcells.nih.gov/info/basics/pages/basics1.aspx) </sub></li> </ul></div> <div id="adslot_1-0" class="comp adslot mntl-block mntl-sc-block-adslot"></div> <div id="list-sc-item_2-0" class="comp list-sc-item mntl-block mntl-sc-list-item"><div id="list-marker_2-0" class="comp list-marker list-marker--numbers"> <div class="content-list-number"> <div class="item-number">02</div> <div class="total">of 02</div> </div> </div> <span class="heading-toc" id="toc-types-of-stem-cells"></span><h2 id="mntl-sc-block_19-0" class="comp mntl-sc-block reference-sc-block-heading mntl-sc-block-heading mntl-sc-list-item-title"> <span class="mntl-sc-block-heading__text"> Types of Stem Cells </span> </h2> <figure id="mntl-sc-block_20-0" class="comp mntl-sc-block reference-sc-block-image mntl-sc-block-universal-image mntl-sc-block-image--no-theme no-theme mntl-sc-block-image figure-landscape figure-high-res"> <div class="figure-media"> <div class="img-placeholder" style="padding-bottom:75.0%;"> <img data-src="https://www.thoughtco.com/thmb/hAtRBJE0Ywpqlowlt5Y6USmtptA=/1500x0/filters:no_upscale():max_bytes(150000):strip_icc()/Humanstemcell-5897dce15f9b5874eeafe338.jpg" width="3072" height="2304" data-srcset="https://www.thoughtco.com/thmb/2qXTsrfaShPtealCCDNtcyRztTQ=/750x0/filters:no_upscale():max_bytes(150000):strip_icc()/Humanstemcell-5897dce15f9b5874eeafe338.jpg 750w" data-sizes="750px" alt="Human embryonic stem cells in cell culture" class="lazyload universal-image__image" data-expand="300" id=mntl-sc-block-image_2-0 data-tracking-container="true" data-img-lightbox="true" data-click-tracked="true" /> <noscript> <img src="https://www.thoughtco.com/thmb/hAtRBJE0Ywpqlowlt5Y6USmtptA=/1500x0/filters:no_upscale():max_bytes(150000):strip_icc()/Humanstemcell-5897dce15f9b5874eeafe338.jpg" width="3072" height="2304" class="img--noscript universal-image__image" srcset="https://www.thoughtco.com/thmb/2qXTsrfaShPtealCCDNtcyRztTQ=/750x0/filters:no_upscale():max_bytes(150000):strip_icc()/Humanstemcell-5897dce15f9b5874eeafe338.jpg 750w" sizes="750px" alt="Human embryonic stem cells in cell culture" /> </noscript> </div> </div> <figcaption id="mntl-figure-caption_2-0" class="comp mntl-figure-caption type--mouse figure-article-caption"> <svg class="icon icon-camera figure-article-caption-icon" > <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-camera" href="#icon-camera"></use> </svg> <span class="figure-article-caption-text">Human embryonic stem cells in cell culture.</span> <span class="figure-article-caption-owner">By <a href="https://en.wikipedia.org/wiki/User:Ryddragyn" title="wikipedia:User:Ryddragyn" data-component="link" data-source="inlineLink" data-type="externalLink" data-ordinal="1">Ryddragyn</a> at <a href="https://en.wikipedia.org/wiki/Main_Page" title="wikipedia:" data-component="link" data-source="inlineLink" data-type="externalLink" data-ordinal="2">English Wikipedia</a> - Transferred from <a href="//en.wikipedia.org" data-component="link" data-source="inlineLink" data-type="externalLink" data-ordinal="3">en.wikipedia</a> to Commons., Public Domain, <a href="https://commons.wikimedia.org/w/index.php?curid=2148036" data-component="link" data-source="inlineLink" data-type="externalLink" data-ordinal="4">Link</a></span> </figcaption></figure> <span class="heading-toc" id="toc-types-of-stem-cells"></span><h2 id="mntl-sc-block_21-0" class="comp mntl-sc-block reference-sc-block-heading mntl-sc-block-heading mntl-sc-list-item-title"> <span class="mntl-sc-block-heading__text"> Types of Stem Cells </span> </h2> <p id="mntl-sc-block_22-0" class="comp mntl-sc-block mntl-sc-block-html"> Stem cells can be categorized into five types based on their ability to differentiate or their potency. The stem cell types are as follows: </p> <p id="mntl-sc-block_23-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Totipotent Stem Cells</strong> </p> <p id="mntl-sc-block_24-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells have the ability to differentiate into any type of <a href="https://www.thoughtco.com/facts-about-cells-373372" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">cell</a> in the body. Totipotent stem cells develop during <a href="https://www.thoughtco.com/sexual-reproduction-373284" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="2">sexual reproduction</a> when male and female <a href="https://www.thoughtco.com/gametes-373465" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="3">gametes</a> fuse during <a href="https://www.thoughtco.com/sexual-reproduction-types-of-fertilization-373440" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="4">fertilization</a> to form a zygote. The zygote is totipotent because its cells can become any type of cell and they have limitless replicative abilities. As the zygote continues to divide and mature, its cells develop into more specialized cells called pluripotent stem cells. </p> <p id="mntl-sc-block_25-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Pluripotent Stem Cells</strong> </p> <p id="mntl-sc-block_26-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells have the ability to differentiate into several different types of cells. Specialization in pluripotent stem cells is minimal and therefore they can develop into almost any type of cell. Embryonic stem cells and fetal stem cells are two types of pluripotent cells. </p> <p id="mntl-sc-block_27-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Induced pluripotent stem cells (iPS cells)</strong> are genetically altered adult stem cells that are induced or prompted in a laboratory to take on the characteristics of embryonic stem cells. Although iPS cells behave like and express some of the same <a href="https://www.thoughtco.com/genes-373456" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">genes</a> that are expressed normally in embryonic stem cells, they are not exact duplicates of embryonic stem cells. </p> <p id="mntl-sc-block_28-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Multipotent Stem Cells</strong> </p> <p id="mntl-sc-block_29-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells have the ability to differentiate into a limited number of specialized cell types. Multipotent stem cells typically develop into any cell of a particular group or type. For example, <a href="https://www.thoughtco.com/bone-marrow-anatomy-373236" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">bone marrow</a> stem cells can produce any type of <a href="https://www.thoughtco.com/blood-373480" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="2">blood</a> cell. However, bone marrow cells don't produce <a href="https://www.thoughtco.com/heart-anatomy-373485" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="3">heart</a> cells. Adult stem cells and umbilical cord stem cells are examples of multipotent cells. </p> <p id="mntl-sc-block_30-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Mesenchymal stem cells</strong> are multipotent cells of bone marrow that have the ability to differentiate into several types of specialized cells related to, but not including, blood cells. These stem cells give rise to cells that form specialized <a href="https://www.thoughtco.com/connective-tissue-anatomy-373207" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">connective tissues</a>, as well as cells that support the formation of blood. </p> <p id="mntl-sc-block_31-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Oligopotent Stem Cells</strong> </p> <p id="mntl-sc-block_32-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells have the ability to differentiate into just a few types of cells. A lymphoid stem cell is an example of an oligopotent stem cell. This type of stem cell can not develop into any type of blood cell as bone marrow stem cells can. They only give rise to blood cells of the <a href="https://www.thoughtco.com/lymphatic-system-373581" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">lymphatic system</a>, such as T cells. </p> <p id="mntl-sc-block_33-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Unipotent Stem Cells</strong> </p> <p id="mntl-sc-block_34-0" class="comp mntl-sc-block mntl-sc-block-html"> These stem cells have unlimited reproductive capabilities, but can only differentiate into a single type of cell or <a href="https://www.thoughtco.com/animal-anatomy-epithelial-tissue-373206" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="1">tissue</a>. Unipotent stem cells are derived from multipotent stem cells and formed in adult tissue. <a href="https://www.thoughtco.com/integumentary-system-373580" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="2">Skin</a> cells are one of the most prolific examples of unipotent stem cells. These cells must readily undergo <a href="https://www.thoughtco.com/understanding-the-cell-cycle-373391" data-component="link" data-source="inlineLink" data-type="internalLink" data-ordinal="3">cell division</a> to replace damaged cells. </p> <p id="mntl-sc-block_35-0" class="comp mntl-sc-block mntl-sc-block-html"> <strong>Sources:</strong> </p> <ul id="mntl-sc-block_36-0" class="comp mntl-sc-block mntl-sc-block-html"> <li><sub>Stem Cell Basics: Introduction. In <em>Stem Cell Information</em> [World Wide Web site]. Bethesda, MD: National Institutes of Health, U.S. Department of Health and Human Services, 2002. Available at (http://stemcells.nih.gov/info/basics/pages/basics1.aspx) </sub></li><li><sub>Image: Nissim Benvenisty / Russo E (2005) Follow the Money—The Politics of Embryonic Stem Cell Research. PLoS Biol 3(7): e234. doi:10.1371/journal.pbio.0030234 </sub></li> </ul></div> <div id="adslot_2-0" class="comp adslot mntl-block mntl-sc-block-adslot"></div></div> <div id="article-outro_1-0" class="comp article-outro mntl-block"></div> <div id="sources-and-citation_1-0" class="comp sources-and-citation mntl-block"><div id="citation-widget_1-0" class="comp citation-widget js-citation-widget" data-tracking-container="true"> <div class="citation-widget__container js-container"> <button class="citation-widget__button js-button"> <span class="citation-widget__cite-label">Cite this Article </span> <svg class="icon icon-cite citation-widget__icon-cite" > <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-cite" href="#icon-cite"></use> </svg> </button> <div class="citation-widget__window js-window"> <svg class="icon icon-close citation-widget__icon-close js-icon-close" > <use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-close" href="#icon-close"></use> </svg> <div class="citation-widget__heading">Format</div> <a href="#" class="citation-widget__format-link citation-widget__format-link--active js-format-link">mla</a> <a href="#" class="citation-widget__format-link js-format-link">apa</a> <a href="#" class="citation-widget__format-link js-format-link">chicago</a> <div class="citation-widget__heading">Your Citation</div> <div class="citation-widget__content js-content"> <span class="citation-widget__citation citation-widget__citation--active js-active" data-citation-format="mla">Bailey, Regina. "Stem Cells." ThoughtCo, Apr. 5, 2023, thoughtco.com/understanding-stem-cells-373346.</span> <span class="citation-widget__citation" data-citation-format="apa">Bailey, Regina. (2023, April 5). Stem Cells. Retrieved from https://www.thoughtco.com/understanding-stem-cells-373346</span> <span class="citation-widget__citation" data-citation-format="chicago">Bailey, Regina. "Stem Cells." 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js-outbrain-widget" data-src="https://www.thoughtco.com/understanding-stem-cells-373346" data-widget-id="AR_1"></div> </div> <section id="masonry-list-section_1-0" class="comp masonry-list-section mntl-block" data-tracking-container="true"><ul id="mntl-masonry-tax-card-list_1-0" class="comp mntl-masonry-tax-card-list mntl-masonry-card-list mntl-masonry-list mntl-block masonry-list"><li id="masonry-list__item_1-0" class="comp masonry-list__item mntl-block"><a id="mntl-card_1-0" class="comp mntl-card mntl-document-card is-inverted-small card card--no-image" data-doc-id="373345" data-tax-levels href="https://www.thoughtco.com/stem-cell-research-373345" data-ordinal="1" data-cta="Read Now ▸"> <div class="loc card__top"><div class="card__media mntl-universal-image universal-image__container"><div class="img-placeholder" style="padding-bottom:56.2%;"> <img 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