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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization | Obesity Surgery</title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization"/> <meta name="twitter:description" content="Obesity Surgery - The obesity epidemic causes significant morbidity and mortality. Knowledge of cellular function and gene expression in obese adipose tissue will yield insights into obesity..."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig1_HTML.gif"/> <meta name="journal_id" content="11695"/> <meta name="dc.title" content="Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization"/> <meta name="dc.source" content="Obesity Surgery 2009 20:1"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2009-10-29"/> <meta name="dc.type" content="OriginalPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2009 Springer Science + Business Media, LLC"/> <meta name="dc.rights" content="2009 Springer Science + Business Media, LLC"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="The obesity epidemic causes significant morbidity and mortality. Knowledge of cellular function and gene expression in obese adipose tissue will yield insights into obesity pathogenesis and suggest therapeutic targets. The aim of this work is to study the processes determining fat accumulation in adipose tissue from obese patients. Omental fat was collected from two cohorts of obese bariatric surgery patients and sex-matched normal-weight donors. Isolated adipocytes were compared for cell size, volume, and long-chain fatty acid (LCFA) uptake. Omental fat RNAs were screened by 10K microarray (cohort 1: three obese, three normal) or Whole Genome microarray (cohort 2: seven obese, four normal). Statistical differences in gene and pathway expression were identified in cohort 1 using the GeneSifter Software (Geospiza) with key results confirmed in cohort 2 samples by microarray, quantitative real-time polymerase chain reaction, and pathway analysis. Obese omental adipocytes had increased surface area, volume, and V max for saturable LCFA uptake. Dodecenoyl-coenzyme A delta isomerase, central to LCFA metabolism, was approximately 1.6-fold underexpressed in obese fat in cohorts 1 and 2. Additionally, the Kyoto Encyclopedia of Genes and Genomics pathway analysis identified oxidative phosphorylation and fatty acid metabolism pathways as having coordinate, nonrandom downregulation of gene expression in both cohorts. In obese omental fat, saturable adipocyte LCFA uptake was greater than in controls, and expression of key genes involved in lipolysis, β-oxidation, and metabolism of fatty acids was reduced. Thus, both increased uptake and reduced metabolism of LCFAs contribute to the accumulation of LCFAs in obese adipocytes."/> <meta name="prism.issn" content="1708-0428"/> <meta name="prism.publicationName" content="Obesity Surgery"/> <meta name="prism.publicationDate" content="2009-10-29"/> <meta name="prism.volume" content="20"/> <meta name="prism.number" content="1"/> <meta name="prism.section" content="OriginalPaper"/> <meta name="prism.startingPage" content="93"/> <meta name="prism.endingPage" content="107"/> <meta name="prism.copyright" content="2009 Springer Science + Business Media, LLC"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s11695-009-0002-9"/> <meta name="prism.doi" content="doi:10.1007/s11695-009-0002-9"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s11695-009-0002-9.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s11695-009-0002-9"/> <meta name="citation_journal_title" content="Obesity Surgery"/> <meta name="citation_journal_abbrev" content="OBES SURG"/> <meta name="citation_publisher" content="Springer-Verlag"/> <meta name="citation_issn" content="1708-0428"/> <meta name="citation_title" content="Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization"/> <meta name="citation_volume" content="20"/> <meta name="citation_issue" content="1"/> <meta name="citation_publication_date" content="2010/01"/> <meta name="citation_online_date" content="2009/10/29"/> <meta name="citation_firstpage" content="93"/> <meta name="citation_lastpage" content="107"/> <meta name="citation_article_type" content="Basic Science Research"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s11695-009-0002-9"/> <meta name="DOI" content="10.1007/s11695-009-0002-9"/> <meta name="size" content="233550"/> <meta name="citation_doi" content="10.1007/s11695-009-0002-9"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s11695-009-0002-9&api_key="/> <meta name="description" content="The obesity epidemic causes significant morbidity and mortality. Knowledge of cellular function and gene expression in obese adipose tissue will yield insi"/> <meta name="dc.creator" content="Walewski, José L."/> <meta name="dc.creator" content="Ge, Fengxia"/> <meta name="dc.creator" content="Gagner, Michel"/> <meta name="dc.creator" content="Inabnet, William B."/> <meta name="dc.creator" content="Pomp, Alfons"/> <meta name="dc.creator" content="Branch, Andrea D."/> <meta name="dc.creator" content="Berk, Paul D."/> <meta name="dc.subject" content="Surgery"/> <meta name="citation_reference" content="citation_journal_title=Proc Natl Acad Sci U S A; citation_title=Hepatocellular influx of [14C]oleate reflects membrane transport rather than intracellular metabolism or binding; citation_author=W Stremmel, PD Berk; citation_volume=83; citation_issue=10; citation_publication_date=1986; citation_pages=3086-90; citation_doi=10.1073/pnas.83.10.3086; citation_id=CR1"/> <meta name="citation_reference" content="citation_journal_title=Proc Natl Acad Sci U S A; citation_title=Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut; citation_author=W Schwieterman, D Sorrentino, BJ Potter; citation_volume=85; citation_issue=2; citation_publication_date=1988; citation_pages=359-63; citation_doi=10.1073/pnas.85.2.359; citation_id=CR2"/> <meta name="citation_reference" content="citation_journal_title=J Clin Invest; citation_title=Oleate uptake by cardiac myocytes is carrier mediated and involves a 40-kD plasma membrane fatty acid binding protein similar to that in liver, adipose tissue, and gut; citation_author=D Sorrentino, D Stump, BJ Potter; citation_volume=82; citation_issue=3; citation_publication_date=1988; citation_pages=928-35; citation_doi=10.1172/JCI113700; citation_id=CR3"/> <meta name="citation_reference" content="citation_journal_title=J Clin Invest; citation_title=Uptake of fatty acids by jejunal mucosal cells is mediated by a fatty acid binding membrane protein; citation_author=W Stremmel; citation_volume=82; citation_issue=6; citation_publication_date=1988; citation_pages=2001-10; citation_doi=10.1172/JCI113820; citation_id=CR4"/> <meta name="citation_reference" content="Nunes RM IL, Sorrentino D, Berk PD. 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Two independent gene signatures in pediatric t(4;11) acute lymphoblastic leukemia patients. Eur J Haematol. 2009;in press."/> <meta name="citation_reference" content="citation_journal_title=Immunol Invest; citation_title=T helper type 2 differentiation is associated with induction of antibacterial defense mechanisms in blood lymphocytes of patients with sarcoidosis; citation_author=SN Ukena, C Koenecke, R Geffers; citation_volume=38; citation_issue=1; citation_publication_date=2009; citation_pages=49-66; citation_doi=10.1080/08820130802572103; citation_id=CR61"/> <meta name="citation_reference" content="citation_journal_title=Biomarker Insights; citation_title=Hematopoietic lineage transcriptome stability and representation in PAXgene collected peripheral blood utilising SPIA single-stranded cDNA probes for microarray; citation_author=L Kennedy, JK Vass, DR Haggart; citation_volume=3; citation_publication_date=2008; citation_pages=403-17; citation_id=CR62"/> <meta name="citation_author" content="Walewski, José L."/> <meta name="citation_author_institution" content="Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA"/> <meta name="citation_author" content="Ge, Fengxia"/> <meta name="citation_author_institution" content="Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA"/> <meta name="citation_author" content="Gagner, Michel"/> <meta name="citation_author_institution" content="Department of Surgery, Weill Cornell Medical College, New York, USA"/> <meta name="citation_author_institution" content="Department of Surgery, Mount Sinai Medical Center, Miami Beach, USA"/> <meta name="citation_author" content="Inabnet, William B."/> <meta name="citation_author_institution" content="Department of Surgery, Columbia University College of Physicians and Surgeons, New York, USA"/> <meta name="citation_author" content="Pomp, Alfons"/> <meta name="citation_author_institution" content="Department of Surgery, Weill Cornell Medical College, New York, USA"/> <meta name="citation_author" content="Branch, Andrea D."/> <meta name="citation_author_institution" content="Department of Medicine, Mount Sinai School of Medicine, New York, USA"/> <meta name="citation_author" content="Berk, Paul D."/> <meta name="citation_author_email" content="pb2158@columbia.edu"/> <meta name="citation_author_institution" content="Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA"/> <meta name="citation_author_institution" content="Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, USA"/> <meta name="format-detection" content="telephone=no"/> <meta name="citation_cover_date" content="2010/01/01"/> <meta property="og:url" content="https://link.springer.com/article/10.1007/s11695-009-0002-9"/> <meta property="og:type" content="article"/> <meta property="og:site_name" content="SpringerLink"/> <meta property="og:title" content="Adipocyte Accumulation of Long-Chain Fatty Acids in Obesity is Multifactorial, Resulting from Increased Fatty Acid Uptake and Decreased Activity of Genes Involved in Fat Utilization - Obesity Surgery"/> <meta property="og:description" content="Background The obesity epidemic causes significant morbidity and mortality. Knowledge of cellular function and gene expression in obese adipose tissue will yield insights into obesity pathogenesis and suggest therapeutic targets. The aim of this work is to study the processes determining fat accumulation in adipose tissue from obese patients. Methods Omental fat was collected from two cohorts of obese bariatric surgery patients and sex-matched normal-weight donors. Isolated adipocytes were compared for cell size, volume, and long-chain fatty acid (LCFA) uptake. Omental fat RNAs were screened by 10K microarray (cohort 1: three obese, three normal) or Whole Genome microarray (cohort 2: seven obese, four normal). Statistical differences in gene and pathway expression were identified in cohort 1 using the GeneSifter Software (Geospiza) with key results confirmed in cohort 2 samples by microarray, quantitative real-time polymerase chain reaction, and pathway analysis. Results Obese omental adipocytes had increased surface area, volume, and V max for saturable LCFA uptake. Dodecenoyl-coenzyme A delta isomerase, central to LCFA metabolism, was approximately 1.6-fold underexpressed in obese fat in cohorts 1 and 2. Additionally, the Kyoto Encyclopedia of Genes and Genomics pathway analysis identified oxidative phosphorylation and fatty acid metabolism pathways as having coordinate, nonrandom downregulation of gene expression in both cohorts. Conclusions In obese omental fat, saturable adipocyte LCFA uptake was greater than in controls, and expression of key genes involved in lipolysis, β-oxidation, and metabolism of fatty acids was reduced. Thus, both increased uptake and reduced metabolism of LCFAs contribute to the accumulation of LCFAs in obese adipocytes."/> <meta property="og:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig1_HTML.gif"/> <meta name="format-detection" content="telephone=no"> <link rel="apple-touch-icon" sizes="180x180" href=/oscar-static/img/favicons/darwin/apple-touch-icon-92e819bf8a.png> <link rel="icon" type="image/png" sizes="192x192" href=/oscar-static/img/favicons/darwin/android-chrome-192x192-6f081ca7e5.png> <link rel="icon" type="image/png" sizes="32x32" href=/oscar-static/img/favicons/darwin/favicon-32x32-1435da3e82.png> <link rel="icon" type="image/png" sizes="16x16" href=/oscar-static/img/favicons/darwin/favicon-16x16-ed57f42bd2.png> <link rel="shortcut icon" data-test="shortcut-icon" href=/oscar-static/img/favicons/darwin/favicon-c6d59aafac.ico> <meta name="theme-color" content="#e6e6e6">   <link rel="stylesheet" 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Knowledge of cellular function and gene expression in obese adipose tissue will yield insights into obesity pathogenesis and suggest therapeutic targets. The aim of this work is to study the processes determining fat accumulation in adipose tissue from obese patients. Omental fat was collected from two cohorts of obese bariatric surgery patients and sex-matched normal-weight donors. Isolated adipocytes were compared for cell size, volume, and long-chain fatty acid (LCFA) uptake. Omental fat RNAs were screened by 10K microarray (cohort 1: three obese, three normal) or Whole Genome microarray (cohort 2: seven obese, four normal). Statistical differences in gene and pathway expression were identified in cohort 1 using the GeneSifter Software (Geospiza) with key results confirmed in cohort 2 samples by microarray, quantitative real-time polymerase chain reaction, and pathway analysis. Obese omental adipocytes had increased surface area, volume, and V\n max for saturable LCFA uptake. Dodecenoyl-coenzyme A delta isomerase, central to LCFA metabolism, was approximately 1.6-fold underexpressed in obese fat in cohorts 1 and 2. Additionally, the Kyoto Encyclopedia of Genes and Genomics pathway analysis identified oxidative phosphorylation and fatty acid metabolism pathways as having coordinate, nonrandom downregulation of gene expression in both cohorts. In obese omental fat, saturable adipocyte LCFA uptake was greater than in controls, and expression of key genes involved in lipolysis, β-oxidation, and metabolism of fatty acids was reduced. Thus, both increased uptake and reduced metabolism of LCFAs contribute to the accumulation of LCFAs in obese adipocytes.","datePublished":"2009-10-29T00:00:00Z","dateModified":"2009-10-29T00:00:00Z","pageStart":"93","pageEnd":"107","sameAs":"https://doi.org/10.1007/s11695-009-0002-9","keywords":["Obesity","DNA","Microarrays","Dodecenoyl-coenzyme A delta isomerase","Fatty acid transport","Pathways","Surgery"],"image":["https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig1_HTML.gif","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig2_HTML.gif","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig3_HTML.gif","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig4_HTML.gif","https://media.springernature.com/lw1200/springer-static/image/art%3A10.1007%2Fs11695-009-0002-9/MediaObjects/11695_2009_2_Fig5_HTML.gif"],"isPartOf":{"name":"Obesity Surgery","issn":["1708-0428","0960-8923"],"volumeNumber":"20","@type":["Periodical","PublicationVolume"]},"publisher":{"name":"Springer-Verlag","logo":{"url":"https://www.springernature.com/app-sn/public/images/logo-springernature.png","@type":"ImageObject"},"@type":"Organization"},"author":[{"name":"José L. 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class="c-article-identifiers__item c-article-identifiers__item--cite"> <a href="#citeas" data-track="click" data-track-action="cite this article" data-track-category="article body" data-track-label="link">Cite this article</a> </li> </ul> <div class="app-article-masthead__buttons" data-test="download-article-link-wrapper" data-track-context="masthead"> </div> </div> <div class="app-article-masthead__brand"> <a href="/journal/11695" class="app-article-masthead__journal-link" data-track="click_journal_home" data-track-action="journal homepage" data-track-context="article page" data-track-label="link"> <picture> <source type="image/webp" media="(min-width: 768px)" width="120" height="159" srcset="https://media.springernature.com/w120/springer-static/cover-hires/journal/11695?as=webp, https://media.springernature.com/w316/springer-static/cover-hires/journal/11695?as=webp 2x"> <img width="72" height="95" src="https://media.springernature.com/w72/springer-static/cover-hires/journal/11695?as=webp" srcset="https://media.springernature.com/w144/springer-static/cover-hires/journal/11695?as=webp 2x" alt=""> </picture> <span class="app-article-masthead__journal-title">Obesity Surgery</span> </a> <a href="https://link.springer.com/journal/11695/aims-and-scope" class="app-article-masthead__submission-link" data-track="click_aims_and_scope" data-track-action="aims and scope" data-track-context="article page" data-track-label="link"> Aims and scope <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> <a href="https://submission.springernature.com/new-submission/11695/3" class="app-article-masthead__submission-link" data-track="click_submit_manuscript" data-track-context="article masthead on springerlink article page" data-track-action="submit manuscript" data-track-label="link"> Submit manuscript <svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-arrow-right-medium"></use></svg> </a> </div> </div> </div> </section> <div class="c-article-main u-container u-mt-24 u-mb-32 l-with-sidebar" id="main-content" data-component="article-container"> <main class="u-serif js-main-column" data-track-component="article body"> <div class="c-article-header"> <header> <ul class="c-article-author-list c-article-author-list--short" data-test="authors-list" data-component-authors-activator="authors-list"><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Jos__L_-Walewski-Aff1" data-author-popup="auth-Jos__L_-Walewski-Aff1" data-author-search="Walewski, José L.">José L. Walewski</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Fengxia-Ge-Aff1" data-author-popup="auth-Fengxia-Ge-Aff1" data-author-search="Ge, Fengxia">Fengxia Ge</a><sup class="u-js-hide"><a href="#Aff1">1</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Michel-Gagner-Aff2-Aff5" data-author-popup="auth-Michel-Gagner-Aff2-Aff5" data-author-search="Gagner, Michel">Michel Gagner</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup><sup class="u-js-hide"> <a href="#nAff5">nAff5</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-William_B_-Inabnet-Aff3" data-author-popup="auth-William_B_-Inabnet-Aff3" data-author-search="Inabnet, William B.">William B. Inabnet</a><sup class="u-js-hide"><a href="#Aff3">3</a></sup><sup class="u-js-hide"> <a href="#nAff7">nAff7</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Alfons-Pomp-Aff2" data-author-popup="auth-Alfons-Pomp-Aff2" data-author-search="Pomp, Alfons">Alfons Pomp</a><sup class="u-js-hide"><a href="#Aff2">2</a></sup>, </li><li class="c-article-author-list__item c-article-author-list__item--hide-small-screen"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Andrea_D_-Branch-Aff4" data-author-popup="auth-Andrea_D_-Branch-Aff4" data-author-search="Branch, Andrea D.">Andrea D. Branch</a><sup class="u-js-hide"><a href="#Aff4">4</a></sup> & </li><li class="c-article-author-list__show-more" aria-label="Show all 7 authors for this article" title="Show all 7 authors for this article">…</li><li class="c-article-author-list__item"><a data-test="author-name" data-track="click" data-track-action="open author" data-track-label="link" href="#auth-Paul_D_-Berk-Aff1-Aff6" data-author-popup="auth-Paul_D_-Berk-Aff1-Aff6" data-author-search="Berk, Paul D." data-corresp-id="c1">Paul D. Berk<svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-mail-medium"></use></svg></a><sup class="u-js-hide"><a href="#Aff1">1</a>,<a href="#Aff6">6</a></sup> </li></ul><button aria-expanded="false" class="c-article-author-list__button"><svg width="16" height="16" focusable="false" role="img" aria-hidden="true" class="u-icon"><use xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="#icon-eds-i-chevron-down-medium"></use></svg><span>Show authors</span></button> <div data-test="article-metrics"> <ul class="app-article-metrics-bar u-list-reset"> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-accesses-medium"></use> </svg>683 <span class="app-article-metrics-bar__label">Accesses</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-citations-medium"></use> </svg>50 <span class="app-article-metrics-bar__label">Citations</span></p> </li> <li class="app-article-metrics-bar__item"> <p class="app-article-metrics-bar__count"><svg class="u-icon app-article-metrics-bar__icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-altmetric-medium"></use> </svg>6 <span class="app-article-metrics-bar__label">Altmetric</span></p> </li> <li class="app-article-metrics-bar__item app-article-metrics-bar__item--metrics"> <p class="app-article-metrics-bar__details"><a href="/article/10.1007/s11695-009-0002-9/metrics" data-track="click" data-track-action="view metrics" data-track-label="link" rel="nofollow">Explore all metrics <svg class="u-icon app-article-metrics-bar__arrow-icon" width="24" height="24" aria-hidden="true" focusable="false"> <use xlink:href="#icon-eds-i-arrow-right-medium"></use> </svg></a></p> </li> </ul> </div> <div class="u-mt-32"> </div> </header> </div> <div data-article-body="true" data-track-component="article body" class="c-article-body"> <section aria-labelledby="Abs1" data-title="Abstract" lang="en"><div class="c-article-section" id="Abs1-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="Abs1">Abstract</h2><div class="c-article-section__content" id="Abs1-content"><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Background</h3><p>The obesity epidemic causes significant morbidity and mortality. Knowledge of cellular function and gene expression in obese adipose tissue will yield insights into obesity pathogenesis and suggest therapeutic targets. The aim of this work is to study the processes determining fat accumulation in adipose tissue from obese patients.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Methods</h3><p>Omental fat was collected from two cohorts of obese bariatric surgery patients and sex-matched normal-weight donors. Isolated adipocytes were compared for cell size, volume, and long-chain fatty acid (LCFA) uptake. Omental fat RNAs were screened by 10K microarray (cohort 1: three obese, three normal) or Whole Genome microarray (cohort 2: seven obese, four normal). Statistical differences in gene and pathway expression were identified in cohort 1 using the GeneSifter Software (Geospiza) with key results confirmed in cohort 2 samples by microarray, quantitative real-time polymerase chain reaction, and pathway analysis.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Results</h3><p>Obese omental adipocytes had increased surface area, volume, and <i>V</i> <sub>max</sub> for saturable LCFA uptake. Dodecenoyl-coenzyme A delta isomerase, central to LCFA metabolism, was approximately 1.6-fold underexpressed in obese fat in cohorts 1 and 2. Additionally, the Kyoto Encyclopedia of Genes and Genomics pathway analysis identified oxidative phosphorylation and fatty acid metabolism pathways as having coordinate, nonrandom downregulation of gene expression in both cohorts.</p><h3 class="c-article__sub-heading" data-test="abstract-sub-heading">Conclusions</h3><p>In obese omental fat, saturable adipocyte LCFA uptake was greater than in controls, and expression of key genes involved in lipolysis, β-oxidation, and metabolism of fatty acids was reduced. 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Inabnet</p><p class="js-present-address">Present address: Department of Surgery, Mount Sinai Medical Center, New York, NY, 10029, USA</p></li></ol><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA</p><p class="c-article-author-affiliation__authors-list">José L. Walewski, Fengxia Ge & Paul D. Berk</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Department of Surgery, Weill Cornell Medical College, New York, NY, 10065, USA</p><p class="c-article-author-affiliation__authors-list">Michel Gagner & Alfons Pomp</p></li><li id="Aff3"><p class="c-article-author-affiliation__address">Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY, 10032, USA</p><p class="c-article-author-affiliation__authors-list">William B. Inabnet</p></li><li id="Aff4"><p class="c-article-author-affiliation__address">Department of Medicine, Mount Sinai School of Medicine, New York, NY, 10029, USA</p><p class="c-article-author-affiliation__authors-list">Andrea D. Branch</p></li><li id="Aff6"><p class="c-article-author-affiliation__address">Division of Digestive and Liver Diseases, Columbia University Medical Center, Russ Berrie Medical Science Pavilion, 1150 Saint Nicholas Avenue, Room 412, New York, NY, 10032, USA</p><p class="c-article-author-affiliation__authors-list">Paul D. Berk</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-Jos__L_-Walewski-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">José L. Walewski</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Jos%C3%A9%20L.%20Walewski" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span class="c-article-identifiers"><a class="c-article-identifiers__item" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Jos%C3%A9%20L.%20Walewski" data-track="click" data-track-action="author link - pubmed" data-track-label="link" rel="nofollow">PubMed</a><span class="u-hide"> </span><a class="c-article-identifiers__item" href="http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Jos%C3%A9%20L.%20Walewski%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en" data-track="click" data-track-action="author link - scholar" data-track-label="link" rel="nofollow">Google Scholar</a></span></p></div></div></li><li id="auth-Fengxia-Ge-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">Fengxia Ge</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Fengxia%20Ge" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span class="c-article-identifiers"><a class="c-article-identifiers__item" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fengxia%20Ge" data-track="click" data-track-action="author link - pubmed" data-track-label="link" rel="nofollow">PubMed</a><span class="u-hide"> </span><a class="c-article-identifiers__item" href="http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Fengxia%20Ge%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en" data-track="click" data-track-action="author link - scholar" data-track-label="link" rel="nofollow">Google Scholar</a></span></p></div></div></li><li id="auth-Michel-Gagner-Aff2-Aff5"><span class="c-article-authors-search__title u-h3 js-search-name">Michel Gagner</span><div class="c-article-authors-search__list"><div class="c-article-authors-search__item c-article-authors-search__list-item--left"><a href="/search?dc.creator=Michel%20Gagner" class="c-article-button" data-track="click" data-track-action="author link - publication" data-track-label="link" rel="nofollow">View author publications</a></div><div class="c-article-authors-search__item c-article-authors-search__list-item--right"><p class="search-in-title-js c-article-authors-search__text">You can also search for this author in <span class="c-article-identifiers"><a class="c-article-identifiers__item" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Michel%20Gagner" data-track="click" data-track-action="author link - pubmed" data-track-label="link" rel="nofollow">PubMed</a><span class="u-hide"> </span><a class="c-article-identifiers__item" href="http://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Michel%20Gagner%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en" data-track="click" data-track-action="author link - scholar" data-track-label="link" rel="nofollow">Google Scholar</a></span></p></div></div></li><li id="auth-William_B_-Inabnet-Aff3"><span class="c-article-authors-search__title u-h3 js-search-name">William B. 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