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type="application/ld+json">{"@context":{"@vocab":"http://schema.org","articleId":{"@id":"Text","@type":"@id"},"topics":{"@id":"Text","@type":"@id"}},"@type":"NewsArticle","headline":"A European man could be cured of HIV thanks to a stem cell transplant for blood cancer","url":"https://www.nbcnews.com/nbc-out/out-health-and-wellness/hiv-remission-stem-cell-transplant-blood-cancer-rcna94989","thumbnailUrl":"https://media-cldnry.s-nbcnews.com/image/upload/t_social_share_1024x768_scale,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg","alternativeHeadline":"In remission from HIV, a sixth person could join the club of those possibly cured","articleBody":"A European man has been in a state of remission from HIV infection for nearly two years after receiving a stem cell transplant to treat blood cancer. If enough time passes with no signs of viable virus, he could join the rarefied club of five people who are considered either definitely or possibly cured of HIV. All six people had HIV when they received stem cell transplants to treat blood cancers such as leukemia or lymphoma. But unlike the five other cases, this new one involves a person whose donor did not have a rare genetic abnormality that generates resistance to HIV in the immune cells that the virus targets for infection. The man’s case will be presented next week at the International AIDS Society Conference on HIV Science in Brisbane, Australia. This major biennial gathering of scientists will also hear noteworthy presentations regarding post-treatment control of HIV in infant boys, circumcision’s impact on HIV risk in gay men, and the relationship between HIV and mpox (formerly known as monkeypox). It remains unethical for a person with HIV who does not already qualify for a stem cell transplant due to cancer to undergo such a treatment in hopes of curing the virus, given such treatment’s considerable toxicity. Scientists generally expect that any success in the effort to develop a widely scalable HIV cure therapy will likely take decades. Nevertheless, Dr. Sharon Lewin, president of the IAS and director of the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, called the new viral remission case “great news.” Such case reports, she said, “help in many ways in the work toward a cure.” The 'Geneva Patient' The man newly in remission from HIV has been dubbed the Geneva Patient, after the Swiss city where he has received his treatment. He is in his early 50s, was diagnosed with the virus in 1990 and began taking antiretroviral treatment in 2005. In 2018, he was diagnosed with a rare blood cancer known as an extramedullary myeloid tumor. He was treated with radiation, chemotherapy and a stem cell transplant. His case has been overseen by a research team led by Asier Sáez-Cirión, head of the viral reservoirs and immune control unit at the Institut Pasteur in Paris. HIV is vexingly difficult to cure. This is in large part because even when suppressed by antiretrovirals, the virus hides in nonreplicating immune cells, known collectively as the viral reservoir. Such standard HIV treatment only works on cells that are actively producing new viral copies. So the virus remains under the radar of antiretrovirals within these latently infected cells, each of which can take months or even years to return to a replicating state. Since the first such case was announced in 2008, three people have definitely been cured and two additional people, pending more time passing without a viral rebound, have possibly been cured of HIV. Prior to the Geneva Patient’s case, a handful of other people with HIV who developed cancer also received stem cell transplants from donors without the rare genetic mutation conferring natural resistance to the virus. But none from this group went more than 10 months after stopping antiretroviral treatment without a resurgent virus. Hopes that they had been cured were dashed. The man in Switzerland has now spent 20 months with no viral rebound, having been taken off of antiretrovirals in November 2021. Sáez-Cirión and his colleagues have conducted a battery of ultrasensitive tests in search of HIV in his body and have only been able to detect trace amounts of defective virus. But they still cannot rule out that the man retains even a single cell infected with viable virus, one that could spring to action at any moment and repopulate the body with HIV. “The possibility of viral rebound is indeed a concern,” Sáez-Cirión said. “The virus may persist in rare infected blood cells or anatomical sites that we have not analyzed.” It remains unclear why the Geneva Patient’s case has been so successful, at least thus far, while others who received similar treatment were not so fortunate. Dr. Steven Deeks, a leading HIV cure researcher at the University of California, San Francisco, who was not involved in the study of the Geneva Patient, said the details of the case “suggest that what we once assumed was impossible might in fact be possible.” Speculating about the drivers of this man’s lengthy HIV remission, Deeks said, “Eliminating most if not all of the reservoir with chemotherapy was certainly the key intervention.” Deeks also noted the man’s repeated episodes of what is known as graft-versus-host disease, a powerful and potentially dangerous immune reaction that occurs as a consequence of a stem cell transplant. This might have also played a crucial role, Deeks said, “as the newly rebuilt immune system may have been attacking and clearing the old immune system, including any residual T cells harboring HIV.” Sáez-Cirión said it is also possible that the immunosuppressive drugs that the Geneva Patient continues to receive to prevent graft-versus-host disease may be preventing any residual HIV from replicating. Post-treatment control of HIV Researchers in sub-Saharan Africa have identified a handful of boys born with HIV who did not experience viral rebound even after their antiretroviral treatment was interrupted for extended periods. This finding comes from a study of 281 mothers in South Africa who had passed HIV to their newborns. The infants were all put on antiretrovirals immediately after birth. But the investigators eventually discovered that the caretakers of five boys had not provided them with HIV treatment for periods spanning three to 10 months, and yet each of these children maintained an undetectable or very low viral load. Four of the boys were immediately put back on HIV treatment. However, one other has been kept off of treatment and has now passed 19 months without a viral rebound. Three of the others have been enrolled in a study in which their treatment will once again be interrupted, but under close monitoring. Dr. Gabriela Cromhout, a research clinician and doctoral candidate at the University of KwaZulu-Natal and one of the lead authors of the study, said three of the boys can be classified as so-called post-treatment controllers of HIV, because they had sustained an undetectable viral load for more than six months while off antiretrovirals. In advance of their conference presentation, Cromhout and her colleagues did not, however, conduct any ultrasensitive tests to search for the residual presence of HIV in the children’s bodies. Such tests are ongoing. Dr. Deborah Persaud, a pediatric infectious disease specialist at the Johns Hopkins University School of Medicine and the head of a major ongoing study seeking to cure HIV in infants, said, “This is an enormous advance for the field of HIV remission and cure.” However, Persaud, who was not involved in the South African study, said to back their findings, the study’s investigators would need to present data at the conference confirming that the five boys were infected and that they were indeed off antiretrovirals for the extended periods — data that Cromhout confirmed her team has on hand. Circumcision and HIV risk In the mid-2000s, a trio of randomized controlled trials in sub-Saharan Africa determined that circumcising men reduced the risk of female-to-male sexual transmission of HIV by about 50% to 60%. Now, a research team in China is the first to have completed such a study of gay and bisexual men. They enrolled about 250 uncircumcised men who have sex with men who reported primarily being the insertive partner in intercourse (known as being the “top”). Half were randomly selected to be circumcised. After one year, five study participants contracted HIV, all of them in the control group. The study registered no significant differences in sexual behaviors between the two study groups that might have affected the men’s relative risk of HIV. The difference in the HIV acquisition rate between the two study groups, the investigators calculated, was statistically significant. On a media call Wednesday, Dr. Huachun Zou, a professor of epidemiology at the Sun Yat-sen University School of Public Health in Shenzhen, China, said larger studies may be necessary to fully establish whether circumcision reduces the risk of HIV among gay and bisexual men. But he said it is “very unlikely” that researchers will, indeed, launch such research because of the global popularity of the HIV prevention pill, known as PrEP, as a means of reducing risk of the virus among gay and bi men. He said PrEP is not, however, widely used in China, a nation that also has a low circumcision rate. HIV and mpox hospitalization This study looked at surveillance data from the World Health Organization regarding 82,290 mpox cases from 2022. There was information about the HIV status for 39% of these people, among whom 52% — 16,633 people, or 20% of the total — had that virus. The study found that overall, having HIV was not associated with a greater likelihood of being hospitalized with mpox. However, being immunocompromised, including from HIV or from another factor, was tied to about two to four times the hospitalization risk, compared with being HIV-negative and having a healthy immune system. Fifty-eight of the people with HIV died, as did four of the 15,371 people without HIV. A paper published in The Lancet in February found that people with HIV had a very high risk of death from mpox if their immune system was suppressed. People with HIV who are treated with antiretrovirals can maintain essentially healthy immune systems.","dateModified":"2023-07-19T23:03:15.000Z","datePublished":"2023-07-19T22:00:40.000Z","articleSection":"nbc-out","articleId":"rcna94989","identifier":{"@type":"PropertyValue","propertyID":"uid","value":"rcna94989"},"topics":"","image":{"@type":"ImageObject","url":"https://media-cldnry.s-nbcnews.com/image/upload/t_fit-1500w,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg","caption":""},"author":[{"@context":"https://schema.org/","@type":"Person","name":"Benjamin Ryan","image":"https://media-cldnry.s-nbcnews.com/image/upload/t_fit-1500w,f_auto,q_auto:best/newscms/2023_06/3593830/ben_ryan_headshot.jpg","jobTitle":null,"description":"Benjamin Ryan is independent journalist specializing in science and LGBTQ coverage. He contributes to NBC News, The New York Times, The Guardian and Thomson Reuters Foundation and has also written for The Washington Post, The Nation, The Atlantic and New York.","sameAs":["https://x.com/benryanwriter"]}],"publisher":{"@type":"NewsMediaOrganization","name":"NBC News","masthead":"https://www.nbcnews.com/news/us-news/nbc-news-digital-editors-n893846","url":"https://www.nbcnews.com","logo":{"@type":"ImageObject","url":"https://media-cldnry.s-nbcnews.com/image/upload/h_60/v1696280688/newsgroup-logos/nbcnews/logo/primary-black-424x45.png"},"sameAs":["https://x.com/nbcnews","https://www.pinterest.com/nbcnews/","https://www.facebook.com/NBCNews/","https://www.instagram.com/nbcnews/","https://www.youtube.com/nbcnews","https://www.snapchat.com/p/8bb879c7-45c0-499c-bb3c-7a3d0e229301/2193844248074240","https://www.tiktok.com/@nbcnews?lang=en"]},"description":"A man with HIV who underwent a stem cell transplant to treat blood cancer has been in remission for nearly two years, joining five others who are cured or possibly cured.","mainEntityOfPage":{"@type":"WebPage","@id":"https://www.nbcnews.com/nbc-out/out-health-and-wellness/hiv-remission-stem-cell-transplant-blood-cancer-rcna94989"},"keywords":"News"}</script><script type="application/ld+json">{"@context":{"@vocab":"http://schema.org","pageType":{"@id":"Text","@type":"@id"},"vertical":{"@id":"Text","@type":"@id"},"subVertical":{"@id":"Text","@type":"@id"},"section":{"@id":"Text","@type":"@id"},"subSection":{"@id":"Text","@type":"@id"},"label":{"@id":"Text","@type":"@id"},"packageId":{"@id":"Text","@type":"@id"},"sponsor":{"@id":"Text","@type":"@id"},"ecommerceEnabled":{"@id":"Text","@type":"@id"},"videoPlayerCount":{"@id":"Text","@type":"@id"},"appVersion":{"@id":"Text","@type":"@id"},"tags":{"@id":"Text","@type":"@id"},"gatedContentEnabled":{"@id":"Text","@type":"@id"}},"@type":"Dataset","name":"additionalTaxonomy","description":"This is additional taxonomy that helps us with 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class="article-hero__bg-container"><div class="article-hero__divider"></div><header class="article-hero__header mh0-print layout-grid-container"><aside class="article-hero__unibrow-grid layout-grid-item grid-col-2-l"><div data-testid="unibrow-container" class="unibrow articleTitleSection article-hero__tax-term"><a href="https://www.nbcnews.com/nbc-out/out-health-and-wellness/hiv-remission-stem-cell-transplant-blood-cancer-rcna94989"><span data-testid="unibrow-text">OUT Health and Wellness</span></a></div></aside><div class="article-hero-headline layout-grid-item grid-col-10-l"><h1 class="article-hero-headline__htag lh-none-print black-print">In remission from HIV, a sixth person could join the club of those possibly cured</h1><div class="styles_articleDek__Icz5H styles_withImage__SSIip" data-testid="article-dek">All received stem cell transplants to treat cancer, but — unlike the others — this man’s donor did not have a rare genetic resistance to HIV.</div></div></header></div><div class="article-hero__media-holder layout-grid-container"><div class="article-hero__media-container layout-grid-item grid-col-10-xl grid-col-push-2-xl"><figure class="article-hero__main"><picture class="article-hero__main-image" data-testid="picture"><source media="(min-width: 1000px)" srcSet="https://media-cldnry.s-nbcnews.com/image/upload/t_fit-1000w,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg"/><source media="(min-width: 758px)" srcSet="https://media-cldnry.s-nbcnews.com/image/upload/t_fit-760w,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg"/><source media="(min-width: 320px)" srcSet="https://media-cldnry.s-nbcnews.com/image/upload/t_fit-560w,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg"/><img src="https://media-cldnry.s-nbcnews.com/image/upload/t_fit-560w,f_auto,q_auto:best/rockcms/2023-07/230718-stem-cell-hiv-cure-se-602p-8e8a60.jpg" alt="Detailed Image of Stem Cell" height="1667" width="2500"/></picture></figure></div><figcaption class="caption article-hero__caption layout-grid-item grid-col-10-xl grid-col-push-2-xl" data-testid="caption"><span class="caption__container" data-testid="caption__container">A detailed image of a stem cell. </span><span class="caption__source" data-testid="caption__source">luismmolina / Getty Images</span></figcaption></div></section><div class="article-body" data-activity-map="article-article-body" data-taboola-target="read-more" data-testid="article-body"><div class="article-body__grid--container"><div class="ad dn-print" data-testid="ad__container"><div data-mps="true" data-slot="interstitial" data-sizes="[[[0,0],[[4,4]]]]" data-refresh-interval="0" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-testid="ad__container__inner"></div></div><div class="article-body__section"><div class="article-body layout-grid-item layout-grid-item--with-gutter-s-only grid-col-10-m grid-col-push-1-m 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z-1" dateTime="2023-07-19T23:03:15.860Z" data-testid="timestamp__datePublished" content="2023-07-19T23:03:15.860Z">July 19, 2023, 10:00 PM UTC<span> / </span>Updated July 19, 2023, 11:03 PM UTC</time></div><div class="article-body__byline"><div class="article-inline-byline" data-activity-map="inline-byline-article-top">By <span class="byline-name" data-testid="byline-name">Benjamin Ryan</span></div></div></section><div class="article-body__content"><p class="">A European man has been in a state of remission from HIV infection for nearly two years after receiving a stem cell transplant to treat blood cancer. If enough time passes with no signs of viable virus, he could join the rarefied club of five people who are considered either definitely or possibly cured of HIV.</p><p class="">All six people had HIV when they received stem cell transplants to treat blood cancers such as leukemia or lymphoma. But unlike the five other cases, this new one involves a person whose donor did not have a rare genetic abnormality that generates resistance to HIV in the immune cells that the virus targets for infection. </p><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><div id="taboolaReadMoreBelow"></div><p class="">The man’s case will be presented next week at the International AIDS Society Conference on HIV Science in Brisbane, Australia. This major biennial gathering of scientists will also hear noteworthy presentations regarding post-treatment control of HIV in infant boys, circumcision’s impact on HIV risk in gay men, and the relationship between HIV and mpox (formerly known as monkeypox). </p><p class="">It remains unethical for a person with HIV who does not already qualify for a stem cell transplant due to cancer to undergo such a treatment in hopes of curing the virus, given such treatment’s considerable toxicity. Scientists generally expect that any success in the effort to develop a widely scalable HIV cure therapy will likely take decades. </p><p class="">Nevertheless, Dr. Sharon Lewin, president of the IAS and director of the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, called the new viral remission case “great news.” Such case reports, she said, “help in many ways in the work toward a cure.” </p><h2 class=""><strong>The 'Geneva Patient'</strong> </h2><p class="">The man newly in remission from HIV has been dubbed the Geneva Patient, after the Swiss city where he has received his treatment. He is in his early 50s, was diagnosed with the virus in 1990 and began taking antiretroviral treatment in 2005. In 2018, he was diagnosed with a rare blood cancer known as an extramedullary myeloid tumor. He was treated with radiation, chemotherapy and a stem cell transplant.</p><div class="recommended-intersection-ref" data-activity-map="recommended-article-body-recommended" data-testid="recommended-wrapper"></div><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><p class="">His case has been overseen by a research team led by Asier Sáez-Cirión, head of the viral reservoirs and immune control unit at the Institut Pasteur in Paris. </p><p class="">HIV is vexingly difficult to cure. This is in large part because even when suppressed by antiretrovirals, the virus hides in nonreplicating immune cells, known collectively as the viral reservoir. Such standard HIV treatment only works on cells that are actively producing new viral copies. So the virus remains under the radar of antiretrovirals within these latently infected cells, each of which can take months or even years to return to a replicating state.</p><p class="">Since the first such case was<a href="https://www.nytimes.com/2008/11/14/health/14hiv.html"> announced</a> in 2008, <a href="https://www.nejm.org/doi/full/10.1056/nejmoa0802905">three </a>people have definitely been<a href="https://pubmed.ncbi.nlm.nih.gov/32169158/"> cured</a> and two additional people, pending more time passing without a viral rebound, <a href="https://pubmed.ncbi.nlm.nih.gov/36931242/">have</a> possibly<a href="https://www.cityofhope.org/patient-who-achieved-hiv-remission-shares-his-story"> been</a> cured <a href="https://www.nbcnews.com/feature/nbc-out/scientists-possibly-cured-hiv-woman-first-time-rcna16196">of HIV</a>.</p><p class="">Prior to the Geneva Patient’s case, a handful of other people with HIV who developed cancer also received stem cell transplants from donors without the rare genetic mutation conferring natural resistance to the virus. But none from this group went more than 10 months after stopping antiretroviral treatment without a resurgent virus. Hopes that they had been cured were dashed.</p><p class="">The man in Switzerland has now spent 20 months with no viral rebound, having been taken off of antiretrovirals in November 2021. Sáez-Cirión and his colleagues have conducted a battery of ultrasensitive tests in search of HIV in his body and have only been able to detect trace amounts of defective virus. But they still cannot rule out that the man retains even a single cell infected with viable virus, one that could spring to action at any moment and repopulate the body with HIV.</p><p class="">“The possibility of viral rebound is indeed a concern,” Sáez-Cirión said. “The virus may persist in rare infected blood cells or anatomical sites that we have not analyzed.”</p><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><p class="">It remains unclear why the Geneva Patient’s case has been so successful, at least thus far, while others who received similar treatment were not so fortunate.</p><div class="recommended-intersection-ref" data-activity-map="recommended-article-body-recommended" data-testid="recommended-wrapper"></div><p class="">Dr. Steven Deeks, a leading HIV cure researcher at the University of California, San Francisco, who was not involved in the study of the Geneva Patient, said the details of the case “suggest that what we once assumed was impossible might in fact be possible.” </p><p class="">Speculating about the drivers of this man’s lengthy HIV remission, Deeks said, “Eliminating most if not all of the reservoir with chemotherapy was certainly the key intervention.” Deeks also noted the man’s repeated episodes of what is known as graft-versus-host disease, a powerful and potentially dangerous immune reaction that occurs as a consequence of a stem cell transplant. This might have also played a crucial role, Deeks said, “as the newly rebuilt immune system may have been attacking and clearing the old immune system, including any residual T cells harboring HIV.”</p><p class="">Sáez-Cirión said it is also possible that the immunosuppressive drugs that the Geneva Patient continues to receive to prevent graft-versus-host disease may be preventing any residual HIV from replicating.</p><h2 class=""><strong>Post-treatment control of HIV</strong> </h2><p class="">Researchers in sub-Saharan Africa have identified a handful of boys born with HIV who did not experience viral rebound even after their antiretroviral treatment was interrupted for extended periods. </p><p class="">This finding comes from a study of 281 mothers in South Africa who had passed HIV to their newborns. The infants were all put on antiretrovirals immediately after birth. But the investigators eventually discovered that the caretakers of five boys had not provided them with HIV treatment for periods spanning three to 10 months, and yet each of these children maintained an undetectable or very low viral load. </p><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><p class="">Four of the boys were immediately put back on HIV treatment. However, one other has been kept off of treatment and has now passed 19 months without a viral rebound. Three of the others have been enrolled in a study in which their treatment will once again be interrupted, but under close monitoring. </p><p class="">Dr. Gabriela Cromhout, a research clinician and doctoral candidate at the University of KwaZulu-Natal and one of the lead authors of the study, said three of the boys can be classified as so-called post-treatment controllers of HIV, because they had sustained an undetectable viral load for more than six months while off antiretrovirals.</p><p class="">In advance of their conference presentation, Cromhout and her colleagues did not, however, conduct any ultrasensitive tests to search for the residual presence of HIV in the children’s bodies. Such tests are ongoing.</p><p class="">Dr. Deborah Persaud, a pediatric infectious disease specialist at the Johns Hopkins University School of Medicine and the head of a major ongoing study seeking to cure HIV in infants, said, “This is an enormous advance for the field of HIV remission and cure.” However, Persaud, who was not involved in the South African study, said to back their findings, the study’s investigators would need to present data at the conference confirming that the five boys were infected and that they were indeed off antiretrovirals for the extended periods — data that Cromhout confirmed her team has on hand.</p><h2 class=""><strong>Circumcision and HIV risk</strong> </h2><p class="">In the mid-2000s, a <a href="https://pubmed.ncbi.nlm.nih.gov/17321310/">trio</a> of <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60313-4/fulltext">randomized</a> controlled <a href="https://journals.plos.org/plosmedicine/article/info:doi/10.1371/journal.pmed.0020298">trials</a> in sub-Saharan Africa determined that circumcising men reduced the risk of female-to-male sexual transmission of HIV by about 50% to 60%.</p><p class="">Now, a research team in China is the first to have completed such a study of gay and bisexual men. They enrolled about 250 uncircumcised men who have sex with men who reported primarily being the insertive partner in intercourse (known as being the “top”). Half were randomly selected to be circumcised. After one year, five study participants contracted HIV, all of them in the control group. The study registered no significant differences in sexual behaviors between the two study groups that might have affected the men’s relative risk of HIV. </p><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><p class="">The difference in the HIV acquisition rate between the two study groups, the investigators calculated, was statistically significant.</p><p class="">On a media call Wednesday, Dr. Huachun Zou, a professor of epidemiology at the Sun Yat-sen University School of Public Health in Shenzhen, China, said larger studies may be necessary to fully establish whether circumcision reduces the risk of HIV among gay and bisexual men. But he said it is “very unlikely” that researchers will, indeed, launch such research because of the global popularity of the HIV prevention pill, known as PrEP, as a means of reducing risk of the virus among gay and bi men. He said PrEP is not, however, widely used in China, a nation that also has a low circumcision rate. </p><h2 class=""><strong>HIV and mpox hospitalization</strong></h2><p class="">This study looked at surveillance data from the World Health Organization regarding 82,290 mpox cases from 2022. There was information about the HIV status for 39% of these people, among whom 52% — 16,633 people, or 20% of the total — had that virus.</p><p class="">The study found that overall, having HIV was not associated with a greater likelihood of being hospitalized with mpox. However, being immunocompromised, including from HIV or from another factor, was tied to about two to four times the hospitalization risk, compared with being HIV-negative and having a healthy immune system.</p><p class="">Fifty-eight of the people with HIV died, as did four of the 15,371 people without HIV. </p><p class="">A paper <a href="https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00273-8/fulltext">published in The Lancet</a> in February found that people with HIV<a href="https://www.nbcnews.com/nbc-out/out-health-and-wellness/mpox-highly-fatal-people-advanced-hiv-study-finds-rcna71599"> had a very high risk of death</a> from mpox if their immune system was suppressed.</p><div class="ad ad--text-alignment ad-container boxinlineAd dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxinline" data-sizes="[[[1000,1],[]],[[758,1],[[300,250],[700,50],[5,5],[728,90],[360,360]]],[[0,0],[[300,250],[700,50],[5,5],[360,360]]]]" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-offset-viewport="100" data-testid="ad__container__inner"></div></div><p class="endmark">People with HIV who are treated with antiretrovirals can maintain essentially healthy immune systems.</p></div><div class="article-body__content"><div class="expanded-byline-contributors articleBylineContainer"><div class="expanded-byline article-expanded-byline" data-activity-map="expanded-byline-article-bottom"><div class="byline-thumbnail byline-thumbnail--has-image expanded-byline__thumbnail" data-testid="byline-thumbnail"><picture data-testid="picture"><source media="(min-width: 320px)" srcSet="https://media-cldnry.s-nbcnews.com/image/upload/t_focal-60x60,f_avif,q_auto:eco,dpr_2/newscms/2023_06/3593830/ben_ryan_headshot.jpg 2x, https://media-cldnry.s-nbcnews.com/image/upload/t_focal-60x60,f_auto,q_auto:best/newscms/2023_06/3593830/ben_ryan_headshot.jpg 1x"/><img loading="lazy" src="https://media-cldnry.s-nbcnews.com/image/upload/t_focal-60x60,f_auto,q_auto:best/newscms/2023_06/3593830/ben_ryan_headshot.jpg" alt="" height="48" width="48"/></picture></div><span class="byline-name expanded-byline__name" data-testid="byline-name">Benjamin Ryan</span><span class="byline-social expanded-byline__social"><a href="https://x.com/benryanwriter" target="_blank" rel="noopener noreferrer" class="byline-social--link"><span class="icon icon-twitter"></span></a></span><div class="expanded-byline__bio-wrapper"><p class="byline-bio expanded-byline__bio">Benjamin Ryan is independent journalist specializing in science and LGBTQ coverage. He contributes to NBC News, The New York Times, The Guardian and Thomson Reuters Foundation and has also written for The Washington Post, The Nation, The Atlantic and New York.</p></div></div></div></div></div><div class="article-body--right-rail-container"><div data-testid="right-rail-container" class="article-body__right-rail layout-grid-item grid-col-4_5-l grid-col-3_5-xl grid-col-push-half-xl"><div class="article-body__right-rail--sticky"></div><div class="ad article-body__right-rail--ad ad--text-alignment ad-container dn-print" data-testid="ad__container"><div data-mps="true" data-slot="boxrail" data-sizes="[[[1000,1],[[300,250],[360,360]]],[[758,1],[]],[[0,0],[]]]" data-offset="10" data-render-on-view="true" data-targeting="{}" data-active-tab="true" data-testid="ad__container__inner"></div></div></div></div></div><div class="body-bottom-recommended" data-testid="body-bottom-recommended"><div class="ad ad--midresponsive ad-container dn-print" data-testid="ad__container"><div 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received stem cell transplants to treat cancer, but — unlike the others — this man’s donor did not have a rare genetic resistance to HIV.","content":{"text":["A European man has been in a state of remission from HIV infection for nearly two years after receiving a stem cell transplant to treat blood cancer. If enough time passes with no signs of viable virus, he could join the rarefied club of five people who are considered either definitely or possibly cured of HIV.","All six people had HIV when they received stem cell transplants to treat blood cancers such as leukemia or lymphoma. But unlike the five other cases, this new one involves a person whose donor did not have a rare genetic abnormality that generates resistance to HIV in the immune cells that the virus targets for infection. ","The man’s case will be presented next week at the International AIDS Society Conference on HIV Science in Brisbane, Australia. This major biennial gathering of scientists will also hear noteworthy presentations regarding post-treatment control of HIV in infant boys, circumcision’s impact on HIV risk in gay men, and the relationship between HIV and mpox (formerly known as monkeypox). ","It remains unethical for a person with HIV who does not already qualify for a stem cell transplant due to cancer to undergo such a treatment in hopes of curing the virus, given such treatment’s considerable toxicity. Scientists generally expect that any success in the effort to develop a widely scalable HIV cure therapy will likely take decades. ","Nevertheless, Dr. Sharon Lewin, president of the IAS and director of the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, called the new viral remission case “great news.” Such case reports, she said, “help in many ways in the work toward a cure.” ","The 'Geneva Patient' ","The man newly in remission from HIV has been dubbed the Geneva Patient, after the Swiss city where he has received his treatment. He is in his early 50s, was diagnosed with the virus in 1990 and began taking antiretroviral treatment in 2005. In 2018, he was diagnosed with a rare blood cancer known as an extramedullary myeloid tumor. He was treated with radiation, chemotherapy and a stem cell transplant.","His case has been overseen by a research team led by Asier Sáez-Cirión, head of the viral reservoirs and immune control unit at the Institut Pasteur in Paris. ","HIV is vexingly difficult to cure. This is in large part because even when suppressed by antiretrovirals, the virus hides in nonreplicating immune cells, known collectively as the viral reservoir. Such standard HIV treatment only works on cells that are actively producing new viral copies. So the virus remains under the radar of antiretrovirals within these latently infected cells, each of which can take months or even years to return to a replicating state.","Since the first such case was announced in 2008, three people have definitely been cured and two additional people, pending more time passing without a viral rebound, have possibly been cured of HIV.","Prior to the Geneva Patient’s case, a handful of other people with HIV who developed cancer also received stem cell transplants from donors without the rare genetic mutation conferring natural resistance to the virus. But none from this group went more than 10 months after stopping antiretroviral treatment without a resurgent virus. Hopes that they had been cured were dashed.","The man in Switzerland has now spent 20 months with no viral rebound, having been taken off of antiretrovirals in November 2021. Sáez-Cirión and his colleagues have conducted a battery of ultrasensitive tests in search of HIV in his body and have only been able to detect trace amounts of defective virus. But they still cannot rule out that the man retains even a single cell infected with viable virus, one that could spring to action at any moment and repopulate the body with HIV.","“The possibility of viral rebound is indeed a concern,” Sáez-Cirión said. “The virus may persist in rare infected blood cells or anatomical sites that we have not analyzed.”","It remains unclear why the Geneva Patient’s case has been so successful, at least thus far, while others who received similar treatment were not so fortunate.","Dr. Steven Deeks, a leading HIV cure researcher at the University of California, San Francisco, who was not involved in the study of the Geneva Patient, said the details of the case “suggest that what we once assumed was impossible might in fact be possible.” ","Speculating about the drivers of this man’s lengthy HIV remission, Deeks said, “Eliminating most if not all of the reservoir with chemotherapy was certainly the key intervention.” Deeks also noted the man’s repeated episodes of what is known as graft-versus-host disease, a powerful and potentially dangerous immune reaction that occurs as a consequence of a stem cell transplant. This might have also played a crucial role, Deeks said, “as the newly rebuilt immune system may have been attacking and clearing the old immune system, including any residual T cells harboring HIV.”","Sáez-Cirión said it is also possible that the immunosuppressive drugs that the Geneva Patient continues to receive to prevent graft-versus-host disease may be preventing any residual HIV from replicating.","Post-treatment control of HIV ","Researchers in sub-Saharan Africa have identified a handful of boys born with HIV who did not experience viral rebound even after their antiretroviral treatment was interrupted for extended periods. ","This finding comes from a study of 281 mothers in South Africa who had passed HIV to their newborns. The infants were all put on antiretrovirals immediately after birth. But the investigators eventually discovered that the caretakers of five boys had not provided them with HIV treatment for periods spanning three to 10 months, and yet each of these children maintained an undetectable or very low viral load. ","Four of the boys were immediately put back on HIV treatment. However, one other has been kept off of treatment and has now passed 19 months without a viral rebound. Three of the others have been enrolled in a study in which their treatment will once again be interrupted, but under close monitoring. ","Dr. Gabriela Cromhout, a research clinician and doctoral candidate at the University of KwaZulu-Natal and one of the lead authors of the study, said three of the boys can be classified as so-called post-treatment controllers of HIV, because they had sustained an undetectable viral load for more than six months while off antiretrovirals.","In advance of their conference presentation, Cromhout and her colleagues did not, however, conduct any ultrasensitive tests to search for the residual presence of HIV in the children’s bodies. Such tests are ongoing.","Dr. Deborah Persaud, a pediatric infectious disease specialist at the Johns Hopkins University School of Medicine and the head of a major ongoing study seeking to cure HIV in infants, said, “This is an enormous advance for the field of HIV remission and cure.” However, Persaud, who was not involved in the South African study, said to back their findings, the study’s investigators would need to present data at the conference confirming that the five boys were infected and that they were indeed off antiretrovirals for the extended periods — data that Cromhout confirmed her team has on hand.","Circumcision and HIV risk ","In the mid-2000s, a trio of randomized controlled trials in sub-Saharan Africa determined that circumcising men reduced the risk of female-to-male sexual transmission of HIV by about 50% to 60%.","Now, a research team in China is the first to have completed such a study of gay and bisexual men. They enrolled about 250 uncircumcised men who have sex with men who reported primarily being the insertive partner in intercourse (known as being the “top”). Half were randomly selected to be circumcised. After one year, five study participants contracted HIV, all of them in the control group. The study registered no significant differences in sexual behaviors between the two study groups that might have affected the men’s relative risk of HIV. ","The difference in the HIV acquisition rate between the two study groups, the investigators calculated, was statistically significant.","On a media call Wednesday, Dr. Huachun Zou, a professor of epidemiology at the Sun Yat-sen University School of Public Health in Shenzhen, China, said larger studies may be necessary to fully establish whether circumcision reduces the risk of HIV among gay and bisexual men. But he said it is “very unlikely” that researchers will, indeed, launch such research because of the global popularity of the HIV prevention pill, known as PrEP, as a means of reducing risk of the virus among gay and bi men. He said PrEP is not, however, widely used in China, a nation that also has a low circumcision rate. ","HIV and mpox hospitalization","This study looked at surveillance data from the World Health Organization regarding 82,290 mpox cases from 2022. There was information about the HIV status for 39% of these people, among whom 52% — 16,633 people, or 20% of the total — had that virus.","The study found that overall, having HIV was not associated with a greater likelihood of being hospitalized with mpox. However, being immunocompromised, including from HIV or from another factor, was tied to about two to four times the hospitalization risk, compared with being HIV-negative and having a healthy immune system.","Fifty-eight of the people with HIV died, as did four of the 15,371 people without HIV. ","A paper published in The Lancet in February found that people with HIV had a very high risk of death from mpox if their immune system was suppressed.","People with HIV who are treated with antiretrovirals can maintain essentially healthy immune systems."]},"documentTracing":{"currentMessageId":{"id":"e077a82f-11b8-406f-8a09-0b7580a04cb9","updatedDate":"Thu Jul 20 2023 03:32:43 GMT+0000 (UTC)"},"correlationID":"a1815116-baca-47a9-b71e-2983f738e884","type":"article"},"flag":null,"unibrow":{"logo":null,"taxonomyPath":"nbcnews/feature/nbc-out/out-health-and-wellness","text":"OUT Health and Wellness","url":{"primary":"https://www.nbcnews.com/nbc-out/out-health-and-wellness/hiv-remission-stem-cell-transplant-blood-cancer-rcna94989"}},"primaryMedia":{"presentation":{"alignment":"left","size":"medium","style":"default","byline":null,"hideRecommendations":false,"hideProductRecommendations":false},"type":"embeddedImage","image":{"id":"rcim155993","headline":{"primary":null,"tease":null,"seo":null,"social":null},"caption":"A detailed image of a stem cell. 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He contributes to NBC News, The New York Times, The Guardian and Thomson Reuters Foundation and has also written for The Washington Post, The Nation, The Atlantic and New York.","elementId":null}],"dateCreated":"Mon Feb 22 2021 21:48:53 GMT+0000 (UTC)","dateModified":"Wed Feb 22 2023 02:14:39 GMT+0000 (UTC)","shortBio":null,"liveBlogShortBio":"","experience":[],"educationAndExpertise":[],"awards":[],"id":"ncpn1258561","email":null,"jobTitle":[],"name":"Benjamin Ryan","primaryImage":{"altText":null,"height":857,"url":{"primary":"https://media-cldnry.s-nbcnews.com/image/upload/newscms/2023_06/3593830/ben_ryan_headshot.jpg"},"width":1200},"publisher":{"name":"nbcnews","subType":null,"type":"organization"},"socialMediaProfiles":{"email":null,"facebook":null,"instagram":null,"pinterest":null,"snapchat":null,"tiktok":null,"twitter":"@benryanwriter","whatsapp":null,"youtube":null,"mastodon":null,"threads":null,"signal":null},"subType":null,"type":"person","url":null,"worksFor":null,"content":{"pagination":{"offset":0,"page":1,"size":3,"totalItems":3,"totalPages":1},"items":[{"id":"ncna1275737","url":{"primary":"https://www.nbcnews.com/health/health-news/fda-authorizes-covid-antibody-treatment-preventive-after-exposure-n1275737"},"vertical":"news","datePublished":"Tue Aug 03 2021 13:40:00 GMT+0000 (UTC)","headline":{"primary":"FDA authorizes Covid antibody treatment as preventive after exposure"},"unibrow":{"logo":null,"taxonomyPath":"nbcnews/section/health/health-news","text":"Health news","url":{"primary":"https://www.nbcnews.com/health"}},"description":{"primary":"The unvaccinated or people with weak immune systems at high risk of severe disease can receive an injection if exposed to an infected person."},"teaseImage":{"altText":"Image: Regeneron","height":1667,"url":{"primary":"https://media-cldnry.s-nbcnews.com/image/upload/newscms/2021_31/3418471/201008-regeneron-al-0925.jpg"},"width":2500},"primaryImage":null},{"id":"ncna1274887","url":{"primary":"https://www.nbcnews.com/health/health-news/long-acting-hiv-prevention-drugs-may-be-key-beating-epidemic-n1274887"},"vertical":"news","datePublished":"Wed Jul 28 2021 09:00:00 GMT+0000 (UTC)","headline":{"primary":"Long-acting HIV-prevention drugs may be key to beating the epidemic in the U.S. "},"unibrow":{"logo":null,"taxonomyPath":"nbcnews/section/health/health-news","text":"Health news","url":{"primary":"https://www.nbcnews.com/health"}},"description":{"primary":"New forms of pre-exposure prophylaxis, or PrEP, could be used by groups who find daily preventive medications too burdensome."},"teaseImage":{"altText":"The HIV drug Cabenuva.","height":1250,"url":{"primary":"https://media-cldnry.s-nbcnews.com/image/upload/newscms/2021_30/3494749/210723-silo-cabenuva-mb-2121.jpg"},"width":2500},"primaryImage":null},{"id":"ncna1258556","url":{"primary":"https://www.nbcnews.com/feature/nbc-out/meth-has-devastated-gay-community-decades-new-treatment-offers-hope-n1258556"},"vertical":"news","datePublished":"Tue Feb 23 2021 12:56:00 GMT+0000 (UTC)","headline":{"primary":"Meth has devastated the gay community for decades. A new treatment offers hope."},"unibrow":{"logo":null,"taxonomyPath":"nbcnews/feature/nbc-out/out-health-and-wellness","text":"OUT Health and Wellness","url":{"primary":"https://www.nbcnews.com/feature/nbc-out/meth-has-devastated-gay-community-decades-new-treatment-offers-hope-n1258556"}},"description":{"primary":"The promising medication-based treatment comes as meth's use is surging in the general population and dangerously merging with the opioid crisis."},"teaseImage":{"altText":"Image: Silhouette of a man with smoke coming from his mouth","height":1558,"url":{"primary":"https://media-cldnry.s-nbcnews.com/image/upload/newscms/2021_08/3451799/210222-smoking-bw-stock-cs.jpg"},"width":2500},"primaryImage":null}]}}}],"adsEnabled":true,"ecommerceEnabled":false,"sponsoredBy":null,"hidden":false,"searchable":true,"nativeAd":false,"breakingNews":false,"breakingTagDisabled":true,"body":[{"type":"markup","element":"p","html":"A European man has been in a state of remission from HIV infection for nearly two years after receiving a stem cell transplant to treat blood cancer. If enough time passes with no signs of viable virus, he could join the rarefied club of five people who are considered either definitely or possibly cured of HIV.","elementId":null},{"type":"markup","element":"p","html":"All six people had HIV when they received stem cell transplants to treat blood cancers such as leukemia or lymphoma. But unlike the five other cases, this new one involves a person whose donor did not have a rare genetic abnormality that generates resistance to HIV in the immune cells that the virus targets for infection. ","elementId":null},{"type":"markup","element":"p","html":"The man’s case will be presented next week at the International AIDS Society Conference on HIV Science in Brisbane, Australia. This major biennial gathering of scientists will also hear noteworthy presentations regarding post-treatment control of HIV in infant boys, circumcision’s impact on HIV risk in gay men, and the relationship between HIV and mpox (formerly known as monkeypox). ","elementId":null},{"type":"markup","element":"p","html":"It remains unethical for a person with HIV who does not already qualify for a stem cell transplant due to cancer to undergo such a treatment in hopes of curing the virus, given such treatment’s considerable toxicity. Scientists generally expect that any success in the effort to develop a widely scalable HIV cure therapy will likely take decades. ","elementId":null},{"type":"markup","element":"p","html":"Nevertheless, Dr. Sharon Lewin, president of the IAS and director of the Peter Doherty Institute for Infection and Immunity in Melbourne, Australia, called the new viral remission case “great news.” Such case reports, she said, “help in many ways in the work toward a cure.” ","elementId":null},{"type":"markup","element":"h2","html":"\u003cstrong\u003eThe 'Geneva Patient'\u003c/strong\u003e ","elementId":null},{"type":"markup","element":"p","html":"The man newly in remission from HIV has been dubbed the Geneva Patient, after the Swiss city where he has received his treatment. He is in his early 50s, was diagnosed with the virus in 1990 and began taking antiretroviral treatment in 2005. In 2018, he was diagnosed with a rare blood cancer known as an extramedullary myeloid tumor. He was treated with radiation, chemotherapy and a stem cell transplant.","elementId":null},{"type":"markup","element":"p","html":"His case has been overseen by a research team led by Asier Sáez-Cirión, head of the viral reservoirs and immune control unit at the Institut Pasteur in Paris. ","elementId":null},{"type":"markup","element":"p","html":"HIV is vexingly difficult to cure. This is in large part because even when suppressed by antiretrovirals, the virus hides in nonreplicating immune cells, known collectively as the viral reservoir. Such standard HIV treatment only works on cells that are actively producing new viral copies. So the virus remains under the radar of antiretrovirals within these latently infected cells, each of which can take months or even years to return to a replicating state.","elementId":null},{"type":"markup","element":"p","html":"Since the first such case was\u003ca href=\"https://www.nytimes.com/2008/11/14/health/14hiv.html\"\u003e announced\u003c/a\u003e in 2008, \u003ca href=\"https://www.nejm.org/doi/full/10.1056/nejmoa0802905\"\u003ethree \u003c/a\u003epeople have definitely been\u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/32169158/\"\u003e cured\u003c/a\u003e and two additional people, pending more time passing without a viral rebound, \u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/36931242/\"\u003ehave\u003c/a\u003e possibly\u003ca href=\"https://www.cityofhope.org/patient-who-achieved-hiv-remission-shares-his-story\"\u003e been\u003c/a\u003e cured \u003ca href=\"https://www.nbcnews.com/feature/nbc-out/scientists-possibly-cured-hiv-woman-first-time-rcna16196\"\u003eof HIV\u003c/a\u003e.","elementId":null},{"type":"markup","element":"p","html":"Prior to the Geneva Patient’s case, a handful of other people with HIV who developed cancer also received stem cell transplants from donors without the rare genetic mutation conferring natural resistance to the virus. But none from this group went more than 10 months after stopping antiretroviral treatment without a resurgent virus. Hopes that they had been cured were dashed.","elementId":null},{"type":"markup","element":"p","html":"The man in Switzerland has now spent 20 months with no viral rebound, having been taken off of antiretrovirals in November 2021. Sáez-Cirión and his colleagues have conducted a battery of ultrasensitive tests in search of HIV in his body and have only been able to detect trace amounts of defective virus. But they still cannot rule out that the man retains even a single cell infected with viable virus, one that could spring to action at any moment and repopulate the body with HIV.","elementId":null},{"type":"markup","element":"p","html":"“The possibility of viral rebound is indeed a concern,” Sáez-Cirión said. “The virus may persist in rare infected blood cells or anatomical sites that we have not analyzed.”","elementId":null},{"type":"markup","element":"p","html":"It remains unclear why the Geneva Patient’s case has been so successful, at least thus far, while others who received similar treatment were not so fortunate.","elementId":null},{"type":"markup","element":"p","html":"Dr. Steven Deeks, a leading HIV cure researcher at the University of California, San Francisco, who was not involved in the study of the Geneva Patient, said the details of the case “suggest that what we once assumed was impossible might in fact be possible.” ","elementId":null},{"type":"markup","element":"p","html":"Speculating about the drivers of this man’s lengthy HIV remission, Deeks said, “Eliminating most if not all of the reservoir with chemotherapy was certainly the key intervention.” Deeks also noted the man’s repeated episodes of what is known as graft-versus-host disease, a powerful and potentially dangerous immune reaction that occurs as a consequence of a stem cell transplant. This might have also played a crucial role, Deeks said, “as the newly rebuilt immune system may have been attacking and clearing the old immune system, including any residual T cells harboring HIV.”","elementId":null},{"type":"markup","element":"p","html":"Sáez-Cirión said it is also possible that the immunosuppressive drugs that the Geneva Patient continues to receive to prevent graft-versus-host disease may be preventing any residual HIV from replicating.","elementId":null},{"type":"markup","element":"h2","html":"\u003cstrong\u003ePost-treatment control of HIV\u003c/strong\u003e ","elementId":null},{"type":"markup","element":"p","html":"Researchers in sub-Saharan Africa have identified a handful of boys born with HIV who did not experience viral rebound even after their antiretroviral treatment was interrupted for extended periods. ","elementId":null},{"type":"markup","element":"p","html":"This finding comes from a study of 281 mothers in South Africa who had passed HIV to their newborns. The infants were all put on antiretrovirals immediately after birth. But the investigators eventually discovered that the caretakers of five boys had not provided them with HIV treatment for periods spanning three to 10 months, and yet each of these children maintained an undetectable or very low viral load. ","elementId":null},{"type":"markup","element":"p","html":"Four of the boys were immediately put back on HIV treatment. However, one other has been kept off of treatment and has now passed 19 months without a viral rebound. Three of the others have been enrolled in a study in which their treatment will once again be interrupted, but under close monitoring. ","elementId":null},{"type":"markup","element":"p","html":"Dr. Gabriela Cromhout, a research clinician and doctoral candidate at the University of KwaZulu-Natal and one of the lead authors of the study, said three of the boys can be classified as so-called post-treatment controllers of HIV, because they had sustained an undetectable viral load for more than six months while off antiretrovirals.","elementId":null},{"type":"markup","element":"p","html":"In advance of their conference presentation, Cromhout and her colleagues did not, however, conduct any ultrasensitive tests to search for the residual presence of HIV in the children’s bodies. Such tests are ongoing.","elementId":null},{"type":"markup","element":"p","html":"Dr. Deborah Persaud, a pediatric infectious disease specialist at the Johns Hopkins University School of Medicine and the head of a major ongoing study seeking to cure HIV in infants, said, “This is an enormous advance for the field of HIV remission and cure.” However, Persaud, who was not involved in the South African study, said to back their findings, the study’s investigators would need to present data at the conference confirming that the five boys were infected and that they were indeed off antiretrovirals for the extended periods — data that Cromhout confirmed her team has on hand.","elementId":null},{"type":"markup","element":"h2","html":"\u003cstrong\u003eCircumcision and HIV risk\u003c/strong\u003e ","elementId":null},{"type":"markup","element":"p","html":"In the mid-2000s, a \u003ca href=\"https://pubmed.ncbi.nlm.nih.gov/17321310/\"\u003etrio\u003c/a\u003e of \u003ca href=\"https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(07)60313-4/fulltext\"\u003erandomized\u003c/a\u003e controlled \u003ca href=\"https://journals.plos.org/plosmedicine/article/info:doi/10.1371/journal.pmed.0020298\"\u003etrials\u003c/a\u003e in sub-Saharan Africa determined that circumcising men reduced the risk of female-to-male sexual transmission of HIV by about 50% to 60%.","elementId":null},{"type":"markup","element":"p","html":"Now, a research team in China is the first to have completed such a study of gay and bisexual men. They enrolled about 250 uncircumcised men who have sex with men who reported primarily being the insertive partner in intercourse (known as being the “top”). Half were randomly selected to be circumcised. After one year, five study participants contracted HIV, all of them in the control group. The study registered no significant differences in sexual behaviors between the two study groups that might have affected the men’s relative risk of HIV. ","elementId":null},{"type":"markup","element":"p","html":"The difference in the HIV acquisition rate between the two study groups, the investigators calculated, was statistically significant.","elementId":null},{"type":"markup","element":"p","html":"On a media call Wednesday, Dr. Huachun Zou, a professor of epidemiology at the Sun Yat-sen University School of Public Health in Shenzhen, China, said larger studies may be necessary to fully establish whether circumcision reduces the risk of HIV among gay and bisexual men. But he said it is “very unlikely” that researchers will, indeed, launch such research because of the global popularity of the HIV prevention pill, known as PrEP, as a means of reducing risk of the virus among gay and bi men. He said PrEP is not, however, widely used in China, a nation that also has a low circumcision rate. ","elementId":null},{"type":"markup","element":"h2","html":"\u003cstrong\u003eHIV and mpox hospitalization\u003c/strong\u003e","elementId":null},{"type":"markup","element":"p","html":"This study looked at surveillance data from the World Health Organization regarding 82,290 mpox cases from 2022. There was information about the HIV status for 39% of these people, among whom 52% — 16,633 people, or 20% of the total — had that virus.","elementId":null},{"type":"markup","element":"p","html":"The study found that overall, having HIV was not associated with a greater likelihood of being hospitalized with mpox. However, being immunocompromised, including from HIV or from another factor, was tied to about two to four times the hospitalization risk, compared with being HIV-negative and having a healthy immune system.","elementId":null},{"type":"markup","element":"p","html":"Fifty-eight of the people with HIV died, as did four of the 15,371 people without HIV. ","elementId":null},{"type":"markup","element":"p","html":"A paper \u003ca href=\"https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(23)00273-8/fulltext\"\u003epublished in The Lancet\u003c/a\u003e in February found that people with HIV\u003ca href=\"https://www.nbcnews.com/nbc-out/out-health-and-wellness/mpox-highly-fatal-people-advanced-hiv-study-finds-rcna71599\"\u003e had a very high risk of death\u003c/a\u003e from mpox if their immune system was suppressed.","elementId":null},{"type":"markup","element":"p","html":"People with HIV who are treated with antiretrovirals can maintain essentially healthy immune systems.","elementId":null}],"datePublished":"Wed Jul 19 2023 23:03:15 GMT+0000 (UTC)","dateModified":"Thu Jul 20 2023 03:32:43 GMT+0000 (UTC)","dateCreated":"Wed Jul 19 2023 22:00:40 GMT+0000 (UTC)","source":null,"presentation":{"alignment":"left","size":"medium","style":"default","byline":"EXPANDED","hideRecommendations":false,"hideProductRecommendations":false},"publisher":{"name":"nbcnews"},"subnav":null,"eventDateTime":{"endsAt":null}}],"error":null,"isNativeAd":false,"presentation":{"alignment":"left","size":"medium","style":"default","byline":"EXPANDED","hideRecommendations":false,"hideProductRecommendations":false},"fetchingRelated":false,"relatedArticles":null,"isLoadingMostPopularStories":false,"mostPopularStoryList":{"callout":null,"content":{"pagination":{"totalItems":10},"items":[{"headline":{"tease":"Matt Gaetz says he doesn't plan to rejoin Congress after withdrawing as Trump's pick for attorney general"},"id":"rcna181378","url":{"primary":"https://www.nbcnews.com/politics/congress/matt-gaetz-says-doesnt-plan-rejoin-congress-withdrawing-name-attorney-rcna181378"}},{"headline":{"tease":"With Matt Gaetz's withdrawal, Trump's 'retribution' campaign hits the harsh reality of governing in Washington"},"id":"rcna181233","url":{"primary":"https://www.nbcnews.com/politics/donald-trump/matt-gaetzs-withdrawal-trumps-retribution-campaign-rcna181233"}},{"headline":{"tease":"Texas Board of Education votes to approve Bible curriculum in elementary schools"},"id":"rcna181415","url":{"primary":"https://www.nbcnews.com/news/us-news/texas-board-education-votes-approve-bible-curriculum-elementary-school-rcna181415"}},{"headline":{"tease":"Trump's transition team turns to Project 2025 after disavowing it during the campaign"},"id":"rcna180689","url":{"primary":"https://www.nbcnews.com/politics/donald-trump/trump-team-turns-project-2025-disavowing-effort-campaign-rcna180689"}},{"headline":{"tease":"Kansas woman found buried in a freezer in Oklahoma died from 30 stab wounds, report says"},"id":"rcna181260","url":{"primary":"https://www.nbcnews.com/news/us-news/kansas-woman-found-buried-freezer-oklahoma-died-30-stab-wounds-report-rcna181260"}},{"headline":{"tease":"Putin claims new missile used in Ukraine is 'incapable' of being intercepted"},"id":"rcna181304","url":{"primary":"https://www.nbcnews.com/news/world/putin-kim-threats-keep-pressure-kyiv-week-escalations-rcna181304"}},{"headline":{"tease":"Giants release struggling quarterback Daniel Jones after signing him to $160 million deal "},"id":"rcna181374","url":{"primary":"https://www.nbcnews.com/sports/nfl/giants-release-daniel-jones-rcna181374"}},{"headline":{"tease":"Israel kills Hezbollah leader who planned elaborate attack on U.S. soldiers in Iraq"},"id":"rcna181315","url":{"primary":"https://www.nbcnews.com/politics/israel-kills-hezbollah-leader-planned-elaborate-attack-us-soldiers-ira-rcna181315"}},{"headline":{"tease":"Vaccines don't cause autism. 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