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class="frame-backgroundimage-container"><div id="frame-backgroundimage-21404" class="frame-backgroundimage"><div class="copyright">漏 James Steidl und Sebastian Kaulitzki / fotolia.com</div></div></div></div></div><div class="frame-type-intro"><div class="frame-container frame-container-default"><div class="frame-inner"><header class="frame-header"><h1 class="element-header mb-2"><span>Oligodendrozyten in demyelinisierenden Erkrankungen</span></h1></header></div></div></div></div><nav class="breadcrumb-section" aria-label="Brotkr眉melnavigation"><div class="container"><p class="sr-only" id="breadcrumb">Sie sind hier:</p><ol class="breadcrumb"><li class="breadcrumb-item"><a class="breadcrumb-link" href="https://www.uk-erlangen.de/" title="Zur Startseite des Universit盲tsklinikums Erlangen"><svg height="37" xmlns="http://www.w3.org/2000/svg" viewBox="0,0,63,64"><g><path d="M20.937+21.0438L0+21.0438L0+42.3789L20.937+42.3789L20.937+21.0438Z" opacity="1" fill="#00a579"/><path 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class="breadcrumb-text">Grundlagenforschung</span></a></li><li class="breadcrumb-item icon-arrow_right active" aria-current="page"><span class="breadcrumb-text">Oligodendrozyten in demyelinisierenden Erkrankungen</span></li></ol></div></nav><main id="page-content" class="bp-page-content main-section"><div class="section section-before-content"></div><div class="section section-default"><div id="c67283" class=" frame frame-default frame-type-text frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="frame-header"><h2 class="element-header "><span>Oligodendrozyten in demyelinisierenden Erkrankungen</span></h2><h3 class="element-subheader "><span>Projektleitung / Mitarbeiter: Prof. Dr. J眉rgen Winkler / Dr. Alana Hoffmann/ Dr. Jeanette Wihan/ M. Sc. Kristina Battis/ Lisa M茅sz谩ros</span></h3></div><p>In der Multisystematrophie (MSA), einem atypischen Parkinson-Syndrom, stellt die zytoplasmatische Anreicherung von 伪-Synuklein in Oligodendrozyten ein wichtiges pathophysiologisches Merkmal dar. Oligodendrozyten als Myelin-bildende Zellen des Zentralnervensystems tragen wesentlich zur neuronalen Erregungsleitung bei und unterst眉tzen umliegende Nervenzellen durch die Bereitstellung von N盲hrstoffen. In unserer Abteilung konnte mit Hilfe von Tiermodell-basierten <em>in vitro</em> und <em>in vivo</em> Studien gezeigt werden, dass die Anreicherung von 伪-Synuklein ein Reifungsdefizit von Oligodendrozyten bewirkt, welches einen Verlust von Myelin zur Folge hat und sekunda虉r zur Neurodegeneration fu虉hrt. Zus盲tzlich konnten wir unter Nutzung der iPSC-Technologie ein humanes <em>in vitro</em> Modell der MSA etablieren und untersuchen nun den Einfluss einer zellul盲ren 伪-Synuklein Aggregation auf die Biologie und die Funktion humaner Oligodendrozyten.</p><p>Damit MSA-Patienten zuk眉nftig eine kausale Arzneimittel-basierte Behandlung erm枚glicht werden kann, ist die Erforschung von remyelinisierenden Therapieans盲tzen von entscheidender Bedeutung, um die k枚rpereigene Myelinreparatur zu verbessern. In einem MSA-Tiermodell konnten wir bereits erste Hinweise auf einen positiven Effekt durch promyelinogene Substanzen feststellen. Es bedarf nun einer genauen Entschl眉sselung der molekularen Wirkmechanismen dieser Substanzen, um anschlie脽end eine spezifischere und nebenwirkungsarme Medikation zu erm枚glichen.</p><p><strong>Kooperationspartner:</strong><br> Prof. Dr. M. Wegner (Biochemisches Institut, FAU Erlangen)<br> Prof. Dr. T Ba虉uerle (Pra虉klinische Bildgebungsplattform-PIPE, Erlangen)<br> Prof. Dr. Beate Winner (Stammzellbiologische Abteilung, UKER)<br> Prof. Dr. T. Kuhlmann (Institut f眉r Neuropathologie, M眉nster)<br> Prof. Dr. D. Schubert (Lehrstuhl f眉r Werkstoffwissenschaften (Polymerwerkstoffe), Erlangen)</p><p><strong>F枚rderung: </strong><br> IZKF TP E18<br> DFG GRK2162<br> Forschungsfo虉rderung der Deutschen Parkinson Gesellschaft fu虉r junge Wissenschaftler<br> Bayerisches Staatsministerium f眉r Wissenschaft und Kunst (Bayrischer Forschungsverbund: Interaktion von humanen Gehirnzellen, ForInter)</p></div></div></div></div></div></div><div class="section section-before-footer"><div id="c80068" class=" frame frame-default frame-type-custom_logoslider frame-layout-default frame-size-default frame-height-default frame-background-none frame-space-before-none frame-space-after-none frame-no-backgroundimage"><div class="frame-group-container"><div class="frame-group-inner"><div class="frame-container frame-container-default"><div class="frame-inner"><div class="logoslider-wrapper logoslider-wrapper-"><div class="swiper-container logoslider "><div class="swiper-wrapper"><div class="swiper-slide"><a 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