Keith Choate, MD, PhD < Yale School of Medicine

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Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome. Pediatric Dermatology 2024, 41: 523-525. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38273779\" target=\"_blank\">PMID: 38273779</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096062\" target=\"_blank\">PMCID: PMC11096062</a>, <a href=\"https://doi.org/10.1111/pde.15523\" target=\"_blank\">DOI: 10.1111/pde.15523</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"In‐person validation of the Ichthyosis Scoring System","url":"https://pubmed.ncbi.nlm.nih.gov/38234066","author":[{"@type":"Person","name":"Keith Choate","description":"Keith Choate M.D., Ph.D., is a physician-scientist who employs tools of human genetics to understand fundamental mechanisms of disease. 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In‐person validation of the Ichthyosis Scoring System. Pediatric Dermatology 2024, 41: 247-252. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38234066\" target=\"_blank\">PMID: 38234066</a>, <a href=\"https://doi.org/10.1111/pde.15508\" target=\"_blank\">DOI: 10.1111/pde.15508</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin","url":"https://pubmed.ncbi.nlm.nih.gov/37918441","author":[{"@type":"Person","name":"Keith Choate","description":"Keith Choate M.D., Ph.D., is a physician-scientist who employs tools of human genetics to understand fundamental mechanisms of disease. 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Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano 2023, 17: 22046-22059. <a href=\"https://pubmed.ncbi.nlm.nih.gov/37918441\" target=\"_blank\">PMID: 37918441</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655174\" target=\"_blank\">PMCID: PMC10655174</a>, <a href=\"https://doi.org/10.1021/acsnano.3c08644\" target=\"_blank\">DOI: 10.1021/acsnano.3c08644</a>.","@context":"http://schema.org"} </script> <script data-schema="MedicalScholarlyArticle" type="application/ld+json"> {"@type":"MedicalScholarlyArticle","publicationType":"Journal Article","inLanguage":"en-US","headline":"Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program","url":"https://pubmed.ncbi.nlm.nih.gov/37863200","author":[{"@type":"Person","name":"Keith Choate","description":"Keith Choate M.D., Ph.D., is a physician-scientist who employs tools of human genetics to understand fundamental mechanisms of disease. 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His laboratory is funded by the National Institute of Arthritis and of Musculoskeletal and Skin Diseases, a division of the National Institutes of Health.Dr. Choate mentors undergraduate, graduate, and medical students in his laboratory, teaches at Yale Medical School, and trains resident physicians and fellows.","url":"https://medicine.yale.edu/profile/keith-choate/","telephone":"+12037854445","image":{"@type":"ImageObject","url":"https://ysm-res.cloudinary.com/image/upload/c_limit,f_auto,h_630,q_auto,w_1200/v1/yms/prod/95bbfdfc-6d59-4ce4-b761-e504f286ea23","description":"2023-02-08-Keith-Choate-","height":1200,"width":630,"@context":"http://schema.org"},"address":[],"workLocation":[],"honorificSuffix":["MD","PhD"],"award":["ICC 2018","ADA 2017"],"jobTitle":["Aaron B. and Marguerite Lerner Professor and Chair of Dermatology. Professor of Genetics and Pathology. Associate Dean for Physician-Scientist Development"],"affiliation":[{"@type":"Organization","name":"Dean's Advisory Council for LGBTQI Affairs","url":"https://medicine.yale.edu/lgbtqi/","@context":"http://schema.org"},{"@type":"Organization","name":"Dermatology","url":"https://medicine.yale.edu/dermatology/","@context":"http://schema.org"},{"@type":"Organization","name":"Directories","@context":"http://schema.org"},{"@type":"Organization","name":"Genetics","url":"https://medicine.yale.edu/genetics/","@context":"http://schema.org"},{"@type":"Organization","name":"Genomics, Genetics, and Epigenetics","url":"https://www.yalecancercenter.org/research/programs/genetics/","@context":"http://schema.org"},{"@type":"Organization","name":"Medical Dermatology","url":"https://medicine.yale.edu/dermatology/","@context":"http://schema.org"},{"@type":"Organization","name":"Molecular Cell Biology, Genetics and Development","url":"https://medicine.yale.edu/bbs/tracks/molecular-cell-biology-genetics-development/","@context":"http://schema.org"},{"@type":"Organization","name":"Molecular Medicine, Pharmacology, and Physiology","url":"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/","@context":"http://schema.org"},{"@type":"Organization","name":"Office of the Dean, School of Medicine","url":"https://medicine.yale.edu/about/deanoffice/","@context":"http://schema.org"},{"@type":"Organization","name":"Palade House Affiliates","url":"https://medicine.yale.edu/md-program/student-affairs/academic-career-advising-advisory-houses/advisory-houses/palade/","@context":"http://schema.org"},{"@type":"Organization","name":"Pathology","url":"https://medicine.yale.edu/pathology/","@context":"http://schema.org"},{"@type":"Organization","name":"Pathology and Molecular Medicine","url":"https://medicine.yale.edu/pathology/training/graduateprogram/","@context":"http://schema.org"},{"@type":"Organization","name":"Pathology Research","url":"https://medicine.yale.edu/pathology/research/researchers/","@context":"http://schema.org"},{"@type":"Organization","name":"Pediatric Dermatology","url":"https://medicine.yale.edu/dermatology/","@context":"http://schema.org"},{"@type":"Organization","name":"Program in Translational Biomedicine (PTB)","@context":"http://schema.org"},{"@type":"Organization","name":"Psoriasis Treatment Program","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Cancer Center","url":"https://www.yalecancercenter.org/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Dermatology Associates","url":"https://www.yalemedicine.org/departments/dermatology","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Medicine","url":"https://www.yalemedicine.org/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Medicine Outlist","url":"https://medicine.yale.edu/lgbtqi/medicineoutlist/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/","@context":"http://schema.org"},{"@type":"Organization","name":"Yale Ventures","url":"https://ventures.yale.edu/","@context":"http://schema.org"}],"alumniOf":[{"@type":"Organization","name":"Yale- New Haven Hospital (2008)","@context":"http://schema.org"},{"@type":"Organization","name":"Yale University School of Medicine (2008)","@context":"http://schema.org"},{"@type":"Organization","name":"Yale-New Haven Hospital (2005)","@context":"http://schema.org"},{"@type":"Organization","name":"Yale University School of Medicine (2004)","@context":"http://schema.org"},{"@type":"Organization","name":"Yale University, Cell Biology (2001)","@context":"http://schema.org"},{"@type":"Organization","name":"Yale University, Cell Biology (2000)","@context":"http://schema.org"},{"@type":"Organization","name":"Stanford University, Biological Sciences (1995)","@context":"http://schema.org"}],"sameAs":["https://www.yalemedicine.org/specialists/keith-choate"],"@context":"http://schema.org"}],"description":"Chen G, Goldust M, <strong data-id=\"67767\">Choate K</strong>, <span data-id=\"121079\">Cohen J</span>. Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 90: 439-440. <a href=\"https://pubmed.ncbi.nlm.nih.gov/37863200\" target=\"_blank\">PMID: 37863200</a>, <a href=\"https://doi.org/10.1016/j.jaad.2023.10.025\" target=\"_blank\">DOI: 10.1016/j.jaad.2023.10.025</a>.","@context":"http://schema.org"} </script> <script type="text/javascript"> (function (c, a) { if (!a.__SV) { var b = window; try { var d, m, j, k = b.location, f = k.hash; d = function (a, b) { return (m = a.match(RegExp(b + "=([^&]*)"))) ? m[1] : null }; f && d(f, "fpState") && (j = JSON.parse(decodeURIComponent(d(f, "fpState"))), "fpeditor" === j.action && (b.sessionStorage.setItem("_fpcehash", f), history.replaceState(j.desiredHash || "", c.title, k.pathname + k.search))) } catch (n) { } var l, h; window.freshpaint = a; a._i = []; a.init = function (b, d, g) { function c(b, i) { var a = i.split("."); 2 == a.length && (b = b[a[0]], i = a[1]); b[i] = function () { b.push([i].concat(Array.prototype.slice.call(arguments, 0))) } } var e = a; "undefined" !== typeof g ? e = a[g] = [] : g = "freshpaint"; e.people = e.people || []; e.toString = function (b) { var a = "freshpaint"; "freshpaint" !== g && (a += "." + g); b || (a += " (stub)"); return a }; e.people.toString = function () { return e.toString(1) + ".people (stub)" }; l = "disable time_event track track_pageview track_links track_forms track_with_groups add_group set_group remove_group register register_once alias unregister identify name_tag set_config reset opt_in_tracking opt_out_tracking has_opted_in_tracking has_opted_out_tracking clear_opt_in_out_tracking people.set people.set_once people.unset people.increment people.append people.union people.track_charge people.clear_charges people.delete_user people.remove people group page alias ready addEventProperties addInitialEventProperties removeEventProperty addPageviewProperties".split(" "); for (h = 0; h < l.length; h++)c(e, l[h]); var f = "set set_once union unset remove delete".split(" "); e.get_group = function () { function a(c) { b[c] = function () { call2_args = arguments; call2 = [c].concat(Array.prototype.slice.call(call2_args, 0)); e.push([d, call2]) } } for (var b = {}, d = ["get_group"].concat(Array.prototype.slice.call(arguments, 0)), c = 0; c < f.length; c++)a(f[c]); return b }; a._i.push([b, d, g]) }; a.__SV = 1.4; b = c.createElement("script"); b.type = "text/javascript"; b.async = !0; b.src = "undefined" !== typeof FRESHPAINT_CUSTOM_LIB_URL ? 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class="mobile-navigation-dropdown__link">Patients</a></li><li><a href="/research/" class="mobile-navigation-dropdown__link">Researchers</a></li><li><a href="/alumni/" class="mobile-navigation-dropdown__link">Alumni</a></li></ul></div></div></div></div><div style="margin-top:0px" class="base-page"><main class="page-container" tabindex="-1" id="page-container"><article class="profile-details" aria-label="Keith Choate's profile"><header><div class="profile-details-header-banner profile-details-header-banner--tall"><span class="" style="display:inline-block"></span></div><div class="profile-details-header-info profile-details-header-info--with-image profile-details-header-info--with-banner profile-details-header-info--with-cards"><div class="profile-details-header-info__main-info"><h1 class="profile-details-header-info__name">Keith Choate, MD, PhD</h1><span class="profile-details-header-info__title">Aaron B. and Marguerite Lerner Professor and Chair of Dermatology. Professor of Genetics and Pathology. Associate Dean for Physician-Scientist Development</span></div><div class="profile-details-header-info__thumbnail-wrapper"><div class="profile-details-thumbnail profile-details-thumbnail--clickable profile-details-thumbnail--expanded" role="button" aria-label="Download Hi-Res Photo" tabindex="0"><span class="" style="display:inline-block"></span><div class="profile-details-thumbnail__overlay"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-thumbnail__overlay-icon"><path d="M12.001 3.75v12M7.501 11.25l4.5 4.5 4.5-4.5M23.251 15.75v1.5a3 3 0 0 1-3 3h-16.5a3 3 0 0 1-3-3v-1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg><span class="profile-details-thumbnail__overlay-text">Download</span><span class="profile-details-thumbnail__overlay-text">Hi-Res Photo</span></div></div></div><div class="visually-hidden-content" role="presentation"><h2>Cards</h2></div><div 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class="link__label">See All</span></button></div></div><div class="profile-details-header-card__content"><div class="profile-details-appointment-header-card"><a href="https://medicine.yale.edu/dermatology/" class="profile-details-appointment-header-card__title">Dermatology</a><div>Dual, Primary</div></div><div class="profile-details-appointment-header-card"><a href="https://medicine.yale.edu/about/deanoffice/" class="profile-details-appointment-header-card__title">Office of the Dean, School of Medicine</a><div>Dual</div></div></div></article></div></div><div data-index="1" class="slick-slide slick-active" tabindex="-1" aria-hidden="false" style="outline:none;width:50%"><div><article class="profile-details-card profile-details-card--color-mode--light-grey profile-details-header-card" aria-label="Administrative Support"><div class="profile-details-header-card__header"><h3 class="profile-details-header-card__title"><span class="content-overflow" style="-webkit-line-clamp:3">Administrative Support</span></h3></div><div class="profile-details-header-card__content"><section class="profile-details-profile-link-list profile-details-profile-link-list--grey profile-details-profile-link-list--without-padding" aria-label="undefined list"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><a href="/profile/sheila-garcia/" class="profile-details-profile-link" aria-label="Sheila Garcia"><div class="profile-details-profile-link__link-container"><span class="" style="display:inline-block"></span><div class="profile-details-profile-link__content"><span>Sheila Garcia</span><svg 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share-panel__print-icon"><path d="M5.25 17.249h-3a1.5 1.5 0 0 1-1.5-1.5v-7.5a1.5 1.5 0 0 1 1.5-1.5h19.5a1.5 1.5 0 0 1 1.5 1.5v7.5a1.5 1.5 0 0 1-1.5 1.5h-3" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.5px"></path><path d="M3.75 9.749h1.5" style="stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px;stroke-opacity:1"></path><path d="M5.25 12.749h13.5v10H5.25z" class="paper" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:2"></path><path d="M18.75 6.749H5.25v-4.5a1.5 1.5 0 0 1 1.5-1.5h10.5a1.5 1.5 0 0 1 1.5 1.5Z" style="stroke-linecap:round;stroke-linejoin:round;fill:currentColor;stroke-width:.25px;stroke-opacity:1"></path></svg></button></li></ul><section id="about-details-section" aria-label="About"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="about">About</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 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Chair of Dermatology. Professor of Genetics and Pathology. Associate Dean for Physician-Scientist Development</p></div></section><section class="profile-details-content-section" aria-label="about Biography" id="about-biography" tabindex="-1"><h3 class="profile-details-content-section__heading">Biography</h3><div class="profile-details-content-section__content"><div class="profile-details-html-content-section__content"><p xmlns="http://www.w3.org/1999/xhtml">Keith Choate M.D., Ph.D., is a physician-scientist who employs tools of human genetics to understand fundamental mechanisms of disease. His laboratory studies rare inherited and mosaic skin disorders to identify novel genes responsible for epidermal differentiation and development. His laboratory has identified the genetic basis of over 12 disorders and has developed new therapeutic approaches informed by genetic findings. His laboratory is funded by the National Institute of Arthritis and of Musculoskeletal and Skin Diseases, a division of the National Institutes of Health.</p><p xmlns="http://www.w3.org/1999/xhtml">Dr. Choate mentors undergraduate, graduate, and medical students in his laboratory, teaches at Yale Medical School, and trains resident physicians and fellows.</p></div></div></section><section class="profile-details-content-section" aria-label="about Appointments" id="about-appointments" tabindex="-1"><h3 class="profile-details-content-section__heading">Appointments</h3><div class="profile-details-content-section__content"><div class="profile-details-appointment-list"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Chair Dual in Dermatology"><h4 class="profile-details-appointment-card__academic-unit">Dermatology</h4><div class="profile-details-appointment-card__title">Chair</div><div class="profile-details-appointment-card__type">Dual</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/dermatology/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Dermatology</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Associate Dean Dual in Office of the Dean, School of Medicine"><h4 class="profile-details-appointment-card__academic-unit">Office of the Dean, School of Medicine</h4><div class="profile-details-appointment-card__title">Associate Dean</div><div class="profile-details-appointment-card__type">Dual</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/about/deanoffice/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Office of the Dean, School of Medicine</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Primary in Dermatology"><h4 class="profile-details-appointment-card__academic-unit">Dermatology</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Primary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/dermatology/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Dermatology</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Secondary in Genetics"><h4 class="profile-details-appointment-card__academic-unit">Genetics</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Secondary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/genetics/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Genetics</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-appointment-card" aria-label="Professor Secondary in Pathology"><h4 class="profile-details-appointment-card__academic-unit">Pathology</h4><div class="profile-details-appointment-card__title">Professor</div><div class="profile-details-appointment-card__type">Secondary</div><div class="profile-details-appointment-card__link"><a href="https://medicine.yale.edu/pathology/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--blue link--font--bold" aria-label="undefined"><span class="link__label">Pathology</span><span class="link__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-card-link__icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div></article></li></ul></div><h4 class="profile-details-organization-list__header">Other Departments & Organizations</h4><div class="profile-details-organization-list__list"><ul><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/lgbtqi/" tabindex="0" class="hyperlink">Dean's Advisory Council for LGBTQI Affairs</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/dermatology/" tabindex="0" class="hyperlink">Dermatology</a></li><li class="organization-hyperlink-list__item"><span>Directories</span></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/genetics/" tabindex="0" class="hyperlink">Genetics</a></li><li class="organization-hyperlink-list__item"><a href="https://www.yalecancercenter.org/research/programs/genetics/" tabindex="0" class="hyperlink">Genomics, Genetics, and Epigenetics</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/dermatology/" tabindex="0" class="hyperlink">Medical Dermatology</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/tracks/molecular-cell-biology-genetics-development/" tabindex="0" class="hyperlink">Molecular Cell Biology, Genetics and Development</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/" tabindex="0" class="hyperlink">Molecular Medicine, Pharmacology, and Physiology</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/about/deanoffice/" tabindex="0" class="hyperlink">Office of the Dean, School of Medicine</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/md-program/student-affairs/academic-career-advising-advisory-houses/advisory-houses/palade/" tabindex="0" class="hyperlink">Palade House Affiliates</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/pathology/" tabindex="0" class="hyperlink">Pathology</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/pathology/training/graduateprogram/" tabindex="0" class="hyperlink">Pathology and Molecular Medicine</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/pathology/research/researchers/" tabindex="0" class="hyperlink">Pathology Research</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/dermatology/" tabindex="0" class="hyperlink">Pediatric Dermatology</a></li><li class="organization-hyperlink-list__item"><span>Program in Translational Biomedicine (PTB)</span></li><li class="organization-hyperlink-list__item"><span>Psoriasis Treatment Program</span></li><li class="organization-hyperlink-list__item"><a href="https://www.yalecancercenter.org/" tabindex="0" class="hyperlink">Yale Cancer Center</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/ycgh/" tabindex="0" class="hyperlink">Yale Center for Genomic Health</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/bbs/" tabindex="0" class="hyperlink">Yale Combined Program in the Biological and Biomedical Sciences (BBS)</a></li><li class="organization-hyperlink-list__item"><a href="https://www.yalemedicine.org/departments/dermatology" tabindex="0" class="hyperlink">Yale Dermatology Associates</a></li><li class="organization-hyperlink-list__item"><a href="https://www.yalemedicine.org/" tabindex="0" class="hyperlink">Yale Medicine</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/lgbtqi/medicineoutlist/" tabindex="0" class="hyperlink">Yale Medicine Outlist</a></li><li class="organization-hyperlink-list__item"><a href="https://medicine.yale.edu/stemcell/" tabindex="0" class="hyperlink">Yale Stem Cell Center</a></li><li class="organization-hyperlink-list__item"><a href="https://ventures.yale.edu/" tabindex="0" class="hyperlink">Yale Ventures</a></li></ul></div></div></section><section class="profile-details-content-section" aria-label="about Education & Training" id="about-education-and-training" tabindex="-1"><h3 class="profile-details-content-section__heading">Education & Training</h3><div class="profile-details-content-section__content"><div class="profile-details-education-list"><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Resident</dt><dd class="profile-details-education-list__institution">Yale- New Haven Hospital (2008)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Postdoctoral Fellow</dt><dd class="profile-details-education-list__institution">Yale University School of Medicine (2008)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">Intern</dt><dd class="profile-details-education-list__institution">Yale-New Haven Hospital (2005)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">MD</dt><dd class="profile-details-education-list__institution">Yale University School of Medicine (2004)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">PhD</dt><dd class="profile-details-education-list__institution">Yale University, Cell Biology (2001)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">MPhil</dt><dd class="profile-details-education-list__institution">Yale University, Cell Biology (2000)</dd></dl></div><div class="profile-details-education-list__item"><div class="profile-details-education-list__marker profile-details-education-list__marker--last"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="0 0 11 10" focusable="false" class="profile-details-education-list__marker-icon"><circle cx="5.5" cy="5" r="4" fill="#B4E7F8" stroke="#224570" stroke-width="2"></circle></svg></div><dl class="profile-details-education-list__container"><dt class="profile-details-education-list__degree">BS</dt><dd class="profile-details-education-list__institution">Stanford University, Biological Sciences (1995)</dd></dl></div></div></div></section></div></div><div class="profile-details-section-content__sidebar"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><a href="https://beatrix.yale.edu/api/people/profiles/67767/public-cv/download" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link button-with-icon profile-details-about-section-cv-download-button" download="" rel="nofollow"><span class="button__label">Download CV</span><span class="button__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-about-section-cv-download-button__icon"><path d="M5.251 9.25 12 16l6.75-6.75H15V2.5a.75.75 0 0 0-.75-.75h-4.5A.75.75 0 0 0 9 2.5v6.75ZM23.251 17.5v3a1.5 1.5 0 0 1-1.5 1.5h-19.5a1.5 1.5 0 0 1-1.5-1.5v-3" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></li></ul></li></ul></div></div></section><section id="research-details-section" aria-label="Research"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="research">Research</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 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Overview" id="research-overview" tabindex="-1"><h3 class="profile-details-content-section__heading">Overview</h3><div class="profile-details-content-section__content"><div class="profile-details-research-section-overview__description"><p xmlns="http://www.w3.org/1999/xhtml">Genetics has informed our understanding of normal skin development and differentiation, largely due to the fact that mutations affecting the skin result in easily observed phenotypes. Genetic investigation has permitted us to identify <em>a priori </em>pathways previously unrecognized to be relevant to skin biology. These insights have been relevant to diagnosis, disease prevention, and development of novel therapeutics. </p><p xmlns="http://www.w3.org/1999/xhtml"> </p><p xmlns="http://www.w3.org/1999/xhtml">We have three ongoing projects in the lab: </p><p xmlns="http://www.w3.org/1999/xhtml"> 1. Identification of novel genetic causes of inherited skin disorders including ichthyosis, inflammatory disorders and alopecia. We have developed one of the largest registries of kindreds with ichthyosis and have identified over 10 new genetic cause of this group of disorders – we employ cell, murine, and engineered tissue models to understand that biological basis of disease and the role of novel genes in disease pathobiology.</p><p xmlns="http://www.w3.org/1999/xhtml"> 2. Identification of novel genetic causes of mosaic skin disorders including childhood malformations, vascular tumors, and linear presentations of inflammatory disorders. Mosaic disorders are the result of embryonic somatic mutation, with timing of mutation determining the extent of disease. Among other discoveries, we have systematically dissected pathways leading to development of aggressive infantile vascular tumors, identified novel causes of acne pathogenesis and hair follicle differentiation, and have identified Ras as a regulator of phosphate homeostasis. A new project is focused on linear manifestation of common inflammatory disorders such as lupus, psoriasis, and lichen planus with the expectation that investigation will identify novel pathways in cutaneous innate immunity.</p><p xmlns="http://www.w3.org/1999/xhtml"> 3. Elucidation of mechanisms of revertant mosaicism in ichthyosis with confetti to enable therapeutic recombination in the skin. We have found that specific mutations in <em>KRT1</em> and <em>KRT10</em> cause ichthyosis with confetti which undergoes spontaneous self-correction via revertant mosaicism, resulting in hundreds to thousands of patches of normal skin. All spots arise from mitotic recombination, and have found that keratin mutations directly influence DNA damage and repair and that cellular competition favors reversion. We are employing forward genetics to identify the pathways relevant to recombination and competition.</p><p xmlns="http://www.w3.org/1999/xhtml"> </p></div><section class="profile-details-research-section-overview__keyword-container" aria-label="MeSH keyword list"><h4 class="profile-details-research-section-overview__keyword-heading">Medical Subject Headings (MeSH)</h4><div class="profile-details-research-section-overview__keyword">Cell Biology; Genetics; Genetics, Medical; Human Genetics; Human Genome Project; Ichthyosis; Mosaicism; Skin and Connective Tissue Diseases; Skin Diseases</div></section></div></section></div><div class="profile-details-section-content__sidebar"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><section class="profile-details-research-section-orcid" aria-label="Open researcher and contributor id"><h3 class="profile-details-research-section-orcid__heading">ORCID</h3><a href="https://orcid.org/0000-0003-1010-6354/" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link" target="_blank"><span class="button__label profile-details-research-section-orcid__button-label">0000-0003-1010-6354</span></a></section></li><li class="profile-details-column-list-item"><article class="profile-details-lab" aria-label="Lab Website"><div class="profile-details-lab__header"><svg xmlns="http://www.w3.org/2000/svg" fill="none" viewBox="-0.5 -0.5 20 20" focusable="false" class="profile-details-lab__icon"><desc>Lab Whisk Cup Streamline Icon: https://streamlinehq.com</desc><path stroke="currentColor" 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class="profile-details-lab__title">Office of Physician-Scientist and Scientist Development</h3></div><a href="https://medicine.yale.edu/faculty/opssd/" tabindex="0" class="button button--large button--secondary button--color-mode--blue button--link"><span class="button__label">View Lab Website</span></a></article></li></ul></div></div><div class="profile-details-section-content profile-details-section-content--without-sidebar profile-details-research-section__content profile-details-research-section__glance-content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Research at a Glance" id="research-research-at-a-glance" tabindex="-1"><h3 class="profile-details-content-section__heading">Research at a Glance</h3><div class="profile-details-content-section__content"><div class="profile-details-glance-list"><div class="profile-details-glance-list__description-column"><div class="slick-slider slick-initialized" dir="ltr"><div class="slick-list"><div class="slick-track" style="width:700%;left:-100%"><div data-index="0" class="slick-slide slick-active slick-current" tabindex="-1" aria-hidden="false" style="outline:none;width:14.285714285714286%;position:relative;left:0;opacity:1;z-index:999;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Yale Co-Authors</h4><div class="profile-details-glance-description__content">Frequent collaborators of Keith Choate's published research.</div></div></div></div><div data-index="1" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-14px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Publications Timeline</h4><div class="profile-details-glance-description__content">A big-picture view of Keith Choate's research output by year.</div></div></div></div><div data-index="2" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-28px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div class="profile-details-glance-description"><h4 class="profile-details-glance-description__heading">Research Interests</h4><div class="profile-details-glance-description__content">Research topics Keith Choate is interested in exploring.</div></div></div></div></div></div></div><div class="profile-details-glance-list__navigation"><div class="profile-details-slider-navigation profile-details-slider-navigation--color-mode--dark"><button class="profile-details-slider-navigation__arrow-button" type="button" aria-label="Go to slide Research Interests"><span class="slider-navigation__icon"><svg xmlns="http://www.w3.org/2000/svg" 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class="profile-details-coauthors-glance__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Brittany Craiglow, MD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:100px;height:100px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Brittany Craiglow, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/brittany-craiglow/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Brittany Craiglow, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&profilePageName=brittany-craiglow" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Brittany Craiglow, MD and Keith Choate">View 8 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Leonard Milstone, MD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:63px;height:63px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Leonard Milstone, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/leonard-milstone/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Leonard Milstone, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" 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profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Lihi Atzmony Maoz, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/lihi-atzmonymaoz/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Lihi Atzmony Maoz, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&profilePageName=lihi-atzmonymaoz" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Lihi Atzmony Maoz, MD and Keith Choate">View 5 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Jennifer McNiff, MD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:50px;height:50px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Jennifer McNiff, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/jennifer-mcniff/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Jennifer McNiff, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&profilePageName=jennifer-mcniff" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Jennifer McNiff, MD and Keith Choate">View 4 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Christine Ko, MD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:38px;height:38px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Christine Ko, MD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/christine-ko/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Christine Ko, MD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&profilePageName=christine-ko" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to publications search page to find all common items between Christine Ko, MD and Keith Choate">View 3 Common Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-coauthor" aria-label="Co-author Geliang Gan, MPH, PhD"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:25px;height:25px" class="profile-details-glance-figure__entry profile-details-glance-figure__entry--round"></div></div><h5 class="profile-details-coauthor__name">Geliang Gan, MPH, PhD</h5><div class="profile-details-coauthor__profile-link-wrapper"><a href="/profile/geliang-gan/" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Geliang Gan, MPH, PhD's details page"><span class="link__label">View Full Profile</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-coauthor__profile-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-coauthor__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&profilePageName=geliang-gan" tabindex="0" class="hyperlink profile-details-coauthor__publication-link" aria-label="Go to 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class="profile-details-publications-timeline-info__count">4,228</span><span class="profile-details-publications-timeline-info__title">Citations</span></div></div><div class="profile-details-publications-timeline-glance__chart"><canvas role="img" height="150" width="300" aria-label="Publications by Year chart"></canvas></div></section></div></div></div><div data-index="2" class="slick-slide" tabindex="-1" aria-hidden="true" style="outline:none;width:14.285714285714286%;position:relative;left:-28px;opacity:0;z-index:998;transition:opacity 250ms ease, visibility 250ms ease"><div><div tabindex="-1" style="width:100%;display:inline-block"><section class="profile-details-interests-glance" aria-label="Paged research interests list"><div class="profile-details-interests-glance__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Mosaicism"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:100px;height:100px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Mosaicism</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/research-profiles/?orgId=113592&meshId=8628" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Mosaicism YSM Researchers"><span class="link__label">2 YSM Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg 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class="profile-details-interest__keyword">Skin Diseases</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/research-profiles/?orgId=113592&meshId=12313" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Skin Diseases YSM Researchers"><span class="link__label">4 YSM Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=12313" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Skin Diseases">View 3 Related Publications</a></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-interest" aria-label="Research Interest Ichthyosis"><div style="width:100px;height:100px" class="profile-details-glance-figure"><div style="width:60px;height:60px" class="profile-details-glance-figure__entry"></div></div><h5 class="profile-details-interest__keyword">Ichthyosis</h5><div class="profile-details-interest__researcher-link-wrapper"><a href="/research-profiles/?orgId=113592&meshId=6743" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--navy link--font--normal link--with-custom-icon-color" aria-label="Go to Ichthyosis YSM Researchers"><span class="link__label">2 YSM Researchers</span><span class="link__icon link__icon--color--blue" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-interest__researcher-link-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></div><div class="profile-details-interest__publication-link-wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=6743" tabindex="0" class="hyperlink profile-details-interest__publication-link" aria-label="Go to publications search page to find all items related to Ichthyosis">View 3 Related Publications</a></div></article></li></ul></div></section></div></div></div></div></div></div></div><div class="profile-details-glance-list__navigation"><div class="profile-details-slider-navigation profile-details-slider-navigation--color-mode--dark"><button class="profile-details-slider-navigation__arrow-button" type="button" aria-label="Go 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class="profile-details-slider-navigation__arrow-button" type="button" aria-label="Go to slide Publications Timeline"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-slider-navigation__arrow-button-icon"><path d="M23.243 12H.757M11.257 23 22.9 12.751a1 1 0 0 0 0-1.5L11.257 1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></button></div></div></div></div></div></section></div></div><div class="profile-details-section-content profile-details-section-content--with-empty-sidebar profile-details-research-section__content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="research Publications" id="research-publications" tabindex="-1"><h3 class="profile-details-content-section__heading">Publications</h3><div class="profile-details-content-section__content"><section class="profile-publication-card-grouped-list__section" aria-label="2024 Group"><h4 class="profile-publication-card-grouped-list__section-title">2024</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39278313" class="profile-publication-card__link">Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database</a></h5><cite class="profile-publication-card__citation">Curtis K, Echeandia-Francis C, Falotico J, Luo A, Qiu Y, Grover C, Piraccini B, <strong data-id="67767">Choate K</strong>, Lipner S. Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database. Journal Of The American Academy Of Dermatology 2024 <a href="https://pubmed.ncbi.nlm.nih.gov/39278313" target="_blank">PMID: 39278313</a>, <a href="https://doi.org/10.1016/j.jaad.2024.08.063" target="_blank">DOI: 10.1016/j.jaad.2024.08.063</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="LB974 Mutation spectrum of cutaneous vascular anomalies"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://doi.org/10.1016/j.jid.2024.06.1150" class="profile-publication-card__link">LB974 Mutation spectrum of cutaneous vascular anomalies</a></h5><cite class="profile-publication-card__citation">shah K, Goldust M, Ellis K, Ugwu N, Hu R, <span data-id="59193">Zhou J</span>, <strong data-id="67767">Choate K</strong>. LB974 Mutation spectrum of cutaneous vascular anomalies. Journal Of Investigative Dermatology 2024, 144: s171. <a href="https://doi.org/10.1016/j.jid.2024.06.1150" target="_blank">DOI: 10.1016/j.jid.2024.06.1150</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/39060641" class="profile-publication-card__link">Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment</a></h5><cite class="profile-publication-card__citation">Hunt M, Wang N, Pupinyo N, Curman P, Torres M, Jebril W, Chatzinikolaou M, Lorent J, Silberberg G, Bansal R, Burner T, Zhou J, Kimeswenger S, Hoetzenecker W, <strong data-id="67767">Choate K</strong>, Bachar-Wikstrom E, Wikstrom J. Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment. EMBO Molecular Medicine 2024, 16: 1986-2001. <a href="https://pubmed.ncbi.nlm.nih.gov/39060641" target="_blank">PMID: 39060641</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392931" target="_blank">PMCID: PMC11392931</a>, <a href="https://doi.org/10.1038/s44321-024-00104-3" target="_blank">DOI: 10.1038/s44321-024-00104-3</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-0" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-0" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-0" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Darier%27s%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Darier's disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20stress" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">ER stress</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cell%20adhesion" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cell adhesion</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20calcium%20levels" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">ER calcium levels</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Upregulation%20of%20ER%20stress" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Upregulation of ER stress</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Inhibited%20calcium%20release" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Inhibited calcium release</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Ryanodine%20receptor%20antagonist" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ryanodine receptor antagonist</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Endoplasmic%20reticulum%20calcium%20homeostasis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Endoplasmic reticulum calcium homeostasis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Target%20pathogenic%20mechanisms" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Target pathogenic mechanisms</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Features%20of%20Darier%27s%20disease" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Features of Darier's disease</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Identified%20dysregulated%20genes" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Identified dysregulated genes</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Mechanisms%20of%20DD" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mechanisms of DD</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Non-dermatological%20indications" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Non-dermatological indications</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cellular%20calcium%20dynamics" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cellular calcium dynamics</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cellular%20functions" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cellular functions</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20calcium" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">ER calcium</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Homeostasis%20pathways" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Homeostasis pathways</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ATP2A2%20gene" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">ATP2A2 gene</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=In%20vitro%20model" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">In vitro model</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Receptor%20antagonist" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Receptor antagonist</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pumps%20calcium" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pumps calcium</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Calcium%20release" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Calcium release</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Promote%20cell%20adhesion" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Promote cell adhesion</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Isoform%202" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Isoform 2</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Suppressed%20apoptosis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Suppressed apoptosis</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38598229" class="profile-publication-card__link">Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling</a></h5><cite class="profile-publication-card__citation">Velasco R, Shao C, Cutler B, Strunck J, Kent G, Cassidy P, <strong data-id="67767">Choate K</strong>, Greiling T. Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling. JAMA Dermatology 2024, 160: 641-645. <a href="https://pubmed.ncbi.nlm.nih.gov/38598229" target="_blank">PMID: 38598229</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007649" target="_blank">PMCID: PMC11007649</a>, <a href="https://doi.org/10.1001/jamadermatol.2024.0257" target="_blank">DOI: 10.1001/jamadermatol.2024.0257</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-1" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-1" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-1" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Psoriasis%20Area%20Severity%20Index" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Psoriasis Area Severity Index</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pityriasis%20rubra%20pilaris" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pityriasis rubra pilaris</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dermatology%20Life%20Quality%20Index%20scores" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dermatology Life Quality Index scores</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Involvement%20of%20interleukins" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Involvement of interleukins</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Quality%20Index%20score" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Quality Index score</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Food%20and%20Drug%20Administration-approved%20treatment" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Food and Drug Administration-approved treatment</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Primary%20outcome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Primary outcome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=US%20Food%20and%20Drug%20Administration-approved%20treatment" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">US Food and Drug Administration-approved treatment</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Psoriasis%20area%20severity%20index%20score" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Psoriasis area severity index score</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Sex-matched%20healthy%20controls" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Sex-matched healthy controls</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23p19%20inhibitors" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">IL-23p19 inhibitors</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=P19%20subunit%20of%20IL-23" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">P19 subunit of IL-23</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Index%20score" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Index score</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Area%20Severity%20Index" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Area Severity Index</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23%2FIL-17" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">IL-23/IL-17</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Subunit%20of%20IL-23" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Subunit of IL-23</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Per-protocol%20analysis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Per-protocol analysis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20response" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical response</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Study%20drug" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Study drug</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dosing%20schedule" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dosing schedule</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20responders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical responders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20improvement" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical improvement</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Male%20patients" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Male patients</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">IL-23</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Guselkumab" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Guselkumab</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38952857" class="profile-publication-card__link">Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab</a></h5><cite class="profile-publication-card__citation">Singh K, Breidbart R, Jaiswal A, Damsky W, <strong data-id="67767">Choate K</strong>, <span data-id="98502">Vesely M</span>. Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. JAAD Case Reports 2024, 49: 102-105. <a href="https://pubmed.ncbi.nlm.nih.gov/38952857" target="_blank">PMID: 38952857</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214983" target="_blank">PMCID: PMC11214983</a>, <a href="https://doi.org/10.1016/j.jdcr.2024.05.002" target="_blank">DOI: 10.1016/j.jdcr.2024.05.002</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Case Reports and Technical Notes</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="How Efforts to Understand Somatic Mosaicism Will Impact Dermatology"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38395493" class="profile-publication-card__link">How Efforts to Understand Somatic Mosaicism Will Impact Dermatology</a></h5><cite class="profile-publication-card__citation"><span data-id="127642">Mortlock R</span>, <strong data-id="67767">Choate K</strong>. How Efforts to Understand Somatic Mosaicism Will Impact Dermatology. Journal Of Investigative Dermatology 2024, 144: 453-455. <a href="https://pubmed.ncbi.nlm.nih.gov/38395493" target="_blank">PMID: 38395493</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009867" target="_blank">PMCID: PMC11009867</a>, <a href="https://doi.org/10.1016/j.jid.2023.10.007" target="_blank">DOI: 10.1016/j.jid.2023.10.007</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-2" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-2" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-2" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=3710" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dermatology</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=8628" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mosaicism</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=8746" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mutation</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38273779" class="profile-publication-card__link">Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome</a></h5><cite class="profile-publication-card__citation">Haller C, Leszczynska M, Brichta L, Maier E, Riddington I, <strong data-id="67767">Choate K</strong>, Levy M. Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome. Pediatric Dermatology 2024, 41: 523-525. <a href="https://pubmed.ncbi.nlm.nih.gov/38273779" target="_blank">PMID: 38273779</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096062" target="_blank">PMCID: PMC11096062</a>, <a href="https://doi.org/10.1111/pde.15523" target="_blank">DOI: 10.1111/pde.15523</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-3" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-3" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-3" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Schimmelpenning-Feuerstein-Mims" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Schimmelpenning-Feuerstein-Mims</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Sebaceous%20nevus" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Sebaceous nevus</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Downstream%20of%20KRAS" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Downstream of KRAS</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Schimmelpenning-Feuerstein-Mims%20syndrome" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Schimmelpenning-Feuerstein-Mims syndrome</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Oral%20trametinib" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Oral trametinib</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=MAPK%20signaling%20pathway" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">MAPK signaling pathway</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Skin%20involvement" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Skin involvement</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Trametinib" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Trametinib</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Decreased%20pruritus" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Decreased pruritus</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pathogenic%20variants" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Pathogenic variants</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Topical%20use" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Topical use</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dermatological%20conditions" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Dermatological conditions</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Signaling%20pathway" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Signaling pathway</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=KRAS" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">KRAS</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Nevi" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Nevi</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="In‐person validation of the Ichthyosis Scoring System"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/38234066" class="profile-publication-card__link">In‐person validation of the Ichthyosis Scoring System</a></h5><cite class="profile-publication-card__citation">Echeandia‐Francis C, Sun Q, Asch S, Bayart C, Benjamin L, Cipriano S, <span data-id="84663">Craiglow B</span>, Dyer J, Levy M, Lilly E, Newell B, <span data-id="152248">Liang J</span>, <span data-id="58646">Gan G</span>, <span data-id="73401">Deng Y</span>, Paller A, <strong data-id="67767">Choate K</strong>. In‐person validation of the Ichthyosis Scoring System. Pediatric Dermatology 2024, 41: 247-252. <a href="https://pubmed.ncbi.nlm.nih.gov/38234066" target="_blank">PMID: 38234066</a>, <a href="https://doi.org/10.1111/pde.15508" target="_blank">DOI: 10.1111/pde.15508</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-4" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-4" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-4" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Interrater%20intraclass%20correlation%20coefficients" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Interrater intraclass correlation coefficients</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Intrarater%20reliability" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intrarater reliability</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=In-person" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">In-person</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Intraclass%20correlation%20coefficient" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intraclass correlation coefficient</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=In-person%20evaluation" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">In-person evaluation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Content%20validity" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Content validity</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Interrater%20reliability" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Interrater reliability</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Heterogeneous%20group%20of%20skin%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Heterogeneous group of skin disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Group%20of%20skin%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Group of skin disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Intrarater" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Intrarater</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Medical%20professionals" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Medical professionals</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Interrater%20agreement" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Interrater agreement</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Erythema%20evaluation" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Erythema evaluation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Ichthyosis%20subtypes" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ichthyosis subtypes</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Photographic%20evaluation" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Photographic evaluation</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Erythema%20score" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Erythema score</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Interrater" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Interrater</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Erythema" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Erythema</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Quantify%20severity" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Quantify severity</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Skin%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Skin disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20utility" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Clinical utility</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Ichthyosis" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ichthyosis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Scoring%20system" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Scoring system</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Heterogeneous%20group" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Heterogeneous group</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Correlation%20coefficient" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Correlation coefficient</span></a></span></div></div></div></div></div></div></article></li></ul></section><section class="profile-publication-card-grouped-list__section" aria-label="2023 Group"><h4 class="profile-publication-card-grouped-list__section-title">2023</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/37918441" class="profile-publication-card__link">Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin</a></h5><cite class="profile-publication-card__citation">Bolsoni J, Liu D, Mohabatpour F, Ebner R, Sadhnani G, Tafech B, Leung J, Shanta S, An K, Morin T, Chen Y, Arguello A, <strong data-id="67767">Choate K</strong>, Jan E, Ross C, Brambilla D, Witzigmann D, Kulkarni J, Cullis P, Hedtrich S. Lipid Nanoparticle-Mediated Hit-and-Run Approaches Yield Efficient and Safe In Situ Gene Editing in Human Skin. ACS Nano 2023, 17: 22046-22059. <a href="https://pubmed.ncbi.nlm.nih.gov/37918441" target="_blank">PMID: 37918441</a>, <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10655174" target="_blank">PMCID: PMC10655174</a>, <a href="https://doi.org/10.1021/acsnano.3c08644" target="_blank">DOI: 10.1021/acsnano.3c08644</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Citations</div></div><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-5" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-5" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords and Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-5" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">MeSH Keywords</span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=28482" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene Editing</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=6498" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humans</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=7718" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Liposomes</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=24130" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Nanoparticles</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=11729" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ribonucleoproteins</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=11794" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">RNA, Messenger</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=12313" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Skin Diseases</span></a></span></div></div><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">Concepts</span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Lipid%20nanoparticles" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Lipid nanoparticles</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=LNP%20composition" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">LNP composition</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Gene%20editing%20rates" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene editing rates</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Gene%20editing" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene editing</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Gene%20editing%20tools" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Gene editing tools</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Ionizable%20lipids" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ionizable lipids</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Efficient%20delivery" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Efficient delivery</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Delivery%20barriers" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Delivery barriers</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cas9%20RNP" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cas9 RNP</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Monogenic%20skin%20diseases" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Monogenic skin diseases</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Off-target%20effects" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Off-target effects</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Nanoparticles" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Nanoparticles</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Editing%20rates" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Editing rates</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Editing%20tools" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Editing tools</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cas9%20mRNA" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Cas9 mRNA</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Genetic%20tools" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Genetic tools</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Human%20skin" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Human skin</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Editing" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Editing</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=High%202D" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">High 2D</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Skin%20tissue" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Skin tissue</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Exciting%20advances" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Exciting advances</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Efficient" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Efficient</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Layer" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Layer</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Delivery" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Delivery</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Epidermal%20layer" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Epidermal layer</span></a></span></div></div></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-publication-card" aria-label="Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program"><div class="profile-publication-card__content-container"><div class="profile-publication-card__content"><h5 class="profile-publication-card__title"><a href="https://pubmed.ncbi.nlm.nih.gov/37863200" class="profile-publication-card__link">Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program</a></h5><cite class="profile-publication-card__citation">Chen G, Goldust M, <strong data-id="67767">Choate K</strong>, <span data-id="121079">Cohen J</span>. Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 90: 439-440. <a href="https://pubmed.ncbi.nlm.nih.gov/37863200" target="_blank">PMID: 37863200</a>, <a href="https://doi.org/10.1016/j.jaad.2023.10.025" target="_blank">DOI: 10.1016/j.jaad.2023.10.025</a>.</cite><div class="profile-publication-card__category">Peer-Reviewed Original Research</div></div><div class="profile-publication-card__badge-container" aria-hidden="true"><div class="profile-publication-card__badge"><div class="profile-publication-card__badge-label">Altmetric</div></div></div></div><div class="profile-publication-card__keyword-accordion"><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div data-accordion-component="AccordionItemHeading" aria-level="6" role="heading" class="accordion__heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-6" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-6" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">MeSH Keywords and Concepts</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="accordion__panel" id="accordion__panel-raa-6" hidden=""><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">MeSH Keywords</span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=955" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Anxiety</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=15166" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Case-Control Studies</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=3693" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Depression</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=6498" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Humans</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=6743" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Ichthyosis</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=18483" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mood Disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=28899" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Population Health</span></a></span></div></div><div class="profile-publication-card-keyword-accordion__container"><div class="profile-publication-card-keyword-list"><span class="profile-publication-card-keyword-list__keyword-label">Concepts</span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Case-control%20study" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Case-control study</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Mood%20disorders" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Mood disorders</span></a></span><span class="profile-publication-card-keyword-list__keyword"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Us%20Research%20Program" tabindex="0" class="link link--size--small link--width--float link--align--right link--color--black link--font--normal link--decorate-color--light-blue"><span class="link__label">Us Research Program</span></a></span></div></div></div></div></div></div></article></li></ul></section><div class="profile-details-see-all-button profile-details-see-all-button--width-mode--normal"><div class="profile-details-see-all-button__wrapper"><a href="/profile/keith-choate/academic-publications/?profilePageName=keith-choate" tabindex="0" class="button button--large button--primary button--color-mode--blue button--link button-with-icon"><span class="button__label">See All Publications</span><span class="button__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-see-all-button__icon"><path fill="currentcolor" fill-rule="evenodd" d="M14.004.525a.503.503 0 0 0 .017.926c.08.033.513.037 3.936.037h3.847l-8.416 8.418c-4.628 4.63-8.434 8.455-8.456 8.5a.6.6 0 0 0-.04.221.49.49 0 0 0 .67.465c.1-.037 1.101-1.028 8.532-8.457l8.418-8.415v3.785c0 2.678.008 3.82.027 3.909a.49.49 0 0 0 .488.385c.2 0 .361-.1.454-.283.035-.07.039-.493.04-4.62V.853l-.056-.108a.45.45 0 0 0-.172-.18l-.117-.073-4.538-.006c-4.377-.005-4.541-.004-4.634.04M2.108 4.895a2 2 0 0 0-1.45 1.116c-.195.412-.18-.328-.173 8.268l.007 7.668.066.192c.241.704.827 1.22 1.524 1.345.156.028 1.406.033 7.7.034 6.671 0 7.54-.003 7.729-.036.773-.135 1.426-.783 1.574-1.564.024-.129.031-.971.031-3.991 0-4.228.013-3.88-.147-4.04a.44.44 0 0 0-.357-.144c-.16 0-.253.038-.351.144-.152.163-.141-.145-.141 3.925 0 2.049-.01 3.77-.022 3.851a.97.97 0 0 1-.768.824c-.19.036-14.908.033-15.079-.003a.96.96 0 0 1-.718-.637c-.044-.131-.045-.378-.045-7.65 0-8.004-.005-7.595.108-7.814.058-.112.214-.274.344-.357.24-.155.018-.147 4.174-.147 3.359 0 3.785-.004 3.865-.037a.505.505 0 0 0 0-.934c-.08-.033-.507-.037-3.924-.034-2.11.001-3.885.011-3.947.022"></path></svg></span></a></div></div></div></section><section class="profile-details-content-section" aria-label="research Clinical Trials" id="research-clinical-trials" tabindex="-1"><h3 class="profile-details-content-section__heading">Clinical Trials</h3><div class="profile-details-content-section__content"><div class="profile-details-research-section__trial-container"><h4 class="profile-details-research-section-clinical-trial-list__heading">Current Trials</h4><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-clinical-trial-card" aria-label="Does Ichthyosis Affect Growth Among Children?"><div class="profile-clinical-trial-card__content"><h5 class="profile-clinical-trial-card__title"><a href="/trial/clinical-and-genetic-studies-of-inherited-skin-disorders/" class="profile-clinical-trial-card__link">Does Ichthyosis Affect Growth Among Children?</a></h5><div class="profile-clinical-trial-card__info"><span class="profile-clinical-trial-card-info"><span class="profile-clinical-trial-card-info__container"><span class="profile-clinical-trial-card-info__title">HIC ID</span><span class="profile-clinical-trial-card-info__data">0809004252</span></span><span class="profile-clinical-trial-card-info__separator"></span></span><span class="profile-clinical-trial-card-info"><span class="profile-clinical-trial-card-info__container"><span class="profile-clinical-trial-card-info__title">Role</span><span class="profile-clinical-trial-card-info__data">Principal Investigator</span></span><span class="profile-clinical-trial-card-info__separator"></span></span><span class="profile-clinical-trial-card-info"><span class="profile-clinical-trial-card-info__container"><span class="profile-clinical-trial-card-info__title">Primary Completion Date</span><span class="profile-clinical-trial-card-info__data">10/15/2028</span></span></span></div><div class="profile-clinical-trial-card__info"><span class="profile-clinical-trial-card__status"><span class="profile-clinical-trial-card__status-container"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-clinical-trial-card__status-icon"><path d="M7.146 10.853a1.207 1.207 0 0 1 1.708 0L11 13l9.146-9.146a1.207 1.207 0 0 1 1.708 0l1.292 1.293a1.206 1.206 0 0 1 0 1.707L11.854 18.146a1.21 1.21 0 0 1-1.708 0l-4.292-4.293a1.206 1.206 0 0 1 0-1.707ZM4.113 11.113l-.259-.26a1.207 1.207 0 0 0-1.708 0L.854 12.146a1.206 1.206 0 0 0 0 1.707l4.292 4.293a1.21 1.21 0 0 0 1.708 0l.232-.233M17.086 4.085l-.232-.232a1.207 1.207 0 0 0-1.708 0L9.884 9.115" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg><span class="profile-clinical-trial-card__status-title">Recruiting Participants</span></span><span class="profile-clinical-trial-card__separator"></span></span><span class="profile-clinical-trial-card-info"><span class="profile-clinical-trial-card-info__container"><span class="profile-clinical-trial-card-info__title">Gender</span><span class="profile-clinical-trial-card-info__data">Both</span></span><span class="profile-clinical-trial-card-info__separator"></span></span><span class="profile-clinical-trial-card-info"><span class="profile-clinical-trial-card-info__container"><span class="profile-clinical-trial-card-info__title">Age</span><span class="profile-clinical-trial-card-info__data">Up to 25 years</span></span></span></div><div class="profile-clinical-trial-card__categories"><span><a href="/search/?entityType=ClinicalTrial&profilePageName=keith-choate&categoryId=46" tabindex="0" class="hyperlink profile-clinical-trial-card__category-link" aria-label="View clinical trials related to Skin/Dermatology category">Skin/Dermatology</a></span><span><a href="/search/?entityType=ClinicalTrial&profilePageName=keith-choate&categoryId=18" tabindex="0" class="hyperlink profile-clinical-trial-card__category-link" aria-label="View clinical trials related to Genetics category">Genetics</a></span></div></div></article></li></ul></div></div></section></div><div class="profile-details-section-content__sidebar"></div></div></section><section id="achievements-details-section" aria-label="Academic Achievements & Community Involvement"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="academic-achievements-and-community-involvement">Academic Achievements & Community Involvement</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></header><div class="profile-details-section-content profile-details-section-content--with-empty-sidebar"><div class="profile-details-section-content__main"><ul class="profile-details-column-list profile-details-column-list--gap-mode--small profile-details-column-list--gap-mode-on-desktop--small profile-details-column-list--gap-mode-on-tablet--small profile-details-column-list--gap-mode-on-mobile--small profile-details-column-list--columns-on-desktop--1 profile-details-column-list--columns-on-tablet--1 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--activity" aria-label="Associate Director Yale Medical Scientist Training Program"><span class="achievement-card__label">activity</span><h3 class="achievement-card__title">Associate Director Yale Medical Scientist Training Program</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Committees</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Director</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-7" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-7" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Details</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="achievement-card__details-container" id="accordion__panel-raa-7" hidden=""><span class="achievement-service-card__date-container"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-service-card__icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>07/01/2015 - Present</span></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--honor" aria-label="ICC"><span class="achievement-card__label">honor</span><h3 class="achievement-card__title">ICC</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Regional Award</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Interurban Clinical Club</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-8" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-8" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Details</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="achievement-card__details-container" id="accordion__panel-raa-8" hidden=""><div class="achievement-honor-card__metadata-list"><span class="achievement-honor-card__metadata-item"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-honor-card__metadata-item-icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>05/25/2018</span><span class="achievement-honor-card__metadata-separator"></span><span class="achievement-honor-card__metadata-item"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-honor-card__metadata-item-icon"><circle cx="12" cy="7.5" r="3" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></circle><path d="M12 .75a6.75 6.75 0 0 1 6.75 6.75c0 3.251-5.132 10.527-6.446 12.337a.377.377 0 0 1-.608 0C10.382 18.027 5.25 10.751 5.25 7.5A6.75 6.75 0 0 1 12 .75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path><path d="M17.979 17.784c2.732.541 4.521 1.444 4.521 2.466 0 1.657-4.7 3-10.5 3s-10.5-1.343-10.5-3c0-1.02 1.781-1.921 4.5-2.463" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>United States</span></div></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--activity" aria-label="Medical and Scientific Advisory Board, Foundation for Ichthyosis and Related Skin Types"><span class="achievement-card__label">activity</span><h3 class="achievement-card__title">Medical and Scientific Advisory Board, Foundation for Ichthyosis and Related Skin Types</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Public Service</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Member</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-9" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-9" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Details</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="achievement-card__details-container" id="accordion__panel-raa-9" hidden=""><span class="achievement-service-card__date-container"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-service-card__icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>07/01/2010 - 08/09/2017</span></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--activity" aria-label="Board of Directors, Foundation for Ichthyosis and Related Skin Types"><span class="achievement-card__label">activity</span><h3 class="achievement-card__title">Board of Directors, Foundation for Ichthyosis and Related Skin Types</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">Public Service</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">Member</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-10" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-10" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Details</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="achievement-card__details-container" id="accordion__panel-raa-10" hidden=""><span class="achievement-service-card__date-container"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-service-card__icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>2015 - 2017</span></div></div></div></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white achievement-card achievement-card--type--honor" aria-label="ADA"><span class="achievement-card__label">honor</span><h3 class="achievement-card__title">ADA</h3><div data-accordion-component="Accordion" class="accordion"><div data-accordion-component="AccordionItem" class="accordion__item"><div class="achievement-card__metadata-list"><span class="achievement-card__metadata-container"><span class="achievement-card__metadata">National Award</span><span class="achievement-card__separator"></span></span><span class="achievement-card__metadata-container"><span class="achievement-card__metadata achievement-card__metadata--highlighted">American Dermatological Association</span></span></div><div data-accordion-component="AccordionItemHeading" class="achievement-card__details-button-container" aria-level="4" role="heading"><div class="profile-accordion-item-button profile-accordion-item-button--color-mode--navy profile-accordion-item-button--thickness-mode--bold profile-accordion-item-button--text-size-mode--default profile-accordion-item-button--content-alignment-mode--default" id="accordion__heading-raa-11" aria-disabled="false" aria-expanded="false" aria-controls="accordion__panel-raa-11" role="button" tabindex="0" data-accordion-component="AccordionItemButton"><span class="profile-accordion-item-button__label">Details</span><span class="animated-expand-icon"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="animated-expand-icon__icon"><path d="M12 1v22M23 12H1" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round"></path></svg></span></div></div><div data-accordion-component="AccordionItemPanel" class="achievement-card__details-container" id="accordion__panel-raa-11" hidden=""><div class="achievement-honor-card__metadata-list"><span class="achievement-honor-card__metadata-item"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-honor-card__metadata-item-icon"><rect width="22.5" height="19.5" x="0.75" y="3.75" rx="1.5" ry="1.5" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></rect><path d="M.75 9.75h22.5M6.75 6V.75M17.25 6V.75M5.625 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M5.625 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M12 13.5a.375.375 0 1 0 .375.375A.375.375 0 0 0 12 13.5M12 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 13.5a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375M18.375 18.75a.375.375 0 1 0 .375.375.375.375 0 0 0-.375-.375" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>07/01/2017</span><span class="achievement-honor-card__metadata-separator"></span><span class="achievement-honor-card__metadata-item"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="achievement-honor-card__metadata-item-icon"><circle cx="12" cy="7.5" r="3" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></circle><path d="M12 .75a6.75 6.75 0 0 1 6.75 6.75c0 3.251-5.132 10.527-6.446 12.337a.377.377 0 0 1-.608 0C10.382 18.027 5.25 10.751 5.25 7.5A6.75 6.75 0 0 1 12 .75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path><path d="M17.979 17.784c2.732.541 4.521 1.444 4.521 2.466 0 1.657-4.7 3-10.5 3s-10.5-1.343-10.5-3c0-1.02 1.781-1.921 4.5-2.463" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg>United States</span></div></div></div></div></article></li></ul><div class="profile-details-see-all-button profile-details-see-all-button--width-mode--normal"><div class="profile-details-see-all-button__wrapper"><a href="/profile/keith-choate/profile-achievements/?profilePageName=keith-choate" tabindex="0" class="button button--large button--primary button--color-mode--blue button--link button-with-icon"><span class="button__label">See All Achievements</span><span class="button__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-see-all-button__icon"><path fill="currentcolor" fill-rule="evenodd" d="M14.004.525a.503.503 0 0 0 .017.926c.08.033.513.037 3.936.037h3.847l-8.416 8.418c-4.628 4.63-8.434 8.455-8.456 8.5a.6.6 0 0 0-.04.221.49.49 0 0 0 .67.465c.1-.037 1.101-1.028 8.532-8.457l8.418-8.415v3.785c0 2.678.008 3.82.027 3.909a.49.49 0 0 0 .488.385c.2 0 .361-.1.454-.283.035-.07.039-.493.04-4.62V.853l-.056-.108a.45.45 0 0 0-.172-.18l-.117-.073-4.538-.006c-4.377-.005-4.541-.004-4.634.04M2.108 4.895a2 2 0 0 0-1.45 1.116c-.195.412-.18-.328-.173 8.268l.007 7.668.066.192c.241.704.827 1.22 1.524 1.345.156.028 1.406.033 7.7.034 6.671 0 7.54-.003 7.729-.036.773-.135 1.426-.783 1.574-1.564.024-.129.031-.971.031-3.991 0-4.228.013-3.88-.147-4.04a.44.44 0 0 0-.357-.144c-.16 0-.253.038-.351.144-.152.163-.141-.145-.141 3.925 0 2.049-.01 3.77-.022 3.851a.97.97 0 0 1-.768.824c-.19.036-14.908.033-15.079-.003a.96.96 0 0 1-.718-.637c-.044-.131-.045-.378-.045-7.65 0-8.004-.005-7.595.108-7.814.058-.112.214-.274.344-.357.24-.155.018-.147 4.174-.147 3.359 0 3.785-.004 3.865-.037a.505.505 0 0 0 0-.934c-.08-.033-.507-.037-3.924-.034-2.11.001-3.885.011-3.947.022"></path></svg></span></a></div></div></div><div class="profile-details-section-content__sidebar"></div></div></section><section id="clinical-care-details-section" aria-label="Clinical Care"><header class="profile-details-section-header"><div class="heading__container"><h2 class="profile-details-section-header__heading" tabindex="-1" id="clinical-care">Clinical Care</h2><div class="heading__anchor-copy-button-container"><button type="button" aria-label="Copy Link" class="anchor-copy-button anchor-copy-button--color-mode--light"><span class="anchor-copy-button__content"><span class="anchor-copy-button__text">Copy Link</span><svg xmlns="http://www.w3.org/2000/svg" xml:space="preserve" viewBox="0 0 24 24" focusable="false" class="anchor-copy-button__icon"><path d="M5.253 21.497a5.21 5.21 0 0 1-3.712-1.535A5.21 5.21 0 0 1 .006 16.25c0-1.404.545-2.722 1.535-3.712l4.773-4.774a5.22 5.22 0 0 1 3.716-1.539c1.402 0 2.719.544 3.708 1.531a5.225 5.225 0 0 1 .538 6.804.75.75 0 0 1-1.048.165.74.74 0 0 1-.299-.489.75.75 0 0 1 .134-.558 3.73 3.73 0 0 0-.384-4.86 3.73 3.73 0 0 0-2.649-1.094 3.73 3.73 0 0 0-2.655 1.099l-4.774 4.774a3.754 3.754 0 0 0 0 5.303c.707.707 1.649 1.096 2.652 1.096s1.945-.389 2.652-1.096l.932-.932a.744.744 0 0 1 1.06 0 .744.744 0 0 1 0 1.06l-.932.932a5.2 5.2 0 0 1-3.712 1.537"></path><path d="M13.978 18.024a5.21 5.21 0 0 1-3.709-1.535 5.22 5.22 0 0 1-.536-6.803.75.75 0 0 1 1.047-.166.75.75 0 0 1 .3.49.75.75 0 0 1-.134.558 3.73 3.73 0 0 0 .383 4.859 3.73 3.73 0 0 0 2.65 1.096 3.73 3.73 0 0 0 2.654-1.1l4.773-4.773c.708-.708 1.098-1.65 1.098-2.652s-.39-1.943-1.098-2.652c-.707-.707-1.649-1.096-2.652-1.096s-1.945.389-2.652 1.096l-.75.75a.744.744 0 0 1-1.06 0c-.142-.141-.22-.33-.22-.53s.078-.389.22-.53l.75-.75c.99-.99 2.309-1.536 3.712-1.536s2.722.545 3.712 1.536a5.21 5.21 0 0 1 1.538 3.712 5.21 5.21 0 0 1-1.538 3.712l-4.773 4.773a5.21 5.21 0 0 1-3.711 1.54z"></path></svg></span></button></div></div></header><div class="profile-details-section-content"><div class="profile-details-section-content__main"><section class="profile-details-content-section" aria-label="clinicalCare Overview" id="clinical-care-overview" tabindex="-1"><h3 class="profile-details-content-section__heading">Overview</h3><div class="profile-details-content-section__content"><div class="profile-details-clinical-care-section-content__bio"><p>Keith Choate, MD, PhD, is a professor of dermatology, genetics and pathology at Yale School of Medicine and a medical dermatologist who treats patients with a variety of skin conditions, including skin cancer, severe acne, psoriasis, and other conditions upon referral by a dermatologist. His expertise in genetic skin disorders leads to referrals from across the country and around the world. Regarding the complex cases he sees, Dr. Choate says, “There's nothing better than solving a medical mystery, and it’s enormously gratifying to see patients get better.”</p> <p>He reports that some patients have seen many other doctors before coming to Yale Medicine Dermatology, and that they are surprised to discover how things are done differently at Yale Medicine. As a physician-scientist, Dr. Choate and others in the department bring insights from scientific investigation and clinical trials to patient care. “At the end of the day, there's always an answer to complex skin problems if we are willing to work together toward finding a solution,” says Dr. Choate. </p> <p>Dr. Choate is co-chief of dermatology at the Saint Raphael campus, director of research of the Yale Medicine Department of Dermatology, and an associate director of the Yale Medical Scientist Program. He reports that “having the opportunity to train the next generation of clinicians and physician-scientists who will shape medicine is an inspiring part of what I do.” </p> <p>In his own research, Dr. Choate employs genetic tool and biologic investigation to find solutions for other genetic disorders such as ichthyosis, palmoplantar keratoderma and disorders appearing in patches or stripes on the skin. These include mosaic manifestations of acne, lichen planus, lupus and psoriasis. </p> <p>To that end, Dr. Choate has recently published research on a group of severe, genetic skin conditions called ichthyosis, which cause dry, scaly or thickened skin. They affect about 200,000 people and can be disfiguring. In his new research, he and colleagues found a commonly used acne medication called isotretinoin (Accutane), counteracts the effects of the genetic mutations the disorder causes. “In two patients who’ve utilized it, the medication has cured the disease,” Dr. Choate says.</p> <p>“Yale Medicine’s approach to patient care, disease-centered research, and education gives me a unique opportunity to make a difference in patients’ lives. This is why I come to work every day,” Dr. Choate says. </p></div><div class="profile-details-clinical-care-section-content__specialties"><section class="profile-details-specialty-info" aria-label="Clinical Specialties" id="clinical-care-clinical-specialties"><h4 class="profile-details-specialty-info__header">Clinical Specialties</h4><div class="profile-details-specialty-info__specialties">Dermatology; Pediatric Dermatology</div></section></div></div></section><section class="profile-details-content-section" aria-label="clinicalCare Fact Sheets" id="clinical-care-fact-sheets" tabindex="-1"><h3 class="profile-details-content-section__heading">Fact Sheets</h3><div class="profile-details-content-section__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-fact-sheet-card" aria-label="Psoriasis"><h4><span class="profile-details-fact-sheet-card__title">Psoriasis</span></h4><a href="https://www.yalemedicine.org/conditions/psoriasis" class="profile-details-fact-sheet-card__link" aria-label="Read more on YM about Psoriasis" target="_blank"><span class="profile-details-ym-card-link-content"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 557.83 268.15" focusable="false" class="profile-details-ym-card-link-content__ym-icon"><path d="M557.83 268.15V0h-34.57L432.4 223.12 341.14 0h-34.17v268.15h22.92V28.95l98.09 239.2h8.84l97.69-239.2v239.2zM118.39.1H0v11c23.6 1.69 35.39 8.43 47.62 28.65l70.77 119.66v81.31c-6.32 12.64-29.91 15.59-49.29 16.44v10.94h136.08v-10.99c-19.38-.85-39.61-3.37-47.61-22.34V156l69.52-117.14c11.8-19.38 26.12-27 48.88-27.81V.1H174.85v11C197.17 12.31 206 17 212.77 22l-64.46 113.35L82.58 21.59c6.32-5.06 13.48-9.28 35.81-10.54Z" style="fill:currentColor"></path></svg><span class="profile-details-ym-card-link-content__content">Learn More on Yale Medicine</span><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-ym-card-link-content__arrow-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-fact-sheet-card" aria-label="Eczema"><h4><span class="profile-details-fact-sheet-card__title">Eczema</span></h4><a href="https://www.yalemedicine.org/conditions/eczema" class="profile-details-fact-sheet-card__link" aria-label="Read more on YM about Eczema" target="_blank"><span class="profile-details-ym-card-link-content"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 557.83 268.15" focusable="false" class="profile-details-ym-card-link-content__ym-icon"><path d="M557.83 268.15V0h-34.57L432.4 223.12 341.14 0h-34.17v268.15h22.92V28.95l98.09 239.2h8.84l97.69-239.2v239.2zM118.39.1H0v11c23.6 1.69 35.39 8.43 47.62 28.65l70.77 119.66v81.31c-6.32 12.64-29.91 15.59-49.29 16.44v10.94h136.08v-10.99c-19.38-.85-39.61-3.37-47.61-22.34V156l69.52-117.14c11.8-19.38 26.12-27 48.88-27.81V.1H174.85v11C197.17 12.31 206 17 212.77 22l-64.46 113.35L82.58 21.59c6.32-5.06 13.48-9.28 35.81-10.54Z" style="fill:currentColor"></path></svg><span class="profile-details-ym-card-link-content__content">Learn More on Yale Medicine</span><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-ym-card-link-content__arrow-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-fact-sheet-card" aria-label="Allergic Contact Dermatitis"><h4><span class="profile-details-fact-sheet-card__title">Allergic Contact Dermatitis</span></h4><a href="https://www.yalemedicine.org/conditions/dermatitis" class="profile-details-fact-sheet-card__link" aria-label="Read more on YM about Allergic Contact Dermatitis" target="_blank"><span class="profile-details-ym-card-link-content"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 557.83 268.15" focusable="false" class="profile-details-ym-card-link-content__ym-icon"><path d="M557.83 268.15V0h-34.57L432.4 223.12 341.14 0h-34.17v268.15h22.92V28.95l98.09 239.2h8.84l97.69-239.2v239.2zM118.39.1H0v11c23.6 1.69 35.39 8.43 47.62 28.65l70.77 119.66v81.31c-6.32 12.64-29.91 15.59-49.29 16.44v10.94h136.08v-10.99c-19.38-.85-39.61-3.37-47.61-22.34V156l69.52-117.14c11.8-19.38 26.12-27 48.88-27.81V.1H174.85v11C197.17 12.31 206 17 212.77 22l-64.46 113.35L82.58 21.59c6.32-5.06 13.48-9.28 35.81-10.54Z" style="fill:currentColor"></path></svg><span class="profile-details-ym-card-link-content__content">Learn More on Yale Medicine</span><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-ym-card-link-content__arrow-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></article></li><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white profile-details-fact-sheet-card" aria-label="Actinic Keratosis (AK)"><h4><span class="profile-details-fact-sheet-card__title">Actinic Keratosis (AK)</span></h4><a href="https://www.yalemedicine.org/conditions/actinic-keratosis" class="profile-details-fact-sheet-card__link" aria-label="Read more on YM about Actinic Keratosis (AK)" target="_blank"><span class="profile-details-ym-card-link-content"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 557.83 268.15" focusable="false" class="profile-details-ym-card-link-content__ym-icon"><path d="M557.83 268.15V0h-34.57L432.4 223.12 341.14 0h-34.17v268.15h22.92V28.95l98.09 239.2h8.84l97.69-239.2v239.2zM118.39.1H0v11c23.6 1.69 35.39 8.43 47.62 28.65l70.77 119.66v81.31c-6.32 12.64-29.91 15.59-49.29 16.44v10.94h136.08v-10.99c-19.38-.85-39.61-3.37-47.61-22.34V156l69.52-117.14c11.8-19.38 26.12-27 48.88-27.81V.1H174.85v11C197.17 12.31 206 17 212.77 22l-64.46 113.35L82.58 21.59c6.32-5.06 13.48-9.28 35.81-10.54Z" style="fill:currentColor"></path></svg><span class="profile-details-ym-card-link-content__content">Learn More on Yale Medicine</span><svg xmlns="http://www.w3.org/2000/svg" viewBox="0 0 24 24" focusable="false" class="profile-details-ym-card-link-content__arrow-icon"><path d="M23.25 12.497H.75M19.5 16.247l3.75-3.75-3.75-3.75" style="fill:none;stroke:currentColor;stroke-linecap:round;stroke-linejoin:round;stroke-width:1.5px"></path></svg></span></a></article></li></ul><div class="profile-details-see-all-button profile-details-see-all-button--width-mode--large"><div class="profile-details-see-all-button__wrapper"><a href="https://www.yalemedicine.org/search/conditions?entityType=Specialist&entityId=67767&q=Keith+Choate" tabindex="0" class="button button--large button--secondary button--color-mode--yale-blue button--link button-with-icon"><span class="button__label">See All Fact Sheets On Yale Medicine</span><span class="button__icon" aria-hidden="true"><svg xmlns="http://www.w3.org/2000/svg" data-name="Layer 1" viewBox="0 0 557.83 268.15" focusable="false" class="profile-details-see-all-button__icon"><path d="M557.83 268.15V0h-34.57L432.4 223.12 341.14 0h-34.17v268.15h22.92V28.95l98.09 239.2h8.84l97.69-239.2v239.2zM118.39.1H0v11c23.6 1.69 35.39 8.43 47.62 28.65l70.77 119.66v81.31c-6.32 12.64-29.91 15.59-49.29 16.44v10.94h136.08v-10.99c-19.38-.85-39.61-3.37-47.61-22.34V156l69.52-117.14c11.8-19.38 26.12-27 48.88-27.81V.1H174.85v11C197.17 12.31 206 17 212.77 22l-64.46 113.35L82.58 21.59c6.32-5.06 13.48-9.28 35.81-10.54Z" style="fill:currentColor"></path></svg></span></a></div></div></div></section><section class="profile-details-content-section" aria-label="clinicalCare Board Certifications" id="clinical-care-board-certifications" tabindex="-1"><h3 class="profile-details-content-section__heading">Board Certifications</h3><div class="profile-details-content-section__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><article class="profile-details-card profile-details-card--color-mode--white" aria-label="Board Certification Dermatology"><h4 class="profile-details-board-certification-card__specialty">Dermatology</h4><dl class="profile-details-board-certification-card__container"><dt class="profile-details-board-certification-card__label">Certification Organization</dt><dd class="profile-details-board-certification-card__info">AB of Dermatology</dd></dl><dl class="profile-details-board-certification-card__container"><dt class="profile-details-board-certification-card__label">Original Certification Date</dt><dd class="profile-details-board-certification-card__info">2008</dd></dl></article></li></ul></div></section><section class="profile-details-content-section" aria-label="clinicalCare Yale Medicine News" id="clinical-care-yale-medicine-news" tabindex="-1"><h3 class="profile-details-content-section__heading">Yale Medicine News</h3><div class="profile-details-content-section__content"><ul class="profile-details-column-list profile-details-column-list--gap-mode--normal profile-details-column-list--gap-mode-on-desktop--normal profile-details-column-list--gap-mode-on-tablet--normal profile-details-column-list--gap-mode-on-mobile--normal profile-details-column-list--columns-on-desktop--2 profile-details-column-list--columns-on-tablet--2 profile-details-column-list--columns-on-mobile--1"><li class="profile-details-column-list-item"><a href="https://www.yalemedicine.org/news/2024-top-doctors-list-yale-medicine-physicians" class="profile-details-ym-news-link" target="_blank"><span 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class="profile-list__item-container"><li class="profile-list__item profile-list__item--type--profile-list profile-list__item--size-mode--large profile-list__item--with-first-item-top-border"><div class="profile-detailed-info-list-item profile-detailed-info-list-item--link"><div class="profile-detailed-info-list-item__content-container"><a href="/profile/sheila-garcia/" aria-label="Sheila Garcia" class="profile-detailed-info-list-item__content"><div class="profile-detailed-info-list-item__thumbnail-wrapper"><span class="" style="display:inline-block"></span></div><div class="profile-detailed-info-list-item__info"><span class="profile-detailed-info-list-item__name">Sheila Garcia</span><div class="LinesEllipsis text-overflow profile-detailed-info-list-item__title">Chief of Staff/Office Manager DERM Chair's Office<wbr/></div></div></a></div></div></li></ul></div></div></div></section><section class="profile-details-content-section" aria-label="getInTouch Locations" 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Medicine","websiteUrl":"https://medicine.yale.edu/about/deanoffice/"},{"id":71622,"title":"Professor","type":"Primary","organizationName":"Dermatology","websiteUrl":"https://medicine.yale.edu/dermatology/"},{"id":81971,"title":"Professor","type":"Secondary","organizationName":"Genetics","websiteUrl":"https://medicine.yale.edu/genetics/"},{"id":81938,"title":"Professor","type":"Secondary","organizationName":"Pathology","websiteUrl":"https://medicine.yale.edu/pathology/"}],"organizations":[{"id":116433,"name":"Dean's Advisory Council for LGBTQI Affairs","url":"https://medicine.yale.edu/lgbtqi/"},{"id":108737,"name":"Dermatology","url":"https://medicine.yale.edu/dermatology/"},{"id":116603,"name":"Directories","url":null},{"id":108854,"name":"Genetics","url":"https://medicine.yale.edu/genetics/"},{"id":110442,"name":"Genomics, Genetics, and Epigenetics","url":"https://www.yalecancercenter.org/research/programs/genetics/"},{"id":109152,"name":"Medical Dermatology","url":"https://medicine.yale.edu/dermatology/"},{"id":109539,"name":"Molecular Cell Biology, Genetics and Development","url":"https://medicine.yale.edu/bbs/tracks/molecular-cell-biology-genetics-development/"},{"id":110408,"name":"Molecular Medicine, Pharmacology, and Physiology","url":"https://medicine.yale.edu/bbs/tracks/translational-molecular-medicine-pharmacology-physiology/"},{"id":109079,"name":"Office of the Dean, School of Medicine","url":"https://medicine.yale.edu/about/deanoffice/"},{"id":122725,"name":"Palade House Affiliates","url":"https://medicine.yale.edu/md-program/student-affairs/academic-career-advising-advisory-houses/advisory-houses/palade/"},{"id":108738,"name":"Pathology","url":"https://medicine.yale.edu/pathology/"},{"id":115339,"name":"Pathology and Molecular Medicine","url":"https://medicine.yale.edu/pathology/training/graduateprogram/"},{"id":110385,"name":"Pathology Research","url":"https://medicine.yale.edu/pathology/research/researchers/"},{"id":109274,"name":"Pediatric Dermatology","url":"https://medicine.yale.edu/dermatology/"},{"id":121171,"name":"Program in Translational Biomedicine (PTB)","url":null},{"id":121275,"name":"Psoriasis Treatment Program","url":null},{"id":109631,"name":"Yale Cancer Center","url":"https://www.yalecancercenter.org/"},{"id":119354,"name":"Yale Center for Genomic Health","url":"https://medicine.yale.edu/ycgh/"},{"id":109532,"name":"Yale Combined Program in the Biological and Biomedical Sciences (BBS)","url":"https://medicine.yale.edu/bbs/"},{"id":109237,"name":"Yale Dermatology Associates","url":"https://www.yalemedicine.org/departments/dermatology"},{"id":110193,"name":"Yale Medicine","url":"https://www.yalemedicine.org/"},{"id":116604,"name":"Yale Medicine Outlist","url":"https://medicine.yale.edu/lgbtqi/medicineoutlist/"},{"id":109569,"name":"Yale Stem Cell Center","url":"https://medicine.yale.edu/stemcell/"},{"id":114820,"name":"Yale Ventures","url":"https://ventures.yale.edu/"}],"educations":[{"degree":"Resident","institution":"Yale- New Haven Hospital (2008)","dateAwarded":"2008-06-30T00:00:00Z","isTraining":true},{"degree":"Postdoctoral Fellow","institution":"Yale University School of Medicine (2008)","dateAwarded":"2008-06-30T00:00:00Z","isTraining":true},{"degree":"Intern","institution":"Yale-New Haven Hospital (2005)","dateAwarded":"2005-06-01T00:00:00Z","isTraining":true},{"degree":"MD","institution":"Yale University School of Medicine (2004)","dateAwarded":"2004-01-01T00:00:00Z","isTraining":false},{"degree":"PhD","institution":"Yale University, Cell Biology (2001)","dateAwarded":"2001-05-14T00:00:00Z","isTraining":false},{"degree":"MPhil","institution":"Yale University, Cell Biology (2000)","dateAwarded":"2000-12-15T00:00:00Z","isTraining":false},{"degree":"BS","institution":"Stanford University, Biological Sciences (1995)","dateAwarded":"1995-01-01T00:00:00Z","isTraining":false}],"advancedTrainings":[],"sectionType":"about"},{"config":{"layoutType":"default","statement":null,"quote":null,"stats":{"clinicalTrialInfo":{"openToAccrualClinicalTrialsCount":1,"searchUrl":"/ysm/search/?entityType=ClinicalTrial&status=OpenToAccrual&profilePageName=keith-choate"},"publicationInfo":{"publicationsCount":67,"citationsCount":4228,"coAuthorsCount":25,"searchUrl":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate"}}},"displayMode":"default","pageName":"keith-choate","fullName":"Keith Choate","researchDescription":"<p xmlns=\"http://www.w3.org/1999/xhtml\">Genetics has informed our understanding of normal skin development and differentiation, largely due to the fact that mutations affecting the skin result in easily observed phenotypes.  Genetic investigation has permitted us to identify <em>a priori </em>pathways previously unrecognized to be relevant to skin biology.  These insights have been relevant to diagnosis, disease prevention, and development of novel therapeutics. </p><p xmlns=\"http://www.w3.org/1999/xhtml\"> \n </p><p xmlns=\"http://www.w3.org/1999/xhtml\">We have three ongoing projects in the lab:\n </p><p xmlns=\"http://www.w3.org/1999/xhtml\"> 1. Identification of novel genetic causes of inherited skin disorders including ichthyosis, inflammatory disorders and alopecia.  We have developed one of the largest registries of kindreds with ichthyosis and have identified over 10 new genetic cause of this group of disorders – we employ cell, murine, and engineered tissue models to understand that biological basis of disease and the role of novel genes in disease pathobiology.</p><p xmlns=\"http://www.w3.org/1999/xhtml\"> 2. Identification of novel genetic causes of mosaic skin disorders including childhood malformations, vascular tumors, and linear presentations of inflammatory disorders.  Mosaic disorders are the result of embryonic somatic mutation, with timing of mutation determining the extent of disease.  Among other discoveries, we have systematically dissected pathways leading to development of aggressive infantile vascular tumors, identified novel causes of acne pathogenesis and hair follicle differentiation, and have identified Ras as a regulator of phosphate homeostasis.  A new project is focused on linear manifestation of common inflammatory disorders such as lupus, psoriasis, and lichen planus with the expectation that investigation will identify novel pathways in cutaneous innate immunity.</p><p xmlns=\"http://www.w3.org/1999/xhtml\"> 3. Elucidation of mechanisms of revertant mosaicism in ichthyosis with confetti to enable therapeutic recombination in the skin.  We have found that specific mutations in <em>KRT1</em> and <em>KRT10</em> cause ichthyosis with confetti which undergoes spontaneous self-correction via revertant mosaicism, resulting in hundreds to thousands of patches of normal skin.  All spots arise from mitotic recombination, and have found that keratin mutations directly influence DNA damage and repair and that cellular competition favors reversion.  We are employing forward genetics to identify the pathways relevant to recombination and competition.</p><p xmlns=\"http://www.w3.org/1999/xhtml\"> \n </p>","meshKeywords":[{"id":3425,"keyword":"Cell Biology"},{"id":5573,"keyword":"Genetics"},{"id":5575,"keyword":"Genetics, Medical"},{"id":28814,"keyword":"Human Genetics"},{"id":15187,"keyword":"Human Genome Project"},{"id":6743,"keyword":"Ichthyosis"},{"id":8628,"keyword":"Mosaicism"},{"id":16350,"keyword":"Skin and Connective Tissue Diseases"},{"id":12313,"keyword":"Skin Diseases"}],"publicationListing":{"collection":[{"category":"Peer-Reviewed Original Research","pubMedUid":39278313,"doi":"10.1016/j.jaad.2024.08.063","altmetricAttentionScore":1,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"710534^0","title":"Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database","citation":"Curtis K, Echeandia-Francis C, Falotico J, Luo A, Qiu Y, Grover C, Piraccini B, <strong data-id=\"67767\">Choate K</strong>, Lipner S. Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database. Journal Of The American Academy Of Dermatology 2024 <a href=\"https://pubmed.ncbi.nlm.nih.gov/39278313\" target=\"_blank\">PMID: 39278313</a>, <a href=\"https://doi.org/10.1016/j.jaad.2024.08.063\" target=\"_blank\">DOI: 10.1016/j.jaad.2024.08.063</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39278313","text":"Retrospective analysis of nail findings in the National Registry for Ichthyosis and Related Disorders database"}},{"category":"Peer-Reviewed Original Research","pubMedUid":null,"doi":"10.1016/j.jid.2024.06.1150","altmetricAttentionScore":0,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[],"id":"704930^0","title":"LB974 Mutation spectrum of cutaneous vascular anomalies","citation":"shah K, Goldust M, Ellis K, Ugwu N, Hu R, <span data-id=\"59193\">Zhou J</span>, <strong data-id=\"67767\">Choate K</strong>. LB974 Mutation spectrum of cutaneous vascular anomalies. Journal Of Investigative Dermatology 2024, 144: s171. <a href=\"https://doi.org/10.1016/j.jid.2024.06.1150\" target=\"_blank\">DOI: 10.1016/j.jid.2024.06.1150</a>.","year":2024,"link":{"url":"https://doi.org/10.1016/j.jid.2024.06.1150","text":"LB974 Mutation spectrum of cutaneous vascular anomalies"}},{"category":"Peer-Reviewed Original Research","pubMedUid":39060641,"doi":"10.1038/s44321-024-00104-3","altmetricAttentionScore":1,"timesCited":0,"isFeatured":false,"keywords":[],"concepts":[{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Darier%27s%20disease","text":"Darier's disease"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20stress","text":"ER stress"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cell%20adhesion","text":"Cell adhesion"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20calcium%20levels","text":"ER calcium levels"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Upregulation%20of%20ER%20stress","text":"Upregulation of ER stress"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Inhibited%20calcium%20release","text":"Inhibited calcium release"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Ryanodine%20receptor%20antagonist","text":"Ryanodine receptor antagonist"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Endoplasmic%20reticulum%20calcium%20homeostasis","text":"Endoplasmic reticulum calcium homeostasis"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Target%20pathogenic%20mechanisms","text":"Target pathogenic mechanisms"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Features%20of%20Darier%27s%20disease","text":"Features of Darier's disease"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Identified%20dysregulated%20genes","text":"Identified dysregulated genes"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Mechanisms%20of%20DD","text":"Mechanisms of DD"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Non-dermatological%20indications","text":"Non-dermatological indications"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cellular%20calcium%20dynamics","text":"Cellular calcium dynamics"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Cellular%20functions","text":"Cellular functions"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ER%20calcium","text":"ER calcium"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Homeostasis%20pathways","text":"Homeostasis pathways"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=ATP2A2%20gene","text":"ATP2A2 gene"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=In%20vitro%20model","text":"In vitro model"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Receptor%20antagonist","text":"Receptor antagonist"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pumps%20calcium","text":"Pumps calcium"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Calcium%20release","text":"Calcium release"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Promote%20cell%20adhesion","text":"Promote cell adhesion"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Isoform%202","text":"Isoform 2"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Suppressed%20apoptosis","text":"Suppressed apoptosis"}],"id":"704950^0","title":"Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment","citation":"Hunt M, Wang N, Pupinyo N, Curman P, Torres M, Jebril W, Chatzinikolaou M, Lorent J, Silberberg G, Bansal R, Burner T, Zhou J, Kimeswenger S, Hoetzenecker W, <strong data-id=\"67767\">Choate K</strong>, Bachar-Wikstrom E, Wikstrom J. Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment. EMBO Molecular Medicine 2024, 16: 1986-2001. <a href=\"https://pubmed.ncbi.nlm.nih.gov/39060641\" target=\"_blank\">PMID: 39060641</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392931\" target=\"_blank\">PMCID: PMC11392931</a>, <a href=\"https://doi.org/10.1038/s44321-024-00104-3\" target=\"_blank\">DOI: 10.1038/s44321-024-00104-3</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/39060641","text":"Dantrolene corrects cellular disease features of Darier disease and may be a novel treatment"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38598229,"doi":"10.1001/jamadermatol.2024.0257","altmetricAttentionScore":9,"timesCited":2,"isFeatured":false,"keywords":[],"concepts":[{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Psoriasis%20Area%20Severity%20Index","text":"Psoriasis Area Severity Index"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pityriasis%20rubra%20pilaris","text":"Pityriasis rubra pilaris"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dermatology%20Life%20Quality%20Index%20scores","text":"Dermatology Life Quality Index scores"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Involvement%20of%20interleukins","text":"Involvement of interleukins"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Quality%20Index%20score","text":"Quality Index score"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Food%20and%20Drug%20Administration-approved%20treatment","text":"Food and Drug Administration-approved treatment"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Primary%20outcome","text":"Primary outcome"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=US%20Food%20and%20Drug%20Administration-approved%20treatment","text":"US Food and Drug Administration-approved treatment"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Psoriasis%20area%20severity%20index%20score","text":"Psoriasis area severity index score"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Sex-matched%20healthy%20controls","text":"Sex-matched healthy controls"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23p19%20inhibitors","text":"IL-23p19 inhibitors"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=P19%20subunit%20of%20IL-23","text":"P19 subunit of IL-23"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Index%20score","text":"Index score"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Area%20Severity%20Index","text":"Area Severity Index"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23%2FIL-17","text":"IL-23/IL-17"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Subunit%20of%20IL-23","text":"Subunit of IL-23"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Per-protocol%20analysis","text":"Per-protocol analysis"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20response","text":"Clinical response"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Study%20drug","text":"Study drug"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dosing%20schedule","text":"Dosing schedule"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20responders","text":"Clinical responders"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Clinical%20improvement","text":"Clinical improvement"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Male%20patients","text":"Male patients"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=IL-23","text":"IL-23"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Guselkumab","text":"Guselkumab"}],"id":"698061^0","title":"Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling","citation":"Velasco R, Shao C, Cutler B, Strunck J, Kent G, Cassidy P, <strong data-id=\"67767\">Choate K</strong>, Greiling T. Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling. JAMA Dermatology 2024, 160: 641-645. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38598229\" target=\"_blank\">PMID: 38598229</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007649\" target=\"_blank\">PMCID: PMC11007649</a>, <a href=\"https://doi.org/10.1001/jamadermatol.2024.0257\" target=\"_blank\">DOI: 10.1001/jamadermatol.2024.0257</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/38598229","text":"Guselkumab for Pityriasis Rubra Pilaris and Dysregulation of IL-23/IL-17 and NFkB Signaling"}},{"category":"Peer-Reviewed Case Reports and Technical Notes","pubMedUid":38952857,"doi":"10.1016/j.jdcr.2024.05.002","altmetricAttentionScore":0,"timesCited":1,"isFeatured":false,"keywords":[],"concepts":[],"id":"697933^0","title":"Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab","citation":"Singh K, Breidbart R, Jaiswal A, Damsky W, <strong data-id=\"67767\">Choate K</strong>, <span data-id=\"98502\">Vesely M</span>. Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab. JAAD Case Reports 2024, 49: 102-105. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38952857\" target=\"_blank\">PMID: 38952857</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11214983\" target=\"_blank\">PMCID: PMC11214983</a>, <a href=\"https://doi.org/10.1016/j.jdcr.2024.05.002\" target=\"_blank\">DOI: 10.1016/j.jdcr.2024.05.002</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/38952857","text":"Intravenous immunoglobulin-induced eczematous dermatitis treated with dupilumab"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38395493,"doi":"10.1016/j.jid.2023.10.007","altmetricAttentionScore":3,"timesCited":0,"isFeatured":false,"keywords":[{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=3710","text":"Dermatology"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=8628","text":"Mosaicism"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&keywordId=8746","text":"Mutation"}],"concepts":[],"id":"687616^0","title":"How Efforts to Understand Somatic Mosaicism Will Impact Dermatology","citation":"<span data-id=\"127642\">Mortlock R</span>, <strong data-id=\"67767\">Choate K</strong>. How Efforts to Understand Somatic Mosaicism Will Impact Dermatology. Journal Of Investigative Dermatology 2024, 144: 453-455. <a href=\"https://pubmed.ncbi.nlm.nih.gov/38395493\" target=\"_blank\">PMID: 38395493</a>, <a href=\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11009867\" target=\"_blank\">PMCID: PMC11009867</a>, <a href=\"https://doi.org/10.1016/j.jid.2023.10.007\" target=\"_blank\">DOI: 10.1016/j.jid.2023.10.007</a>.","year":2024,"link":{"url":"https://pubmed.ncbi.nlm.nih.gov/38395493","text":"How Efforts to Understand Somatic Mosaicism Will Impact Dermatology"}},{"category":"Peer-Reviewed Original Research","pubMedUid":38273779,"doi":"10.1111/pde.15523","altmetricAttentionScore":0,"timesCited":1,"isFeatured":false,"keywords":[],"concepts":[{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Schimmelpenning-Feuerstein-Mims","text":"Schimmelpenning-Feuerstein-Mims"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Sebaceous%20nevus","text":"Sebaceous nevus"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Downstream%20of%20KRAS","text":"Downstream of KRAS"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Schimmelpenning-Feuerstein-Mims%20syndrome","text":"Schimmelpenning-Feuerstein-Mims syndrome"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Oral%20trametinib","text":"Oral trametinib"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=MAPK%20signaling%20pathway","text":"MAPK signaling pathway"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Skin%20involvement","text":"Skin involvement"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Trametinib","text":"Trametinib"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Decreased%20pruritus","text":"Decreased pruritus"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Pathogenic%20variants","text":"Pathogenic variants"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Topical%20use","text":"Topical use"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Dermatological%20conditions","text":"Dermatological conditions"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Signaling%20pathway","text":"Signaling pathway"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=KRAS","text":"KRAS"},{"url":"/ysm/profile/keith-choate/academic-publications/?profilePageName=keith-choate&concept=Nevi","text":"Nevi"}],"id":"687612^0","title":"Topical trametinib for epidermal and sebaceous nevi in a child with Schimmelpenning‐Feuerstein‐Mims syndrome","citation":"Haller C, Leszczynska M, Brichta L, Maier E, Riddington I, <strong data-id=\"67767\">Choate K</strong>, Levy M. 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Associations between ichthyosis and mood disorders: A case-control study in the All of Us Research Program. Journal Of The American Academy Of Dermatology 2023, 90: 439-440. <a href=\\\"https://pubmed.ncbi.nlm.nih.gov/37863200\\\" target=\\\"_blank\\\">PMID: 37863200</a>, <a href=\\\"https://doi.org/10.1016/j.jaad.2023.10.025\\\" target=\\\"_blank\\\">DOI: 10.1016/j.jaad.2023.10.025</a>.\",\"@context\":\"http://schema.org\"}"}]}}],"sidebarComponents":[],"contextNavigation":null}</script> <script>window['applicationSettings'] = {"shouldShowSuppressedImageWarnings":false,"shouldShowBugReportButton":false,"shouldShowDownloadAsWordButton":false,"captchaKey":"a46dfca5-98da-4ec7-83e2-16980be648d0","facebookShareUrl":"https://www.facebook.com/dialog/share?app_id=604142276782606&display=popup&href=","isSearchFeedbackEnabled":true,"isSearchAnalyticsEnabled":true,"siteimproveScriptUrl":"https://siteimproveanalytics.com/js/siteanalyze_373.js","radarKey":"prj_live_pk_e9bc38cc9ac871b02332c0d599d7a893c03ad94d","mediaStatistics":{"baseUrl":"https://media-statistics-prod.ysmdevs.com","apiKey":"249c64e3-d0cc-45ed-97a0-5d3106411485","isEnabled":true}};</script> <noscript id="modern__LOADABLE_REQUIRED_CHUNKS__">[4589,7640,6443,4480,6736,6293,5666,8707,6325,1739,8404,2944,3053]</noscript><noscript id="modern__LOADABLE_REQUIRED_CHUNKS___ext">{"namedChunks":["modules-page-components-ComponentWrapper","modules-profile-components-profile-details-ProfileDetails","modules-footer-components-Footer"]}</noscript> <script async data-chunk="main" src="https://cdn1.medicine.yale.edu/build/main.es2015.e71226adbc7ac9e6afaf.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4589.es2015.4c47bf8350b6c4f009a0.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/7640.es2015.305f7f9c55b908f8d7a2.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6443.es2015.4890cbc400a8796edee4.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/4480.es2015.473ffd08eabb889a822c.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6736.es2015.36fcc1e83004e7c6188d.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6293.es2015.a955a43c28f0a24dd4fa.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/5666.es2015.f47cd983c67020627178.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/8707.es2015.0f85929e46010fd82776.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/6325.es2015.3731caff209d628cedac.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/1739.es2015.9ce9a21bd840865df3b8.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/8404.es2015.44ae95a8c2402548bad5.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-profile-components-profile-details-ProfileDetails" src="https://cdn1.medicine.yale.edu/build/2944.es2015.ac9b45323eabedf3adb7.js" type="module" crossorigin="anonymous"></script> <script async data-chunk="modules-footer-components-Footer" src="https://cdn1.medicine.yale.edu/build/3053.es2015.404cba0e717f410cb74c.js" type="module" crossorigin="anonymous"></script> <link rel="stylesheet" href="https://use.typekit.net/eqf4dwf.css" as="style" crossorigin>  <script async type="text/plain" data-cookiecategory="analytics" src="https://siteimproveanalytics.com/js/siteanalyze_373.js"></script> </body> </html>

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Keith Choate, MD, PhD < Yale School of Medicine