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Diagnostic Challenges and Approaches in Pediatric Anemia – Neonatal Disorders
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class="site-content" id="content"> <div class="content-area" id="primary"> <main class="site-main" id="main"> <article id="post-72" class="post-72 post type-post status-publish format-standard has-post-thumbnail hentry category-pediatric-anemia tag-chronic-diseases tag-genetic-disorders tag-malnutrition tag-microcytic-anemia tag-nutritional-deficiencies tag-pediatric-anemia" itemtype="https://schema.org/CreativeWork" itemscope> <div class="inside-article"> <div class="featured-image page-header-image-single "> <img width="2560" height="1340" src="https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-scaled.jpg" class="attachment-full size-full" alt="" itemprop="image" decoding="async" fetchpriority="high" srcset="https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-scaled.jpg 2560w, https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-300x157.jpg 300w, https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-1024x536.jpg 1024w, https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-768x402.jpg 768w, https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-1536x804.jpg 1536w, https://neonataldisorders.com/archive/wp-content/uploads/2024/09/Diagnostic-Challenges-32-min-2048x1072.jpg 2048w" sizes="(max-width: 2560px) 100vw, 2560px" /> </div> <header class="entry-header"> <h1 class="entry-title" itemprop="headline">Diagnostic Challenges and Approaches in Pediatric Anemia</h1> <div class="entry-meta"> <span class="posted-on"><time class="updated" datetime="2024-09-06T23:37:24+05:30" itemprop="dateModified">September 6, 2024</time><time class="entry-date published" datetime="2024-09-03T18:16:28+05:30" itemprop="datePublished">September 3, 2024</time></span> <span class="byline">by <span class="author vcard" itemprop="author" itemtype="https://schema.org/Person" itemscope><a class="url fn n" href="https://neonataldisorders.com/archive/author/neonataldisorders/" title="View all posts by neonataldisorders" rel="author" itemprop="url"><span class="author-name" itemprop="name">neonataldisorders</span></a></span></span> </div> </header> <div class="entry-content" itemprop="text"> <p><span style="font-weight: 400;">Moreover, anemia in children is diagnosed as a multifactorial disease and can be closely related to several diseases, which means that the diagnosis of anemia is very difficult for clinicians and other healthcare professionals. The causes of childhood anemia include nutritional deficiencies, genetic disorders, chronic diseases, infections, and many more. Understanding the etiology on which intervention is based may sometimes call for a comprehensive investigation, possibly a history, a clinical, and several investigations. When diagnosing anemia in children, there are unique difficulties that stem from the fact that children may present a variety of anemias that will have quite similar symptoms to other diseases, and therefore, there is a need to approach the diagnosis systematically to avoid a wrong diagnosis or treatment.</span><span style="font-weight: 400;"> </span></p> <h3><b>Understanding the Basics of Pediatric Anemia</b></h3> <p><span style="font-weight: 400;">Pediatric anemia involves a decrease in RBC count or morphological concentration, which influences the blood’s ability to transport oxygen. Some patients may present with symptoms such as tiredness, pale skin, muscle weakness, and easily becoming annoyed. Although malnutrition, especially iron deficiency anemia, remains the primary etiology for anemia, other contributing conditions, such as those outlined above, are also frequent. </span></p> <h3><b>Nutritional Deficiencies and Anemia </b></h3> <p><span style="font-weight: 400;">The commonest cause of anemia resulting from nutritional deficiency in this group of children is iron deficiency. They are commonly caused by malnutrition, malabsorption, or increased demand at times of growth. Thus, distinguishing the condition as IDA from other types of anemia can be intricate. For example, individuals with the Thalassemia trait may come with microcytic anemia resembling IDA or even have hemochromatosis that produces symptoms that are akin to the disease. Some other deficiencies can also lead to megaloblastic anemia; these are vitamin B12 and folate deficiencies, which cause large RBCs.</span></p> <h3><b> </b><b>Genetic Factors and Hemoglobinopathies </b><b> </b></h3> <p><span style="font-weight: 400;">Among the congenital anemia diseases that commonly affect children, hemoglobinopathies include sickle cell anemia and thalassemia. They are primarily expressed through such characteristics as chronic anemia and acute complications’ relapses. For instance, sickle cell disease is characterized by pain crises and organ issues because of the deformation of red blood cells. These are normally diagnosed using genes, and to ascertain if the patient has certain kinds of irregular hemoglobin, a test called hemoglobin electrophoresis is normally carried out by the doctor. Such complications, if recognized at a young age, would then enable one to properly manage the conditions to add to the lives of those young ones.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Yearwise Publication Trend on <b>“<a href="https://neonataldisorders.com/publication-trends/index/pediatric anemia" target="_blank" title="pediatric anemia - yearwise publication trends">pediatric anemia</a>”</b></h2> </div> </div><div class="results-container"><div class="chart-block" style="padding:15px;"> <div class="left"> <div id="results" class="results"></div> </div> <div class="right"> <div class="chart-container"><canvas id="publicationChart"></canvas></div> </div> <div class="keywordsdiv"> <div style="text-align:center;"><b>Find publication trends on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 4.687 11.314l224 224c6.248 6.248 16.378 6.248 22.626 0l176-176c6.244-6.244 6.25-16.364.013-22.615l-223.5-224A15.999 15.999 0 00196.5 39.5H20zm56 96c0-13.255 10.745-24 24-24s24 10.745 24 24-10.745 24-24 24-24-10.745-24-24z"></path><path d="M259.515 43.015c4.686-4.687 12.284-4.687 16.97 0l228 228c4.686 4.686 4.686 12.284 0 16.97l-180 180c-4.686 4.687-12.284 4.687-16.97 0-4.686-4.686-4.686-12.284 0-16.97L479.029 279.5 259.515 59.985c-4.686-4.686-4.686-12.284 0-16.97z"></path></svg></span> <span id="keyword-stats"></span> </div> </div></div></div><div class="inside-article"><style> table { margin: 0 0 1.5em; 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This category encompasses autoimmune hemolytic anemia (AIHA), a disease precipitated by autoantibodies in the context of RBC destruction. Testing for AIHA involves the performance of the direct antiglobulin test (DAT), in which the clinician checks for antibodies that are bound to RBCs. However, in some situations, patients with AIHA can have a negative DAT, which adds to the problem of diagnosis. The other causes of hemolytic anemia, like enzyme deficiencies, for example, glucose-6-phosphate dehydrogenase, or membrane defects, for instance, hereditary spherocytosis, have more distinct diagnostic procedures. </span></p> <h3><b>Chronic Diseases and Anemia </b><b> </b></h3> <p><span style="font-weight: 400;">ACA is mainly observed in patients with chronic diseases such as chronic kidney disease (CKD), inflammatory bowel disease (IBD), and chronic infections. ACD entails the body’s failure to properly mobilize stored iron for utilization, and this mostly results from high levels of hepcidin, a hormone that controls iron. The diagnosis of ACD requires the assessment of markers of inflammation and iron studies, which include serum ferritin and transferrin saturation. The approach to treating anemia in patients with chronic disorders is therapeutic, with the primary focus being the underlying disease process. In certain cases, agents such as erythropoiesis-stimulating agents, iron, or both may also be administered. </span></p> <h3><b>Infections and Anemia </b><b> </b></h3> <p><span style="font-weight: 400;">Infections either result in anemia due to the destruction of bone marrow tissue or by enhancing the rates of destruction of red blood cells or poor absorption of nutrients vital in the production of red blood cells. For example, malaria as a disease has been identified as a primary risk factor that predisposes clients from malaria-endemic regions to HA. The diagnosis of infection-associated anemia can be made by demonstrating the precipitating organism by blood examination, culture, or molecular biology. When infection is anticipated but a focus cannot be isolated, antimicrobial therapy could be initiated based on the clinician’s expectations.</span></p> <h3><b>Diagnostic Approach to Pediatric Anemia</b></h3> <p><span style="font-weight: 400;">Doctors take these steps to diagnose pediatric anemia:</span><span style="font-weight: 400;"> </span></p> <p><span style="font-weight: 400;">Detailed Patient History: Doctors need to get a full picture of the patient’s background. This covers what the child eats, any past issues with anemia or genetic problems, recent infections, medicines taken, and contact with harmful substances. Questions about growth patterns, development, and the child’s age can also give useful clues.</span></p> <p><span style="font-weight: 400;">Physical Examination: An energy, facial, and abdominal palpation, or a complete physical examination, can be a sign of some types of anemia. For example, jaundice might point to hemolysis, whereas petechiae and bruising might relate to bone marrow dysfunction. Abnormal physical features may suggest why anemia is present in some patients, and this may be caused by syndromes.</span></p> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Recent Publications on <b>“<a href="https://neonataldisorders.com/recent-publications/index/pediatric anemia" target="_blank" rel="noopener" title="pediatric anemia - yearwise publication list">pediatric anemia</a>”</b></h2> </div> </div> <div class="pb-main"><div class="article-scroll"><div id="results_recent" class="results"></div></div><div class="keywordsdiv" style="margin: 0px 15px;margin-top:20px;"> <div style="text-align:center;"><b>Find publications on relevant topics</b> </div> <span class="gp-icon icon-tags"><svg viewBox="0 0 512 512" aria-hidden="true" xmlns="http://www.w3.org/2000/svg" width="1em" height="1em"><path d="M20 39.5c-8.836 0-16 7.163-16 16v176c0 4.243 1.686 8.313 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// function stripslashes(str) { // if (typeof str === 'string') { // return str.replace(/\/g, ''); // } // } </script></p> <h3><b>Laboratory Tests</b></h3> <p><span style="font-weight: 400;">Complete Blood Count (CBC): The CBC has an influence on key data about hemoglobin levels, RBC indices (mean corpuscular volume, mean corpuscular hemoglobin), and reticulocytosis presence.</span></p> <p><span style="font-weight: 400;">Peripheral Blood Smear: Looking at RBC shapes can help spot specific anemia types, like spherocytes in hereditary spherocytosis or sickled cells in sickle cell disease.</span></p> <p><span style="font-weight: 400;">Iron Studies: Serum ferritin, transferrin saturation, and serum iron levels help tell apart iron deficiency anemia from anemia of chronic disease.</span></p> <p><span style="font-weight: 400;">Vitamin Levels: Checking serum vitamin B12 and folate levels can diagnose megaloblastic anemia.</span></p> <p><span style="font-weight: 400;">Hemoglobin Electrophoresis: This test is done to detect abnormal hemoglobin variants or when blood tests indicate that there could be an abnormal hemoglobinopathy.</span></p> <p><span style="font-weight: 400;">Examination of the Bone Marrow: In the event that bone marrow failure syndromes are suspected to be the cause, then the doctor may wish to have a bone marrow biopsy performed to check on cellularity and find any abnormal cells.</span></p> <p><span style="font-weight: 400;">Specialized Tests: Other tests may be necessary depending on the clinical situation. These may include enzyme assays for the detection of G6PD deficiency, gene studies for thalassemias, or immunologic tests for AIHA.</span></p> <h3><b>Challenges of Diagnosing Pediatric Anemia</b></h3> <p><span style="font-weight: 400;">The diagnosis of pediatric anemia is clouded by several complicating factors:</span></p> <p><span style="font-weight: 400;">Overlapping Symptoms: Many forms of anemia present with similar symptoms and are difficult to distinguish based solely on clinical presentation.</span><span style="font-weight: 400;"><br /> </span></p> <p><span style="font-weight: 400;">Variable Presentation: Conditions like thalassemia vary in their degree of severity, even within members of the same family, which makes diagnosis very challenging.</span><span style="font-weight: 400;"><br /> </span></p> <p><span style="font-weight: 400;">Age-Related Differences: The etiology and features of anemia can vary significantly among infants, young children, and adolescents.</span><span style="font-weight: 400;"><br /> </span></p> <p><span style="font-weight: 400;">Limited Resources: In a resource-poor setting, access to specialized tests and state-of-the-art diagnostic facilities may be unavailable, and thus medical judgment along with a few fundamental laboratory tests is all one can rely on.</span></p> <h3><b>Emerging Diagnostic Technologies</b></h3> <p><span style="font-weight: 400;">Advancing diagnostic technologies enhances accuracy and efficiency in the diagnosis of pediatric anemia.</span></p> <p><span style="font-weight: 400;">Genetic Testing: Next-generation sequencing and other genetic tests are increasingly being applied to identify responsible mutations. For example, hereditary anemia can be clearly diagnosed by such technologies, which leads to targeted therapies.</span><span style="font-weight: 400;"><br /> </span></p> <p><span style="font-weight: 400;">Point-of-Care Testing: Easy access to portable devices for measuring hemoglobin or other blood parameters will increase the chance of early diagnosis and management, especially in peripheral settings.</span></p> <p><span style="font-weight: 400;">Biomarkers: Some new biomarkers are under study for the characterization of various anemias that may lead to more specific and less invasive diagnostic methods.</span></p> <h3><b>Conclusion</b></h3> <p><span style="font-weight: 400;">The diagnosis of anemia in children is complex and requires an understanding of the varied causes along with a systematic approach to workup. Integrate information gleaned from the patient’s history, physical examination, and a host of laboratory tests, and the healthcare provider has an excellent likelihood of identifying the correct etiology of the anemia and instituting appropriate treatment. Improvement in diagnostic technologies and a better understanding of the pathophysiology of anemia will further enhance our ability to manage this common but complex condition in children.</span></p> <p></p> <h3><b>References</b></h3> <ol> <li>Green, R. and Dwyre, D.M., 2015, October. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0037196315000554">Evaluation of macrocytic anemias</a>. In <i>Seminars in hematology</i> (Vol. 52, No. 4, pp. 279-286). WB Saunders.</li> <li> <div class="citation-text">Grace RF, Zanella A, Neufeld EJ, Morton DH, Eber S, Yaish H, Glader B. <a href="https://pubmed.ncbi.nlm.nih.gov/26087744/">Erythrocyte pyruvate kinase deficiency: 2015 status report.</a> Am J Hematol. 2015 Sep;90(9):825-30. doi: 10.1002/ajh.24088. Epub 2015 Aug 14. PMID: 26087744; PMCID: PMC5053227.</div> </li> <li> <div class="citation-text">Fishbane SN, Singh AK, Cournoyer SH, Jindal KK, Fanti P, Guss CD, Lin VH, Pratt RD, Gupta A. Ferric <a href="https://pubmed.ncbi.nlm.nih.gov/26175145/">pyrophosphate citrate (Triferic™) administration via the dialysate maintains hemoglobin and iron balance in chronic hemodialysis patients.</a> Nephrol Dial Transplant. 2015 Dec;30(12):2019-26. doi: 10.1093/ndt/gfv277. Epub 2015 Jul 13. PMID: 26175145; PMCID: PMC4656038.</div> </li> <li> <div class="citation-text">Piel FB, Weatherall DJ.<a href="https://pubmed.ncbi.nlm.nih.gov/25390741/"> The α-thalassemias.</a> N Engl J Med. 2014 Nov 13;371(20):1908-16. doi: 10.1056/NEJMra1404415. PMID: 25390741.</div> </li> <li> <div class="citation-text">Yawn BP, Buchanan GR, Afenyi-Annan AN, Ballas SK, Hassell KL, James AH, Jordan L, Lanzkron SM, Lottenberg R, Savage WJ, Tanabe PJ, Ware RE, Murad MH, Goldsmith JC, Ortiz E, Fulwood R, Horton A, John-Sowah J. <a href="https://pubmed.ncbi.nlm.nih.gov/25203083/">Management of sickle cell disease: summary of the 2014 evidence-based report by expert panel members.</a> JAMA. 2014 Sep 10;312(10):1033-48. doi: 10.1001/jama.2014.10517. Erratum in: JAMA. 2014 Nov 12;312(18):1932. Erratum in: JAMA. 2015 Feb 17;313(7):729. PMID: 25203083.</div> </li> <li> <div class="citation-text">Ohlsson A, Aher SM. <a href="https://pubmed.ncbi.nlm.nih.gov/16856062/">Early erythropoietin for preventing red blood cell transfusion in preterm and/or low birth weight infants.</a> Cochrane Database Syst Rev. 2006 Jul 19;(3):CD004863. doi: 10.1002/14651858.CD004863.pub2. Update in: Cochrane Database Syst Rev. 2012 Sep 12;(9):CD004863. doi: 10.1002/14651858.CD004863.pub3. PMID: 16856062.</div> </li> <li> <div class="citation-text">El Raziky MS, Ali A, El Shahawy A, Hamdy MM. <a href="https://pubmed.ncbi.nlm.nih.gov/24577547/">Acute hemolytic anemia as an initial presentation of Wilson disease in children.</a> J Pediatr Hematol Oncol. 2014 Apr;36(3):173-8. doi: 10.1097/MPH.0000000000000127. PMID: 24577547.</div> </li> <li> <div class="citation-text">Vagace JM, Bajo R, Gervasini G. <a href="https://pubmed.ncbi.nlm.nih.gov/24599068/">Diagnostic and therapeutic challenges of primary autoimmune haemolytic anaemia in children.</a> Arch Dis Child. 2014 Jul;99(7):668-73. doi: 10.1136/archdischild-2013-305748. Epub 2014 Mar 5. PMID: 24599068.</div> <div class="citation-actions"></div> </li> </ol> <p></div></div> <div style="background: #f7f7f7;border: 1px solid rgba(0, 0, 0, 0.07);"> <div style="padding: 30px;"><div class="Adblock-main"> <div class="Adblock-head"> <h2>Top Experts on “<b style="color:#000;font-size:22px;">pediatric anemia</b>“</h2> </div> </div><div class="author-main"><div id="results_author"></div><div style="text-align: center;"><a class="register-button" href="https://neonataldisorders.com/expert-search" target="_blank" rel="noopener">Find experts on any field</a></div></div><div class="inside-article" style="background: none;border: none;box-shadow: none;margin-top: -70px;"> <style> .author-block { padding: 15px; margin-bottom: 10px; text-align: left; font-size: 15px; line-height: 1.2; background: #FFF; border-bottom: solid 1px #ccc; margin-left: 15px; margin-right: 15px; } .author-block h3 { margin: 0 0 10px; color: #227cdc; } .author-block p { margin: 5px 0; } .author-b { display: flex; justify-content: space-between; flex-wrap: wrap; margin-bottom:10px; } .author-b .ainfo { flex: 1 1 30%; box-sizing: border-box; text-align: left; background: #dcdcdc; padding: 7px 14px; border-radius: 5px; margin-top: 3px; margin-right: 10px; } @media (max-width: 768px) { .author-b .ainfo { flex: 1 1 100%; margin: 10px 0; } } </style> <script> function displayResults_author(authors) { var resultsContainer = document.getElementById('results_author'); resultsContainer.innerHTML = ''; if (!authors || Object.keys(authors).length === 0) { resultsContainer.innerHTML = '<p>No authors found.</p>'; return; } Object.values(authors).slice(0, 10).forEach(author => { if (author.affiliation.length > 400) { return; } var authorBlock = document.createElement('div'); authorBlock.className = 'author-block'; var author_name=author.name; let key_replace = author_name.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); var authorHTML = ` <h3><a href="https://neonataldisorders.com/author/index/${key_replace}\/${author.aid}" target="_blank" title="${author.name}">${author.name}</a></h3> <div class="author-b"> <div class="ainfo"><strong>H-Index:</strong> ${author.hindex}</div> <div class="ainfo"><strong>Publication Count:</strong> ${author.paper_count}</div> <div class="ainfo"><strong>Citation Count:</strong> ${author.citation_count}</div> </div> <p><strong>Affiliation:</strong> ${author.affiliation}</p> `; authorBlock.innerHTML = authorHTML; resultsContainer.appendChild(authorBlock); }); } function displayKeywordAuthors(keywords) { var resultsContainer = document.getElementById('keyword-authors'); resultsContainer.innerHTML = ''; if (!keywords || keywords.length === 0) { resultsContainer.innerHTML = '<p>No data found.</p>'; return; } var keywordHTML = ''; keywords.forEach(key => { let key_replace = key.replace(/ /g, '-'); key_replace = key_replace.toLowerCase(); keywordHTML += `<a href="https://neonataldisorders.com/expert-search/index/${key_replace}" target="_blank" title="${key}">${key}</a>`; }); resultsContainer.innerHTML = keywordHTML; } // Call the function with the PHP data var authors_data = { "LEvgKowBWBy50K-rh7lJ": { "aid": "LEvgKowBWBy50K-rh7lJ", "name": "Haley L. Cash", "citation_count": 421, "hindex": 11, "paper_count": 44, "affiliation": "Pacific Island Health Officers Association, Honolulu, Hawaii, USA ", "email": "haleyc@pihoa.org", "slug_tail": "haley-l-cash" }, "vRNuK4wBWBy50K-rIU7i": { "aid": "vRNuK4wBWBy50K-rIU7i", "name": "Shannon M. Fuller", "citation_count": 165, "hindex": 8, "paper_count": 26, "affiliation": "Division of Prevention Science, University of California San Francisco, 550 16th St., 3rd Floor, UCSF Mailcode 0886, San Francisco, CA, 94143, USA. ", "email": "shannon.fuller@ucsf.edu", "slug_tail": "shannon-m-fuller" }, "MDDbKowBWBy50K-rx4IM": { "aid": "MDDbKowBWBy50K-rx4IM", "name": "D. K. Koum", "citation_count": 38, "hindex": 3, "paper_count": 14, "affiliation": "Faculty of Medicine and Pharmaceutical Sciences, The University of Douala, P.O Box: 8037, Douala, Cameroon. 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