PDB-101: Learn: Structural Biology Highlights: Introduction

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.fa-cloud-download { margin-left:10px; } /* customize div.img-with-caption in style.css */ div.img-with-caption { max-width: 75%; } </style> <div class="pdb101-page-content"> <div data-elastic-include> <h1>Introduction</h1> <p>Each structure in the Protein Data Bank contributes to our greater understanding of biology and medicine.</p> <p>These Structural Biology Highlights explore some of the structures made possible by the Protein Structure Initiative (PSI) supported by the NIGMS from 2000-2015.</p> <p>PSI researchers focused on accelerating discovery in structural genomics and contributing to understanding biological function. As a result, PSI efforts developed new technologies and methods that improved the process of protein structure determination and prediction.</p> <p>Over its 15-year period, nearly 7000 PDB structures were determined. <a href='/learn/structural-biology-highlights/index'>Many of these structural advances are highlighted in these Structural Biology Highlight articles (formerly called Featured Systems)</a>.</p> <div class="img-with-caption"> <div class="img-with-caption-table"><a href="/learn/structural-biology-highlights/g-protein-coupled-receptors"><img src="https://cdn.rcsb.org/pdb101/learn/images/gpcr-tree-structures13-1200px.png" class="img-responsive"></a> <div class="img-caption"> <div style="margin-bottom:10px;"><i>PSI researchers explored the functional diversity of GPCR structures. For more information, see the highlight on <a href='/learn/structural-biology-highlights/g-protein-coupled-receptors'>G-Protein Coupled Receptors</a>.</i></div><a href="https://cdn.rcsb.org/pdb101/learn/images/gpcr-tree-structures13.tif">Download high quality TIFF image<span class="fa fa-cloud-download"></span></a> </div> </div> </div> <h5>References</h5> <p>These articles, written by Molecule of the Month creator David S. Goodsell, originally appeared at the Structural Biology Knowledgebase website (<a href='http://sbkb.org' target='_blank'>SBKB.org</a>) that served as an information portal for PSI structures, theoretical models, technologies, and related information.</p> <p>The Structural Biology Knowledgebase: a portal to protein structures, sequences, functions, and methods. M. J. Gabanyi, P. D. Adams, K. Arnold, L. Bordoli, L. G. Carter, J. Flippen-Andersen, L. Gifford, J. Haas, A. Kouranov, W. A. McLaughlin, D. I. Micallef, W. Minor, R. Shah, T. Schwede, Y. P. Tao, J. D. Westbrook, M. Zimmerman, H. M. Berman. (2011) <i>J Struct Funct Genomics</i> 12: 45-54. <a href='http://dx.doi.org/10.1007/s10969-011-9106-2' target='_blank'>doi: 10.1007/s10969-011-9106-2</a></p> </div> </div> </div> <div id="footer_main" class="hidden-print"> <div class="container"> <div class="row"> <div class="col-sm-12 col-md-7"> <p><strong>About PDB-101</strong></p> <p>Researchers around the globe make 3D structures freely available from the Protein Data Bank (PDB) archive. PDB-101 training materials help graduate students, postdoctoral scholars, and researchers use PDB data and RCSB PDB tools. Outreach content demonstrate how PDB data impact fundamental biology, biomedicine, bioengineering/biotechnology, and energy sciences in 3D for a diverse and multidisciplinary user community. Education Materials provide lessons and activities for teaching and learning.</p> <p>PDB-101 is developed by the <a href="https://rcsb.org" target="_blank">RCSB PDB</a>.</p> </div> <div class="col-sm-12 col-md-5 text-center"> <p>RCSB PDB (<a href="http://nar.oxfordjournals.org/content/28/1/235.abstract" target="blank">citation</a>) is hosted by</p><img src="//cdn.rcsb.org/pdb101/common/images/Logo_Rutgers-2024.png" alt="Rutgers University logo" usemap="#rutgers-map" height="32" style="padding:0px 10px; border-right: 1px solid #000000;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSD-SDSC.png" alt="University of California San Diego/San Diego Supercomputer Center logos" usemap="#UCSD-SDSC-map" height="26" style="padding: 0px 10px; border-right: 1px solid #000000;"><img src="//cdn.rcsb.org/pdb101/common/images/Logo_UCSF.png" alt="Univesity of California San Franciscologo" usemap="#UCSF-map" height="26" style="padding-left: 10px;"><map name="rutgers-map"> <area shape="rect" coords="0,0,115,26" href="http://www.rutgers.edu/" alt="Rutgers" target="_blank"></map><map name="UCSD-SDSC-map"> <area shape="rect" coords="0,0,150,26" href="http://ucsd.edu/" alt="UCSD" target="_blank"> <area shape="rect" coords="151,0,255,26" href="http://www.sdsc.edu/" alt="SDSC" target="_blank"></map><map name="UCSF-map"> <area shape="rect" coords="0,0,64,26" href="http://www.ucsf.edu/" alt="UCSF" target="_blank"></map><br><br> <p>RCSB PDB is a member of <span id='pdbmembers_footer'><a href='http://www.wwpdb.org/' target='_blank'><img src='//cdn.rcsb.org/pdb101/common/images/Logo_wwpdb.png' width='70'></a><span class='pipe'></span><a href='http://www.emdatabank.org/' target='_blank'><img src='https://cdn.rcsb.org/pdb101/common/images/EMDataResourcelogo.png' width='100'></a></p> </div> </div> </div> </div> <div id="footer_grant" class="hidden-print"> <div class="container"> <div class="row"> <p>RCSB PDB Core Operations are funded by the <a href="http://www.nsf.gov/" target="_blank">U.S. National Science Foundation</a> (DBI-2321666), the <a href="http://science.energy.gov/" target="_blank">US Department of Energy</a> (DE-SC0019749), and the <a href="http://www.cancer.gov/" target="_blank">National Cancer Institute</a>, <a href="http://www.niaid.nih.gov/" target="_blank">National Institute of Allergy and Infectious Diseases</a>, and <a href="http://www.nigms.nih.gov/" target="_blank">National Institute of General Medical Sciences</a> of the <a href="http://www.nih.gov/" target="_blank">National Institutes of Health</a> under grant R01GM157729.</p> </div> </div> </div> <div id="jira-fdbck"></div><script> //Google Analytics tracking code {/* (function(i,s,o,g,r,a,m){i['GoogleAnalyticsObject']=r;i[r]=i[r]||function(){ (i[r].q=i[r].q||[]).push(arguments)},i[r].l=1*new Date();a=s.createElement(o), m=s.getElementsByTagName(o)[0];a.async=1;a.src=g;m.parentNode.insertBefore(a,m) })(window,document,'script','//www.google-analytics.com/analytics.js','ga'); ga('create', 'UA-71059016-1', 'auto'); ga('send', 'pageview'); */} </script> </div> </body> </html>

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PDB-101: Learn: Structural Biology Highlights: Introduction