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(PDF) Parasporins as a natural anti-cancer protein | Hatice Gunes - Academia.edu

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Sporulasyon evresinde, sporlarla birlikte birçok böcek çeşidine karşı insektisit etki gösteren kristal proteinleri de üretir. İnsektisidal kristal proteinler Cry ve Cyt proteinler olup; aktivitelerini duyarlı böceklerin orta barsak membranlarında bulunan reseptöre bağlanarak gösterirler. Bu reseptör bağlantılı özgül aktivitelerinden dolayı zirai mücadelede önemlidirler. Daha sonraları, insektisit olanlara göre doğada daha geniş dağılım gösteren insektisit olmayan kristal proteinler üzerindeki çalışmalar yeni bir protein sınıfı olan parasporinleri ortaya çıkarmıştır. Parasporinler ayrıcalıklı olarak kanser hücrelerine karşı sitotoksik etki gösterirken normal hücrelere etki etmez ve hemolitik etki göstermez. Şimdiye kadar altı parasporin ailesi tanımlanmış olup toplamda 19 alt grup bilinmektedir. Parasporinler de insektisidal kristal proteinlere benzer şekilde reseptör bağlantılı etki gösterdiğinden kanser tedavisiyle ilgili çalışmalarda yeni bir araştırma alanının ortaya çıkmasını sağlamıştır. Bu derlemede; parasporinlerin keşfi, özellikleri, çeşitleri ve etki mekanizmaları hakkında yapılmış olan çalışmalar özetle anlatılmıştır.","publication_date":"2017,,","publication_name":"ANADOLU UNIVERSITY JOURNAL OF SCIENCE AND TECHNOLOGY –C Life Sciences and Biotechnology","grobid_abstract_attachment_id":"99969902"},"document_type":"paper","pre_hit_view_count_baseline":null,"quality":"high","language":"tr","title":"Parasporins as a natural anti-cancer protein","broadcastable":true,"draft":null,"has_indexable_attachment":true,"indexable":true}}["work"]; window.loswp.workCoauthors = [262028830]; window.loswp.locale = "en"; window.loswp.countryCode = "SG"; window.loswp.cwvAbTestBucket = ""; window.loswp.designVariant = "ds_vanilla"; window.loswp.fullPageMobileSutdModalVariant = "control"; window.loswp.useOptimizedScribd4genScript = false; window.loswp.appleClientId = 'edu.academia.applesignon';</script><script defer="" src="https://accounts.google.com/gsi/client"></script><div 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Hücre ölümünün temel olarak apoptozis (programlı hücre ölümü) ve nekrozis olmak üzere 2 tür olduğu düşünülüyordu fakat son yıllarda bir hücrenin çok daha farklı yollarla ölebileceğini gösteren hücre ölüm türleri tanımlanmıştır. Bu hücre ölüm tiplerinden yeni keşfedilen piroptozis, inflamatuvar ve immün sistem tepkisi ile birlikte gasdermin ailesinin aracılık ettiği bir süreçten meydana gelmektedir. Piroptozisin kanser üzerindeki etkileri karmaşıktır ve genetik yapı ile değişiklik gösterebilir. Bir yandan piroptozis tümör oluşumunu ve gelişmesini inhibe ederken diğer yandan tömür oluşumu için uygun mikroçevreyi destekleyebilir. Ayrıca tümör hücrelerinde piroptozisin manipülasyonlarının kanser tedavisine alternatif sağlayabileceği düşünülmektedir. 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