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href="https://cpmtc-igc-ufmg.academia.edu/">Univerdade Federal de Minas Gerais</a>, <a class="u-tcGrayDarker" href="https://cpmtc-igc-ufmg.academia.edu/Departments/Departamento_de_Biologia_Geral/Documents">Departamento de Biologia Geral</a>, <span class="u-tcGrayDarker">Faculty Member</span></div></div></div></div><div class="sidebar-cta-container"><button class="ds2-5-button hidden profile-cta-button grow js-profile-follow-button" data-broccoli-component="user-info.follow-button" data-click-track="profile-user-info-follow-button" data-follow-user-fname="Romeu" data-follow-user-id="18191518" data-follow-user-source="profile_button" data-has-google="false"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">add</span>Follow</button><button class="ds2-5-button hidden profile-cta-button grow js-profile-unfollow-button" data-broccoli-component="user-info.unfollow-button" data-click-track="profile-user-info-unfollow-button" data-unfollow-user-id="18191518"><span class="material-symbols-outlined" style="font-size: 20px" translate="no">done</span>Following</button></div></div><div class="user-stats-container"><a><div class="stat-container js-profile-followers"><p class="label">Followers</p><p class="data">45</p></div></a><a><div class="stat-container js-profile-followees" data-broccoli-component="user-info.followees-count" data-click-track="profile-expand-user-info-following"><p class="label">Following</p><p class="data">12</p></div></a><a><div class="stat-container js-profile-coauthors" data-broccoli-component="user-info.coauthors-count" data-click-track="profile-expand-user-info-coauthors"><p class="label">Co-authors</p><p class="data">7</p></div></a><a href="/RomeuGuimaraes/mentions"><div class="stat-container"><p class="label">Mentions</p><p class="data">1</p></div></a><span><div class="stat-container"><p class="label"><span class="js-profile-total-view-text">Public Views</span></p><p class="data"><span class="js-profile-view-count"></span></p></div></span></div><div class="user-bio-container"><div class="profile-bio fake-truncate js-profile-about" style="margin: 0px;"><span class="u-fw700">Phone: </span>+55-31-988976439<br /><b>Address: </b>Av Assis Chateaubriand 414 Apt 1002 Belo Horizonte 30150-101 MG Brasil TelFax +55-31-32744988<br /><div class="js-profile-less-about u-linkUnstyled u-tcGrayDarker u-textDecorationUnderline u-displayNone">less</div></div></div><div class="ri-section"><div class="ri-section-header"><span>Interests</span></div><div class="ri-tags-container"><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="18191518" href="https://www.academia.edu/Documents/in/Genetic_Code"><div id="js-react-on-rails-context" style="display:none" 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data-dom-id="Pill-react-component-b76797a9-b3b8-44a5-9e42-2d16ea770b67"></div> <div id="Pill-react-component-b76797a9-b3b8-44a5-9e42-2d16ea770b67"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="18191518" href="https://www.academia.edu/Documents/in/Philosophy_of_Science"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Philosophy of Science"]}" data-trace="false" data-dom-id="Pill-react-component-ef005624-2137-4199-83f6-bf480be3a2e4"></div> <div id="Pill-react-component-ef005624-2137-4199-83f6-bf480be3a2e4"></div> </a><a data-click-track="profile-user-info-expand-research-interests" data-has-card-for-ri-list="18191518" href="https://www.academia.edu/Documents/in/Evolution"><div class="js-react-on-rails-component" style="display:none" data-component-name="Pill" data-props="{"color":"gray","children":["Evolution"]}" data-trace="false" data-dom-id="Pill-react-component-1b5614eb-4508-41ee-9911-7d163eeb00d5"></div> <div id="Pill-react-component-1b5614eb-4508-41ee-9911-7d163eeb00d5"></div> </a></div></div><div class="external-links-container"><ul class="profile-links new-profile js-UserInfo-social"><li class="profile-profiles js-social-profiles-container"><i class="fa fa-spin fa-spinner"></i></li></ul></div></div></div><div class="right-panel-container"><div class="user-content-wrapper"><div class="uploads-container" id="social-redesign-work-container"><div class="upload-header"><h2 class="ds2-5-heading-sans-serif-xs">Uploads</h2></div><div class="nav-container backbone-profile-documents-nav hidden-xs"><ul class="nav-tablist" role="tablist"><li class="nav-chip active" role="presentation"><a data-section-name="" data-toggle="tab" href="#all" role="tab">all</a></li><li class="nav-chip" role="presentation"><a class="js-profile-docs-nav-section u-textTruncate" data-click-track="profile-works-tab" data-section-name="Papers" data-toggle="tab" href="#papers" role="tab" title="Papers"><span>140</span> <span class="ds2-5-body-sm-bold">Papers</span></a></li><li class="nav-chip" role="presentation"><a class="js-profile-docs-nav-section u-textTruncate" data-click-track="profile-works-tab" data-section-name="Conference-Presentations" data-toggle="tab" href="#conferencepresentations" role="tab" title="Conference Presentations"><span>1</span> <span class="ds2-5-body-sm-bold">Conference Presentations</span></a></li></ul></div><div class="divider ds-divider-16" style="margin: 0px;"></div><div class="documents-container backbone-social-profile-documents" style="width: 100%;"><div class="u-taCenter"></div><div class="profile--tab_content_container js-tab-pane tab-pane active" id="all"><div class="profile--tab_heading_container js-section-heading" data-section="Papers" id="Papers"><h3 class="profile--tab_heading_container">Papers by Romeu C Guimaraes</h3></div><div class="js-work-strip profile--work_container" 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src="https://attachments.academia-assets.com/109142122/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674919/VIDA_IDENTIDAD_E_INFORMACI%C3%93N_Life_Identity_and_Information">VIDA, IDENTIDAD E INFORMACIÓN Life, Identity & Information</a></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Resumen La sustitución experimental de genomas significa la creación de especies nuevas o la repr...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Resumen La sustitución experimental de genomas significa la creación de especies nuevas o la reprogramación genética de seres vivos, pero no la creación de vida. El proceso de integración del nuevo genoma al sistema metabólico receptor implica la sustitución gradual de las macromoléculas y no implica la existencia de la entidad especial llamada de información con respecto a la organización sistémica. 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The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674918"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674918"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674918; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674918]").text(description); $(".js-view-count[data-work-id=111674918]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674918; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674918']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674918, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674918]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674918,"title":"Uptake of purine bases by Trypanosoma cruzi culture epimastigotes","translated_title":"","metadata":{"abstract":"The uptake of adenine, guanine and hypoxanthine by Trypanosoma cruzi culture epimastigotes was studied over short time periods at 22 degrees C. The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.","publication_date":{"day":null,"month":null,"year":1986,"errors":{}},"publication_name":"PubMed"},"translated_abstract":"The uptake of adenine, guanine and hypoxanthine by Trypanosoma cruzi culture epimastigotes was studied over short time periods at 22 degrees C. The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.","internal_url":"https://www.academia.edu/111674918/Uptake_of_purine_bases_by_Trypanosoma_cruzi_culture_epimastigotes","translated_internal_url":"","created_at":"2023-12-17T16:36:21.635-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Uptake_of_purine_bases_by_Trypanosoma_cruzi_culture_epimastigotes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The uptake of adenine, guanine and hypoxanthine by Trypanosoma cruzi culture epimastigotes was studied over short time periods at 22 degrees C. The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.","owner":{"id":18191518,"first_name":"Romeu","middle_initials":"C","last_name":"Guimaraes","page_name":"RomeuGuimaraes","domain_name":"cpmtc-igc-ufmg","created_at":"2014-10-08T00:13:53.882-07:00","display_name":"Romeu C Guimaraes","url":"https://cpmtc-igc-ufmg.academia.edu/RomeuGuimaraes"},"attachments":[],"research_interests":[{"id":145,"name":"Biochemistry","url":"https://www.academia.edu/Documents/in/Biochemistry"},{"id":523,"name":"Chemistry","url":"https://www.academia.edu/Documents/in/Chemistry"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":98939,"name":"Pubmed","url":"https://www.academia.edu/Documents/in/Pubmed"},{"id":305763,"name":"Purine","url":"https://www.academia.edu/Documents/in/Purine"},{"id":376084,"name":"Trypanosoma Cruzi","url":"https://www.academia.edu/Documents/in/Trypanosoma_Cruzi"},{"id":957359,"name":"Culture Media","url":"https://www.academia.edu/Documents/in/Culture_Media"},{"id":1169265,"name":"Adenine","url":"https://www.academia.edu/Documents/in/Adenine"},{"id":1451232,"name":"Nucleotide","url":"https://www.academia.edu/Documents/in/Nucleotide"},{"id":3663865,"name":"purines","url":"https://www.academia.edu/Documents/in/purines"},{"id":3763225,"name":"Medical and Health Sciences","url":"https://www.academia.edu/Documents/in/Medical_and_Health_Sciences"}],"urls":[{"id":37277905,"url":"https://pubmed.ncbi.nlm.nih.gov/3297217"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674915/Towards_functional_repertoire_of_the_earliest_proteins"><img alt="Research paper thumbnail of Towards functional repertoire of the earliest proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674915/Towards_functional_repertoire_of_the_earliest_proteins">Towards functional repertoire of the earliest proteins</a></div><div class="wp-workCard_item"><span>Journal of Biomolecular Structure & Dynamics</span><span>, Nov 1, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent motifs,&amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six &amp;quot;omnipresent&amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β&amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674915; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674915]").text(description); $(".js-view-count[data-work-id=111674915]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674915; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674915']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674915, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674915]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674915,"title":"Towards functional repertoire of the earliest proteins","translated_title":"","metadata":{"abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). 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Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. 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No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. 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AGR,DEPT GENET,BOTUCATU,BRAZIL","owner":{"id":18191518,"first_name":"Romeu","middle_initials":"C","last_name":"Guimaraes","page_name":"RomeuGuimaraes","domain_name":"cpmtc-igc-ufmg","created_at":"2014-10-08T00:13:53.882-07:00","display_name":"Romeu C Guimaraes","url":"https://cpmtc-igc-ufmg.academia.edu/RomeuGuimaraes"},"attachments":[],"research_interests":[{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":1727314,"name":"Nucleic Acid","url":"https://www.academia.edu/Documents/in/Nucleic_Acid"}],"urls":[{"id":37277901,"url":"http://repositorio.unesp.br/handle/11449/37619"}]}, dispatcherData: dispatcherData }); $(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674913"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674913/Biodiversidade_e_Religi%C3%A3o"><img alt="Research paper thumbnail of Biodiversidade e Religião" class="work-thumbnail" src="https://attachments.academia-assets.com/109142118/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674913/Biodiversidade_e_Religi%C3%A3o">Biodiversidade e Religião</a></div><div class="wp-workCard_item"><span>Horizonte: revista de Estudos de Teologia e Ciências da Religiao</span><span>, 2010</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Biodiversidade e Religião Biodiversity and religion Resumo Neste trabalho, explora-se o conceito ...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Biodiversidade e Religião Biodiversity and religion Resumo Neste trabalho, explora-se o conceito de que a diversidade propicia robustez nos sistemas processadores de informação, o que seria aplicável às areas neurais e so fenômeno religioso. Discutem sob a proposta de que demarcação adequada pode auxiliar na redução de conflitos. Nesse mesmo sentido pode contribuir a elaboração sobre as tensõ determinismos-e liberdades, que decorreriam do uso dos conceitos de crenças fortes e fracas, ou seja, entre crenças e hipóteses que parecem promissoras, merecedoras de créditos de confiança. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674909"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111674909/Trypanosoma_Cruzi_Rna_Characterization_in_CL_Strain"><img alt="Research paper thumbnail of Trypanosoma-Cruzi Rna - Characterization in CL Strain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111674909/Trypanosoma_Cruzi_Rna_Characterization_in_CL_Strain">Trypanosoma-Cruzi Rna - Characterization in CL Strain</a></div><div class="wp-workCard_item"><span>European Journal of Cell Biology</span><span>, 1980</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674909"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674909"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674909; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674908"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors"><img alt="Research paper thumbnail of Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors">Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors</a></div><div class="wp-workCard_item"><span>Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predict...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. The alterations caused by urate are complex, apparently involving inhibition of the monooxypurine phosphoribosyltransferase and induction of permeation of purines into the cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674908"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674908"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674908; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674908]").text(description); $(".js-view-count[data-work-id=111674908]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674908; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674908']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674908, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674908]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674908,"title":"Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors","translated_title":"","metadata":{"abstract":"1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. 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All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. The alterations caused by urate are complex, apparently involving inhibition of the monooxypurine phosphoribosyltransferase and induction of permeation of purines into the cells.","internal_url":"https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors","translated_internal_url":"","created_at":"2023-12-17T16:36:19.186-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674903"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins"><img alt="Research paper thumbnail of Towards functional repertoire of the earliest proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins">Towards functional repertoire of the earliest proteins</a></div><div class="wp-workCard_item"><span>Journal of Biomolecular Structure and Dynamics</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent motifs,&amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six &amp;quot;omnipresent&amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β&amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674903"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674903"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674903; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674903]").text(description); $(".js-view-count[data-work-id=111674903]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674903; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674903']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674903, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674903]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674903,"title":"Towards functional repertoire of the earliest proteins","translated_title":"","metadata":{"abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Biomolecular Structure and Dynamics"},"translated_abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","internal_url":"https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins","translated_internal_url":"","created_at":"2023-12-17T16:36:18.532-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Towards_functional_repertoire_of_the_earliest_proteins","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","owner":{"id":18191518,"first_name":"Romeu","middle_initials":"C","last_name":"Guimaraes","page_name":"RomeuGuimaraes","domain_name":"cpmtc-igc-ufmg","created_at":"2014-10-08T00:13:53.882-07:00","display_name":"Romeu C Guimaraes","url":"https://cpmtc-igc-ufmg.academia.edu/RomeuGuimaraes"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":3701,"name":"RNA","url":"https://www.academia.edu/Documents/in/RNA"},{"id":4233,"name":"Computational Biology","url":"https://www.academia.edu/Documents/in/Computational_Biology"},{"id":4967,"name":"Molecular Evolution","url":"https://www.academia.edu/Documents/in/Molecular_Evolution"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":857512,"name":"Proteases","url":"https://www.academia.edu/Documents/in/Proteases"},{"id":1035050,"name":"Proteome","url":"https://www.academia.edu/Documents/in/Proteome"},{"id":1588981,"name":"Protein Biosynthesis","url":"https://www.academia.edu/Documents/in/Protein_Biosynthesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":3585436,"name":"conserved sequence ","url":"https://www.academia.edu/Documents/in/conserved_sequence"}],"urls":[{"id":37277896,"url":"http://www.tandfonline.com/doi/pdf/10.1080/10256018808623883"}]}, dispatcherData: dispatcherData }); 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Statistical surveys have shown an increase in the production of alcoholic beverages of all kinds, and also provide evidence for the per capita alcohol consumption [1]. Such increment in the abusive ingestion of alcohol as severe individual, social and economic consequences, which motivates a growing number of investigations. The World Health Organization (WHO) classifies as aged, in developing countries, individuals higher than 60 years of age. The fraction of aged in the Brazilian population has grown from 4.8% in 1991 to 5.8% in 2000 and 7.4% in 2010 [2]. It is known that there are differences in the patterns of alcoholism according to the age segments, especially between the aged and non-aged groups [3]. 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The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674918"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674918"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674918; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674918]").text(description); $(".js-view-count[data-work-id=111674918]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674918; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674918']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674918, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674918]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674918,"title":"Uptake of purine bases by Trypanosoma cruzi culture epimastigotes","translated_title":"","metadata":{"abstract":"The uptake of adenine, guanine and hypoxanthine by Trypanosoma cruzi culture epimastigotes was studied over short time periods at 22 degrees C. The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. 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When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. This depression may be a cause of the mitotic blockade which occurs during the stationary phase.","internal_url":"https://www.academia.edu/111674918/Uptake_of_purine_bases_by_Trypanosoma_cruzi_culture_epimastigotes","translated_internal_url":"","created_at":"2023-12-17T16:36:21.635-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Uptake_of_purine_bases_by_Trypanosoma_cruzi_culture_epimastigotes","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The uptake of adenine, guanine and hypoxanthine by Trypanosoma cruzi culture epimastigotes was studied over short time periods at 22 degrees C. The uptake process is concentrative, driven by the purine phosphoribosyltransferases and saturable at about 10 microM hypoxanthine and 1 microM adenine or guanine. Each purine base is apparently taken up by a separate route and the oxypurines are regulated in parallel. Adenine inhibits oxypurine uptake. When the material was incubated with guanine or hypoxanthine for more than 2 min, a decrease in the nucleotide/free base ratio was observed, indicating inhibition of the guanine and hypoxanthine phosphoribosyltransferases. The uptake rates during the ascending phase of uptake and of culture growth rates were of the order of 50 for hypoxanthine and 20 for guanine, relative to that of adenine. These rates were within the physiological range for cell growth in these cultures. During the phase of descending growth and decreased purine uptake activity rates, uptake was depressed to 20% of the rates required for the growth observed in the cultures. It is proposed that the decline in growth rate leads to an increase of the nucleotide pools in the cells which inhibit uptake. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674917"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111674917/Evolution_of_Adenine_Clustering_in_5S_Ribosomal_Rna"><img alt="Research paper thumbnail of Evolution of Adenine Clustering in 5S Ribosomal-Rna" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111674917/Evolution_of_Adenine_Clustering_in_5S_Ribosomal_Rna">Evolution of Adenine Clustering in 5S Ribosomal-Rna</a></div><div class="wp-workCard_item"><span>Endocytobiosis and Cell Research</span><span>, Dec 1, 1992</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674917"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674917"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674917; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674916"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" rel="nofollow" href="https://www.academia.edu/111674916/Trypanosoma_cruzi_host_cell_interactions_and_the_temperature_sensitive_phenotype_of_CL_strain"><img alt="Research paper thumbnail of Trypanosoma cruzi - host cell interactions and the temperature-sensitive phenotype of CL strain" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" rel="nofollow" href="https://www.academia.edu/111674916/Trypanosoma_cruzi_host_cell_interactions_and_the_temperature_sensitive_phenotype_of_CL_strain">Trypanosoma cruzi - host cell interactions and the temperature-sensitive phenotype of CL strain</a></div><div class="wp-workCard_item"><span>Ciencia e Cultura</span><span>, 1980</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">ABSTRACT</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674916"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674916"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674916; 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674915"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674915/Towards_functional_repertoire_of_the_earliest_proteins"><img alt="Research paper thumbnail of Towards functional repertoire of the earliest proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674915/Towards_functional_repertoire_of_the_earliest_proteins">Towards functional repertoire of the earliest proteins</a></div><div class="wp-workCard_item"><span>Journal of Biomolecular Structure & Dynamics</span><span>, Nov 1, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent motifs,&amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six &amp;quot;omnipresent&amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β&amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674915"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674915"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674915; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674915]").text(description); $(".js-view-count[data-work-id=111674915]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674915; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674915']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674915, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674915]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674915,"title":"Towards functional repertoire of the earliest proteins","translated_title":"","metadata":{"abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","publisher":"Taylor \u0026 Francis","publication_date":{"day":1,"month":11,"year":2013,"errors":{}},"publication_name":"Journal of Biomolecular Structure \u0026 Dynamics"},"translated_abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","internal_url":"https://www.academia.edu/111674915/Towards_functional_repertoire_of_the_earliest_proteins","translated_internal_url":"","created_at":"2023-12-17T16:36:20.901-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Towards_functional_repertoire_of_the_earliest_proteins","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. 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AGR,DEPT GENET,BOTUCATU...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">UNIV ESTADUAL PAULISTA JULIO DE MESQUITA FILHO,INST BASICO BIOL MED &amp; AGR,DEPT GENET,BOTUCATU,BRAZIL</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674914"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674914"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674914; 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Discutem sob a proposta de que demarcação adequada pode auxiliar na redução de conflitos. Nesse mesmo sentido pode contribuir a elaboração sobre as tensõ determinismos-e liberdades, que decorreriam do uso dos conceitos de crenças fortes e fracas, ou seja, entre crenças e hipóteses que parecem promissoras, merecedoras de créditos de confiança. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674908"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors"><img alt="Research paper thumbnail of Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors">Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors</a></div><div class="wp-workCard_item"><span>Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]</span><span>, 1987</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predict...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. The alterations caused by urate are complex, apparently involving inhibition of the monooxypurine phosphoribosyltransferase and induction of permeation of purines into the cells.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674908"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674908"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674908; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674908]").text(description); $(".js-view-count[data-work-id=111674908]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674908; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674908']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674908, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674908]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674908,"title":"Purine base uptake in Trypanosoma cruzi: adaptations and effects of inhibitors","translated_title":"","metadata":{"abstract":"1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. 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All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. The alterations caused by urate are complex, apparently involving inhibition of the monooxypurine phosphoribosyltransferase and induction of permeation of purines into the cells.","internal_url":"https://www.academia.edu/111674908/Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors","translated_internal_url":"","created_at":"2023-12-17T16:36:19.186-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Purine_base_uptake_in_Trypanosoma_cruzi_adaptations_and_effects_of_inhibitors","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"1. The pattern of purine base uptake in culture epimastigotes of Trypanosoma cruzi can be predicted from cell growth rate and cell concentration, with the late log phase showing the greatest variability. 2. Uptake rates are unexpectedly low in the reproductive tissue amastigotes and high in the non-reproductive blood trypomastigotes. It is suggested that blood trypomastigotes metabolize and accumulate reserves of purine metabolites, whereas amastigotes depend on degradation of host cell RNA and nucleotides as purine sources. 3. All parasite forms salvage hypoxanthine and guanine in preference to adenine. Nifurtimox, dipyridamole and cytochalasin have no effect on uptake, whereas amphotericin B, allopurinol, xanthine and urate inhibit it. 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674903"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins"><img alt="Research paper thumbnail of Towards functional repertoire of the earliest proteins" class="work-thumbnail" src="https://a.academia-assets.com/images/blank-paper.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins">Towards functional repertoire of the earliest proteins</a></div><div class="wp-workCard_item"><span>Journal of Biomolecular Structure and Dynamics</span><span>, 2013</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">The conserved protein sequence motifs present in all prokaryotic proteomes, &amp;quot;omnipresent motifs,&amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six &amp;quot;omnipresent&amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β&amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="111674903"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="111674903"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 111674903; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=111674903]").text(description); $(".js-view-count[data-work-id=111674903]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 111674903; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='111674903']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 111674903, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (false){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "-1" } } $('.js-work-strip[data-work-id=111674903]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":111674903,"title":"Towards functional repertoire of the earliest proteins","translated_title":"","metadata":{"abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","publisher":"Informa UK Limited","publication_date":{"day":null,"month":null,"year":2013,"errors":{}},"publication_name":"Journal of Biomolecular Structure and Dynamics"},"translated_abstract":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","internal_url":"https://www.academia.edu/111674903/Towards_functional_repertoire_of_the_earliest_proteins","translated_internal_url":"","created_at":"2023-12-17T16:36:18.532-08:00","preview_url":null,"current_user_can_edit":null,"current_user_is_owner":null,"owner_id":18191518,"coauthors_can_edit":true,"document_type":"paper","co_author_tags":[],"downloadable_attachments":[],"slug":"Towards_functional_repertoire_of_the_earliest_proteins","translated_slug":"","page_count":null,"language":"en","content_type":"Work","summary":"The conserved protein sequence motifs present in all prokaryotic proteomes, \u0026amp;quot;omnipresent motifs,\u0026amp;quot; presumably, correspond to the earliest proteins of the Last Universal Cellular Ancestor, from which all the proteomes have descended. Fifteen proteomes, each representing one of the total 15 diverse phyla of 131 Eubacteria and Archea, from which the omnipresent elements have been originally derived, are exhaustively screened. All those proteins which harbor the omnipresent motifs are identified. Six \u0026amp;quot;omnipresent\u0026amp;quot; protein types are revealed which are located in all 15 proteomes: ABC cassettes, FtsH proteases, translation initiation factors, translation elongation factors, isoleucyl-tRNA synthases, and RNA polymerases β\u0026amp;#39;. In addition to the omnipresent motifs, these proteins also contain other highly conserved motifs, standing for additional modules of the proteins. Remarkably, the identified tentative earliest proteins are responsible for only three basic functions: supply of monomers (ABC transporters and proteases), protein synthesis (initiation and elongation factors, aminoacyl-tRNA synthases), and RNA synthesis (polymerases). No enzymes involved in metabolic activities are present in the list of the earliest proteins derived by this approach. Some of the omnipresent sequence motifs are found, indeed, in the metabolic enzymes (e.g. NTP binding motifs), but these enzymes do not make a sequence matching collection of 15 sequences, i.e. they are not omnipresent. Future analysis of less conserved sequence motifs may reveal at what degree of conservation (stage of evolution) the metabolic enzymes could have entered the scene.","owner":{"id":18191518,"first_name":"Romeu","middle_initials":"C","last_name":"Guimaraes","page_name":"RomeuGuimaraes","domain_name":"cpmtc-igc-ufmg","created_at":"2014-10-08T00:13:53.882-07:00","display_name":"Romeu C Guimaraes","url":"https://cpmtc-igc-ufmg.academia.edu/RomeuGuimaraes"},"attachments":[],"research_interests":[{"id":156,"name":"Genetics","url":"https://www.academia.edu/Documents/in/Genetics"},{"id":3701,"name":"RNA","url":"https://www.academia.edu/Documents/in/RNA"},{"id":4233,"name":"Computational Biology","url":"https://www.academia.edu/Documents/in/Computational_Biology"},{"id":4967,"name":"Molecular Evolution","url":"https://www.academia.edu/Documents/in/Molecular_Evolution"},{"id":7710,"name":"Biology","url":"https://www.academia.edu/Documents/in/Biology"},{"id":26327,"name":"Medicine","url":"https://www.academia.edu/Documents/in/Medicine"},{"id":809881,"name":"Amino Acid Sequence","url":"https://www.academia.edu/Documents/in/Amino_Acid_Sequence"},{"id":857512,"name":"Proteases","url":"https://www.academia.edu/Documents/in/Proteases"},{"id":1035050,"name":"Proteome","url":"https://www.academia.edu/Documents/in/Proteome"},{"id":1588981,"name":"Protein Biosynthesis","url":"https://www.academia.edu/Documents/in/Protein_Biosynthesis"},{"id":1681026,"name":"Biochemistry and cell biology","url":"https://www.academia.edu/Documents/in/Biochemistry_and_cell_biology"},{"id":2467566,"name":"Molecular Sequence Data","url":"https://www.academia.edu/Documents/in/Molecular_Sequence_Data"},{"id":3585436,"name":"conserved sequence ","url":"https://www.academia.edu/Documents/in/conserved_sequence"}],"urls":[{"id":37277896,"url":"http://www.tandfonline.com/doi/pdf/10.1080/10256018808623883"}]}, dispatcherData: dispatcherData }); 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$(this).data('initialized', true); } }); $a.trackClickSource(".js-work-strip-work-link", "profile_work_strip") }); </script> <div class="js-work-strip profile--work_container" data-work-id="111674849"><div class="profile--work_thumbnail hidden-xs"><a class="js-work-strip-work-link" data-click-track="profile-work-strip-thumbnail" href="https://www.academia.edu/111674849/Metabolic_Profile_of_Aged_and_Non_Aged_Alcoholics_Interned_in_Psychiatric_Hospital_in_Brazil"><img alt="Research paper thumbnail of Metabolic Profile of Aged and Non-Aged Alcoholics Interned in Psychiatric Hospital in Brazil" class="work-thumbnail" src="https://attachments.academia-assets.com/109142067/thumbnails/1.jpg" /></a></div><div class="wp-workCard wp-workCard_itemContainer"><div class="wp-workCard_item wp-workCard--title"><a class="js-work-strip-work-link text-gray-darker" data-click-track="profile-work-strip-title" href="https://www.academia.edu/111674849/Metabolic_Profile_of_Aged_and_Non_Aged_Alcoholics_Interned_in_Psychiatric_Hospital_in_Brazil">Metabolic Profile of Aged and Non-Aged Alcoholics Interned in Psychiatric Hospital in Brazil</a></div><div class="wp-workCard_item"><span>Acta Scientific Gastrointestinal Disorders</span><span>, Feb 17, 2020</span></div><div class="wp-workCard_item"><span class="js-work-more-abstract-truncated">Some aspects and characteristics of alcoholism and of the alcoholics are universal while other ma...</span><a class="js-work-more-abstract" data-broccoli-component="work_strip.more_abstract" data-click-track="profile-work-strip-more-abstract" href="javascript:;"><span> more </span><span><i class="fa fa-caret-down"></i></span></a><span class="js-work-more-abstract-untruncated hidden">Some aspects and characteristics of alcoholism and of the alcoholics are universal while other may differ between groups in consequence of the interaction between causal factors of each of the aspects under the influence of alcohol abuse. Statistical surveys have shown an increase in the production of alcoholic beverages of all kinds, and also provide evidence for the per capita alcohol consumption [1]. Such increment in the abusive ingestion of alcohol as severe individual, social and economic consequences, which motivates a growing number of investigations. The World Health Organization (WHO) classifies as aged, in developing countries, individuals higher than 60 years of age. The fraction of aged in the Brazilian population has grown from 4.8% in 1991 to 5.8% in 2000 and 7.4% in 2010 [2]. It is known that there are differences in the patterns of alcoholism according to the age segments, especially between the aged and non-aged groups [3]. 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(2) At the origins of the genetic code, there is (proto)tRNA Dimer-Directed Polymerization  [constitution of (proto)tRNA is not known]. (2a) The flow is slow because syntheses are bi-directional. Dimers are proto-ribosomes: structures that hold tRNAs together and propitiate the transferase reaction. (2b) (proto)tRNAs in the dimers are complementary, equivalent, superposed, coherent. ● An anticodon is at the same time codon for the other ● Products grow at both (proto)tRNAs. (3) Mechanism: Peptide products that are capable of (proto)tRNA binding and stabilization, without disrupting their activities, establish a self-referential self-stimulatory nucleoprotein production system, at the birth of cells. (4) Decoherence: Separation of the members of dimers was provoked by, among other possible interferences (e. g., proteins), intromission of the mRNA strings, which may have originated from enchaining of segments of the (proto)tRNAs <br />(5) At translation (better, transliteration), Ribosome-Directed Polymerization is directional and the flow is fast. Genetic strings (mRNA) are scanned by laterally associated couples (instead of dimers of tRNAs) that enchain the carried amino acids into proteins.</span></div><div class="wp-workCard_item wp-workCard--actions"><span class="work-strip-bookmark-button-container"></span><a id="a7990582f6facd171084adf5327cc2d2" class="wp-workCard--action" rel="nofollow" data-click-track="profile-work-strip-download" data-download="{"attachment_id":53370875,"asset_id":33306926,"asset_type":"Work","button_location":"profile"}" href="https://www.academia.edu/attachments/53370875/download_file?st=MTczNDUxOTc5Miw4LjIyMi4yMDguMTQ2&s=profile"><span><i class="fa fa-arrow-down"></i></span><span>Download</span></a><span class="wp-workCard--action visible-if-viewed-by-owner inline-block" style="display: none;"><span class="js-profile-work-strip-edit-button-wrapper profile-work-strip-edit-button-wrapper" data-work-id="33306926"><a class="js-profile-work-strip-edit-button" tabindex="0"><span><i class="fa fa-pencil"></i></span><span>Edit</span></a></span></span><span id="work-strip-rankings-button-container"></span></div><div class="wp-workCard_item wp-workCard--stats"><span><span><span class="js-view-count view-count u-mr2x" data-work-id="33306926"><i class="fa fa-spinner fa-spin"></i></span><script>$(function () { var workId = 33306926; window.Academia.workViewCountsFetcher.queue(workId, function (count) { var description = window.$h.commaizeInt(count) + " " + window.$h.pluralize(count, 'View'); $(".js-view-count[data-work-id=33306926]").text(description); $(".js-view-count[data-work-id=33306926]").attr('title', description).tooltip(); }); });</script></span></span><span><span class="percentile-widget hidden"><span class="u-mr2x work-percentile"></span></span><script>$(function () { var workId = 33306926; window.Academia.workPercentilesFetcher.queue(workId, function (percentileText) { var container = $(".js-work-strip[data-work-id='33306926']"); container.find('.work-percentile').text(percentileText.charAt(0).toUpperCase() + percentileText.slice(1)); container.find('.percentile-widget').show(); container.find('.percentile-widget').removeClass('hidden'); }); });</script></span><span><script>$(function() { new Works.PaperRankView({ workId: 33306926, container: "", }); });</script></span></div><div id="work-strip-premium-row-container"></div></div></div><script> require.config({ waitSeconds: 90 })(["https://a.academia-assets.com/assets/wow_profile-f77ea15d77ce96025a6048a514272ad8becbad23c641fc2b3bd6e24ca6ff1932.js","https://a.academia-assets.com/assets/work_edit-ad038b8c047c1a8d4fa01b402d530ff93c45fee2137a149a4a5398bc8ad67560.js"], function() { // from javascript_helper.rb var dispatcherData = {} if (true){ window.WowProfile.dispatcher = window.WowProfile.dispatcher || _.clone(Backbone.Events); dispatcherData = { dispatcher: window.WowProfile.dispatcher, downloadLinkId: "a7990582f6facd171084adf5327cc2d2" } } $('.js-work-strip[data-work-id=33306926]').each(function() { if (!$(this).data('initialized')) { new WowProfile.WorkStripView({ el: this, workJSON: {"id":33306926,"title":"The Logic that Emerges from the Self-Referential Genetic Code","translated_title":"","metadata":{"abstract":"(1) The logic of the living is the metabolic flow that is embedded in the universal and geochemical flows. 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