CINXE.COM

<!DOCTYPE html> <html lang="en-US"> <head> <meta charset="UTF-8"> <meta name="viewport" content="width=device-width, initial-scale=1"> <link rel="profile" href="https://gmpg.org/xfn/11"> <link rel="pingback" href="https://www.brighamhealthonamission.org/xmlrpc.php"> <meta name='robots' content='index, follow, max-image-preview:large, max-snippet:-1, max-video-preview:-1' /> <style>img:is([sizes="auto" i], [sizes^="auto," i]) { contain-intrinsic-size: 3000px 1500px }</style>  <title>Mouse PLPP6 Regulates Allergen Sensitization</title> <meta name="description" content="Brigham and Women's Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a polyisoprenyl diphosphate phosphatase that's activated in dendritic cells after airway exposure to an aeroallergen. They suggest PLPP6 is likely a targetable regulatory checkpoint for allergic inflammation." /> <link rel="canonical" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/" /> <meta property="og:locale" content="en_US" /> <meta property="og:type" content="article" /> <meta property="og:title" content="Mouse PLPP6 Regulates Allergen Sensitization" /> <meta property="og:description" content="Brigham and Women's Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a polyisoprenyl diphosphate phosphatase that's activated in dendritic cells after airway exposure to an aeroallergen. They suggest PLPP6 is likely a targetable regulatory checkpoint for allergic inflammation." /> <meta property="og:url" content="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/" /> <meta property="og:site_name" content="Brigham On a Mission" /> <meta property="article:publisher" content="https://www.facebook.com/BrighamandWomensHospital" /> <meta property="article:published_time" content="2023-06-06T04:00:31+00:00" /> <meta property="article:modified_time" content="2024-01-25T21:10:46+00:00" /> <meta property="og:image" content="https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg" /> <meta property="og:image:width" content="300" /> <meta property="og:image:height" content="225" /> <meta property="og:image:type" content="image/jpeg" /> <meta name="author" content="Faith Reidenbach" /> <meta name="twitter:card" content="summary_large_image" /> <meta name="twitter:creator" content="@BrighamWomens" /> <meta name="twitter:site" content="@BrighamWomens" /> <meta name="twitter:label1" content="Written by" /> <meta name="twitter:data1" content="Faith Reidenbach" /> <meta name="twitter:label2" content="Est. reading time" /> <meta name="twitter:data2" content="2 minutes" /> <script type="application/ld+json" class="yoast-schema-graph">{"@context":"https://schema.org","@graph":[{"@type":"Article","@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#article","isPartOf":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/"},"author":{"name":"Faith Reidenbach","@id":"https://www.brighamhealthonamission.org/#/schema/person/4b9967d6f8b443d2bfc1f5771e91574c"},"headline":"Mouse PLPP6 Regulates Allergen Sensitization","datePublished":"2023-06-06T04:00:31+00:00","dateModified":"2024-01-25T21:10:46+00:00","mainEntityOfPage":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/"},"wordCount":340,"commentCount":0,"publisher":{"@id":"https://www.brighamhealthonamission.org/#organization"},"image":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#primaryimage"},"thumbnailUrl":"https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg","articleSection":["Pulmonology"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#respond"]}]},{"@type":"WebPage","@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/","url":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/","name":"Mouse PLPP6 Regulates Allergen Sensitization","isPartOf":{"@id":"https://www.brighamhealthonamission.org/#website"},"primaryImageOfPage":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#primaryimage"},"image":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#primaryimage"},"thumbnailUrl":"https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg","datePublished":"2023-06-06T04:00:31+00:00","dateModified":"2024-01-25T21:10:46+00:00","description":"Brigham and Women's Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a polyisoprenyl diphosphate phosphatase that's activated in dendritic cells after airway exposure to an aeroallergen. They suggest PLPP6 is likely a targetable regulatory checkpoint for allergic inflammation.","breadcrumb":{"@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#primaryimage","url":"https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg","contentUrl":"https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg","width":300,"height":225,"caption":"Dendritic cell, antigen-presenting immune cell, 3D illustration"},{"@type":"BreadcrumbList","@id":"https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https://www.brighamhealthonamission.org/"},{"@type":"ListItem","position":2,"name":"Mouse PLPP6 Regulates Allergen Sensitization"}]},{"@type":"WebSite","@id":"https://www.brighamhealthonamission.org/#website","url":"https://www.brighamhealthonamission.org/","name":"Brigham On a Mission","description":"Latest Clinical & Research News","publisher":{"@id":"https://www.brighamhealthonamission.org/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https://www.brighamhealthonamission.org/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https://www.brighamhealthonamission.org/#organization","name":"Brigham and Women's Hospital","url":"https://www.brighamhealthonamission.org/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https://www.brighamhealthonamission.org/#/schema/logo/image/","url":"https://www.brighamhealthonamission.org/wp-content/uploads/2017/11/cropped-icon.jpg","contentUrl":"https://www.brighamhealthonamission.org/wp-content/uploads/2017/11/cropped-icon.jpg","width":200,"height":199,"caption":"Brigham and Women's Hospital"},"image":{"@id":"https://www.brighamhealthonamission.org/#/schema/logo/image/"},"sameAs":["https://www.facebook.com/BrighamandWomensHospital","https://x.com/BrighamWomens","https://www.instagram.com/brighamandwomens/","https://www.linkedin.com/company/brigham-and-women's-hospital/","https://www.youtube.com/user/Brighamandwomens"]},{"@type":"Person","@id":"https://www.brighamhealthonamission.org/#/schema/person/4b9967d6f8b443d2bfc1f5771e91574c","name":"Faith Reidenbach","description":"None entered"}]}</script>  <link rel='dns-prefetch' href='//stats.wp.com' /> <link rel='dns-prefetch' href='//fonts.googleapis.com' /> <link rel='dns-prefetch' href='//jetpack.wordpress.com' /> <link rel='dns-prefetch' href='//s0.wp.com' /> <link rel='dns-prefetch' href='//public-api.wordpress.com' /> <link rel='dns-prefetch' href='//0.gravatar.com' /> <link rel='dns-prefetch' href='//1.gravatar.com' /> <link rel='dns-prefetch' href='//2.gravatar.com' /> <link rel="alternate" type="application/rss+xml" title="Brigham On a Mission » Feed" href="https://www.brighamhealthonamission.org/feed/" /> <link rel="alternate" type="application/rss+xml" title="Brigham On a Mission » Comments Feed" href="https://www.brighamhealthonamission.org/comments/feed/" /> <link rel="alternate" type="application/rss+xml" title="Brigham On a Mission » Mouse PLPP6 Regulates Allergen Sensitization Comments Feed" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/feed/" /> <script type="text/javascript"> /* <![CDATA[ */ window._wpemojiSettings = {"baseUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/72x72\/","ext":".png","svgUrl":"https:\/\/s.w.org\/images\/core\/emoji\/15.0.3\/svg\/","svgExt":".svg","source":{"concatemoji":"https:\/\/www.brighamhealthonamission.org\/wp-includes\/js\/wp-emoji-release.min.js?ver=6.7.1"}}; /*! This file is auto-generated */ !function(i,n){var o,s,e;function c(e){try{var t={supportTests:e,timestamp:(new Date).valueOf()};sessionStorage.setItem(o,JSON.stringify(t))}catch(e){}}function p(e,t,n){e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(t,0,0);var t=new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data),r=(e.clearRect(0,0,e.canvas.width,e.canvas.height),e.fillText(n,0,0),new Uint32Array(e.getImageData(0,0,e.canvas.width,e.canvas.height).data));return t.every(function(e,t){return e===r[t]})}function u(e,t,n){switch(t){case"flag":return n(e,"\ud83c\udff3\ufe0f\u200d\u26a7\ufe0f","\ud83c\udff3\ufe0f\u200b\u26a7\ufe0f")?!1:!n(e,"\ud83c\uddfa\ud83c\uddf3","\ud83c\uddfa\u200b\ud83c\uddf3")&&!n(e,"\ud83c\udff4\udb40\udc67\udb40\udc62\udb40\udc65\udb40\udc6e\udb40\udc67\udb40\udc7f","\ud83c\udff4\u200b\udb40\udc67\u200b\udb40\udc62\u200b\udb40\udc65\u200b\udb40\udc6e\u200b\udb40\udc67\u200b\udb40\udc7f");case"emoji":return!n(e,"\ud83d\udc26\u200d\u2b1b","\ud83d\udc26\u200b\u2b1b")}return!1}function f(e,t,n){var r="undefined"!=typeof WorkerGlobalScope&&self instanceof WorkerGlobalScope?new OffscreenCanvas(300,150):i.createElement("canvas"),a=r.getContext("2d",{willReadFrequently:!0}),o=(a.textBaseline="top",a.font="600 32px Arial",{});return e.forEach(function(e){o[e]=t(a,e,n)}),o}function t(e){var t=i.createElement("script");t.src=e,t.defer=!0,i.head.appendChild(t)}"undefined"!=typeof Promise&&(o="wpEmojiSettingsSupports",s=["flag","emoji"],n.supports={everything:!0,everythingExceptFlag:!0},e=new Promise(function(e){i.addEventListener("DOMContentLoaded",e,{once:!0})}),new Promise(function(t){var n=function(){try{var e=JSON.parse(sessionStorage.getItem(o));if("object"==typeof e&&"number"==typeof e.timestamp&&(new Date).valueOf()<e.timestamp+604800&&"object"==typeof e.supportTests)return e.supportTests}catch(e){}return null}();if(!n){if("undefined"!=typeof Worker&&"undefined"!=typeof OffscreenCanvas&&"undefined"!=typeof URL&&URL.createObjectURL&&"undefined"!=typeof Blob)try{var e="postMessage("+f.toString()+"("+[JSON.stringify(s),u.toString(),p.toString()].join(",")+"));",r=new Blob([e],{type:"text/javascript"}),a=new Worker(URL.createObjectURL(r),{name:"wpTestEmojiSupports"});return void(a.onmessage=function(e){c(n=e.data),a.terminate(),t(n)})}catch(e){}c(n=f(s,u,p))}t(n)}).then(function(e){for(var t in e)n.supports[t]=e[t],n.supports.everything=n.supports.everything&&n.supports[t],"flag"!==t&&(n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&n.supports[t]);n.supports.everythingExceptFlag=n.supports.everythingExceptFlag&&!n.supports.flag,n.DOMReady=!1,n.readyCallback=function(){n.DOMReady=!0}}).then(function(){return e}).then(function(){var e;n.supports.everything||(n.readyCallback(),(e=n.source||{}).concatemoji?t(e.concatemoji):e.wpemoji&&e.twemoji&&(t(e.twemoji),t(e.wpemoji)))}))}((window,document),window._wpemojiSettings); /* ]]> */ </script> <style id='wp-emoji-styles-inline-css' type='text/css'> img.wp-smiley, img.emoji { display: inline !important; border: none !important; box-shadow: none !important; height: 1em !important; width: 1em !important; margin: 0 0.07em !important; vertical-align: -0.1em !important; background: none !important; padding: 0 !important; } </style> <link rel='stylesheet' id='wp-block-library-css' href='https://www.brighamhealthonamission.org/wp-includes/css/dist/block-library/style.min.css?ver=6.7.1' type='text/css' media='all' /> <link rel='stylesheet' id='mediaelement-css' href='https://www.brighamhealthonamission.org/wp-includes/js/mediaelement/mediaelementplayer-legacy.min.css?ver=4.2.17' type='text/css' media='all' /> <link rel='stylesheet' id='wp-mediaelement-css' href='https://www.brighamhealthonamission.org/wp-includes/js/mediaelement/wp-mediaelement.min.css?ver=6.7.1' type='text/css' media='all' /> <style id='jetpack-sharing-buttons-style-inline-css' type='text/css'> .jetpack-sharing-buttons__services-list{display:flex;flex-direction:row;flex-wrap:wrap;gap:0;list-style-type:none;margin:5px;padding:0}.jetpack-sharing-buttons__services-list.has-small-icon-size{font-size:12px}.jetpack-sharing-buttons__services-list.has-normal-icon-size{font-size:16px}.jetpack-sharing-buttons__services-list.has-large-icon-size{font-size:24px}.jetpack-sharing-buttons__services-list.has-huge-icon-size{font-size:36px}@media print{.jetpack-sharing-buttons__services-list{display:none!important}}.editor-styles-wrapper .wp-block-jetpack-sharing-buttons{gap:0;padding-inline-start:0}ul.jetpack-sharing-buttons__services-list.has-background{padding:1.25em 2.375em} </style> <style id='classic-theme-styles-inline-css' type='text/css'> /*! This file is auto-generated */ .wp-block-button__link{color:#fff;background-color:#32373c;border-radius:9999px;box-shadow:none;text-decoration:none;padding:calc(.667em + 2px) calc(1.333em + 2px);font-size:1.125em}.wp-block-file__button{background:#32373c;color:#fff;text-decoration:none} </style> <style id='global-styles-inline-css' type='text/css'> :root{--wp--preset--aspect-ratio--square: 1;--wp--preset--aspect-ratio--4-3: 4/3;--wp--preset--aspect-ratio--3-4: 3/4;--wp--preset--aspect-ratio--3-2: 3/2;--wp--preset--aspect-ratio--2-3: 2/3;--wp--preset--aspect-ratio--16-9: 16/9;--wp--preset--aspect-ratio--9-16: 9/16;--wp--preset--color--black: #000000;--wp--preset--color--cyan-bluish-gray: #abb8c3;--wp--preset--color--white: #ffffff;--wp--preset--color--pale-pink: #f78da7;--wp--preset--color--vivid-red: #cf2e2e;--wp--preset--color--luminous-vivid-orange: #ff6900;--wp--preset--color--luminous-vivid-amber: #fcb900;--wp--preset--color--light-green-cyan: #7bdcb5;--wp--preset--color--vivid-green-cyan: #00d084;--wp--preset--color--pale-cyan-blue: #8ed1fc;--wp--preset--color--vivid-cyan-blue: #0693e3;--wp--preset--color--vivid-purple: #9b51e0;--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple: linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%);--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan: linear-gradient(135deg,rgb(122,220,180) 0%,rgb(0,208,130) 100%);--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange: linear-gradient(135deg,rgba(252,185,0,1) 0%,rgba(255,105,0,1) 100%);--wp--preset--gradient--luminous-vivid-orange-to-vivid-red: linear-gradient(135deg,rgba(255,105,0,1) 0%,rgb(207,46,46) 100%);--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray: linear-gradient(135deg,rgb(238,238,238) 0%,rgb(169,184,195) 100%);--wp--preset--gradient--cool-to-warm-spectrum: linear-gradient(135deg,rgb(74,234,220) 0%,rgb(151,120,209) 20%,rgb(207,42,186) 40%,rgb(238,44,130) 60%,rgb(251,105,98) 80%,rgb(254,248,76) 100%);--wp--preset--gradient--blush-light-purple: linear-gradient(135deg,rgb(255,206,236) 0%,rgb(152,150,240) 100%);--wp--preset--gradient--blush-bordeaux: linear-gradient(135deg,rgb(254,205,165) 0%,rgb(254,45,45) 50%,rgb(107,0,62) 100%);--wp--preset--gradient--luminous-dusk: linear-gradient(135deg,rgb(255,203,112) 0%,rgb(199,81,192) 50%,rgb(65,88,208) 100%);--wp--preset--gradient--pale-ocean: linear-gradient(135deg,rgb(255,245,203) 0%,rgb(182,227,212) 50%,rgb(51,167,181) 100%);--wp--preset--gradient--electric-grass: linear-gradient(135deg,rgb(202,248,128) 0%,rgb(113,206,126) 100%);--wp--preset--gradient--midnight: linear-gradient(135deg,rgb(2,3,129) 0%,rgb(40,116,252) 100%);--wp--preset--font-size--small: 13px;--wp--preset--font-size--medium: 20px;--wp--preset--font-size--large: 36px;--wp--preset--font-size--x-large: 42px;--wp--preset--spacing--20: 0.44rem;--wp--preset--spacing--30: 0.67rem;--wp--preset--spacing--40: 1rem;--wp--preset--spacing--50: 1.5rem;--wp--preset--spacing--60: 2.25rem;--wp--preset--spacing--70: 3.38rem;--wp--preset--spacing--80: 5.06rem;--wp--preset--shadow--natural: 6px 6px 9px rgba(0, 0, 0, 0.2);--wp--preset--shadow--deep: 12px 12px 50px rgba(0, 0, 0, 0.4);--wp--preset--shadow--sharp: 6px 6px 0px rgba(0, 0, 0, 0.2);--wp--preset--shadow--outlined: 6px 6px 0px -3px rgba(255, 255, 255, 1), 6px 6px rgba(0, 0, 0, 1);--wp--preset--shadow--crisp: 6px 6px 0px rgba(0, 0, 0, 1);}:where(.is-layout-flex){gap: 0.5em;}:where(.is-layout-grid){gap: 0.5em;}body .is-layout-flex{display: flex;}.is-layout-flex{flex-wrap: wrap;align-items: center;}.is-layout-flex > :is(*, div){margin: 0;}body .is-layout-grid{display: grid;}.is-layout-grid > :is(*, div){margin: 0;}:where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;}:where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;}.has-black-color{color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-color{color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-color{color: var(--wp--preset--color--white) !important;}.has-pale-pink-color{color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-color{color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-color{color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-color{color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-color{color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-color{color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-color{color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-color{color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-color{color: var(--wp--preset--color--vivid-purple) !important;}.has-black-background-color{background-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-background-color{background-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-background-color{background-color: var(--wp--preset--color--white) !important;}.has-pale-pink-background-color{background-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-background-color{background-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-background-color{background-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-background-color{background-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-background-color{background-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-background-color{background-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-background-color{background-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-background-color{background-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-background-color{background-color: var(--wp--preset--color--vivid-purple) !important;}.has-black-border-color{border-color: var(--wp--preset--color--black) !important;}.has-cyan-bluish-gray-border-color{border-color: var(--wp--preset--color--cyan-bluish-gray) !important;}.has-white-border-color{border-color: var(--wp--preset--color--white) !important;}.has-pale-pink-border-color{border-color: var(--wp--preset--color--pale-pink) !important;}.has-vivid-red-border-color{border-color: var(--wp--preset--color--vivid-red) !important;}.has-luminous-vivid-orange-border-color{border-color: var(--wp--preset--color--luminous-vivid-orange) !important;}.has-luminous-vivid-amber-border-color{border-color: var(--wp--preset--color--luminous-vivid-amber) !important;}.has-light-green-cyan-border-color{border-color: var(--wp--preset--color--light-green-cyan) !important;}.has-vivid-green-cyan-border-color{border-color: var(--wp--preset--color--vivid-green-cyan) !important;}.has-pale-cyan-blue-border-color{border-color: var(--wp--preset--color--pale-cyan-blue) !important;}.has-vivid-cyan-blue-border-color{border-color: var(--wp--preset--color--vivid-cyan-blue) !important;}.has-vivid-purple-border-color{border-color: var(--wp--preset--color--vivid-purple) !important;}.has-vivid-cyan-blue-to-vivid-purple-gradient-background{background: var(--wp--preset--gradient--vivid-cyan-blue-to-vivid-purple) !important;}.has-light-green-cyan-to-vivid-green-cyan-gradient-background{background: var(--wp--preset--gradient--light-green-cyan-to-vivid-green-cyan) !important;}.has-luminous-vivid-amber-to-luminous-vivid-orange-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-amber-to-luminous-vivid-orange) !important;}.has-luminous-vivid-orange-to-vivid-red-gradient-background{background: var(--wp--preset--gradient--luminous-vivid-orange-to-vivid-red) !important;}.has-very-light-gray-to-cyan-bluish-gray-gradient-background{background: var(--wp--preset--gradient--very-light-gray-to-cyan-bluish-gray) !important;}.has-cool-to-warm-spectrum-gradient-background{background: var(--wp--preset--gradient--cool-to-warm-spectrum) !important;}.has-blush-light-purple-gradient-background{background: var(--wp--preset--gradient--blush-light-purple) !important;}.has-blush-bordeaux-gradient-background{background: var(--wp--preset--gradient--blush-bordeaux) !important;}.has-luminous-dusk-gradient-background{background: var(--wp--preset--gradient--luminous-dusk) !important;}.has-pale-ocean-gradient-background{background: var(--wp--preset--gradient--pale-ocean) !important;}.has-electric-grass-gradient-background{background: var(--wp--preset--gradient--electric-grass) !important;}.has-midnight-gradient-background{background: var(--wp--preset--gradient--midnight) !important;}.has-small-font-size{font-size: var(--wp--preset--font-size--small) !important;}.has-medium-font-size{font-size: var(--wp--preset--font-size--medium) !important;}.has-large-font-size{font-size: var(--wp--preset--font-size--large) !important;}.has-x-large-font-size{font-size: var(--wp--preset--font-size--x-large) !important;} :where(.wp-block-post-template.is-layout-flex){gap: 1.25em;}:where(.wp-block-post-template.is-layout-grid){gap: 1.25em;} :where(.wp-block-columns.is-layout-flex){gap: 2em;}:where(.wp-block-columns.is-layout-grid){gap: 2em;} :root :where(.wp-block-pullquote){font-size: 1.5em;line-height: 1.6;} </style> <link rel='stylesheet' id='widgetopts-styles-css' href='https://www.brighamhealthonamission.org/wp-content/plugins/widget-options/assets/css/widget-options.css?ver=4.0.8' type='text/css' media='all' /> <link crossorigin="anonymous" rel='stylesheet' id='paulie-webfont-css' href='https://fonts.googleapis.com/css?family=Montserrat%3A400%2C700%7CSource+Code+Pro%3A300%2C400%2C700&subset=latin' type='text/css' media='all' /> <link rel='stylesheet' id='paulie-style-css' href='https://www.brighamhealthonamission.org/wp-content/themes/paulie/style.css?ver=6.7.1' type='text/css' media='all' /> <link rel='stylesheet' id='paulie-iconfont-css' href='https://www.brighamhealthonamission.org/wp-content/themes/paulie/css/font-awesome.css?ver=6.7.1' type='text/css' media='all' /> <link rel='stylesheet' id='sharedaddy-css' href='https://www.brighamhealthonamission.org/wp-content/plugins/jetpack/modules/sharedaddy/sharing.css?ver=14.0' type='text/css' media='all' /> <link rel='stylesheet' id='social-logos-css' href='https://www.brighamhealthonamission.org/wp-content/plugins/jetpack/_inc/social-logos/social-logos.min.css?ver=14.0' type='text/css' media='all' /> <script type="text/javascript" src="https://www.brighamhealthonamission.org/wp-includes/js/jquery/jquery.min.js?ver=3.7.1" id="jquery-core-js"></script> <script type="text/javascript" src="https://www.brighamhealthonamission.org/wp-includes/js/jquery/jquery-migrate.min.js?ver=3.4.1" id="jquery-migrate-js"></script> <link rel="https://api.w.org/" href="https://www.brighamhealthonamission.org/wp-json/" /><link rel="alternate" title="JSON" type="application/json" href="https://www.brighamhealthonamission.org/wp-json/wp/v2/posts/7093" /><link rel="EditURI" type="application/rsd+xml" title="RSD" href="https://www.brighamhealthonamission.org/xmlrpc.php?rsd" /> <meta name="generator" content="WordPress 6.7.1" /> <link rel='shortlink' href='https://www.brighamhealthonamission.org/?p=7093' /> <link rel="alternate" title="oEmbed (JSON)" type="application/json+oembed" href="https://www.brighamhealthonamission.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.brighamhealthonamission.org%2F2023%2F06%2F06%2Fmouse-plpp6-regulates-allergen-sensitization%2F" /> <link rel="alternate" title="oEmbed (XML)" type="text/xml+oembed" href="https://www.brighamhealthonamission.org/wp-json/oembed/1.0/embed?url=https%3A%2F%2Fwww.brighamhealthonamission.org%2F2023%2F06%2F06%2Fmouse-plpp6-regulates-allergen-sensitization%2F&format=xml" /> <script type="text/javascript">//<![CDATA[ function external_links_in_new_windows_loop() { if (!document.links) { document.links = document.getElementsByTagName('a'); } var change_link = false; var force = ''; var ignore = ''; for (var t=0; t<document.links.length; t++) { var all_links = document.links[t]; change_link = false; if(document.links[t].hasAttribute('onClick') == false) { // forced if the address starts with http (or also https), but does not link to the current domain if(all_links.href.search(/^http/) != -1 && all_links.href.search('www.brighamhealthonamission.org') == -1 && all_links.href.search(/^#/) == -1) { // console.log('Changed ' + all_links.href); change_link = true; } if(force != '' && all_links.href.search(force) != -1) { // forced // console.log('force ' + all_links.href); change_link = true; } if(ignore != '' && all_links.href.search(ignore) != -1) { // console.log('ignore ' + all_links.href); // ignored change_link = false; } if(change_link == true) { // console.log('Changed ' + all_links.href); document.links[t].setAttribute('onClick', 'javascript:window.open(\'' + all_links.href.replace(/'/g, '') + '\', \'_blank\', \'noopener\'); return false;'); document.links[t].removeAttribute('target'); } } } } // Load function external_links_in_new_windows_load(func) { var oldonload = window.onload; if (typeof window.onload != 'function'){ window.onload = func; } else { window.onload = function(){ oldonload(); func(); } } } external_links_in_new_windows_load(external_links_in_new_windows_loop); //]]></script> <style>img#wpstats{display:none}</style> <style type="text/css"> .image-header { background-image: url("https://www.brighamhealthonamission.org/wp-content/uploads/2022/03/cropped-oam-web-header.jpg"); margin-bottom: 0px; } @media (min-width: 768px) { .image-header { padding: 100px 0px; margin-bottom: 0px; min-height: 325px; } } #page .site-title, #page .site-description { position: absolute; clip: rect(1px, 1px, 1px, 1px); } </style> <link rel="icon" href="https://www.brighamhealthonamission.org/wp-content/uploads/2022/02/mgb-favicon.png" sizes="32x32" /> <link rel="icon" href="https://www.brighamhealthonamission.org/wp-content/uploads/2022/02/mgb-favicon.png" sizes="192x192" /> <link rel="apple-touch-icon" href="https://www.brighamhealthonamission.org/wp-content/uploads/2022/02/mgb-favicon.png" /> <meta name="msapplication-TileImage" content="https://www.brighamhealthonamission.org/wp-content/uploads/2022/02/mgb-favicon.png" /> <style type="text/css" id="wp-custom-css"> /*Hide Category Page Title*/ .category h1.page-title { display: none; } /* add space between each item */ .listing-item { display: block; margin-bottom: 10%; border-bottom: 2px solid; } /*match the blog feed style for title*/ .listing-item a.title { clear: both; font-family: 'Montserrat', Helvetica, sans-serif; text-transform: none; font-weight: 700; line-height: 1.5; color: #333; letter-spacing: 3px; display: block; margin: 40px 0 20px; font-size: 24px; font-size: 1.5rem; text-align: center; border-bottom-style: none; } /* hide the dash */ .listing-item .excerpt-dash { display: none; } /* add space to below the excerpt*/ .listing-item .excerpt { display: block; margin-bottom: 20px; } /* hide author info */ .author.vcard { display: none; } /* Social icon color */ .share-icon, h1.entry-title::after { background-color: #f6bd39 !important; } /* horizontal lines color */ h3::before, .widget-title { border-color: #f6bd39 !important; } .taxonomy-description { text-align: center; } .taxonomy-description p { font-size: 1.125rem; font-family: 'Montserrat', Helvetica, sans-serif; text-transform: uppercase; font-weight: 700; line-height: 3.5; letter-spacing: 3px; display: inline-block; border-bottom: 2px solid #f6bd39; } blockquote p, .comment-navigation a:hover, .navigation .nav-links .nav-previous:hover, .navigation .nav-links .nav-next:hover, input[type=text]:focus, input[type=email]:focus, input[type=password]:focus, textarea:focus, .jetpack_subscription_widget #subscribe-email input:focus, .single .entry-footer .entry-meta, .entry-summary a, .entry-content a, .comment-content a, a.comment-reply-link, .page-links a, .comment-list>li>.comment:before, .comment-list>li.trackback:before, .comment-list>li.pingback:before, .widget-title, #main div#jp-relatedposts div.jp-relatedposts-items .jp-relatedposts-post .jp-relatedposts-post-title a:hover { border-color: #936700; } body, b, strong, h1, h2, h3, h4, h5, h6, .nav-menu .sub-menu a, .nav-menu .sub-menu a:hover, .nav-menu .children a, .nav-menu .children a:hover, .page-title, .archive-title, .entry-title, .entry-title a, .entry-no-title a, .nav-menu li a, .nav-menu li a:hover, .widget-title, .menu-toggle { color: #6d6d6d; } .entry-summary a.more-link { font-family: 'Montserrat', Helvetica, sans-serif; font-weight: 700; color: #000; display: table; padding: 6px 8px; text-decoration: none; text-align: center; border: none !important; outline: 0; background-color: transparent; margin: 0 auto; line-height: 1.5; margin-top: 20px; } #infinite-handle, .infinite-loader { position: absolute; bottom: 30px; right: 0; left: 0; text-align: center; } .nav-menu li a:hover, .nav-menu .current_page_item>a, .nav-menu .current-menu-item>a { border-color: #010d01; border-top-color: rgb(1, 13, 1); border-right-color: rgb(1, 13, 1); border-bottom-color: rgb(1, 13, 1); border-left-color: rgb(1, 13, 1); } .nav-menu .sub-menu, .nav-menu .sub-menu a:hover, .nav-menu .children, .nav-menu .children a:hover { background-color: #e5e5e5; } #colophon, .site-info { background-color: #f6bd39; } .sub-menu li:hover, .sub-menu a:hover{ color: #033A94 !important; } @media (min-width: 1200px){ .nav-menu li:not(.current_page_item) a:not(:hover), .nav-menu li:not(.current_page_item) a:not(:hover) { border-top-color: transparent; }} @media (max-width:768px){ .nav-menu li a:hover, .nav-menu .current_page_item > a, .nav-menu .current-menu-item > a { color: #fff; background-color: #f6bd39 !important; } } body, h1, h2, h3, h4, h5, h6 { font-family: 'Montserrat', Helvetica, sans-serif; } .entry-header a:hover { color: #f6bd39 !important; } </style> </head> <body data-rsssl=1 class="post-template-default single single-post postid-7093 single-format-standard"> <div id="page" class="hfeed site"> <section class="image-header textcenter-xs box"> <a href="https://www.brighamhealthonamission.org/" class="site-logo-link" rel="home" itemprop="url"></a> <h1 class="site-title"><a href="https://www.brighamhealthonamission.org/" rel="home">Brigham On a Mission</a></h1> <p class="site-description">Latest Clinical & Research News</p> </section> <header id="masthead" class="site-header" role="banner"> <div id="navbar" class="navbar"> <div class="container"> <h3 class="menu-toggle"><i class="fa fa-bars"></i><span class="screen-reader-text">Primary Menu</span></h3> <nav id="site-navigation" class="navigation main-navigation" role="navigation"> <div class="menu-primary-container"><ul id="menu-primary" class="nav-menu"><li id="menu-item-3567" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3567"><a href="/">Home</a></li> <li id="menu-item-3747" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-has-children menu-item-3747"><a href="#">Specialties</a> <ul class="sub-menu"> <li id="menu-item-4907" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-4907"><a href="https://www.brighamhealthonamission.org/category/covid-19/">COVID-19</a></li> <li id="menu-item-3575" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3575"><a href="https://www.brighamhealthonamission.org/category/diabetes-endocrinology/">Endocrinology</a></li> <li id="menu-item-3577" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3577"><a href="https://www.brighamhealthonamission.org/category/gastroenterology-gi-surgery/">Gastroenterology & GI Surgery</a></li> <li id="menu-item-3578" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3578"><a href="https://www.brighamhealthonamission.org/category/geriatrics/">Geriatric</a></li> <li id="menu-item-3574" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3574"><a href="https://www.brighamhealthonamission.org/category/cardiology-heart/">Heart & Vascular</a></li> <li id="menu-item-3587" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3587"><a href="https://www.brighamhealthonamission.org/category/neonatology/">Neonatology</a></li> <li id="menu-item-3580" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3580"><a href="https://www.brighamhealthonamission.org/category/nephrology/">Nephrology</a></li> <li id="menu-item-3581" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3581"><a href="https://www.brighamhealthonamission.org/category/neurology-neurosurgery/">Neurology & Neurosurgery</a></li> <li id="menu-item-3579" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3579"><a href="https://www.brighamhealthonamission.org/category/gynecology/">OB/GYN</a></li> <li id="menu-item-3573" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3573"><a href="https://www.brighamhealthonamission.org/category/cancer/">Oncology</a></li> <li id="menu-item-3586" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3586"><a href="https://www.brighamhealthonamission.org/category/orthopaedics/">Orthopaedic Surgery</a></li> <li id="menu-item-3576" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3576"><a href="https://www.brighamhealthonamission.org/category/ear-nose-and-throat/">Otolaryngology</a></li> <li id="menu-item-3582" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3582"><a href="https://www.brighamhealthonamission.org/category/psychiatry/">Psychiatry</a></li> <li id="menu-item-3583" class="menu-item menu-item-type-taxonomy menu-item-object-category current-post-ancestor current-menu-parent current-post-parent menu-item-3583"><a href="https://www.brighamhealthonamission.org/category/pulmonology/">Pulmonary & Thoracic Surgery</a></li> <li id="menu-item-3584" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3584"><a href="https://www.brighamhealthonamission.org/category/rheumatology/">Rheumatology</a></li> <li id="menu-item-3585" class="menu-item menu-item-type-taxonomy menu-item-object-category menu-item-3585"><a href="https://www.brighamhealthonamission.org/category/urology/">Urology</a></li> </ul> </li> <li id="menu-item-3572" class="menu-item menu-item-type-custom menu-item-object-custom menu-item-3572"><a href="http://brighamandwomens.org/medical-professionals/refer-a-patient">Refer a Patient</a></li> </ul></div> </nav> </div> </div> </header> <section id="content" class="site-content"> <div class="container"> <div class="row"> <div id="primary" class="content-area col-md-8"> <main id="main" class="site-main" role="main"> <article id="post-7093" class="post-7093 post type-post status-publish format-standard has-post-thumbnail hentry category-pulmonology"> <header class="entry-header"> <h1 class="entry-title textcenter-xs">Mouse PLPP6 Regulates Allergen Sensitization</h1> <div class="entry-thumbnail"> <img width="300" height="225" src="https://www.brighamhealthonamission.org/wp-content/uploads/2024/01/dendritic-cell-antigen-p.jpg" class="attachment-full size-full wp-post-image" alt="Dendritic cell, antigen-presenting immune cell, 3D illustration" decoding="async" fetchpriority="high" /> </div> </header> <div class="entry-content"> <p>Inhaled particles are sampled by airway dendritic cells (DC) in a process called macropinocytosis. Cholesterol in DC membranes is an important determinant of macropinocytosis and the ability of DCs to internalize and present antigens to prime naive T cells efficiently. These cellular processes in DCs are pivotal to the development of allergy or immune tolerance.</p> <p>Certain polyisoprenyl diphosphates (PIPPs) have a role in cholesterol metabolism and other vital cellular functions, including as intracellular signals for inflammatory responses. One PIPP metabolite is presqualene diphosphate, which upon cell activation, is transiently converted to presqualene monophosphate by an enzyme called phospholipid phosphatase 6 (PLPP6).</p> <p>Brigham and Women’s Hospital researchers are the first to characterize Plpp6, a mouse homolog of PLPP6, as a PIPP phosphatase that is activated in DCs after airway exposure to an aeroallergen. They consider PLPP6 likely to be a targetable regulatory checkpoint for allergic inflammation. <a title="Bruce D. Levy, MD, Profile" href="https://physiciandirectory.brighamandwomens.org/details/1051/bruce-levy-pulmonary_and_critical_care-boston" target="_blank" rel="noopener noreferrer">Bruce D. Levy, MD</a>, interim chair of the <a target="_blank" href="https://www.brighamandwomens.org/department-of-medicine" rel="noopener noreferrer">Department of Medicine</a> and chief of the <a title="The Brigham's Division of Pulmonary and Critical Care Medicine" href="https://www.brighamandwomens.org/medicine/pulmonary-and-critical-care-medicine" target="_blank" rel="noopener noreferrer">Division of Pulmonary and Critical Care Medicine</a> at the Brigham, <a title="Thayse R. Brüggemann, PhD, Profile" href="https://connects.catalyst.harvard.edu/Profiles/display/Person/153276" target="_blank" rel="noopener noreferrer">Thayse R. Brüggemann, PhD</a>, instructor in the Division, and colleagues report in <a title="Mouse phospholipid phosphatase 6 regulates dendritic cell cholesterol, macropinocytosis, and allergen sensitization" href="https://www.cell.com/iscience/fulltext/S2589-0042%2822%2901457-2" target="_blank" rel="noopener noreferrer"><em>iScience</em></a><em>.</em></p> <h2>Principal Findings</h2> <p>The research team’s key observations were:</p> <ul> <li>Mouse Plpp6 was structurally and functionally homologous to human PLPP6</li> <li><em>Plpp6-</em>knockout <em>(Plpp6</em><em><sup>–/–</sup></em><em>)</em> mice exhibited decreased DC cholesterol content and allergen macropinocytosis, which interfered with DC antigen uptake</li> <li>Compared with wild-type mice,<em> Plpp6</em><em><sup>–/–</sup></em> mice displayed decreased lung allergic inflammation in response to house dust mite extract, pointing to a role for DC PLPP6 activity in facilitating early allergen-initiated immune responses</li> <li>When wild-type mice were sensitized with allergen-exposed <em>Plpp6</em><em><sup>–/–</sup></em> DCs, and then were airway challenged with the same allergen, they showed protection from allergic lung inflammation compared with wild-type mice that were sensitized with wild-type DCs</li> </ul> <h2>Laying the Groundwork for Therapies</h2> <p>These data suggest a previously unappreciated role for PLPP6 as a regulator of cell cholesterol, DC macropinocytosis, and allergen-induced lung inflammation. PLPP6 might represent a pharmacological target to modulate cholesterol biosynthesis and excess inflammatory responses to allergens.</p> <script async type="text/javascript" src="//tracking.skyword.com/tracker.js?contentId=281474980226312"></script> <div class="sharedaddy sd-sharing-enabled"><div class="robots-nocontent sd-block sd-social sd-social-icon sd-sharing"><h3 class="sd-title">Share this:</h3><div class="sd-content"><ul><li class="share-linkedin"><a rel="nofollow noopener noreferrer" data-shared="sharing-linkedin-7093" class="share-linkedin sd-button share-icon no-text" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/?share=linkedin" target="_blank" title="Click to share on LinkedIn" ><span></span><span class="sharing-screen-reader-text">Click to share on LinkedIn (Opens in new window)</span></a></li><li class="share-twitter"><a rel="nofollow noopener noreferrer" data-shared="sharing-twitter-7093" class="share-twitter sd-button share-icon no-text" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/?share=twitter" target="_blank" title="Click to share on Twitter" ><span></span><span class="sharing-screen-reader-text">Click to share on Twitter (Opens in new window)</span></a></li><li class="share-facebook"><a rel="nofollow noopener noreferrer" data-shared="sharing-facebook-7093" class="share-facebook sd-button share-icon no-text" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/?share=facebook" target="_blank" title="Click to share on Facebook" ><span></span><span class="sharing-screen-reader-text">Click to share on Facebook (Opens in new window)</span></a></li><li class="share-print"><a rel="nofollow noopener noreferrer" data-shared="" class="share-print sd-button share-icon no-text" href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#print" target="_blank" title="Click to print" ><span></span><span class="sharing-screen-reader-text">Click to print (Opens in new window)</span></a></li><li class="share-email"><a rel="nofollow noopener noreferrer" data-shared="" class="share-email sd-button share-icon no-text" href="mailto:?subject=%5BShared%20Post%5D%20Mouse%20PLPP6%20Regulates%20Allergen%20Sensitization&body=https%3A%2F%2Fwww.brighamhealthonamission.org%2F2023%2F06%2F06%2Fmouse-plpp6-regulates-allergen-sensitization%2F&share=email" target="_blank" title="Click to email a link to a friend" data-email-share-error-title="Do you have email set up?" data-email-share-error-text="If you're having problems sharing via email, you might not have email set up for your browser. You may need to create a new email yourself." data-email-share-nonce="331829aa84" data-email-share-track-url="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/?share=email"><span></span><span class="sharing-screen-reader-text">Click to email a link to a friend (Opens in new window)</span></a></li><li class="share-end"></li></ul></div></div></div> </div> <footer class="entry-footer"> <div class="entry-meta textcenter-xs"> <span class="categories-links"><i class="fa fa-bookmark-o"></i><a href="https://www.brighamhealthonamission.org/category/pulmonology/" rel="category tag">Pulmonology</a></span><span class="author vcard"><i class="fa fa-diamond"></i><a class="url fn n" href="https://www.brighamhealthonamission.org/author/sw-77411/" title="View all posts by Faith Reidenbach" rel="author">Faith Reidenbach</a></span><span class="post-comments"><i class="fa fa-heart-o"></i><a href="https://www.brighamhealthonamission.org/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#respond" class="comments-link" >0 comments</a></span> </div> </footer> </article> <nav class="navigation post-navigation" aria-label="Posts"> <h2 class="screen-reader-text">Post navigation</h2> <div class="nav-links"><div class="nav-previous"><a href="https://www.brighamhealthonamission.org/2023/06/05/inflammation-versus-ldl-cholesterol-as-predictor-of-cv-events-in-patients-using-statins/" rel="prev">Inflammation Versus LDL Cholesterol As Predictor of CV Events in Patients Using Statins</a></div><div class="nav-next"><a href="https://www.brighamhealthonamission.org/2023/06/07/paxlovid-reduces-covid-19-hospitalization-among-vaccinated-older-adults/" rel="next">Paxlovid Reduces COVID-19 Hospitalization Among Vaccinated Older Adults</a></div></div> </nav> <div id="comments" class="comments-area"> <div id="respond" class="comment-respond"> <h3 id="reply-title" class="comment-reply-title">Leave a Reply<small><a rel="nofollow" id="cancel-comment-reply-link" href="/2023/06/06/mouse-plpp6-regulates-allergen-sensitization/#respond" style="display:none;">Cancel reply</a></small></h3> <form id="commentform" class="comment-form"> <iframe title="Comment Form" src="https://jetpack.wordpress.com/jetpack-comment/?blogid=166336109&postid=7093&comment_registration=0&require_name_email=1&stc_enabled=0&stb_enabled=0&show_avatars=0&avatar_default=mystery&greeting=Leave+a+Reply&jetpack_comments_nonce=6791b21b8b&greeting_reply=Leave+a+Reply+to+%25s&color_scheme=transparent&lang=en_US&jetpack_version=14.0&iframe_unique_id=1&show_cookie_consent=10&has_cookie_consent=0&is_current_user_subscribed=0&token_key=%3Bnormal%3B&sig=4e11c141311bb37dda87e86939777d77b5a79422#parent=https%3A%2F%2Fwww.brighamhealthonamission.org%2F2023%2F06%2F06%2Fmouse-plpp6-regulates-allergen-sensitization%2F" name="jetpack_remote_comment" style="width:100%; height: 430px; border:0;" class="jetpack_remote_comment" id="jetpack_remote_comment" sandbox="allow-same-origin allow-top-navigation allow-scripts allow-forms allow-popups" > </iframe>  <script> document.addEventListener('DOMContentLoaded', function () { var commentForms = document.getElementsByClassName('jetpack_remote_comment'); for (var i = 0; i < commentForms.length; i++) { commentForms[i].allowTransparency = true; commentForms[i].scrolling = 'no'; } }); </script>  </form> </div> <input type="hidden" name="comment_parent" id="comment_parent" value="" /> </div> </main> </div> <div id="secondary" class="sidebar col-sm-10 col-sm-offset-1 col-md-3 col-md-offset-1" role="complementary"> <aside id="text-4" class="widget widget_text"> <div class="textwidget"><p><a href="https://www.brighamandwomens.org/?utm_source=oam&utm_medium=blog&utm_campaign=bwhlogo"><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-5622" src="https://www.brighamhealthonamission.org/wp-content/uploads/2021/09/bwh-logo-new-300px.png" alt="Brigham and Women's Hospital" width="300" height="35" /></a></p> </div> </aside><aside id="text-5" class="widget widget_text"> <div class="textwidget"><p><a href="https://www.brighamandwomens.org/campaigns/physicians/overview" target="_blank" rel="noopener"><img loading="lazy" decoding="async" class="aligncenter size-full wp-image-2276" src="https://www.brighamhealthonamission.org/wp-content/uploads/2019/02/blog-button.jpg" alt="read more" width="258" height="155" /></a></p> </div> </aside><aside id="search-4" class="widget widget_search"><h3 class="widget-title">Search</h3> <form method="get" id="searchform" action="https://www.brighamhealthonamission.org/"> <label for="s" class="screen-reader-text"><span>Search</span></label> <input type="text" class="field" name="s" id="s" placeholder="Search …" /> <button type="submit" class="submit fa fa-search" name="submit" id="searchsubmit"><span class="screen-reader-text">Submit</span></button> </form> </aside><aside id="text-7" class="widget widget_text"><h3 class="widget-title">About Brigham On A Mission</h3> <div class="textwidget"><p>This site features news for physicians about research, innovation and clinical care at Brigham and Women’s Hospital.</p> </div> </aside><aside id="text-9" class="widget widget_text"> <div class="textwidget"><p><a href="https://www.brighamandwomens.org/medical-professionals/refer-a-patient?utm_source=oam&utm_medium=blog&utm_campaign=referral"><img decoding="async" src="https://www.brighamhealthonamission.org/wp-content/uploads/2020/10/vl_button.jpg" alt="refer a patient" /></a></p> </div> </aside></div> </div> </div> </section> <footer id="colophon" class="site-footer" role="contentinfo"> <div class="site-info"> <div class="container"> <div class="row"> <div class="col-md-12"> </div> </div> </div> </div> </footer> </div>  <script type="text/javascript"> (function(window, document, dataLayerName, id) { window[dataLayerName]=window[dataLayerName]||[],window[dataLayerName].push({start:(new Date).getTime(),event:"stg.start"});var scripts=document.getElementsByTagName('script')[0],tags=document.createElement('script'); function stgCreateCookie(a,b,c){var d="";if(c){var e=new Date;e.setTime(e.getTime()+24*c*60*60*1e3),d="; expires="+e.toUTCString()}document.cookie=a+"="+b+d+"; path=/"} var isStgDebug=(window.location.href.match("stg_debug")||document.cookie.match("stg_debug"))&&!window.location.href.match("stg_disable_debug");stgCreateCookie("stg_debug",isStgDebug?1:"",isStgDebug?14:-1); var qP=[];dataLayerName!=="dataLayer"&&qP.push("data_layer_name="+dataLayerName),isStgDebug&&qP.push("stg_debug");var qPString=qP.length>0?("?"+qP.join("&")):""; tags.async=!0,tags.src="https://mgb.containers.piwik.pro/"+id+".js"+qPString,scripts.parentNode.insertBefore(tags,scripts); !function(a,n,i){a[n]=a[n]||{};for(var c=0;c<i.length;c++)!function(i){a[n][i]=a[n][i]||{},a[n][i].api=a[n][i].api||function(){var a=[].slice.call(arguments,0);"string"==typeof a[0]&&window[dataLayerName].push({event:n+"."+i+":"+a[0],parameters:[].slice.call(arguments,1)})}}(i[c])}(window,"ppms",["tm","cm"]); })(window, document, 'dataLayer', 'eb15999a-801a-420b-83fe-a6ec50f8d268'); </script>  <script type="text/javascript"> window.WPCOM_sharing_counts = {"https:\/\/www.brighamhealthonamission.org\/2023\/06\/06\/mouse-plpp6-regulates-allergen-sensitization\/":7093}; </script> <script type="text/javascript" src="https://www.brighamhealthonamission.org/wp-content/plugins/widget-options/assets/js/widgetopts.resize.js?ver=4.0.8" id="widgetopts-resize-script-js"></script> <script type="text/javascript" src="https://www.brighamhealthonamission.org/wp-content/themes/paulie/js/functions.js?ver=6.7.1" id="paulie-script-js"></script> <script type="text/javascript" src="https://stats.wp.com/e-202447.js" id="jetpack-stats-js" data-wp-strategy="defer"></script> <script type="text/javascript" id="jetpack-stats-js-after"> /* <![CDATA[ */ _stq = window._stq || []; _stq.push([ "view", JSON.parse("{\"v\":\"ext\",\"blog\":\"166336109\",\"post\":\"7093\",\"tz\":\"-5\",\"srv\":\"www.brighamhealthonamission.org\",\"j\":\"1:14.0\"}") ]); _stq.push([ "clickTrackerInit", "166336109", "7093" ]); /* ]]> */ </script> <script defer type="text/javascript" src="https://www.brighamhealthonamission.org/wp-content/plugins/akismet/_inc/akismet-frontend.js?ver=1732004009" id="akismet-frontend-js"></script> <script type="text/javascript" id="sharing-js-js-extra"> /* <![CDATA[ */ var sharing_js_options = {"lang":"en","counts":"1","is_stats_active":"1"}; /* ]]> */ </script> <script type="text/javascript" src="https://www.brighamhealthonamission.org/wp-content/plugins/jetpack/_inc/build/sharedaddy/sharing.min.js?ver=14.0" id="sharing-js-js"></script> <script type="text/javascript" id="sharing-js-js-after"> /* <![CDATA[ */ var windowOpen; ( function () { function matches( el, sel ) { return !! ( el.matches && el.matches( sel ) || el.msMatchesSelector && el.msMatchesSelector( sel ) ); } document.body.addEventListener( 'click', function ( event ) { if ( ! event.target ) { return; } var el; if ( matches( event.target, 'a.share-linkedin' ) ) { el = event.target; } else if ( event.target.parentNode && matches( event.target.parentNode, 'a.share-linkedin' ) ) { el = event.target.parentNode; } if ( el ) { event.preventDefault(); // If there's another sharing window open, close it. if ( typeof windowOpen !== 'undefined' ) { windowOpen.close(); } windowOpen = window.open( el.getAttribute( 'href' ), 'wpcomlinkedin', 'menubar=1,resizable=1,width=580,height=450' ); return false; } } ); } )(); var windowOpen; ( function () { function matches( el, sel ) { return !! ( el.matches && el.matches( sel ) || el.msMatchesSelector && el.msMatchesSelector( sel ) ); } document.body.addEventListener( 'click', function ( event ) { if ( ! event.target ) { return; } var el; if ( matches( event.target, 'a.share-twitter' ) ) { el = event.target; } else if ( event.target.parentNode && matches( event.target.parentNode, 'a.share-twitter' ) ) { el = event.target.parentNode; } if ( el ) { event.preventDefault(); // If there's another sharing window open, close it. if ( typeof windowOpen !== 'undefined' ) { windowOpen.close(); } windowOpen = window.open( el.getAttribute( 'href' ), 'wpcomtwitter', 'menubar=1,resizable=1,width=600,height=350' ); return false; } } ); } )(); var windowOpen; ( function () { function matches( el, sel ) { return !! ( el.matches && el.matches( sel ) || el.msMatchesSelector && el.msMatchesSelector( sel ) ); } document.body.addEventListener( 'click', function ( event ) { if ( ! event.target ) { return; } var el; if ( matches( event.target, 'a.share-facebook' ) ) { el = event.target; } else if ( event.target.parentNode && matches( event.target.parentNode, 'a.share-facebook' ) ) { el = event.target.parentNode; } if ( el ) { event.preventDefault(); // If there's another sharing window open, close it. if ( typeof windowOpen !== 'undefined' ) { windowOpen.close(); } windowOpen = window.open( el.getAttribute( 'href' ), 'wpcomfacebook', 'menubar=1,resizable=1,width=600,height=400' ); return false; } } ); } )(); /* ]]> */ </script> <script type="text/javascript"> (function () { const iframe = document.getElementById( 'jetpack_remote_comment' ); const commentIframes = document.getElementsByClassName('jetpack_remote_comment'); window.addEventListener('message', function(event) { if (event.origin !== 'https://jetpack.wordpress.com') { return; } if (!event?.data?.iframeUniqueId && !event?.data?.height) { return; } const eventDataUniqueId = event.data.iframeUniqueId; // Change height for the matching comment iframe for (let i = 0; i < commentIframes.length; i++) { const iframe = commentIframes[i]; const url = new URL(iframe.src); const iframeUniqueIdParam = url.searchParams.get('iframe_unique_id'); if (iframeUniqueIdParam == event.data.iframeUniqueId) { iframe.style.height = event.data.height + 'px'; return; } } }); })(); </script> </body> </html>