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<!DOCTYPE html> <html lang="en" class="no-js"> <head> <meta charset="UTF-8"> <meta http-equiv="X-UA-Compatible" content="IE=edge"> <meta name="applicable-device" content="pc,mobile"> <meta name="viewport" content="width=device-width, initial-scale=1"> <meta name="robots" content="max-image-preview:large"> <meta name="access" content="No"> <meta name="360-site-verification" content="1268d79b5e96aecf3ff2a7dac04ad990" /> <title>Immune-suppressive properties of the tumor microenvironment | Cancer Immunology, Immunotherapy </title> <meta name="twitter:site" content="@SpringerLink"/> <meta name="twitter:card" content="summary_large_image"/> <meta name="twitter:image:alt" content="Content cover image"/> <meta name="twitter:title" content="Immune-suppressive properties of the tumor microenvironment"/> <meta name="twitter:description" content="Cancer Immunology, Immunotherapy - Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells...."/> <meta name="twitter:image" content="https://static-content.springer.com/image/art%3A10.1007%2Fs00262-013-1434-6/MediaObjects/262_2013_1434_Fig1_HTML.gif"/> <meta name="journal_id" content="262"/> <meta name="dc.title" content="Immune-suppressive properties of the tumor microenvironment"/> <meta name="dc.source" content="Cancer Immunology, Immunotherapy 2013 62:7"/> <meta name="dc.format" content="text/html"/> <meta name="dc.publisher" content="Springer"/> <meta name="dc.date" content="2013-05-11"/> <meta name="dc.type" content="ReviewPaper"/> <meta name="dc.language" content="En"/> <meta name="dc.copyright" content="2013 Springer-Verlag Berlin Heidelberg"/> <meta name="dc.rights" content="2013 Springer-Verlag Berlin Heidelberg"/> <meta name="dc.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="dc.description" content="Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. Here, we will focus on immune-modulating capacities of the tumor microenvironment."/> <meta name="prism.issn" content="1432-0851"/> <meta name="prism.publicationName" content="Cancer Immunology, Immunotherapy"/> <meta name="prism.publicationDate" content="2013-05-11"/> <meta name="prism.volume" content="62"/> <meta name="prism.number" content="7"/> <meta name="prism.section" content="ReviewPaper"/> <meta name="prism.startingPage" content="1137"/> <meta name="prism.endingPage" content="1148"/> <meta name="prism.copyright" content="2013 Springer-Verlag Berlin Heidelberg"/> <meta name="prism.rightsAgent" content="journalpermissions@springernature.com"/> <meta name="prism.url" content="https://link.springer.com/article/10.1007/s00262-013-1434-6"/> <meta name="prism.doi" content="doi:10.1007/s00262-013-1434-6"/> <meta name="citation_pdf_url" content="https://link.springer.com/content/pdf/10.1007/s00262-013-1434-6.pdf"/> <meta name="citation_fulltext_html_url" content="https://link.springer.com/article/10.1007/s00262-013-1434-6"/> <meta name="citation_journal_title" content="Cancer Immunology, Immunotherapy"/> <meta name="citation_journal_abbrev" content="Cancer Immunol Immunother"/> <meta name="citation_publisher" content="Springer-Verlag"/> <meta name="citation_issn" content="1432-0851"/> <meta name="citation_title" content="Immune-suppressive properties of the tumor microenvironment"/> <meta name="citation_volume" content="62"/> <meta name="citation_issue" content="7"/> <meta name="citation_publication_date" content="2013/07"/> <meta name="citation_online_date" content="2013/05/11"/> <meta name="citation_firstpage" content="1137"/> <meta name="citation_lastpage" content="1148"/> <meta name="citation_article_type" content="Review"/> <meta name="citation_language" content="en"/> <meta name="dc.identifier" content="doi:10.1007/s00262-013-1434-6"/> <meta name="DOI" content="10.1007/s00262-013-1434-6"/> <meta name="size" content="212087"/> <meta name="citation_doi" content="10.1007/s00262-013-1434-6"/> <meta name="citation_springer_api_url" content="http://api.springer.com/xmldata/jats?q=doi:10.1007/s00262-013-1434-6&api_key="/> <meta name="description" content="Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host"/> <meta name="dc.creator" content="Becker, Jürgen C."/> <meta name="dc.creator" content="Andersen, Mads Hald"/> <meta name="dc.creator" content="Schrama, David"/> <meta name="dc.creator" content="thor Straten, Per"/> <meta name="dc.subject" content="Oncology"/> <meta name="dc.subject" content="Immunology"/> <meta name="dc.subject" content="Cancer Research"/> <meta name="citation_reference" content="citation_journal_title=Cell; citation_title=Hallmarks of cancer: the next generation; citation_author=D Hanahan, RA Weinberg; citation_volume=144; citation_publication_date=2011; citation_pages=646-674; citation_doi=10.1016/j.cell.2011.02.013; citation_id=CR1"/> <meta name="citation_reference" content="citation_journal_title=Exp Cell Res; citation_title=Hallmarks of cancer: interactions with the tumor stroma; citation_author=K Pietras, A Östman; citation_volume=316; citation_publication_date=2010; 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citation_author=HC Heyde, I Gramaglia, V Combes; citation_volume=699; citation_publication_date=2011; citation_pages=337-354; citation_doi=10.1007/978-1-61737-950-5_16; citation_id=CR82"/> <meta name="citation_reference" content="citation_journal_title=Biochem Soc Trans; citation_title=Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes); citation_author=TL Whiteside; citation_volume=41; citation_publication_date=2013; citation_pages=245-251; citation_doi=10.1042/BST20120265; citation_id=CR83"/> <meta name="citation_reference" content="citation_journal_title=Int J Cancer; citation_title=Induction of myeloid-derived suppressor cells by tumor exosomes; citation_author=X Xiang, A Poliakov, C Liu; citation_volume=124; citation_publication_date=2009; citation_pages=2621-2633; citation_doi=10.1002/ijc.24249; citation_id=CR84"/> <meta name="citation_author" content="Becker, Jürgen C."/> <meta name="citation_author_email" content="juergen.becker@medunigraz.at"/> <meta name="citation_author_institution" content="Department of General Dermatology, Medical University of Graz, Graz, Austria"/> <meta name="citation_author" content="Andersen, Mads Hald"/> <meta name="citation_author_institution" content="Department of Hematology, Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Herlev, Denmark"/> <meta name="citation_author" content="Schrama, David"/> <meta name="citation_author_institution" content="Department of General Dermatology, Medical University of Graz, Graz, Austria"/> <meta name="citation_author" content="thor Straten, Per"/> <meta name="citation_author_institution" content="Department of Hematology, Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Herlev, Denmark"/> <meta name="format-detection" content="telephone=no"/> <meta name="citation_cover_date" content="2013/07/01"/> <meta property="og:url" content="https://link.springer.com/article/10.1007/s00262-013-1434-6"/> <meta property="og:type" content="article"/> <meta property="og:site_name" content="SpringerLink"/> <meta property="og:title" content="Immune-suppressive properties of the tumor microenvironment - Cancer Immunology, Immunotherapy"/> <meta property="og:description" content="Solid tumors are more than an accumulation of cancer cells. Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. 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Indeed, cancerous cells create a permissive microenvironment by exploiting non-transformed host cells. Thus, solid tumors rather resemble abnormal organs composed of the cancerous cells itself and the stroma providing the supportive framework. The stroma can be divided into the extracellular matrix consisting of proteoglycans, hyaluronic acid, and fibrous proteins, as well as stromal cells including mesenchymal and immune cells; moreover, it contains various peptide factors and metabolites. 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Becker is a paid Advisor for and Member of the Speakers Bureau of Bristol-Myers Squibb, Glaxo-Smith-Kline, Leo Pharma, and Novartis. All other authors do not have any conflict of interest.</p></div></div></section><section aria-labelledby="author-information" data-title="Author information"><div class="c-article-section" id="author-information-section"><h2 class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="author-information">Author information</h2><div class="c-article-section__content" id="author-information-content"><h3 class="c-article__sub-heading" id="affiliations">Authors and Affiliations</h3><ol class="c-article-author-affiliation__list"><li id="Aff1"><p class="c-article-author-affiliation__address">Department of General Dermatology, Medical University of Graz, Auenbruggerplatz 8, 8010, Graz, Austria</p><p class="c-article-author-affiliation__authors-list">Jürgen C. Becker & David Schrama</p></li><li id="Aff2"><p class="c-article-author-affiliation__address">Department of Hematology, Center for Cancer Immune Therapy (CCIT), University Hospital Herlev, Herlev Ringvej 75, 2730, Herlev, Denmark</p><p class="c-article-author-affiliation__authors-list">Mads Hald Andersen & Per thor Straten</p></li></ol><div class="u-js-hide u-hide-print" data-test="author-info"><span class="c-article__sub-heading">Authors</span><ol class="c-article-authors-search u-list-reset"><li id="auth-J_rgen_C_-Becker-Aff1"><span class="c-article-authors-search__title u-h3 js-search-name">Jürgen C. 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class="c-article-section__title js-section-title js-c-reading-companion-sections-item" id="article-info">About this article</h2><div class="c-article-section__content" id="article-info-content"><div class="c-bibliographic-information"><div class="c-bibliographic-information__column"><h3 class="c-article__sub-heading" id="citeas">Cite this article</h3><p class="c-bibliographic-information__citation">Becker, J.C., Andersen, M.H., Schrama, D. <i>et al.</i> Immune-suppressive properties of the tumor microenvironment. <i>Cancer Immunol Immunother</i> <b>62</b>, 1137–1148 (2013). https://doi.org/10.1007/s00262-013-1434-6</p><p class="c-bibliographic-information__download-citation u-hide-print"><a data-test="citation-link" data-track="click" data-track-action="download article citation" data-track-label="link" data-track-external="" rel="nofollow" href="https://citation-needed.springer.com/v2/references/10.1007/s00262-013-1434-6?format=refman&flavour=citation">Download citation<svg width="16" 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