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Poly(3-hydroxybutyrate) (PHB), the most studied of the PHAs, is available as industrial grade and it is considered as viable alternative of petroleum-based materials. However, PHB and cellulose themselves have no antibacterial activity to prevent bacterial infections associated with medical devices that constitute the most important cause of hospital death which could be prevented. The scope of this project is to obtain PHB/NC biocomposites with antibacterial activity using eco-friendly submerged liquid plasma (SLP) and nanotechnology. The research topic of plasma submerged in liquids is new but very important for the functionalization of nanaomaterials or synthesis of unconventional polymers with valuable properties for biomedical applications. In the frame of CELLAB-SLP, the biomaterial and eco-friendly technology will constitute the experimental model that will be developed and tested at lab-scale. </p> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion3" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Objectives</a> </div> <div class=" collapse" id="demoaccordion3"> <div class="accordion-inner" align="justify"> <p>The objective of the project is to develop a new biomaterial with integrated antibacterial activity and a technology to obtain this biomaterial. The new biocomposite must have (i) good processability by compression, extrusion or injection molding in films, plates, tubes or rods as models for biomedical devices; (ii) good mechanical properties and thermal stability; (iii) strong and persistent antibacterial activity beside biocompatibility.</p> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion4" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> </a> </div> <div class=" collapse" id="demoaccordion4"> <div class="accordion-inner" align="justify"> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion5" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Estimated results</a> </div> <div class=" collapse" id="demoaccordion5"> <div class="accordion-inner" align="justify"> <p>The new biomaterial which will be developed in the frame of this project (lab-prototype) and the technology will be patented. The non-patentable results will be disseminated by conferences and articles</p> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion6" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Team members</a> </div> <div class=" collapse" id="demoaccordion6"> <div class="accordion-inner" align="justify"> <p><strong>ICECHIM:</strong></p> <p>Panaitescu Denis</p> <p>Vuluga Zina</p> <p>Corobea Mihai</p> <p>Frone Adriana</p> <p>Chiulan Ioana</p> <p>Bogdan Trica</p> <p>Nicolae Cristian</p> <p>Purcar Violeta</p> <p>Gabor Raluca</p> <p>Iorga Michaela</p> <p>Florea Dorel</p> <p>Radu Dorian</p> <p>Corduneanu Gabriela</p> <p>Anghel Aurelia</p> <p> </p> <p><strong>INFLPR</strong></p> <p>Vizireanu Sorin</p> <p>Dinescu Gheorghe</p> <p>Mitu Bogdana</p> <p>Ionita Rosini</p> <p>Ionita Maria</p> <p>Stoica Daniel</p> <p>Satulu Veronica</p> <p>Teodorescu Maximilian</p> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion7" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Phases</a> </div> <div class=" collapse" id="demoaccordion7"> <div class="accordion-inner" align="justify"> <ol type="1" start="1"> <li>Surface modification of nanocellulose by plasma treatment in contact or submerge in liquids; Synthesis of new PHB/NC biomaterials with antibacterial activity using plasma treatment; Design of the SLP process parameters for controlled composition;</li> <li>Plasma treatment of PHB/NC biomaterials; Antibacterial tests; Prototype built in the lab; Elaboration and validation of laboratory technology; </li> </ol> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion8" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Dissemination</a> </div> <div class=" collapse" id="demoaccordion8"> <div class="accordion-inner" align="justify"> <p><strong><em>Articles</em></strong></p> <p>1. Panaitescu DM, Lupescu I, Frone AN, Chiulan I, Nicolae CA, Tofan V, Stefaniu A, Somoghi R, Trusca R., Medium chain-length polyhydroxyalkanoate copolymer modified by bacterial cellulose for medical devices. Biomacromolecules. 2017 Oct 9;18(10):3222-3232. doi: 10.1021/acs.biomac.7b00855.</p> <p>2. Ioana Chiulan, Adriana Nicoleta Frone, Denis Mihaela Panaitescu, Cristian Andi Nicolae, Roxana Trusca, Surface properties, thermal and mechanical characteristics of poly(vinyl alcohol) – starch - bacterial cellulose composite films, J. Appl. Polym. Sci. 2018, 135, 45800. doi: 10.1002/app.45800.</p> <p>3. Vizireanu, S., Ionita, M.D., Ionita, R.E., Stoica, S.D., Teodorescu, C.M., Husanu, M.A., Apostol, N.G., Baibarac, M., Panaitescu, D., Dinescu, G., Aging phenomena and wettability control of plasma deposited carbon nanowall layers, Plasma Processes and Polymers, 2017, 14(11).</p> <p> </p> <p><strong><em>Invited lecture</em></strong></p> <p>1. S. Vizireanu, S.D. Stoica, M.D. Ionita, A. Lazea Stoyanova, L. Nistor, G. Dinescu, Plasma Fabrication, Functionalization and Application of Vertically Oriented Graphene, Twentieth international summer school on vacuum, electron and ion technology, Sozopol, Bulgaria, 25-29/09/2017</p> <p> </p> <p> </p> <p><strong><em>Conferences</em></strong></p> <p>1. D. M. Panaitescu, I. Lupescu, A. N. Frone, I. Chiulan, C. Nicolae, Z. Vuluga, R. Gabor, G. Dinescu, S. Vizireanu, D. Ionita, A. Casarica, Polyhydroxyalkanoate/bacterial cellulose nanofibers biocomposites with modified surface properties, Fifth International Symposium <em>Frontiers in Polymer Science</em> 17-19 May 2017, Seville, Spain.</p> <p>2. Denis Panaitescu, Adriana Frone, Sorin Vizireanu, George Dinescu, Ioana Chiulan, Cristian Nicolae, Daniela Ionita, Lavinia Carpen, Cosmin Corobea, Violeta Purcar, Cellulose with modified surface properties by plasma treatment, 19th International Conference on Advanced Materials, ROCAM 2017</p> <p>3. S. Vizireanu, M.D. Ionita, E. R. Ionita, S.D. Stoica, L. Carpen, M. Teodorescu, I. Ion, D. Panaitescu, G. Dinescu, Nanomaterials processing by plasma in liquids, P6-01, Conference on Plasma Physics and Applications, Magurele, Bucharest, Romania, 15-20/06/2017.</p> <p>4. V. Satulu, B. Mitu, S. Vizireanu, M. Pandele, S.I. Voicu, L. Kravets, G. Dinescu/Synthesis of composite membranes by RF magnetron sputtering/ RICCCE 20 - 20th Romanian International Conference on Chemistry and Chemical Engineering, Poaiana Brasov Romania, 6-9/09/2017.</p> <p>5. L.G. Carpen, M. Teodorescu, M.D. Ionita, E.R. Ionita, G. Dinescu, Diagnostic of plasma-liquid mixing and methylene blue decomposition using a RF atmospheric jet, International Conference on Plasmas with Liquids (ICPL 2017), March 5-9, 2017, Prague Czech Republic.</p> <p>6. S. Vizireanu, M.D. Ionita, S. D. Stoica, M. M. Ionita, Ioana Mitu, L. C. Nistor, G. Dinescu, Nitrogen incorporation in reduced graphene oxide suspension by submerged plasma jet International Conference on Plasmas with Liquids (ICPL 2017), March 5-9, 2017, Prague Czech Republic.</p> <p>7. S. Vizirean, S.D. Stoica, M. D. Ionita, A. Lazea Stoyanova, L.C. Nistor, G. Dinescu/ Plasma synthesis and treatment for obtaining functional hybrid nanomaterials/, 5th International Conference on Multifunctional, Hybrid and Nanomaterials, Lisabon, Portugalia, 6-10/03/2017</p> <p>8. S. Vizireanu, M.D. Ionita, S. D. Stoica, L. Carpen, M. Teodorescu, I. Ion, M. Ionita, G. Dinescu, Functionalization of reduced graphene oxide suspension by submerged plasma jet, conferinta European Graphene Forum, Paris, Franta, 26-29/04/2017</p> </div> </div> </div> <div class="accordion-group"> <div class="accordion-heading"> <a href="#demoaccordion9" data-parent="#demoaccordion" data-toggle="collapse" class="accordion-toggle"> Phase 1</a> </div> <div class=" collapse" id="demoaccordion9"> <div class="accordion-inner" align="justify"> <p><strong><em>Phase 1/2017 – </em></strong><strong><em>Surface modification of nanocellulose by plasma treatment in contact or submerge in liquids; Synthesis of new PHB/NC biomaterials with antibacterial activity using plasma treatment; Design of the SLP process parameters for controlled composition.</em></strong></p> <p><strong>Duration: 03/01/2017 - 29/12/2017</strong></p> <p><strong>Expected results: </strong></p> <p>-          Parameter values for plasma systems in liquid (power, flow range, treatment time, gases);</p> <p><strong>-          </strong>PHB composites with NC modified in various working conditions;</p> <p>-          Functional plasma jet systems working in suspensions of nanocellulose;</p> <p>-          Communications: PHB/modified NC composites; SLP systems;</p> <p>-          Report with scientific data on biomaterial characteristics before and after treatment.</p> <p><strong>Activities:</strong></p> <p><strong><em>Activity I.1</em></strong>Preparation of nanocellulose according to the procedures patented in the frame of the previous projects, and verification of thermal stability and nanodimension (NIRD for Chenistry and Petrocehmistry ICECHIM)</p> <p><strong><em>Activity I.2</em></strong>Plasma treatment of NC in water suspension by in contact and submerge techniques (NIRD for Laser, Plasma and Radiation Physics INFLPR)</p> <p><strong><em>Activity I.3</em></strong>Characterization of modified NC: composition, dimensions, surface modification (ICECHIM and INFLPR)</p> <p><strong><em>Activity I.4</em></strong> Preliminary conditions established for plasma treatment of NC suspensions in water (ICECHIM and INFLPR)</p> <p><strong><em>Activity I.5</em></strong> Surface modification of NC using plasma treatment in liquids mixture starting from the conditions established in the previous phase (INFLPR)</p> <p><strong><em>Activity I.6</em></strong> Characterization of different modified NC (ICECHIM and INFLPR)</p> <p><strong><em>Activity I.7</em></strong> PHB/modified NC (I) composites by solution casting or melt processing; characterization of composite materials (ICECHIM)</p> <p><strong><em>Activity I.8</em></strong> Surface functionalization of nanocellulose by plasma treatment in liquids using precursor; Characterization of modified NC (ICECHIM and INFLPR)</p> <p><strong><em>Activity I.9</em></strong> Preparation of PHB/modified NC (II) composites by solution casting or melt processing and characterization of composite materials (ICECHIM)</p> <p><strong><em>Activity I.10</em></strong> Dissemination of non-patentable results (ICECHIM and INFLPR)</p> <p><strong>Results: </strong></p> <p>-          Parameter values for plasma systems in liquid (established: power, flow range, treatment time, mixture of gases);</p> <p><strong>-          </strong>PHB composites with NC modified in various working conditions;</p> <p>-          Functional plasma jet systems working in suspensions of nanocellulose;</p> <p>-          Report with scientific data on biomaterial characteristics before and after treatment;</p> <p>-          Dissemination: 3 published papers with polymer - NC composites and SLP systems; 8 communications</p> </div> </div> </div> </div> </div> </div> </div> </section> </div>  <div class="footer"> <div class="container"> <div class="row"> <div class="span9"> <br /><br /><br /> </div></div> <p align=center><font color="#CCCCCC">  © ICECHIM - All Rights Reserved</font></p> <center><a href="https://icechim.ro">https://icechim.ro</a></center> <br /><br /><br /> </div> </div> </body> </html>