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class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Clinical_significance"> <div class="vector-toc-text"> <span class="vector-toc-numb">4</span> <span>Clinical significance</span> </div> </a> <button aria-controls="toc-Clinical_significance-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Clinical significance subsection</span> </button> <ul id="toc-Clinical_significance-sublist" class="vector-toc-list"> <li id="toc-Cancer" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Cancer"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.1</span> <span>Cancer</span> </div> </a> <ul id="toc-Cancer-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Mutations" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Mutations"> <div class="vector-toc-text"> <span class="vector-toc-numb">4.2</span> <span>Mutations</span> </div> </a> <ul id="toc-Mutations-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-As_a_drug_target" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#As_a_drug_target"> <div class="vector-toc-text"> <span class="vector-toc-numb">5</span> <span>As a drug target</span> </div> </a> <ul id="toc-As_a_drug_target-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Diagnostics" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Diagnostics"> <div class="vector-toc-text"> <span class="vector-toc-numb">6</span> <span>Diagnostics</span> </div> </a> <button aria-controls="toc-Diagnostics-sublist" class="cdx-button cdx-button--weight-quiet cdx-button--icon-only vector-toc-toggle"> <span class="vector-icon mw-ui-icon-wikimedia-expand"></span> <span>Toggle Diagnostics subsection</span> </button> <ul id="toc-Diagnostics-sublist" class="vector-toc-list"> <li id="toc-Immunohistochemistry" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Immunohistochemistry"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.1</span> <span>Immunohistochemistry</span> </div> </a> <ul id="toc-Immunohistochemistry-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Fluorescence_in_situ_hybridisation" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Fluorescence_in_situ_hybridisation"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.2</span> <span>Fluorescence <i>in situ</i> hybridisation</span> </div> </a> <ul id="toc-Fluorescence_in_situ_hybridisation-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Serum" class="vector-toc-list-item vector-toc-level-2"> <a class="vector-toc-link" href="#Serum"> <div class="vector-toc-text"> <span class="vector-toc-numb">6.3</span> <span>Serum</span> </div> </a> <ul id="toc-Serum-sublist" class="vector-toc-list"> </ul> </li> </ul> </li> <li id="toc-Interactions" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Interactions"> <div class="vector-toc-text"> <span class="vector-toc-numb">7</span> <span>Interactions</span> </div> </a> <ul id="toc-Interactions-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-See_also" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#See_also"> <div class="vector-toc-text"> <span class="vector-toc-numb">8</span> <span>See also</span> </div> </a> <ul id="toc-See_also-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-References" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#References"> <div class="vector-toc-text"> <span class="vector-toc-numb">9</span> <span>References</span> </div> </a> <ul id="toc-References-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-Further_reading" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#Further_reading"> <div class="vector-toc-text"> <span class="vector-toc-numb">10</span> <span>Further reading</span> </div> </a> <ul id="toc-Further_reading-sublist" class="vector-toc-list"> </ul> </li> <li id="toc-External_links" class="vector-toc-list-item vector-toc-level-1 vector-toc-list-item-expanded"> <a class="vector-toc-link" href="#External_links"> <div class="vector-toc-text"> <span class="vector-toc-numb">11</span> <span>External links</span> </div> </a> <ul id="toc-External_links-sublist" class="vector-toc-list"> </ul> </li> </ul> </div> </div> </nav> </div> </div> <div class="mw-content-container"> <main id="content" class="mw-body"> <header class="mw-body-header vector-page-titlebar"> <nav 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id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">HER2</span></h1> <div id="p-lang-btn" class="vector-dropdown mw-portlet mw-portlet-lang" > <input type="checkbox" id="p-lang-btn-checkbox" role="button" aria-haspopup="true" data-event-name="ui.dropdown-p-lang-btn" class="vector-dropdown-checkbox mw-interlanguage-selector" aria-label="Go to an article in another language. Available in 21 languages" > <label id="p-lang-btn-label" for="p-lang-btn-checkbox" class="vector-dropdown-label cdx-button cdx-button--fake-button cdx-button--fake-button--enabled cdx-button--weight-quiet cdx-button--action-progressive mw-portlet-lang-heading-21" aria-hidden="true" ><span class="vector-icon mw-ui-icon-language-progressive mw-ui-icon-wikimedia-language-progressive"></span> <span class="vector-dropdown-label-text">21 languages</span> </label> <div class="vector-dropdown-content"> <div class="vector-menu-content"> <ul class="vector-menu-content-list"> <li class="interlanguage-link interwiki-ar mw-list-item"><a href="https://ar.wikipedia.org/wiki/%D9%85%D8%B3%D8%AA%D9%82%D8%A8%D9%84_%D8%B9%D8%A7%D9%85%D9%84_%D9%86%D9%85%D9%88_%D8%A7%D9%84%D8%A8%D8%B4%D8%B1%D9%8A_%D8%A7%D9%84%D8%AB%D8%A7%D9%86%D9%8A" title="مستقبل عامل نمو البشري الثاني – Arabic" lang="ar" hreflang="ar" data-title="مستقبل عامل نمو البشري الثاني" data-language-autonym="العربية" data-language-local-name="Arabic" class="interlanguage-link-target"><span>العربية</span></a></li><li class="interlanguage-link interwiki-bs mw-list-item"><a href="https://bs.wikipedia.org/wiki/ERBB2" title="ERBB2 – Bosnian" lang="bs" hreflang="bs" data-title="ERBB2" data-language-autonym="Bosanski" data-language-local-name="Bosnian" class="interlanguage-link-target"><span>Bosanski</span></a></li><li class="interlanguage-link interwiki-cy mw-list-item"><a href="https://cy.wikipedia.org/wiki/ERBB2" title="ERBB2 – Welsh" lang="cy" hreflang="cy" data-title="ERBB2" data-language-autonym="Cymraeg" data-language-local-name="Welsh" class="interlanguage-link-target"><span>Cymraeg</span></a></li><li class="interlanguage-link interwiki-de mw-list-item"><a href="https://de.wikipedia.org/wiki/HER2/neu" title="HER2/neu – German" lang="de" hreflang="de" data-title="HER2/neu" data-language-autonym="Deutsch" data-language-local-name="German" class="interlanguage-link-target"><span>Deutsch</span></a></li><li class="interlanguage-link interwiki-es mw-list-item"><a href="https://es.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Spanish" lang="es" hreflang="es" data-title="HER2/neu" data-language-autonym="Español" data-language-local-name="Spanish" class="interlanguage-link-target"><span>Español</span></a></li><li class="interlanguage-link interwiki-fa mw-list-item"><a href="https://fa.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Persian" lang="fa" hreflang="fa" data-title="HER2/neu" data-language-autonym="فارسی" data-language-local-name="Persian" class="interlanguage-link-target"><span>فارسی</span></a></li><li class="interlanguage-link interwiki-fr mw-list-item"><a href="https://fr.wikipedia.org/wiki/HER2" title="HER2 – French" lang="fr" hreflang="fr" data-title="HER2" data-language-autonym="Français" data-language-local-name="French" class="interlanguage-link-target"><span>Français</span></a></li><li class="interlanguage-link interwiki-gl mw-list-item"><a href="https://gl.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Galician" lang="gl" hreflang="gl" data-title="HER2/neu" data-language-autonym="Galego" data-language-local-name="Galician" class="interlanguage-link-target"><span>Galego</span></a></li><li class="interlanguage-link interwiki-ko mw-list-item"><a href="https://ko.wikipedia.org/wiki/HER2" title="HER2 – Korean" lang="ko" hreflang="ko" data-title="HER2" data-language-autonym="한국어" data-language-local-name="Korean" class="interlanguage-link-target"><span>한국어</span></a></li><li class="interlanguage-link interwiki-it mw-list-item"><a href="https://it.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Italian" lang="it" hreflang="it" data-title="HER2/neu" data-language-autonym="Italiano" data-language-local-name="Italian" class="interlanguage-link-target"><span>Italiano</span></a></li><li class="interlanguage-link interwiki-he mw-list-item"><a href="https://he.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Hebrew" lang="he" hreflang="he" data-title="HER2/neu" data-language-autonym="עברית" data-language-local-name="Hebrew" class="interlanguage-link-target"><span>עברית</span></a></li><li class="interlanguage-link interwiki-nl mw-list-item"><a href="https://nl.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Dutch" lang="nl" hreflang="nl" data-title="HER2/neu" data-language-autonym="Nederlands" data-language-local-name="Dutch" class="interlanguage-link-target"><span>Nederlands</span></a></li><li class="interlanguage-link interwiki-ja mw-list-item"><a href="https://ja.wikipedia.org/wiki/HER2" title="HER2 – Japanese" lang="ja" hreflang="ja" data-title="HER2" data-language-autonym="日本語" data-language-local-name="Japanese" class="interlanguage-link-target"><span>日本語</span></a></li><li class="interlanguage-link interwiki-pt mw-list-item"><a href="https://pt.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Portuguese" lang="pt" hreflang="pt" data-title="HER2/neu" data-language-autonym="Português" data-language-local-name="Portuguese" class="interlanguage-link-target"><span>Português</span></a></li><li class="interlanguage-link interwiki-ru mw-list-item"><a href="https://ru.wikipedia.org/wiki/HER2" title="HER2 – Russian" lang="ru" hreflang="ru" data-title="HER2" data-language-autonym="Русский" data-language-local-name="Russian" class="interlanguage-link-target"><span>Русский</span></a></li><li class="interlanguage-link interwiki-sl mw-list-item"><a href="https://sl.wikipedia.org/wiki/Receptor_2_za_epidermalni_rastni_faktor" title="Receptor 2 za epidermalni rastni faktor – Slovenian" lang="sl" hreflang="sl" data-title="Receptor 2 za epidermalni rastni faktor" data-language-autonym="Slovenščina" data-language-local-name="Slovenian" class="interlanguage-link-target"><span>Slovenščina</span></a></li><li class="interlanguage-link interwiki-sr mw-list-item"><a href="https://sr.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Serbian" lang="sr" hreflang="sr" data-title="HER2/neu" data-language-autonym="Српски / srpski" data-language-local-name="Serbian" class="interlanguage-link-target"><span>Српски / srpski</span></a></li><li class="interlanguage-link interwiki-sh mw-list-item"><a href="https://sh.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Serbo-Croatian" lang="sh" hreflang="sh" data-title="HER2/neu" data-language-autonym="Srpskohrvatski / српскохрватски" data-language-local-name="Serbo-Croatian" class="interlanguage-link-target"><span>Srpskohrvatski / српскохрватски</span></a></li><li class="interlanguage-link interwiki-uk mw-list-item"><a href="https://uk.wikipedia.org/wiki/ERBB2" title="ERBB2 – Ukrainian" lang="uk" hreflang="uk" data-title="ERBB2" data-language-autonym="Українська" data-language-local-name="Ukrainian" class="interlanguage-link-target"><span>Українська</span></a></li><li class="interlanguage-link interwiki-vi mw-list-item"><a href="https://vi.wikipedia.org/wiki/HER-2/neu" title="HER-2/neu – Vietnamese" lang="vi" hreflang="vi" data-title="HER-2/neu" data-language-autonym="Tiếng Việt" data-language-local-name="Vietnamese" class="interlanguage-link-target"><span>Tiếng Việt</span></a></li><li class="interlanguage-link interwiki-zh mw-list-item"><a href="https://zh.wikipedia.org/wiki/HER2/neu" title="HER2/neu – Chinese" lang="zh" hreflang="zh" data-title="HER2/neu" data-language-autonym="中文" data-language-local-name="Chinese" class="interlanguage-link-target"><span>中文</span></a></li> </ul> <div class="after-portlet after-portlet-lang"><span class="wb-langlinks-edit wb-langlinks-link"><a href="https://www.wikidata.org/wiki/Special:EntityPage/Q415271#sitelinks-wikipedia" title="Edit interlanguage links" class="wbc-editpage">Edit links</a></span></div> </div> </div> </div> </header> <div class="vector-page-toolbar"> <div class="vector-page-toolbar-container"> <div id="left-navigation"> <nav aria-label="Namespaces"> 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class="vector-body" aria-labelledby="firstHeading" data-mw-ve-target-container> <div class="vector-body-before-content"> <div class="mw-indicators"> </div> <div id="siteSub" class="noprint">From Wikipedia, the free encyclopedia</div> </div> <div id="contentSub"><div id="mw-content-subtitle"></div></div> <div id="mw-content-text" class="mw-body-content"><div class="mw-content-ltr mw-parser-output" lang="en" dir="ltr"><div class="shortdescription nomobile noexcerpt noprint searchaux" style="display:none">Mammalian protein found in humans</div> <p class="mw-empty-elt"> </p> <table class="infobox" style="width:26.4em"><tbody><tr><th colspan="4" style="text-align:center;font-size:125%;font-weight:bold">ERBB2</th></tr><tr><td colspan="4" style="text-align:center"><span typeof="mw:File"><a href="/wiki/File:Trastuzumab_Fab-HER2_complex_1N8Z.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Trastuzumab_Fab-HER2_complex_1N8Z.png/250px-Trastuzumab_Fab-HER2_complex_1N8Z.png" decoding="async" width="250" height="238" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/15/Trastuzumab_Fab-HER2_complex_1N8Z.png/500px-Trastuzumab_Fab-HER2_complex_1N8Z.png 1.5x" data-file-width="1920" data-file-height="1824" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Available structures</th></tr><tr><th rowspan="2" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;width:43px"><a href="/wiki/Protein_Data_Bank" title="Protein Data Bank">PDB</a></th><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit">Ortholog search: <span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/searchResults.html?display=both&term=P70424%20or%20P04626">PDBe</a> <a rel="nofollow" class="external text" href="https://www.rcsb.org/search?q=rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_name:UniProt%20AND%20rcsb_polymer_entity_container_identifiers.reference_sequence_identifiers.database_accession:P70424,P04626">RCSB</a> </span></td></tr><tr><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr style="text-align:center"><th colspan="2" style="background-color:light-dark(#ddd, #404244) !important;color:inherit">List of PDB id codes</th></tr><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1MFG">1MFG</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1MFL">1MFL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1MW4">1MW4</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1N8Z">1N8Z</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1QR1">1QR1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/1S78">1S78</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2A91">2A91</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2JWA">2JWA</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2KS1">2KS1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2L4K">2L4K</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3BE1">3BE1</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3H3B">3H3B</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3N85">3N85</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3PP0">3PP0</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3RCD">3RCD</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3MZW">3MZW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3WLW">3WLW</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/3WSQ">3WSQ</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4GFU">4GFU</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HRL">4HRL</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HRM">4HRM</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/4HRN">4HRN</a>, <a rel="nofollow" class="external text" href="https://www.rcsb.org/structure/2N2A">2N2A</a></span></p></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Identifiers</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Gene_nomenclature" title="Gene nomenclature">Aliases</a></span></th><td colspan="3" style="background:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/3430">ERBB2</a></span>, CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2</td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">External IDs</th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Mendelian_Inheritance_in_Man" class="mw-redirect" title="Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://omim.org/entry/164870">164870</a>; <a href="/wiki/Mouse_Genome_Informatics" title="Mouse Genome Informatics">MGI</a>: <a rel="nofollow" class="external text" href="http://www.informatics.jax.org/marker/MGI:95410">95410</a>; <a href="/wiki/HomoloGene" title="HomoloGene">HomoloGene</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=homologene&dopt=HomoloGene&list_uids=3273">3273</a>; <a href="/wiki/GeneCards" title="GeneCards">GeneCards</a>: <a rel="nofollow" class="external text" href="https://www.genecards.org/cgi-bin/carddisp.pl?gene=ERBB2">ERBB2</a>; <a href="/wiki/Orthologous_MAtrix" title="Orthologous MAtrix">OMA</a>:<a rel="nofollow" class="external text" href="https://omabrowser.org/oma/vps/ENSG00000141736">ERBB2 - orthologs</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></th><td colspan="3" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.genome.jp/dbget-bin/www_bget?enzyme+2.7.10.1">2.7.10.1</a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Human_genome" title="Human genome">Human</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_human_chromosome_17.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/330px-Ideogram_human_chromosome_17.svg.png" decoding="async" width="300" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/450px-Ideogram_human_chromosome_17.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/0/00/Ideogram_human_chromosome_17.svg/600px-Ideogram_human_chromosome_17.svg.png 2x" data-file-width="474" data-file-height="189" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a href="/wiki/Chromosome_17_(human)" class="mw-redirect" title="Chromosome 17 (human)">Chromosome 17 (human)</a><sup id="cite_ref-refGRCh38Ensembl_1-0" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Human_chromosome_17_ideogram.svg" class="mw-file-description" title="Chromosome 17 (human)"><img alt="Chromosome 17 (human)" src="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/300px-Human_chromosome_17_ideogram.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/450px-Human_chromosome_17_ideogram.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/c/c7/Human_chromosome_17_ideogram.svg/600px-Human_chromosome_17_ideogram.svg.png 2x" data-file-width="1125" data-file-height="216" /></a></span><div style="position: absolute; left: 134.88518173462px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ERBB2"><img alt="Genomic location for ERBB2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 140.9px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ERBB2"><img alt="Genomic location for ERBB2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">17q12</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">39,687,914 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-1" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">39,730,426 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCh38Ensembl_1-2" class="reference"><a href="#cite_note-refGRCh38Ensembl-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit">Gene location (<a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a>)</th></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:Ideogram_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/330px-Ideogram_house_mouse_chromosome_11.svg.png" decoding="async" width="260" height="111" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/390px-Ideogram_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/a/a5/Ideogram_house_mouse_chromosome_11.svg/520px-Ideogram_house_mouse_chromosome_11.svg.png 2x" data-file-width="470" data-file-height="200" /></a></span></td></tr><tr><th scope="row" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Chromosome" title="Chromosome">Chr.</a></th><td colspan="3" width="85%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">Chromosome 11 (mouse)<sup id="cite_ref-refGRCm38Ensembl_2-0" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><div align="center"><div style="position: relative; width: 300px;"><span typeof="mw:File"><a href="/wiki/File:Ideogram_of_house_mouse_chromosome_11.svg" class="mw-file-description" title="Chromosome 11 (mouse)"><img alt="Chromosome 11 (mouse)" src="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/300px-Ideogram_of_house_mouse_chromosome_11.svg.png" decoding="async" width="300" height="58" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/450px-Ideogram_of_house_mouse_chromosome_11.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/2/2a/Ideogram_of_house_mouse_chromosome_11.svg/600px-Ideogram_of_house_mouse_chromosome_11.svg.png 2x" data-file-width="1200" data-file-height="231" /></a></span><div style="position: absolute; left: 231.47232552496px; top: 2px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:HSR_1996_II_3.5e.svg" class="mw-file-description" title="Genomic location for ERBB2"><img alt="Genomic location for ERBB2" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/14px-HSR_1996_II_3.5e.svg.png" decoding="async" width="14" height="14" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/21px-HSR_1996_II_3.5e.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d8/HSR_1996_II_3.5e.svg/28px-HSR_1996_II_3.5e.svg.png 2x" data-file-width="142" data-file-height="142" /></a></span></div><div style="position: absolute; left: 237.5px; top: 19px; padding: 0;"><span typeof="mw:File"><a href="/wiki/File:Red_rectangle_2x18.png" class="mw-file-description" title="Genomic location for ERBB2"><img alt="Genomic location for ERBB2" src="//upload.wikimedia.org/wikipedia/commons/6/6a/Red_rectangle_2x18.png" decoding="async" width="2" height="18" class="mw-file-element" data-file-width="2" data-file-height="18" /></a></span></div></div></div></td></tr><tr><th scope="row" rowspan="2" width="15%" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Locus_(genetics)" title="Locus (genetics)">Band</a></th><td rowspan="2" width="35%" style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">11 61.75 cM|11 D</span></td><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Start</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">98,303,296 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-1" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">End</th><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks">98,328,542 <a href="/wiki/Base_pair" title="Base pair">bp</a><sup id="cite_ref-refGRCm38Ensembl_2-2" class="reference"><a href="#cite_note-refGRCm38Ensembl-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_expression" title="Gene expression">RNA expression</a> pattern</th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="https://www.bgee.org/">Bgee</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th><b><a href="/wiki/Human_genome" title="Human genome">Human</a></b></th><th><b><a href="/wiki/Laboratory_mouse" title="Laboratory mouse">Mouse</a> (ortholog)</b></th></tr><tr><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000141736">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">right uterine tube</li><br /><li style="line-height: 137%;">sural nerve</li><br /><li style="line-height: 137%;">skin of leg</li><br /><li style="line-height: 137%;">skin of abdomen</li><br /><li style="line-height: 137%;">renal medulla</li><br /><li style="line-height: 137%;">minor salivary glands</li><br /><li style="line-height: 137%;">right lobe of thyroid gland</li><br /><li style="line-height: 137%;">olfactory zone of nasal mucosa</li><br /><li style="line-height: 137%;">mucosa of transverse colon</li><br /><li style="line-height: 137%;">left lobe of thyroid gland</li></ul></div></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="1"><span class="plainlinks" style="margin:-3px"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSMUSG00000062312">Top expressed in</a></span></td></tr><tr><td colspan="1"><div class="plainlinks" style="margin:-12px 0px -10px 0px"><ul style="line-height:15%;margin:9px"><li style="line-height: 137%;">lip</li><br /><li style="line-height: 137%;">intestinal villus</li><br /><li style="line-height: 137%;">middle ear</li><br /><li style="line-height: 137%;">Eustachian tube</li><br /><li style="line-height: 137%;">oral mucosa</li><br /><li style="line-height: 137%;">esophagus</li><br /><li style="line-height: 137%;">colon</li><br /><li style="line-height: 137%;">crypt of lieberkuhn of small intestine</li><br /><li style="line-height: 137%;">right kidney</li><br /><li style="line-height: 137%;">left colon</li></ul></div></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.bgee.org/gene/ENSG00000141736">More reference expression data</a></span></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a rel="nofollow" class="external text" href="http://biogps.org/">BioGPS</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ERBB2_210930_s_at.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/7/72/PBB_GE_ERBB2_210930_s_at.png/250px-PBB_GE_ERBB2_210930_s_at.png" decoding="async" width="250" height="132" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/7/72/PBB_GE_ERBB2_210930_s_at.png 1.5x" data-file-width="255" data-file-height="135" /></a></span><br /><br /><span typeof="mw:File"><a href="/wiki/File:PBB_GE_ERBB2_216836_s_at.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8d/PBB_GE_ERBB2_216836_s_at.png/250px-PBB_GE_ERBB2_216836_s_at.png" decoding="async" width="250" height="132" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/8/8d/PBB_GE_ERBB2_216836_s_at.png 1.5x" data-file-width="255" data-file-height="135" /></a></span></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><span class="plainlinks"><a rel="nofollow" class="external text" href="http://biogps.org/gene/2064/">More reference expression data</a></span></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Gene_ontology" class="mw-redirect" title="Gene ontology">Gene ontology</a></th></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Molecular function</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043125">ErbB-3 class receptor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016740">transferase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000166">nucleotide binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004672">protein kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046983">protein dimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019838">growth factor binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001042">RNA polymerase I core binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016301">kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008022">protein C-terminus binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005515">protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042802">identical protein binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046982">protein heterodimerization activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004714">transmembrane receptor protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004713">protein tyrosine kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0019903">protein phosphatase binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005524">ATP binding</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0004888">transmembrane signaling receptor activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046934">phosphatidylinositol-4,5-bisphosphate 3-kinase activity</a></li> <li><a href="https://www.wikidata.org/wiki/Q420511" class="extiw" title="d:Q420511">receptor tyrosine kinase</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Cellular component</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016021">integral component of membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016020">membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043209">myelin sheath</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043235">receptor complex</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005886">plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016323">basolateral plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016324">apical plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048471">perinuclear region of cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010008">endosome membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0031410">cytoplasmic vesicle</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005634">nucleus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005737">cytoplasm</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005829">cytosol</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0005887">integral component of plasma membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009925">basal plasma membrane</a></li></ul> </div></td></tr><tr><td style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit;font-weight:bold">Biological process</td><td style="background-color:light-dark(#eee, #27292d) !important;color:inherit"><div class="plainlinks"> <ul><li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0001934">positive regulation of protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007422">peripheral nervous system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006355">regulation of transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0033088">negative regulation of immature T cell proliferation in thymus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043406">positive regulation of MAP kinase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0016310">phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007169">transmembrane receptor protein tyrosine kinase signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0050679">positive regulation of epithelial cell proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071363">cellular response to growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042060">wound healing</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0048709">oligodendrocyte differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045765">regulation of angiogenesis</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045727">positive regulation of translation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006351">transcription, DNA-templated</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007399">nervous system development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0000165">MAPK cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006468">protein phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007507">heart development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007166">cell surface receptor signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043547">positive regulation of GTPase activity</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030307">positive regulation of cell growth</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0032886">regulation of microtubule-based process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007528">neuromuscular junction development</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070372">regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0042552">myelination</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046777">protein autophosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0014065">phosphatidylinositol 3-kinase signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045943">positive regulation of transcription by RNA polymerase I</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008283">cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045945">positive regulation of transcription by RNA polymerase III</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008045">motor neuron axon guidance</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007167">enzyme linked receptor protein signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0007165">signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0045785">positive regulation of cell adhesion</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0090314">positive regulation of protein targeting to membrane</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0038128">ERBB2 signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0046854">phosphatidylinositol phosphate biosynthetic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0010628">positive regulation of gene expression</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0018108">peptidyl-tyrosine phosphorylation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:2000145">regulation of cell motility</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0071364">cellular response to epidermal growth factor stimulus</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0006357">regulation of transcription by RNA polymerase II</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:1901185">negative regulation of ERBB signaling pathway</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0051897">positive regulation of protein kinase B signaling</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0009968">negative regulation of signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030154">cell differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043066">negative regulation of apoptotic process</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0070374">positive regulation of ERK1 and ERK2 cascade</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0035556">intracellular signal transduction</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0008284">positive regulation of cell population proliferation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0030182">neuron differentiation</a></li> <li><a rel="nofollow" class="external text" href="http://amigo.geneontology.org/amigo/term/GO:0043410">positive regulation of MAPK cascade</a></li></ul> </div></td></tr><tr><td colspan="4" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center">Sources:<a rel="nofollow" class="external text" href="http://amigo.geneontology.org/">Amigo</a> / <a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/QuickGO/">QuickGO</a></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table class="collapsible" style="padding:0;border:none;margin:0;width:100%;text-align:left"><tbody><tr><th colspan="4" style="text-align:center;background-color:light-dark(#ddd, #404244) !important;color:inherit"><a href="/wiki/Orthologs" class="mw-redirect" title="Orthologs">Orthologs</a></th></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Species</th><td><b>Human</b></td><td><b>Mouse</b></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Entrez" title="Entrez">Entrez</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=2064&rn=1">2064</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&cmd=retrieve&dopt=default&list_uids=13866&rn=1">13866</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/Ensembl" class="mw-redirect" title="Ensembl">Ensembl</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Homo_sapiens/geneview?gene=ENSG00000141736;db=core">ENSG00000141736</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="http://www.ensembl.org/Mus_musculus/geneview?gene=ENSMUSG00000062312;db=core">ENSMUSG00000062312</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/UniProt" title="UniProt">UniProt</a></th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P04626">P04626</a></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1"><span class="plainlinks"></span></th></tr><tr><td colspan="1"><p class="plainlinks"><a rel="nofollow" class="external text" href="https://www.uniprot.org/uniprot/P70424">P70424</a></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (mRNA)</th><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001005862">NM_001005862</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289936">NM_001289936</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289937">NM_001289937</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001289938">NM_001289938</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_004448">NM_004448</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_001003817">NM_001003817</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NM_010152">NM_010152</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">RefSeq (protein)</th><td><table class="collapsible collapsed" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001005862">NP_001005862</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276865">NP_001276865</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276866">NP_001276866</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001276867">NP_001276867</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_004439">NP_004439</a><br /></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369711">NP_001369711</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369712">NP_001369712</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369713">NP_001369713</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369714">NP_001369714</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369715">NP_001369715</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369716">NP_001369716</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369717">NP_001369717</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369718">NP_001369718</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369719">NP_001369719</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369720">NP_001369720</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369721">NP_001369721</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369722">NP_001369722</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369723">NP_001369723</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369724">NP_001369724</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369725">NP_001369725</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369726">NP_001369726</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369727">NP_001369727</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369728">NP_001369728</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369729">NP_001369729</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369730">NP_001369730</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369731">NP_001369731</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369732">NP_001369732</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369733">NP_001369733</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369734">NP_001369734</a><br /><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001369735">NP_001369735</a></span></p></td></tr></tbody></table></td><td><table class="none" style="padding:0;border:none;margin:0;width:100%;text-align:right"><tbody><tr><th colspan="1" class="plainlinks"></th></tr><tr><td colspan="1"><p><span class="plainlinks"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=NP_001003817">NP_001003817</a></span></p></td></tr></tbody></table></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit">Location (UCSC)</th><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Human&db=hg38&position=chr17:39687914-39730426">Chr 17: 39.69 – 39.73 Mb</a></span></td><td><span class="plainlinks"><a rel="nofollow" class="external text" href="https://genome.ucsc.edu/cgi-bin/hgTracks?org=Mouse&db=mm0&position=chr11:98303296-98328542">Chr 11: 98.3 – 98.33 Mb</a></span></td></tr><tr><th scope="row" style="background-color:light-dark(#c3fdb8, #003500) !important;color:inherit"><a href="/wiki/PubMed" title="PubMed">PubMed</a> search</th><td><span class="plainlinks"><sup id="cite_ref-3" class="reference"><a href="#cite_note-3"><span class="cite-bracket">[</span>3<span class="cite-bracket">]</span></a></sup></span></td><td><span class="plainlinks"><sup id="cite_ref-4" class="reference"><a href="#cite_note-4"><span class="cite-bracket">[</span>4<span class="cite-bracket">]</span></a></sup></span></td></tr></tbody></table></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><a href="/wiki/Wikidata" title="Wikidata">Wikidata</a></td></tr><tr><td colspan="4" style="text-align:center;background-color:light-dark(#eee, #27292d) !important;color:inherit"><table style="padding:0;border:none;margin:0;width:100%;text-align:center"><tbody><tr><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14877486" class="extiw" title="d:Q14877486">View/Edit Human</a></td><td colspan="2" style="background-color:light-dark(#eee, #27292d) !important;color:inherit;text-align:center"><a href="https://www.wikidata.org/wiki/Q14877488" class="extiw" title="d:Q14877488">View/Edit Mouse</a></td></tr></tbody></table></td></tr></tbody></table> <p><b>Receptor tyrosine-protein kinase erbB-2</b> is a <a href="/wiki/Protein" title="Protein">protein</a> that normally resides in the membranes of cells and is encoded by the <i><b>ERBB2</b></i> <a href="/wiki/Gene" title="Gene">gene</a>. ERBB is abbreviated from erythroblastic oncogene B, a gene originally isolated from the avian genome. The human protein is also frequently referred to as <b>HER2</b> (human epidermal growth factor receptor 2) or <b>CD340</b> (<a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">cluster of differentiation</a> 340).<sup id="cite_ref-5" class="reference"><a href="#cite_note-5"><span class="cite-bracket">[</span>5<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-6" class="reference"><a href="#cite_note-6"><span class="cite-bracket">[</span>6<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-7" class="reference"><a href="#cite_note-7"><span class="cite-bracket">[</span>7<span class="cite-bracket">]</span></a></sup> </p><p>HER2 is a member of the human <a href="/wiki/EGFR_family" class="mw-redirect" title="EGFR family">epidermal growth factor receptor (HER/EGFR/ERBB) family</a>. But contrary to other members of the ERBB family, HER2 does not directly bind ligand. HER2 activation results from heterodimerization with another ERBB member or by homodimerization when HER2 concentration are high, for instance in cancer.<sup id="cite_ref-8" class="reference"><a href="#cite_note-8"><span class="cite-bracket">[</span>8<span class="cite-bracket">]</span></a></sup> <a href="/wiki/Gene_duplication" title="Gene duplication">Amplification</a> or over-expression of this <a href="/wiki/Oncogene" title="Oncogene">oncogene</a> has been shown to play an important role in the development and progression of certain aggressive types of <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a>. In recent years the protein has become an important <a href="/wiki/Biomarker_(medicine)" title="Biomarker (medicine)">biomarker</a> and target of therapy for approximately 30% of <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a> patients.<sup id="cite_ref-pmid23320171_9-0" class="reference"><a href="#cite_note-pmid23320171-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup> </p> <meta property="mw:PageProp/toc" /> <div class="mw-heading mw-heading2"><h2 id="Name">Name</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=1" title="Edit section: Name"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>HER2</i> is named as such due to structural similarities with human epidermal growth factor receptor 1, or <a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">HER1</a><i>.</i> </p><p>The <i>Neu</i> alias of HER2 derives its name from the parent <a href="/wiki/Glioblastoma" title="Glioblastoma">glioblastoma</a> cell line - a type of <i>neural</i> tumor found in rodents. </p><p><i>ErbB-2</i> was named for its similarity to avian erythroblastosis oncogene B<i>, ErbB</i>; the <a href="/wiki/Oncogene" title="Oncogene">oncogene</a> later shown to code for epidermal growth factor receptor, <a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGFR</a>. </p><p>Molecular cloning of EGFR discovered that HER2, Neu, and ErbB-2 are all encoded by the same <a href="/wiki/Orthologous_gene" class="mw-redirect" title="Orthologous gene">orthologs</a>.<sup id="cite_ref-Coussens_1985_10-0" class="reference"><a href="#cite_note-Coussens_1985-10"><span class="cite-bracket">[</span>10<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Gene">Gene</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=2" title="Edit section: Gene"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p><i>ERBB2</i>, a known <a href="/wiki/Proto-oncogene" class="mw-redirect" title="Proto-oncogene">proto-oncogene</a>,<sup id="cite_ref-11" class="reference"><a href="#cite_note-11"><span class="cite-bracket">[</span>11<span class="cite-bracket">]</span></a></sup> is located at the long arm of human <a href="/wiki/Chromosome_17" title="Chromosome 17">chromosome 17</a> (17q12).<sup id="cite_ref-12" class="reference"><a href="#cite_note-12"><span class="cite-bracket">[</span>12<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Function">Function</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=3" title="Edit section: Function"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The <a href="/wiki/ErbB" title="ErbB">ErbB family</a> consists of four individual <a href="/wiki/Cell_membrane" title="Cell membrane">plasma membrane</a>-bound <a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">receptor tyrosine kinases</a>. One of which is erbB-2, and the other members being <a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">erbB-1</a>, <a href="/wiki/ERBB3" title="ERBB3">erbB-3</a> (neuregulin-binding; lacks kinase domain), and <a href="/wiki/ERBB4" title="ERBB4">erbB-4</a>. All four contain an extracellular ligand binding domain, a transmembrane domain, and an intracellular domain that can interact with a multitude of signaling molecules and exhibit both ligand-dependent and ligand-independent activity. Notably, no ligands for HER2 have yet been identified.<sup id="cite_ref-13" class="reference"><a href="#cite_note-13"><span class="cite-bracket">[</span>13<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-14" class="reference"><a href="#cite_note-14"><span class="cite-bracket">[</span>14<span class="cite-bracket">]</span></a></sup> HER2 can heterodimerise with any of the other three receptors and is considered to be the preferred dimerisation partner of the other ErbB receptors.<sup id="cite_ref-Olayioye_2001_15-0" class="reference"><a href="#cite_note-Olayioye_2001-15"><span class="cite-bracket">[</span>15<span class="cite-bracket">]</span></a></sup> </p><p>Dimerisation results in the <a href="/wiki/Autophosphorylation" title="Autophosphorylation">autophosphorylation</a> of tyrosine residues within the cytoplasmic domain of the receptors and initiates a variety of signaling pathways. </p> <div class="mw-heading mw-heading3"><h3 id="Signal_transduction">Signal transduction</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=4" title="Edit section: Signal transduction"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Signaling pathways activated by HER2 include:<sup id="cite_ref-pmid19887469_16-0" class="reference"><a href="#cite_note-pmid19887469-16"><span class="cite-bracket">[</span>16<span class="cite-bracket">]</span></a></sup> </p> <ul><li><a href="/wiki/Mitogen-activated_protein_kinase" title="Mitogen-activated protein kinase">mitogen-activated protein kinase</a> (MAPK)</li> <li><a href="/wiki/Phosphoinositide_3-kinase" title="Phosphoinositide 3-kinase">phosphoinositide 3-kinase</a> (PI3K/Akt)</li> <li><a href="/wiki/Phospholipase_C" title="Phospholipase C">phospholipase C</a> γ</li> <li><a href="/wiki/Protein_kinase_C" title="Protein kinase C">protein kinase C</a> (PKC)</li> <li><a href="/wiki/STAT_protein" title="STAT protein">Signal transducer and activator of transcription</a> (STAT)</li></ul> <p>In summary, signaling through the ErbB family of receptors promotes cell proliferation and opposes <a href="/wiki/Apoptosis" title="Apoptosis">apoptosis</a>, and therefore must be tightly regulated to prevent uncontrolled cell growth from occurring. </p> <div class="mw-heading mw-heading2"><h2 id="Clinical_significance">Clinical significance</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=5" title="Edit section: Clinical significance"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <div class="mw-heading mw-heading3"><h3 id="Cancer">Cancer</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=6" title="Edit section: Cancer"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Amplification, also known as the over-expression of the <i>ERBB2</i> gene, occurs in approximately 15-30% of <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancers</a>.<sup id="cite_ref-pmid23320171_9-1" class="reference"><a href="#cite_note-pmid23320171-9"><span class="cite-bracket">[</span>9<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid16236735_17-0" class="reference"><a href="#cite_note-pmid16236735-17"><span class="cite-bracket">[</span>17<span class="cite-bracket">]</span></a></sup> HER2-positive breast cancers are well established as being associated with increased disease recurrence and a poor prognosis compared with other identifiably genetically distinct breast cancers with other known, or lack thereof, genetic markers that are thought to be associated with other breast cancers; however, drug agents targeting HER2 in breast cancer have significantly and positively altered the otherwise poor prognosis of the historically problematic difficulties associated with HER2-positive breast cancer.<sup id="cite_ref-pmid17993237_18-0" class="reference"><a href="#cite_note-pmid17993237-18"><span class="cite-bracket">[</span>18<span class="cite-bracket">]</span></a></sup> Over-expression is also known to occur in ovarian,<sup id="cite_ref-19" class="reference"><a href="#cite_note-19"><span class="cite-bracket">[</span>19<span class="cite-bracket">]</span></a></sup> stomach, <a href="/wiki/Adenocarcinoma_of_the_lung" title="Adenocarcinoma of the lung">adenocarcinoma of the lung</a><sup id="cite_ref-20" class="reference"><a href="#cite_note-20"><span class="cite-bracket">[</span>20<span class="cite-bracket">]</span></a></sup> and aggressive forms of uterine cancer, such as uterine serous <a href="/wiki/Endometrial_carcinoma" class="mw-redirect" title="Endometrial carcinoma">endometrial carcinoma</a>,<sup id="cite_ref-21" class="reference"><a href="#cite_note-21"><span class="cite-bracket">[</span>21<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Buza2014_22-0" class="reference"><a href="#cite_note-Buza2014-22"><span class="cite-bracket">[</span>22<span class="cite-bracket">]</span></a></sup> e.g. HER2 is over-expressed in approximately 7-34% of patients with gastric cancer<sup id="cite_ref-Rüschoff2012_23-0" class="reference"><a href="#cite_note-Rüschoff2012-23"><span class="cite-bracket">[</span>23<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid21556317_24-0" class="reference"><a href="#cite_note-pmid21556317-24"><span class="cite-bracket">[</span>24<span class="cite-bracket">]</span></a></sup> and in 30% of salivary duct carcinomas.<sup id="cite_ref-25" class="reference"><a href="#cite_note-25"><span class="cite-bracket">[</span>25<span class="cite-bracket">]</span></a></sup> </p><p>HER2 is colocalised and most of the time, coamplified with the gene <a href="/wiki/GRB7" title="GRB7">GRB7</a>, which is a proto-oncogene associated with breast, testicular germ cell, gastric, and esophageal tumours. </p><p>HER2 proteins have been shown to form clusters in cell membranes that may play a role in tumorigenesis.<sup id="cite_ref-pmid10318765_26-0" class="reference"><a href="#cite_note-pmid10318765-26"><span class="cite-bracket">[</span>26<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid21118230_27-0" class="reference"><a href="#cite_note-pmid21118230-27"><span class="cite-bracket">[</span>27<span class="cite-bracket">]</span></a></sup> </p><p>Evidence has also implicated HER2 signaling in resistance to the <a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGFR</a>-targeted cancer drug <a href="/wiki/Cetuximab" title="Cetuximab">cetuximab</a>.<sup id="cite_ref-YonesakaZejnullahu2011_28-0" class="reference"><a href="#cite_note-YonesakaZejnullahu2011-28"><span class="cite-bracket">[</span>28<span class="cite-bracket">]</span></a></sup> </p><p>The high expression of HER2 correlates with better survival in esophageal adenocarcinoma.<sup id="cite_ref-29" class="reference"><a href="#cite_note-29"><span class="cite-bracket">[</span>29<span class="cite-bracket">]</span></a></sup> </p><p>The high amplification of HER2 copy number positively contributes to the survival time of gastric cardia adenocarcinoma patients.<sup id="cite_ref-30" class="reference"><a href="#cite_note-30"><span class="cite-bracket">[</span>30<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Mutations">Mutations</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=7" title="Edit section: Mutations"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>Furthermore, diverse structural alterations have been identified that cause ligand-independent firing of this receptor, doing so in the absence of receptor over-expression. HER2 is found in a variety of tumours and some of these tumours carry point mutations in the sequence specifying the transmembrane domain of HER2. Substitution of a valine for a glutamic acid or a glutamine in the transmembrane domain can result in the constitutive dimerisation of this protein in the absence of a ligand.<sup id="cite_ref-31" class="reference"><a href="#cite_note-31"><span class="cite-bracket">[</span>31<span class="cite-bracket">]</span></a></sup> </p><p>HER2 mutations have been found in <a href="/wiki/Non-small-cell_lung_cancer" title="Non-small-cell lung cancer">non-small-cell lung cancers</a> (NSCLC) and can direct treatment.<sup id="cite_ref-Mazières2013_32-0" class="reference"><a href="#cite_note-Mazières2013-32"><span class="cite-bracket">[</span>32<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="As_a_drug_target">As a drug target</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=8" title="Edit section: As a drug target"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HER2 is the target of the <a href="/wiki/Monoclonal_antibodies" class="mw-redirect" title="Monoclonal antibodies">monoclonal antibody</a> <a href="/wiki/Trastuzumab" title="Trastuzumab">trastuzumab</a> (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy.<sup id="cite_ref-pmid25848335_33-0" class="reference"><a href="#cite_note-pmid25848335-33"><span class="cite-bracket">[</span>33<span class="cite-bracket">]</span></a></sup> Twelve months of trastuzumab therapy is optimal. Randomized trials have demonstrated no additional benefit beyond 12 months, whereas 6 months has been shown to be inferior to 12. Trastuzumab is administered intravenously weekly or every 3 weeks.<sup id="cite_ref-34" class="reference"><a href="#cite_note-34"><span class="cite-bracket">[</span>34<span class="cite-bracket">]</span></a></sup> </p><p>An important downstream effect of trastuzumab binding to HER2 is an increase in <a href="/wiki/CDKN1B" title="CDKN1B">p27</a>, a protein that halts cell proliferation.<sup id="cite_ref-Le_2005_35-0" class="reference"><a href="#cite_note-Le_2005-35"><span class="cite-bracket">[</span>35<span class="cite-bracket">]</span></a></sup> Another monoclonal antibody, <a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a>, which inhibits dimerisation of HER2 and HER3 receptors, was approved by the FDA for use in combination with trastuzumab in June 2012. </p><p>As of November 2015, there are a number of ongoing and recently completed clinical trials of novel targeted agents for HER2+ metastatic breast cancer, e.g. <a href="/wiki/Margetuximab" title="Margetuximab">margetuximab</a>.<sup id="cite_ref-36" class="reference"><a href="#cite_note-36"><span class="cite-bracket">[</span>36<span class="cite-bracket">]</span></a></sup> </p><p>Additionally, <a href="/wiki/NeuVax" title="NeuVax">NeuVax</a> (<a href="/wiki/Galena_Biopharma" title="Galena Biopharma">Galena Biopharma</a>) is a peptide-based immunotherapy that directs "killer" <a href="/wiki/T_cell" title="T cell">T cells</a> to target and destroy cancer cells that express HER2. It has entered phase 3 clinical trials. </p><p>It has been found that patients with ER+ (<a href="/wiki/Estrogen_receptor" title="Estrogen receptor">Estrogen receptor</a> positive)/HER2+ compared with ER-/HER2+ breast cancers may actually benefit more from drugs that inhibit the <a href="/wiki/PI3K/AKT/mTOR_pathway" title="PI3K/AKT/mTOR pathway">PI3K/AKT</a> molecular pathway.<sup id="cite_ref-pmid19552798_37-0" class="reference"><a href="#cite_note-pmid19552798-37"><span class="cite-bracket">[</span>37<span class="cite-bracket">]</span></a></sup> </p><p>Over-expression of HER2 can also be suppressed by the amplification of other genes. Research is currently being conducted to discover which genes may have this desired effect. </p><p>The expression of HER2 is regulated by signaling through estrogen receptors. Normally, <a href="/wiki/Estradiol" title="Estradiol">estradiol</a> and <a href="/wiki/Tamoxifen" title="Tamoxifen">tamoxifen</a> acting through the estrogen receptor down-regulate the expression of HER2. However, when the ratio of the <a href="/wiki/Coactivator_(genetics)" title="Coactivator (genetics)">coactivator</a> <a href="/wiki/Nuclear_receptor_coactivator_3" title="Nuclear receptor coactivator 3">AIB-3</a> exceeds that of the <a href="/wiki/Corepressor_(genetics)" class="mw-redirect" title="Corepressor (genetics)">corepressor</a> <a href="/wiki/PAX2" title="PAX2">PAX2</a>, the expression of HER2 is upregulated in the presence of tamoxifen, leading to tamoxifen-resistant <a href="/wiki/Breast_cancer" title="Breast cancer">breast cancer</a>.<sup id="cite_ref-urlCORDIS_:_News_38-0" class="reference"><a href="#cite_note-urlCORDIS_:_News-38"><span class="cite-bracket">[</span>38<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-Hurtado1_2008_39-0" class="reference"><a href="#cite_note-Hurtado1_2008-39"><span class="cite-bracket">[</span>39<span class="cite-bracket">]</span></a></sup> </p><p>Among approved anti-HER2 therapeutics are also tyrosine kinase inhibitors (<a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a>, <a href="/wiki/Neratinib" title="Neratinib">Neratinib</a>, and <a href="/wiki/Tucatinib" title="Tucatinib">Tucatinib</a>) and antibody-drug conjugates (<a href="/wiki/Ado-trastuzumab_emtansine" class="mw-redirect" title="Ado-trastuzumab emtansine">ado-trastuzumab emtansine</a> and <a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">trastuzumab deruxtecan</a>).<sup id="cite_ref-40" class="reference"><a href="#cite_note-40"><span class="cite-bracket">[</span>40<span class="cite-bracket">]</span></a></sup> </p> <figure class="mw-halign-center" typeof="mw:File/Thumb"><a href="/wiki/File:3D_Dual_Color_Super_Resolution_Microscopy_Cremer_2010.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/3D_Dual_Color_Super_Resolution_Microscopy_Cremer_2010.png/960px-3D_Dual_Color_Super_Resolution_Microscopy_Cremer_2010.png" decoding="async" width="550" height="202" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/1a/3D_Dual_Color_Super_Resolution_Microscopy_Cremer_2010.png/1100px-3D_Dual_Color_Super_Resolution_Microscopy_Cremer_2010.png 2x" data-file-width="3486" data-file-height="1280" /></a><figcaption>Her2 and Her3 distribution on a breast cell, (3D Dual Colour Super Resolution Microscopy SPDMphymod / LIMON, marked with Alexa 488 and 568)</figcaption></figure> <div style="clear:both;" class=""></div> <div class="mw-heading mw-heading2"><h2 id="Diagnostics">Diagnostics</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=9" title="Edit section: Diagnostics"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HER2 testing is performed on <a href="/wiki/Breast_biopsy" title="Breast biopsy">breast biopsy</a> of breast cancer patients to assess prognosis and to determine suitability for trastuzumab therapy. It is important that trastuzumab is restricted to HER2-positive individuals as it is expensive and has been associated with cardiac toxicity.<sup id="cite_ref-pmid17687157_41-0" class="reference"><a href="#cite_note-pmid17687157-41"><span class="cite-bracket">[</span>41<span class="cite-bracket">]</span></a></sup> For HER2-positive tumors, the benefits of trastuzumab clearly outweigh the risks. </p><p>Tests are usually performed on <a href="/wiki/Breast_biopsy" title="Breast biopsy">breast biopsy</a> samples obtained by either <a href="/wiki/Fine-needle_aspiration" title="Fine-needle aspiration">fine-needle aspiration</a>, core needle biopsy, <a href="/wiki/Vacuum-assisted_breast_biopsy" title="Vacuum-assisted breast biopsy">vacuum-assisted breast biopsy</a>, or surgical excision. </p><p><a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">Immunohistochemistry</a> (IHC) is generally used to measure the amount of HER2 protein present in the sample, with <a href="/wiki/Fluorescence_in_situ_hybridisation" class="mw-redirect" title="Fluorescence in situ hybridisation">fluorescence in situ hybridisation</a> (FISH) being used on samples that are equivocal in IHC. However, in several locations, FISH is used initially, followed by IHC in equivocal cases.<sup id="cite_ref-pmid27899970_42-0" class="reference"><a href="#cite_note-pmid27899970-42"><span class="cite-bracket">[</span>42<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Immunohistochemistry">Immunohistochemistry</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=10" title="Edit section: Immunohistochemistry"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>By immunohistochemistry, the sample is given a score based on the cell membrane staining pattern. </p> <table class="wikitable" align="center"> <caption><a href="/wiki/Immunohistochemistry" title="Immunohistochemistry">Immunohistochemistry</a> </caption> <tbody><tr> <th>Score<sup id="cite_ref-Breastcancer_43-0" class="reference"><a href="#cite_note-Breastcancer-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-IqbalIqbal2014_44-0" class="reference"><a href="#cite_note-IqbalIqbal2014-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup></th> <th>Pattern<sup id="cite_ref-2018ASCO-CAP_45-0" class="reference"><a href="#cite_note-2018ASCO-CAP-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></th> <th>Status<sup id="cite_ref-Breastcancer_43-1" class="reference"><a href="#cite_note-Breastcancer-43"><span class="cite-bracket">[</span>43<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-IqbalIqbal2014_44-1" class="reference"><a href="#cite_note-IqbalIqbal2014-44"><span class="cite-bracket">[</span>44<span class="cite-bracket">]</span></a></sup> </th></tr> <tr> <td>0 </td> <td>Either:<sup id="cite_ref-2018ASCO-CAP_45-1" class="reference"><a href="#cite_note-2018ASCO-CAP-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> <ul><li>No staining observed.</li> <li>Incomplete membrane staining that is faint or barely perceptible and within ≤10% of the invasive tumor cells</li></ul> </td> <td rowspan="2">HER2 negative <br />(not present) </td></tr> <tr> <td>1+</td> <td>Incomplete membrane staining that is faint or barely perceptible and within >10% of the invasive tumor cells.<sup id="cite_ref-2018ASCO-CAP_45-2" class="reference"><a href="#cite_note-2018ASCO-CAP-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </td></tr> <tr> <td>2+</td> <td>Weak to moderate complete membrane staining observed in >10% of tumor cells.<sup id="cite_ref-2018ASCO-CAP_45-3" class="reference"><a href="#cite_note-2018ASCO-CAP-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup> </td> <td>Borderline/Equivocal </td></tr> <tr> <td>3+</td> <td>Circumferential membrane staining that is complete, intense, and in >10% of tumor cells.<sup id="cite_ref-2018ASCO-CAP_45-4" class="reference"><a href="#cite_note-2018ASCO-CAP-45"><span class="cite-bracket">[</span>45<span class="cite-bracket">]</span></a></sup></td> <td>HER2 positive </td></tr></tbody></table> <p>Micrographs showing each score:<sup id="cite_ref-46" class="reference"><a href="#cite_note-46"><span class="cite-bracket">[</span>46<span class="cite-bracket">]</span></a></sup> </p> <ul class="gallery mw-gallery-packed"> <li class="gallerybox" style="width: 175.33333333333px"> <div class="thumb" style="width: 173.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:HER2_immunohistochemistry_with_0_pattern.png" class="mw-file-description"><img alt="0" src="//upload.wikimedia.org/wikipedia/commons/8/81/HER2_immunohistochemistry_with_0_pattern.png" decoding="async" width="174" height="140" class="mw-file-element" data-file-width="172" data-file-height="139" /></a></span></div> <div class="gallerytext">0</div> </li> <li class="gallerybox" style="width: 171.33333333333px"> <div class="thumb" style="width: 169.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:HER2_immunohistochemistry_with_1_plus_pattern.png" class="mw-file-description" title="1+"><img alt="1+" src="//upload.wikimedia.org/wikipedia/commons/2/28/HER2_immunohistochemistry_with_1_plus_pattern.png" decoding="async" width="170" height="140" class="mw-file-element" data-file-width="168" data-file-height="139" /></a></span></div> <div class="gallerytext">1+</div> </li> <li class="gallerybox" style="width: 171.33333333333px"> <div class="thumb" style="width: 169.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:HER2_immunohistochemistry_with_2_plus_pattern.png" class="mw-file-description" title="2+"><img alt="2+" src="//upload.wikimedia.org/wikipedia/commons/4/40/HER2_immunohistochemistry_with_2_plus_pattern.png" decoding="async" width="170" height="140" class="mw-file-element" data-file-width="169" data-file-height="140" /></a></span></div> <div class="gallerytext">2+</div> </li> <li class="gallerybox" style="width: 170px"> <div class="thumb" style="width: 168px;"><span typeof="mw:File"><a href="/wiki/File:HER2_immunohistochemistry_with_3_plus_pattern.png" class="mw-file-description" title="3+"><img alt="3+" src="//upload.wikimedia.org/wikipedia/commons/7/7f/HER2_immunohistochemistry_with_3_plus_pattern.png" decoding="async" width="168" height="140" class="mw-file-element" data-file-width="168" data-file-height="140" /></a></span></div> <div class="gallerytext">3+</div> </li> </ul> <div class="mw-heading mw-heading3"><h3 id="Fluorescence_in_situ_hybridisation">Fluorescence <i>in situ</i> hybridisation</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=11" title="Edit section: Fluorescence in situ hybridisation"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>FISH can be used to measure the number of copies of the gene which are present and is thought to be more reliable than immunohistochemistry.<sup id="cite_ref-47" class="reference"><a href="#cite_note-47"><span class="cite-bracket">[</span>47<span class="cite-bracket">]</span></a></sup> It usually uses <i>chromosome enumeration probe 17</i> (CEP17) to count the amount of chromosomes. Hence, the HER2/CEP17 ratio reflects any amplification of HER2 as compared to the number of chromosomes. The signals of 20 cells are usually counted. </p> <ul class="gallery mw-gallery-packed"> <li class="gallerybox" style="width: 127.33333333333px"> <div class="thumb" style="width: 125.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_with_2_HER2_signals_and_3_CEP17_signals.png" class="mw-file-description" title="This cell displays 2 signals of HER2 (red) and 3 signals of CEP17 (green)"><img alt="This cell displays 2 signals of HER2 (red) and 3 signals of CEP17 (green)" src="//upload.wikimedia.org/wikipedia/commons/thumb/f/fb/HER2_FISH_with_2_HER2_signals_and_3_CEP17_signals.png/188px-HER2_FISH_with_2_HER2_signals_and_3_CEP17_signals.png" decoding="async" width="126" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/f/fb/HER2_FISH_with_2_HER2_signals_and_3_CEP17_signals.png 1.5x" data-file-width="225" data-file-height="215" /></a></span></div> <div class="gallerytext">This cell displays 2 signals of HER2 (red) and 3 signals of CEP17 (green)</div> </li> <li class="gallerybox" style="width: 100.66666666667px"> <div class="thumb" style="width: 98.666666666667px;"><span typeof="mw:File"><a href="/wiki/File:Counting_one_or_two_signals_on_HER2_FISH.png" class="mw-file-description" title="Two signals that are closer to each other than the signal diameter count as one."><img alt="Two signals that are closer to each other than the signal diameter count as one." src="//upload.wikimedia.org/wikipedia/commons/thumb/5/56/Counting_one_or_two_signals_on_HER2_FISH.png/250px-Counting_one_or_two_signals_on_HER2_FISH.png" decoding="async" width="99" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/56/Counting_one_or_two_signals_on_HER2_FISH.png/330px-Counting_one_or_two_signals_on_HER2_FISH.png 2x" data-file-width="1153" data-file-height="1405" /></a></span></div> <div class="gallerytext">Two signals that are closer to each other than the signal diameter count as one.</div> </li> <li class="gallerybox" style="width: 152.66666666667px"> <div class="thumb" style="width: 150.66666666667px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_with_debris.png" class="mw-file-description" title="One of these signals is too faint, and is presumably debris."><img alt="One of these signals is too faint, and is presumably debris." src="//upload.wikimedia.org/wikipedia/commons/thumb/b/b9/HER2_FISH_with_debris.png/226px-HER2_FISH_with_debris.png" decoding="async" width="151" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/b/b9/HER2_FISH_with_debris.png/339px-HER2_FISH_with_debris.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/b/b9/HER2_FISH_with_debris.png/452px-HER2_FISH_with_debris.png 2x" data-file-width="609" data-file-height="485" /></a></span></div> <div class="gallerytext">One of these signals is too faint, and is presumably debris.</div> </li> <li class="gallerybox" style="width: 111.33333333333px"> <div class="thumb" style="width: 109.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_with_only_one_signal_type.jpg" class="mw-file-description" title="Cells with only one type of signal are excluded from the count."><img alt="Cells with only one type of signal are excluded from the count." src="//upload.wikimedia.org/wikipedia/commons/e/e3/HER2_FISH_with_only_one_signal_type.jpg" decoding="async" width="110" height="120" class="mw-file-element" data-file-width="83" data-file-height="91" /></a></span></div> <div class="gallerytext">Cells with only one type of signal are excluded from the count.</div> </li> <li class="gallerybox" style="width: 92.666666666667px"> <div class="thumb" style="width: 90.666666666667px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_with_overlapping_cells.png" class="mw-file-description" title="Overlapping cells are also excluded from the count."><img alt="Overlapping cells are also excluded from the count." src="//upload.wikimedia.org/wikipedia/commons/thumb/0/0a/HER2_FISH_with_overlapping_cells.png/136px-HER2_FISH_with_overlapping_cells.png" decoding="async" width="91" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/0/0a/HER2_FISH_with_overlapping_cells.png 1.5x" data-file-width="138" data-file-height="183" /></a></span></div> <div class="gallerytext">Overlapping cells are also excluded from the count.</div> </li> <li class="gallerybox" style="width: 170px"> <div class="thumb" style="width: 168px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_with_a_yellow_signal.png" class="mw-file-description" title="A yellow signal counts as one red and one green (which are overlapping)"><img alt="A yellow signal counts as one red and one green (which are overlapping)" src="//upload.wikimedia.org/wikipedia/commons/thumb/5/5f/HER2_FISH_with_a_yellow_signal.png/330px-HER2_FISH_with_a_yellow_signal.png" decoding="async" width="168" height="120" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/5/5f/HER2_FISH_with_a_yellow_signal.png/500px-HER2_FISH_with_a_yellow_signal.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/5/5f/HER2_FISH_with_a_yellow_signal.png/503px-HER2_FISH_with_a_yellow_signal.png 2x" data-file-width="585" data-file-height="419" /></a></span></div> <div class="gallerytext">A yellow signal counts as one red and one green (which are overlapping)</div> </li> </ul> <ul class="gallery mw-gallery-packed"> <li class="gallerybox" style="width: 277.33333333333px"> <div class="thumb" style="width: 275.33333333333px;"><span typeof="mw:File"><a href="/wiki/File:Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png" class="mw-file-description"><img src="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png/413px-Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png" decoding="async" width="276" height="180" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png/619px-Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/8/8c/Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png/826px-Counting_HER2_versus_CEP17_probes_in_FISH_of_HER2_amplified_cell.png 2x" data-file-width="1203" data-file-height="787" /></a></span></div> <div class="gallerytext"></div> </li> <li class="gallerybox" style="width: 388px"> <div class="thumb" style="width: 386px;"><span typeof="mw:File"><a href="/wiki/File:HER2_FISH_algorithm.svg" class="mw-file-description" title="Algorithm for the evaluation of HER2 on fluorescence in situ hybridization (FISH).[48]"><img alt="Algorithm for the evaluation of HER2 on fluorescence in situ hybridization (FISH).[48]" src="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/HER2_FISH_algorithm.svg/579px-HER2_FISH_algorithm.svg.png" decoding="async" width="386" height="180" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/d/d2/HER2_FISH_algorithm.svg/868px-HER2_FISH_algorithm.svg.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/d/d2/HER2_FISH_algorithm.svg/1157px-HER2_FISH_algorithm.svg.png 2x" data-file-width="1257" data-file-height="587" /></a></span></div> <div class="gallerytext">Algorithm for the evaluation of HER2 on <a href="/wiki/Fluorescence_in_situ_hybridization" title="Fluorescence in situ hybridization">fluorescence <i>in situ</i> hybridization</a> (FISH).<sup id="cite_ref-HER2fish_48-0" class="reference"><a href="#cite_note-HER2fish-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup></div> </li> </ul> <table class="wikitable"> <caption>Classification of HER2 by <a href="/wiki/Fluorescence_in_situ_hybridization" title="Fluorescence in situ hybridization">fluorescence <i>in situ</i> hybridization</a> (FISH)<sup id="cite_ref-HER2fish_48-1" class="reference"><a href="#cite_note-HER2fish-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </caption> <tbody><tr> <td rowspan="2" colspan="2"> </td> <th colspan="2">HER2/CEP17 ratio </th></tr> <tr> <th>≥2.0 </th> <th><2.0 </th></tr> <tr> <th rowspan="2">Average HER2 copy number per cell </th> <th>≥4.0 </th> <td>HER2 positive </td> <td>Additional work-up required </td></tr> <tr> <th><4.0 </th> <td>Additional work-up required </td> <td>HER2 negative </td></tr></tbody></table> <p>If the initial HER2 result is negative for a needle biopsy of a primary breast cancer, a new HER2 test may be performed on the subsequent breast excision.<sup id="cite_ref-HER2fish_48-2" class="reference"><a href="#cite_note-HER2fish-48"><span class="cite-bracket">[</span>48<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading3"><h3 id="Serum">Serum</h3><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=12" title="Edit section: Serum"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>The extracellular domain of HER2 can be shed from the surface of tumour cells and enter the circulation. Measurement of serum HER2 by enzyme-linked immunosorbent assay (<a href="/wiki/ELISA" title="ELISA">ELISA</a>) offers a far less invasive method of determining HER2 status than a biopsy and consequently has been extensively investigated. Results so far have suggested that changes in serum HER2 concentrations may be useful in predicting response to trastuzumab therapy.<sup id="cite_ref-pmid18661530_49-0" class="reference"><a href="#cite_note-pmid18661530-49"><span class="cite-bracket">[</span>49<span class="cite-bracket">]</span></a></sup> However, its ability to determine eligibility for trastuzumab therapy is less clear.<sup id="cite_ref-pmid19255335_50-0" class="reference"><a href="#cite_note-pmid19255335-50"><span class="cite-bracket">[</span>50<span class="cite-bracket">]</span></a></sup> </p> <div class="mw-heading mw-heading2"><h2 id="Interactions">Interactions</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=13" title="Edit section: Interactions"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <p>HER2/neu has been shown to <a href="/wiki/Protein-protein_interaction" class="mw-redirect" title="Protein-protein interaction">interact</a> with: </p> <style data-mw-deduplicate="TemplateStyles:r1184024115">.mw-parser-output .div-col{margin-top:0.3em;column-width:30em}.mw-parser-output .div-col-small{font-size:90%}.mw-parser-output .div-col-rules{column-rule:1px solid #aaa}.mw-parser-output .div-col dl,.mw-parser-output .div-col ol,.mw-parser-output .div-col ul{margin-top:0}.mw-parser-output .div-col li,.mw-parser-output .div-col dd{page-break-inside:avoid;break-inside:avoid-column}</style><div class="div-col" style="column-width: 20em;"> <ul><li><a href="/wiki/Beta-catenin" class="mw-redirect" title="Beta-catenin">CTNNB1</a>,<sup id="cite_ref-pmid11950845_51-0" class="reference"><a href="#cite_note-pmid11950845-51"><span class="cite-bracket">[</span>51<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11245482_52-0" class="reference"><a href="#cite_note-pmid11245482-52"><span class="cite-bracket">[</span>52<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid7702605_53-0" class="reference"><a href="#cite_note-pmid7702605-53"><span class="cite-bracket">[</span>53<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/DLG4" title="DLG4">DLG4</a>,<sup id="cite_ref-pmid10839362_54-0" class="reference"><a href="#cite_note-pmid10839362-54"><span class="cite-bracket">[</span>54<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Erbin_(protein)" title="Erbin (protein)">Erbin</a>,<sup id="cite_ref-pmid11278603_55-0" class="reference"><a href="#cite_note-pmid11278603-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10878805_56-0" class="reference"><a href="#cite_note-pmid10878805-56"><span class="cite-bracket">[</span>56<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid12379659_57-0" class="reference"><a href="#cite_note-pmid12379659-57"><span class="cite-bracket">[</span>57<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/GRB2" title="GRB2">GRB2</a>,<sup id="cite_ref-pmid16729043_58-0" class="reference"><a href="#cite_note-pmid16729043-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11606575_59-0" class="reference"><a href="#cite_note-pmid11606575-59"><span class="cite-bracket">[</span>59<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9710588_60-0" class="reference"><a href="#cite_note-pmid9710588-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Heat_shock_protein_90kDa_alpha_(cytosolic),_member_A1" title="Heat shock protein 90kDa alpha (cytosolic), member A1">HSP90AA1</a>,<sup id="cite_ref-pmid11071886_61-0" class="reference"><a href="#cite_note-pmid11071886-61"><span class="cite-bracket">[</span>61<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid18655187_62-0" class="reference"><a href="#cite_note-pmid18655187-62"><span class="cite-bracket">[</span>62<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">IL6ST</a>,<sup id="cite_ref-pmid11821958_63-0" class="reference"><a href="#cite_note-pmid11821958-63"><span class="cite-bracket">[</span>63<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">MUC1</a>,<sup id="cite_ref-pmid12939402_64-0" class="reference"><a href="#cite_note-pmid12939402-64"><span class="cite-bracket">[</span>64<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid11278868_65-0" class="reference"><a href="#cite_note-pmid11278868-65"><span class="cite-bracket">[</span>65<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PICK1" title="PICK1">PICK1</a><sup id="cite_ref-pmid11278603_55-1" class="reference"><a href="#cite_note-pmid11278603-55"><span class="cite-bracket">[</span>55<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/PIK3R2" title="PIK3R2">PIK3R2</a>,<sup id="cite_ref-pmid1334406_66-0" class="reference"><a href="#cite_note-pmid1334406-66"><span class="cite-bracket">[</span>66<span class="cite-bracket">]</span></a></sup></li> <li><a href="/wiki/PLCG1" title="PLCG1">PLCG1</a>,<sup id="cite_ref-pmid1676673_67-0" class="reference"><a href="#cite_note-pmid1676673-67"><span class="cite-bracket">[</span>67<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid1683701_68-0" class="reference"><a href="#cite_note-pmid1683701-68"><span class="cite-bracket">[</span>68<span class="cite-bracket">]</span></a></sup> and</li> <li><a href="/wiki/SHC1" title="SHC1">SHC1</a>.<sup id="cite_ref-pmid16729043_58-1" class="reference"><a href="#cite_note-pmid16729043-58"><span class="cite-bracket">[</span>58<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid9710588_60-1" class="reference"><a href="#cite_note-pmid9710588-60"><span class="cite-bracket">[</span>60<span class="cite-bracket">]</span></a></sup><sup id="cite_ref-pmid10085134_69-0" class="reference"><a href="#cite_note-pmid10085134-69"><span class="cite-bracket">[</span>69<span class="cite-bracket">]</span></a></sup></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="See_also">See also</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=14" title="Edit section: See also"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a href="/wiki/SkBr3" class="mw-redirect" title="SkBr3">SkBr3 Cell Line</a>, over-expresses HER2</li></ul> <div class="mw-heading mw-heading2"><h2 id="References">References</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=15" title="Edit section: References"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239543626">.mw-parser-output .reflist{margin-bottom:0.5em;list-style-type:decimal}@media screen{.mw-parser-output .reflist{font-size:90%}}.mw-parser-output .reflist .references{font-size:100%;margin-bottom:0;list-style-type:inherit}.mw-parser-output .reflist-columns-2{column-width:30em}.mw-parser-output .reflist-columns-3{column-width:25em}.mw-parser-output .reflist-columns{margin-top:0.3em}.mw-parser-output .reflist-columns ol{margin-top:0}.mw-parser-output .reflist-columns li{page-break-inside:avoid;break-inside:avoid-column}.mw-parser-output .reflist-upper-alpha{list-style-type:upper-alpha}.mw-parser-output .reflist-upper-roman{list-style-type:upper-roman}.mw-parser-output .reflist-lower-alpha{list-style-type:lower-alpha}.mw-parser-output .reflist-lower-greek{list-style-type:lower-greek}.mw-parser-output .reflist-lower-roman{list-style-type:lower-roman}</style><div class="reflist"> <div class="mw-references-wrap mw-references-columns"><ol class="references"> <li id="cite_note-refGRCh38Ensembl-1"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCh38Ensembl_1-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCh38Ensembl_1-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Homo_sapiens/Gene/Summary?db=core;g=ENSG00000141736">GRCh38: Ensembl release 89: ENSG00000141736</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-refGRCm38Ensembl-2"><span class="mw-cite-backlink">^ <a href="#cite_ref-refGRCm38Ensembl_2-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-refGRCm38Ensembl_2-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text"><a rel="nofollow" class="external text" href="http://May2017.archive.ensembl.org/Mus_musculus/Gene/Summary?db=core;g=ENSMUSG00000062312">GRCm38: Ensembl release 89: ENSMUSG00000062312</a> – <a href="/wiki/Ensembl_genome_database_project" title="Ensembl genome database project">Ensembl</a>, May 2017</span> </li> <li id="cite_note-3"><span class="mw-cite-backlink"><b><a href="#cite_ref-3">^</a></b></span> <span class="reference-text"><style data-mw-deduplicate="TemplateStyles:r1238218222">.mw-parser-output cite.citation{font-style:inherit;word-wrap:break-word}.mw-parser-output .citation q{quotes:"\"""\"""'""'"}.mw-parser-output .citation:target{background-color:rgba(0,127,255,0.133)}.mw-parser-output .id-lock-free.id-lock-free a{background:url("//upload.wikimedia.org/wikipedia/commons/6/65/Lock-green.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-limited.id-lock-limited a,.mw-parser-output .id-lock-registration.id-lock-registration a{background:url("//upload.wikimedia.org/wikipedia/commons/d/d6/Lock-gray-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .id-lock-subscription.id-lock-subscription a{background:url("//upload.wikimedia.org/wikipedia/commons/a/aa/Lock-red-alt-2.svg")right 0.1em center/9px no-repeat}.mw-parser-output .cs1-ws-icon a{background:url("//upload.wikimedia.org/wikipedia/commons/4/4c/Wikisource-logo.svg")right 0.1em center/12px no-repeat}body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-free a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-limited a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-registration a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .id-lock-subscription a,body:not(.skin-timeless):not(.skin-minerva) .mw-parser-output .cs1-ws-icon a{background-size:contain;padding:0 1em 0 0}.mw-parser-output .cs1-code{color:inherit;background:inherit;border:none;padding:inherit}.mw-parser-output .cs1-hidden-error{display:none;color:var(--color-error,#d33)}.mw-parser-output .cs1-visible-error{color:var(--color-error,#d33)}.mw-parser-output .cs1-maint{display:none;color:#085;margin-left:0.3em}.mw-parser-output .cs1-kern-left{padding-left:0.2em}.mw-parser-output .cs1-kern-right{padding-right:0.2em}.mw-parser-output .citation .mw-selflink{font-weight:inherit}@media screen{.mw-parser-output .cs1-format{font-size:95%}html.skin-theme-clientpref-night .mw-parser-output .cs1-maint{color:#18911f}}@media screen and (prefers-color-scheme:dark){html.skin-theme-clientpref-os .mw-parser-output .cs1-maint{color:#18911f}}</style><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=2064">"Human PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Human+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D2064&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-4"><span class="mw-cite-backlink"><b><a href="#cite_ref-4">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Link&LinkName=gene_pubmed&from_uid=13866">"Mouse PubMed Reference:"</a>. <i>National Center for Biotechnology Information, U.S. National Library of Medicine</i>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=National+Center+for+Biotechnology+Information%2C+U.S.+National+Library+of+Medicine&rft.atitle=Mouse+PubMed+Reference%3A&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fsites%2Fentrez%3Fdb%3Dgene%26cmd%3DLink%26LinkName%3Dgene_pubmed%26from_uid%3D13866&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-5"><span class="mw-cite-backlink"><b><a href="#cite_ref-5">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/gene/2064">"ERBB2 erb-b2 receptor tyrosine kinase 2 [Homo sapiens (human)] - Gene - NCBI"</a>. <i>www.ncbi.nlm.nih.gov</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2016-06-14</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=www.ncbi.nlm.nih.gov&rft.atitle=ERBB2+erb-b2+receptor+tyrosine+kinase+2+%5BHomo+sapiens+%28human%29%5D+-+Gene+-+NCBI&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fgene%2F2064&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-6"><span class="mw-cite-backlink"><b><a href="#cite_ref-6">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://ghr.nlm.nih.gov/gene/ERBB2">"ERBB2"</a>. <i>Genetics Home Reference</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2016-06-19</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Genetics+Home+Reference&rft.atitle=ERBB2&rft_id=https%3A%2F%2Fghr.nlm.nih.gov%2Fgene%2FERBB2&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-7"><span class="mw-cite-backlink"><b><a href="#cite_ref-7">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBarhGunduz2015" class="citation book cs1">Barh D, Gunduz M (2015-01-22). <a rel="nofollow" class="external text" href="https://books.google.com/books?id=xZoXBgAAQBAJ"><i>Noninvasive Molecular Markers in Gynecologic Cancers</i></a>. CRC Press. p. 427. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4665-6939-3" title="Special:BookSources/978-1-4665-6939-3"><bdi>978-1-4665-6939-3</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Noninvasive+Molecular+Markers+in+Gynecologic+Cancers&rft.pages=427&rft.pub=CRC+Press&rft.date=2015-01-22&rft.isbn=978-1-4665-6939-3&rft.aulast=Barh&rft.aufirst=D&rft.au=Gunduz%2C+M&rft_id=https%3A%2F%2Fbooks.google.com%2Fbooks%3Fid%3DxZoXBgAAQBAJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-8"><span class="mw-cite-backlink"><b><a href="#cite_ref-8">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHsuHung2016" class="citation journal cs1">Hsu JL, Hung MC (2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215954">"The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer"</a>. <i>Cancer and Metastasis Reviews</i>. <b>35</b> (4): <span class="nowrap">575–</span>588. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs10555-016-9649-6">10.1007/s10555-016-9649-6</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215954">5215954</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27913999">27913999</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+and+Metastasis+Reviews&rft.atitle=The+role+of+HER2%2C+EGFR%2C+and+other+receptor+tyrosine+kinases+in+breast+cancer&rft.volume=35&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E575-%3C%2Fspan%3E588&rft.date=2016&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5215954%23id-name%3DPMC&rft_id=info%3Apmid%2F27913999&rft_id=info%3Adoi%2F10.1007%2Fs10555-016-9649-6&rft.aulast=Hsu&rft.aufirst=JL&rft.au=Hung%2C+MC&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5215954&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid23320171-9"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid23320171_9-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid23320171_9-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMitriConstantineO'Regan2012" class="citation journal cs1">Mitri Z, Constantine T, O'Regan R (2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539433">"The HER2 Receptor in Breast Cancer: Pathophysiology, Clinical Use, and New Advances in Therapy"</a>. <i>Chemotherapy Research and Practice</i>. <b>2012</b>: 743193. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1155%2F2012%2F743193">10.1155/2012/743193</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3539433">3539433</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23320171">23320171</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Chemotherapy+Research+and+Practice&rft.atitle=The+HER2+Receptor+in+Breast+Cancer%3A+Pathophysiology%2C+Clinical+Use%2C+and+New+Advances+in+Therapy&rft.volume=2012&rft.pages=743193&rft.date=2012&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3539433%23id-name%3DPMC&rft_id=info%3Apmid%2F23320171&rft_id=info%3Adoi%2F10.1155%2F2012%2F743193&rft.aulast=Mitri&rft.aufirst=Z&rft.au=Constantine%2C+T&rft.au=O%27Regan%2C+R&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3539433&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Coussens_1985-10"><span class="mw-cite-backlink"><b><a href="#cite_ref-Coussens_1985_10-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFCoussensYang-FengLiaoChen1985" class="citation journal cs1">Coussens L, Yang-Feng TL, Liao YC, Chen E, Gray A, McGrath J, et al. (December 1985). "Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene". <i>Science</i>. <b>230</b> (4730): <span class="nowrap">1132–</span>1139. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1985Sci...230.1132C">1985Sci...230.1132C</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscience.2999974">10.1126/science.2999974</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2999974">2999974</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science&rft.atitle=Tyrosine+kinase+receptor+with+extensive+homology+to+EGF+receptor+shares+chromosomal+location+with+neu+oncogene&rft.volume=230&rft.issue=4730&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1132-%3C%2Fspan%3E1139&rft.date=1985-12&rft_id=info%3Apmid%2F2999974&rft_id=info%3Adoi%2F10.1126%2Fscience.2999974&rft_id=info%3Abibcode%2F1985Sci...230.1132C&rft.aulast=Coussens&rft.aufirst=L&rft.au=Yang-Feng%2C+TL&rft.au=Liao%2C+YC&rft.au=Chen%2C+E&rft.au=Gray%2C+A&rft.au=McGrath%2C+J&rft.au=Seeburg%2C+PH&rft.au=Libermann%2C+TA&rft.au=Schlessinger%2C+J&rft.au=Francke%2C+U&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-11"><span class="mw-cite-backlink"><b><a href="#cite_ref-11">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBargmannHungWeinberg1986" class="citation journal cs1">Bargmann CI, Hung MC, Weinberg RA (January 1986). "The neu oncogene encodes an epidermal growth factor receptor-related protein". <i>Nature</i>. <b>319</b> (6050): <span class="nowrap">226–</span>230. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1986Natur.319..226B">1986Natur.319..226B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F319226a0">10.1038/319226a0</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/3945311">3945311</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=The+neu+oncogene+encodes+an+epidermal+growth+factor+receptor-related+protein&rft.volume=319&rft.issue=6050&rft.pages=%3Cspan+class%3D%22nowrap%22%3E226-%3C%2Fspan%3E230&rft.date=1986-01&rft_id=info%3Apmid%2F3945311&rft_id=info%3Adoi%2F10.1038%2F319226a0&rft_id=info%3Abibcode%2F1986Natur.319..226B&rft.aulast=Bargmann&rft.aufirst=CI&rft.au=Hung%2C+MC&rft.au=Weinberg%2C+RA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-12"><span class="mw-cite-backlink"><b><a href="#cite_ref-12">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFFukushigeMatsubaraYoshidaSasaki1986" class="citation journal cs1">Fukushige S, Matsubara K, Yoshida M, Sasaki M, Suzuki T, Semba K, et al. (March 1986). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC367597">"Localization of a novel v-erbB-related gene, c-erbB-2, on human chromosome 17 and its amplification in a gastric cancer cell line"</a>. <i>Molecular and Cellular Biology</i>. <b>6</b> (3): <span class="nowrap">955–</span>958. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.6.3.955-958.1986">10.1128/mcb.6.3.955-958.1986</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC367597">367597</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/2430175">2430175</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=Localization+of+a+novel+v-erbB-related+gene%2C+c-erbB-2%2C+on+human+chromosome+17+and+its+amplification+in+a+gastric+cancer+cell+line&rft.volume=6&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E955-%3C%2Fspan%3E958&rft.date=1986-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC367597%23id-name%3DPMC&rft_id=info%3Apmid%2F2430175&rft_id=info%3Adoi%2F10.1128%2Fmcb.6.3.955-958.1986&rft.aulast=Fukushige&rft.aufirst=S&rft.au=Matsubara%2C+K&rft.au=Yoshida%2C+M&rft.au=Sasaki%2C+M&rft.au=Suzuki%2C+T&rft.au=Semba%2C+K&rft.au=Toyoshima%2C+K&rft.au=Yamamoto%2C+T&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC367597&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-13"><span class="mw-cite-backlink"><b><a href="#cite_ref-13">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKeshamouniMattinglyReddy2002" class="citation journal cs1">Keshamouni VG, Mattingly RR, Reddy KB (June 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202351200">"Mechanism of 17-beta-estradiol-induced Erk1/2 activation in breast cancer cells. A role for HER2 AND PKC-delta"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (25): <span class="nowrap">22558–</span>22565. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M202351200">10.1074/jbc.M202351200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11960991">11960991</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Mechanism+of+17-beta-estradiol-induced+Erk1%2F2+activation+in+breast+cancer+cells.+A+role+for+HER2+AND+PKC-delta&rft.volume=277&rft.issue=25&rft.pages=%3Cspan+class%3D%22nowrap%22%3E22558-%3C%2Fspan%3E22565&rft.date=2002-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.M202351200&rft_id=info%3Apmid%2F11960991&rft.aulast=Keshamouni&rft.aufirst=VG&rft.au=Mattingly%2C+RR&rft.au=Reddy%2C+KB&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M202351200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-14"><span class="mw-cite-backlink"><b><a href="#cite_ref-14">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRusnakAffleckCockerillStubberfield2001" class="citation journal cs1">Rusnak DW, Affleck K, Cockerill SG, Stubberfield C, Harris R, Page M, et al. (October 2001). "The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer". <i>Cancer Research</i>. <b>61</b> (19): <span class="nowrap">7196–</span>7203. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11585755">11585755</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=The+characterization+of+novel%2C+dual+ErbB-2%2FEGFR%2C+tyrosine+kinase+inhibitors%3A+potential+therapy+for+cancer&rft.volume=61&rft.issue=19&rft.pages=%3Cspan+class%3D%22nowrap%22%3E7196-%3C%2Fspan%3E7203&rft.date=2001-10&rft_id=info%3Apmid%2F11585755&rft.aulast=Rusnak&rft.aufirst=DW&rft.au=Affleck%2C+K&rft.au=Cockerill%2C+SG&rft.au=Stubberfield%2C+C&rft.au=Harris%2C+R&rft.au=Page%2C+M&rft.au=Smith%2C+KJ&rft.au=Guntrip%2C+SB&rft.au=Carter%2C+MC&rft.au=Shaw%2C+RJ&rft.au=Jowett%2C+A&rft.au=Stables%2C+J&rft.au=Topley%2C+P&rft.au=Wood%2C+ER&rft.au=Brignola%2C+PS&rft.au=Kadwell%2C+SH&rft.au=Reep%2C+BR&rft.au=Mullin%2C+RJ&rft.au=Alligood%2C+KJ&rft.au=Keith%2C+BR&rft.au=Crosby%2C+RM&rft.au=Murray%2C+DM&rft.au=Knight%2C+WB&rft.au=Gilmer%2C+TM&rft.au=Lackey%2C+K&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Olayioye_2001-15"><span class="mw-cite-backlink"><b><a href="#cite_ref-Olayioye_2001_15-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFOlayioye2001" class="citation journal cs1">Olayioye MA (2001). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138705">"Update on HER-2 as a target for cancer therapy: intracellular signaling pathways of ErbB2/HER-2 and family members"</a>. <i>Breast Cancer Research</i>. <b>3</b> (6): <span class="nowrap">385–</span>389. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fbcr327">10.1186/bcr327</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC138705">138705</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11737890">11737890</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Breast+Cancer+Research&rft.atitle=Update+on+HER-2+as+a+target+for+cancer+therapy%3A+intracellular+signaling+pathways+of+ErbB2%2FHER-2+and+family+members&rft.volume=3&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E385-%3C%2Fspan%3E389&rft.date=2001&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC138705%23id-name%3DPMC&rft_id=info%3Apmid%2F11737890&rft_id=info%3Adoi%2F10.1186%2Fbcr327&rft.aulast=Olayioye&rft.aufirst=MA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC138705&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid19887469-16"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19887469_16-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRoyPerez2009" class="citation journal cs1">Roy V, Perez EA (November 2009). <a rel="nofollow" class="external text" href="https://doi.org/10.1634%2Ftheoncologist.2009-0142">"Beyond trastuzumab: small molecule tyrosine kinase inhibitors in HER-2-positive breast cancer"</a>. <i>The Oncologist</i>. <b>14</b> (11): <span class="nowrap">1061–</span>1069. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1634%2Ftheoncologist.2009-0142">10.1634/theoncologist.2009-0142</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19887469">19887469</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:207242039">207242039</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Oncologist&rft.atitle=Beyond+trastuzumab%3A+small+molecule+tyrosine+kinase+inhibitors+in+HER-2-positive+breast+cancer&rft.volume=14&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1061-%3C%2Fspan%3E1069&rft.date=2009-11&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A207242039%23id-name%3DS2CID&rft_id=info%3Apmid%2F19887469&rft_id=info%3Adoi%2F10.1634%2Ftheoncologist.2009-0142&rft.aulast=Roy&rft.aufirst=V&rft.au=Perez%2C+EA&rft_id=https%3A%2F%2Fdoi.org%2F10.1634%252Ftheoncologist.2009-0142&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid16236735-17"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid16236735_17-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBurstein2005" class="citation journal cs1">Burstein HJ (October 2005). "The distinctive nature of HER2-positive breast cancers". <i>The New England Journal of Medicine</i>. <b>353</b> (16): <span class="nowrap">1652–</span>1654. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1056%2FNEJMp058197">10.1056/NEJMp058197</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16236735">16236735</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:26675265">26675265</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+New+England+Journal+of+Medicine&rft.atitle=The+distinctive+nature+of+HER2-positive+breast+cancers&rft.volume=353&rft.issue=16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1652-%3C%2Fspan%3E1654&rft.date=2005-10&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A26675265%23id-name%3DS2CID&rft_id=info%3Apmid%2F16236735&rft_id=info%3Adoi%2F10.1056%2FNEJMp058197&rft.aulast=Burstein&rft.aufirst=HJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid17993237-18"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid17993237_18-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFTanYu2007" class="citation book cs1">Tan M, <a href="/wiki/Dihua_Yu" title="Dihua Yu">Yu D</a> (2007). <span class="id-lock-registration" title="Free registration required"><a rel="nofollow" class="external text" href="https://archive.org/details/breastcancerchem00dihu/page/119">"Molecular Mechanisms of ErbB2-Mediated Breast Cancer Chemoresistance"</a></span>. <i>Breast Cancer Chemosensitivity</i>. Advances in Experimental Medicine and Biology. Vol. 608. pp. <a rel="nofollow" class="external text" href="https://archive.org/details/breastcancerchem00dihu/page/119">119–29</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2F978-0-387-74039-3_9">10.1007/978-0-387-74039-3_9</a>. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-0-387-74037-9" title="Special:BookSources/978-0-387-74037-9"><bdi>978-0-387-74037-9</bdi></a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17993237">17993237</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Molecular+Mechanisms+of+ErbB2-Mediated+Breast+Cancer+Chemoresistance&rft.btitle=Breast+Cancer+Chemosensitivity&rft.series=Advances+in+Experimental+Medicine+and+Biology&rft.pages=119-29&rft.date=2007&rft_id=info%3Apmid%2F17993237&rft_id=info%3Adoi%2F10.1007%2F978-0-387-74039-3_9&rft.isbn=978-0-387-74037-9&rft.aulast=Tan&rft.aufirst=M&rft.au=Yu%2C+D&rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fbreastcancerchem00dihu%2Fpage%2F119&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-19"><span class="mw-cite-backlink"><b><a href="#cite_ref-19">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKumarAbbasAster2013" class="citation book cs1">Kumar V, Abbas A, Aster J (2013). <i>Robbins basic pathology</i>. Philadelphia: Elsevier/Saunders. p. 697. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4377-1781-5" title="Special:BookSources/978-1-4377-1781-5"><bdi>978-1-4377-1781-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Robbins+basic+pathology&rft.place=Philadelphia&rft.pages=697&rft.pub=Elsevier%2FSaunders&rft.date=2013&rft.isbn=978-1-4377-1781-5&rft.aulast=Kumar&rft.aufirst=V&rft.au=Abbas%2C+A&rft.au=Aster%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-20"><span class="mw-cite-backlink"><b><a href="#cite_ref-20">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKumarAbbasAster2013" class="citation book cs1">Kumar V, Abbas A, Aster J (2013). <i>Robbins basic pathology</i>. Philadelphia: Elsevier/Saunders. p. 179. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-4377-1781-5" title="Special:BookSources/978-1-4377-1781-5"><bdi>978-1-4377-1781-5</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=book&rft.btitle=Robbins+basic+pathology&rft.place=Philadelphia&rft.pages=179&rft.pub=Elsevier%2FSaunders&rft.date=2013&rft.isbn=978-1-4377-1781-5&rft.aulast=Kumar&rft.aufirst=V&rft.au=Abbas%2C+A&rft.au=Aster%2C+J&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-21"><span class="mw-cite-backlink"><b><a href="#cite_ref-21">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSantinBelloneRomanMcKenney2008" class="citation journal cs1">Santin AD, Bellone S, Roman JJ, McKenney JK, Pecorelli S (August 2008). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ijgo.2008.04.008">"Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu"</a>. <i>International Journal of Gynaecology and Obstetrics</i>. <b>102</b> (2): <span class="nowrap">128–</span>131. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fj.ijgo.2008.04.008">10.1016/j.ijgo.2008.04.008</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18555254">18555254</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:25674060">25674060</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=International+Journal+of+Gynaecology+and+Obstetrics&rft.atitle=Trastuzumab+treatment+in+patients+with+advanced+or+recurrent+endometrial+carcinoma+overexpressing+HER2%2Fneu&rft.volume=102&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E128-%3C%2Fspan%3E131&rft.date=2008-08&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A25674060%23id-name%3DS2CID&rft_id=info%3Apmid%2F18555254&rft_id=info%3Adoi%2F10.1016%2Fj.ijgo.2008.04.008&rft.aulast=Santin&rft.aufirst=AD&rft.au=Bellone%2C+S&rft.au=Roman%2C+JJ&rft.au=McKenney%2C+JK&rft.au=Pecorelli%2C+S&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fj.ijgo.2008.04.008&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Buza2014-22"><span class="mw-cite-backlink"><b><a href="#cite_ref-Buza2014_22-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBuzaRoqueSantin2014" class="citation journal cs1">Buza N, Roque DM, Santin AD (March 2014). "HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges". <i>Archives of Pathology & Laboratory Medicine</i>. <b>138</b> (3): <span class="nowrap">343–</span>350. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.5858%2Farpa.2012-0416-RA">10.5858/arpa.2012-0416-RA</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/24576030">24576030</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Archives+of+Pathology+%26+Laboratory+Medicine&rft.atitle=HER2%2Fneu+in+Endometrial+Cancer%3A+A+Promising+Therapeutic+Target+With+Diagnostic+Challenges&rft.volume=138&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E343-%3C%2Fspan%3E350&rft.date=2014-03&rft_id=info%3Adoi%2F10.5858%2Farpa.2012-0416-RA&rft_id=info%3Apmid%2F24576030&rft.aulast=Buza&rft.aufirst=N&rft.au=Roque%2C+DM&rft.au=Santin%2C+AD&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Rüschoff2012-23"><span class="mw-cite-backlink"><b><a href="#cite_ref-Rüschoff2012_23-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFRüschoffHannaBilousHofmann2012" class="citation journal cs1">Rüschoff J, Hanna W, Bilous M, Hofmann M, Osamura RY, Penault-Llorca F, et al. (May 2012). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2011.198">"HER2 testing in gastric cancer: a practical approach"</a>. <i>Modern Pathology</i>. <b>25</b> (5): <span class="nowrap">637–</span>650. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmodpathol.2011.198">10.1038/modpathol.2011.198</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22222640">22222640</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Modern+Pathology&rft.atitle=HER2+testing+in+gastric+cancer%3A+a+practical+approach&rft.volume=25&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E637-%3C%2Fspan%3E650&rft.date=2012-05&rft_id=info%3Adoi%2F10.1038%2Fmodpathol.2011.198&rft_id=info%3Apmid%2F22222640&rft.aulast=R%C3%BCschoff&rft.aufirst=J&rft.au=Hanna%2C+W&rft.au=Bilous%2C+M&rft.au=Hofmann%2C+M&rft.au=Osamura%2C+RY&rft.au=Penault-Llorca%2C+F&rft.au=van+de+Vijver%2C+M&rft.au=Viale%2C+G&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252Fmodpathol.2011.198&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid21556317-24"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21556317_24-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMeza-JuncoAuSawyer2011" class="citation journal cs1">Meza-Junco J, Au HJ, Sawyer MB (March 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085240">"Critical appraisal of trastuzumab in treatment of advanced stomach cancer"</a>. <i>Cancer Management and Research</i>. <b>3</b> (3): <span class="nowrap">57–</span>64. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.2147%2FCMAR.S12698">10.2147/CMAR.S12698</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085240">3085240</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21556317">21556317</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Management+and+Research&rft.atitle=Critical+appraisal+of+trastuzumab+in+treatment+of+advanced+stomach+cancer&rft.volume=3&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E57-%3C%2Fspan%3E64&rft.date=2011-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3085240%23id-name%3DPMC&rft_id=info%3Apmid%2F21556317&rft_id=info%3Adoi%2F10.2147%2FCMAR.S12698&rft.aulast=Meza-Junco&rft.aufirst=J&rft.au=Au%2C+HJ&rft.au=Sawyer%2C+MB&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3085240&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-25"><span class="mw-cite-backlink"><b><a href="#cite_ref-25">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFChioseaWilliamsGriffithThompson2015" class="citation journal cs1">Chiosea SI, Williams L, Griffith CC, Thompson LD, Weinreb I, Bauman JE, et al. (June 2015). "Molecular characterization of apocrine salivary duct carcinoma". <i>The American Journal of Surgical Pathology</i>. <b>39</b> (6): <span class="nowrap">744–</span>752. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1097%2FPAS.0000000000000410">10.1097/PAS.0000000000000410</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25723113">25723113</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:34106002">34106002</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+American+Journal+of+Surgical+Pathology&rft.atitle=Molecular+characterization+of+apocrine+salivary+duct+carcinoma&rft.volume=39&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E744-%3C%2Fspan%3E752&rft.date=2015-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A34106002%23id-name%3DS2CID&rft_id=info%3Apmid%2F25723113&rft_id=info%3Adoi%2F10.1097%2FPAS.0000000000000410&rft.aulast=Chiosea&rft.aufirst=SI&rft.au=Williams%2C+L&rft.au=Griffith%2C+CC&rft.au=Thompson%2C+LD&rft.au=Weinreb%2C+I&rft.au=Bauman%2C+JE&rft.au=Luvison%2C+A&rft.au=Roy%2C+S&rft.au=Seethala%2C+RR&rft.au=Nikiforova%2C+MN&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10318765-26"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10318765_26-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFNagyJeneiKirschSzöllosi1999" class="citation journal cs1">Nagy P, Jenei A, Kirsch AK, Szöllosi J, Damjanovich S, Jovin TM (June 1999). <a rel="nofollow" class="external text" href="http://jcs.biologists.org/content/112/11/1733.long">"Activation-dependent clustering of the erbB2 receptor tyrosine kinase detected by scanning near-field optical microscopy"</a>. <i>Journal of Cell Science</i>. <b>112</b> (11): <span class="nowrap">1733–</span>1741. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1242%2Fjcs.112.11.1733">10.1242/jcs.112.11.1733</a>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/2437%2F166028">2437/166028</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10318765">10318765</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Cell+Science&rft.atitle=Activation-dependent+clustering+of+the+erbB2+receptor+tyrosine+kinase+detected+by+scanning+near-field+optical+microscopy&rft.volume=112&rft.issue=11&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1733-%3C%2Fspan%3E1741&rft.date=1999-06&rft_id=info%3Ahdl%2F2437%2F166028&rft_id=info%3Apmid%2F10318765&rft_id=info%3Adoi%2F10.1242%2Fjcs.112.11.1733&rft.aulast=Nagy&rft.aufirst=P&rft.au=Jenei%2C+A&rft.au=Kirsch%2C+AK&rft.au=Sz%C3%B6llosi%2C+J&rft.au=Damjanovich%2C+S&rft.au=Jovin%2C+TM&rft_id=http%3A%2F%2Fjcs.biologists.org%2Fcontent%2F112%2F11%2F1733.long&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid21118230-27"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid21118230_27-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKaufmannMüllerHildenbrandHausmann2011" class="citation journal cs1">Kaufmann R, Müller P, Hildenbrand G, Hausmann M, Cremer C (April 2011). "Analysis of Her2/neu membrane protein clusters in different types of breast cancer cells using localization microscopy". <i>Journal of Microscopy</i>. <b>242</b> (1): <span class="nowrap">46–</span>54. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1111%2Fj.1365-2818.2010.03436.x">10.1111/j.1365-2818.2010.03436.x</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21118230">21118230</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:2119158">2119158</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Microscopy&rft.atitle=Analysis+of+Her2%2Fneu+membrane+protein+clusters+in+different+types+of+breast+cancer+cells+using+localization+microscopy&rft.volume=242&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E46-%3C%2Fspan%3E54&rft.date=2011-04&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A2119158%23id-name%3DS2CID&rft_id=info%3Apmid%2F21118230&rft_id=info%3Adoi%2F10.1111%2Fj.1365-2818.2010.03436.x&rft.aulast=Kaufmann&rft.aufirst=R&rft.au=M%C3%BCller%2C+P&rft.au=Hildenbrand%2C+G&rft.au=Hausmann%2C+M&rft.au=Cremer%2C+C&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-YonesakaZejnullahu2011-28"><span class="mw-cite-backlink"><b><a href="#cite_ref-YonesakaZejnullahu2011_28-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFYonesakaZejnullahuOkamotoSatoh2011" class="citation journal cs1">Yonesaka K, Zejnullahu K, Okamoto I, Satoh T, Cappuzzo F, Souglakos J, et al. (September 2011). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268675">"Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab"</a>. <i>Science Translational Medicine</i>. <b>3</b> (99): 99ra86. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1126%2Fscitranslmed.3002442">10.1126/scitranslmed.3002442</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268675">3268675</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/21900593">21900593</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Science+Translational+Medicine&rft.atitle=Activation+of+ERBB2+signaling+causes+resistance+to+the+EGFR-directed+therapeutic+antibody+cetuximab&rft.volume=3&rft.issue=99&rft.pages=99ra86&rft.date=2011-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3268675%23id-name%3DPMC&rft_id=info%3Apmid%2F21900593&rft_id=info%3Adoi%2F10.1126%2Fscitranslmed.3002442&rft.aulast=Yonesaka&rft.aufirst=K&rft.au=Zejnullahu%2C+K&rft.au=Okamoto%2C+I&rft.au=Satoh%2C+T&rft.au=Cappuzzo%2C+F&rft.au=Souglakos%2C+J&rft.au=Ercan%2C+D&rft.au=Rogers%2C+A&rft.au=Roncalli%2C+M&rft.au=Takeda%2C+M&rft.au=Fujisaka%2C+Y&rft.au=Philips%2C+J&rft.au=Shimizu%2C+T&rft.au=Maenishi%2C+O&rft.au=Cho%2C+Y&rft.au=Sun%2C+J&rft.au=Destro%2C+A&rft.au=Taira%2C+K&rft.au=Takeda%2C+K&rft.au=Okabe%2C+T&rft.au=Swanson%2C+J&rft.au=Itoh%2C+H&rft.au=Takada%2C+M&rft.au=Lifshits%2C+E&rft.au=Okuno%2C+K&rft.au=Engelman%2C+JA&rft.au=Shivdasani%2C+RA&rft.au=Nishio%2C+K&rft.au=Fukuoka%2C+M&rft.au=Varella-Garcia%2C+M&rft.au=Nakagawa%2C+K&rft.au=J%C3%A4nne%2C+PA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3268675&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-29"><span class="mw-cite-backlink"><b><a href="#cite_ref-29">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFPlumGebauerKrämerAlakus2019" class="citation journal cs1">Plum PS, Gebauer F, Krämer M, Alakus H, Berlth F, Chon SH, et al. (January 2019). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325716">"HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma"</a>. <i>BMC Cancer</i>. <b>19</b> (1): 38. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2Fs12885-018-5242-4">10.1186/s12885-018-5242-4</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325716">6325716</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/30621632">30621632</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMC+Cancer&rft.atitle=HER2%2Fneu+%28ERBB2%29+expression+and+gene+amplification+correlates+with+better+survival+in+esophageal+adenocarcinoma&rft.volume=19&rft.issue=1&rft.pages=38&rft.date=2019-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6325716%23id-name%3DPMC&rft_id=info%3Apmid%2F30621632&rft_id=info%3Adoi%2F10.1186%2Fs12885-018-5242-4&rft.aulast=Plum&rft.aufirst=PS&rft.au=Gebauer%2C+F&rft.au=Kr%C3%A4mer%2C+M&rft.au=Alakus%2C+H&rft.au=Berlth%2C+F&rft.au=Chon%2C+SH&rft.au=Schiffmann%2C+L&rft.au=Zander%2C+T&rft.au=B%C3%BCttner%2C+R&rft.au=H%C3%B6lscher%2C+AH&rft.au=Bruns%2C+CJ&rft.au=Quaas%2C+A&rft.au=Loeser%2C+H&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6325716&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-30"><span class="mw-cite-backlink"><b><a href="#cite_ref-30">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZhaoXingSongZhao2021" class="citation journal cs1">Zhao XK, Xing P, Song X, Zhao M, Zhao L, Dang Y, et al. (November 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586158">"Focal amplifications are associated with chromothripsis events and diverse prognoses in gastric cardia adenocarcinoma"</a>. <i>Nature Communications</i>. <b>12</b> (1): 6489. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2021NatCo..12.6489Z">2021NatCo..12.6489Z</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fs41467-021-26745-3">10.1038/s41467-021-26745-3</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8586158">8586158</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/34764264">34764264</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Communications&rft.atitle=Focal+amplifications+are+associated+with+chromothripsis+events+and+diverse+prognoses+in+gastric+cardia+adenocarcinoma&rft.volume=12&rft.issue=1&rft.pages=6489&rft.date=2021-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8586158%23id-name%3DPMC&rft_id=info%3Apmid%2F34764264&rft_id=info%3Adoi%2F10.1038%2Fs41467-021-26745-3&rft_id=info%3Abibcode%2F2021NatCo..12.6489Z&rft.aulast=Zhao&rft.aufirst=XK&rft.au=Xing%2C+P&rft.au=Song%2C+X&rft.au=Zhao%2C+M&rft.au=Zhao%2C+L&rft.au=Dang%2C+Y&rft.au=Lei%2C+LL&rft.au=Xu%2C+RH&rft.au=Han%2C+WL&rft.au=Wang%2C+PP&rft.au=Yang%2C+MM&rft.au=Hu%2C+JF&rft.au=Zhong%2C+K&rft.au=Zhou%2C+FY&rft.au=Han%2C+XN&rft.au=Meng%2C+CL&rft.au=Ji%2C+JJ&rft.au=Chen%2C+X&rft.au=Wang%2C+LD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC8586158&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-31"><span class="mw-cite-backlink"><b><a href="#cite_ref-31">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBrandt-RaufRackovskyPincus1990" class="citation journal cs1">Brandt-Rauf PW, Rackovsky S, Pincus MR (November 1990). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55017">"Correlation of the structure of the transmembrane domain of the neu oncogene-encoded p185 protein with its function"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>87</b> (21): <span class="nowrap">8660–</span>8664. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1990PNAS...87.8660B">1990PNAS...87.8660B</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.87.21.8660">10.1073/pnas.87.21.8660</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC55017">55017</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1978329">1978329</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Correlation+of+the+structure+of+the+transmembrane+domain+of+the+neu+oncogene-encoded+p185+protein+with+its+function&rft.volume=87&rft.issue=21&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8660-%3C%2Fspan%3E8664&rft.date=1990-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC55017%23id-name%3DPMC&rft_id=info%3Apmid%2F1978329&rft_id=info%3Adoi%2F10.1073%2Fpnas.87.21.8660&rft_id=info%3Abibcode%2F1990PNAS...87.8660B&rft.aulast=Brandt-Rauf&rft.aufirst=PW&rft.au=Rackovsky%2C+S&rft.au=Pincus%2C+MR&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC55017&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Mazières2013-32"><span class="mw-cite-backlink"><b><a href="#cite_ref-Mazières2013_32-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMazièresPetersLepageCortot2013" class="citation journal cs1">Mazières J, Peters S, Lepage B, Cortot AB, Barlesi F, Beau-Faller M, et al. (June 2013). "Lung cancer that harbors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives". <i>Journal of Clinical Oncology</i>. <b>31</b> (16): <span class="nowrap">1997–</span>2003. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FJCO.2012.45.6095">10.1200/JCO.2012.45.6095</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/23610105">23610105</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:37663670">37663670</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Lung+cancer+that+harbors+an+HER2+mutation%3A+epidemiologic+characteristics+and+therapeutic+perspectives&rft.volume=31&rft.issue=16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1997-%3C%2Fspan%3E2003&rft.date=2013-06&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A37663670%23id-name%3DS2CID&rft_id=info%3Apmid%2F23610105&rft_id=info%3Adoi%2F10.1200%2FJCO.2012.45.6095&rft.aulast=Mazi%C3%A8res&rft.aufirst=J&rft.au=Peters%2C+S&rft.au=Lepage%2C+B&rft.au=Cortot%2C+AB&rft.au=Barlesi%2C+F&rft.au=Beau-Faller%2C+M&rft.au=Besse%2C+B&rft.au=Blons%2C+H&rft.au=Mansuet-Lupo%2C+A&rft.au=Urban%2C+T&rft.au=Moro-Sibilot%2C+D&rft.au=Dansin%2C+E&rft.au=Chouaid%2C+C&rft.au=Wislez%2C+M&rft.au=Diebold%2C+J&rft.au=Felip%2C+E&rft.au=Rouquette%2C+I&rft.au=Milia%2C+JD&rft.au=Gautschi%2C+O&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid25848335-33"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid25848335_33-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMatesFletcherFreedmanEisen2015" class="citation journal cs1">Mates M, Fletcher GG, Freedman OC, Eisen A, Gandhi S, Trudeau ME, et al. (March 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381787">"Systemic targeted therapy for her2-positive early female breast cancer: a systematic review of the evidence for the 2014 Cancer Care Ontario systemic therapy guideline"</a>. <i>Current Oncology</i>. <b>22</b> (Suppl 1): <span class="nowrap">S114 –</span> <span class="nowrap">S122</span>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3747%2Fco.22.2322">10.3747/co.22.2322</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381787">4381787</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25848335">25848335</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Current+Oncology&rft.atitle=Systemic+targeted+therapy+for+her2-positive+early+female+breast+cancer%3A+a+systematic+review+of+the+evidence+for+the+2014+Cancer+Care+Ontario+systemic+therapy+guideline&rft.volume=22&rft.issue=Suppl+1&rft.pages=%3Cspan+class%3D%22nowrap%22%3ES114+-%3C%2Fspan%3E+%3Cspan+class%3D%22nowrap%22%3ES122%3C%2Fspan%3E&rft.date=2015-03&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4381787%23id-name%3DPMC&rft_id=info%3Apmid%2F25848335&rft_id=info%3Adoi%2F10.3747%2Fco.22.2322&rft.aulast=Mates&rft.aufirst=M&rft.au=Fletcher%2C+GG&rft.au=Freedman%2C+OC&rft.au=Eisen%2C+A&rft.au=Gandhi%2C+S&rft.au=Trudeau%2C+ME&rft.au=Dent%2C+SF&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4381787&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-34"><span class="mw-cite-backlink"><b><a href="#cite_ref-34">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHayesLippman2018" class="citation book cs1">Hayes DF, Lippman ME (2018). "Chapter 75: Breast Cancer". In Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J (eds.). <i>Harrison's Principles of Internal Medicine</i> (20th ed.). McGraw-Hill Education. <a href="/wiki/ISBN_(identifier)" class="mw-redirect" title="ISBN (identifier)">ISBN</a> <a href="/wiki/Special:BookSources/978-1-259-64403-0" title="Special:BookSources/978-1-259-64403-0"><bdi>978-1-259-64403-0</bdi></a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Chapter+75%3A+Breast+Cancer&rft.btitle=Harrison%27s+Principles+of+Internal+Medicine&rft.edition=20th&rft.pub=McGraw-Hill+Education&rft.date=2018&rft.isbn=978-1-259-64403-0&rft.aulast=Hayes&rft.aufirst=DF&rft.au=Lippman%2C+ME&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Le_2005-35"><span class="mw-cite-backlink"><b><a href="#cite_ref-Le_2005_35-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLePrueferBast2005" class="citation journal cs1">Le XF, Pruefer F, Bast RC (January 2005). <a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.4.1.1360">"HER2-targeting antibodies modulate the cyclin-dependent kinase inhibitor p27Kip1 via multiple signaling pathways"</a>. <i>Cell Cycle</i>. <b>4</b> (1): <span class="nowrap">87–</span>95. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.4.1.1360">10.4161/cc.4.1.1360</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15611642">15611642</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Cycle&rft.atitle=HER2-targeting+antibodies+modulate+the+cyclin-dependent+kinase+inhibitor+p27Kip1+via+multiple+signaling+pathways&rft.volume=4&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E87-%3C%2Fspan%3E95&rft.date=2005-01&rft_id=info%3Adoi%2F10.4161%2Fcc.4.1.1360&rft_id=info%3Apmid%2F15611642&rft.aulast=Le&rft.aufirst=XF&rft.au=Pruefer%2C+F&rft.au=Bast%2C+RC&rft_id=https%3A%2F%2Fdoi.org%2F10.4161%252Fcc.4.1.1360&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-36"><span class="mw-cite-backlink"><b><a href="#cite_ref-36">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFJiangRugo2015" class="citation journal cs1">Jiang H, Rugo HS (November 2015). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622301">"Human epidermal growth factor receptor 2 positive (HER2+) metastatic breast cancer: how the latest results are improving therapeutic options"</a>. <i>Therapeutic Advances in Medical Oncology</i>. <b>7</b> (6): <span class="nowrap">321–</span>339. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1177%2F1758834015599389">10.1177/1758834015599389</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4622301">4622301</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/26557900">26557900</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Therapeutic+Advances+in+Medical+Oncology&rft.atitle=Human+epidermal+growth+factor+receptor+2+positive+%28HER2%2B%29+metastatic+breast+cancer%3A+how+the+latest+results+are+improving+therapeutic+options&rft.volume=7&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E321-%3C%2Fspan%3E339&rft.date=2015-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4622301%23id-name%3DPMC&rft_id=info%3Apmid%2F26557900&rft_id=info%3Adoi%2F10.1177%2F1758834015599389&rft.aulast=Jiang&rft.aufirst=H&rft.au=Rugo%2C+HS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4622301&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid19552798-37"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19552798_37-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLoiSotiriouHaibe-KainsLallemand2009" class="citation journal cs1">Loi S, Sotiriou C, Haibe-Kains B, Lallemand F, Conus NM, Piccart MJ, et al. (June 2009). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706265">"Gene expression profiling identifies activated growth factor signaling in poor prognosis (Luminal-B) estrogen receptor positive breast cancer"</a>. <i>BMC Medical Genomics</i>. <b>2</b>: 37. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1755-8794-2-37">10.1186/1755-8794-2-37</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2706265">2706265</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19552798">19552798</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=BMC+Medical+Genomics&rft.atitle=Gene+expression+profiling+identifies+activated+growth+factor+signaling+in+poor+prognosis+%28Luminal-B%29+estrogen+receptor+positive+breast+cancer&rft.volume=2&rft.pages=37&rft.date=2009-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2706265%23id-name%3DPMC&rft_id=info%3Apmid%2F19552798&rft_id=info%3Adoi%2F10.1186%2F1755-8794-2-37&rft.aulast=Loi&rft.aufirst=S&rft.au=Sotiriou%2C+C&rft.au=Haibe-Kains%2C+B&rft.au=Lallemand%2C+F&rft.au=Conus%2C+NM&rft.au=Piccart%2C+MJ&rft.au=Speed%2C+TP&rft.au=McArthur%2C+GA&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2706265&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span> lay-url = <a rel="nofollow" class="external free" href="https://www.sciencedaily.com/releases/2010/05/100506112557.htm">https://www.sciencedaily.com/releases/2010/05/100506112557.htm</a> / lay-source = ScienceDaily</span> </li> <li id="cite_note-urlCORDIS_:_News-38"><span class="mw-cite-backlink"><b><a href="#cite_ref-urlCORDIS_:_News_38-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://web.archive.org/web/20090220060249/http://cordis.europa.eu/fetch?CALLER=EN_NEWS&ACTION=D&SESSION=&RCN=30093">"Study sheds new light on tamoxifen resistance"</a>. <i>Cordis News</i>. Cordis. 2008-11-13. Archived from <a rel="nofollow" class="external text" href="http://cordis.europa.eu/fetch?CALLER=EN_NEWS&ACTION=D&SESSION=&RCN=30093">the original</a> on 2009-02-20<span class="reference-accessdate">. Retrieved <span class="nowrap">2008-11-14</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Cordis+News&rft.atitle=Study+sheds+new+light+on+tamoxifen+resistance&rft.date=2008-11-13&rft_id=http%3A%2F%2Fcordis.europa.eu%2Ffetch%3FCALLER%3DEN_NEWS%26ACTION%3DD%26SESSION%3D%26RCN%3D30093&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-Hurtado1_2008-39"><span class="mw-cite-backlink"><b><a href="#cite_ref-Hurtado1_2008_39-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHurtadoHolmesGeistlingerHutcheson2008" class="citation journal cs1">Hurtado A, Holmes KA, Geistlinger TR, Hutcheson IR, Nicholson RI, Brown M, et al. (December 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920208">"Regulation of ERBB2 by oestrogen receptor-PAX2 determines response to tamoxifen"</a>. <i>Nature</i>. <b>456</b> (7222): <span class="nowrap">663–</span>666. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/2008Natur.456..663H">2008Natur.456..663H</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fnature07483">10.1038/nature07483</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920208">2920208</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19005469">19005469</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature&rft.atitle=Regulation+of+ERBB2+by+oestrogen+receptor-PAX2+determines+response+to+tamoxifen&rft.volume=456&rft.issue=7222&rft.pages=%3Cspan+class%3D%22nowrap%22%3E663-%3C%2Fspan%3E666&rft.date=2008-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2920208%23id-name%3DPMC&rft_id=info%3Apmid%2F19005469&rft_id=info%3Adoi%2F10.1038%2Fnature07483&rft_id=info%3Abibcode%2F2008Natur.456..663H&rft.aulast=Hurtado&rft.aufirst=A&rft.au=Holmes%2C+KA&rft.au=Geistlinger%2C+TR&rft.au=Hutcheson%2C+IR&rft.au=Nicholson%2C+RI&rft.au=Brown%2C+M&rft.au=Jiang%2C+J&rft.au=Howat%2C+WJ&rft.au=Ali%2C+S&rft.au=Carroll%2C+JS&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2920208&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-40"><span class="mw-cite-backlink"><b><a href="#cite_ref-40">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFVranićBešlijaGatalica2021" class="citation journal cs1">Vranić S, Bešlija S, Gatalica Z (February 2021). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861626">"Targeting HER2 expression in cancer: New drugs and new indications"</a>. <i>Bosnian Journal of Basic Medical Sciences</i>. <b>21</b> (1): <span class="nowrap">1–</span>4. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.17305%2Fbjbms.2020.4908">10.17305/bjbms.2020.4908</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7861626">7861626</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/32530388">32530388</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Bosnian+Journal+of+Basic+Medical+Sciences&rft.atitle=Targeting+HER2+expression+in+cancer%3A+New+drugs+and+new+indications&rft.volume=21&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1-%3C%2Fspan%3E4&rft.date=2021-02&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7861626%23id-name%3DPMC&rft_id=info%3Apmid%2F32530388&rft_id=info%3Adoi%2F10.17305%2Fbjbms.2020.4908&rft.aulast=Vrani%C4%87&rft.aufirst=S&rft.au=Be%C5%A1lija%2C+S&rft.au=Gatalica%2C+Z&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC7861626&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid17687157-41"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid17687157_41-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFTelliHuntCarlsonGuardino2007" class="citation journal cs1">Telli ML, Hunt SA, Carlson RW, Guardino AE (August 2007). "Trastuzumab-related cardiotoxicity: calling into question the concept of reversibility". <i>Journal of Clinical Oncology</i>. <b>25</b> (23): <span class="nowrap">3525–</span>3533. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FJCO.2007.11.0106">10.1200/JCO.2007.11.0106</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17687157">17687157</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Trastuzumab-related+cardiotoxicity%3A+calling+into+question+the+concept+of+reversibility&rft.volume=25&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3525-%3C%2Fspan%3E3533&rft.date=2007-08&rft_id=info%3Adoi%2F10.1200%2FJCO.2007.11.0106&rft_id=info%3Apmid%2F17687157&rft.aulast=Telli&rft.aufirst=ML&rft.au=Hunt%2C+SA&rft.au=Carlson%2C+RW&rft.au=Guardino%2C+AE&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid27899970-42"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid27899970_42-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFPetroniCaldarolaScamarcioGiotta2016" class="citation journal cs1">Petroni S, Caldarola L, Scamarcio R, Giotta F, Latorre A, Mangia A, et al. (November 2016). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103906">"FISH testing of HER2 immunohistochemistry 1+ invasive breast cancer with unfavorable characteristics"</a>. <i>Oncology Letters</i>. <b>12</b> (5): <span class="nowrap">3115–</span>3122. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.3892%2Fol.2016.5125">10.3892/ol.2016.5125</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103906">5103906</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/27899970">27899970</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncology+Letters&rft.atitle=FISH+testing+of+HER2+immunohistochemistry+1%2B+invasive+breast+cancer+with+unfavorable+characteristics&rft.volume=12&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3115-%3C%2Fspan%3E3122&rft.date=2016-11&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5103906%23id-name%3DPMC&rft_id=info%3Apmid%2F27899970&rft_id=info%3Adoi%2F10.3892%2Fol.2016.5125&rft.aulast=Petroni&rft.aufirst=S&rft.au=Caldarola%2C+L&rft.au=Scamarcio%2C+R&rft.au=Giotta%2C+F&rft.au=Latorre%2C+A&rft.au=Mangia%2C+A&rft.au=Simone%2C+G&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC5103906&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span> </span> </li> <li id="cite_note-Breastcancer-43"><span class="mw-cite-backlink">^ <a href="#cite_ref-Breastcancer_43-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-Breastcancer_43-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://www.breastcancer.org/screening-testing/ihc-immunohistochemistry-tests">"IHC (ImmunoHistoChemistry) Tests"</a>. <i>Breastcancer.org</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2019-10-04</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=Breastcancer.org&rft.atitle=IHC+%28ImmunoHistoChemistry%29+Tests&rft_id=https%3A%2F%2Fwww.breastcancer.org%2Fscreening-testing%2Fihc-immunohistochemistry-tests&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span> </span> </li> <li id="cite_note-IqbalIqbal2014-44"><span class="mw-cite-backlink">^ <a href="#cite_ref-IqbalIqbal2014_44-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-IqbalIqbal2014_44-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFIqbalIqbal2014" class="citation journal cs1">Iqbal N, Iqbal N (2014). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170925">"Human Epidermal Growth Factor Receptor 2 (HER2) in Cancers: Overexpression and Therapeutic Implications"</a>. <i>Molecular Biology International</i>. <b>2014</b>: 852748. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1155%2F2014%2F852748">10.1155/2014/852748</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170925">4170925</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/25276427">25276427</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Biology+International&rft.atitle=Human+Epidermal+Growth+Factor+Receptor+2+%28HER2%29+in+Cancers%3A+Overexpression+and+Therapeutic+Implications&rft.volume=2014&rft.pages=852748&rft.date=2014&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4170925%23id-name%3DPMC&rft_id=info%3Apmid%2F25276427&rft_id=info%3Adoi%2F10.1155%2F2014%2F852748&rft.aulast=Iqbal&rft.aufirst=N&rft.au=Iqbal%2C+N&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4170925&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-2018ASCO-CAP-45"><span class="mw-cite-backlink">^ <a href="#cite_ref-2018ASCO-CAP_45-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-2018ASCO-CAP_45-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-2018ASCO-CAP_45-2"><sup><i><b>c</b></i></sup></a> <a href="#cite_ref-2018ASCO-CAP_45-3"><sup><i><b>d</b></i></sup></a> <a href="#cite_ref-2018ASCO-CAP_45-4"><sup><i><b>e</b></i></sup></a></span> <span class="reference-text">2018 ASCO/CAP guidelines:<br />- <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite class="citation web cs1"><a rel="nofollow" class="external text" href="https://documents.cap.org/documents/algorithim-evaluation-her2.pdf">"Figure 1. Algorithm for evaluation of human epidermal growth factor receptor 2 (HER2) protein expression by immunohistochemistry (IHC) assay of the invasive component of a breast cancer specimen"</a> <span class="cs1-format">(PDF)</span>. <i>College of American Pathologists: Homepage</i><span class="reference-accessdate">. Retrieved <span class="nowrap">2022-09-12</span></span>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=unknown&rft.jtitle=College+of+American+Pathologists%3A+Homepage&rft.atitle=Figure+1.+Algorithm+for+evaluation+of+human+epidermal+growth+factor+receptor+2+%28HER2%29+protein+expression+by+immunohistochemistry+%28IHC%29+assay+of+the+invasive+component+of+a+breast+cancer+specimen.&rft_id=https%3A%2F%2Fdocuments.cap.org%2Fdocuments%2Falgorithim-evaluation-her2.pdf&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span><br />- <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAhnWooLeePark2020" class="citation journal cs1">Ahn S, Woo JW, Lee K, Park SY (January 2020). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986968">"HER2 status in breast cancer: changes in guidelines and complicating factors for interpretation"</a>. <i>Journal of Pathology and Translational Medicine</i>. <b>54</b> (1): <span class="nowrap">34–</span>44. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.4132%2Fjptm.2019.11.03">10.4132/jptm.2019.11.03</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986968">6986968</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/31693827">31693827</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Pathology+and+Translational+Medicine&rft.atitle=HER2+status+in+breast+cancer%3A+changes+in+guidelines+and+complicating+factors+for+interpretation&rft.volume=54&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E34-%3C%2Fspan%3E44&rft.date=2020-01&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6986968%23id-name%3DPMC&rft_id=info%3Apmid%2F31693827&rft_id=info%3Adoi%2F10.4132%2Fjptm.2019.11.03&rft.aulast=Ahn&rft.aufirst=S&rft.au=Woo%2C+JW&rft.au=Lee%2C+K&rft.au=Park%2C+SY&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC6986968&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span> </span> </li> <li id="cite_note-46"><span class="mw-cite-backlink"><b><a href="#cite_ref-46">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFNittaKellyPadillaWick2012" class="citation journal cs1">Nitta H, Kelly BD, Padilla M, Wick N, Brunhoeber P, Bai I, et al. (May 2012). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487810">"A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections"</a>. <i>Diagnostic Pathology</i>. <b>7</b>: 60. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1186%2F1746-1596-7-60">10.1186/1746-1596-7-60</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3487810">3487810</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/22647525">22647525</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Diagnostic+Pathology&rft.atitle=A+gene-protein+assay+for+human+epidermal+growth+factor+receptor+2+%28HER2%29%3A+brightfield+tricolor+visualization+of+HER2+protein%2C+the+HER2+gene%2C+and+chromosome+17+centromere+%28CEN17%29+in+formalin-fixed%2C+paraffin-embedded+breast+cancer+tissue+sections&rft.volume=7&rft.pages=60&rft.date=2012-05&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3487810%23id-name%3DPMC&rft_id=info%3Apmid%2F22647525&rft_id=info%3Adoi%2F10.1186%2F1746-1596-7-60&rft.aulast=Nitta&rft.aufirst=H&rft.au=Kelly%2C+BD&rft.au=Padilla%2C+M&rft.au=Wick%2C+N&rft.au=Brunhoeber%2C+P&rft.au=Bai%2C+I&rft.au=Singh%2C+S&rft.au=Ranger-Moore%2C+J&rft.au=Bieniarz%2C+C&rft.au=Tsuda%2C+H&rft.au=Grogan%2C+TM&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC3487810&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span><br />- "This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<a rel="nofollow" class="external free" href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</a>)"</span> </li> <li id="cite_note-47"><span class="mw-cite-backlink"><b><a href="#cite_ref-47">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGiulianoHurvitz2019" class="citation book cs1">Giuliano AE, Hurvitz SA (2019). "Breast Disorder". In Papadakis MA, McPhee SJ, Rabow MW (eds.). <i>Current Medical Diagnosis & Treatment</i>. New York, NY: McGraw-Hill.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rft.genre=bookitem&rft.atitle=Breast+Disorder&rft.btitle=Current+Medical+Diagnosis+%26+Treatment&rft.place=New+York%2C+NY&rft.pub=McGraw-Hill&rft.date=2019&rft.aulast=Giuliano&rft.aufirst=AE&rft.au=Hurvitz%2C+SA&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-HER2fish-48"><span class="mw-cite-backlink">^ <a href="#cite_ref-HER2fish_48-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-HER2fish_48-1"><sup><i><b>b</b></i></sup></a> <a href="#cite_ref-HER2fish_48-2"><sup><i><b>c</b></i></sup></a></span> <span class="reference-text">Diagram and table by Mikael Häggström, MD. Adapted from: <link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWolffHammondAllisonHarvey2018" class="citation journal cs1">Wolff AC, Hammond ME, Allison KH, Harvey BE, Mangu PB, Bartlett JM, et al. (July 2018). "Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update". <i>Journal of Clinical Oncology</i>. <b>36</b> (20): <span class="nowrap">2105–</span>2122. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FJCO.2018.77.8738">10.1200/JCO.2018.77.8738</a>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<a rel="nofollow" class="external text" href="https://hdl.handle.net/1805%2F18766">1805/18766</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/29846122">29846122</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:44143975">44143975</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Human+Epidermal+Growth+Factor+Receptor+2+Testing+in+Breast+Cancer%3A+American+Society+of+Clinical+Oncology%2FCollege+of+American+Pathologists+Clinical+Practice+Guideline+Focused+Update&rft.volume=36&rft.issue=20&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2105-%3C%2Fspan%3E2122&rft.date=2018-07&rft_id=info%3Ahdl%2F1805%2F18766&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A44143975%23id-name%3DS2CID&rft_id=info%3Apmid%2F29846122&rft_id=info%3Adoi%2F10.1200%2FJCO.2018.77.8738&rft.aulast=Wolff&rft.aufirst=AC&rft.au=Hammond%2C+ME&rft.au=Allison%2C+KH&rft.au=Harvey%2C+BE&rft.au=Mangu%2C+PB&rft.au=Bartlett%2C+JM&rft.au=Bilous%2C+M&rft.au=Ellis%2C+IO&rft.au=Fitzgibbons%2C+P&rft.au=Hanna%2C+W&rft.au=Jenkins%2C+RB&rft.au=Press%2C+MF&rft.au=Spears%2C+PA&rft.au=Vance%2C+GH&rft.au=Viale%2C+G&rft.au=McShane%2C+LM&rft.au=Dowsett%2C+M&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid18661530-49"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid18661530_49-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFAliCarneyEstevaFornier2008" class="citation journal cs1">Ali SM, Carney WP, Esteva FJ, Fornier M, Harris L, Köstler WJ, et al. (September 2008). "Serum HER-2/neu and relative resistance to trastuzumab-based therapy in patients with metastatic breast cancer". <i>Cancer</i>. <b>113</b> (6): <span class="nowrap">1294–</span>1301. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fcncr.23689">10.1002/cncr.23689</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18661530">18661530</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:7307111">7307111</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer&rft.atitle=Serum+HER-2%2Fneu+and+relative+resistance+to+trastuzumab-based+therapy+in+patients+with+metastatic+breast+cancer&rft.volume=113&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1294-%3C%2Fspan%3E1301&rft.date=2008-09&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A7307111%23id-name%3DS2CID&rft_id=info%3Apmid%2F18661530&rft_id=info%3Adoi%2F10.1002%2Fcncr.23689&rft.aulast=Ali&rft.aufirst=SM&rft.au=Carney%2C+WP&rft.au=Esteva%2C+FJ&rft.au=Fornier%2C+M&rft.au=Harris%2C+L&rft.au=K%C3%B6stler%2C+WJ&rft.au=Lotz%2C+JP&rft.au=Luftner%2C+D&rft.au=Pichon%2C+MF&rft.au=Lipton%2C+A&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid19255335-50"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid19255335_50-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLennonBartonBankenGianni2009" class="citation journal cs1">Lennon S, Barton C, Banken L, Gianni L, Marty M, Baselga J, et al. (April 2009). "Utility of serum HER2 extracellular domain assessment in clinical decision making: pooled analysis of four trials of trastuzumab in metastatic breast cancer". <i>Journal of Clinical Oncology</i>. <b>27</b> (10): <span class="nowrap">1685–</span>1693. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1200%2FJCO.2008.16.8351">10.1200/JCO.2008.16.8351</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/19255335">19255335</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Clinical+Oncology&rft.atitle=Utility+of+serum+HER2+extracellular+domain+assessment+in+clinical+decision+making%3A+pooled+analysis+of+four+trials+of+trastuzumab+in+metastatic+breast+cancer&rft.volume=27&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1685-%3C%2Fspan%3E1693&rft.date=2009-04&rft_id=info%3Adoi%2F10.1200%2FJCO.2008.16.8351&rft_id=info%3Apmid%2F19255335&rft.aulast=Lennon&rft.aufirst=S&rft.au=Barton%2C+C&rft.au=Banken%2C+L&rft.au=Gianni%2C+L&rft.au=Marty%2C+M&rft.au=Baselga%2C+J&rft.au=Leyland-Jones%2C+B&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11950845-51"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11950845_51-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchroederAdrianceMcConnellThompson2002" class="citation journal cs1">Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, Gendler SJ (June 2002). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M201975200">"ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas"</a>. <i>The Journal of Biological Chemistry</i>. <b>277</b> (25): <span class="nowrap">22692–</span>22698. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M201975200">10.1074/jbc.M201975200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11950845">11950845</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=ErbB-beta-catenin+complexes+are+associated+with+human+infiltrating+ductal+breast+and+murine+mammary+tumor+virus+%28MMTV%29-Wnt-1+and+MMTV-c-Neu+transgenic+carcinomas&rft.volume=277&rft.issue=25&rft.pages=%3Cspan+class%3D%22nowrap%22%3E22692-%3C%2Fspan%3E22698&rft.date=2002-06&rft_id=info%3Adoi%2F10.1074%2Fjbc.M201975200&rft_id=info%3Apmid%2F11950845&rft.aulast=Schroeder&rft.aufirst=JA&rft.au=Adriance%2C+MC&rft.au=McConnell%2C+EJ&rft.au=Thompson%2C+MC&rft.au=Pockaj%2C+B&rft.au=Gendler%2C+SJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M201975200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11245482-52"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11245482_52-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBonviniAnRosolenNguyen2001" class="citation journal cs1">Bonvini P, An WG, Rosolen A, Nguyen P, Trepel J, Garcia de Herreros A, et al. (February 2001). "Geldanamycin abrogates ErbB2 association with proteasome-resistant beta-catenin in melanoma cells, increases beta-catenin-E-cadherin association, and decreases beta-catenin-sensitive transcription". <i>Cancer Research</i>. <b>61</b> (4): <span class="nowrap">1671–</span>1677. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11245482">11245482</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cancer+Research&rft.atitle=Geldanamycin+abrogates+ErbB2+association+with+proteasome-resistant+beta-catenin+in+melanoma+cells%2C+increases+beta-catenin-E-cadherin+association%2C+and+decreases+beta-catenin-sensitive+transcription&rft.volume=61&rft.issue=4&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1671-%3C%2Fspan%3E1677&rft.date=2001-02&rft_id=info%3Apmid%2F11245482&rft.aulast=Bonvini&rft.aufirst=P&rft.au=An%2C+WG&rft.au=Rosolen%2C+A&rft.au=Nguyen%2C+P&rft.au=Trepel%2C+J&rft.au=Garcia+de+Herreros%2C+A&rft.au=Dunach%2C+M&rft.au=Neckers%2C+LM&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid7702605-53"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid7702605_53-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFKanaiOchiaiShibataOyama1995" class="citation journal cs1">Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, Akimoto S, et al. (March 1995). "c-erbB-2 gene product directly associates with beta-catenin and plakoglobin". <i>Biochemical and Biophysical Research Communications</i>. <b>208</b> (3): <span class="nowrap">1067–</span>1072. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1006%2Fbbrc.1995.1443">10.1006/bbrc.1995.1443</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/7702605">7702605</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Biochemical+and+Biophysical+Research+Communications&rft.atitle=c-erbB-2+gene+product+directly+associates+with+beta-catenin+and+plakoglobin&rft.volume=208&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1067-%3C%2Fspan%3E1072&rft.date=1995-03&rft_id=info%3Adoi%2F10.1006%2Fbbrc.1995.1443&rft_id=info%3Apmid%2F7702605&rft.aulast=Kanai&rft.aufirst=Y&rft.au=Ochiai%2C+A&rft.au=Shibata%2C+T&rft.au=Oyama%2C+T&rft.au=Ushijima%2C+S&rft.au=Akimoto%2C+S&rft.au=Hirohashi%2C+S&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10839362-54"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10839362_54-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHuangWonAliWang2000" class="citation journal cs1">Huang YZ, Won S, Ali DW, Wang Q, Tanowitz M, Du QS, et al. (May 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0896-6273%2800%2981176-9">"Regulation of neuregulin signaling by PSD-95 interacting with ErbB4 at CNS synapses"</a>. <i>Neuron</i>. <b>26</b> (2): <span class="nowrap">443–</span>455. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1016%2Fs0896-6273%2800%2981176-9">10.1016/s0896-6273(00)81176-9</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10839362">10839362</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:1429113">1429113</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Neuron&rft.atitle=Regulation+of+neuregulin+signaling+by+PSD-95+interacting+with+ErbB4+at+CNS+synapses&rft.volume=26&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E443-%3C%2Fspan%3E455&rft.date=2000-05&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A1429113%23id-name%3DS2CID&rft_id=info%3Apmid%2F10839362&rft_id=info%3Adoi%2F10.1016%2Fs0896-6273%2800%2981176-9&rft.aulast=Huang&rft.aufirst=YZ&rft.au=Won%2C+S&rft.au=Ali%2C+DW&rft.au=Wang%2C+Q&rft.au=Tanowitz%2C+M&rft.au=Du%2C+QS&rft.au=Pelkey%2C+KA&rft.au=Yang%2C+DJ&rft.au=Xiong%2C+WC&rft.au=Salter%2C+MW&rft.au=Mei%2C+L&rft_id=https%3A%2F%2Fdoi.org%2F10.1016%252Fs0896-6273%252800%252981176-9&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11278603-55"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid11278603_55-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid11278603_55-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFJaulin-BastardSaitoLe_BivicOllendorff2001" class="citation journal cs1">Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, et al. (May 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M010032200">"The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins"</a>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (18): <span class="nowrap">15256–</span>15263. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M010032200">10.1074/jbc.M010032200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11278603">11278603</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=The+ERBB2%2FHER2+receptor+differentially+interacts+with+ERBIN+and+PICK1+PSD-95%2FDLG%2FZO-1+domain+proteins&rft.volume=276&rft.issue=18&rft.pages=%3Cspan+class%3D%22nowrap%22%3E15256-%3C%2Fspan%3E15263&rft.date=2001-05&rft_id=info%3Adoi%2F10.1074%2Fjbc.M010032200&rft_id=info%3Apmid%2F11278603&rft.aulast=Jaulin-Bastard&rft.aufirst=F&rft.au=Saito%2C+H&rft.au=Le+Bivic%2C+A&rft.au=Ollendorff%2C+V&rft.au=Marchetto%2C+S&rft.au=Birnbaum%2C+D&rft.au=Borg%2C+JP&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M010032200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10878805-56"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10878805_56-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBilderBirnbaumBorgBryant2000" class="citation journal cs1">Bilder D, Birnbaum D, Borg JP, Bryant P, Huigbretse J, Jansen E, et al. (July 2000). <a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35017119">"Collective nomenclature for LAP proteins"</a>. <i>Nature Cell Biology</i>. <b>2</b> (7): E114. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1038%2F35017119">10.1038/35017119</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10878817">10878817</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19749569">19749569</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Nature+Cell+Biology&rft.atitle=Collective+nomenclature+for+LAP+proteins&rft.volume=2&rft.issue=7&rft.pages=E114&rft.date=2000-07&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19749569%23id-name%3DS2CID&rft_id=info%3Apmid%2F10878817&rft_id=info%3Adoi%2F10.1038%2F35017119&rft.aulast=Bilder&rft.aufirst=D&rft.au=Birnbaum%2C+D&rft.au=Borg%2C+JP&rft.au=Bryant%2C+P&rft.au=Huigbretse%2C+J&rft.au=Jansen%2C+E&rft.au=Kennedy%2C+MB&rft.au=Labouesse%2C+M&rft.au=Legouis%2C+R&rft.au=Mechler%2C+B&rft.au=Perrimon%2C+N&rft.au=Petit%2C+M&rft.au=Sinha%2C+P&rft_id=https%3A%2F%2Fdoi.org%2F10.1038%252F35017119&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid12379659-57"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12379659_57-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFHuangZangXiongLuo2003" class="citation journal cs1">Huang YZ, Zang M, Xiong WC, Luo Z, Mei L (January 2003). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M205413200">"Erbin suppresses the MAP kinase pathway"</a>. <i>The Journal of Biological Chemistry</i>. <b>278</b> (2): <span class="nowrap">1108–</span>1114. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M205413200">10.1074/jbc.M205413200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12379659">12379659</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Erbin+suppresses+the+MAP+kinase+pathway&rft.volume=278&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E1108-%3C%2Fspan%3E1114&rft.date=2003-01&rft_id=info%3Adoi%2F10.1074%2Fjbc.M205413200&rft_id=info%3Apmid%2F12379659&rft.aulast=Huang&rft.aufirst=YZ&rft.au=Zang%2C+M&rft.au=Xiong%2C+WC&rft.au=Luo%2C+Z&rft.au=Mei%2C+L&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M205413200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid16729043-58"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid16729043_58-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid16729043_58-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchulzeDengMann2005" class="citation journal cs1">Schulze WX, Deng L, Mann M (2005). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681463">"Phosphotyrosine interactome of the ErbB-receptor kinase family"</a>. <i>Molecular Systems Biology</i>. <b>1</b>: 2005.0008. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fmsb4100012">10.1038/msb4100012</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1681463">1681463</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16729043">16729043</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Systems+Biology&rft.atitle=Phosphotyrosine+interactome+of+the+ErbB-receptor+kinase+family&rft.volume=1&rft.pages=2005.0008&rft.date=2005&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1681463%23id-name%3DPMC&rft_id=info%3Apmid%2F16729043&rft_id=info%3Adoi%2F10.1038%2Fmsb4100012&rft.aulast=Schulze&rft.aufirst=WX&rft.au=Deng%2C+L&rft.au=Mann%2C+M&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1681463&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11606575-59"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11606575_59-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBourguignonZhuZhouDiedrich2001" class="citation journal cs1">Bourguignon LY, Zhu H, Zhou B, Diedrich F, Singleton PA, Hung MC (December 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M106759200">"Hyaluronan promotes CD44v3-Vav2 interaction with Grb2-p185(HER2) and induces Rac1 and Ras signaling during ovarian tumor cell migration and growth"</a>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (52): <span class="nowrap">48679–</span>48692. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M106759200">10.1074/jbc.M106759200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11606575">11606575</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Hyaluronan+promotes+CD44v3-Vav2+interaction+with+Grb2-p185%28HER2%29+and+induces+Rac1+and+Ras+signaling+during+ovarian+tumor+cell+migration+and+growth&rft.volume=276&rft.issue=52&rft.pages=%3Cspan+class%3D%22nowrap%22%3E48679-%3C%2Fspan%3E48692&rft.date=2001-12&rft_id=info%3Adoi%2F10.1074%2Fjbc.M106759200&rft_id=info%3Apmid%2F11606575&rft.aulast=Bourguignon&rft.aufirst=LY&rft.au=Zhu%2C+H&rft.au=Zhou%2C+B&rft.au=Diedrich%2C+F&rft.au=Singleton%2C+PA&rft.au=Hung%2C+MC&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M106759200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid9710588-60"><span class="mw-cite-backlink">^ <a href="#cite_ref-pmid9710588_60-0"><sup><i><b>a</b></i></sup></a> <a href="#cite_ref-pmid9710588_60-1"><sup><i><b>b</b></i></sup></a></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFOlayioyeGraus-PortaBeerliRohrer1998" class="citation journal cs1">Olayioye MA, Graus-Porta D, Beerli RR, Rohrer J, Gay B, Hynes NE (September 1998). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109089">"ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner"</a>. <i>Molecular and Cellular Biology</i>. <b>18</b> (9): <span class="nowrap">5042–</span>5051. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1128%2Fmcb.18.9.5042">10.1128/mcb.18.9.5042</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC109089">109089</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/9710588">9710588</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+and+Cellular+Biology&rft.atitle=ErbB-1+and+ErbB-2+acquire+distinct+signaling+properties+dependent+upon+their+dimerization+partner&rft.volume=18&rft.issue=9&rft.pages=%3Cspan+class%3D%22nowrap%22%3E5042-%3C%2Fspan%3E5051&rft.date=1998-09&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109089%23id-name%3DPMC&rft_id=info%3Apmid%2F9710588&rft_id=info%3Adoi%2F10.1128%2Fmcb.18.9.5042&rft.aulast=Olayioye&rft.aufirst=MA&rft.au=Graus-Porta%2C+D&rft.au=Beerli%2C+RR&rft.au=Rohrer%2C+J&rft.au=Gay%2C+B&rft.au=Hynes%2C+NE&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC109089&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11071886-61"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11071886_61-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFXuMimnaughRosserNicchitta2001" class="citation journal cs1">Xu W, Mimnaugh E, Rosser MF, Nicchitta C, Marcu M, Yarden Y, et al. (February 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M006864200">"Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90"</a>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (5): <span class="nowrap">3702–</span>3708. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M006864200">10.1074/jbc.M006864200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11071886">11071886</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Sensitivity+of+mature+Erbb2+to+geldanamycin+is+conferred+by+its+kinase+domain+and+is+mediated+by+the+chaperone+protein+Hsp90&rft.volume=276&rft.issue=5&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3702-%3C%2Fspan%3E3708&rft.date=2001-02&rft_id=info%3Adoi%2F10.1074%2Fjbc.M006864200&rft_id=info%3Apmid%2F11071886&rft.aulast=Xu&rft.aufirst=W&rft.au=Mimnaugh%2C+E&rft.au=Rosser%2C+MF&rft.au=Nicchitta%2C+C&rft.au=Marcu%2C+M&rft.au=Yarden%2C+Y&rft.au=Neckers%2C+L&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M006864200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid18655187-62"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid18655187_62-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFJeongAnKwonLi2008" class="citation journal cs1">Jeong JH, An JY, Kwon YT, Li LY, Lee YJ (October 2008). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575035">"Quercetin-induced ubiquitination and down-regulation of Her-2/neu"</a>. <i>Journal of Cellular Biochemistry</i>. <b>105</b> (2): <span class="nowrap">585–</span>595. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fjcb.21859">10.1002/jcb.21859</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2575035">2575035</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/18655187">18655187</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Journal+of+Cellular+Biochemistry&rft.atitle=Quercetin-induced+ubiquitination+and+down-regulation+of+Her-2%2Fneu&rft.volume=105&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E585-%3C%2Fspan%3E595&rft.date=2008-10&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2575035%23id-name%3DPMC&rft_id=info%3Apmid%2F18655187&rft_id=info%3Adoi%2F10.1002%2Fjcb.21859&rft.aulast=Jeong&rft.aufirst=JH&rft.au=An%2C+JY&rft.au=Kwon%2C+YT&rft.au=Li%2C+LY&rft.au=Lee%2C+YJ&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2575035&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11821958-63"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11821958_63-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGrantHammacherDouglasGoss2002" class="citation journal cs1">Grant SL, Hammacher A, Douglas AM, Goss GA, Mansfield RK, Heath JK, et al. (January 2002). "An unexpected biochemical and functional interaction between gp130 and the EGF receptor family in breast cancer cells". <i>Oncogene</i>. <b>21</b> (3): <span class="nowrap">460–</span>474. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1038%2Fsj.onc.1205100">10.1038/sj.onc.1205100</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11821958">11821958</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:19754641">19754641</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Oncogene&rft.atitle=An+unexpected+biochemical+and+functional+interaction+between+gp130+and+the+EGF+receptor+family+in+breast+cancer+cells&rft.volume=21&rft.issue=3&rft.pages=%3Cspan+class%3D%22nowrap%22%3E460-%3C%2Fspan%3E474&rft.date=2002-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A19754641%23id-name%3DS2CID&rft_id=info%3Apmid%2F11821958&rft_id=info%3Adoi%2F10.1038%2Fsj.onc.1205100&rft.aulast=Grant&rft.aufirst=SL&rft.au=Hammacher%2C+A&rft.au=Douglas%2C+AM&rft.au=Goss%2C+GA&rft.au=Mansfield%2C+RK&rft.au=Heath%2C+JK&rft.au=Begley%2C+CG&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid12939402-64"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid12939402_64-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLiYuRenChen2003" class="citation journal cs1">Li Y, Yu WH, Ren J, Chen W, Huang L, Kharbanda S, et al. (August 2003). "Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein". <i>Molecular Cancer Research</i>. <b>1</b> (10): <span class="nowrap">765–</span>775. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/12939402">12939402</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Molecular+Cancer+Research&rft.atitle=Heregulin+targets+gamma-catenin+to+the+nucleolus+by+a+mechanism+dependent+on+the+DF3%2FMUC1+oncoprotein&rft.volume=1&rft.issue=10&rft.pages=%3Cspan+class%3D%22nowrap%22%3E765-%3C%2Fspan%3E775&rft.date=2003-08&rft_id=info%3Apmid%2F12939402&rft.aulast=Li&rft.aufirst=Y&rft.au=Yu%2C+WH&rft.au=Ren%2C+J&rft.au=Chen%2C+W&rft.au=Huang%2C+L&rft.au=Kharbanda%2C+S&rft.au=Loda%2C+M&rft.au=Kufe%2C+D&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid11278868-65"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid11278868_65-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFSchroederThompsonGardnerGendler2001" class="citation journal cs1">Schroeder JA, Thompson MC, Gardner MM, Gendler SJ (April 2001). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M011248200">"Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland"</a>. <i>The Journal of Biological Chemistry</i>. <b>276</b> (16): <span class="nowrap">13057–</span>13064. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.M011248200">10.1074/jbc.M011248200</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/11278868">11278868</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=Transgenic+MUC1+interacts+with+epidermal+growth+factor+receptor+and+correlates+with+mitogen-activated+protein+kinase+activation+in+the+mouse+mammary+gland&rft.volume=276&rft.issue=16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E13057-%3C%2Fspan%3E13064&rft.date=2001-04&rft_id=info%3Adoi%2F10.1074%2Fjbc.M011248200&rft_id=info%3Apmid%2F11278868&rft.aulast=Schroeder&rft.aufirst=JA&rft.au=Thompson%2C+MC&rft.au=Gardner%2C+MM&rft.au=Gendler%2C+SJ&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.M011248200&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid1334406-66"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1334406_66-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFGoutDhandPanayotouFry1992" class="citation journal cs1">Gout I, Dhand R, Panayotou G, Fry MJ, Hiles I, Otsu M, et al. (December 1992). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024">"Expression and characterization of the p85 subunit of the phosphatidylinositol 3-kinase complex and a related p85 beta protein by using the baculovirus expression system"</a>. <i>The Biochemical Journal</i>. <b>288</b> (2): <span class="nowrap">395–</span>405. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1042%2Fbj2880395">10.1042/bj2880395</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1132024">1132024</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1334406">1334406</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Biochemical+Journal&rft.atitle=Expression+and+characterization+of+the+p85+subunit+of+the+phosphatidylinositol+3-kinase+complex+and+a+related+p85+beta+protein+by+using+the+baculovirus+expression+system&rft.volume=288&rft.issue=2&rft.pages=%3Cspan+class%3D%22nowrap%22%3E395-%3C%2Fspan%3E405&rft.date=1992-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1132024%23id-name%3DPMC&rft_id=info%3Apmid%2F1334406&rft_id=info%3Adoi%2F10.1042%2Fbj2880395&rft.aulast=Gout&rft.aufirst=I&rft.au=Dhand%2C+R&rft.au=Panayotou%2C+G&rft.au=Fry%2C+MJ&rft.au=Hiles%2C+I&rft.au=Otsu%2C+M&rft.au=Waterfield%2C+MD&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1132024&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid1676673-67"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1676673_67-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFPelesLevyOrUllrich1991" class="citation journal cs1">Peles E, Levy RB, Or E, Ullrich A, Yarden Y (August 1991). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC452891">"Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma"</a>. <i>The EMBO Journal</i>. <b>10</b> (8): <span class="nowrap">2077–</span>2086. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1002%2Fj.1460-2075.1991.tb07739.x">10.1002/j.1460-2075.1991.tb07739.x</a>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC452891">452891</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1676673">1676673</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+EMBO+Journal&rft.atitle=Oncogenic+forms+of+the+neu%2FHER2+tyrosine+kinase+are+permanently+coupled+to+phospholipase+C+gamma&rft.volume=10&rft.issue=8&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2077-%3C%2Fspan%3E2086&rft.date=1991-08&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC452891%23id-name%3DPMC&rft_id=info%3Apmid%2F1676673&rft_id=info%3Adoi%2F10.1002%2Fj.1460-2075.1991.tb07739.x&rft.aulast=Peles&rft.aufirst=E&rft.au=Levy%2C+RB&rft.au=Or%2C+E&rft.au=Ullrich%2C+A&rft.au=Yarden%2C+Y&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC452891&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid1683701-68"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid1683701_68-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFArteagaJohnsonTodderudCoffey1991" class="citation journal cs1">Arteaga CL, Johnson MD, Todderud G, Coffey RJ, Carpenter G, Page DL (December 1991). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52943">"Elevated content of the tyrosine kinase substrate phospholipase C-gamma 1 in primary human breast carcinomas"</a>. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. <b>88</b> (23): <span class="nowrap">10435–</span>10439. <a href="/wiki/Bibcode_(identifier)" class="mw-redirect" title="Bibcode (identifier)">Bibcode</a>:<a rel="nofollow" class="external text" href="https://ui.adsabs.harvard.edu/abs/1991PNAS...8810435A">1991PNAS...8810435A</a>. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1073%2Fpnas.88.23.10435">10.1073/pnas.88.23.10435</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52943">52943</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/1683701">1683701</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America&rft.atitle=Elevated+content+of+the+tyrosine+kinase+substrate+phospholipase+C-gamma+1+in+primary+human+breast+carcinomas&rft.volume=88&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E10435-%3C%2Fspan%3E10439&rft.date=1991-12&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC52943%23id-name%3DPMC&rft_id=info%3Apmid%2F1683701&rft_id=info%3Adoi%2F10.1073%2Fpnas.88.23.10435&rft_id=info%3Abibcode%2F1991PNAS...8810435A&rft.aulast=Arteaga&rft.aufirst=CL&rft.au=Johnson%2C+MD&rft.au=Todderud%2C+G&rft.au=Coffey%2C+RJ&rft.au=Carpenter%2C+G&rft.au=Page%2C+DL&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC52943&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> <li id="cite_note-pmid10085134-69"><span class="mw-cite-backlink"><b><a href="#cite_ref-pmid10085134_69-0">^</a></b></span> <span class="reference-text"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFWongDebThompsonWells1999" class="citation journal cs1">Wong L, Deb TB, Thompson SA, Wells A, Johnson GR (March 1999). <a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.13.8900">"A differential requirement for the COOH-terminal region of the epidermal growth factor (EGF) receptor in amphiregulin and EGF mitogenic signaling"</a>. <i>The Journal of Biological Chemistry</i>. <b>274</b> (13): <span class="nowrap">8900–</span>8909. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.1074%2Fjbc.274.13.8900">10.1074/jbc.274.13.8900</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/10085134">10085134</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=The+Journal+of+Biological+Chemistry&rft.atitle=A+differential+requirement+for+the+COOH-terminal+region+of+the+epidermal+growth+factor+%28EGF%29+receptor+in+amphiregulin+and+EGF+mitogenic+signaling&rft.volume=274&rft.issue=13&rft.pages=%3Cspan+class%3D%22nowrap%22%3E8900-%3C%2Fspan%3E8909&rft.date=1999-03&rft_id=info%3Adoi%2F10.1074%2Fjbc.274.13.8900&rft_id=info%3Apmid%2F10085134&rft.aulast=Wong&rft.aufirst=L&rft.au=Deb%2C+TB&rft.au=Thompson%2C+SA&rft.au=Wells%2C+A&rft.au=Johnson%2C+GR&rft_id=https%3A%2F%2Fdoi.org%2F10.1074%252Fjbc.274.13.8900&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></span> </li> </ol></div></div> <div class="mw-heading mw-heading2"><h2 id="Further_reading">Further reading</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=16" title="Edit section: Further reading"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <style data-mw-deduplicate="TemplateStyles:r1239549316">.mw-parser-output .refbegin{margin-bottom:0.5em}.mw-parser-output .refbegin-hanging-indents>ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}@media screen{.mw-parser-output .refbegin{font-size:90%}}</style><div class="refbegin refbegin-columns references-column-width" style="column-width: 30em"> <ul><li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFZhouHung2003" class="citation journal cs1">Zhou BP, Hung MC (October 2003). "Dysregulation of cellular signaling by HER2/neu in breast cancer". <i>Seminars in Oncology</i>. <b>30</b> (5 Suppl 16): <span class="nowrap">38–</span>48. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1053%2Fj.seminoncol.2003.08.006">10.1053/j.seminoncol.2003.08.006</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/14613025">14613025</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Seminars+in+Oncology&rft.atitle=Dysregulation+of+cellular+signaling+by+HER2%2Fneu+in+breast+cancer&rft.volume=30&rft.issue=5+Suppl+16&rft.pages=%3Cspan+class%3D%22nowrap%22%3E38-%3C%2Fspan%3E48&rft.date=2003-10&rft_id=info%3Adoi%2F10.1053%2Fj.seminoncol.2003.08.006&rft_id=info%3Apmid%2F14613025&rft.aulast=Zhou&rft.aufirst=BP&rft.au=Hung%2C+MC&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFMénardCasaliniCampiglioPupa2004" class="citation journal cs1">Ménard S, Casalini P, Campiglio M, Pupa SM, Tagliabue E (December 2004). "Role of HER2/neu in tumor progression and therapy". <i>Cellular and Molecular Life Sciences</i>. <b>61</b> (23): <span class="nowrap">2965–</span>2978. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1007%2Fs00018-004-4277-7">10.1007/s00018-004-4277-7</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/15583858">15583858</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:37611938">37611938</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cellular+and+Molecular+Life+Sciences&rft.atitle=Role+of+HER2%2Fneu+in+tumor+progression+and+therapy&rft.volume=61&rft.issue=23&rft.pages=%3Cspan+class%3D%22nowrap%22%3E2965-%3C%2Fspan%3E2978&rft.date=2004-12&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A37611938%23id-name%3DS2CID&rft_id=info%3Apmid%2F15583858&rft_id=info%3Adoi%2F10.1007%2Fs00018-004-4277-7&rft.aulast=M%C3%A9nard&rft.aufirst=S&rft.au=Casalini%2C+P&rft.au=Campiglio%2C+M&rft.au=Pupa%2C+SM&rft.au=Tagliabue%2C+E&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBeckerMuller-TidowServeDomschke2006" class="citation journal cs1">Becker JC, Muller-Tidow C, Serve H, Domschke W, Pohle T (June 2006). <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087885">"Role of receptor tyrosine kinases in gastric cancer: new targets for a selective therapy"</a>. <i>World Journal of Gastroenterology</i>. <b>12</b> (21): <span class="nowrap">3297–</span>3305. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.3748%2Fwjg.v12.i21.3297">10.3748/wjg.v12.i21.3297</a></span>. <a href="/wiki/PMC_(identifier)" class="mw-redirect" title="PMC (identifier)">PMC</a> <span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4087885">4087885</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/16733844">16733844</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=World+Journal+of+Gastroenterology&rft.atitle=Role+of+receptor+tyrosine+kinases+in+gastric+cancer%3A+new+targets+for+a+selective+therapy&rft.volume=12&rft.issue=21&rft.pages=%3Cspan+class%3D%22nowrap%22%3E3297-%3C%2Fspan%3E3305&rft.date=2006-06&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4087885%23id-name%3DPMC&rft_id=info%3Apmid%2F16733844&rft_id=info%3Adoi%2F10.3748%2Fwjg.v12.i21.3297&rft.aulast=Becker&rft.aufirst=JC&rft.au=Muller-Tidow%2C+C&rft.au=Serve%2C+H&rft.au=Domschke%2C+W&rft.au=Pohle%2C+T&rft_id=https%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC4087885&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFLaudadioQuigleyTubbsWolff2007" class="citation journal cs1">Laudadio J, Quigley DI, Tubbs R, Wolff DJ (January 2007). "HER2 testing: a review of detection methodologies and their clinical performance". <i>Expert Review of Molecular Diagnostics</i>. <b>7</b> (1): <span class="nowrap">53–</span>64. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<a rel="nofollow" class="external text" href="https://doi.org/10.1586%2F14737159.7.1.53">10.1586/14737159.7.1.53</a>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17187484">17187484</a>. <a href="/wiki/S2CID_(identifier)" class="mw-redirect" title="S2CID (identifier)">S2CID</a> <a rel="nofollow" class="external text" href="https://api.semanticscholar.org/CorpusID:9971746">9971746</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Expert+Review+of+Molecular+Diagnostics&rft.atitle=HER2+testing%3A+a+review+of+detection+methodologies+and+their+clinical+performance&rft.volume=7&rft.issue=1&rft.pages=%3Cspan+class%3D%22nowrap%22%3E53-%3C%2Fspan%3E64&rft.date=2007-01&rft_id=https%3A%2F%2Fapi.semanticscholar.org%2FCorpusID%3A9971746%23id-name%3DS2CID&rft_id=info%3Apmid%2F17187484&rft_id=info%3Adoi%2F10.1586%2F14737159.7.1.53&rft.aulast=Laudadio&rft.aufirst=J&rft.au=Quigley%2C+DI&rft.au=Tubbs%2C+R&rft.au=Wolff%2C+DJ&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></li> <li><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1238218222" /><cite id="CITEREFBianchiTagliabueMénardCampiglio2007" class="citation journal cs1">Bianchi F, Tagliabue E, Ménard S, Campiglio M (March 2007). <a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.6.6.4033">"Fhit expression protects against HER2-driven breast tumor development: unraveling the molecular interconnections"</a>. <i>Cell Cycle</i>. <b>6</b> (6): <span class="nowrap">643–</span>646. <a href="/wiki/Doi_(identifier)" class="mw-redirect" title="Doi (identifier)">doi</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://doi.org/10.4161%2Fcc.6.6.4033">10.4161/cc.6.6.4033</a></span>. <a href="/wiki/Hdl_(identifier)" class="mw-redirect" title="Hdl (identifier)">hdl</a>:<span class="id-lock-free" title="Freely accessible"><a rel="nofollow" class="external text" href="https://hdl.handle.net/2434%2F810034">2434/810034</a></span>. <a href="/wiki/PMID_(identifier)" class="mw-redirect" title="PMID (identifier)">PMID</a> <a rel="nofollow" class="external text" href="https://pubmed.ncbi.nlm.nih.gov/17374991">17374991</a>.</cite><span title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.jtitle=Cell+Cycle&rft.atitle=Fhit+expression+protects+against+HER2-driven+breast+tumor+development%3A+unraveling+the+molecular+interconnections&rft.volume=6&rft.issue=6&rft.pages=%3Cspan+class%3D%22nowrap%22%3E643-%3C%2Fspan%3E646&rft.date=2007-03&rft_id=info%3Ahdl%2F2434%2F810034&rft_id=info%3Apmid%2F17374991&rft_id=info%3Adoi%2F10.4161%2Fcc.6.6.4033&rft.aulast=Bianchi&rft.aufirst=F&rft.au=Tagliabue%2C+E&rft.au=M%C3%A9nard%2C+S&rft.au=Campiglio%2C+M&rft_id=https%3A%2F%2Fdoi.org%2F10.4161%252Fcc.6.6.4033&rfr_id=info%3Asid%2Fen.wikipedia.org%3AHER2" class="Z3988"></span></li></ul> </div> <div class="mw-heading mw-heading2"><h2 id="External_links">External links</h2><span class="mw-editsection"><span class="mw-editsection-bracket">[</span><a href="/w/index.php?title=HER2&action=edit&section=17" title="Edit section: External links"><span>edit</span></a><span class="mw-editsection-bracket">]</span></span></div> <ul><li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20080516045758/http://www.aacr.org/home/public--media/for-the-media/fact-sheets/cancer-concepts/her2.aspx">AACR Cancer Concepts Factsheet on HER2</a></li> <li><a rel="nofollow" class="external text" href="https://web.archive.org/web/20081011055216/http://www.her2.co.za/care/">Breast Friends for Life Network - A South African Breast Cancer Support Forum for HER2 Positive Women</a></li> <li><a rel="nofollow" class="external text" href="http://crdd.osdd.net/raghava/herceptinr/">HerceptinR</a> : Herceptin Resistance Database for Understanding Mechanism of Resistance in Breast Cancer Patients. <a rel="nofollow" class="external text" href="http://www.nature.com/srep/2014/140327/srep04483/full/srep04483.html">Sci. Rep.</a> 4:4483</li> <li><a rel="nofollow" class="external text" href="https://meshb.nlm.nih.gov/record/ui?name=Receptor%2C+erbB-2">Receptor,+erbB-2</a> at the U.S. National Library of Medicine <a href="/wiki/Medical_Subject_Headings" title="Medical Subject Headings">Medical Subject Headings</a> (MeSH)</li> <li><a rel="nofollow" class="external text" href="https://www.ebi.ac.uk/pdbe/pdbe-kb/proteins/P04626">PDBe-KB</a> provides an overview of all the structure information available in the PDB for Human Receptor tyrosine-protein kinase erbB-2</li></ul> <div class="navbox-styles"><style data-mw-deduplicate="TemplateStyles:r1129693374">.mw-parser-output .hlist dl,.mw-parser-output .hlist ol,.mw-parser-output .hlist ul{margin:0;padding:0}.mw-parser-output .hlist dd,.mw-parser-output .hlist dt,.mw-parser-output .hlist li{margin:0;display:inline}.mw-parser-output .hlist.inline,.mw-parser-output .hlist.inline dl,.mw-parser-output .hlist.inline ol,.mw-parser-output .hlist.inline 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Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab" src="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_1n8z_EBI.jpg/250px-PDB_1n8z_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_1n8z_EBI.jpg/330px-PDB_1n8z_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/4/4a/PDB_1n8z_EBI.jpg/500px-PDB_1n8z_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1n8z</b>: Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_1s78_EBI.jpg" class="mw-file-description" title="1s78: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex"><img alt="1s78: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex" src="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1s78_EBI.jpg/180px-PDB_1s78_EBI.jpg" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1s78_EBI.jpg/270px-PDB_1s78_EBI.jpg 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/9/91/PDB_1s78_EBI.jpg/360px-PDB_1s78_EBI.jpg 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>1s78</b>: Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex</div> </li> <li class="gallerybox" style="width: 215px"> <div class="thumb" style="width: 210px; height: 210px;"><span typeof="mw:File"><a href="/wiki/File:PDB_2a91_EBI.png" class="mw-file-description" title="2a91: Crystal structure of ErbB2 domains 1-3"><img alt="2a91: Crystal structure of ErbB2 domains 1-3" src="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PDB_2a91_EBI.png/180px-PDB_2a91_EBI.png" decoding="async" width="180" height="135" class="mw-file-element" srcset="//upload.wikimedia.org/wikipedia/commons/thumb/1/11/PDB_2a91_EBI.png/270px-PDB_2a91_EBI.png 1.5x, //upload.wikimedia.org/wikipedia/commons/thumb/1/11/PDB_2a91_EBI.png/360px-PDB_2a91_EBI.png 2x" data-file-width="800" data-file-height="600" /></a></span></div> <div class="gallerytext"><b>2a91</b>: Crystal structure of ErbB2 domains 1-3</div> </li> </ul></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)188" style="padding:3px"><table class="nowraplinks mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2" style="background:#e7dcc3"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Clusters_of_differentiation" title="Template:Clusters of differentiation"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Clusters_of_differentiation" title="Template talk:Clusters of differentiation"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Clusters_of_differentiation" title="Special:EditPage/Template:Clusters of differentiation"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Proteins:_clusters_of_differentiation_(see_also_list_of_human_clusters_of_differentiation)188" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein" title="Protein">Proteins</a>: <a href="/wiki/Cluster_of_differentiation" title="Cluster of differentiation">clusters of differentiation</a> (see also <a href="/wiki/List_of_human_clusters_of_differentiation" title="List of human clusters of differentiation">list of human clusters of differentiation</a>)</div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">1–50</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD1" title="CD1">CD1</a> <ul><li><a href="/wiki/Group_1_CD1" class="mw-redirect" title="Group 1 CD1">a-c</a></li> <li><a href="/wiki/CD1A" title="CD1A">1A</a></li> <li><a href="/wiki/CD1b" title="CD1b">1B</a></li> <li><a href="/wiki/CD1D" title="CD1D">1D</a></li> <li><a href="/wiki/CD1E" title="CD1E">1E</a></li></ul></li> <li><a href="/wiki/CD2" title="CD2">CD2</a></li> <li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a> <ul><li><a href="/wiki/CD3G" title="CD3G">γ</a></li> <li><a href="/wiki/CD3D" title="CD3D">δ</a></li> <li><a href="/wiki/CD3E" class="mw-redirect" title="CD3E">ε</a></li></ul></li> <li><a href="/wiki/CD4" title="CD4">CD4</a></li> <li><a href="/wiki/CD5_(protein)" title="CD5 (protein)">CD5</a></li> <li><a href="/wiki/CD6" title="CD6">CD6</a></li> <li><a href="/wiki/CD7" title="CD7">CD7</a></li> <li><a href="/wiki/CD8" title="CD8">CD8</a> <ul><li><a href="/wiki/CD8A" title="CD8A">a</a></li></ul></li> <li><a href="/wiki/CD9" title="CD9">CD9</a></li> <li><a href="/wiki/Neprilysin" title="Neprilysin">CD10</a></li> <li><i>CD11</i> <ul><li><a href="/wiki/CD11a" class="mw-redirect" title="CD11a">a</a></li> <li><a href="/wiki/Integrin_alpha_M" title="Integrin alpha M">b</a></li> <li><a href="/wiki/CD11c" class="mw-redirect" title="CD11c">c</a></li> <li><a href="/wiki/ITGAD" class="mw-redirect" title="ITGAD">d</a></li></ul></li> <li><a href="/wiki/Alanine_aminopeptidase" title="Alanine aminopeptidase">CD13</a></li> <li><a href="/wiki/CD14" title="CD14">CD14</a></li> <li><a href="/wiki/CD15" class="mw-redirect" title="CD15">CD15</a></li> <li><a href="/wiki/CD16" title="CD16">CD16</a> <ul><li><a href="/wiki/FCGR3A" title="FCGR3A">A</a></li> <li><a href="/wiki/FCGR3B" title="FCGR3B">B</a></li></ul></li> <li><a href="/wiki/CD18" class="mw-redirect" title="CD18">CD18</a></li> <li><a href="/wiki/CD19" title="CD19">CD19</a></li> <li><a href="/wiki/CD20" title="CD20">CD20</a></li> <li><a href="/wiki/Complement_receptor_2" title="Complement receptor 2">CD21</a></li> <li><a href="/wiki/CD22" title="CD22">CD22</a></li> <li><a href="/wiki/CD23" title="CD23">CD23</a></li> <li><a href="/wiki/CD24" title="CD24">CD24</a></li> <li><a href="/wiki/IL2RA" title="IL2RA">CD25</a></li> <li><a href="/wiki/Dipeptidyl_peptidase-4" title="Dipeptidyl peptidase-4">CD26</a></li> <li><a href="/wiki/CD27" title="CD27">CD27</a></li> <li><a href="/wiki/CD28" title="CD28">CD28</a></li> <li><a href="/wiki/Integrin_beta_1" title="Integrin beta 1">CD29</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/CD31" title="CD31">CD31</a></li> <li><a href="/wiki/CD32" title="CD32">CD32</a> <ul><li><a href="/wiki/FCGR2A" title="FCGR2A">A</a></li> <li><a href="/wiki/FCGR2B" title="FCGR2B">B</a></li></ul></li> <li><a href="/wiki/CD33" title="CD33">CD33</a></li> <li><a href="/wiki/CD34" title="CD34">CD34</a></li> <li><a href="/wiki/Complement_receptor_1" title="Complement receptor 1">CD35</a></li> <li><a href="/wiki/CD36" title="CD36">CD36</a></li> <li><a href="/wiki/CD37" title="CD37">CD37</a></li> <li><a href="/wiki/CD38" title="CD38">CD38</a></li> <li><a href="/wiki/ENTPD1" title="ENTPD1">CD39</a></li> <li><a href="/wiki/CD40_(protein)" title="CD40 (protein)">CD40</a></li> <li><a href="/wiki/ITGA2B" class="mw-redirect" title="ITGA2B">CD41</a></li> <li><a href="/wiki/Glycoprotein_Ib" title="Glycoprotein Ib">CD42</a> <ul><li><a href="/wiki/Glycoprotein_IX" title="Glycoprotein IX">a</a></li> <li><a href="/wiki/GP1BA" title="GP1BA">b</a></li> <li><a href="/wiki/GP1BB" title="GP1BB">c</a></li> <li><a href="/wiki/GP5_(gene)" title="GP5 (gene)">d</a></li></ul></li> <li><a href="/wiki/CD43" title="CD43">CD43</a></li> <li><a href="/wiki/CD44" title="CD44">CD44</a></li> <li><a href="/wiki/PTPRC" title="PTPRC">CD45</a></li> <li><a href="/wiki/CD46" title="CD46">CD46</a></li> <li><a href="/wiki/CD47" title="CD47">CD47</a></li> <li><a href="/wiki/CD48" title="CD48">CD48</a></li> <li><i>CD49</i> <ul><li><a href="/wiki/CD49a" class="mw-redirect" title="CD49a">a</a></li> <li><a href="/wiki/CD49b" class="mw-redirect" title="CD49b">b</a></li> <li><a href="/wiki/CD49c" class="mw-redirect" title="CD49c">c</a></li> <li><a href="/wiki/CD49d" class="mw-redirect" title="CD49d">d</a></li> <li><a href="/wiki/ITGA5" class="mw-redirect" title="ITGA5">e</a></li> <li><a href="/wiki/ITGA6" class="mw-redirect" title="ITGA6">f</a></li></ul></li> <li><a href="/wiki/ICAM3" title="ICAM3">CD50</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">51–100</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ITGAV" class="mw-redirect" title="ITGAV">CD51</a></li> <li><a href="/wiki/CD52" title="CD52">CD52</a></li> <li><a href="/wiki/CD53" title="CD53">CD53</a></li> <li><a href="/wiki/ICAM-1" title="ICAM-1">CD54</a></li> <li><a href="/wiki/Decay-accelerating_factor" title="Decay-accelerating factor">CD55</a></li> <li><a href="/wiki/Neural_cell_adhesion_molecule" title="Neural cell adhesion molecule">CD56</a></li> <li><a href="/wiki/B3GAT1" title="B3GAT1">CD57</a></li> <li><a href="/wiki/CD58" title="CD58">CD58</a></li> <li><a href="/wiki/CD59" title="CD59">CD59</a></li> <li><a href="/wiki/CD61" class="mw-redirect" title="CD61">CD61</a></li> <li><a href="/wiki/Selectin" title="Selectin">CD62</a> <ul><li><a href="/wiki/E-selectin" title="E-selectin">E</a></li> <li><a href="/wiki/L-selectin" title="L-selectin">L</a></li> <li><a href="/wiki/P-selectin" title="P-selectin">P</a></li></ul></li> <li><a href="/wiki/CD63" title="CD63">CD63</a></li> <li><a href="/wiki/CD64_(biology)" title="CD64 (biology)">CD64</a> <ul><li><a href="/wiki/FCGR1A" title="FCGR1A">A</a></li> <li><a href="/wiki/FCGR1B" class="mw-redirect" title="FCGR1B">B</a></li> <li><a href="/wiki/FCGR1C" class="mw-redirect" title="FCGR1C">C</a></li></ul></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">CD66</a> <ul><li><a href="/wiki/CEACAM1" title="CEACAM1">a</a></li> <li><a href="/wiki/CEACAM8" title="CEACAM8">b</a></li> <li><a href="/wiki/CEACAM6" title="CEACAM6">c</a></li> <li><a href="/wiki/CEACAM3" title="CEACAM3">d</a></li> <li><a href="/wiki/CEACAM5" title="CEACAM5">e</a></li> <li><a href="/wiki/PSG1_(gene)" class="mw-redirect" title="PSG1 (gene)">f</a></li></ul></li> <li><a href="/wiki/CD68" title="CD68">CD68</a></li> <li><a href="/wiki/CD69" title="CD69">CD69</a></li> <li><a href="/wiki/CD70" title="CD70">CD70</a></li> <li><a href="/wiki/TFRC" class="mw-redirect" title="TFRC">CD71</a></li> <li><a href="/wiki/CD72" title="CD72">CD72</a></li> <li><a href="/wiki/NT5E" title="NT5E">CD73</a></li> <li><a href="/wiki/CD74" title="CD74">CD74</a></li> <li><a href="/wiki/CD78" title="CD78">CD78</a></li> <li><a href="/wiki/CD79" title="CD79">CD79</a> <ul><li><a href="/wiki/CD79A" title="CD79A">a</a></li> <li><a href="/wiki/CD79B" title="CD79B">b</a></li></ul></li> <li><a href="/wiki/CD80" title="CD80">CD80</a></li> <li><a href="/wiki/CD81" title="CD81">CD81</a></li> <li><a href="/wiki/CD82_(gene)" title="CD82 (gene)">CD82</a></li> <li><a href="/wiki/CD83" title="CD83">CD83</a></li> <li><a href="/wiki/CD84" title="CD84">CD84</a></li> <li><i>CD85</i> <ul><li><a href="/wiki/LILRB3" title="LILRB3">a</a></li> <li><a href="/wiki/LILRB2" title="LILRB2">d</a></li> <li><a href="/wiki/LILRA3" title="LILRA3">e</a></li> <li><a href="/wiki/LILRA2" title="LILRA2">h</a></li> <li><a href="/wiki/LILRB1" title="LILRB1">j</a></li> <li><a href="/wiki/LILRB4" title="LILRB4">k</a></li></ul></li> <li><a href="/wiki/CD86" title="CD86">CD86</a></li> <li><a href="/wiki/Urokinase_receptor" title="Urokinase receptor">CD87</a></li> <li><a href="/wiki/C5a_receptor" title="C5a receptor">CD88</a></li> <li><a href="/wiki/FCAR" title="FCAR">CD89</a></li> <li><a href="/wiki/CD90" title="CD90">CD90</a></li> <li><a href="/wiki/LRP1" title="LRP1">CD91</a> - <a href="/wiki/SLC44A1" class="mw-redirect" title="SLC44A1">CD92</a></li> <li><a href="/wiki/CD93" title="CD93">CD93</a></li> <li><a href="/wiki/KLRD1" title="KLRD1">CD94</a></li> <li><a href="/wiki/Fas_receptor" title="Fas receptor">CD95</a></li> <li><a href="/wiki/CD96" title="CD96">CD96</a></li> <li><a href="/wiki/CD97" title="CD97">CD97</a></li> <li><a href="/wiki/CD98" title="CD98">CD98</a></li> <li><a href="/wiki/CD99" title="CD99">CD99</a></li> <li><a href="/wiki/SEMA4D" title="SEMA4D">CD100</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">101–150</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/IGSF2" title="IGSF2">CD101</a></li> <li><a href="/wiki/ICAM2" title="ICAM2">CD102</a></li> <li><a href="/wiki/ITGAE" title="ITGAE">CD103</a></li> <li><a href="/wiki/ITGB4" class="mw-redirect" title="ITGB4">CD104</a></li> <li><a href="/wiki/Endoglin" title="Endoglin">CD105</a></li> <li><a href="/wiki/VCAM-1" title="VCAM-1">CD106</a></li> <li><i>CD107</i> <ul><li><a href="/wiki/LAMP1" title="LAMP1">a</a></li> <li><a href="/wiki/LAMP2" title="LAMP2">b</a></li></ul></li> <li><a href="/wiki/SEMA7A" title="SEMA7A">CD108</a></li> <li><a href="/wiki/CD109" title="CD109">CD109</a></li> <li><a href="/wiki/Myeloproliferative_leukemia_virus_oncogene" class="mw-redirect" title="Myeloproliferative leukemia virus oncogene">CD110</a></li> <li><a href="/wiki/PVRL1" class="mw-redirect" title="PVRL1">CD111</a></li> <li><a href="/wiki/PVRL2" class="mw-redirect" title="PVRL2">CD112</a></li> <li><a href="/wiki/PVRL3" class="mw-redirect" title="PVRL3">CD113</a></li> <li><a href="/wiki/Granulocyte_colony-stimulating_factor_receptor" title="Granulocyte colony-stimulating factor receptor">CD114</a></li> <li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CD115</a></li> <li><a href="/wiki/Granulocyte_macrophage_colony-stimulating_factor_receptor" class="mw-redirect" title="Granulocyte macrophage colony-stimulating factor receptor">CD116</a></li> <li><a href="/wiki/KIT_(gene)" title="KIT (gene)">CD117</a></li> <li><a href="/wiki/Leukemia_inhibitory_factor_receptor" title="Leukemia inhibitory factor receptor">CD118</a></li> <li><a href="/wiki/Interferon_gamma_receptor_1" title="Interferon gamma receptor 1">CD119</a></li> <li><a href="/wiki/CD120" title="CD120">CD120</a> <ul><li><a href="/wiki/TNFRSF1A" class="mw-redirect" title="TNFRSF1A">a</a></li> <li><a href="/wiki/TNFRSF1B" class="mw-redirect" title="TNFRSF1B">b</a></li></ul></li> <li><i>CD121</i> <ul><li><a href="/wiki/Interleukin_1_receptor,_type_I" title="Interleukin 1 receptor, type I">a</a></li> <li><a href="/wiki/Interleukin_1_receptor,_type_II" title="Interleukin 1 receptor, type II">b</a></li></ul></li> <li><a href="/wiki/IL2RB" title="IL2RB">CD122</a></li> <li><a href="/wiki/IL3RA" title="IL3RA">CD123</a></li> <li><a href="/wiki/Interleukin-4_receptor" title="Interleukin-4 receptor">CD124</a></li> <li><a href="/wiki/Interleukin_5_receptor_alpha_subunit" title="Interleukin 5 receptor alpha subunit">CD125</a></li> <li><a href="/wiki/Interleukin-6_receptor" title="Interleukin-6 receptor">CD126</a></li> <li><a href="/wiki/Interleukin-7_receptor" title="Interleukin-7 receptor">CD127</a></li> <li><a href="/wiki/Interleukin-9_receptor" title="Interleukin-9 receptor">CD129</a></li> <li><a href="/wiki/Glycoprotein_130" title="Glycoprotein 130">CD130</a></li> <li><a href="/wiki/CSF2RB" title="CSF2RB">CD131</a></li> <li><a href="/wiki/Common_gamma_chain" title="Common gamma chain">CD132</a></li> <li><a href="/wiki/CD133" title="CD133">CD133</a></li> <li><a href="/wiki/CD134" title="CD134">CD134</a></li> <li><a href="/wiki/CD135" title="CD135">CD135</a></li> <li><a href="/wiki/MST1R" title="MST1R">CD136</a></li> <li><a href="/wiki/CD137" title="CD137">CD137</a></li> <li><a href="/wiki/Syndecan_1" title="Syndecan 1">CD138</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">CD140b</a></li> <li><a href="/wiki/Thrombomodulin" title="Thrombomodulin">CD141</a></li> <li><a href="/wiki/Tissue_factor" title="Tissue factor">CD142</a></li> <li><a href="/wiki/Angiotensin-converting_enzyme" title="Angiotensin-converting enzyme">CD143</a></li> <li><a href="/wiki/VE-cadherin" title="VE-cadherin">CD144</a></li> <li><a href="/wiki/CD146" title="CD146">CD146</a></li> <li><a href="/wiki/Basigin" title="Basigin">CD147</a></li> <li><a href="/wiki/PTPRJ" title="PTPRJ">CD148</a></li> <li><a href="/wiki/SLAMF1" title="SLAMF1">CD150</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">151–200</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD151" title="CD151">CD151</a></li> <li><a href="/wiki/CTLA-4" class="mw-redirect" title="CTLA-4">CD152</a></li> <li><a href="/wiki/CD153" title="CD153">CD153</a></li> <li><a href="/wiki/CD154" title="CD154">CD154</a></li> <li><a href="/wiki/CD155" title="CD155">CD155</a></li> <li><i>CD156</i> <ul><li><a href="/wiki/ADAM8" title="ADAM8">a</a></li> <li><a href="/wiki/ADAM17" title="ADAM17">b</a></li> <li><a href="/wiki/ADAM10" title="ADAM10">c</a></li></ul></li> <li><a href="/wiki/BST1" title="BST1">CD157</a></li> <li><i>CD158</i> (<a href="/wiki/KIR2DL1" title="KIR2DL1">a</a></li> <li><a href="/wiki/KIR2DL4" title="KIR2DL4">d</a></li> <li><a href="/wiki/KIR3DL1" title="KIR3DL1">e</a></li> <li><a href="/wiki/KIR2DS4" title="KIR2DS4">i</a></li> <li><a href="/wiki/KIR3DL2" title="KIR3DL2">k</a>)</li> <li><i>CD159</i> <ul><li><a href="/wiki/NKG2" title="NKG2">a</a></li> <li><a href="/wiki/KLRC2" title="KLRC2">c</a></li></ul></li> <li><a href="/wiki/CD160" title="CD160">CD160</a></li> <li><a href="/wiki/KLRB1" title="KLRB1">CD161</a></li> <li><a href="/wiki/P-selectin_glycoprotein_ligand-1" title="P-selectin glycoprotein ligand-1">CD162</a></li> <li><a href="/wiki/CD163" title="CD163">CD163</a></li> <li><a href="/wiki/CD164" title="CD164">CD164</a></li> <li><a href="/wiki/ALCAM" title="ALCAM">CD166</a></li> <li><i>CD167</i> <ul><li><a href="/wiki/DDR1" title="DDR1">a</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">b</a></li></ul></li> <li><a href="/wiki/Hyaluronan-mediated_motility_receptor" title="Hyaluronan-mediated motility receptor">CD168</a></li> <li><a href="/wiki/Sialoadhesin" title="Sialoadhesin">CD169</a></li> <li><a href="/wiki/SIGLEC5" title="SIGLEC5">CD170</a></li> <li><a href="/wiki/L1_(protein)" title="L1 (protein)">CD171</a></li> <li><i>CD172</i> <ul><li><a href="/wiki/Signal-regulatory_protein_alpha" title="Signal-regulatory protein alpha">a</a></li> <li><a href="/wiki/SIRPB1" title="SIRPB1">b</a></li> <li><a href="/wiki/SIRPG" title="SIRPG">g</a></li></ul></li> <li><a href="/wiki/Fucosyltransferase_3" title="Fucosyltransferase 3">CD174</a></li> <li><a href="/wiki/CD177" title="CD177">CD177</a></li> <li><a href="/wiki/Fas_ligand" title="Fas ligand">CD178</a></li> <li><i>CD179</i> <ul><li><a href="/wiki/VPREB1" title="VPREB1">a</a></li> <li><a href="/wiki/IGLL1" title="IGLL1">b</a></li></ul></li> <li><a href="/wiki/CD180" title="CD180">CD180</a></li> <li><a href="/wiki/Interleukin_8_receptor,_alpha" title="Interleukin 8 receptor, alpha">CD181</a></li> <li><a href="/wiki/Interleukin_8_receptor,_beta" title="Interleukin 8 receptor, beta">CD182</a></li> <li><a href="/wiki/CXCR3" title="CXCR3">CD183</a></li> <li><a href="/wiki/CXCR4" title="CXCR4">CD184</a></li> <li><a href="/wiki/CXCR5" title="CXCR5">CD185</a></li> <li><a href="/wiki/CXCR6" title="CXCR6">CD186</a></li> <li><a href="/wiki/CCR1" title="CCR1">CD191</a></li> <li><a href="/wiki/CCR2" title="CCR2">CD192</a></li> <li><a href="/wiki/CCR3_(gene)" title="CCR3 (gene)">CD193</a></li> <li><a href="/wiki/CCR4" title="CCR4">CD194</a></li> <li><a href="/wiki/CCR5" title="CCR5">CD195</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_6" title="C-C chemokine receptor type 6">CD196</a></li> <li><a href="/wiki/C-C_chemokine_receptor_type_7" title="C-C chemokine receptor type 7">CD197</a></li> <li><a href="/wiki/CCR8_(gene)" title="CCR8 (gene)">CDw198</a></li> <li><a href="/wiki/CCR9" title="CCR9">CDw199</a></li> <li><a href="/wiki/CD200" title="CD200">CD200</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">201–250</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Endothelial_protein_C_receptor" title="Endothelial protein C receptor">CD201</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">CD202b</a></li> <li><a href="/wiki/MSR1" title="MSR1">CD204</a></li> <li><a href="/wiki/LY75" class="mw-redirect" title="LY75">CD205</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD206</a></li> <li><a href="/wiki/CD207" class="mw-redirect" title="CD207">CD207</a></li> <li><a href="/wiki/LAMP3" title="LAMP3">CD208</a></li> <li><a href="/wiki/DC-SIGN" title="DC-SIGN">CD209</a></li> <li><i>CDw210</i> <ul><li><a href="/wiki/Interleukin_10_receptor,_alpha_subunit" title="Interleukin 10 receptor, alpha subunit">a</a></li> <li><a href="/wiki/Interleukin_10_receptor,_beta_subunit" title="Interleukin 10 receptor, beta subunit">b</a></li></ul></li> <li><a href="/wiki/Interleukin_12_receptor,_beta_1_subunit" title="Interleukin 12 receptor, beta 1 subunit">CD212</a></li> <li><i>CD213a</i> <ul><li><a href="/wiki/IL13RA1" class="mw-redirect" title="IL13RA1">1</a></li> <li><a href="/wiki/IL13RA2" title="IL13RA2">2</a></li></ul></li> <li><a href="/wiki/IL17RA" title="IL17RA">CD217</a></li> <li><i>CD218</i> (<a href="/wiki/IL18R1" title="IL18R1">a</a></li> <li><a href="/wiki/IL18RAP" title="IL18RAP">b</a>)</li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">CD220</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">CD221</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">CD222</a></li> <li><a href="/wiki/LAG3" class="mw-redirect" title="LAG3">CD223</a></li> <li><a href="/wiki/GGT1" class="mw-redirect" title="GGT1">CD224</a></li> <li><a href="/wiki/IFITM1" title="IFITM1">CD225</a></li> <li><a href="/wiki/CD226" title="CD226">CD226</a></li> <li><a href="/wiki/MUC1" class="mw-redirect" title="MUC1">CD227</a></li> <li><a href="/wiki/MFI2" class="mw-redirect" title="MFI2">CD228</a></li> <li><a href="/wiki/LY9" title="LY9">CD229</a></li> <li><a href="/wiki/PRNP" class="mw-redirect" title="PRNP">CD230</a></li> <li><a href="/wiki/Band_3" class="mw-redirect" title="Band 3">CD233</a></li> <li><a href="/wiki/Duffy_antigen_system" title="Duffy antigen system">CD234</a></li> <li><i>CD235</i> <ul><li><a href="/wiki/GYPA" class="mw-redirect" title="GYPA">a</a></li> <li><a href="/wiki/GYPB" title="GYPB">b</a></li></ul></li> <li><a href="/wiki/Glycophorin_C" title="Glycophorin C">CD236</a></li> <li><a href="/wiki/Kell_antigen_system" title="Kell antigen system">CD238</a></li> <li><a href="/wiki/Basal_cell_adhesion_molecule" title="Basal cell adhesion molecule">CD239</a></li> <li><a href="/wiki/RHCE_(gene)" title="RHCE (gene)">CD240CE</a></li> <li><a href="/wiki/RHD_(gene)" title="RHD (gene)">CD240D</a></li> <li><a href="/wiki/RHAG" title="RHAG">CD241</a></li> <li><a href="/wiki/P-glycoprotein" title="P-glycoprotein">CD243</a></li> <li><a href="/wiki/CD244" title="CD244">CD244</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">CD246</a></li> <li><a href="/wiki/CD247" class="mw-redirect" title="CD247">CD247</a> - <a href="/wiki/CD248" title="CD248">CD248</a></li> <li><a href="/wiki/Glutamyl_aminopeptidase" title="Glutamyl aminopeptidase">CD249</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">251–300</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/OX40L" class="mw-redirect" title="OX40L"> CD252</a></li> <li><a href="/wiki/TRAIL" title="TRAIL">CD253</a></li> <li><a href="/wiki/RANKL" title="RANKL">CD254</a></li> <li><a href="/wiki/TNFSF13" class="mw-redirect" title="TNFSF13">CD256</a></li> <li><a href="/wiki/B-cell_activating_factor" title="B-cell activating factor">CD257</a></li> <li><a href="/wiki/TNFSF14" class="mw-redirect" title="TNFSF14">CD258</a></li> <li><a href="/wiki/TNFRSF10A" class="mw-redirect" title="TNFRSF10A">CD261</a></li> <li><a href="/wiki/TNFRSF10B" class="mw-redirect" title="TNFRSF10B">CD262</a></li> <li><a href="/wiki/TNFRSF10C" class="mw-redirect" title="TNFRSF10C">CD263</a></li> <li><a href="/wiki/TNFRSF10D" class="mw-redirect" title="TNFRSF10D">CD264</a></li> <li><a href="/wiki/RANK" title="RANK">CD265</a></li> <li><a href="/wiki/TNFRSF12A" title="TNFRSF12A">CD266</a></li> <li><a href="/wiki/TNFRSF13B" class="mw-redirect" title="TNFRSF13B">CD267</a></li> <li><a href="/wiki/TNFRSF13C" class="mw-redirect" title="TNFRSF13C">CD268</a></li> <li><a href="/wiki/TNFRSF17" class="mw-redirect" title="TNFRSF17">CD269</a></li> <li><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">CD271</a></li> <li><a href="/wiki/BTLA" title="BTLA">CD272</a></li> <li><a href="/wiki/PDCD1LG2" title="PDCD1LG2">CD273</a></li> <li><a href="/wiki/CD274" class="mw-redirect" title="CD274">CD274</a></li> <li><a href="/wiki/ICOSLG" title="ICOSLG">CD275</a></li> <li><a href="/wiki/CD276" title="CD276">CD276</a></li> <li><a href="/wiki/CD278" title="CD278">CD278</a></li> <li><a href="/wiki/Programmed_cell_death_protein_1" title="Programmed cell death protein 1">CD279</a></li> <li><a href="/wiki/Mannose_receptor" title="Mannose receptor">CD280</a></li> <li><a href="/wiki/TLR_1" class="mw-redirect" title="TLR 1">CD281</a></li> <li><a href="/wiki/TLR2" class="mw-redirect" title="TLR2">CD282</a></li> <li><a href="/wiki/TLR3" class="mw-redirect" title="TLR3">CD283</a></li> <li><a href="/wiki/TLR4" class="mw-redirect" title="TLR4">CD284</a></li> <li><a href="/wiki/TLR6" class="mw-redirect" title="TLR6">CD286</a></li> <li><a href="/wiki/TLR8" class="mw-redirect" title="TLR8">CD288</a></li> <li><a href="/wiki/TLR9" class="mw-redirect" title="TLR9">CD289</a></li> <li><a href="/wiki/TLR10" class="mw-redirect" title="TLR10">CD290</a></li> <li><a href="/wiki/BMPR1A" title="BMPR1A">CD292</a></li> <li><a href="/wiki/BMPR1B" title="BMPR1B">CDw293</a></li> <li><a href="/wiki/CD294" class="mw-redirect" title="CD294">CD294</a></li> <li><a href="/wiki/Leptin_receptor" title="Leptin receptor">CD295</a></li> <li><a href="/wiki/ART4" title="ART4">CD297</a></li> <li><a href="/wiki/ATP1B3" title="ATP1B3">CD298</a></li> <li><a href="/wiki/CLEC4M" title="CLEC4M">CD299</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;background-color: AntiqueWhite">301–350</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD300A" title="CD300A">CD300A</a></li> <li><a href="/wiki/CLEC10A" title="CLEC10A">CD301</a></li> <li><a href="/wiki/CD302" title="CD302">CD302</a></li> <li><a href="/wiki/CLEC4C" title="CLEC4C">CD303</a></li> <li><a href="/wiki/Neuropilin" title="Neuropilin">CD304</a></li> <li><a href="/wiki/LAIR1" title="LAIR1">CD305</a></li> <li><a href="/wiki/LAIR2" title="LAIR2">CD306</a></li> <li><a href="/wiki/FCRL5" title="FCRL5">CD307</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">CD309</a></li> <li><a href="/wiki/EMR2" title="EMR2">CD312</a></li> <li><a href="/wiki/NKG2D" title="NKG2D">CD314</a></li> <li><a href="/wiki/PTGFRN" title="PTGFRN">CD315</a></li> <li><a href="/wiki/IGSF8" title="IGSF8">CD316</a></li> <li><a href="/wiki/Tetherin" title="Tetherin">CD317</a></li> <li><a href="/wiki/CDCP1" title="CDCP1">CD318</a></li> <li><a href="/wiki/CD320" title="CD320">CD320</a></li> <li><a href="/wiki/F11_receptor" title="F11 receptor">CD321</a></li> <li><a href="/wiki/JAM2" title="JAM2">CD322</a></li> <li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CD324</a></li> <li><a href="/wiki/CDH2" class="mw-redirect" title="CDH2">CD325</a></li> <li><a href="/wiki/Epithelial_cell_adhesion_molecule" title="Epithelial cell adhesion molecule">CD326</a></li> <li><a href="/wiki/SIGLEC6" title="SIGLEC6">CD327</a></li> <li><a href="/wiki/SIGLEC7" title="SIGLEC7">CD328</a></li> <li><a href="/wiki/SIGLEC9" title="SIGLEC9">CD329</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">CD331</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">CD332</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">CD333</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">CD334</a></li> <li><a href="/wiki/NCR1" title="NCR1">CD335</a></li> <li><a href="/wiki/NCR2" title="NCR2">CD336</a></li> <li><a href="/wiki/NCR3" title="NCR3">CD337</a></li> <li><a href="/wiki/ABCG2" title="ABCG2">CD338</a></li> <li><a href="/wiki/JAG1" title="JAG1">CD339</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">CD340</a></li> <li><a href="/wiki/FZD4" class="mw-redirect" title="FZD4">CD344</a></li> <li><a href="/wiki/FZD9" class="mw-redirect" title="FZD9">CD349</a></li> <li><a href="/wiki/FZD10" class="mw-redirect" title="FZD10">CD350</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Tumor_suppressor_genes_and_Oncogenes246" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Tumor_suppressor_genes_and_oncogenes" title="Template:Tumor suppressor genes and oncogenes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Tumor_suppressor_genes_and_oncogenes" title="Template talk:Tumor suppressor genes and oncogenes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Tumor_suppressor_genes_and_oncogenes" title="Special:EditPage/Template:Tumor suppressor genes and oncogenes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Tumor_suppressor_genes_and_Oncogenes246" style="font-size:114%;margin:0 4em"><a href="/wiki/Tumor_suppressor_gene" title="Tumor suppressor gene">Tumor suppressor genes</a> and <a href="/wiki/Oncogene" title="Oncogene">Oncogenes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ligand_(biochemistry)" title="Ligand (biochemistry)">Ligand</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Growth_factors18" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Growth_factor" title="Growth factor">Growth factors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="ONCO4" scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">c-Sis/PDGF</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">HGF</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_(biochemistry)" title="Receptor (biochemistry)">Receptor</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CDH1_(gene)" class="mw-redirect" title="CDH1 (gene)">CDH1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hedgehog_signaling_pathway" title="Hedgehog signaling pathway">Hedgehog signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTCH1" title="PTCH1">PTCH1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TGF_beta_signaling_pathway" title="TGF beta signaling pathway">TGF beta signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TGF_beta_receptor_2" title="TGF beta receptor 2">TGF beta receptor 2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="ONCO4" scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ErbB" title="ErbB">ErbB</a>/<a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">c-ErbB</a> <ul><li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">HER2/neu</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">Her 3</a></li></ul></li> <li><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">c-Met</a></li> <li><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">c-Ret</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/JAK-STAT_signaling_pathway" title="JAK-STAT signaling pathway">JAK-STAT signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="ONCO4" scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD117" class="mw-redirect" title="CD117">c-Kit</a></li> <li><a href="/wiki/CD135" title="CD135">Flt3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Intracellular_signaling_peptides_and_proteins" class="mw-redirect" title="Intracellular signaling peptides and proteins">Intracellular signaling P+Ps</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Beta-catenin" class="mw-redirect" title="Beta-catenin">Beta-catenin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Adenomatosis_polyposis_coli" class="mw-redirect" title="Adenomatosis polyposis coli">APC</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TGF_beta_signaling_pathway" title="TGF beta signaling pathway">TGF beta signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Mothers_against_decapentaplegic_homolog_2" title="Mothers against decapentaplegic homolog 2">SMAD2</a></li> <li><a href="/wiki/Mothers_against_decapentaplegic_homolog_4" title="Mothers against decapentaplegic homolog 4">SMAD4</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Akt/PKB_signaling_pathway" title="Akt/PKB signaling pathway">Akt/PKB signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AKT" class="mw-redirect" title="AKT">c-Akt</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTEN_(gene)" title="PTEN (gene)">PTEN</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hippo_signaling_pathway" title="Hippo signaling pathway">Hippo signaling pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Merlin_(protein)" title="Merlin (protein)">Neurofibromin 2/Merlin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MAPK/ERK_pathway" title="MAPK/ERK pathway">MAPK/ERK pathway</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Ras_(protein)" class="mw-redirect" title="Ras (protein)">c-Ras</a></li> <li><a href="/wiki/HRAS" title="HRAS">HRAS</a></li> <li><a href="/wiki/C-Raf" title="C-Raf">c-Raf</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neurofibromin" title="Neurofibromin">Neurofibromin 1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/unknown</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proto-oncogene_tyrosine-protein_kinase_Src" title="Proto-oncogene tyrosine-protein kinase Src">c-Src</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Maspin" title="Maspin">Maspin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_nucleus" title="Cell nucleus">Nucleus</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Cell_cycle" title="Cell cycle">Cell cycle</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cyclin-dependent_kinase_4" title="Cyclin-dependent kinase 4">CDK4</a></li> <li><a href="/wiki/Cyclin_D" title="Cyclin D">Cyclin D</a></li> <li><a href="/wiki/Cyclin_E" title="Cyclin E">Cyclin E</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/P53" title="P53">p53</a></li> <li><a href="/wiki/Retinoblastoma_protein" title="Retinoblastoma protein">pRb</a></li> <li><a href="/wiki/WT1" class="mw-redirect" title="WT1">WT1</a></li> <li><a href="/wiki/P16_(gene)" class="mw-redirect" title="P16 (gene)">p16</a>/<a href="/wiki/P14arf" title="P14arf">p14arf</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DNA_repair" title="DNA repair">DNA repair</a>/<a href="/wiki/Fanconi_anemia" title="Fanconi anemia">Fanconi</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="TSP3" scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/BRCA1" title="BRCA1">BRCA1</a></li> <li><a href="/wiki/BRCA2" title="BRCA2">BRCA2</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ubiquitin_ligase" title="Ubiquitin ligase">Ubiquitin ligase</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CBL_(gene)" title="CBL (gene)">CBL</a></li> <li><a href="/wiki/Mdm2" title="Mdm2">MDM2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Von_Hippel%E2%80%93Lindau_tumor_suppressor" title="Von Hippel–Lindau tumor suppressor">VHL</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Transcription_factor" title="Transcription factor">Transcription factor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%">ONCO</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AP-1_transcription_factor" title="AP-1 transcription factor">AP-1</a> <ul><li><a href="/wiki/C-Fos" class="mw-redirect" title="C-Fos">c-Fos</a></li> <li><a href="/wiki/C-jun" class="mw-redirect" title="C-jun">c-Jun</a></li></ul></li> <li><a href="/wiki/Myc" title="Myc">c-Myc</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">TSP</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/KLF6" title="KLF6">KLF6</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Mitochondrion" title="Mitochondrion">Mitochondrion</a></th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Apoptosis_inhibitor46" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Inhibitor_of_apoptosis" title="Inhibitor of apoptosis">Apoptosis inhibitor</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/SDHB" title="SDHB">SDHB</a></li> <li><a href="/wiki/SDHD" title="SDHD">SDHD</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Other/ungrouped</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Bcl-2" title="Bcl-2">c-Bcl-2</a></li> <li><a href="/wiki/Notch_signaling" class="mw-redirect" title="Notch signaling">Notch</a></li> <li><a href="/wiki/Stathmin" title="Stathmin">Stathmin</a></li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Tumor_markers157" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Tumor_markers" title="Template:Tumor markers"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Tumor_markers" title="Template talk:Tumor markers"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Tumor_markers" title="Special:EditPage/Template:Tumor markers"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Tumor_markers157" style="font-size:114%;margin:0 4em"><a href="/wiki/Tumor_marker" title="Tumor marker">Tumor markers</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Blood</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lymphoma" title="Lymphoma">Lymphoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Neprilysin" title="Neprilysin">Neprilysin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lymphosarcoma" class="mw-redirect" title="Lymphosarcoma">Lymphosarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CD3_(immunology)" title="CD3 (immunology)">CD3</a></li> <li><a href="/wiki/CD79A" title="CD79A">CD79a</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Endocrine</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Thyroid_cancer" title="Thyroid cancer">Thyroid cancer</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Thyroglobulin" title="Thyroglobulin">Thyroglobulin</a></li> <li><a href="/wiki/Medullary_thyroid_cancer" title="Medullary thyroid cancer">Medullary thyroid cancer</a> (<a href="/wiki/Calcitonin" title="Calcitonin">Calcitonin</a></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pheochromocytoma" title="Pheochromocytoma">Pheochromocytoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Normetanephrine" title="Normetanephrine">Normetanephrine</a></li> <li><a href="/wiki/Enolase_2" title="Enolase 2">Enolase 2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neuroendocrine_tumor" title="Neuroendocrine tumor">Neuroendocrine tumors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Synaptophysin" title="Synaptophysin">Synaptophysin</a></li> <li><a href="/wiki/Chromogranin_A" class="mw-redirect" title="Chromogranin A">Chromogranin A</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neuroblastoma" title="Neuroblastoma">Neuroblastoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Homovanillic_acid" title="Homovanillic acid">Homovanillic acid</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Nervous system</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Brain_tumor" title="Brain tumor">Brain tumor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proliferating_cell_nuclear_antigen" title="Proliferating cell nuclear antigen">PCNA</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Astrocytoma" title="Astrocytoma">Astrocytoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Glial_fibrillary_acidic_protein" title="Glial fibrillary acidic protein">Glial fibrillary acidic protein</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Neural_crest" title="Neural crest">NC</a>/<a href="/wiki/Melanoma" title="Melanoma">Melanoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/S100_protein" title="S100 protein">S100 protein</a></li> <li><a href="/wiki/Melanoma_inhibitory_activity" title="Melanoma inhibitory activity">Melanoma inhibitory activity</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Cardiovascular/<br />respiratory</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Lung_cancer" title="Lung cancer">Lung cancer</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/Enolase_2" title="Enolase 2">Enolase 2</a></li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Autocrine motility factor</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hemangiosarcoma" title="Hemangiosarcoma">Hemangiosarcoma</a> (<a href="/wiki/Endothelium" title="Endothelium">endothelium</a>)</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Factor_VIII" title="Factor VIII">Factor VIII</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Digestive</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Colorectal_cancer" title="Colorectal cancer">Colorectal cancer</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CA19-9" title="CA19-9">CA19-9</a></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Pancreatic_cancer" title="Pancreatic cancer">Pancreatic cancer</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CA19-9" title="CA19-9">CA19-9</a></li> <li><a href="/wiki/Carcinoembryonic_antigen" title="Carcinoembryonic antigen">Carcinoembryonic antigen</a></li> <li><a href="/wiki/CA_242_(tumor_marker)" title="CA 242 (tumor marker)">CA 242</a></li> <li><a href="/wiki/Tumor-associated_glycoprotein_72" title="Tumor-associated glycoprotein 72">Tumor-associated glycoprotein 72</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Hepatocellular_carcinoma" title="Hepatocellular carcinoma">Hepatocellular carcinoma</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Alpha-fetoprotein" title="Alpha-fetoprotein">Alpha-fetoprotein</a>/<a href="/wiki/AFP-L3" title="AFP-L3">AFP-L3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Reproductive/<br />urinary/<br />breast</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ovarian_cancer" title="Ovarian cancer">Ovarian tumor</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i><a href="/wiki/Surface_epithelial-stromal_tumor" title="Surface epithelial-stromal tumor">Surface epithelial-stromal tumor</a></i> <ul><li><a href="/wiki/CA-125" class="mw-redirect" title="CA-125">CA-125</a></li></ul></li> <li><i><a href="/wiki/Embryonal_carcinoma" title="Embryonal carcinoma">EC</a></i> <ul><li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/Human_chorionic_gonadotropin" title="Human chorionic gonadotropin">hCG</a></li></ul></li> <li><i><a href="/wiki/Endodermal_sinus_tumor" title="Endodermal sinus tumor">EST</a></i> <ul><li><a href="/wiki/Alpha-fetoprotein" title="Alpha-fetoprotein">Alpha-fetoprotein</a></li></ul></li> <li><i><a href="/wiki/Choriocarcinoma" title="Choriocarcinoma">Choriocarcinoma</a></i> <ul><li><a href="/wiki/Human_chorionic_gonadotropin" title="Human chorionic gonadotropin">hCG</a></li></ul></li> <li><i><a href="/wiki/Dysgerminoma" title="Dysgerminoma">Dysgerminoma</a></i> <ul><li><a href="/wiki/Lactate_dehydrogenase" title="Lactate dehydrogenase">LDH</a></li></ul></li> <li><i><a href="/wiki/Sertoli%E2%80%93Leydig_cell_tumour" title="Sertoli–Leydig cell tumour">Sertoli–Leydig cell tumour</a></i> <ul><li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul></li> <li><i><a href="/wiki/Germ_cell_tumor" title="Germ cell tumor">GCT</a></i> <ul><li><a href="/wiki/Inhibin" class="mw-redirect" title="Inhibin">Inhibin</a></li></ul></li> <li><i><a href="/wiki/HPG80" title="HPG80">hPG80</a></i></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Testicular_cancer" title="Testicular cancer">Testicular cancer</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Human_chorionic_gonadotropin" title="Human chorionic gonadotropin">βhCG</a></li> <li><a href="/wiki/Alpha-fetoprotein" title="Alpha-fetoprotein">Alpha-fetoprotein</a>/<a href="/wiki/AFP-L3" title="AFP-L3">AFP-L3</a></li> <li><a href="/wiki/CD30" title="CD30">CD30</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Prostate_cancer" title="Prostate cancer">Prostate cancer</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Prostate-specific_antigen" title="Prostate-specific antigen">Prostate-specific antigen</a></li> <li><a href="/wiki/Prostatic_acid_phosphatase" title="Prostatic acid phosphatase">Prostatic acid phosphatase</a></li> <li><a href="/wiki/Glutamate_carboxypeptidase_II" title="Glutamate carboxypeptidase II">Glutamate carboxypeptidase II</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">erbB-3 receptor</a></li> <li><a href="/wiki/Early_prostate_cancer_antigen-2" title="Early prostate cancer antigen-2">Early prostate cancer antigen-2</a></li> <li><a href="/wiki/SPINK1" title="SPINK1">SPINK1</a></li> <li><a href="/wiki/GOLM1" title="GOLM1">GOLM1</a></li> <li><a href="/wiki/PCA3" title="PCA3">PCA3</a></li> <li><a href="/wiki/TMPRSS2" title="TMPRSS2">TMPRSS2</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Germ_cell_tumor" title="Germ cell tumor">Germ cell tumor</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Homeobox_protein_NANOG" title="Homeobox protein NANOG">NANOG</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Bladder_cancer" title="Bladder cancer">Bladder cancer</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ERBB3" title="ERBB3">erbB-3 receptor</a></li> <li><a href="/wiki/NMP22" title="NMP22">NMP22</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Breast_cancer" title="Breast cancer">Breast cancer</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/CA_15-3" title="CA 15-3">CA 15-3</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">erbB-2 receptor</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">erbB-3 receptor</a></li> <li><a href="/wiki/Cathepsin_D" title="Cathepsin D">Cathepsin D</a></li> <li><a href="/wiki/CA_27-29" title="CA 27-29">CA 27-29</a></li> <li><a href="/wiki/HPG80" title="HPG80">hPG80</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">General histology</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Sarcoma" title="Sarcoma">Sarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Vimentin" title="Vimentin">Vimentin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Carcinoma" title="Carcinoma">Carcinoma</a> (<a href="/wiki/Epithelium" title="Epithelium">epithelium</a>)</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Cytokeratin" title="Cytokeratin">Cytokeratin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Musculoskeletal</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th id="Rhabdomyosarcoma20" scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Rhabdomyosarcoma" title="Rhabdomyosarcoma">Rhabdomyosarcoma</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Desmin" title="Desmin">Desmin</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Protein_kinases:_tyrosine_kinases_(EC_2.7.10)82" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Tyrosine_kinases" title="Template:Tyrosine kinases"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Tyrosine_kinases" title="Template talk:Tyrosine kinases"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Tyrosine_kinases" title="Special:EditPage/Template:Tyrosine kinases"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Protein_kinases:_tyrosine_kinases_(EC_2.7.10)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Protein_kinase" title="Protein kinase">Protein kinases</a>: <a href="/wiki/Tyrosine_kinase" title="Tyrosine kinase">tyrosine kinases</a> (<a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC</a> 2.7.10)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Receptor_tyrosine_kinases_(EC_2.7.10.1)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Receptor_tyrosine_kinase" title="Receptor tyrosine kinase">Receptor tyrosine kinases</a> (EC 2.7.10.1)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptors</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ErbB" title="ErbB">EGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGFR</a></li> <li><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ERBB2</a></li> <li><a href="/wiki/ERBB3" title="ERBB3">ERBB3</a></li> <li><a href="/wiki/ERBB4" title="ERBB4">ERBB4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Insulin_receptor" title="Insulin receptor">Insulin receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF1R</a></li> <li><a href="/wiki/Insulin_receptor" title="Insulin receptor">INSR</a></li> <li><a href="/wiki/INSRR" title="INSRR">INSRR</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RTK_class_III" title="RTK class III">PDGF receptor family</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Colony_stimulating_factor_1_receptor" title="Colony stimulating factor 1 receptor">CSF1R</a></li> <li><a href="/wiki/CD135" title="CD135">FLT3</a></li> <li><a href="/wiki/CD117" class="mw-redirect" title="CD117">KIT</a></li> <li><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGFR</a> (<a href="/wiki/PDGFRA" class="mw-redirect" title="PDGFRA">PDGFRA</a></li> <li><a href="/wiki/PDGFRB" title="PDGFRB">PDGFRB</a>)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></li> <li><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/VEGF_receptors" class="mw-redirect" title="VEGF receptors">VEGF receptors</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/FLT1" class="mw-redirect" title="FLT1">VEGFR1</a></li> <li><a href="/wiki/Kinase_insert_domain_receptor" title="Kinase insert domain receptor">VEGFR2</a></li> <li><a href="/wiki/VEGFR3" class="mw-redirect" title="VEGFR3">VEGFR3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">HGF receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-Met" class="mw-redirect" title="C-Met">MET</a></li> <li><a href="/wiki/MST1R" title="MST1R">RON</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">NTRK1</a></li> <li><a href="/wiki/NTRK2" class="mw-redirect" title="NTRK2">NTRK2</a></li> <li><a href="/wiki/NTRK3" class="mw-redirect" title="NTRK3">NTRK3</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Ephrin_receptor" title="Ephrin receptor">EPH receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/EPH_receptor_A1" title="EPH receptor A1">EPHA1</a></li> <li><a href="/wiki/EPH_receptor_A2" title="EPH receptor A2">EPHA2</a></li> <li><a href="/wiki/EPH_receptor_A3" title="EPH receptor A3">EPHA3</a></li> <li><a href="/wiki/EPH_receptor_A4" title="EPH receptor A4">EPHA4</a></li> <li><a href="/wiki/EPH_receptor_A5" title="EPH receptor A5">EPHA5</a></li> <li><a href="/wiki/EPHA6" title="EPHA6">EPHA6</a></li> <li><a href="/wiki/EPHA7" title="EPHA7">EPHA7</a></li> <li><a href="/wiki/EPHA8" title="EPHA8">EPHA8</a></li> <li><a href="/wiki/EPH_receptor_B1" title="EPH receptor B1">EPHB1</a></li> <li><a href="/wiki/EPH_receptor_B2" title="EPH receptor B2">EPHB2</a></li> <li><a href="/wiki/EPHB3" title="EPHB3">EPHB3</a></li> <li><a href="/wiki/EPH_receptor_B4" title="EPH receptor B4">EPHB4</a></li> <li><a href="/w/index.php?title=EPHB5&action=edit&redlink=1" class="new" title="EPHB5 (page does not exist)">EPHB5</a></li> <li><a href="/wiki/EPHB6" title="EPHB6">EPHB6</a></li> <li><a href="/w/index.php?title=EPHX&action=edit&redlink=1" class="new" title="EPHX (page does not exist)">EPHX</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Leukocyte_receptor_tyrosine_kinase" title="Leukocyte receptor tyrosine kinase">LTK</a></li> <li><a href="/wiki/Anaplastic_lymphoma_kinase" title="Anaplastic lymphoma kinase">ALK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">TIE receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TIE1" title="TIE1">TIE</a></li> <li><a href="/wiki/TEK_tyrosine_kinase" title="TEK tyrosine kinase">TEK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Receptor_tyrosine_kinase-like_orphan_receptor" title="Receptor tyrosine kinase-like orphan receptor">ROR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROR1" title="ROR1">ROR1</a></li> <li><a href="/wiki/ROR2" title="ROR2">ROR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/DDR1" title="DDR1">DDR receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/DDR1" title="DDR1">DDR1</a></li> <li><a href="/wiki/Discoidin_domain-containing_receptor_2" title="Discoidin domain-containing receptor 2">DDR2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK7" title="PTK7">PTK7 receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK7" title="PTK7">PTK7</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Related_to_receptor_tyrosine_kinase" title="Related to receptor tyrosine kinase">RYK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/MuSK_protein" title="MuSK protein">MuSK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/MuSK_protein" title="MuSK protein">MUSK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">ROS receptor family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/ROS1" title="ROS1">ROS1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AATK" title="AATK">AATYK receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AATK" title="AATK">AATYK</a></li> <li><a href="/wiki/LMTK2" title="LMTK2">AATYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/AXL_receptor_tyrosine_kinase" title="AXL receptor tyrosine kinase">AXL</a></li> <li><a href="/wiki/MERTK" title="MERTK">MER</a></li> <li><a href="/wiki/TYRO3" title="TYRO3">TYRO3</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET receptor</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">uncategorised</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/STYK1" title="STYK1">STYK1</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks mw-collapsible mw-collapsed navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><div id="Non-receptor_tyrosine_kinases_(EC_2.7.10.2)82" style="font-size:114%;margin:0 4em"><a href="/wiki/Non-receptor_tyrosine_kinase" title="Non-receptor tyrosine kinase">Non-receptor tyrosine kinases</a> (EC 2.7.10.2)</div></th></tr><tr><td colspan="2" class="navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/ABL_(gene)" title="ABL (gene)">ABL</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Abl_gene" class="mw-redirect" title="Abl gene">ABL1</a></li> <li><a href="/wiki/ABL2" title="ABL2">ARG</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TNK2" title="TNK2">ACK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TNK2" title="TNK2">ACK1</a></li> <li><a href="/w/index.php?title=TNK1&action=edit&redlink=1" class="new" title="TNK1 (page does not exist)">TNK1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_CSK" title="Tyrosine-protein kinase CSK">CSK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/C-src_tyrosine_kinase" class="mw-redirect" title="C-src tyrosine kinase">CSK</a></li> <li><a href="/wiki/Megakaryocyte-associated_tyrosine_kinase" title="Megakaryocyte-associated tyrosine kinase">MATK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/PTK2" title="PTK2">FAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/PTK2" title="PTK2">FAK</a></li> <li><a href="/wiki/PTK2B" title="PTK2B">PYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Feline_sarcoma_oncogene" class="mw-redirect" title="Feline sarcoma oncogene">FES</a></li> <li><a href="/wiki/FER_(gene)" title="FER (gene)">FER</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Fyn-related_kinase" title="Fyn-related kinase">FRK</a></li> <li><a href="/wiki/PTK6" title="PTK6">BRK</a></li> <li><a href="/w/index.php?title=SRMS_(gene)&action=edit&redlink=1" class="new" title="SRMS (gene) (page does not exist)">SRMS</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Janus_kinase" title="Janus kinase">JAK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Janus_kinase_1" title="Janus kinase 1">JAK1</a></li> <li><a href="/wiki/Janus_kinase_2" title="Janus kinase 2">JAK2</a></li> <li><a href="/wiki/Janus_kinase_3" title="Janus kinase 3">JAK3</a></li> <li><a href="/wiki/Tyrosine_kinase_2" title="Tyrosine kinase 2">TYK2</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-A family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Proto-oncogene_tyrosine-protein_kinase_Src" title="Proto-oncogene tyrosine-protein kinase Src">SRC</a></li> <li><a href="/wiki/FGR_(gene)" title="FGR (gene)">FGR</a></li> <li><a href="/wiki/FYN" title="FYN">FYN</a></li> <li><a href="/wiki/YES1" class="mw-redirect" title="YES1">YES1</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">SRC-B family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_BLK" title="Tyrosine-protein kinase BLK">BLK</a></li> <li><a href="/wiki/HCK" title="HCK">HCK</a></li> <li><a href="/wiki/Lck" class="mw-redirect" title="Lck">LCK</a></li> <li><a href="/wiki/LYN" title="LYN">LYN</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a> family</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/TEC_(gene)" title="TEC (gene)">TEC</a></li> <li><a href="/wiki/BMX_(gene)" title="BMX (gene)">BMX</a></li> <li><a href="/wiki/Bruton%27s_tyrosine_kinase" title="Bruton's tyrosine kinase">BTK</a></li> <li><a href="/wiki/ITK_(gene)" title="ITK (gene)">ITK</a></li> <li><a href="/wiki/TXK_(gene)" title="TXK (gene)">TXK</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%"><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a> family</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Tyrosine-protein_kinase_SYK" title="Tyrosine-protein kinase SYK">SYK</a></li> <li><a href="/wiki/ZAP-70" class="mw-redirect" title="ZAP-70">ZAP70</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr></tbody></table><div></div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Enzymes56" style="padding:3px"><table class="nowraplinks mw-collapsible autocollapse navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Enzymes" title="Template:Enzymes"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Enzymes" title="Template talk:Enzymes"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Enzymes" title="Special:EditPage/Template:Enzymes"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Enzymes56" style="font-size:114%;margin:0 4em"><a href="/wiki/Enzyme" title="Enzyme">Enzymes</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%">Activity</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Active_site" title="Active site">Active site</a></li> <li><a href="/wiki/Binding_site" title="Binding site">Binding site</a></li> <li><a href="/wiki/Catalytic_triad" title="Catalytic triad">Catalytic triad</a></li> <li><a href="/wiki/Oxyanion_hole" title="Oxyanion hole">Oxyanion hole</a></li> <li><a href="/wiki/Enzyme_promiscuity" title="Enzyme promiscuity">Enzyme promiscuity</a></li> <li><a href="/wiki/Diffusion-limited_enzyme" title="Diffusion-limited enzyme">Diffusion-limited enzyme</a></li> <li><a href="/wiki/Cofactor_(biochemistry)" title="Cofactor (biochemistry)">Cofactor</a></li> <li><a href="/wiki/Enzyme_catalysis" title="Enzyme catalysis">Enzyme catalysis</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Regulation</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Allosteric_regulation" title="Allosteric regulation">Allosteric regulation</a></li> <li><a href="/wiki/Cooperativity" title="Cooperativity">Cooperativity</a></li> <li><a href="/wiki/Enzyme_inhibitor" title="Enzyme inhibitor">Enzyme inhibitor</a></li> <li><a href="/wiki/Enzyme_activator" title="Enzyme activator">Enzyme activator</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Classification</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_Commission_number" title="Enzyme Commission number">EC number</a></li> <li><a href="/wiki/Protein_superfamily" title="Protein superfamily">Enzyme superfamily</a></li> <li><a href="/wiki/Protein_family" title="Protein family">Enzyme family</a></li> <li><a href="/wiki/List_of_enzymes" title="List of enzymes">List of enzymes</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Kinetics</th><td class="navbox-list-with-group navbox-list navbox-even hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><a href="/wiki/Enzyme_kinetics" title="Enzyme kinetics">Enzyme kinetics</a></li> <li><a href="/wiki/Eadie%E2%80%93Hofstee_diagram" title="Eadie–Hofstee diagram">Eadie–Hofstee diagram</a></li> <li><a href="/wiki/Hanes%E2%80%93Woolf_plot" title="Hanes–Woolf plot">Hanes–Woolf plot</a></li> <li><a href="/wiki/Lineweaver%E2%80%93Burk_plot" title="Lineweaver–Burk plot">Lineweaver–Burk plot</a></li> <li><a href="/wiki/Michaelis%E2%80%93Menten_kinetics" title="Michaelis–Menten kinetics">Michaelis–Menten kinetics</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%">Types</th><td class="navbox-list-with-group navbox-list navbox-odd hlist" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><b>EC1 <a href="/wiki/Oxidoreductase" title="Oxidoreductase">Oxidoreductases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_1)" title="List of EC numbers (EC 1)">list</a>)</li> <li><b>EC2 <a href="/wiki/Transferase" title="Transferase">Transferases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_2)" title="List of EC numbers (EC 2)">list</a>)</li> <li><b>EC3 <a href="/wiki/Hydrolase" title="Hydrolase">Hydrolases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_3)" title="List of EC numbers (EC 3)">list</a>)</li> <li><b>EC4 <a href="/wiki/Lyase" title="Lyase">Lyases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_4)" title="List of EC numbers (EC 4)">list</a>)</li> <li><b>EC5 <a href="/wiki/Isomerase" title="Isomerase">Isomerases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_5)" title="List of EC numbers (EC 5)">list</a>)</li> <li><b>EC6 <a href="/wiki/Ligase" title="Ligase">Ligases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_6)" title="List of EC numbers (EC 6)">list</a>)</li> <li><b>EC7 <a href="/wiki/Translocase" title="Translocase">Translocases</a></b> (<a href="/wiki/List_of_EC_numbers_(EC_7)" title="List of EC numbers (EC 7)">list</a>)</li></ul> </div></td></tr></tbody></table></div> <div class="navbox-styles"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1236075235" /></div><div role="navigation" class="navbox" aria-labelledby="Growth_factor_receptor_modulators607" style="padding:3px"><table class="nowraplinks hlist mw-collapsible mw-collapsed navbox-inner" style="border-spacing:0;background:transparent;color:inherit"><tbody><tr><th scope="col" class="navbox-title" colspan="2"><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1129693374" /><link rel="mw-deduplicated-inline-style" href="mw-data:TemplateStyles:r1239400231" /><div class="navbar plainlinks hlist navbar-mini"><ul><li class="nv-view"><a href="/wiki/Template:Growth_factor_receptor_modulators" title="Template:Growth factor receptor modulators"><abbr title="View this template">v</abbr></a></li><li class="nv-talk"><a href="/wiki/Template_talk:Growth_factor_receptor_modulators" title="Template talk:Growth factor receptor modulators"><abbr title="Discuss this template">t</abbr></a></li><li class="nv-edit"><a href="/wiki/Special:EditPage/Template:Growth_factor_receptor_modulators" title="Special:EditPage/Template:Growth factor receptor modulators"><abbr title="Edit this template">e</abbr></a></li></ul></div><div id="Growth_factor_receptor_modulators607" style="font-size:114%;margin:0 4em"><a href="/wiki/Growth_factor_receptor" title="Growth factor receptor">Growth factor receptor</a> <a href="/wiki/Receptor_modulator" title="Receptor modulator">modulators</a></div></th></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Angiopoietin_receptor" title="Angiopoietin receptor">Angiopoietin</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Angiopoietin_1" title="Angiopoietin 1">Angiopoietin 1</a></li> <li><a href="/wiki/Angiopoietin_4" class="mw-redirect" title="Angiopoietin 4">Angiopoietin 4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/Angiopoietin_2" class="mw-redirect" title="Angiopoietin 2">Angiopoietin 2</a></li> <li><a href="/w/index.php?title=Angiopoietin_3&action=edit&redlink=1" class="new" title="Angiopoietin 3 (page does not exist)">Angiopoietin 3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Evinacumab" title="Evinacumab">Evinacumab</a> (against angiopoietin 3)</li> <li><a href="/wiki/Nesvacumab" title="Nesvacumab">Nesvacumab</a> (against angiopoietin 2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Axokine" class="mw-redirect" title="Axokine">Axokine</a></li> <li><a href="/wiki/Ciliary_neurotrophic_factor_receptor" title="Ciliary neurotrophic factor receptor">CNTF</a></li> <li><a href="/w/index.php?title=Dapiclermin&action=edit&redlink=1" class="new" title="Dapiclermin (page does not exist)">Dapiclermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF (ErbB)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Epidermal_growth_factor_receptor" title="Epidermal growth factor receptor">EGF<br /><small>(ErbB1/HER1)</small></a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Amphiregulin" title="Amphiregulin">Amphiregulin</a></li> <li><a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epidermal_growth_factor" title="Epidermal growth factor">EGF (urogastrone)</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Epiregulin" title="Epiregulin">Epiregulin</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Murodermin" title="Murodermin">Murodermin</a></li> <li><a href="/wiki/Nepidermin" title="Nepidermin">Nepidermin</a></li> <li><a href="/wiki/Transforming_growth_factor_alpha" class="mw-redirect" title="Transforming growth factor alpha">Transforming growth factor alpha (TGFα)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Brigatinib" title="Brigatinib">Brigatinib</a></li> <li><a href="/wiki/Canertinib" title="Canertinib">Canertinib</a></li> <li><a href="/wiki/Dacomitinib" title="Dacomitinib">Dacomitinib</a></li> <li><a href="/wiki/Erlotinib" title="Erlotinib">Erlotinib</a></li> <li><a href="/wiki/Gefitinib" title="Gefitinib">Gefitinib</a></li> <li><a href="/wiki/Grandinin" title="Grandinin">Grandinin</a></li> <li><a href="/wiki/Icotinib" title="Icotinib">Icotinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Osimertinib" title="Osimertinib">Osimertinib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Cetuximab" title="Cetuximab">Cetuximab</a></li> <li><a href="/w/index.php?title=Depatuxizumab&action=edit&redlink=1" class="new" title="Depatuxizumab (page does not exist)">Depatuxizumab</a></li> <li><a href="/wiki/Depatuxizumab_mafodotin" title="Depatuxizumab mafodotin">Depatuxizumab mafodotin</a></li> <li><a href="/wiki/Futuximab" title="Futuximab">Futuximab</a></li> <li><a href="/wiki/Imgatuzumab" title="Imgatuzumab">Imgatuzumab</a></li> <li><a href="/wiki/Matuzumab" title="Matuzumab">Matuzumab</a></li> <li><a href="/wiki/Necitumumab" title="Necitumumab">Necitumumab</a></li> <li><a href="/wiki/Nimotuzumab" title="Nimotuzumab">Nimotuzumab</a></li> <li><a href="/wiki/Panitumumab" title="Panitumumab">Panitumumab</a></li> <li><a href="/wiki/Zalutumumab" title="Zalutumumab">Zalutumumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER2/neu" class="mw-redirect" title="HER2/neu">ErbB2/HER2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <i>Unknown/none</i></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Ertumaxomab" title="Ertumaxomab">Ertumaxomab</a></li> <li><a href="/wiki/Pertuzumab" title="Pertuzumab">Pertuzumab</a></li> <li><a href="/wiki/Trastuzumab" title="Trastuzumab">Trastuzumab</a></li> <li><a href="/wiki/Trastuzumab_deruxtecan" title="Trastuzumab deruxtecan">Trastuzumab deruxtecan</a></li> <li><a href="/w/index.php?title=Trastuzumab_duocarmazine&action=edit&redlink=1" class="new" title="Trastuzumab duocarmazine (page does not exist)">Trastuzumab duocarmazine</a></li> <li><a href="/wiki/Trastuzumab_emtansine" title="Trastuzumab emtansine">Trastuzumab emtansine</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Afatinib" title="Afatinib">Afatinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Mubritinib" title="Mubritinib">Mubritinib</a></li> <li><a href="/wiki/Neratinib" title="Neratinib">Neratinib</a></li> <li><a href="/wiki/Tucatinib" title="Tucatinib">Tucatinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER3" class="mw-redirect" title="HER3">ErbB3/HER3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/CSPG5" title="CSPG5">6 (neuroglycan C)</a>)</li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Duligotumab" class="mw-redirect" title="Duligotumab">Duligotumab</a></li> <li><a href="/wiki/Patritumab" title="Patritumab">Patritumab</a></li> <li><a href="/wiki/Seribantumab" title="Seribantumab">Seribantumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/HER4" class="mw-redirect" title="HER4">ErbB4/HER4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Betacellulin" title="Betacellulin">Betacellulin</a></li> <li><a href="/wiki/Epigen" title="Epigen">Epigen</a></li> <li><a href="/wiki/Heparin-binding_EGF-like_growth_factor" title="Heparin-binding EGF-like growth factor">Heparin-binding EGF-like growth factor (HB-EGF)</a></li> <li><a href="/wiki/Neuregulin" title="Neuregulin">Neuregulins (heregulins)</a> (<a href="/wiki/Neuregulin-1" class="mw-redirect" title="Neuregulin-1">1</a>, <a href="/wiki/NRG2" class="mw-redirect" title="NRG2">2</a>, <a href="/wiki/NRG3" class="mw-redirect" title="NRG3">3</a>, <a href="/wiki/NRG4" class="mw-redirect" title="NRG4">4</a>, <a href="/w/index.php?title=Tomoregulin&action=edit&redlink=1" class="new" title="Tomoregulin (page does not exist)">5 (tomoregulin, TMEFF)</a>)</li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor" title="Fibroblast growth factor receptor">FGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_1" title="Fibroblast growth factor receptor 1">FGFR1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF20" title="FGF20">20</a>)</li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li> <li><a href="/w/index.php?title=Velafermin&action=edit&redlink=1" class="new" title="Velafermin (page does not exist)">Velafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_2" title="Fibroblast growth factor receptor 2">FGFR2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF3" title="FGF3">3</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF5" title="FGF5">5</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF7" title="FGF7">7</a> (<a href="/wiki/Keratinocyte_growth_factor" title="Keratinocyte growth factor">KGF</a>), <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF10" title="FGF10">10 (KGF2)</a>, <a href="/wiki/FGF17" title="FGF17">17</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF22" title="FGF22">22</a>)</li> <li><a href="/wiki/Palifermin" title="Palifermin">Palifermin</a></li> <li><a href="/w/index.php?title=Repifermin&action=edit&redlink=1" class="new" title="Repifermin (page does not exist)">Repifermin</a></li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=Aprutumab&action=edit&redlink=1" class="new" title="Aprutumab (page does not exist)">Aprutumab</a></li> <li><a href="/w/index.php?title=Aprutumab_ixadotin&action=edit&redlink=1" class="new" title="Aprutumab ixadotin (page does not exist)">Aprutumab ixadotin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Infigratinib" title="Infigratinib">Infigratinib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_3" title="Fibroblast growth factor receptor 3">FGFR3</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF18" title="FGF18">18</a>, <a href="/wiki/FGF23" class="mw-redirect" title="FGF23">23</a>)</li> <li><a href="/wiki/Selpercatinib" title="Selpercatinib">Selpercatinib</a></li> <li><a href="/wiki/Sprifermin" title="Sprifermin">Sprifermin</a></li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Burosumab" title="Burosumab">Burosumab</a> (against FGF23)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Fibroblast_growth_factor_receptor_4" title="Fibroblast growth factor receptor 4">FGFR4</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=Ersofermin&action=edit&redlink=1" class="new" title="Ersofermin (page does not exist)">Ersofermin</a></li> <li><a href="/wiki/Fibroblast_growth_factor" title="Fibroblast growth factor">FGF</a> (<a href="/wiki/FGF1" class="mw-redirect" title="FGF1">1</a>, <a href="/wiki/FGF2" class="mw-redirect" title="FGF2">2 (bFGF)</a>, <a href="/wiki/FGF4" title="FGF4">4</a>, <a href="/wiki/FGF6" title="FGF6">6</a>, <a href="/wiki/FGF8" class="mw-redirect" title="FGF8">8</a>, <a href="/wiki/FGF9" title="FGF9">9</a>, <a href="/wiki/FGF19" title="FGF19">19</a>)</li> <li><a href="/wiki/Trafermin" title="Trafermin">Trafermin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/FGF15/19" title="FGF15/19">FGF15/19</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Hepatocyte_growth_factor_receptor" title="Hepatocyte growth factor receptor">HGF (c-Met)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Fosgonimeton" title="Fosgonimeton">Fosgonimeton</a></li> <li><a href="/wiki/Hepatocyte_growth_factor" title="Hepatocyte growth factor">Hepatocyte growth factor</a></li></ul> <ul><li><i>Potentiators:</i> <a href="/wiki/Dihexa" title="Dihexa">Dihexa (PNB-0408)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AM7_(drug)&action=edit&redlink=1" class="new" title="AM7 (drug) (page does not exist)">AM7</a></li> <li><a href="/w/index.php?title=AMG-458&action=edit&redlink=1" class="new" title="AMG-458 (page does not exist)">AMG-458</a></li> <li><a href="/w/index.php?title=Amuvatinib&action=edit&redlink=1" class="new" title="Amuvatinib (page does not exist)">Amuvatinib</a></li> <li><a href="/w/index.php?title=BMS-777607&action=edit&redlink=1" class="new" title="BMS-777607 (page does not exist)">BMS-777607</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Capmatinib" title="Capmatinib">Capmatinib</a></li> <li><a href="/wiki/Crizotinib" title="Crizotinib">Crizotinib</a></li> <li><a href="/wiki/Foretinib" title="Foretinib">Foretinib</a></li> <li><a href="/w/index.php?title=Golvatinib&action=edit&redlink=1" class="new" title="Golvatinib (page does not exist)">Golvatinib</a></li> <li><a href="/w/index.php?title=INCB28060&action=edit&redlink=1" class="new" title="INCB28060 (page does not exist)">INCB28060</a></li> <li><a href="/w/index.php?title=JNJ-38877605&action=edit&redlink=1" class="new" title="JNJ-38877605 (page does not exist)">JNJ-38877605</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/w/index.php?title=MK-2461&action=edit&redlink=1" class="new" title="MK-2461 (page does not exist)">MK-2461</a></li> <li><a href="/w/index.php?title=PF-04217903&action=edit&redlink=1" class="new" title="PF-04217903 (page does not exist)">PF-04217903</a></li> <li><a href="/w/index.php?title=PF-2341066&action=edit&redlink=1" class="new" title="PF-2341066 (page does not exist)">PF-2341066</a></li> <li><a href="/w/index.php?title=PHA-665752&action=edit&redlink=1" class="new" title="PHA-665752 (page does not exist)">PHA-665752</a></li> <li><a href="/w/index.php?title=SU-11274&action=edit&redlink=1" class="new" title="SU-11274 (page does not exist)">SU-11274</a></li> <li><a href="/wiki/Tivantinib" title="Tivantinib">Tivantinib</a></li> <li><a href="/wiki/Volitinib" class="mw-redirect" title="Volitinib">Volitinib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Emibetuzumab" title="Emibetuzumab">Emibetuzumab</a></li> <li><a href="/wiki/Ficlatuzumab" title="Ficlatuzumab">Ficlatuzumab</a></li> <li><a href="/wiki/Flanvotumab" title="Flanvotumab">Flanvotumab</a></li> <li><a href="/wiki/Onartuzumab" title="Onartuzumab">Onartuzumab</a></li> <li><a href="/wiki/Rilotumumab" title="Rilotumumab">Rilotumumab</a></li> <li><a href="/w/index.php?title=Telisotuzumab&action=edit&redlink=1" class="new" title="Telisotuzumab (page does not exist)">Telisotuzumab</a></li> <li><a href="/wiki/Telisotuzumab_vedotin" title="Telisotuzumab vedotin">Telisotuzumab vedotin</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Somatomedin_receptor" title="Somatomedin receptor">IGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_1_receptor" title="Insulin-like growth factor 1 receptor">IGF-1</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Des(1-3)IGF-1" title="Des(1-3)IGF-1">des(1-3)IGF-1</a></li> <li><a href="/wiki/Insulin-like_growth_factor_1" title="Insulin-like growth factor 1">Insulin-like growth factor-1 (somatomedin C)</a></li> <li><a href="/wiki/IGF-1_LR3" title="IGF-1 LR3">IGF-1 LR3</a></li> <li><a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li> <li><a href="/wiki/Insulin" title="Insulin">Insulin</a></li> <li><a href="/wiki/Mecasermin" title="Mecasermin">Mecasermin</a></li> <li><a href="/wiki/Mecasermin_rinfabate" title="Mecasermin rinfabate">Mecasermin rinfabate</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=BMS-754807&action=edit&redlink=1" class="new" title="BMS-754807 (page does not exist)">BMS-754807</a></li> <li><a href="/wiki/Linsitinib" title="Linsitinib">Linsitinib</a></li> <li><a href="/w/index.php?title=NVP-ADW742&action=edit&redlink=1" class="new" title="NVP-ADW742 (page does not exist)">NVP-ADW742</a></li> <li><a href="/w/index.php?title=NVP-AEW541&action=edit&redlink=1" class="new" title="NVP-AEW541 (page does not exist)">NVP-AEW541</a></li> <li><a href="/w/index.php?title=OSl-906&action=edit&redlink=1" class="new" title="OSl-906 (page does not exist)">OSl-906</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/w/index.php?title=AVE-1642&action=edit&redlink=1" class="new" title="AVE-1642 (page does not exist)">AVE-1642</a></li> <li><a href="/wiki/Cixutumumab" title="Cixutumumab">Cixutumumab</a></li> <li><a href="/wiki/Dalotuzumab" title="Dalotuzumab">Dalotuzumab</a></li> <li><a href="/wiki/Figitumumab" title="Figitumumab">Figitumumab</a></li> <li><a href="/wiki/Ganitumab" title="Ganitumab">Ganitumab</a></li> <li><a href="/wiki/Robatumumab" title="Robatumumab">Robatumumab</a></li> <li><a href="/w/index.php?title=R1507&action=edit&redlink=1" class="new" title="R1507 (page does not exist)">R1507</a></li> <li><a href="/wiki/Teprotumumab" title="Teprotumumab">Teprotumumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Insulin-like_growth_factor_2_receptor" title="Insulin-like growth factor 2 receptor">IGF-2</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists</i>: <a href="/wiki/Insulin-like_growth_factor_2" title="Insulin-like growth factor 2">Insulin-like growth factor-2 (somatomedin A)</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Dusigitumab" title="Dusigitumab">Dusigitumab</a></li> <li><a href="/w/index.php?title=Xentuzumab&action=edit&redlink=1" class="new" title="Xentuzumab (page does not exist)">Xentuzumab</a> (against IGF-1 and IGF-2)</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Binding proteins:</i> <a href="/wiki/Insulin-like_growth_factor-binding_protein" title="Insulin-like growth factor-binding protein">IGFBP</a> (<a href="/wiki/IGFBP1" title="IGFBP1">1</a>, <a href="/wiki/IGFBP2" title="IGFBP2">2</a>, <a href="/wiki/IGFBP3" title="IGFBP3">3</a>, <a href="/wiki/IGFBP4" title="IGFBP4">4</a>, <a href="/wiki/IGFBP5" title="IGFBP5">5</a>, <a href="/wiki/IGFBP6" title="IGFBP6">6</a>, <a href="/wiki/IGFBP7" title="IGFBP7">7</a>)</li></ul> <ul><li><i>Cleavage products/derivatives with unknown target:</i> <a href="/w/index.php?title=Glypromate&action=edit&redlink=1" class="new" title="Glypromate (page does not exist)">Glypromate (GPE, (1-3)IGF-1)</a></li> <li><a href="/wiki/Trofinetide" title="Trofinetide">Trofinetide</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Low-affinity_nerve_growth_factor_receptor" title="Low-affinity nerve growth factor receptor">LNGF (p75<sup>NTR</sup>)</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/w/index.php?title=EVT-901&action=edit&redlink=1" class="new" title="EVT-901 (page does not exist)">EVT-901 (SAR-127963)</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Antibodies:</i> <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=LEVI-04&action=edit&redlink=1" class="new" title="LEVI-04 (page does not exist)">LEVI-04 (p75<sup>NTR</sup>-Fc)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Platelet-derived_growth_factor_receptor" title="Platelet-derived growth factor receptor">PDGF</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Becaplermin" title="Becaplermin">Becaplermin</a></li> <li><a href="/wiki/Platelet-derived_growth_factor" title="Platelet-derived growth factor">Platelet-derived growth factor</a> (<a href="/wiki/PDGFA" title="PDGFA">A</a>, <a href="/wiki/PDGFB" title="PDGFB">B</a>, <a href="/wiki/PDGFC" title="PDGFC">C</a>, <a href="/wiki/PDGFD" title="PDGFD">D</a>)</li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Avapritinib" title="Avapritinib">Avapritinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Crenolanib" title="Crenolanib">Crenolanib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Radotinib" title="Radotinib">Radotinib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Olaratumab" title="Olaratumab">Olaratumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Tovetumab" title="Tovetumab">Tovetumab</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/RET_proto-oncogene" title="RET proto-oncogene">RET (GFL)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B11" class="mw-redirect" title="GFRα1">GFRα1</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Glial_cell_line-derived_neurotrophic_factor" title="Glial cell line-derived neurotrophic factor">Glial cell line-derived neurotrophic factor (GDNF)</a></li> <li><a href="/w/index.php?title=Liatermin&action=edit&redlink=1" class="new" title="Liatermin (page does not exist)">Liatermin</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B12" class="mw-redirect" title="GFRα2">GFRα2</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Neurturin" title="Neurturin">Neurturin (NRTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B13" class="mw-redirect" title="GFRα3">GFRα3</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Artemin" title="Artemin">Artemin (ARTN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/GFR%CE%B14" class="mw-redirect" title="GFRα4">GFRα4</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Persephin" title="Persephin">Persephin (PSPN)</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Unsorted</th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/CD117" class="mw-redirect" title="CD117">SCF (c-Kit)</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Ancestim" title="Ancestim">Ancestim</a></li> <li><a href="/wiki/Stem_cell_factor" title="Stem cell factor">Stem cell factor</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Dasatinib" title="Dasatinib">Dasatinib</a></li> <li><a href="/wiki/Imatinib" title="Imatinib">Imatinib</a></li> <li><a href="/wiki/Masitinib" title="Masitinib">Masitinib</a></li> <li><a href="/wiki/Nilotinib" title="Nilotinib">Nilotinib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Quizartinib" title="Quizartinib">Quizartinib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Transforming_growth_factor_beta_receptor" class="mw-redirect" title="Transforming growth factor beta receptor">TGFβ</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li>See <a href="/wiki/Template:TGF%CE%B2_receptor_superfamily_modulators" title="Template:TGFβ receptor superfamily modulators">here</a> instead.</li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Trk_receptor" title="Trk receptor">Trk</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"></div><table class="nowraplinks navbox-subgroup" style="border-spacing:0"><tbody><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkA_receptor" class="mw-redirect" title="TrkA receptor">TrkA</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/BNN-27" title="BNN-27">BNN-27</a></li> <li><a href="/wiki/Cenegermin" title="Cenegermin">Cenegermin</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Dehydroepiandrosterone_sulfate" title="Dehydroepiandrosterone sulfate">DHEA-S</a></li> <li><a href="/w/index.php?title=Gambogic_amide&action=edit&redlink=1" class="new" title="Gambogic amide (page does not exist)">Gambogic amide</a></li> <li><a href="/wiki/Nerve_growth_factor" title="Nerve growth factor">NGF</a></li> <li><a href="/wiki/Tavilermide" title="Tavilermide">Tavilermide</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/w/index.php?title=ALE-0540&action=edit&redlink=1" class="new" title="ALE-0540 (page does not exist)">ALE-0540</a></li> <li><a href="/wiki/Dexamethasone" title="Dexamethasone">Dexamethasone</a></li> <li><a href="/wiki/FX007" class="mw-redirect" title="FX007">FX007</a></li> <li><a href="/wiki/Testosterone" title="Testosterone">Testosterone</a></li></ul> <ul><li><i>Negative allosteric modulators:</i> <a href="/w/index.php?title=VM-902A&action=edit&redlink=1" class="new" title="VM-902A (page does not exist)">VM-902A</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=Milciclib&action=edit&redlink=1" class="new" title="Milciclib (page does not exist)">Milciclib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/w/index.php?title=SNA-120&action=edit&redlink=1" class="new" title="SNA-120 (page does not exist)">SNA-120 (pegylated K252a)</a>)</li></ul> <ul><li><i>Antibodies:</i> <i>Against TrkA:</i> <a href="/w/index.php?title=GBR-900&action=edit&redlink=1" class="new" title="GBR-900 (page does not exist)">GBR-900</a>; <i>Against NGF:</i> <a href="/w/index.php?title=ABT-110&action=edit&redlink=1" class="new" title="ABT-110 (page does not exist)">ABT-110 (PG110)</a></li> <li><a href="/w/index.php?title=ASP-6294&action=edit&redlink=1" class="new" title="ASP-6294 (page does not exist)">ASP-6294</a></li> <li><a href="/wiki/Fasinumab" title="Fasinumab">Fasinumab</a></li> <li><a href="/wiki/Frunevetmab" title="Frunevetmab">Frunevetmab</a></li> <li><a href="/wiki/Fulranumab" title="Fulranumab">Fulranumab</a></li> <li><a href="/w/index.php?title=MEDI-578&action=edit&redlink=1" class="new" title="MEDI-578 (page does not exist)">MEDI-578</a></li> <li><a href="/w/index.php?title=Ranevetmab&action=edit&redlink=1" class="new" title="Ranevetmab (page does not exist)">Ranevetmab</a></li> <li><a href="/wiki/Tanezumab" title="Tanezumab">Tanezumab</a></li></ul> <ul><li><i>Aptamers:</i> <i>Against NGF:</i> <a href="/w/index.php?title=RBM-004&action=edit&redlink=1" class="new" title="RBM-004 (page does not exist)">RBM-004</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/w/index.php?title=ReN-1820&action=edit&redlink=1" class="new" title="ReN-1820 (page does not exist)">ReN-1820 (TrkAd5)</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkB_receptor" class="mw-redirect" title="TrkB receptor">TrkB</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/w/index.php?title=3,7-Dihydroxyflavone&action=edit&redlink=1" class="new" title="3,7-Dihydroxyflavone (page does not exist)">3,7-DHF</a></li> <li><a href="/w/index.php?title=3,7,8,2%27-Tetrahydroxyflavone&action=edit&redlink=1" class="new" title="3,7,8,2'-Tetrahydroxyflavone (page does not exist)">3,7,8,2'-THF</a></li> <li><a href="/wiki/4%27-Dimethylamino-7,8-dihydroxyflavone" class="mw-redirect" title="4'-Dimethylamino-7,8-dihydroxyflavone">4'-DMA-7,8-DHF</a></li> <li><a href="/w/index.php?title=7,3%E2%80%B2-Dihydroxyflavone&action=edit&redlink=1" class="new" title="7,3′-Dihydroxyflavone (page does not exist)">7,3'-DHF</a></li> <li><a href="/wiki/7,8-Dihydroxyflavone" class="mw-redirect" title="7,8-Dihydroxyflavone">7,8-DHF</a></li> <li><a href="/w/index.php?title=7,8,2%27-Trihydroxyflavone&action=edit&redlink=1" class="new" title="7,8,2'-Trihydroxyflavone (page does not exist)">7,8,2'-THF</a></li> <li><a href="/wiki/7,8,3%27-Trihydroxyflavone" title="7,8,3'-Trihydroxyflavone">7,8,3'-THF</a></li> <li><a href="/wiki/Amitriptyline" title="Amitriptyline">Amitriptyline</a></li> <li><a href="/wiki/Brain-derived_neurotrophic_factor" title="Brain-derived neurotrophic factor">BDNF</a></li> <li><a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Deoxygedunin" title="Deoxygedunin">Deoxygedunin</a></li> <li><a href="/wiki/Deprenyl" title="Deprenyl">Deprenyl</a></li> <li><a href="/wiki/Diosmetin" title="Diosmetin">Diosmetin</a></li> <li><a href="/w/index.php?title=DMAQ-B1&action=edit&redlink=1" class="new" title="DMAQ-B1 (page does not exist)">DMAQ-B1</a></li> <li><a href="/wiki/HIOC" title="HIOC">HIOC</a></li> <li><a href="/wiki/LM22A-4" title="LM22A-4">LM22A-4</a></li> <li><a href="/wiki/N-Acetylserotonin" title="N-Acetylserotonin">N-Acetylserotonin</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li> <li><a href="/wiki/Neurotrophin-4" title="Neurotrophin-4">NT-4</a></li> <li><a href="/wiki/Norwogonin" title="Norwogonin">Norwogonin (5,7,8-THF)</a></li> <li><a href="/wiki/R7_(drug)" title="R7 (drug)">R7</a></li> <li><a href="/wiki/R13_(drug)" title="R13 (drug)">R13</a></li> <li><a href="/w/index.php?title=TDP6&action=edit&redlink=1" class="new" title="TDP6 (page does not exist)">TDP6</a></li></ul> <ul><li><i>Antagonists:</i> <a href="/wiki/ANA-12" title="ANA-12">ANA-12</a></li> <li><a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li> <li><a href="/wiki/Gossypetin" title="Gossypetin">Gossypetin (3,5,7,8,3',4'-HHF)</a></li></ul> <ul><li><i>Ligands:</i> <a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/TrkC_receptor" class="mw-redirect" title="TrkC receptor">TrkC</a></th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/BNN-20" title="BNN-20">BNN-20</a></li> <li><a href="/wiki/Dehydroepiandrosterone" title="Dehydroepiandrosterone">DHEA</a></li> <li><a href="/wiki/Neurotrophin-3" title="Neurotrophin-3">NT-3</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/w/index.php?title=AZD-6918&action=edit&redlink=1" class="new" title="AZD-6918 (page does not exist)">AZD-6918</a></li> <li><a href="/w/index.php?title=CE-245677&action=edit&redlink=1" class="new" title="CE-245677 (page does not exist)">CE-245677</a></li> <li><a href="/w/index.php?title=CH-7057288&action=edit&redlink=1" class="new" title="CH-7057288 (page does not exist)">CH-7057288</a></li> <li><a href="/w/index.php?title=DS-6051&action=edit&redlink=1" class="new" title="DS-6051 (page does not exist)">DS-6051</a></li> <li><a href="/wiki/Entrectinib" title="Entrectinib">Entrectinib</a></li> <li><a href="/w/index.php?title=GZ-389988&action=edit&redlink=1" class="new" title="GZ-389988 (page does not exist)">GZ-389988</a></li> <li><a href="/wiki/K252a" title="K252a">K252a</a></li> <li><a href="/wiki/Larotrectinib" title="Larotrectinib">Larotrectinib</a></li> <li><a href="/wiki/Lestaurtinib" title="Lestaurtinib">Lestaurtinib</a></li> <li><a href="/w/index.php?title=ONO-4474&action=edit&redlink=1" class="new" title="ONO-4474 (page does not exist)">ONO-4474</a></li> <li><a href="/w/index.php?title=ONO-5390556&action=edit&redlink=1" class="new" title="ONO-5390556 (page does not exist)">ONO-5390556</a></li> <li><a href="/w/index.php?title=PLX-7486&action=edit&redlink=1" class="new" title="PLX-7486 (page does not exist)">PLX-7486</a></li></ul> </div></td></tr></tbody></table><div></div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;"><a href="/wiki/Vascular_endothelial_growth_factor_receptor" class="mw-redirect" title="Vascular endothelial growth factor receptor">VEGF</a></th><td class="navbox-list-with-group navbox-list navbox-even" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Agonists:</i> <a href="/wiki/Placental_growth_factor" title="Placental growth factor">Placental growth factor (PGF)</a></li> <li><a href="/wiki/Ripretinib" title="Ripretinib">Ripretinib</a></li> <li><a href="/w/index.php?title=Telbermin&action=edit&redlink=1" class="new" title="Telbermin (page does not exist)">Telbermin</a></li> <li><a href="/wiki/Vascular_endothelial_growth_factor" title="Vascular endothelial growth factor">VEGF</a> (<a href="/wiki/Vascular_endothelial_growth_factor_A" title="Vascular endothelial growth factor A">A</a>, <a href="/wiki/Vascular_endothelial_growth_factor_B" title="Vascular endothelial growth factor B">B</a>, <a href="/wiki/Vascular_endothelial_growth_factor_C" title="Vascular endothelial growth factor C">C</a>, <a href="/wiki/Vascular_endothelial_growth_factor_D" class="mw-redirect" title="Vascular endothelial growth factor D">D (FIGF)</a>)</li></ul> <ul><li><i>Allosteric modulators:</i> <a href="/wiki/Cyclotraxin_B" title="Cyclotraxin B">Cyclotraxin B</a></li></ul> <ul><li><i>Kinase inhibitors:</i> <a href="/w/index.php?title=Agerafenib&action=edit&redlink=1" class="new" title="Agerafenib (page does not exist)">Agerafenib</a></li> <li><a href="/w/index.php?title=Altiratinib&action=edit&redlink=1" class="new" title="Altiratinib (page does not exist)">Altiratinib</a></li> <li><a href="/wiki/Axitinib" title="Axitinib">Axitinib</a></li> <li><a href="/wiki/Cabozantinib" title="Cabozantinib">Cabozantinib</a></li> <li><a href="/wiki/Cediranib" title="Cediranib">Cediranib</a></li> <li><a href="/wiki/Fruquintinib" title="Fruquintinib">Fruquintinib</a></li> <li><a href="/wiki/Lapatinib" title="Lapatinib">Lapatinib</a></li> <li><a href="/wiki/Lenvatinib" title="Lenvatinib">Lenvatinib</a></li> <li><a href="/wiki/Motesanib" title="Motesanib">Motesanib</a></li> <li><a href="/wiki/Nintedanib" title="Nintedanib">Nintedanib</a></li> <li><a href="/wiki/Pazopanib" title="Pazopanib">Pazopanib</a></li> <li><a href="/wiki/Pegaptanib" title="Pegaptanib">Pegaptanib</a></li> <li><a href="/wiki/Rebastinib" class="mw-redirect" title="Rebastinib">Rebastinib</a></li> <li><a href="/wiki/Regorafenib" title="Regorafenib">Regorafenib</a></li> <li><a href="/wiki/Semaxanib" title="Semaxanib">Semaxanib</a></li> <li><a href="/wiki/Sorafenib" title="Sorafenib">Sorafenib</a></li> <li><a href="/wiki/Sunitinib" title="Sunitinib">Sunitinib</a></li> <li><a href="/wiki/Toceranib" title="Toceranib">Toceranib</a></li> <li><a href="/wiki/Tivozanib" title="Tivozanib">Tivozanib</a></li> <li><a href="/wiki/Vandetanib" title="Vandetanib">Vandetanib</a></li> <li><a href="/w/index.php?title=WHI-P_154&action=edit&redlink=1" class="new" title="WHI-P 154 (page does not exist)">WHI-P 154</a></li></ul> <ul><li><i>Antibodies:</i> <a href="/wiki/Alacizumab_pegol" title="Alacizumab pegol">Alacizumab pegol</a></li> <li><a href="/wiki/Bevacizumab" title="Bevacizumab">Bevacizumab</a></li> <li><a href="/wiki/Icrucumab" title="Icrucumab">Icrucumab</a></li> <li><a href="/wiki/Ramucirumab" title="Ramucirumab">Ramucirumab</a></li> <li><a href="/wiki/Ranibizumab" title="Ranibizumab">Ranibizumab</a></li></ul> <ul><li><i>Decoy receptors:</i> <a href="/wiki/Aflibercept" title="Aflibercept">Aflibercept</a></li></ul> </div></td></tr><tr><th scope="row" class="navbox-group" style="width:1%;text-align:center;">Others</th><td class="navbox-list-with-group navbox-list navbox-odd" style="width:100%;padding:0"><div style="padding:0 0.25em"> <ul><li><i>Additional growth factors:</i> <a href="/wiki/Adrenomedullin" title="Adrenomedullin">Adrenomedullin</a></li> <li><a href="/wiki/Colony-stimulating_factor" title="Colony-stimulating factor">Colony-stimulating factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Connective_tissue_growth_factor" class="mw-redirect" title="Connective tissue growth factor">Connective tissue growth factor (CTGF)</a></li> <li><a href="/wiki/Ephrin" title="Ephrin">Ephrins</a> (<a href="/wiki/EFNA1" class="mw-redirect" title="EFNA1">A1</a>, <a href="/wiki/EFNA2" class="mw-redirect" title="EFNA2">A2</a>, <a href="/wiki/EFNA3" class="mw-redirect" title="EFNA3">A3</a>, <a href="/wiki/EFNA4" class="mw-redirect" title="EFNA4">A4</a>, <a href="/wiki/EFNA5" class="mw-redirect" title="EFNA5">A5</a>, <a href="/wiki/EFNB1" class="mw-redirect" title="EFNB1">B1</a>, <a href="/wiki/EFNB2" class="mw-redirect" title="EFNB2">B2</a>, <a href="/wiki/EFNB3" class="mw-redirect" title="EFNB3">B3</a>)</li> <li><a href="/wiki/Erythropoietin" title="Erythropoietin">Erythropoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Glucose-6-phosphate_isomerase" title="Glucose-6-phosphate isomerase">Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)</a></li> <li><a href="/wiki/Glia_maturation_factor" title="Glia maturation factor">Glia maturation factor (GMF)</a></li> <li><a href="/wiki/Hepatoma-derived_growth_factor" title="Hepatoma-derived growth factor">Hepatoma-derived growth factor (HDGF)</a></li> <li><a href="/wiki/Interleukin" title="Interleukin">Interleukins</a>/<a href="/wiki/T-cell_growth_factor" title="T-cell growth factor">T-cell growth factors</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Leukemia_inhibitory_factor" title="Leukemia inhibitory factor">Leukemia inhibitory factor (LIF)</a></li> <li><a href="/wiki/Macrophage-stimulating_protein" class="mw-redirect" title="Macrophage-stimulating protein">Macrophage-stimulating protein (MSP; HLP, HGFLP)</a></li> <li><a href="/wiki/Midkine" title="Midkine">Midkine (NEGF2)</a></li> <li><a href="/wiki/Migration-stimulating_factor" class="mw-redirect" title="Migration-stimulating factor">Migration-stimulating factor (MSF; PRG4)</a></li> <li><a href="/wiki/Oncomodulin" title="Oncomodulin">Oncomodulin</a></li> <li><a href="/wiki/Pituitary_adenylate_cyclase-activating_peptide" title="Pituitary adenylate cyclase-activating peptide">Pituitary adenylate cyclase-activating peptide (PACAP)</a></li> <li><a href="/wiki/Pleiotrophin" title="Pleiotrophin">Pleiotrophin</a></li> <li><a href="/wiki/Renalase" title="Renalase">Renalase</a></li> <li><a href="/wiki/Thrombopoietin" title="Thrombopoietin">Thrombopoietin</a> (see <a href="/wiki/Template:Cytokine_receptor_modulators" title="Template:Cytokine receptor modulators">here</a> instead)</li> <li><a href="/wiki/Wnt_signaling_pathway" title="Wnt signaling pathway">Wnt signaling proteins</a></li></ul> <ul><li><i>Additional growth factor receptor modulators:</i> <a href="/wiki/Cerebrolysin" title="Cerebrolysin">Cerebrolysin</a> (neurotrophin mixture)</li></ul> </div></td></tr></tbody></table></div> <style data-mw-deduplicate="TemplateStyles:r1130092004">.mw-parser-output .portal-bar{font-size:88%;font-weight:bold;display:flex;justify-content:center;align-items:baseline}.mw-parser-output .portal-bar-bordered{padding:0 2em;background-color:#fdfdfd;border:1px solid #a2a9b1;clear:both;margin:1em auto 0}.mw-parser-output .portal-bar-related{font-size:100%;justify-content:flex-start}.mw-parser-output .portal-bar-unbordered{padding:0 1.7em;margin-left:0}.mw-parser-output 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